156 results on '"Giacalone, Giacomo"'
Search Results
2. Cognitive, EEG, and MRI features of COVID-19 survivors: a 10-month study
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Cecchetti, Giordano, Agosta, Federica, Canu, Elisa, Basaia, Silvia, Barbieri, Alessandra, Cardamone, Rosalinda, Bernasconi, Maria Paola, Castelnovo, Veronica, Cividini, Camilla, Cursi, Marco, Vabanesi, Marco, Impellizzeri, Matteo, Lazzarin, Serena Marita, Fanelli, Giovanna Franca, Minicucci, Fabio, Giacalone, Giacomo, Falini, Andrea, Falautano, Monica, Rovere-Querini, Patrizia, Roveri, Luisa, and Filippi, Massimo
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- 2022
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3. Early seizures and risk of epilepsy and death after intracerebral haemorrhage: The MUCH Italy
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Pezzini, Alessandro, primary, Tarantino, Barbara, additional, Zedde, Marialuisa, additional, Marcheselli, Simona, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, DeLodovici, Maria Luisa, additional, Princiotta Cariddi, Lucia, additional, Vidale, Simone, additional, Paciaroni, Maurizio, additional, Azzini, Cristiano, additional, Padroni, Marina, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Del Sette, Massimo, additional, Tassi, Rossana, additional, De Franco, Ivo Giuseppe, additional, Cavallini, Anna, additional, Calabrò, Rocco Salvatore, additional, Cappellari, Manuel, additional, Giorli, Elisa, additional, Giacalone, Giacomo, additional, Lodigiani, Corrado, additional, Zenorini, Mara, additional, Valletta, Francesco, additional, Cutillo, Gianni, additional, Bonelli, Guido, additional, Abrignani, Giorgia, additional, Castellini, Paola, additional, Genovese, Antonio, additional, Latte, Lilia, additional, Trapasso, Maria Claudia, additional, Ferraro, Chiara, additional, Piancatelli, Francesco, additional, Pascarella, Rosario, additional, Grisendi, Ilaria, additional, Assenza, Federica, additional, Napoli, Manuela, additional, Moratti, Claudio, additional, Acampa, Maurizio, additional, and Grassi, Mario, additional
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- 2024
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4. Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy
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Pezzini, Alessandro, Tarantino, Barbara, Zedde, Maria Luisa, Marcheselli, Simona, Silvestrelli, Giorgio, Ciccone, Alfonso, Delodovici, Maria Luisa, Princiotta Cariddi, Lucia, Vidale, Simone, Paciaroni, Maurizio, Azzini, Cristiano, Padroni, Marina, Gamba, Massimo, Magoni, Mauro, Del Sette, Massimo, Tassi, Rossana, de Franco, Ivo Giuseppe, Cavallini, Anna, Calabrò, Rocco Salvatore, Cappellari, Manuel, Giorli, Elisa, Giacalone, Giacomo, Lodigiani, Corrado, Zenorini, Mara, Valletta, Francesco, Pascarella, Rosario, Abrignani, Giorgia, Castellini, Paola, Genovese, Antonio, Latte, Lilia, Trapasso, Maria Claudia, Grisendi, Ilaria, Assenza, Federica, Napoli, Manuela, Moratti, Claudio, Beccattini, Sofia, Acampa, Maurizio, Valzania, Franco, Grassi, Mario, and Gentilini, Davide
- Abstract
BackgroundWhether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.MethodsIn the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.Results1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).ConclusionsStatin use appears to be unrelated to the risk of ICH recurrence.
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- 2025
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5. Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease
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Gregori-Pla, Clara, Mesquita, Rickson C., Favilla, Christopher G., Busch, David R., Blanco, Igor, Zirak, Peyman, Frisk, Lisa Kobayashi, Avtzi, Stella, Maruccia, Federica, Giacalone, Giacomo, Cotta, Gianluca, Camps-Renom, Pol, Mullen, Michael T., Martí-Fàbregas, Joan, Prats-Sánchez, Luís, Martínez-Domeño, Alejandro, Kasner, Scott E., Greenberg, Joel H., Zhou, Chao, Edlow, Brian L., Putt, Mary E., Detre, John A., Yodh, Arjun G., Durduran, Turgut, and Delgado-Mederos, Raquel
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- 2021
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6. Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke
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Gregori-Pla, Clara, Blanco, Igor, Camps-Renom, Pol, Zirak, Peyman, Serra, Isabel, Cotta, Gianluca, Maruccia, Federica, Prats-Sánchez, Luís, Martínez-Domeño, Alejandro, Busch, David R., Giacalone, Giacomo, Martí-Fàbregas, Joan, Durduran, Turgut, and Delgado-Mederos, Raquel
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- 2019
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7. Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury
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Akhmedov, Alexander, Bonetti, Nicole R, Reiner, Martin F, Spescha, Remo D, Amstalden, Heidi, Merlini, Mario, Gaul, Daniel S, Diaz-Cañestro, Candela, Briand-Schumacher, Sylvie, Spescha, Rebecca S, Semerano, Aurora, Giacalone, Giacomo, Savarese, Gianluigi, Montecucco, Fabrizio, Kulic, Luka, Nitsch, Roger M, Matter, Christian M, Kullak-Ublick, Gerd A, Sessa, Maria, Lüscher, Thomas F, Beer, Jürg H, Liberale, Luca, and Camici, Giovanni G
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- 2019
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8. AP-1 (Activated Protein-1) Transcription Factor JunD Regulates Ischemia/Reperfusion Brain Damage via IL-1β (Interleukin-1β)
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Diaz-Cañestro, Candela, Reiner, Martin F., Bonetti, Nicole R., Liberale, Luca, Merlini, Mario, Wüst, Patricia, Amstalden, Heidi, Briand-Schumacher, Sylvie, Semerano, Aurora, Giacalone, Giacomo, Sessa, Maria, Beer, Jürg H., Akhmedov, Alexander, Lüscher, Thomas F., and Camici, Giovanni G.
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- 2019
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9. Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke
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Pfeiffer, Dorothea, Chen, Bowang, Schlicht, Kristina, Ginsbach, Philip, Abboud, Sherine, Bersano, Anna, Bevan, Steve, Brandt, Tobias, Caso, Valeria, Debette, Stéphanie, Erhart, Philipp, Freitag-Wolf, Sandra, Giacalone, Giacomo, Grau, Armin J., Hayani, Eyad, Jern, Christina, Jiménez-Conde, Jordi, Kloss, Manja, Krawczak, Michael, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lichy, Christoph, Maguire, Jane M., Martin, Juan J., Metso, Antti J., Metso, Tiina M., Mitchell, Braxton D., Pezzini, Alessandro, Rosand, Jonathan, Rost, Natalia S., Stenman, Martin, Tatlisumak, Turgut, Thijs, Vincent, Touzé, Emmanuel, Traenka, Christopher, Werner, Inge, Woo, Daniel, Del Zotto, Elisabetta, Engelter, Stefan T., Kittner, Steven J., Cole, John W., Grond-Ginsbach, Caspar, Lyrer, Philippe A., and Lindgren, Arne
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- 2019
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10. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection
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Debette, Stéphanie, Compter, Annette, Labeyrie, Marc-Antoine, Uyttenboogaart, Maarten, Metso, Tina M, Majersik, Jennifer J, Goeggel-Simonetti, Barbara, Engelter, Stefan T, Pezzini, Alessandro, Bijlenga, Philippe, Southerland, Andrew M, Naggara, Olivier, Béjot, Yannick, Cole, John W, Ducros, Anne, Giacalone, Giacomo, Schilling, Sabrina, Reiner, Peggy, Sarikaya, Hakan, Welleweerd, Janna C, Kappelle, L Jaap, de Borst, Gert Jan, Bonati, Leo H, Jung, Simon, Thijs, Vincent, Martin, Juan J, Brandt, Tobias, Grond-Ginsbach, Caspar, Kloss, Manja, Mizutani, Tohru, Minematsu, Kazuo, Meschia, James F, Pereira, Vitor M, Bersano, Anna, Touzé, Emmanuel, Lyrer, Philippe A, Leys, Didier, Chabriat, Hugues, Markus, Hugh S, Worrall, Bradford B, Chabrier, Stéphane, Baumgartner, Ralph, Stapf, Christian, Tatlisumak, Turgut, Arnold, Marcel, and Bousser, Marie-Germaine
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- 2015
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11. Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults
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Poli, L., Zedde, M., Zini, A., Del Sette, M., Lodigiani, C., Spalloni, A., Di Lisi, F., Toriello, A., Piras, V., Stilo, C., Tomelleri, G., Tancredi, L., Paciaroni, M., Silvestrelli, G., Adami, A., Costa, P., Morotti, A., De Giuli, V., Caria, F., Gamba, M., Malferrari, G., Simone, A. M., Musolino, R., Giorli, E., Banfi, E., Marcheselli, S., Rasura, M., Pugliese, N., Melis, M., Bovi, P., Padovani, A., Burlina, A., Pezzini, A., Del Zotto, Elisabetta, Giossi, Alessia, Sessa, Maria, Gilberti, Nicola, Magoni, Mauro, Ferrazzi, Paola, Librè, Luca, Rota, Lidia Luciana, Patella, Rosalba, Di Liso, Filomena, Calabrò, Rocco Salvatore, Bramanti, Placido, La Spina, Paolo, Finocchi, Cinzia, Balestrino, Maurizio, Bruno, Chiara, Massucco, Davide, Gandolfo, Carlo, Traverso, Elisabetta, DeLodovici, Maria Luisa, Verrengia, Elena Pinuccia, Carimati, Federico, Bono, Giorgio, DellʼAcqua, Maria Luisa, Bigliardi, Guido, Vandelli, Laura, Nichelli, Paolo Frigio, Carletti, Monica, Cerrato, Paolo, Iacoviello, Licia, Di Castelnuovo, Augusto, de Gaetano, Giovanni, Grassi, Mario, Locatelli, Giampiero, Caso, Valeria, DʼAmore, Cataldo, Agnelli, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Arnaboldi, Marco, Giacalone, Giacomo, Zanoli, Elisa, Cavallini, Anna, Persico, Alessandra, Micieli, Giuseppe, Chiti, Alberto, Orlandi, Giovanni, Marchi, Piernicola, Lanari, Alessia, Ciccone, Alfonso, Cucurachi, Laura, Bonifati, Marco Domenico, and Marcello, Norina
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- 2017
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12. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study
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Paciaroni, Maurizio, Inzitari, Domenico, Agnelli, Giancarlo, Caso, Valeria, Balucani, Clotilde, Grotta, James C., Sarraj, Amrou, Sung-Il, Sohn, Chamorro, Angel, Urra, Xabier, Leys, Didier, Henon, Hilde, Cordonnier, Charlotte, Dequatre, Nelly, Aguettaz, Pierre, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Zini, Andrea, Vallone, Stefano, Dell’Acqua, Maria Luisa, Menetti, Federico, Nencini, Patrizia, Mangiafico, Salvatore, Barlinn, Kristian, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Bovi, Paolo, Cappellari, Manuel, Linfante, Italo, Dabus, Guilherme, Marcheselli, Simona, Pezzini, Alessandro, Padovani, Alessandro, Alexandrov, Andrei V., Shahripour, Reza Bavarsad, Sessa, Maria, Giacalone, Giacomo, Silvestrelli, Giorgio, Lanari, Alessia, Ciccone, Alfonso, De Vito, Alessandro, Azzini, Cristiano, Saletti, Andrea, Fainardi, Enrico, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Silvestrini, Mauro, Ferrarese, Carlo, Beretta, Simone, Tassi, Rossana, Martini, Giuseppe, Tsivgoulis, Georgios, Vasdekis, Spyros N., Consoli, Domenico, Baldi, Antonio, D’Anna, Sebastiano, Luda, Emilio, Varbella, Ferdinando, Galletti, Giampiero, Invernizzi, Paolo, Donati, Edoardo, De Lodovici, Maria Luisa, Bono, Giorgio, Corea, Francesco, Sette, Massimo Del, Monaco, Serena, Riva, Maurizio, Tassinari, Tiziana, Scoditti, Umberto, and Toni, Danilo
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- 2015
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13. Cognitive, EEG and MRI features of COVID-19 survivors: a 10-month study (P1-1.Virtual)
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Cecchetti, Giordano, primary, Agosta, Federica, additional, Canu, Elisa, additional, Basaia, Silvia, additional, Barbieri, Alessandra, additional, Cardamone, Rosalinda, additional, Bernasconi, Maria Paola, additional, Castelnovo, Veronica, additional, Cividini, Camilla, additional, Cursi, Marco, additional, Vabanesi, Marco, additional, Impellizzeri, Matteo, additional, Lazzarin, Serena Marita, additional, Fanelli, Giovanna Franca, additional, Minicucci, Fabio, additional, Giacalone, Giacomo, additional, Falini, Andrea, additional, Falautano, Monica, additional, Rovere-Querini, Patrizia, additional, Roveri, Luisa, additional, and Filippi, Massimo, additional
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- 2022
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14. MGAT5 and disease severity in progressive multiple sclerosis
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Esposito, Federica, Wojcik, Jerome, Rodegher, Mariaemma, Radaelli, Marta, Moiola, Lucia, Ghezzi, Angelo, Capra, Ruggero, Brambilla, Paola, Sorosina, Melissa, Giacalone, Giacomo, Martinelli, Vittorio, Comi, Giancarlo, Abderrahim, Hadi, and Boneschi, Filippo Martinelli
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- 2011
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15. Prospective eeg cortical sources and connectivity evaluation in patients with recent COVID-19 and cognitive disturbances: An eLORETA study
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Cecchetti, Giordano, Agosta, Federica, Vabanesi, Marco, Canu, Elisa, Fanelli, Giovanna, Barbieri, Alessandra, Bernasconi, Maria Paola, Lazzarin, Serena, Impellizzeri, Matteo, Giacalone, Giacomo, Falautano, Monica, Querini, Patrizia Rovere, Minicucci, Fabio, Roveri, Luisa, and Filippi, Massimo
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- 2021
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16. Cognitive and behaviorial features of a cohort of patients in COVID-19 post-acute phase
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Canu, Elisa, Agosta, Federica, Barbieri, Alessandra, Bernasconi, Maria Paola, Cecchetti, Giordano, Vabanesi, Marco, Castelnovo, Veronica, Giacalone, Giacomo, Falautano, Monica, Querini, Patrizia Rovere, Roveri, Luisa, and Filippi, Massimo
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- 2021
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17. Defining Minor Symptoms in Acute Ischemic Stroke
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Strambo, Davide, Zambon, Alberto A., Roveri, Luisa, Giacalone, Giacomo, Di Maggio, Giovanni, Peruzzotti-Jametti, Luca, La Gioia, Sara, Galantucci, Sebastiano, Comi, Giancarlo, and Sessa, Maria
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- 2015
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18. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K., van der Spek, Rick A.A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L.M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Martinsen, Amy E, Aamodt, Anne Hege, Skogholt, Anne Heidi, Sandset, Else Charlotte, Kristoffersen, Espen S, Ellekjaer, Hanne, Heuch, Ingrid, Nielsen, Jonas Bille, Hagen, Knut, Fritsche, Lars, Thomas, Laurent F., Pedersen, Linda, Gabrielsen, Maiken E, Vigeland, Maria Dehli, Holmen, Oddgeir, Zhou, Wei, Chen, Junshi, Chen (PI), Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI), Liming, Liu, Depei, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gan, Wei, Gilbert, Simon, Hacker, Alex, Hill, Michael, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt-Valle, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zou, Mingyuan, Yan, Shichun, Zhou, Xue, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Hua, Yujie, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin Sisi Wang, Yulu, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhou, Ding Zhang, Zhou, Gang, Feng, Shixian, Chang, Ling, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Gong, Weiwei, Wang, Meng, Xie, Kaixu, Chen, Lingli, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Zhang, Libo, Nagai, Akiko, Muto, Kaori, Hirata, Makoto, Morisaki, Takayuki, Yamashita, Yasushi, Kamatani, Yoichiro, Kambara, Yoko, Murakami, Yoshinori, Masumoto, Akihide, Nagayama, Satoshi, Miki, Yoshio, Yoshimori, Kozo, Fujioka, Tomoaki, Takata, Ryo, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Minami, Shiro, Yamaguchi, Hiroki, Koretsune, Yukihiro, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Suzuki, Takao, Sinozaki, Nobuaki, Murayama, Shigeo, Furukawa, Yoichi, Yamanashi, Yuji, Papagiannaki, Chrisanthi, Piotin, Michel, Trystram, Denis, Edjlali-Goujon, Myriam, Boulouis, Grégoire, Rodriguez, Christine, Hassen, Waghi Ben, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Levrier, Olivier, Aguettaz, Pierre, Combaz, Xavier, Pasco, Anne, l’Allinec, Vincent, Bintner, Marc, Molho, Marc, Pascale, Gauthier, Chivot, Cyril, Costalat, Vincent, Darganzil, Cyril, Bonafé, Alain, Januel, Anne Christine, Michelozzi, Caterina, Cognard, Christophe, Bonneville, Fabrice, Tall, Philippe, Darcourt, Jean, Biondi, Alessandra, Iosif, Cristina, Ferre, Jean Christophe, Gauvrit, Jean Yves, Eugene, François, Raoult, Hélène, Gentric, Jean Christophe, Ognard, Julien, Anxionnat, René, Gory, Benjamin, Bracard, Serge, Derelle, Anne Laure, Tonnelet, Romain, Spelle, Laurent, Ikka, Léon, Ozanne, Augustin, Gallas, Sophie, Caroff, Jildaz, Achour, Nidal Ben, Moret, Jacques, Chabert, Emmanuel, Berge, Jérôme, Marnat, Gaultier, Barreau, Xavier, Gariel, Florent, Clarencon, Frédéric, Aggour, Mohammed, Ricolfi, Frédéric, Chavent, Adrien, Thouant, Pierre, Lebidinsky, Pablo, Lemogne, Brivael, Herbreteau, Denis, Bibi, Richard, Janot, Kevin, Pierot, Laurent, Soize, Sébastien, Labeyrie, Marc