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1. Dysfunction of proprioceptive sensory synapses is a pathogenic event and therapeutic target in mice and humans with spinal muscular atrophy

Author: Simon, CM, primary, Delestree, N, additional, Montes, J, additional, Gerstner, F, additional, Carranza, E, additional, Sowoidnich, L, additional, Buettner, JM, additional, Pagiazitis, JG, additional, Prat-Ortega, G, additional, Ensel, S, additional, Donadio, S, additional, Garcia, JL, additional, Kratimenos, P, additional, Chung, WK, additional, Sumner, CJ, additional, Weimer, LH, additional, Pirondini, E, additional, Capogrosso, M, additional, Pellizzoni, L, additional, Vivo, DC De, additional, and Mentis, GZ, additional
Published: 2024
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2. Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Author: Ronen, Sabrina, Costello, Joseph, Viswanath, P, Najac, C, Izquierdo-Garcia, JL, Pankov, A, Hong, C, Eriksson, P, Costello, JF, Pieper, RO, and Ronen, SM
Published: 2016

3. Metabolic reprogramming in mutant IDH1 glioma cells

Author: Pieper, Russell, Phillips, Joanna, Ronen, Sabrina, Izquierdo-Garcia, JL, Viswanath, P, Eriksson, P, Chaumeil, MM, Pieper, RO, Phillips, JJ, and Ronen, SM
Abstract: © 2015 Izquierdo-Garcia et al.Background: Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-keto
Published: 2015

4. Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase

Author: Ronen, Sabrina, Pieper, Russell, Phillips, Joanna, Izquierdo-Garcia, JL, Cai, LM, Chaumeil, MM, Eriksson, P, Robinson, AE, Pieper, RO, Phillips, JJ, and Ronen, SM
Abstract: Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leading to t
Published: 2014

5. HDAC Inhibition Induces Increased Choline Uptake and Elevated Phosphocholine Levels in MCF7 Breast Cancer Cells

Author: Ronen, Sabrina, Ward, CS, Eriksson, P, Izquierdo-Garcia, JL, Brandes, AH, and Ronen, SM
Abstract: Histone deacetylase (HDAC) inhibitors have emerged as effective antineoplastic agents in the clinic. Studies from our lab and others have reported that magnetic resonance spectroscopy (MRS)-detectable phosphocholine (PC) is elevated following SAHA treatmen
Published: 2013

6. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author: Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, Nyaywa, M, Alia, DB, Tandili, A, Paiva, L, Wime, AD, Chantada, GL, Fandino, AC, Sgroi, M, Papyan, R, Tamamyan, G, Camuglia, JE, Gole, GA, Clark, A, Lam, GC, Elder, JE, McKenzie, JD, Staffieri, SE, Jones, MM, Manudhane, R, Sia, D, Ritter-Sovinz, P, Schwab, C, Balayeva, R, Khan, Z, Nuruddin, M, Roy, SR, Rashid, R, Sultana, S, Shakoor, SA, Naumenko, L, Zhilyaeva, K, Bartoszek, P, Brichard, BG, De Potter, P, Bio, AIA, Salas, B, Coleoni Suarez, ME, Mbumba, FB, Bonanomi, MTBC, Donato Macedo, CR, Grigorovski, NDAK, Mattosinho, CCDS, Teixeira, LF, Oscar, AH, Veleva-Krasteva, NV, Bouda, GC, Kabore, RL, Philbert, R, Evina, TGA, Nkumbe, HE, Kamsang, P, Muyen, OM, Dimaras, H, Mallipatna, A, Hamel, P, Superstein, R, Paton, KE, Strahlendorf, C, Palet, JEKK, Tyau-Tyau, H, Cavieres, I, Lopez, JP, Oporto, J, Ossandon, D, Chen, W, Xiang, D, Du, Y, Li, K, Ji, X, Tang, J, Li, C, Xu, B, Qian, J, Xue, K, Sun, X, Wang, Y-Z, Zhang, Y, Wu, S-Q, Xiao, Y, Yang, H, Ye, H, Polania, RA, Berete, RC, Couitchere, L, Peric, S, Alemany-Rubio, E, Gonzalez-Rodriguez, L, Autrata, R, Kepak, T, Pochop, P, Svojgr, K, Gregersen, PA, Urbak, SF, Montero, MM, Budiongo, A, Yanga, JM, Amani, TBK, Lukamba, RM, Numbi, MN, Calle Jara, DA, Villacis Chafla, EG, Sanchez, GL, Abouelnaga, S, Afifi, MA, Elhaddad, AM, Ali, AM, Elzembely, M, Said, AMA, Ziko, OAO, Fuentes-Alabi, SL, Goenz, MA, Eerme, K, Klett, A, Hordofa, DF, Mengesha, AA, Sherief, ST, Kivela, TT, Nummi, K, Cassoux, N, Desjardins, L, Obono-Obiang, G, Kardava, T, Khotenashvili, Z, Bechrakis, NE, Biewald, EM, Schlueter, S, Ketteler, P, Amankwaa-Frempong, D, Essuman, VA, Paintsil, V, Renner, LA, Alejos, A, Giron, A, Carreras, YA, Fu, LD, Maldonado, C, Wong, ES, Yam, JC, Csoka, M, Maka, E, Aggarwal, P, Gupta, V, Bhaduri, A, Bhattacharyya, A, Das, A, Chawla, B, Das, P, Das, S, Gupta, H, Gupta, S, Verma, N, Kaliki, S, Khetan, V, Maitra, P, Mahajan, A, Menon, V, Mishra, DKC, Palanivelu, MS, Ramanjulu, R, Mudaliar, SS, Nair, AG, Natarajan, S, Seth, R, Singh, U, Bhat, S, Dudeja, G, Tripathy, D, Akib, IMNR, Pagarra, H, Amiruddin, PO, Kuntorini, MW, Armytasari, I, Supriyadi, E, Sutyawan, IWE, Yuliawati, P, Lutfi, D, Soebagjo, HD, Rahman, A, Sitorus, RS, Victor, AA, Tehuteru, ES, Widiarti, W, Nency, YM, Faranoush, M, Mehrvar, A, Tashvighi, M, Sedaghat, A, Ghassemi, F, Khodabande, A, Abdulqader, RA, Al-Shaheen, AASM, Al Ani, MH, Haydar, H, Al-Badri, SAF, Al-Jadiry, MF, Sabhan, AH, Al-Jumaily, U, Al-Mafrachi, AARM, Al-Shammary, EH, Al-Janabi, ANH, Qadir, AO, Capra, M, Blum, S, Gomel, N, Fabian, ID, Goldberg, H, Kapelushnik, N, Madgar, S, Vishnevskia-Dai, V, Frenkel, S, Pe'er, J, Gorfine, M, Refaeli, D, Steinberg, DM, Lavy, Y, Toledano, H, Caspi, S, De Francesco, S, Hadjistilianou, T, Ida, R, Valente, P, Midena, E, Parrozzani, R, Cowan-Lyn, KE, Vaughan, LO, Suzuki, S, Mohammad, MT, Yousef, YA, Manzhuova, L, Atsiaya, R, Matende, IO, Begimkulova, AS, Makimbetov, EK, Keomisy, J, Sayalith, P, Valeina, S, Viksnins, M, Al-Haddad, CE, Saab, RH, Alsawidi, KM, Elbahi, AM, Krivaitiene, D, Tateshi, B, Randrianarisoa, HL, Raobela, L, Msukwa, G, Nyirenda, C, Hamzah, N, Teh, KH, Sylla, F, Traore, F, Cheikh, SS, Zein, E, Perez, GG, Sanchez Orozco, AJ, Ortega-Hernandez, M, Ramirez-Ortiz, MA, Chuluunbat, T, Abdallah, E, Benmiloud, S, El Kettani, A, Hessissen, L, Almeida, AA, Limbu, B, Rajkarnikar, P, Saiju, R, Moll, AC, Wijsard, MVH, Cockcroft, RL, Ng, Y, Dodgshun, AJ, Calderon-Sotelo, P, Abdullahi, SU, Hassan, S, Umar, AB, Abdulrahaman, AA, Wali, AH, Ademola-Popoola, DS, Adio, A, Aghaji, AE, Ezegwui, IR, Akinsete, A, Musa, KO, Fasina, O, Ibanga, A, Nkanga, ED, Mustapha, T, Ribadu, D, Hummelen, M, Ahmad, A, Mushtaq, A, Qayyum, S, Chaudhry, S, Fadoo, Z, Jeeva, I, Masud, S, Hamid, SA, Zia, N, Siddiqui, SN, Janjua, T, Yaqub, MA, Khaqan, HA, Quintero D, K, Yee, R, Jairaj, V, Cano, MR, Fernandez, DDPG, Diaz Coronado, RY, Zapata Lopez, AM, Garcia, JL, Ponce, J, Garcia Pacheco, HN, Pascual Morales, CR, Vasquez Anchaya, JK, Tarrillo Leiva, FF, Alcasabas, APA, Mercado, GJ, Cieslik, K, Hautz, W, Rogowska, A, Castela, G, Silva, S, Jo, DH, Kim, JH, Comsa, C, Dragomir, MD, Neroev, V, Saakyan, S, Polyakov, V, Ushakova, TL, Yarovaya, VA, Yarovoy, AA, Theophile, T, Al Mesfer, S, Maktabi, A, Al-Dahmash, SA, Alkatan, HM, Moreira, C, Roth, PAN, Ilic, VR, Nikitovic, M, Latinovic, S, Quah, B, Tan, D, Hederova, S, Husakova, K, Groznik, AL, Pompe, MT, Davidson, A, Du Bruyn, M, Du Plessis, J, Stones, DK, Geel, JA, Myezo, KH, Kruger, M, Mayet, I, Naidu, G, Naidu, N, Mustak, H, Reynders, D, Wetter, J, Alarcon Portabella, S, Martin-Begue, N, Wolley Dod, C, Balaguer, J, Barranco, H, Catala-Mora, J, Correa Llano, MG, Fernandez-Teijeiro, A, Garcia Aldana, D, Peralta Calvo, J, San Roman Pacheco, S, Gunasekera, DS, Elhassan, MMA, Mohamedani, AA, All-Eriksson, C, Bartuma, K, Popovic, MB, Munier, FL, Liu, C-H, Chiwanga, FS, Kyara, A, Mndeme, FG, Msina, MS, Scanlan, TA, Atchaneeyasakul, L-O, Buaboonnam, J, Dangboon, W, Singha, P, Hongeng, S, Kulvichit, K, Rojanaporn, D, Surukrattanaskul, S, Wangtiraumnuay, N, Wiwatwongwana, A, Wiwatwongwana, D, Wongwai, P, Sharma, MK, Guedenon, KM, Bouguila, H, Atalay, HT, Hasanreisoglu, M, Ataseven, E, Kantar, M, Gunduz, AK, Kebudi, R, Kiratli, H, Koc, I, Tuncer, S, Unal, E, Kalinaki, A, Matua, M, Waddell, K, Musika, AA, Ssali, G, Al Harby, L, Reddy, MA, Astbury, NJ, Bascaran, C, Bowman, R, Burton, MJ, Foster, A, Zondervan, M, Sagoo, MS, Bobrova, N, Sorochynska, T, Lysytsia, L, Castillo, L, Afshar, AR, Berry, JL, Kim, JW, Randhawa, JK, Binkley, E, Boldt, HC, Larson, SA, Brennan, RC, Chandramohan, A, Stacey, AW, Corson, TW, Plager, DA, Davanzo, JM, Singh, AD, Demirci, H, Ericksen, C, Magrath, GN, Gold, AS, Murray, TG, Gonzalez, E, Shah, AS, Hansen, ED, Hartnett, ME, Harbour, JW, Hubbard, GB, Uner, OE, Laurenti, KD, Mets, MB, Leverant, AA, Ramasubramanian, A, Luna-Fineman, S, Miller, A, Skalet, AH, Mruthyunjaya, P, Hassan, M, Oliver, SC, Shields, CL, Yaghy, A, Stahl, ED, Wilson, MW, Villegas, VM, Islamov, Z, Usmanov, RH, Graells, J, Romero, L, Pham, CTM, Trang, DL, Al-Hussaini, HH, Thawaba, ADM, Muma, KIM, and Nyaywa, M
Abstract: BACKGROUND: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0-36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8-100·0) for children from high-income countries, 91·2% (89·5-93·0) for children from upper-middle-income countries, 80·3% (78·3-82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76-50·00), cT4 advanced tumour compared to
Published: 2022

