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4. Lifelong endurance exercise and its relation with coronary atherosclerosis

Author

De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Van De Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Willems, R, Heidbuchel, H, Claessen, G, Claeys, M, Hespel, P, Dresselaers, T, Miljoen, H, Belmans, A, Favere, Kasper, Vermeulen, D, Witvrouwen, I, Hansen, D, Eijnde, Bert Op't, Thijs, D, Vanvoorden, P, Van Soest, S, Master@Heart, Consortium, Master@Heart Consortium, Willems, Rik/0000-0002-5469-9609, Dausin, Christophe/0000-0001-7864-2968, Van de Heyning, Caroline/0000-0002-4661-4732, De Bosscher, Ruben, Dausin, Christophe, Claus, Piet, Bogaert, Jan, Dymarkowski, Steven, Goetschalckx, Kaatje, GHEKIERE, Olivier, van de Heyning, Caroline M., Van Herck, Paul, Paelinck, Bernard, El Addouli, Haroun, La Gerche, Andre, HERBOTS, Lieven, Willems , Rik, HEIDBUCHEL, Hein, CLAESSEN, Guido, Claeys, Mathias, Hespel, Peter, Dresselaers, Tom, Miljoen, Hielko, Belmans, Ann, Favere, Kasper, Vermeulen, Dorien, Witvrouwen, Isabel, HANSEN, Dominique, OP 'T EIJNDE, Bert, Thijs, Daisy, Vanvoorden, Peter, and Van Soest , Sofie

Subjects
Medicine and Health Sciences, Athlete's heart, Human medicine, Athlete’s heart, Cardiology and Cardiovascular Medicine, Coronary artery disease, Exercise, Computed tomography coronary angiography
Abstract

Aims The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial. Methods and results The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes, all male with a low cardiovascular risk profile, were included. Peak oxygen uptake quantified fitness. The primary endpoint was the prevalence of coronary plaques (calcified, mixed, and non-calcified) on computed tomography coronary angiography. Analyses were corrected for multiple cardiovascular risk factors. The median age was 55 (50-60) years in all groups. Lifelong and late-onset athletes had higher peak oxygen uptake than non-athletes [159 (143-177) vs. 155 (138-169) vs. 122 (108-138) % predicted]. Lifelong endurance sports was associated with having >= 1 coronary plaque [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.17-2.94], >= 1 proximal plaque (OR 1.96, 95% CI 1.24-3.11), >= 1 calcified plaques (OR 1.58, 95% CI 1.01-2.49), >= 1 calcified proximal plaque (OR 2.07, 95% CI 1.28-3.35), >= 1 non-calcified plaque (OR 1.95, 95% CI 1.12-3.40), >= 1 non-calcified proximal plaque (OR 2.80, 95% CI 1.39-5.65), and >= 1 mixed plaque (OR 1.78, 95% CI 1.06-2.99) as compared to a healthy non-athletic lifestyle. Conclusion Lifelong endurance sport participation is not associated with a more favourable coronary plaque composition compared to a healthy lifestyle. Lifelong endurance athletes had more coronary plaques, including more non-calcified plaques in proximal segments, than fit and healthy individuals with a similarly low cardiovascular risk profile. Longitudinal research is needed to reconcile these findings with the risk of cardiovascular events at the higher end of the endurance exercise spectrum. [GRAPHICS] . This study is supported by a research grant (T003717N) and R.W. is supported as a post-doctoral clinical researcher by the Fund for Scientific Research Flanders (FWO Vlaanderen), Brussels, Belgium The authors would like to thank the many staff members at the three sites for helping conduct this study. We would particularly like to thank the clinical research assistants Sofie van Soest, Dorien Vermeulen, and Daisy Thijs for their dedication and devoted efforts to include, test, and follow up participants. We would like to thank Ann Belmans for calculating the sample size and statistical advice. We would also like to thank Kris Van der Mieren (Sport- en keuringsartsen), Tom Teuglinckx (Sport- en keuringsartsen), Reynout Van Schuylenbergh (Triatlon Vlaanderen), Frank Glorieux (Cycling Vlaanderen), Paul Rowe (Sport Vlaanderen), Gert Van Goolen (Golazo), and Sven Nys (Golazo and godfather of Master@Heart) as members of the advisory committee for their insightful input on the design, the launch, and approach of the Master@Heart study.