Antoine, Vandendries, Christophe, Kazemi, Appoline, Leclerc, Xavier, Pruvo, Jean Pierre, Bricout, Nicolas, Velasco, Stéphane, Boucebci, Samy, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vuillier, Fabrice, Tzourio, Christophe, Santos, Michael Dos, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Muiesan, Maria Lorenza, Salvetti, Massimo, Rosei, Enrico Agabiti, Lanfranconi, Silvia, Baron, Pierluigi, Ferrarese, Carlo, Susani, Emanuela, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Guadagni, Fiorella, Paciaroni, Maurizio, Ballabio, Elena, Parati, Eugenio A., Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Altintas, Ayse, Martin, Juan José, Kittner, Steven, Mitchell, Braxton, Stine, Colin, O’Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J., de Lau, Lonneke M.L., Hofman, Albert, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Werring, David, Alg, Varinder, Hostettler, Isabel, Bonner, Stephen, Walsh, Daniel, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Roberts, Gareth, Jones, Timothy, Critchley, Giles, Sharma, Pankaj, Nelson, Richard, Whitfield, Peter, Ross, Stuart, Patel, Hiren, Eldridge, Paul, Saastamoinen, Kari, Patel, Umang, Lawrance, Enas, Vandabona, Subha, Mendelow, David, Teal, Rachel, Warner, Orlando, Kirkpatrick, Peter, Seshadri, Sudha, Kilarski, Laura, Hyacinth, Hyacinth I, Oliveira, Jamary, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Norrving, Bo, Smith, Gustav, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Bang, Oh Young, Chung, Jong-Won, Kim, Gyeong-Moon, Zhuang, Qishuai, Sheu, Wayne, Smalley, June, Howson, Joanna, Granata, Alessandra, Markus, Hugh, Wardlaw, Joanna, Cole, John, Thalamuthu, Anbupalam, Hopewell, Jemma, Worrall, Bradford, Bis, Josh, Tirschwell, David, Reiner, Alex, Dhar, Raj, Lee, Jin-Moo, Mortenson, Janne, Wassertheil-Smoller, Sylvia, Prasad, Kameshwar, Fisher, Mark, Traenka, Christopher, Wang, Xingwu, Wang, Yongjun, Rouanet, Francois, Sibon, Igor, Sarnowski, Chloé, Maillard, Pauline, Aparicio, Hugo Javier, Dupuis, Josee, Yang, Qiong, Luvizutto, Gustavo, Chasman, Daniel, Rexrode, Kathryn, Harriot, Andrea, Phuah, Chia-Ling, Santo, Gustavo, Gerard, Jen, Liu, Guiyou, Aaron, Sanjith, Christudass, Christhunesa S., Salomi, BSB, Sanghera, Dharambir, Boehme, Amelia, Elkind, Mitchell, Gretarsdottir, Solveig, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Goldstein, Larry, Waddy, Salina, Vojinovic, Dina, Ikram, Arfan, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Kooperberg, Charles, Abboud, Sherrine, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Happola, Olli, Strbian, Daniel, Tomppo, Liisa, Pathak, Abhishek, Pfeiffer, Dorothea, Aires, de Buenos, de Carvalho, Joao Jose Freitas, Ribeiro, Priscila, Torres, Nuria, Barboza, Miguel, Plomaritoglou, Androniki, Bjorkegren, Johan, Chan, Yu-Feng Yvonne, Gudnason, Villi, Jimenez-Conde, Jordi, Soriano, Carolina, Roquer, Jaume, Bentley, Paul, Tournier-Lasserve, Elisabeth, Dufouil, Carole, Debette, Stephanie, Mishra, Aniket, Wee, Lawrence, Siddiqi, Saima, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Arauz, Antonio, Korostynski, Michal, Launer, Lenore, Yue, Suo, bersano, anna, Juchniewicz, Karol Józef, Mateusz, Adamski, Pera, Joanna, Wnuk, Marcin, Levi, Christopher, Gusdon, Aaron, Kostulas, Konstantinos, Maxwell, Jessye, Duering, Marco, Jagiella, Jeremiasz, Hata, Jun, Ninomiya, Toshiharu, Nguyen, Vinh, Thorarinsson, Bjorn Logi, Lee, Tsong-Hai, Rakitko, Alexandr, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Stenman, Martin, Ilinca, Andreea, Staals, Julie, Sadr-Nabavi, Ariane, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Romero, Javier, Cramer, Steve, Golland, Polina, Mueller, Bertram, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, mansour, Ossama yassin, Karaszewski, Bartosz, Enzinger, Christian, Schmidt, Reinhold, Seiler, Stephan, Pichler, Alexander, Ovbiagele, Bruce, Yamada, Yoshiji, Rundek, Tatjana, Blanton, Susan, P, John, Chern, Joseph, O'Donnell, Chris, Corriveau, Roderick, Bhattacharya, Pallab, Gwinn, Katrina, CHANDRA, BHARATENDU, Chen, Christopher, Kalaria, Raj, Koenig, Jim, Singh, Om Prakash, Olugbodi, Akintomi, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Olesen, Jes, Kubo, Michiaki, Spence, David, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Braga, Gabriel, Xu, Huichun, Assimes, Tim, Raskurazhev, Anton, Lee, Wei Ling, Burri, Philippe, Frid, Petrea, GmbH, Heilbronn, Deng, Zhen, Habibi-koolaee, Mahdi, Vijayan, Murali, Leung, Thomas, Wong, Lawrence, Mok, Vincent, Choy, Richard, Jern, Christina, Lebedeva, Elena, Farrall, Martin, Jiayuan, Xu, Loo, Keat Wei, Rinkel, Gabriel, Magnus, Rudolf, Goncalves, Anderson, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Kim, Helen, Rolfs, Arndt, Owolabi, Mayowa, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., Algra, Ale, van der Laan, Sander W., Macleod, Mary, Howard, George, Tiwari, Hemant, Irvin, Ryan, Albright, Karen C., Perry, Rodney, Kidwell, Chelsea, Pavlovic, Aleksandra, Sargurupremraj, Murali, Schilling, Sabrina, Pezzini, Alessandro, Abd-Allah, Foad, DeCarli, Charles, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Larsson, Susanna C., Rutten, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Kissela, Brett, Ibenez, Laura Garcia, Salman, Rustam, Sudlow, Cathie, McDonough, Caitrin Wheeler, Silliman, Scott, Magvanjav, Oyunbileg, van Agtmael, Tom, Walters, Matthew, Lorentzen, Erik, Stanne, Tara, Olsson, Martina, Nakagawa, Kazuma, Akinyemi, Rufus, Cotlatciuc, Ioana, O'Connell, Jeff, Sparks, Mary, Sorkin, John, Dave, Tushar, Naylor, Jill, Brown, Devin, Du, Rose, Kulik, Tobias B., Attia, John, Faber, James E, Rothwell, Peter, Márquez, Elsa Valdés, Mancuso, Michelangelo, Souza, Doralina Brum, de Silva, Ranil, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Illoh, Kachikwu, Milewicz, Dianna, Majersik, Jennifer, DeHavenon, Adam, Kalani, Yashar, Alexander, Matthew, Cushman, Mary, Sale, Michele, Owens, Debra, Keene, Keith, Rich, Stephe, Psaty, Bruce, Longstreth, Will, Atadzhanov, Masharip, Wolfe, Stacey Quintero, Langefeld, Carl, Bushnell, Cheryl, Cruchaga, Carlos, Konrad, Jan, Liu, Junfeng, Sheth, Kevin, Falcone, Guido, Donahue J, Kathleen, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Coleman, Jonathan R.I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J.M., Sargurupremraj, Muralidharan, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J.E., Worrall, Bradford B., Slowik, Agnieszka, Gaál-Paavola, Emilia I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Redon, Richard, Veldink, Jan H., Ruigrok, Ynte M., Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, investigators, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study, (ISGC), International Stroke Genetics Consortium, Morel, Sandrine, and Bijlenga, Philippe Alexandre Pierre
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genetics [Blood Pressure] ,Medizin ,Genome-wide association study ,Blood Pressure ,Disease ,ddc:616.07 ,Bioinformatics ,616: Innere Medizin und Krankheiten ,0302 clinical medicine ,Risk Factors ,physiopathology [Hypertension] ,genetics [Genetic Predisposition to Disease] ,Genetic risk factor ,Stroke ,0303 health sciences ,Smoking ,genetics [Smoking] ,genetics [Intracranial Aneurysm] ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,Cerebrovascular disorder ,3. Good health ,genetics [European Continental Ancestry Group] ,Hypertension ,genetics [Polymorphism, Single Nucleotide] ,Subarachnoid hemorrhage ,pathology [Intracranial Aneurysm] ,genetics [White People] ,Biology ,Genetic correlation ,pathology [Endothelial Cells] ,Polymorphism, Single Nucleotide ,Article ,White People ,03 medical and health sciences ,Aneurysm ,Asian People ,ddc:570 ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,cardiovascular diseases ,030304 developmental biology ,genetics [Subarachnoid Hemorrhage] ,genetics [Asian Continental Ancestry Group] ,572: Biochemie ,genetics [Asian People] ,pathology [Subarachnoid Hemorrhage] ,adverse effects [Smoking] ,Endothelial Cells ,Subarachnoid Hemorrhage ,medicine.disease ,Intracranial aneurysm ,Genetic architecture ,ddc:616.8 ,Case-Control Studies ,genetics [Hypertension] ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
An author correction to this article published in December 2020 is available at https://doi.org/10.1038/s41588-020-00760-4. Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.