7. Pneumatic tools for vitreoretinal surgery

Author: Romano MR, Vallejo-Garcia JL, Randazzo A, and Vinciguerra P.
Subjects: Ophthalmology, RE1-994
Abstract: Mario R Romano, Jose Luis Vallejo-Garcia, Alessandro Randazzo, Paolo VinciguerraIstituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, ItalyAbstract: One of the difficulties of microsurgery is learning how to control physiological tremors. The pneumatic tool eliminates the physiological tremor, but no tactile feedback is provided. The manual tremor when closing the forceps is completely eliminated and the exact target can be more easily grabbed. Forceps closure pressure can rise up to 50 psi, whereas the scissors can be used in two modes: multicut and proportional. When performing bimanual surgery the pedal range is divided into two steps: in the first step, the forceps are controlled, and in the second step, the forceps remain closed. At the same time the scissors start to work in the preselected mode. No adverse events occurred and no iatrogenic retinal breaks were produced. Precision and control sensation were a grateful surprise.Keywords: pneumatic forceps, pneumatic scissors, physiological tremor
Published: 2012

8. Case-based session: cardiac masses: Wednesday 3 December 2014, 11: 00–12: 30Location: Agora

Author: Cambronero Cortinas, E, Corbi Pascual, MJ, Sanchez Gallego, G, Cros Ruiz De Galarreta, T, Baxeiras Gonzalez, N, Fuentes Manso, R, Barambio Ruiz, M, Tercero Martinez, A, Barrionuevo Sanchez, MI, and Rodriguez Garcia, JL
Published: 2014

9. Diagnosis of Giant Cell Arteritis in Spain: Data from the ARTESER Registry

Author: De Miguel, E, Sanchez-Costa, JT, Narvaez, J, Gonzalez-Gay, M, Garrido-Punal, N, Estrada-Alarcon, PV, Hernandez-Rodriguez, I, Fernandez-Fernandez, E, Silva-Diaz, MT, Valero-Jaimes, JA, Gonzalez-Fernandez, I, Sanchez, J, Lluch, J, Galindez-Agirregoikoa, E, Mendizabal-Mateos, J, Rodriguez, LR, Garcia, JL, Munoz, A, Castaneda, S, Moya, P, Moran-Alvarez, P, Navarro-Angeles, VA, Calvet-Fontova, J, Casafont, I, Ortiz-Sanjuan, F, Labrada-Arrabal, S, Campos-Fernandez, C, Alcalde-Villar, M, Juan-Mas, A, and Blanco, R
Published: 2021

10. Predictive markers of acute focal bacterial nephritis. A multicentre case-control study

Author: Garcia, JL, Benavent, MO, Monleon, SF, Sierra, JM, Alvarez, MDR, and Julve, PB
Subjects: Acute pyelonephritis, Urinary tract malformations, Acute focal nephritis, Lobar nephronia, Procalcitonin, Predictive factors
Abstract: Introduction: Acute focal bacterial nephritis is an interstitial bacterial infection, localised in the renal parenchyma, which can be more serious than acute pyelonephritis. The aim of this study is the analysis of predictive factors that may lead to its early diagnosis, which is essential for an adequate therapeutic approach. Patients and methods: A retrospective, multicentre case and control study. The participant centres were hospitals in Castellon and Valencia. The study period was 2010-2018, with the cases being patients with focal bacterial nephritis and the patients with pyelonephritis as controls. Results: A total of 158 (1:1) patients were included. The median age of the cases was 2 years and there were 75% females. There were no differences in the clinical presentation. In the univariate analysis, focal nephritis was associated with malformations of the urinary tract, bacteraemia, the neutrophil count, and procalcitonin, as well as febrile convulsions of borderline significance. Procalcitonin values >= 2 ng/ml had an OR of 4.9 (95%CI; 1.77-13.85) of presenting with focal nephritis. In the multivariate analysis, the urological malformations still maintained statistical significance and borderline significance for procalcitonin. Conclusions: The urinary tract malformations predispose the development of focal bacterial nephritis. In patients with a urinary tract infection and predictive factors of acute focal bacterial nephritis it would be worthwhile performing a renal Doppler ultrasound in the acute phase for its appropriate diagnosis and treatment. (C) 2020 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Published: 2020

11. Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research

Author: Sanchez-Guijo, F, Garcia-Olmo, D, Prosper, F, Martinez, S, Zapata, A, Fernandez-Aviles, F, Toledo-Aral, JJ, Torres, M, Farinas, I, Badimon, L, Labandeira-Garcia, JL, Garcia-Sancho, J, and Moraleda, JM
Subjects: translational medicine, research network, stem cells, regenerative medicine, cell therapy
Abstract: In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this important area. Thirty-two research groups organized in three programs devoted to cardiovascular, neurodegenerative and immune-inflammatory diseases, respectively, currently form the network. Each program has three working packages focused on basic science, pre-clinical studies and clinical application. TerCel has contributed during this period to boost the translational research in cell therapy in Spain, setting up a network of Good Manufacturing Practicecertified cell manufacturing facilities and increasing the number of translational research projects, publications, patents and clinical trials of the participating groups, especially those in collaboration. TerCel pays particular attention to the public-private collaboration, which, for instance, has led to the development of the first allogeneic cell therapy product approved by the European Medicines Agency, Darvadstrocel. The current collaborative work is focused on the development of multicenter phase 2 and 3 trials that could translate these therapies to clinical practice for the benefit of patients. Crown Copyright (C) 2019. Published by Elsevier Inc. on behalf of International Society for Cell and Gene Therapy. All rights reserved.
Published: 2020