Published
2023

5. Myocardial Perfusion

Author

Bogaert, J., Goetschalckx, K., Bogaert, Jan, editor, Dymarkowski, Steven, editor, Taylor, Andrew M., editor, and Muthurangu, Vivek, editor

Published
2012
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6. The prevalence and clinical significance of a reduced ventricular ejection fraction in asymptomatic young elite endurance athletes

Author

De Bosscher, R, primary, Janssens, K, additional, Dausin, C, additional, Goetschalckx, K, additional, Bogaert, J, additional, Ghekiere, O, additional, Van De Heyning, C, additional, Elliott, A, additional, Sanders, P, additional, Kalman, J, additional, Herbots, L, additional, Willems, R, additional, Heidbuchel, H, additional, La Gerche, A, additional, and Claessen, G, additional

Published
2022
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8. Contributors

Author

Anagnostopoulos, C.D., primary, Badano, L.P., additional, Baksi, A.J., additional, Bekkers, S.C.A.M., additional, Bischoff, B., additional, Bissell, M.M., additional, Braun, D., additional, Budde, R.P.J., additional, Buechel, R.R., additional, Camilleri, S., additional, Cappeliez, O., additional, Chow, B.J.W., additional, Coenen, A., additional, Cosyns, B., additional, Crean, A.M., additional, Dijkshoorn, M., additional, Donal, E., additional, Edvardsen, T., additional, Fernández-Golfín, C., additional, Ferreira, V.M., additional, Flotats, A., additional, Gaemperli, O., additional, Galderisi, M., additional, Galli, E., additional, Gaubert, J.-Y., additional, Gerber, B.L., additional, Gimelli, A., additional, Goetschalckx, K., additional, Greenwood, J.P., additional, Gurunathan, S., additional, Habets, J., additional, Habib, G., additional, Hasselberg, N.E., additional, Hausleiter, J., additional, Karamitsos, T.D., additional, Kaufmann, P.A., additional, Kietselaer, B.L., additional, Knaapen, P., additional, Lancellotti, P., additional, Lederlin, M., additional, Leeson, P., additional, Leiner, T., additional, Lombardi, M., additional, Lubberink, M., additional, Ludman, A.J., additional, Magalhães, T.A., additional, Mahjoub, H., additional, Mahnken, A., additional, Manrique, A., additional, Marra, M.P., additional, Motwani, M., additional, Muraru, D., additional, Neubauer, S., additional, Nieman, K., additional, Paelinck, B., additional, Pasquet, A.A., additional, Pennell, D.J., additional, Petersen, S.E., additional, Pibarot, P., additional, Pison, L., additional, Plein, S., additional, Polsani, V., additional, Premaratne, M., additional, Pugliese, F., additional, Rademakers, F.E., additional, Robson, M.D., additional, Rochitte, C.E., additional, Salgado, R., additional, Schulz-Menger, J., additional, Senior, R., additional, Singh, P., additional, Tawakol, A., additional, Tyler, D.J., additional, Vannan, M., additional, Wassmuth, R., additional, Zamorano, J., additional, and Zhou, X., additional

Published
2015
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10. Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial

Author

Hochman, JS, Reynolds, HR, Bangalore, S, O'Brien, SM, Alexander, KP, Senior, R, Boden, WE, Stone, GW, Goodman, SG, Lopes, RD, Lopez-Sendon, J, White, HD, Maggioni, AP, Shaw, LJ, Min, JK, Picard, MH, Berman, DS, Chaitman, BR, Mark, DB, Spertus, JA, Cyr, DD, Bhargava, B, Ruzyllo, W, Wander, GS, Chernyavskiy, AM, Rosenberg, YD, Maron, DJ, Mavromatis, K, Miller, T, Banerjee, S, Abdul-Nour, K, Stone, PH, Jang, JJ, Weitz, S, Arnold, S, Shapiro, MD, El-Hajjar, M, McFalls, EO, Khouri, MG, Goldberg, JL, Goldweit, R, Cohen, RA, Winchester, DE, Kronenberg, M, Heitner, JF, Dauber, IM, Cannan, C, Sudarshan, S, Mehta, PK, Hedgepeth, CM, Sahul, Z, Booth, D, Setty, S, Barua, RS, Hage, F, Dajani, K, Arif, I, Trejo (Gutierrez), JF, Gemignani, A, Meadows, JL, Call, JT, Hannan, J, Martin, ET, Vorobiof, G, Moorman, A, Kinlay, S, Rayos, G, Seedhom, A, Kumkumian, G, Sedlis, SP, Tamis-Holland, JE, Saba, S, Badami, U, Marzo, K, Robbins, IH, Hamroff, GS, Little, RW, Lui, CY, Hu, B, Labovitz, AJ, Rodriguez, F, Deedwania, P, Sweeny, J, Spizzieri, C, Hochberg, CP, Salerno, WD, Wyman, R, Zarka, A, Haldis, T, Kohn, JA, Girotra, S, Almousalli, O, Krishnam, MS, Coram, R, Thomas, S, El Shahawy, M, Stafford, J, Abernethy, WB, Zurick, A, Meyer, TM, Rutkin, B, Bokhari, S, Sokol, SI, Hamzeh, I, Turner, MC, Good, AP, Shammas, NW, Chilton, R, Nguyen, PK, Jezior, M, Gordon, PC, Stenberg, R, Pedalino, RP, Wiesel, J, Juang, GJ, Al-Amoodi, M, Wohns, D, Lader, EW, Mumma, M, Dharmarajan, L, McGarvey, JFX, Downes, TR, Cheong, B, Potluri, S, Mastouri, RA, Li, D, Giedd, K, Old, W, Burt, F, Sokhon, K, Gopal, D, Valeti, US, Kobashigawa, J, Govindan, SC, Manjunath, CN, Pandit, N, Dwivedi, SK, Mathew, A, Gadkari, MA, Satheesh, S, Mathur, A, Christopher, J, Oomman, A, Naik, S, Grant, P, Kachru, R, Kumar, A, Kaul, U, Gamma, RA, De Belder, MA, Nageh, T, Lindsay, SJ, Hoye, A, Donnelly, P, Chauhan, A, Barr, C, Alfakih, K, Henriksen, P, Okane, P, De Silva, R, Conway, DSG, Sirker, AA, Hoole, SP, Witherow, FN, Johnston, N, Luckie, M, Sobolewska, J, Jeetley, P, Travill, C, Braganza, D, Henderson, R, Berry, C, Moriarty, AJ, Glover, JD, Mikhail, G, Gosselin, G, Diaz, A, Phaneuf, DC, Garg, P, Chow, BJW, Bainey, KR, Cheema, AN, Cha, J, Howarth, AG, Wong, G, Uxa, A, Galiwango, P, Lam, A, Mehta, S, Udell, J, Genereux, P, Hameed, A, Daba, L, Hueb, W, Smanio, PEP, De Quadros, AS, Vitola, JV, Marin-Neto, JA, Polanczyk, CA, Carvalho, AC, Alves Junior, AR, Dracoulakis, MDA, Figueiredo, E, Caramori, PR, Tumelero, R, Dall'Orto, F, Mesquita, CT, Ribeiro da Silva, EE, Saraiva, JF, Costantini, C, Demkow, M, Mazurek, T, Drozdz, J, Szwed, H, Witkowski, A, Gajos, G, Pruszczyk, P, Loboz-Grudzien, K, Lesiak, M, Reczuch, KW, Kalarus, Z, Musial, WJ, Bockeria, L, Bershtein, LL, Demchenko, EA, Lopez-Sendon, JL, Peteiro, J, Gonzalez