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- 2021
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19. Additional file 1 of Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease
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Gregori-Pla, Clara, Rickson C. Mesquita, Favilla, Christopher G., Busch, David R., Blanco, Igor, Zirak, Peyman, Frisk, Lisa Kobayashi, Avtzi, Stella, Maruccia, Federica, Giacalone, Giacomo, Cotta, Gianluca, Camps-Renom, Pol, Mullen, Michael T., Martí-Fàbregas, Joan, Prats-Sánchez, Luís, Martínez-Domeño, Alejandro, Kasner, Scott E., Greenberg, Joel H., Zhou, Chao, Edlow, Brian L., Putt, Mary E., Detre, John A., Yodh, Arjun G., Durduran, Turgut, and Delgado-Mederos, Raquel
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Data_FILES - Abstract
Additional file 1.
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- 2021
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20. TNF‐α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm‐ageing
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Liberale, Luca, primary, Bonetti, Nicole R., additional, Puspitasari, Yustina M., additional, Vukolic, Ana, additional, Akhmedov, Alexander, additional, Diaz‐Cañestro, Candela, additional, Keller, Stephan, additional, Montecucco, Fabrizio, additional, Merlini, Mario, additional, Semerano, Aurora, additional, Giacalone, Giacomo, additional, Bacigaluppi, Marco, additional, Sessa, Maria, additional, Ruschitzka, Frank, additional, Lüscher, Thomas F., additional, Libby, Peter, additional, Beer, Jürg H., additional, and Camici, Giovanni G., additional
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- 2021
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21. Cognitive and Behaviorial Features of COVID-19 Patients in Post-Acute Phase (2688)
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Canu, Elisa, primary, Agosta, Federica, additional, Barbieri, Alessandra, additional, Bernasconi, Maria Paola, additional, Cecchetti, Giordano, additional, Vabanesi, Marco, additional, Castelnovo, Veronica, additional, Giacalone, Giacomo, additional, Falautano, Monica, additional, Rovere-Querini, Patrizia, additional, Roveri, Luisa, additional, and Filippi, Massimo, additional
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- 2021
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22. Time-Domain Near-Infrared Spectroscopy in Subjects with Asymptomatic Cerebral Small Vessel Disease
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Giacalone, Giacomo, primary, Zanoletti, Marta, additional, Re, Rebecca, additional, Contini, Davide, additional, Spinelli, Lorenzo, additional, Torricelli, Alessandro, additional, and Roveri, Luisa, additional
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- 2021
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23. Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study
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De Lorenzo, Rebecca, primary, Conte, Caterina, additional, Lanzani, Chiara, additional, Benedetti, Francesco, additional, Roveri, Luisa, additional, Mazza, Mario G., additional, Brioni, Elena, additional, Giacalone, Giacomo, additional, Canti, Valentina, additional, Sofia, Valentina, additional, D’Amico, Marta, additional, Di Napoli, Davide, additional, Ambrosio, Alberto, additional, Scarpellini, Paolo, additional, Castagna, Antonella, additional, Landoni, Giovanni, additional, Zangrillo, Alberto, additional, Bosi, Emanuele, additional, Tresoldi, Moreno, additional, Ciceri, Fabio, additional, and Rovere-Querini, Patrizia, additional
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- 2020
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24. Time-Resolved NIRS: a Clinical Study on Ischemic Stroke Patients
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Zanoletti, Marta, primary, Giacalone, Giacomo, additional, Contini, Davide, additional, Re, Rebecca, additional, Spinelli, Lorenzo, additional, Germinario, Bruno, additional, Roveri, Luisa, additional, and Torricelli, Alessandro, additional
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- 2020
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25. Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors
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Martinelli-Boneschi, Filippo, Giacalone, Giacomo, Magnani, Giuseppe, Biella, Gloria, Coppi, Elisabetta, Santangelo, Roberto, Brambilla, Paola, Esposito, Federica, Lupoli, Sara, Clerici, Francesca, Benussi, Luisa, Ghidoni, Roberta, Galimberti, Daniela, Squitti, Rosanna, Confaloni, Annamaria, Bruno, Giuseppe, Pichler, Sabrina, Mayhaus, Manuel, Riemenschneider, Matthias, Mariani, Claudio, Comi, Giancarlo, Scarpini, Elio, Binetti, Giuliano, Forloni, Gianluigi, Franceschi, Massimo, and Albani, Diego
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- 2013
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26. Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood–brain barrier integrity: a translational study
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Liberale, Luca, primary, Gaul, Daniel S, additional, Akhmedov, Alexander, additional, Bonetti, Nicole R, additional, Nageswaran, Vanasa, additional, Costantino, Sarah, additional, Pahla, Jürgen, additional, Weber, Julien, additional, Fehr, Vera, additional, Vdovenko, Daria, additional, Semerano, Aurora, additional, Giacalone, Giacomo, additional, Kullak-Ublick, Gerd A, additional, Sessa, Maria, additional, Eriksson, Urs, additional, Paneni, Francesco, additional, Ruschitzka, Frank, additional, Montecucco, Fabrizio, additional, Beer, Jürg H, additional, Lüscher, Thomas F, additional, Matter, Christian M, additional, and Camici, Giovanni G, additional
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- 2019
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27. Time-resolved near infrared spectroscopy in ischemic stroke patients
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Zanoletti, Marta, primary, Giacalone, Giacomo, additional, Contini, Davide, additional, Re, Rebecca, additional, Spinelli, Lorenzo, additional, Germinario, Bruno Nicolò, additional, Roveri, Luisa, additional, and Torricelli, Alessandro, additional
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- 2019
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28. Optical Properties and Oximetry Parameters of Cerebral Atrophic and Normal Regions in Healthy Volunteers (P5.1-018)
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Roveri, Luisa, primary, Zanoletti, Marta, additional, Re, Rebecca, additional, Contini, Davide, additional, Spinelli, Lorenzo, additional, Torricelli, Alessandro, additional, and Giacalone, Giacomo, additional
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- 2019
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29. Time-Domain Near Infrared Spectroscopy in Acute Ischemic Stroke Patients with Different Sites of Large Vessel Occlusion. (P1.3-052)
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Giacalone, Giacomo, primary, Zanoletti, Marta, additional, Re, Rebecca, additional, Germinario, Bruno, additional, Contini, Davide, additional, Spinelli, Lorenzo, additional, Torricelli, Alessandro, additional, and Roveri, Luisa, additional
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- 2019
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30. Cerebral Oximetry in Acute Ischemic Stroke Patients According to Brain Area and Recanalization Status (P2.3-050)
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Giacalone, Giacomo, primary, Zanoletti, Marta, additional, Re, Rebecca, additional, Contini, Davide, additional, Spinelli, Lorenzo, additional, Torricelli, Alessandro, additional, and Roveri, Luisa, additional
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- 2019
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31. Abstract TP81: Time-Domain Near-Infrared Spectroscopy in Acute Ischemic Stroke Patients
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Giacalone, Giacomo, primary, Zanoletti, Marta, additional, Re, Rebecca, additional, Germinario, Bruno, additional, Contini, Davide, additional, Spinelli, Lorenzo, additional, Torricelli, Alessandro, additional, and Roveri, Luisa, additional
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- 2019
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32. Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood–brain barrier integrity: a translational study.