12. Global Retinoblastoma Presentation and Analysis by National Income Level

Author: Fabian, ID, Abdallah, E, Abdullahi, SU, Abdulqader, RA, Boubacar, SA, Ademola-Popoola, DS, Adio, A, Afshar, AR, Aggarwal, P, Aghaji, AE, Ahmad, A, Akib, MNR, Al Harby, L, Al Ani, MH, Alakbarova, A, Portabella, SA, Al-Badri, SAF, Alcasabas, APA, Al-Dahmash, SA, Alejos, A, Alemany-Rubio, E, Bio, AIA, Carreras, YA, Al-Haddad, C, Al-Hussaini, HHY, Ali, AM, Alia, DB, Al-Jadiry, MF, Al-Jumaly, U, Alkatan, HM, All-Eriksson, C, Al-Mafrachi, AARM, Almeida, AA, Alsawidi, KM, Al-Shaheen, AASM, Al-Shammary, EH, Amiruddin, PO, Antonino, R, Astbury, NJ, Atalay, HT, Atchaneeyasakul, L-O, Atsiaya, R, Attaseth, T, Aung, TH, Ayala, S, Baizakova, B, Balaguer, J, Balayeva, R, Balwierz, W, Barranco, H, Bascaran, C, Popovic, MB, Benavides, R, Benmiloud, S, Guebessi, NB, Berete, RC, Berry, JL, Bhaduri, A, Bhat, S, Biddulph, SJ, Biewald, EM, Bobrova, N, Boehme, M, Boldt, HC, Bonanomi, MTBC, Bornfeld, N, Bouda, GC, Bouguila, H, Boumedane, A, Brennan, RC, Brichard, BG, Buaboonnam, J, Calderon-Sotelo, P, Calle Jara, DA, Camuglia, JE, Cano, MR, Capra, M, Cassoux, N, Castela, G, Castillo, L, Catala-Mora, J, Chantada, GL, Chaudhry, S, Chaugule, SS, Chauhan, A, Chawla, B, Chernodrinska, VS, Chiwanga, FS, Chuluunbat, T, Cieslik, K, Cockcroft, RL, Comsa, C, Correa, ZM, Correa Llano, MG, Corson, TW, Cowan-Lyn, KE, Csoka, M, Cui, X, Da Gama, I, Dangboon, W, Das, A, Das, S, Davanzo, JM, Davidson, A, De Potter, P, Delgado, KQ, Demirci, H, Desjardins, L, Diaz Coronado, RY, Dimaras, H, Dodgshun, AJ, Donaldson, C, Donato Macedo, CR, Dragomir, MD, Du, Y, Du Bruyn, M, Edison, KS, Sutyawan, IWE, El Kettani, A, Elbahi, AM, Elder, JE, Elgalaly, D, Elhaddad, AM, Elhassan, MMA, Elzembely, MM, Essuman, VA, Evina, TGA, Fadoo, Z, Fandino, AC, Faranoush, M, Fasina, O, Fernandez, DDPG, Fernandez-Teijeiro, A, Foster, A, Frenkel, S, Fu, LD, Fuentes-Alabi, SL, Gallie, BL, Gandiwa, M, Garcia, JL, Garcia Aldana, D, Gassant, PY, Geel, JA, Ghassemi, F, Giron, A, Gizachew, Z, Goenz, MA, Gold, AS, Goldberg-Lavid, M, Gole, GA, Gomel, N, Gonzalez, E, Gonzalez Perez, G, Gonzalez-Rodriguez, L, Garcia Pacheco, HN, Graells, J, Green, L, Gregersen, PA, Grigorovski, NDAK, Guedenon, KM, Gunasekera, DS, Gunduz, AK, Gupta, H, Gupta, S, Hadjistilianou, T, Hamel, P, Hamid, SA, Hamzah, N, Hansen, ED, Harbour, JW, Hartnett, ME, Hasanreisoglu, M, Hassan, S, Hederova, S, Hernandez, J, Carcamo Hernandez, LM, Hessissen, L, Hordofa, DF, Huang, LC, Hubbard, GB, Hummlen, M, Husakova, K, Al-Janabi, ANH, Ida, R, Ilic, VR, Jairaj, V, Jeeva, I, Jenkinson, H, Ji, X, Jo, DH, Johnson, KP, Johnson, WJ, Jones, MM, Kabesha, TBA, Kabore, RL, Kaliki, S, Kalinaki, A, Kantar, M, Kao, L-Y, Kardava, T, Kebudi, R, Kepak, T, Keren-Froim, N, Khan, ZJ, Khaqan, HA, Khauv, P, Kheir, WJ, Khetan, V, Khodabande, A, Khotenashvili, Z, Kim, JW, Kim, JH, Kiratli, H, Kivela, TT, Klett, A, Palet, JEKK, Krivaitiene, D, Kruger, M, Kulvichit, K, Kuntorini, MW, Kyara, A, Lachmann, ES, Lam, CPS, Lam, GC, Larson, SA, Latinovic, S, Laurenti, KD, Le, BHA, Lecuona, K, Leverant, AA, Li, C, Limbu, B, Quah, BL, Lopez, JP, Lukamba, RM, Lumbroso, L, Luna-Fineman, S, Lutfi, D, Lysytsia, L, Magrath, GN, Mahajan, A, Majeed, AR, Maka, E, Makan, M, Makimbetov, EK, Manda, C, Martin Begue, N, Mason, L, Mason, JO, Matende, IO, Materin, M, Mattosinho, CCDS, Matua, M, Mayet, I, Mbumba, FB, McKenzie, JD, Medina-Sanson, A, Mehrvar, A, Mengesha, AA, Menon, V, Mercado, GJVD, Mets, MB, Midena, E, Mishra, DKC, Mndeme, FG, Mohamedani, AA, Mohammad, MT, Moll, AC, Montero, MM, Morales, RA, Moreira, C, Mruthyunjaya, P, Msina, MS, Msukwa, G, Mudaliar, SS, Muma, K, Munier, FL, Murgoi, G, Murray, TG, Musa, KO, Mushtaq, A, Mustak, H, Muyen, OM, Naidu, G, Nair, AG, Naumenko, L, Roth, PAN, Nency, YM, Neroev, V, Ngo, H, Nieves, RM, Nikitovic, M, Nkanga, ED, Nkumbe, H, Nuruddin, M, Nyaywa, M, Obono-Obiang, G, Oguego, NC, Olechowski, A, Oliver, SCN, Osei-Bonsu, P, Ossandon, D, Paez-Escamilla, MA, Pagarra, H, Painter, SL, Paintsil, V, Paiva, L, Pal, BP, Palanivelu, MS, Papyan, R, Parrozzani, R, Parulekar, M, Morales, CRP, Paton, KE, Pawinska-Wasikowska, K, Pe'er, J, Pena, A, Peric, S, Pham, CTM, Philbert, R, Plager, DA, Pochop, P, Polania, RA, Polyakov, VG, Pompe, MT, Pons, JJ, Prat, D, Prom, V, Purwanto, I, Qadir, AO, Qayyum, S, Qian, J, Rahman, A, Rahman, S, Rahmat, J, Rajkarnikar, P, Ramanjulu, R, Ramasubramanian, A, Ramirez-Ortiz, MA, Raobela, L, Rashid, R, Reddy, MA, Reich, E, Renner, LA, Reynders, D, Ribadu, D, Riheia, MM, Ritter-Sovinz, P, Rojanaporn, D, Romero, L, Roy, SR, Saab, RH, Saakyan, S, Sabhan, AH, Sagoo, MS, Said, AMA, Saiju, R, Salas, B, San Roman Pacheco, S, Sanchez, GL, Sayalith, P, Scanlan, TA, Schefler, AC, Schoeman, J, Sedaghat, A, Seregard, S, Seth, R, Shah, AS, Shakoor, SA, Sharma, MK, Sherief, ST, Shetye, NG, Shields, CL, Siddiqui, SN, Cheikh, SS, Silva, S, Singh, AD, Singh, N, Singh, U, Singha, P, Sitorus, RS, Skalet, AH, Soebagjo, HD, Sorochynska, T, Ssali, G, Stacey, AW, Staffieri, SE, Stahl, ED, Stathopoulos, C, Kranjc, BS, Stones, DK, Strahlendorf, C, Suarez, MEC, Sultana, S, Sun, X, Sundy, M, Superstein, R, Supriyadi, E, Surukrattanaskul, S, Suzuki, S, Svojgr, K, Sylla, F, Tamamyan, G, Tan, D, Tandili, A, Tarrillo Leiva, FF, Tashvighi, M, Tateshi, B, Tehuteru, ES, Teixeira, LF, Teh, KH, Theophile, T, Toledano, H, Trang, DL, Traore, F, Trichaiyaporn, S, Tuncer, S, Tyau-Tyau, H, Umar, AB, Unal, E, Uner, OE, Urbak, SF, Ushakova, TL, Usmanov, RH, Valeina, S, Wijsard, MVH, Varadisai, A, Vasquez, L, Vaughan, LO, Veleva-Krasteva, NV, Verma, N, Victor, AA, Viksnins, M, Villacos Chafla, EG, Vishnevskia-Dai, V, Vora, T, Wachtel, AE, Wackernagel, W, Waddell, K, Wade, PD, Wali, AH, Wang, Y-Z, Weiss, A, Wilson, MW, Wime, ADC, Wiwatwongwana, A, Wiwatwongwana, D, Dod, CW, Wongwai, P, Xiang, D, Xiao, Y, Yam, JC, Yang, H, Yanga, JM, Yaqub, MA, Yarovaya, VA, Yarovoy, AA, Ye, H, Yousef, YA, Yuliawati, P, Zapata Lopez, AM, Zein, E, Zhang, C, Zhang, Y, Zhao, J, Zheng, X, Zhilyaeva, K, Zia, N, Ziko, OAO, Zondervan, M, Bowman, R, Fabian, ID, Abdallah, E, Abdullahi, SU, Abdulqader, RA, Boubacar, SA, Ademola-Popoola, DS, Adio, A, Afshar, AR, Aggarwal, P, Aghaji, AE, Ahmad, A, Akib, MNR, Al Harby, L, Al Ani, MH, Alakbarova, A, Portabella, SA, Al-Badri, SAF, Alcasabas, APA, Al-Dahmash, SA, Alejos, A, Alemany-Rubio, E, Bio, AIA, Carreras, YA, Al-Haddad, C, Al-Hussaini, HHY, Ali, AM, Alia, DB, Al-Jadiry, MF, Al-Jumaly, U, Alkatan, HM, All-Eriksson, C, Al-Mafrachi, AARM, Almeida, AA, Alsawidi, KM, Al-Shaheen, AASM, Al-Shammary, EH, Amiruddin, PO, Antonino, R, Astbury, NJ, Atalay, HT, Atchaneeyasakul, L-O, Atsiaya, R, Attaseth, T, Aung, TH, Ayala, S, Baizakova, B, Balaguer, J, Balayeva, R, Balwierz, W, Barranco, H, Bascaran, C, Popovic, MB, Benavides, R, Benmiloud, S, Guebessi, NB, Berete, RC, Berry, JL, Bhaduri, A, Bhat, S, Biddulph, SJ, Biewald, EM, Bobrova, N, Boehme, M, Boldt, HC, Bonanomi, MTBC, Bornfeld, N, Bouda, GC, Bouguila, H, Boumedane, A, Brennan, RC, Brichard, BG, Buaboonnam, J, Calderon-Sotelo, P, Calle Jara, DA, Camuglia, JE, Cano, MR, Capra, M, Cassoux, N, Castela, G, Castillo, L, Catala-Mora, J, Chantada, GL, Chaudhry, S, Chaugule, SS, Chauhan, A, Chawla, B, Chernodrinska, VS, Chiwanga, FS, Chuluunbat, T, Cieslik, K, Cockcroft, RL, Comsa, C, Correa, ZM, Correa Llano, MG, Corson, TW, Cowan-Lyn, KE, Csoka, M, Cui, X, Da Gama, I, Dangboon, W, Das, A, Das, S, Davanzo, JM, Davidson, A, De Potter, P, Delgado, KQ, Demirci, H, Desjardins, L, Diaz Coronado, RY, Dimaras, H, Dodgshun, AJ, Donaldson, C, Donato Macedo, CR, Dragomir, MD, Du, Y, Du Bruyn, M, Edison, KS, Sutyawan, IWE, El Kettani, A, Elbahi, AM, Elder, JE, Elgalaly, D, Elhaddad, AM, Elhassan, MMA, Elzembely, MM, Essuman, VA, Evina, TGA, Fadoo, Z, Fandino, AC, Faranoush, M, Fasina, O, Fernandez, DDPG, Fernandez-Teijeiro, A, Foster, A, Frenkel, S, Fu, LD, Fuentes-Alabi, SL, Gallie, BL, Gandiwa, M, Garcia, JL, Garcia Aldana, D, Gassant, PY, Geel, JA, Ghassemi, F, Giron, A, Gizachew, Z, Goenz, MA, Gold, AS, Goldberg-Lavid, M, Gole, GA, Gomel, N, Gonzalez, E, Gonzalez Perez, G, Gonzalez-Rodriguez, L, Garcia Pacheco, HN, Graells, J, Green, L, Gregersen, PA, Grigorovski, NDAK, Guedenon, KM, Gunasekera, DS, Gunduz, AK, Gupta, H, Gupta, S, Hadjistilianou, T, Hamel, P, Hamid, SA, Hamzah, N, Hansen, ED, Harbour, JW, Hartnett, ME, Hasanreisoglu, M, Hassan, S, Hederova, S, Hernandez, J, Carcamo Hernandez, LM, Hessissen, L, Hordofa, DF, Huang, LC, Hubbard, GB, Hummlen, M, Husakova, K, Al-Janabi, ANH, Ida, R, Ilic, VR, Jairaj, V, Jeeva, I, Jenkinson, H, Ji, X, Jo, DH, Johnson, KP, Johnson, WJ, Jones, MM, Kabesha, TBA, Kabore, RL, Kaliki, S, Kalinaki, A, Kantar, M, Kao, L-Y, Kardava, T, Kebudi, R, Kepak, T, Keren-Froim, N, Khan, ZJ, Khaqan, HA, Khauv, P, Kheir, WJ, Khetan, V, Khodabande, A, Khotenashvili, Z, Kim, JW, Kim, JH, Kiratli, H, Kivela, TT, Klett, A, Palet, JEKK, Krivaitiene, D, Kruger, M, Kulvichit, K, Kuntorini, MW, Kyara, A, Lachmann, ES, Lam, CPS, Lam, GC, Larson, SA, Latinovic, S, Laurenti, KD, Le, BHA, Lecuona, K, Leverant, AA, Li, C, Limbu, B, Quah, BL, Lopez, JP, Lukamba, RM, Lumbroso, L, Luna-Fineman, S, Lutfi, D, Lysytsia, L, Magrath, GN, Mahajan, A, Majeed, AR, Maka, E, Makan, M, Makimbetov, EK, Manda, C, Martin Begue, N, Mason, L, Mason, JO, Matende, IO, Materin, M, Mattosinho, CCDS, Matua, M, Mayet, I, Mbumba, FB, McKenzie, JD, Medina-Sanson, A, Mehrvar, A, Mengesha, AA, Menon, V, Mercado, GJVD, Mets, MB, Midena, E, Mishra, DKC, Mndeme, FG, Mohamedani, AA, Mohammad, MT, Moll, AC, Montero, MM, Morales, RA, Moreira, C, Mruthyunjaya, P, Msina, MS, Msukwa, G, Mudaliar, SS, Muma, K, Munier, FL, Murgoi, G, Murray, TG, Musa, KO, Mushtaq, A, Mustak, H, Muyen, OM, Naidu, G, Nair, AG, Naumenko, L, Roth, PAN, Nency, YM, Neroev, V, Ngo, H, Nieves, RM, Nikitovic, M, Nkanga, ED, Nkumbe, H, Nuruddin, M, Nyaywa, M, Obono-Obiang, G, Oguego, NC, Olechowski, A, Oliver, SCN, Osei-Bonsu, P, Ossandon, D, Paez-Escamilla, MA, Pagarra, H, Painter, SL, Paintsil, V, Paiva, L, Pal, BP, Palanivelu, MS, Papyan, R, Parrozzani, R, Parulekar, M, Morales, CRP, Paton, KE, Pawinska-Wasikowska, K, Pe'er, J, Pena, A, Peric, S, Pham, CTM, Philbert, R, Plager, DA, Pochop, P, Polania, RA, Polyakov, VG, Pompe, MT, Pons, JJ, Prat, D, Prom, V, Purwanto, I, Qadir, AO, Qayyum, S, Qian, J, Rahman, A, Rahman, S, Rahmat, J, Rajkarnikar, P, Ramanjulu, R, Ramasubramanian, A, Ramirez-Ortiz, MA, Raobela, L, Rashid, R, Reddy, MA, Reich, E, Renner, LA, Reynders, D, Ribadu, D, Riheia, MM, Ritter-Sovinz, P, Rojanaporn, D, Romero, L, Roy, SR, Saab, RH, Saakyan, S, Sabhan, AH, Sagoo, MS, Said, AMA, Saiju, R, Salas, B, San Roman Pacheco, S, Sanchez, GL, Sayalith, P, Scanlan, TA, Schefler, AC, Schoeman, J, Sedaghat, A, Seregard, S, Seth, R, Shah, AS, Shakoor, SA, Sharma, MK, Sherief, ST, Shetye, NG, Shields, CL, Siddiqui, SN, Cheikh, SS, Silva, S, Singh, AD, Singh, N, Singh, U, Singha, P, Sitorus, RS, Skalet, AH, Soebagjo, HD, Sorochynska, T, Ssali, G, Stacey, AW, Staffieri, SE, Stahl, ED, Stathopoulos, C, Kranjc, BS, Stones, DK, Strahlendorf, C, Suarez, MEC, Sultana, S, Sun, X, Sundy, M, Superstein, R, Supriyadi, E, Surukrattanaskul, S, Suzuki, S, Svojgr, K, Sylla, F, Tamamyan, G, Tan, D, Tandili, A, Tarrillo Leiva, FF, Tashvighi, M, Tateshi, B, Tehuteru, ES, Teixeira, LF, Teh, KH, Theophile, T, Toledano, H, Trang, DL, Traore, F, Trichaiyaporn, S, Tuncer, S, Tyau-Tyau, H, Umar, AB, Unal, E, Uner, OE, Urbak, SF, Ushakova, TL, Usmanov, RH, Valeina, S, Wijsard, MVH, Varadisai, A, Vasquez, L, Vaughan, LO, Veleva-Krasteva, NV, Verma, N, Victor, AA, Viksnins, M, Villacos Chafla, EG, Vishnevskia-Dai, V, Vora, T, Wachtel, AE, Wackernagel, W, Waddell, K, Wade, PD, Wali, AH, Wang, Y-Z, Weiss, A, Wilson, MW, Wime, ADC, Wiwatwongwana, A, Wiwatwongwana, D, Dod, CW, Wongwai, P, Xiang, D, Xiao, Y, Yam, JC, Yang, H, Yanga, JM, Yaqub, MA, Yarovaya, VA, Yarovoy, AA, Ye, H, Yousef, YA, Yuliawati, P, Zapata Lopez, AM, Zein, E, Zhang, C, Zhang, Y, Zhao, J, Zheng, X, Zhilyaeva, K, Zia, N, Ziko, OAO, Zondervan, M, and Bowman, R
Abstract: IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. DESIGN, SETTING, AND PARTICIPANTS: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. MAIN OUTCOMES AND MEASURES: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. RESULTS: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis
Published: 2020

13. The dynamic geophysical environment of (101955) Bennu based on OSIRIS-REx measurements

Author: Scheeres, DJ, McMahon, JW, French, AS, Brack, DN, Chesley, SR, Farnocchia, D, Takahashi, Y, Leonard, JM, Geeraert, J, Page, B, Antreasian, P, Getzandanner, K, Rowlands, D, Mazarico, EM, Small, J, Highsmith, DE, Moreau, M, Emery, JP, Rozitis, B, Hirabayashi, M, Sanchez, P, Van Wal, S, Tricarico, P, Ballouz, R-L, Johnson, CL, Asad, MM, Susorney, HCM, Barnouin, OS, Daly, MG, Seabrook, JA, Gaskell, RW, Palmer, EE, Weirich, JR, Walsh, KJ, Jawin, ER, Bierhaus, EB, Michel, P, Bottke, WF, Nolan, MC, Jr, CHC, Lauretta, DS, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Stromberg, J, Hartzell, CM, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, McGraw, L, Ghent, R, Binzel, RP, Philpott, L, Cloutis, EA, Hanna, RD, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Clark, BE, Ferrone, S, Thomas, CA, Campins, H, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, Izawa, MRM, De Leon, J, Licandro, J, Garcia, JL, Clemett, S, Thomas-Keprta, K, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Velez, D, Yetter, K, Thayer, C, Adam, C, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Hoffman, J, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Barucci, MA, Deshapriya, JDP, Fornasier, S, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, WV, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, D'Aubigny, CYD, Dean, D, Dellagiustina, DN, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Golish, DR, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Hergenrother, CW, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Howell, ES, Huettner, E, Janakus, A, Jones, J, Kareta, TR, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, CK, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Rizk, B, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Smith, PH, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CWV, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S-I, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mink, R, Moore, W, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Le Corre, L, Li, J-Y, Molaro, JL, Siegler, MA, Zou, X-D, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Beddingfield, CB, Marshall, J, McCoy, TJ, Russell, S, Killgore, M, Hamilton, VE, Kaplan, HH, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Freemantle, J, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo', M, Libourel, G, Ryan, A, Thuillet, F, Marty, B, Team, The OSIRIS-REx, USDA Agricultural Research Service [Maricopa, AZ] (USDA), United States Department of Agriculture (USDA), Dipartimento di Matematica, University of Pisa - Università di Pisa, Department of Geophysics [Sendai], Tohoku University [Sendai], KinetX Aerospace Inc., Institut de Recherche Interdisciplinaire sur les enjeux Sociaux - sciences sociales, politique, santé (IRIS), Université Paris 13 (UP13)-École des hautes études en sciences sociales (EHESS)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris sciences et lettres (PSL), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), The Open University [Milton Keynes] (OU), National Institute of Polar Research [Tokyo] (NiPR), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Planetary Science Institute [Tucson] (PSI), Institute of Northern Engineering, 455 Duckering Bldg, Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-École des hautes études en sciences sociales (EHESS)-Université Paris 13 (UP13), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: 010504 meteorology & atmospheric sciences, biology, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Physics, Spin rate, Equator, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astronomy and Astrophysics, Geophysics, Astronomy and planetary science, biology.organism_classification, 01 natural sciences, Article, [SPI]Engineering Sciences [physics], Engineering, Asteroid, 0103 physical sciences, Roche lobe, Osiris, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract: 著者人数: 41名ほか (The OSIRIS-REx Team: 所属. 宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS): Van wal, Stefaan; 吉川, 真; 渡邊, 誠一郎), Number of authors: 41 and The OSIRIS-REx Team (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS): Yoshikawa, Makoto; Watanabe, Sei-ichiro), Accepted: 2019-02-11, 資料番号: SA1180379000
Published: 2019