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Liberale, Luca, Gaul, Daniel S, Akhmedov, Alexander, Bonetti, Nicole R, Nageswaran, Vanasa, Costantino, Sarah, Pahla, Jürgen, Weber, Julien, Fehr, Vera, Vdovenko, Daria, Semerano, Aurora, Giacalone, Giacomo, Kullak-Ublick, Gerd A, Sessa, Maria, Eriksson, Urs, Paneni, Francesco, Ruschitzka, Frank, Montecucco, Fabrizio, Beer, Jürg H, and Lüscher, Thomas F
- Abstract
Aims Aging is an established risk factor for stroke; genes regulating longevity are implicated in the pathogenesis of ischaemic stroke where to date, therapeutic options remain limited. The blood–brain barrier (BBB) is crucially involved in ischaemia/reperfusion (I/R) brain injury thus representing an attractive target for developing novel therapeutic agents. Given the role of endothelial cells in the BBB, we hypothesized that the endothelial-specific expression of the recently described longevity gene SIRT6 may exhibit protective properties in stroke. Methods and results SIRT6 endothelial expression was reduced following stroke. Endothelial-specific Sirt6 knockout (eSirt6
−/− ) mice, as well as animals in which Sirt6 overexpression was post-ischaemically induced, underwent transient middle cerebral artery occlusion (tMCAO). eSirt6−/− animals displayed increased infarct volumes, mortality, and neurological deficit after tMCAO, as compared to control littermates. Conversely, post-ischaemic Sirt6 overexpression decreased infarct size and neurological deficit. Analysis of ischaemic brain sections revealed increased BBB damage and endothelial expression of cleaved caspase-3 in eSIRT6−/− mice as compared to controls. In primary human brain microvascular endothelial cells (HBMVECs), hypoxia/reoxygenation (H/R) reduced SIRT6 expression and SIRT6 silencing impaired the barrier function (transendothelial resistance) similar to what was observed in mice exposed to I/R. Further, SIRT6 -silenced HBMVECs exposed to H/R showed reduced viability, increased cleaved caspase-3 expression and reduced activation of the survival pathway Akt. In ischaemic stroke patients, SIRT6 expression was higher in those with short-term neurological improvement as assessed by NIHSS scale and correlated with stroke outcome. Conclusion Endothelial SIRT6 exerts a protective role in ischaemic stroke by blunting I/R-mediated BBB damage and thus, it may represent an interesting novel therapeutic target to be explored in future clinical investigation. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR]- Published
- 2020
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33. Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury
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Akhmedov, Alexander, primary, Bonetti, Nicole R, additional, Reiner, Martin F, additional, Spescha, Remo D, additional, Amstalden, Heidi, additional, Merlini, Mario, additional, Gaul, Daniel S, additional, Diaz-Cañestro, Candela, additional, Briand-Schumacher, Sylvie, additional, Spescha, Rebecca S, additional, Semerano, Aurora, additional, Giacalone, Giacomo, additional, Savarese, Gianluigi, additional, Montecucco, Fabrizio, additional, Kulic, Luka, additional, Nitsch, Roger M, additional, Matter, Christian M, additional, Kullak-Ublick, Gerd A, additional, Sessa, Maria, additional, Lüscher, Thomas F, additional, Beer, Jürg H, additional, Liberale, Luca, additional, and Camici, Giovanni G, additional
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- 2018
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34. Microvascular Cerebral Blood Flow Fluctuations Due to Periodic Apneas in Acute Ischemic Stroke
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Gregori Pla, Clara, primary, Avtzi, Stella, additional, Cotta, Gianluca, additional, Giacalone, Giacomo, additional, Maruccia, Federica, additional, Camps-Renom, Pol, additional, Martí-Fàbregas, Joan, additional, Delgado-Mederos, Raquel, additional, Mayos, Mercedes, additional, and Durduran, Turgut, additional
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- 2018
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35. Genetic imbalance in patients with cervical artery dissection
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Grond-Ginsbach, Caspar, Brandt, Tobias, Caso, Valeria, Debette, Stéphanie, Dichgans, Martin, Geschwendtner, Andreas, Giacalone, Giacomo, Martin, Juan José Acebes J.J., Metso, Antti, Metso, Tiina, Grau, Armin A.J., Chen, Bowang, Kloss, Manja, Lichy, Christoph, Pezzini, Alessandro, Traenka, Christopher, Schreiber, Stefan, Thijs, Vincent, Touzé, Emmanuel, del Zotto, Elisabetta, Tatlisumak, Turgut, Leys, Didier, Krawczak, Michael, Lyrer, Philippe, Engelter, Stefan, Pjontek, Rastislav, Ginsbach, Philip, Jiang, Yanxiang, Abboud, Sherine, Arnold, Marie Luise, Bersano, Anna, Grond-Ginsbach, Caspar, Brandt, Tobias, Caso, Valeria, Debette, Stéphanie, Dichgans, Martin, Geschwendtner, Andreas, Giacalone, Giacomo, Martin, Juan José Acebes J.J., Metso, Antti, Metso, Tiina, Grau, Armin A.J., Chen, Bowang, Kloss, Manja, Lichy, Christoph, Pezzini, Alessandro, Traenka, Christopher, Schreiber, Stefan, Thijs, Vincent, Touzé, Emmanuel, del Zotto, Elisabetta, Tatlisumak, Turgut, Leys, Didier, Krawczak, Michael, Lyrer, Philippe, Engelter, Stefan, Pjontek, Rastislav, Ginsbach, Philip, Jiang, Yanxiang, Abboud, Sherine, Arnold, Marie Luise, and Bersano, Anna
- Abstract
Background: Genetic and environmental risk factors are assumed to contribute to the susceptibility to cervical artery dissection (CeAD). To explore the role of genetic imbalance in the etiology of CeAD, copy number variants (CNVs) were identified in high-density microarrays samples from the multicenter CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) study and from control subjects from the CADISP study and the German PopGen biobank. Microarray data from 833 CeAD patients and 2040 control subjects (565 subjects with ischemic stroke due to causes different from CeAD and 1475 disease-free individuals) were analyzed. Rare genic CNVs were equally frequent in CeAD-patients (16.4%; n=137) and in control subjects (17.0%; n=346) but differed with respect to their genetic content. Compared to control subjects, CNVs from CeAD patients were enriched for genes associated with muscle organ development and cell differentiation, which suggests a possible association with arterial development. CNVs affecting cardiovascular system development were more common in CeAD patients than in control subjects (p=0.003; odds ratio (OR) =2.5; 95% confidence interval (95% CI) =1.4-4.5) and more common in patients with a familial history of CeAD than in those with sporadic CeAD (p=0.036; OR=11.2; 95% CI=1.2-107). Conclusion: The findings suggest that rare genetic imbalance affecting cardiovascular system development may contribute to the risk of CeAD. Validation of these findings in independent study populations is warranted., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2017
36. Prevention Strategies for Cardioembolic Stroke: Present and Future Perspectives
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Giacalone, Giacomo, Abbas, Mohammed Abballa, and Corea, Francesco
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Cardioembolic stroke ,risk factors ,antithrombotic drugs ,atrial fibrillation ,PFO ,Article ,secondary prevention - Abstract
Atrial fibrillation (AF) is the most common cause of cardioembolism. An update on secondary prevention strategies, used to protect patients from the risk of stroke in many common cardiac conditions, is presented in the paper. The main line of actions of stroke prevention in cardioembolism is mostly connected with antithrombotic drugs, but also other, more invasive, techniques are quickly emerging. Also the classic pharmacological prevention with coumarins may soon be overcome by new generation anticoagulants. Is an aggressive treatment of Patent Foramen Ovale (PFO) always recommended? One of the main challenges of the future years will be to understand competitiveness between old and new preventive strategies.
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- 2010
37. Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects
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Giacalone, Giacomo, primary, Zanoletti, Marta, additional, Contini, Davide, additional, Re, Rebecca, additional, Spinelli, Lorenzo, additional, Roveri, Luisa, additional, and Torricelli, Alessandro, additional
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- 2017
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38. TIME-DOMAIN NEAR-INFRARED SPECTROSCOPY OXYGENATION PARAMETERS IN HEALTHY VOLUNTEERS AND IN ACUTE ISCHEMIC STROKE PATIENTS ACCORDING TO BRAIN TISSUE AND VASCULAR STATUS.
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Giacalone, Giacomo, primary
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- 2017
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39. Genetic Imbalance in Patients with Cervical Artery Dissection
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Grond-Ginsbach, Caspar, primary, Chen, Bowang, additional, Krawczak, Michael, additional, Pjontek, Rastislav, additional, Ginsbach, Philip, additional, Jiang, Yanxiang, additional, Abboud, Sherine, additional, Arnold, Marie-Luise, additional, Bersano, Anna, additional, Brandt, Tobias, additional, Caso, Valeria, additional, Debette, Stephanie, additional, Dichgans, Martin, additional, Geschwendtner, Andreas, additional, Giacalone, Giacomo, additional, Martin, Juan-Jose, additional, Metso, Antti, additional, Metso, Tiina, additional, Grau, Armin, additional, Kloss, Manja, additional, Lichy, Christoph, additional, Pezzini, Alessandro, additional, Traenka, Christopher, additional, Schreiber, Stefan, additional, Thijs, Vincent, additional, Touze, Emmanuel, additional, Zotto, Elisabetta, additional, Tatlisumak, Turgut, additional, Leys, Didier, additional, Lyrer, Philippe, additional, Engelter, Stefan, additional, and for the CADISP group, Bentham Science Publisher, additional
- Published
- 2017
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- View/download PDF
40. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection
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Debette, Stéphanie, Kamatani, Yoichiro, Wolf, Christiane, Agabiti Rosei, Enrico, Lanfranconi, Silvia, Ferrarese, Carlo, Susani, Emanuela, Bicocca, Milano, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Paciaroni, Maurizio, Ballabio, Elena, Dittrich, Ralf, Parati, Eugenio A, Ciusani, Emilio, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Touzé, Emmanuel, Altintas, Ayse, Martin, Juan José, Kittner, Steven, MItchell, Braxton, Stine, Colin, O'Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J, de Lau, Lonneke M L, Hofman, Albert, Southerland, Andrew M, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Samson, Yves, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Abboud, Shérine, Béjot, Yannick, Caso, Valeria, Bersano, Anna, Gschwendtner, Andreas, Metso, Tiina M, Sessa, Maria, Cole, John, Lamy, Chantal, Medeiros, Elisabeth, Beretta, Simone, Bonati, Leo H, Grau, Armin J, Michel, Patrik, Majersik, Jennifer J, Sharma, Pankaj, Kloss, Manja, Kalashnikova, Ludmila, Nazarova, Maria, Dobrynina, Larisa, Bartels, Eva, Guillon, Benoit, van den Herik, Evita G, Fernandez-Cadenas, Israel, Jood, Katarina, Nalls, Michael A, De Leeuw, Frank-Erik, Chauhan, Ganesh, Jern, Christina, Cheng, Yu-Ching, Werner, Inge, Metso, Antti J, Lichy, Christoph, Lyrer, Philippe A, Brandt, Tobias, Boncoraglio, Giorgio B, Wichmann, Heinz-Erich, Gieger, Christian, Engelter, Stefan T, Johnson, Andrew D, Böttcher, Thomas, Castellano, Maurizio, Arveiler, Dominique, Ikram, M Arfan, Breteler, Monique M B, Padovani, Alessandro, Meschia, James F, Kuhlenbäumer, Gregor, Rolfs, Arndt, Pezzini, Alessandro, Worrall, Bradford B, Consortium, International Stroke Genetics, Ringelstein, Erich-Bernd, Zelenika, Diana, Tatlisumak, Turgut, Lathrop, Mark, Leys, Didier, Amouyel, Philippe, Dallongeville, Jean, Group, CADISP, Thijs, Vincent, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Markus, Hugh S, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vullier, Fabrice, Tzourio, Christophe, Dos Santos, Michael, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Dichgans, Martin, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Lorenza Muiesan, Maria, Salvetti, Massimo, Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Helsinki University Central Hospital [Finland] (HUCH), Heidelberg University Hospital [Heidelberg], University Hospital Basel [Basel], Università degli Studi di Brescia = University of Brescia (UniBs), University Hospitals Leuven [Leuven], Leuven Center for Cancer Biology (VIB-KU-CCB), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), University of Cambridge [UK] (CAM), Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), University of Virginia, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire de Neurochirurgie Expérimentale [Brussels] (ULB 257), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Università degli Studi di Perugia = University of Perugia (UNIPG), Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), Ospedale San Raffaele, University of Maryland School of Medicine, University of Maryland System, Service de neurologie [Amiens], CHU Amiens-Picardie, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Klinikum Ludwigshafen [Germany], Service of Neurology [CHUV, Lausanne, Switzerland], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), University of Utah School of Medicine [Salt Lake City], Institute of Cardiovascular Research (ICR2UL), Royal Holloway [University of London] (RHUL), Ashford and St Peter's hospitals NHS foundation trust, Russian Academy of Sciences [Moscow] (RAS), Centre for Cognition and Decision Making [HSE, Moscow], Institut of Cognitive Neuroscience [HSE, Moscow] (ICN), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE)-Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), Zentrum für neurologische Gefäßdiagnostik - Center for Neurological Vascular Diagnostics [Munich, Germany], Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Department of Neurology [Erasmus MC, Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Hospital Universitario Mutua de Terrassa, Vall d'Hebron University Hospital [Barcelona], Insitute of Neuroscience and Physiology, University of Gothenburg (GU), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], Schmieder Klinik [Heidelberg, Germany], Helmholtz Zentrum München = German Research Center for Environmental Health, Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), University Hospital Rostock, Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie, Université de Strasbourg (UNISTRA)-CHU Strasbourg-Les Hôpitaux Universitaires de Strasbourg (HUS)-Institut Régional du Cancer-Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Brescia, Mayo Clinic [Jacksonville], Institute of Experimental Medicine - Institut für Experimentelle Medizin [Kiel, Germany] (IEM), Christian-Albrechts-Universität zu Kiel (CAU), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre d'Etude du Polymorphisme Humain (CEPH), Université Paris Diderot - Paris 7 (UPD7)-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Fondation Jean Dausset, McGill University and Genome Quebec Innovation