14. Properties of rubble-pile asteroid (101955) Bennu from OSIRIS-REx imaging and thermal analysis

Author: Dellagiustina, DN, Emery, JP, Golish, DR, Rozitis, B, Bennett, CA, Burke, KN, Ballouz, R-L, Becker, KJ, Christensen, PR, D'Aubigny, CYD, Hamilton, VE, Reuter, DC, Rizk, B, Simon, AA, Asphaug, E, Bandfield, JL, Barnouin, OS, Barucci, MA, Bierhaus, EB, Binzel, RP, Bottke, WF, Bowles, NE, Campins, H, Clark, BC, Clark, BE, Jr, CHC, Daly, MG, De Leon, J, Delbo', M, Deshapriya, JDP, Elder, CM, Fornasier, S, Hergenrother, CW, Howell, ES, Jawin, ER, Kaplan, HH, Kareta, TR, Le Corre, L, Li, J-Y, Licandro, J, Lim, LF, Michel, P, Molaro, J, Nolan, MC, Pajola, M, Popescu, M, Garcia, JL, Ryan, A, Schwartz, SR, Shultz, N, Siegler, MA, Smith, PH, Tatsumi, E, Thomas, CA, Walsh, KJ, Wolner, CWV, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Hartzell, CM, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, McGraw, L, Ghent, R, Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Cloutis, EA, Hanna, RD, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, Izawa, MRM, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Chesley, SR, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Audi, E, Bandrowski, R, Becker, TL, Bendall, S, Bloomenthal, H, Blum, D, Boynton, WV, Brodbeck, J, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Maleszewski, CK, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Selznick, S, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S-I, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Molaro, JL, Palmer, EE, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Scheeres, DJ, McCoy, TJ, Russell, S, Killgore, M, Chodas, M, Lambert, M, Masterson, RA, Freemantle, J, Seabrook, JA, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Libourel, G, Thuillet, F, Marty, B, Team, OSIRIS-REx, The Open University [Milton Keynes] (OU), Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, ASU School of Earth and Space Exploration (SESE), Arizona State University [Tempe] (ASU), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), University of Oxford [Oxford], Dept. of Physics, University of Central Florida [Orlando], IHU-LIRYC, CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Planetary Science Institute [Tucson] (PSI), Instituto de Astrofisica de Canarias (IAC), Institute of Northern Engineering, 455 Duckering Bldg, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Laboratoire de Géophysique Interne et Tectonophysique (LGIT), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Laboratoire Central des Ponts et Chaussées (LCPC)-Institut des Sciences de la Terre (ISTerre), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers (INSU - CNRS)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Centre de Mise en Forme des Matériaux (CEMEF), Centre National de la Recherche Scientifique (CNRS)-PSL Research University (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Central Florida [Orlando] (UCF), Institut des Sciences de la Terre (ISTerre), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI (2016)
Subjects: 010504 meteorology & atmospheric sciences, Spacecraft, business.industry, Rubble, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astronomy and Astrophysics, Astronomy and planetary science, engineering.material, Albedo, 01 natural sciences, Regolith, Parent body, Astrobiology, [SPI]Engineering Sciences [physics], Planetary science, Asteroid, 0103 physical sciences, engineering, Particle, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, 010303 astronomy & astrophysics, Geology, 0105 earth and related environmental sciences
Abstract: 著者人数: 58名ほか (The OSIRIS-REx Team: 所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): Van wal, S; 吉川, 真; 渡邊, 誠一郎), Number of authors: 58 and The OSIRIS-REx Team (Affiliation. Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency(JAXA)(ISAS): Van wal, S; Yoshikawa, Makoto; Watanabe, Sei-icihro), Accepted: 2019-02-19, 資料番号: SA1190037000
Published: 2019

15. The urgent need for microbiology literacy in society

Author: Timmis, K, Cavicchioli, R, Garcia, JL, Nogales, B, Chavarría, M, Stein, L, McGenity, TJ, Webster, N, Singh, BK, Handelsman, J, de Lorenzo, V, Pruzzo, C, Timmis, J, Martín, JLR, Verstraete, W, Jetten, M, Danchin, A, Huang, W, Gilbert, J, Lal, R, Santos, H, Lee, SY, Sessitsch, A, Bonfante, P, Gram, L, Lin, RTP, Ron, E, Karahan, ZC, van der Meer, JR, Artunkal, S, Jahn, D, Harper, L, Timmis, K, Cavicchioli, R, Garcia, JL, Nogales, B, Chavarría, M, Stein, L, McGenity, TJ, Webster, N, Singh, BK, Handelsman, J, de Lorenzo, V, Pruzzo, C, Timmis, J, Martín, JLR, Verstraete, W, Jetten, M, Danchin, A, Huang, W, Gilbert, J, Lal, R, Santos, H, Lee, SY, Sessitsch, A, Bonfante, P, Gram, L, Lin, RTP, Ron, E, Karahan, ZC, van der Meer, JR, Artunkal, S, Jahn, D, and Harper, L
Published: 2019

16. The operational environment and rotational acceleration of asteroid (101955) Bennu from OSIRIS-REx observations

Author: Hergenrother, CW, Maleszewski, CK, Nolan, MC, Li, J-Y, d'Aubigny, CYD, Shelly, FC, Howell, ES, Kareta, TR, Izawa, MRM, Barucci, MA, Bierhaus, EB, Campins, H, Chesley, SR, Clark, BE, Christensen, EJ, DellaGiustina, DN, Fornasier, S, Golish, DR, Hartzell, CM, Rizk, B, Scheeres, DJ, Smith, PH, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, Emery, JP, McGraw, L, Ghent, R, Binzel, RP, Al Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Cloutis, EA, Hanna, RD, Connolly, HC, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Thomas, CA, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, de Leon, J, Licandro, J, Rizos Garcia, JL, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Deshapriya, JDP, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Ballouz, R-L, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, W, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CW, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Molaro, JL, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Rozitis, B, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Jawin, ER, McCoy, TJ, Russell, S, Killgore, M, Bottke, WF, Hamilton, VE, Kaplan, HH, Walsh, KJ, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Daly, MG, Freemantle, J, Seabrook, JA, Barnouin, OS, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Michel, P, Ryan, A, Thuillet, F, Marty, B, Hergenrother, CW, Maleszewski, CK, Nolan, MC, Li, J-Y, d'Aubigny, CYD, Shelly, FC, Howell, ES, Kareta, TR, Izawa, MRM, Barucci, MA, Bierhaus, EB, Campins, H, Chesley, SR, Clark, BE, Christensen, EJ, DellaGiustina, DN, Fornasier, S, Golish, DR, Hartzell, CM, Rizk, B, Scheeres, DJ, Smith, PH, Zou, X-D, Lauretta, DS, Highsmith, DE, Small, J, Vokrouhlicky, D, Bowles, NE, Brown, E, Hanna, KLD, Warren, T, Brunet, C, Chicoine, RA, Desjardins, S, Gaudreau, D, Haltigin, T, Millington-Veloza, S, Rubi, A, Aponte, J, Gorius, N, Lunsford, A, Allen, B, Grindlay, J, Guevel, D, Hoak, D, Hong, J, Schrader, DL, Bayron, J, Golubov, O, Sanchez, P, Stromberg, J, Hirabayashi, M, Oliver, S, Rascon, M, Harch, A, Joseph, J, Squyres, S, Richardson, D, Emery, JP, McGraw, L, Ghent, R, Binzel, RP, Al Asad, MM, Johnson, CL, Philpott, L, Susorney, HCM, Cloutis, EA, Hanna, RD, Connolly, HC, Ciceri, F, Hildebrand, AR, Ibrahim, E-M, Breitenfeld, L, Glotch, T, Rogers, AD, Ferrone, S, Thomas, CA, Fernandez, Y, Chang, W, Cheuvront, A, Trang, D, Tachibana, S, Yurimoto, H, Brucato, JR, Poggiali, G, Pajola, M, Dotto, E, Epifani, EM, Crombie, MK, Lantz, C, de Leon, J, Licandro, J, Rizos Garcia, JL, Clemett, S, Thomas-Keprta, K, Van Wal, S, Yoshikawa, M, Bellerose, J, Bhaskaran, S, Boyles, C, Elder, CM, Farnocchia, D, Harbison, A, Kennedy, B, Knight, A, Martinez-Vlasoff, N, Mastrodemos, N, McElrath, T, Owen, W, Park, R, Rush, B, Swanson, L, Takahashi, Y, Velez, D, Yetter, K, Thayer, C, Adam, C, Antreasian, P, Bauman, J, Bryan, C, Carcich, B, Corvin, M, Geeraert, J, Hoffman, J, Leonard, JM, Lessac-Chenen, E, Levine, A, McAdams, J, McCarthy, L, Nelson, D, Page, B, Pelgrift, J, Sahr, E, Stakkestad, K, Stanbridge, D, Wibben, D, Williams, B, Williams, K, Wolff, P, Hayne, P, Kubitschek, D, Deshapriya, JDP, Fulchignoni, M, Hasselmann, P, Merlin, F, Praet, A, Billett, O, Boggs, A, Buck, B, Carlson-Kelly, S, Cerna, J, Chaffin, K, Church, E, Coltrin, M, Daly, J, Deguzman, A, Dubisher, R, Eckart, D, Ellis, D, Falkenstern, P, Fisher, A, Fisher, ME, Fleming, P, Fortney, K, Francis, S, Freund, S, Gonzales, S, Haas, P, Hasten, A, Hauf, D, Hilbert, A, Howell, D, Jaen, F, Jayakody, N, Jenkins, M, Johnson, K, Lefevre, M, Ma, H, Mario, C, Martin, K, May, C, McGee, M, Miller, B, Miller, C, Miller, G, Mirfakhrai, A, Muhle, E, Norman, C, Olds, R, Parish, C, Ryle, M, Schmitzer, M, Sherman, P, Skeen, M, Susak, M, Sutter, B, Tran, Q, Welch, C, Witherspoon, R, Wood, J, Zareski, J, Arvizu-Jakubicki, M, Asphaug, E, Audi, E, Ballouz, R-L, Bandrowski, R, Becker, KJ, Becker, TL, Bendall, S, Bennett, CA, Bloomenthal, H, Blum, D, Boynton, W, Brodbeck, J, Burke, KN, Chojnacki, M, Colpo, A, Contreras, J, Cutts, J, Dean, D, Diallo, B, Drinnon, D, Drozd, K, Enos, HL, Enos, R, Fellows, C, Ferro, T, Fisher, MR, Fitzgibbon, G, Fitzgibbon, M, Forelli, J, Forrester, T, Galinsky, I, Garcia, R, Gardner, A, Habib, N, Hamara, D, Hammond, D, Hanley, K, Harshman, K, Herzog, K, Hill, D, Hoekenga, C, Hooven, S, Huettner, E, Janakus, A, Jones, J, Kidd, J, Kingsbury, K, Balram-Knutson, SS, Koelbel, L, Kreiner, J, Lambert, D, Lewin, C, Lovelace, B, Loveridge, M, Lujan, M, Malhotra, R, Marchese, K, McDonough, E, Mogk, N, Morrison, V, Morton, E, Munoz, R, Nelson, J, Padilla, J, Pennington, R, Polit, A, Ramos, N, Reddy, V, Riehl, M, Roper, HL, Salazar, S, Schwartz, SR, Selznick, S, Shultz, N, Stewart, S, Sutton, S, Swindle, T, Tang, YH, Westermann, M, Wolner, CW, Worden, D, Zega, T, Zeszut, Z, Bjurstrom, A, Bloomquist, L, Dickinson, C, Keates, E, Liang, J, Nifo, V, Taylor, A, Teti, F, Caplinger, M, Bowles, H, Carter, S, Dickenshied, S, Doerres, D, Fisher, T, Hagee, W, Hill, J, Miner, M, Noss, D, Piacentine, N, Smith, M, Toland, A, Wren, P, Bernacki, M, Munoz, DP, Watanabe, S, Sandford, SA, Aqueche, A, Ashman, B, Barker, M, Bartels, A, Berry, K, Bos, B, Burns, R, Calloway, A, Carpenter, R, Castro, N, Cosentino, R, Donaldson, J, Dworkin, JP, Cook, JE, Emr, C, Everett, D, Fennell, D, Fleshman, K, Folta, D, Gallagher, D, Garvin, J, Getzandanner, K, Glavin, D, Hull, S, Hyde, K, Ido, H, Ingegneri, A, Jones, N, Kaotira, P, Lim, LF, Liounis, A, Lorentson, C, Lorenz, D, Lyzhoft, J, Mazarico, EM, Mink, R, Moore, W, Moreau, M, Mullen, S, Nagy, J, Neumann, G, Nuth, J, Poland, D, Reuter, DC, Rhoads, L, Rieger, S, Rowlands, D, Sallitt, D, Scroggins, A, Shaw, G, Simon, AA, Swenson, J, Vasudeva, P, Wasser, M, Zellar, R, Grossman, J, Johnston, G, Morris, M, Wendel, J, Burton, A, Keller, LP, McNamara, L, Messenger, S, Nakamura-Messenger, K, Nguyen, A, Righter, K, Queen, E, Bellamy, K, Dill, K, Gardner, S, Giuntini, M, Key, B, Kissell, J, Patterson, D, Vaughan, D, Wright, B, Gaskell, RW, Le Corre, L, Molaro, JL, Palmer, EE, Siegler, MA, Tricarico, P, Weirich, JR, Ireland, T, Tait, K, Bland, P, Anwar, S, Bojorquez-Murphy, N, Christensen, PR, Haberle, CW, Mehall, G, Rios, K, Franchi, I, Rozitis, B, Beddingfield, CB, Marshall, J, Brack, DN, French, AS, McMahon, JW, Jawin, ER, McCoy, TJ, Russell, S, Killgore, M, Bottke, WF, Hamilton, VE, Kaplan, HH, Walsh, KJ, Bandfield, JL, Clark, BC, Chodas, M, Lambert, M, Masterson, RA, Daly, MG, Freemantle, J, Seabrook, JA, Barnouin, OS, Craft, K, Daly, RT, Ernst, C, Espiritu, RC, Holdridge, M, Jones, M, Nair, AH, Nguyen, L, Peachey, J, Perry, ME, Plescia, J, Roberts, JH, Steele, R, Turner, R, Backer, J, Edmundson, K, Mapel, J, Milazzo, M, Sides, S, Manzoni, C, May, B, Delbo, M, Libourel, G, Michel, P, Ryan, A, Thuillet, F, and Marty, B
Abstract: During its approach to asteroid (101955) Bennu, NASA's Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft surveyed Bennu's immediate environment, photometric properties, and rotation state. Discovery of a dusty environment, a natural satellite, or unexpected asteroid characteristics would have had consequences for the mission's safety and observation strategy. Here we show that spacecraft observations during this period were highly sensitive to satellites (sub-meter scale) but reveal none, although later navigational images indicate that further investigation is needed. We constrain average dust production in September 2018 from Bennu's surface to an upper limit of 150 g s-1 averaged over 34 min. Bennu's disk-integrated photometric phase function validates measurements from the pre-encounter astronomical campaign. We demonstrate that Bennu's rotation rate is accelerating continuously at 3.63 ± 0.52 × 10-6 degrees day-2, likely due to the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect, with evolutionary implications.
Published: 2019

17. Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma

Author: Siebert, C, Ciato, D, Murakami, M, Frei-Stuber, L, Perez-Rivas, LG, Monteserin-Garcia, JL, Nolting, S, Maurer, J, Feuchtinger, A, Walch, AK, Haak, HR, Bertherat, J, Mannelli, M, Fassnacht, M, Korpershoek, Esther, Reincke, M, Stalla, GK, Hantel, C, Beuschlein, F, Siebert, C, Ciato, D, Murakami, M, Frei-Stuber, L, Perez-Rivas, LG, Monteserin-Garcia, JL, Nolting, S, Maurer, J, Feuchtinger, A, Walch, AK, Haak, HR, Bertherat, J, Mannelli, M, Fassnacht, M, Korpershoek, Esther, Reincke, M, Stalla, GK, Hantel, C, and Beuschlein, F
Published: 2019

18. ESRA19-0665 Infraclavicular block for elbow surgery in quadriplegic patient with previous history of autonomic dysrreflexia

Author: Garcia, J, primary, Carrion Garcia, JL, additional, and Boix, E, additional
Published: 2019
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19. The future of metabolomics in ELIXIR

Author: van Rijswijk, M, Beirnaert, C, Caron, C, Cascante, M, Dominguez, V, Dunn, WB, Ebbels, TMD, Giacomoni, F, Gonzalez-Beltran, A, Hankemeier, T, Haug, K, Izquierdo-Garcia, JL, Jimenez, RC, Jourdan, F, Kale, N, Klapa, MI, Kohlbacher, O, Koort, K, Kultima, K, Le Corguillé, G, Moreno, P, Moschonas, NK, Neumann, S, O'Donovan, C, Reczko, M, Rocca-Serra, P, Rosato, A, Salek, RM, Sansone, S-A, Satagopam, V, Schober, D, Shimmo, R, Spicer, RA, Spjuth, O, Thévenot, EA, Viant, MR, Weber, RJM, Willighagen, EL, Zanetti, G, Steinbeck, C, Dutch Techcentre for Life Sciences [Utrecht], Netherlands Metabolomics Centre, Department of Mathematics and Computer Science, ADReM, University of Antwerp (UA), French Institute of Bioinformatics (ELIXIR-FR), Department of Biochemistry and Molecular Biomedicine, Faculty of Science and Technology, Biochemistry and Molecular Biology, University of Barcelona, Birmingham Metabolomics Training Centre, University of Birmingham, Department of Surgery and Cancer, Imperial College London, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), MetaboHUB, Oxford e-Research Centre, University of Oxford, Leiden Academic Centre for Drug Research (LACDR), Universiteit Leiden, European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Centro Nacional de Investigaciones Cardiovasculares, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), ELIXIR Hub [Cambridge], Métabolisme et Xénobiotiques (ToxAlim-MeX), ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Forth ICE-HT, Institute of Chemical Engineering Sciences, Foundation for Research and Technology - Hellas (FORTH), Max Planck Institute for Developmental Biology, Max-Planck-Gesellschaft, Department of Computer Science, Duke University [Durham], Center for Bioinformatics, University of Tübingen, The Centre of Excellence in Neural and Behavioural Sciences, Tallinn University, School of Natural Sciences and Health, Department of Medical Sciences (University of Miyasaki), University of Miyasaki, ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (ABIMS), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS), Department of General Biology, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG), University of Patras, Department of Stress and Developmental Biology, Leibniz Institute of Plant Biochemistry (IPB), BSRC 'Alexander Fleming', Magnetic Resonance Center/Interuniversity Consortium of Magnetic Resonance Metalloproteins, Università degli Studi di Firenze = University of Florence (UniFI), Luxembourg Centre For Systems Biomedicine (LCSB), University of Luxembourg [Luxembourg], Université du Luxembourg (Uni.lu), Department of Pharmaceutical Biosciences, Uppsala University, Laboratoire Sciences des Données et de la Décision (LS2D), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Department of Bioinformatics, BiGCaT, Maastricht University [Maastricht], NUTRIM, Data-Intensive Computing, CRS4 Bioinformat, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], ANR-11-INBS-0010,METABOHUB,Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation(2011), European Project: 654241,H2020,H2020-EINFRA-2014-2,PhenoMeNal(2015), European Commission, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Leiden University, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), ABiMS - Informatique et bioinformatique = Analysis and Bioinformatics for Marine Science (FR2424), Université Pierre et Marie Curie (Paris 6), Federal University of Minas Gerais Belo Horizonte, University of Patras [Patras], University of Florence (UNIFI), Laboratoire d'analyse des données et d'intelligence des systèmes (LADIS), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Maastricht University, Friedrich-Schiller-Universität Jena, ANR-11-INBS-0010/11-INBS-0010,METABOHUB,Développement d’une infrastructure française distribuée pour la métabolomique dédiée à l’innovation(2011), Commission of the European Communities, European Molecular Biology Laboratory, Apollo-University Of Cambridge Repository, van Rijswijk, Merlijn [0000-0002-1067-7766], Beirnaert, Charlie [0000-0003-3007-2569], Gonzalez-Beltran, Alejandra [0000-0003-3499-8262], Haug, Kenneth [0000-0003-3168-4145], Jimenez, Rafael C [0000-0001-5404-7670], Kale, Namrata [0000-0002-4255-8104], Klapa, Maria I [0000-0002-2047-3185], Moschonas, Nicholas K [0000-0002-2556-537X], Rosato, Antonio [0000-0001-6172-0368], Salek, Reza M [0000-0001-8604-1732], Sansone, Susanna-Assunta [0000-0001-5306-5690], Schober, Daniel [0000-0001-8014-6648], Spicer, Rachel A [0000-0002-2807-8796], Spjuth, Ola [0000-0002-8083-2864], Thévenot, Etienne A [0000-0003-1019-4577], Willighagen, Egon L [0000-0001-7542-0286], Steinbeck, Christoph [0000-0001-6966-0814], Apollo - University of Cambridge Repository, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Bioinformatica, RS: NUTRIM - R4 - Gene-environment interaction, University of Oxford [Oxford], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Università degli Studi di Firenze = University of Florence [Firenze], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
Subjects: 0301 basic medicine, databases, Data management, computational workflows, infrastructure en ligne, Cloud computing, Computational biology, Biology, General Biochemistry, Genetics and Molecular Biology, Chemical Biology of the Cell, analyse métabolomique, 03 medical and health sciences, statistical analysis, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [INFO.INFO-DL]Computer Science [cs]/Digital Libraries [cs.DL], Use case, General Pharmacology, Toxicology and Pharmaceutics, signal processing, computer.programming_language, bioinformatics infrastructure, training, 030102 biochemistry & molecular biology, General Immunology and Microbiology, metabolomics, bioinformatics, distributed computing, cloud, business.industry, cloud computing, pipeline, Articles, General Medicine, Opinion Article, Data science, metabolomics, Open data, Identification (information), 030104 developmental biology, Workflow, multi-omics approaches, Elixir (programming language), [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], business, data standards, computer, Omics technologies
Abstract: We are grateful to the proteomics community for sharing their experiences from their meeting “The future of proteomics in ELIXIR” on March 1–2 2017 in Tübingen, allowing us to build on this and organise our workshop as a one-day event.The meeting was funded by PhenoMeNal, European Commission's Horizon2020 programme, grant agreement number 654241; Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for metabolomics within Europe, a workshop on the "Future of metabolomics in ELIXIR" was organised at Frankfurt Airport in Germany. This one-day strategic workshop involved representatives of ELIXIR Nodes, members of the PhenoMeNal consortium developing an e-infrastructure that supports workflow-based metabolomics analysis pipelines, and experts from the international metabolomics community. The workshop established metabolite identification as the critical area, where a maximal impact of computational metabolomics and data management on other fields could be achieved. In particular, the existing four ELIXIR Use Cases, where the metabolomics community - both industry and academia - would benefit most, and which could be exhaustively mapped onto the current five ELIXIR Platforms were discussed. This opinion article is a call for support for a new ELIXIR metabolomics Use Case, which aligns with and complements the existing and planned ELIXIR Platforms and Use Cases
Published: 2017