Centre, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université de Lille, Pharmacologie de la mort neuronale et de la plasticité cérébrale, IFR114-Université de Lille, Droit et Santé, Réseau International des Instituts Pasteur (RIIP), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, The CADISP study has been supported by INSERM, Lille 2 University, Institut Pasteur de Lille and Lille University Hospital and received funding from the European Regional Development Fund (FEDER funds) and Région Nord-Pas-de-Calais in the framework of Contrat de Projets Etat-Region 2007–2013 Région Nord-Pas-de-Calais (grant 09120030), Centre National de Génotypage, the Emil Aaltonen Foundation, the Paavo Ilmari Ahvenainen Foundation, the Helsinki University Central Hospital Research Fund, the Helsinki University Medical Foundation, the Päivikki and Sakari Sohlberg Foundation, the Aarne Koskelo Foundation, the Maire Taponen Foundation, the Aarne and Aili Turunen Foundation, the Lilly Foundation, the Alfred Kordelin Foundation, the Finnish Medical Foundation, the Orion Farmos Research Foundation, the Maud Kuistila Foundation, the Finnish Brain Foundation, the Biomedicum Helsinki Foundation, Projet Hospitalier de Recherche Clinique Régional, Fondation de France, Génopôle de Lille, Adrinord, the Basel Stroke Funds, the Käthe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences and the Swiss Heart Foundation.L.H.B., S.T.E. and P.A.L. were supported, in part, by a grant from the Swiss National Science Foundation (33CM30-124119). S.D. is supported by a Chair of Excellence from the French National Research Agency (ANR). S.D. and M.D. are supported by a grant from the Leducq Foundation. M.D. is supported by the Vascular Dementia Research Foundation. I.F.-C. is supported by the Miguel Servet programme (CP12/03298) from the Spanish Ministry of Health (Instituto de Salud Carlos III). G.K. is a member of the Deutsche Forschungsgemeinschaft Cluster of Excellence 'Inflammation at Interfaces'. P.S. is supported by a Department of Health (UK) senior fellowship. A.M.S. is supported by the American Heart Association/American Stroke Association National Clinical Research Program (AHA 3CRP14140001). V.T. is supported by Fonds Wetenschappelijk Onderzoek Flanders., CADISP Group, RIKEN Center for Integrative Medical Science, Università degli Studi di Brescia [Brescia], University of Virginia [Charlottesville], Service des Urgences Cérébro-Vasculaires [CHU Pitié-Salpêtrière]], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Laboratoire de Neurologie Expérimentale [ULB, Brussels, Belgium] (ULB 257), Université Libre de Bruxelles [Bruxelles] (ULB)-Hôpital Erasme (Bruxelles), Università degli Studi di Perugia (UNIPG), Technische Universität München [München] (TUM)-Ludwig-Maximilians-Universität München (LMU), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), National Research University Higher School of Economics [Moscow] (HSE)-National Research University Higher School of Economics [Moscow] (HSE), Radboud university [Nijmegen], Helmholtz-Zentrum München (HZM), Westfälische Wilhelms-Universität Münster (WWU), The authors thank the staff and participants of all CADISP centers for their important contributions., Service des Urgences Cérébro-Vasculaires [CHU Pitié-Salpétriêre], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fondation Jean Dausset-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Erasmus MC other, Epidemiology, Debette, S, Kamatani, Y, Metso, T, Kloss, M, Chauhan, G, Engelter, S, Pezzini, A, Thijs, V, Markus, H, Dichgans, M, Wolf, C, Dittrich, R, Touzé, E, Southerland, A, Samson, Y, Abboud, S, Béjot, Y, Caso, V, Bersano, A, Gschwendtner, A, Sessa, M, Cole, J, Lamy, C, Medeiros, E, Beretta, S, Bonati, L, Grau, A, Michel, P, Majersik, J, Sharma, P, Kalashnikova, L, Nazarova, M, Dobrynina, L, Bartels, E, Guillon, B, Van Den Herik, E, Fernandez Cadenas, I, Jood, K, Nalls, M, De Leeuw, F, Jern, C, Cheng, Y, Werner, I, Metso, A, Lichy, C, Lyrer, P, Brandt, T, Boncoraglio, G, Wichmann, H, Gieger, C, Johnson, A, Böttcher, T, Castellano, M, Arveiler, D, Ikram, M, Breteler, M, Padovani, A, Meschia, J, Kuhlenbäumer, G, Rolfs, A, Worrall, B, Ringelstein, E, Zelenika, D, Tatlisumak, T, Lathrop, M, Leys, D, Amouyel, P, Dallongeville, J, Lemmens R, P, and Ferrarese, C
- Subjects
Male ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Myocardial Infarction ,Genome-wide association study ,Carotid Artery, Internal, Dissection ,Gastroenterology ,epidemiology [Carotid Artery, Internal, Dissection] ,Brain Ischemia ,0302 clinical medicine ,Migraine Disorder ,Odds Ratio ,Finland ,Vertebral Artery Dissection ,0303 health sciences ,education.field_of_study ,epidemiology [Hypercholesterolemia] ,MESH: Middle Aged ,MESH: Polymorphism, Single Nucleotide ,Phactr-1 protein, human ,MESH: Brain Ischemia ,MESH: Follow-Up Studies ,3. Good health ,MESH: Myocardial Infarction ,Human ,medicine.medical_specialty ,Migraine Disorders ,Hypercholesterolemia ,MESH: Vertebral Artery Dissection ,Lower risk ,genetics [Brain Ischemia] ,Article ,Follow-Up Studie ,MESH: Carotid Artery, Internal, Dissection ,03 medical and health sciences ,Genetic ,SDG 3 - Good Health and Well-being ,genetics [Carotid Artery, Internal, Dissection] ,Genetics ,Genetic predisposition ,epidemiology [Brain Ischemia] ,Humans ,epidemiology [Vertebral Artery Dissection] ,Polymorphism ,education ,Alleles ,MESH: Humans ,genetics [Vertebral Artery Dissection] ,MESH: Adult ,Odds ratio ,Microfilament Protein ,medicine.disease ,Adult ,Female ,Follow-Up Studies ,Genetic Pleiotropy ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Hypertension ,Microfilament Proteins ,Middle Aged ,Obesity ,Risk Factors ,Polymorphism, Single Nucleotide ,MESH: Genome-Wide Association Study ,Carotid Artery ,MESH: Female ,030217 neurology & neurosurgery ,epidemiology [Finland] ,Cervical Artery ,Vertebral artery dissection ,epidemiology [Hypertension] ,MESH: Hypertension ,MESH: Risk Factors ,MESH: Obesity ,Stroke ,Allele ,Dissection ,MESH: Finland ,MESH: Genetic Predisposition to Disease ,MESH: Hypercholesterolemia ,Single Nucleotide ,MESH: Migraine Disorders ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,epidemiology [Myocardial Infarction] ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Population ,MESH: Genetic Pleiotropy ,physiology [Microfilament Proteins] ,Biology ,MESH: Microfilament Proteins ,Internal medicine ,ddc:570 ,medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,030304 developmental biology ,epidemiology [Obesity] ,Risk Factor ,MESH: Alleles ,[INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV] ,Internal ,MESH: Odds Ratio ,MESH: Male ,epidemiology [Migraine Disorders] ,genetics [Microfilament Proteins] - Abstract
Item does not contain fulltext Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio (OR) = 0.75, 95% confidence interval (CI) = 0.69-0.82; P = 4.46 x 10(-10)), with confirmation in independent follow-up samples (659 CeAD cases and 2,648 controls; P = 3.91 x 10(-3); combined P = 1.00 x 10(-11)). The rs9349379[G] allele was previously shown to be associated with lower risk of migraine and increased risk of myocardial infarction. Deciphering the mechanisms underlying this pleiotropy might provide important information on the biological underpinnings of these disabling conditions.