20. Residual perfluorocarbon liquid in human eyes

Author: ROMANO, MARIO, Vallejo Garcia JL, Castellani C, Costagliola C, Vinciguerra P., Romano, Mario, Vallejo Garcia, Jl, Castellani, C, Costagliola, C, and Vinciguerra, P.
Published: 2014

21. Pharmacological inhibition of the IGF-IR system in pituitary tumors in vitro

Author: Theodoropoulou, M, primary, Lisicki, D, additional, Monteserin Garcia, JL, additional, and Stalla, GK, additional
Published: 2014
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22. CP-100 Strategy for the simplification of antiretroviral therapy: protease inhibitor monotherapy

Author: Mañes, M, primary, Moriel, C, additional, Santaolalla, I, additional, Garcia, JL, additional, Martín, I, additional, and Segura, M, additional
Published: 2014
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23. PS-029 Review of the system for recording elderly patients’ medicines at admission

Author: Gasanz, I, primary, Rubio, B, additional, Corrales, L, additional, Crespo, P, additional, Garcia, JL, additional, and Segura, M, additional
Published: 2014
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24. Imatinib mesylate elicits positive clinical response in atypical chronic myeloid leukemia involving the platelet-derived growth factor receptor beta

Author: Garcia JL, Font de Mora J, Hernandez JM, Queizan JA, Gutierrez NC, and San Miguel JF
Published: 2003

25. Targeting the IGF-IR system in pituitary tumors in vitro: antiproliferative action & pitfalls

Author: Theodoropoulou, M, primary, Riebold, M, additional, Monteserin Garcia, JL, additional, and Stalla, GK, additional
Published: 2012
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26. Immunomodulation of angiogenic factor production in pituitary tumor cells under basal and hypoxia-mimicking conditions

Author: Lucia, K, primary, Scalfi, C, additional, Wu, Y, additional, Monteserin Garcia, JL, additional, Buchfelder, M, additional, Kuhlen, D, additional, Stalla, GK, additional, and Renner, U, additional
Published: 2012
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27. PHP37 - Análisis Del Modelo de Toma de Decisiones Sobre Cobertura de Medicamentos en Chile

Author: García, jL and Silva, NS
Published: 2015
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28. Atypical Chronic Myeloid Leukemia (aCML)

Author: Hernandez, JM, primary, Villaescusa, T, additional, Arefi, M, additional, López, L, additional, and Garcia, JL, additional
Published: 2011
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29. Factors associated with seropositivity for anti-Toxoplasma gondiiantibodies in pregnant women of Londrina, Paraná, Brazil

Author: Lopes, FMR, primary, Mitsuka-Breganó, R, additional, Gonçalves, DD, additional, Freire, RL, additional, Karigyo, CJT, additional, Wedy, GF, additional, Matsuo, T, additional, Reiche, EMV, additional, Morimoto, HK, additional, Capobiango, JD, additional, Inoue, IT, additional, Garcia, JL, additional, and Navarro, IT, additional
Published: 2009
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30. NOD proteins expression and function in the pituitary folliculostellate cells

Author: Corrêa-de-Santana, E, primary, Theodoropoulou, M, additional, Fröhlich, B, additional, Paez-Pereda, M, additional, Monteserin Garcia, JL, additional, Onofri, C, additional, Labeur, M, additional, Renner, U, additional, and Stalla, GK, additional
Published: 2008
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31. The Sirt1 activator resveratrol inhibits the mTOR-p70/S6K pathway

Author: Monteserin Garcia, JL, primary, Cerovac, V, additional, Stalla, GK, additional, and Theodoropoulou, M, additional
Published: 2008
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32. Octreotide restricts GH-secreting tumor growth by inhibiting mTOR

Author: Cerovac, V, primary, Monteserin Garcia, JL, additional, Stalla, GK, additional, and Theodoropoulou, M, additional
Published: 2008
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33. Methanobacterium oryzae sp. nov., a novel methanogenic rod isolated from a Philippines ricefield.

Author: Patel, Bharat Kumar., Patel, Bharat Kumar, Joulian, C., Ollivier, B., Garcia, JL., Roger, PA., Patel, Bharat Kumar., Patel, Bharat Kumar, Joulian, C., Ollivier, B., Garcia, JL., and Roger, PA.
Abstract: Yes.
Published: 2000

34. Calcitonin for metastatic bone pain

Author: Martinez, MJ, primary, Roqué, i Figuls M, additional, Alonso Coello, P, additional, Català, E, additional, Garcia, JL, additional, and Ferrandiz, M, additional
Published: 2003
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35. Dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats: role of the brain angiotensin system.

Author: Rodriguez-Perez AI, Valenzuela R, Villar-Cheda B, Guerra MJ, and Labandeira-Garcia JL
Published: 2012

36. Effects of short-term exercise and exercise training on cognitive function among patients with cardiac disease.

Author: Carles S Jr, Curnier D, Pathak A, Roncalli J, Bousquet M, Garcia JL, Galinier M, and Senard JM
Published: 2007
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37. Postnatal development of heart rate patterns elicited by an aversive CS and US in cats

Author: Nicholas T, Wilson Wj, Abraham P, George E. Wolfe, S. Stefan Soltysik, and Garcia Jl
Subjects: Male, Cultural Studies, Social Psychology, Ontogeny, Conditioning, Classical, Physiology, Alpha (ethology), Motor Activity, Developmental psychology, Heart Rate, Physical Stimulation, Heart rate, Animals, Applied Psychology, Electroshock, CATS, Communication, Age Factors, Classical conditioning, Philosophy, Animals, Newborn, Anthropology, Cats, Conditioning, Female, Psychology, Motor learning, Interbeat interval
Abstract: Heart rate and motor responses were recorded in cats of different ages during classical conditioning. A deceleratory-acceleratory heart rate pattern observed during the CS-US interval in one- and four-week-old kittens is an alpha conditioned response, a potentiated original response to the CS. At eight weeks of age two new distinct patterns of pure acceleration or pure deceleration are acquired during conditioning and in the absence of motor learning. At 12 weeks of age and in adult subjects, heart rate patterns during the CS-US interval become more complex and conditioned motor responses can be observed. A covariance of HR acceleration and motor responses during the CS-US interval is absent in eight-week-old subjects, but quite high in 12-week-old subjects and adult cats. The data are interpreted as suggesting separate elicitatory mechanisms of HR and motor responses which may show synchrony later in ontogeny.
Published: 1983

38. Chromosomal imbalances identified by comparative genomic hybridization in sporadic parathyroid adenomas

Author: Garcia, JL, Tardio, JC, Gutierrez, NC, Gonzalez, MB, Polo, Hernandez, JM, and Menarguez, J
Abstract: OBJECTIVE: To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). METHODS: Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH). RESULTS: The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains were found in all cases, and three cases (21%) also presented chromosomal losses. Genomic amplification was not observed. Chromosome 9 was involved in ten cases. Recurrent genetic gain was found on 9p22-24 and on 9q34, each in 6 of 14 cases (43%). Other recurrent gains included Xq26 in 6 PAs (43%) and 4q21-28 and 8p22-23, each in 4 of 14 cases (29%). Regions of recurrent genetic loss involved whole chromosome 11 and 20q12-13, each in 2 of 14 cases (14%). CONCLUSIONS: Our findings show chromosomal imbalances in all sporadic PAs studied by CGH, partly confirming previous reports, with the exception that we observed more chromosomal gains than losses. Several regions (9p22-24, 9q34, Xq26, 4q21-28, and 8p22-23) probably deserve further investigation in order to discard the presence of genes involved in parathyroid tumorigenesis.
Published: 2002

39. Nonlinear simulation techniques for the optimized design of push-push oscillators

Author: Ramirez, F., Garcia, Jl, Fernandez, T., Almudena Suarez, and Thal, H.

40. Responses of visual single cells in the superior colliculus of the albino rat to bright bars

Author: Francisco Gonzalez, Perez, R., Alonso, Jm, Labandeira-Garcia, Jl, and Acuna, C.