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- 2015
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41. Propensity Score–Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale
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Pezzini, Alessandro, primary, Grassi, Mario, additional, Lodigiani, Corrado, additional, Patella, Rosalba, additional, Gandolfo, Carlo, additional, Zini, Andrea, additional, DeLodovici, Maria Luisa, additional, Paciaroni, Maurizio, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Musolino, Rossella, additional, Calabrò, Rocco Salvatore, additional, Bovi, Paolo, additional, Adami, Alessandro, additional, Silvestrelli, Giorgio, additional, Sessa, Maria, additional, Cavallini, Anna, additional, Marcheselli, Simona, additional, Marco Bonifati, Domenico, additional, Checcarelli, Nicoletta, additional, Tancredi, Lucia, additional, Chiti, Alberto, additional, Del Zotto, Elisabetta, additional, Tomelleri, Giampaolo, additional, Spalloni, Alessandra, additional, Giorli, Elisa, additional, Costa, Paolo, additional, Giacalone, Giacomo, additional, Ferrazzi, Paola, additional, Poli, Loris, additional, Morotti, Andrea, additional, Piras, Valeria, additional, Rasura, Maurizia, additional, Simone, Anna Maria, additional, Gamba, Massimo, additional, Cerrato, Paolo, additional, Zedde, Maria Luisa, additional, Micieli, Giuseppe, additional, Melis, Maurizio, additional, Massucco, Davide, additional, Guido, Davide, additional, De Giuli, Valeria, additional, Bonaiti, Silvia, additional, D’Amore, Cataldo, additional, La Starza, Sara, additional, Iacoviello, Licia, additional, and Padovani, Alessandro, additional
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- 2016
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42. CHRNA7 Gene and Response to Cholinesterase Inhibitors in an Italian Cohort of Alzheimer’s Disease Patients
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Clarelli, Ferdinando, primary, Mascia, Elisabetta, additional, Santangelo, Roberto, additional, Mazzeo, Salvatore, additional, Giacalone, Giacomo, additional, Galimberti, Daniela, additional, Fusco, Federica, additional, Zuffi, Marta, additional, Fenoglio, Chiara, additional, Franceschi, Massimo, additional, Scarpini, Elio, additional, Forloni, Gianluigi, additional, Magnani, Giuseppe, additional, Comi, Giancarlo, additional, Albani, Diego, additional, and Martinelli Boneschi, Filippo, additional
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- 2016
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43. Time Domain Near Infrared Spectroscopy System for oxygen saturation assessment in stroke patients
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Contini, Davide, primary, Giacalone, Giacomo, additional, Spinelli, Lorenzo, additional, Re, Rebecca, additional, Zanoletti, Marta, additional, Roveri, Luisa, additional, and Torricelli, Alessandro, additional
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- 2016
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44. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection
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Brain, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, ZL Cerebrovasculaire Ziekten Medisch, Verpleegafd Vaatchirurgie D4 Oost, Debette, Stéphanie, Compter, A, Labeyrie, Marc Antoine, Uyttenboogaart, Maarten, Metso, Tina M., Majersik, Jennifer J., Goeggel-Simonetti, Barbara, Engelter, Stefan T., Pezzini, Alessandro, Bijlenga, Philippe, Southerland, Andrew M., Naggara, Olivier, Béjot, Yannick, Cole, John W., Ducros, Anne, Giacalone, Giacomo, Schilling, Sabrina, Reiner, Peggy, Sarikaya, Hakan, Specken-Welleweerd, Jantien, Kappelle, L. Jaap, de Borst, Gert Jan, Bonati, Leo H., Jung, Simon, Thijs, Vincent, Martin, Juan J., Brandt, Tobias, Grond-Ginsbach, Caspar, Kloss, Manja, Mizutani, Tohru, Minematsu, Kazuo, Meschia, James F., Pereira, Vitor M., Bersano, Anna, Touzé, Emmanuel, Lyrer, Philippe A., Leys, Didier, Chabriat, Hugues, Markus, Hugh S., Worrall, Bradford B., Chabrier, Stéphane, Baumgartner, Ralph, Stapf, Christian, Tatlisumak, Turgut, Arnold, Marcel, Bousser, Marie Germaine, Brain, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, ZL Cerebrovasculaire Ziekten Medisch, Verpleegafd Vaatchirurgie D4 Oost, Debette, Stéphanie, Compter, A, Labeyrie, Marc Antoine, Uyttenboogaart, Maarten, Metso, Tina M., Majersik, Jennifer J., Goeggel-Simonetti, Barbara, Engelter, Stefan T., Pezzini, Alessandro, Bijlenga, Philippe, Southerland, Andrew M., Naggara, Olivier, Béjot, Yannick, Cole, John W., Ducros, Anne, Giacalone, Giacomo, Schilling, Sabrina, Reiner, Peggy, Sarikaya, Hakan, Specken-Welleweerd, Jantien, Kappelle, L. Jaap, de Borst, Gert Jan, Bonati, Leo H., Jung, Simon, Thijs, Vincent, Martin, Juan J., Brandt, Tobias, Grond-Ginsbach, Caspar, Kloss, Manja, Mizutani, Tohru, Minematsu, Kazuo, Meschia, James F., Pereira, Vitor M., Bersano, Anna, Touzé, Emmanuel, Lyrer, Philippe A., Leys, Didier, Chabriat, Hugues, Markus, Hugh S., Worrall, Bradford B., Chabrier, Stéphane, Baumgartner, Ralph, Stapf, Christian, Tatlisumak, Turgut, Arnold, Marcel, and Bousser, Marie Germaine
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- 2015
45. Time-Resolved Near Infrared Spectroscopy in Ischemic Stroke Patients.
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Zanoletti, Marta, Giacalone, Giacomo, Contini, Davide, Re, Rebecca, Spinelli, Lorenzo, Germinario, Bruno, Roveri, Luisa, and Torricelli, Alessandro
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- 2019
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46. Time-resolved near infrared spectroscopy in ischemic stroke patients
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Dehghani, Hamid, Wabnitz, Heidrun, Zanoletti, Marta, Giacalone, Giacomo, Contini, Davide, Re, Rebecca, Spinelli, Lorenzo, Germinario, Bruno, Roveri, Luisa, and Torricelli, Alessandro
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- 2019
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47. Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
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Brambilla, Paola, Esposito, Federica, Lindstrom, Eva, Sorosina, Melissa, Giacalone, Giacomo, Clarelli, Ferdinando, Rodegher, Mariaemma, Colombo, Bruno, Moiola, Lucia, Ghezzi, Angelo, Capra, Ruggero, Collimedaglia, Laura, Coniglio, Gabriella, Celius, Elisabeth G., Galimberti, Daniela, Sørensen, Per Soelberg, Martinelli, Vittorio, Oturai, Annette B., Harbo, Hanne F., Hillert, Jan, Comi, Giancarlo, and Martinelli-Boneschi, Filippo
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- 2012
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48. MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers
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Martinelli-Boneschi, Filippo, Fenoglio, Chiara, Brambilla, Paola, Sorosina, Melissa, Giacalone, Giacomo, Esposito, Federica, Serpente, Maria, Cantoni, Claudia, Ridolfi, Elisa, Rodegher, Mariaemma, Moiola, Lucia, Colombo, Bruno, De Riz, Milena, Martinelli, Vittorio, Scarpini, Elio, Comi, Giancarlo, and Galimberti, Daniela
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- 2012
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49. Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke
- Author
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Pezzini, Alessandro, primary, Grassi, Mario, primary, Lodigiani, Corrado, primary, Patella, Rosalba, primary, Gandolfo, Carlo, primary, Zini, Andrea, primary, DeLodovici, Maria Luisa, primary, Paciaroni, Maurizio, primary, Del Sette, Massimo, primary, Toriello, Antonella, primary, Musolino, Rossella, primary, Calabrò, Rocco Salvatore, primary, Bovil, Paolo, primary, Adami, Alessandro, primary, Silvestrelli, Giorgio, primary, Sessa, Maria, primary, Cavallini, Anna, primary, Marcheselli, Simona, primary, Bonifati, Domenico Marco, primary, Checcarelli, Nicoletta, primary, Tancredi, Lucia, primary, Chiti, Alberto, primary, Del Zotto, Elisabetta, primary, Spalloni, Alessandra, primary, Costa, Paolo, primary, Giacalone, Giacomo, primary, Ferrazzi, Paola, primary, Poli, Loris, primary, Andrea, Morotti, primary, Maurizia, Rasura, primary, Simone, Anna Maria, primary, Gamba, Massimo, primary, Cerrato, Paolo, primary, Micieli, Giuseppe, primary, Melis, Maurizio, primary, Massucco, Davide, primary, De Giuli, Valeria, primary, Pepe, Daniele, primary, Iacoviello, Licia, primary, and Padovani, Alessandro, additional
- Published
- 2015
- Full Text
- View/download PDF
50. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study
- Author
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Paciaroni, Maurizio, primary, Inzitari, Domenico, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Balucani, Clotilde, additional, Grotta, James C., additional, Sarraj, Amrou, additional, Sung-Il, Sohn, additional, Chamorro, Angel, additional, Urra, Xabier, additional, Leys, Didier, additional, Henon, Hilde, additional, Cordonnier, Charlotte, additional, Dequatre, Nelly, additional, Aguettaz, Pierre, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Zini, Andrea, additional, Vallone, Stefano, additional, Dell’Acqua, Maria Luisa, additional, Menetti, Federico, additional, Nencini, Patrizia, additional, Mangiafico, Salvatore, additional, Barlinn, Kristian, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Bovi, Paolo, additional, Cappellari, Manuel, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Padovani, Alessandro, additional, Alexandrov, Andrei V., additional, Shahripour, Reza Bavarsad, additional, Sessa, Maria, additional, Giacalone, Giacomo, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, De Vito, Alessandro, additional, Azzini, Cristiano, additional, Saletti, Andrea, additional, Fainardi, Enrico, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Silvestrini, Mauro, additional, Ferrarese, Carlo, additional, Beretta, Simone, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vasdekis, Spyros N., additional, Consoli, Domenico, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Luda, Emilio, additional, Varbella, Ferdinando, additional, Galletti, Giampiero, additional, Invernizzi, Paolo, additional, Donati, Edoardo, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Corea, Francesco, additional, Sette, Massimo Del, additional, Monaco, Serena, additional, Riva, Maurizio, additional, Tassinari, Tiziana, additional, Scoditti, Umberto, additional, and Toni, Danilo, additional
- Published
- 2014
- Full Text
- View/download PDF
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