41. Polymorphism in the TNF promoter gene (-308A) correlates with worse response to infliximab in rheumatoid arthritis

Author: Pinto, Ja, Alejandro Mosquera, Freire, M., Rego, I., Lopez-Armada, Mj, Maneiro, E., Galdo, F., Fernandez-Garcia, Jl, and Blanco, Fj

42. DESCRIPTION AND EVOLUTIONARY RELATIONSHIPS OF 2 SPECIES OF THE DROSOPHILA-MULLERI CLUSTER (DIPTERA, DROSOPHILIDAE)

Author: Antonio Fontdevila, Wasserman, M., Pla, C., Pilares, L., Dearmengol, R., Suyo, Md, Sanchez, A., Vasquez, J., Ruiz, A., and Garcia, Jl

43. Rat brain cholinergic, dopaminergic, noradrenergic and serotonergic neurons express GABA(A) receptors derived from the alpha 3 subunit

Author: Jannette Rodriguez-Pallares, Caruncho, Hj, Lopez-Real, A., Wojcik, S., Guerra, Mj, and Labandeira-Garcia, Jl

44. Abnormalities on 1q are associated with a bad prognosis in sporadic Burkitt lymphoma. A cytogenetic and comparative genomic hybridization study

Author: Hernandez, Jm, Garcia, Jl, Lopez-Capitan, C., MJ Calasanz, Martinez-Climent, Ja, Gutierrez, Nc, Flores, T., Odero, Md, Piris, Ma, and San Miguel, Jf

45. Thermal transpiration of CO2 at high temperature

Author: Garcia, JL, primary, González de Prado, JE, additional, González Tejuca, L, additional, and Pajares, JA, additional
Published: 1975
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46. Troponina T cardiaca como nuevo marcador bioquímico en infarto agudo del miocardio y su relación con la CK MB.

Author: Garcia, Jl. Santos, Escamilla, Rm. Garcia, Garcia, Jn. Gutierrez, Caballero, A. Autrey, and Oliver, F. Sosa
Published: 1999

47. Case-based session: cardiac masses: Wednesday 3 December 2014, 11:00-12:30 * Location: Agora

Author: Aguiar Rosa, S, Moura Branco, L, Pinto Teixeira, P, Rio, P, Afonso Nogueira, M, Abreu, A, Ferreira, L, Jalles, N, Pinto, E, Cruz Ferreira, R, Cambronero Cortinas, E, Corbi Pascual, MJ, Sanchez Gallego, G, Cros Ruiz De Galarreta, T, Baxeiras Gonzalez, N, Fuentes Manso, R, Barambio Ruiz, M, Tercero Martinez, A, Barrionuevo Sanchez, MI, Rodriguez Garcia, JL, Yu, W-C, Hsu, C-Y, Huang, C-H, Wu, T-Y, Parato, V M, Bucari, S, Torracca, L, Placido, R, Silva Marques, J, Amaro, MJ, Mendes Pedro, M, Nobre E Menezes, M, Goncalves, S, Brito, D, Almeida, AG, Bochard Villanueva, B, Estornell Erill, J, Fabregat Andres, O, De La Espriella Juan, R, Chacon Hernandez, N, Garcia Gonzalez, P, Albiach-Montanana, C, Morell-Cabedo, S, Paya Serrano, R, and Ridocci Soriano, F
Abstract: 61 years-old caucasian man, with medical history of T-cell lymphoma diagnosed 3 years ago. He was treated with chemotherapy and immunotherapy, with no treatment for 16 months. He was admitted to the hospital because of sepsis with respiratory source. Transthoracic Echocardiogram (TTE) revealed normal left ventricular (LV) dimensions and preserved systolic function, without changes in segmental contractility. In LV, was observed a bulky and movable mass, occupying the apex and majority of cavity, with 63.7x39mm, heterogeneous, with no ventricular wall invasion. TTE did not show others significant alterations. Patient (ptt) underwent cardiac magnetic resonance (CMR) which confirmed the mass and suggested cardiac involvement by lymphoma. During this exam, the ptt became in respiratory arrest and focal neurologic signs appeared. After advanced life support, the TTE revealed that almost all mass disappeared. There was regression of neurologic signals, however ptt developed ischemic colitis and inferior limbs ischemia with severe rhabdomyolysis (creatine kinase 21516U/L). Computerized tomography revealed no encephalic lesions, however documented splenic, intestinal and aortic embolization. The diagnostic hypothesis was a cardiac involvement of a lymphoproliferative disorder or a thrombus with systemic embolization. The ptt underwent thromboembolectomy of the aortic bifurcation. The histological examination of the surgical piece identified an organized thrombus without evidence of neoplastic cells. The ptt was started on oral anticoagulation and glucocorticoids. The final diagnosis was thrombus due to a paraneoplastic prothrombotic state. This case illustrates a systemic and cardiac repercussion of a hematologic disease and an unusual complication of CMR. Figure Left ventricular mass
Published: 2014
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48. Thermal transpiration of CO 2 at high temperature

Author: Garcia, JL, González de Prado, JE, González Tejuca, L, and Pajares, JA
Published: 1975
Full Text: View/download PDF

49. Genomic landscape and immune-related gene expression profiling of epithelial ovarian cancer after neoadjuvant chemotherapy

Author: I. Lodewijk, A. Bernardini, C. Suárez-Cabrera, E. Bernal, R. Sánchez, J. L. Garcia, K. Rojas, L. Morales, S. Wang, X. Han, M. Dueñas, J. M. Paramio, L. Manso, Institut Català de la Salut, [Lodewijk I] Biomedical Research Institute I+12, University Hospital '12 de Octubre', Madrid, Spain. Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain. Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Bernardini A] Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Suárez-Cabrera C] Molecular Oncology Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain. Centro de Investigación Biomédica en Red Cáncer, Madrid, Spain. [Bernal E] Medical Oncology, University Hospital 12 De Octubre, Madrid, Spain. Medical Oncology, Infant Cristina University Hospital, Madrid, Spain. [Sánchez R] Medical Oncology, University Hospital 12 De Octubre, Madrid, Spain. [Garcia JL] Pathology Department, University Hospital 12 De Octubre, Madrid, Spain. [Rojas K] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Cancer Research, Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms [DISEASES], Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Genetic Phenomena::Gene Expression [PHENOMENA AND PROCESSES], Ovaris - Càncer - Tractament, neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas [ENFERMEDADES], Other subheadings::Other subheadings::/drug therapy [Other subheadings], Expressió gènica, Quimioteràpia combinada, Article, Therapeutics::Combined Modality Therapy::Neoadjuvant Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Oncology, Ovarian cancer, terapéutica::tratamiento combinado::tratamiento neoadyuvante [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], fenómenos genéticos::expresión génica [FENÓMENOS Y PROCESOS], RC254-282
Abstract: Ovarian cancer Càncer d'ovari Cáncer de ovario Platinum-based neoadjuvant chemotherapy followed by interval debulking surgery is an accepted treatment for patients with stage III or IV epithelial ovarian cancer who are not suitable for primary debulking surgery. The identification of suitable adjuvant treatments in these patients is an unmet need. Here, we explore potential genomic characteristics (mutational and immune-associated expression profiles) in a series of patients undergoing neoadjuvant chemotherapy. Tumor samples from biopsy and interval debulking surgery were analyzed for mutational landscape and immune profiling, together with detailed immunohistochemistry using different immune cell markers, and correlated with clinicopathological characteristics and potential response to neoadjuvant chemotherapy. No major differences in the mutational landscape were observed in paired biopsy and surgery samples. Genomic loss of heterozygosity was found to be higher in patients with total/near-total tumor response. The immune gene expression profile after neoadjuvant chemotherapy revealed activation of several immune regulation-related pathways in patients with no/minimal or partial response. In parallel, neoadjuvant therapy caused a significant increase of tumor-infiltrating lymphocyte population abundance, primarily due to an augmentation of the CD8+ T cell population. Remarkably, these changes occurred irrespective of potential homologous recombination defects, such as those associated with BRCA1/2 mutations. Our study strengthens the use of loss of heterozygosity as a biomarker of homologous repair deficiency. The changes of immune states during neoadjuvant chemotherapy reveal the dynamic nature of tumor-host immune interactions and suggest the potential use of immune checkpoint inhibitors or their combination with poly-ADP polymerase inhibitors in high stage and grade epithelial ovarian cancer patients undergoing neoadjuvant therapy. This study was funded by GlaxoSmithKline (GSK). I.L. position is funded by Fundación Científica Asociación Española Contra el Cáncer (AECC), Predoctoral AECC 2019 grant number PRDMA19024LODE. L. Morales position is funded by AECC, Postdoctoral AECC 2019 grant number POSTD19036MORA. This study was partially co-funded by European Regional Development Fund (FEDER) grants from Science and Innovation (SAF2015-66015-R and PID2019-110758RB-I00 to J.M.P.) and Instituto de Salud Carlos III (CIBERONC no. CB16/12/00228 to J.M.P.).
Published: 2021

50. Cardiovascular consequences of sleep disordered breathing: the role of CPAP treatment

Author: Salvatore Gallina, Maria R. Bonsignore, Luciano F. Drager, MA Martinez-Garcia, JL Pepin, M Cazzola, Bonsignore, Maria R., Gallina, Salvatore, and Drager, Luciano F.
Subjects: medicine.medical_specialty, business.industry, Internal medicine, randomized controlled trials, Sleep disordered breathing, Cardiology, blood pressure, Medicine, Cpap treatment, Settore MED/10 - Malattie Dell'Apparato Respiratorio, arrhythmia, business
Abstract: CPAP treatment decreases BP in OSA patients, especially in severe OSA, and in patients with poorly controlled BP. OSA adversely affects heart function and remodelling, but its role in the pathogenesis of HF remains unclear. Similarly, the impact of CPAP is uncertain, and results of the ongoing ADVENT-HF trial will provide more information. Several experimental studies in animals and humans indicate a central role of intermittent hypoxia in atherogenesis through multiple mechanisms. However, randomised controlled trials (RCTs) in patients with CAD and OSA found no difference in outcomes between CPAP-treated and untreated patients. The negative results of secondary prevention RCTs may be the result of exclusion of severely sleepy patients and poor compliance with CPAP treatment. In addition, room for improvement after substantial cardiac interventions may be very limited. Knowledge on arrhythmias in OSA has expanded in recent years, especially regarding AF and ventricular arrhythmias including sudden cardiac death. However, studies on the effects of CPAP are limited and controversial.
Published: 2020

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