Juanatey, JR, Sionis, A, Miro, V, Ortuno, FM, Blancas, MG, Luena, JEC, Fernandez-Aviles, F, Chen, J, Wu, Y, Ma, Y, Ji, Z, Yang, X, Lin, W, Zeng, H, Fu, X, Yang, B, Wang, S, Cheng, G, Zhao, Y, Fang, X, Zeng, Q, Su, X, Li, Q, Nie, S-P, Yu, Q, Wang, J, Zhang, S, Perna, GP, Provasoli, S, Monti, L, Di Chiara, A, Mortara, A, Galvani, M, Sicuro, M, Calabro, P, Tarantini, G, Racca, E, Briguori, C, Amati, R, Russo, A, Poh, K-K, Foo, D, Chua, T, Doerr, R, Sechtem, U, Schulze, PC, Nickenig, G, Schuchlenz, H, Lang, IM, Huber, K, Vertes, A, Varga, A, Fontos, G, Merkely, B, Kerecsen, G, Hinic, S, Beleslin, BD, Cemerlic-Adjic, N, Davidovic, G, Dekleva, MN, Stankovic, G, Apostolovic, S, Escobedo, J, Rosas, EA, Selvanayagam, JB, Thambar, ST, Beltrame, JF, Hillis, GS, Thuaire, C, Steg, P-G, Slama, MS, El Mahmoud, R, Nicollet, E, Barone-Rochette, G, Furber, A, Laucevicius, A, Kedhi, E, Riezebos, RK, Suryapranata, H, Ramos, R, Pinto, FJ, Ferreira, N, Guzman, L, Figal, JC, Alvarez, C, Courtis, J, Schiavi, L, Rubio, M, Devlin, GP, Stewart, RAH, Kedev, S, Held, C, Aspberg, J, Sharir, T, Kerner, A, Fukuda, K, Yasuda, S, Nishimura, S, Goetschalckx, K, Hung, C-L, Ntsekhe, M, Moccetti, T, Abdelhamid, M, Pop, C, Popescu, BA, Al-Mallah, MH, Ramos, WEM, Kuanprasert, S, Yamwong, S, Khairuddin, A, Ferguson, B, Harrington, R, Williams, D, Berger, J, Newman, J, Sidhu, M, Dzavik, V, Jiang, L, Keltai, M, Kohsaka, S, Maggioni, A, Mancini, GBJ, Merz, CNB, Weintraub, W, Ballantyne, C, Calfas, KJ, Davidson, M, Friedrich, M, Hachamovitch, R, Kwong, R, Harrell, F, Kullo, I, McManus, B, Cohen, DJ, Bugiardini, R, Celutkiene, J, Lyubarova, R, Mattina, D, Nwosu, S, Broderick, S, Cyr, D, Rockhold, F, Anstrom, K, Jones, P, Phillips, L, Hayes, SW, Friedman, JD, Gerlach, RJ, Kwong, RY, Mongeon, FP, Hung, J, Scherrer-Crosbie, M, Zeng, X, Ali, Z, Arsanjani, R, Budoff, M, Leipsic, J, Nakanishi, R, Youn, T, Orso, F, Zhang, H, Zhang, L, Diaz, R, Van de Werf, F, Fleg, J, Kirby, R, Jeffries, N, and Hochman JS, Reynolds HR, Bangalore S, O'Brien SM, Alexander KP, Senior R, Boden WE, Stone GW, Goodman SG, Lopes RD, Lopez-Sendon J, White HD, Maggioni AP, Shaw LJ, Min JK, Picard MH, Berman DS, Chaitman BR, Mark DB, Spertus JA, Cyr DD, Bhargava B, Ruzyllo W, Wander GS, Chernyavskiy AM, Rosenberg YD, Maron DJ, Mavromatis K, Miller T, Banerjee S, Abdul-Nour K, Stone PH, Jang JJ, Weitz S, Arnold S, Shapiro MD, El-Hajjar M, McFalls EO, Khouri MG, Goldberg JL, Goldweit R, Cohen RA, Winchester DE, Kronenberg M, Heitner JF, Dauber IM, Cannan C, Sudarshan S, Mehta PK, Hedgepeth CM, Sahul Z, Booth D, Setty S, Barua RS, Hage F, Dajani K, El-Hajjar M, Arif I, Trejo JF, Gemignani A, Meadows JL, Call JT, Hannan J, Martin ET, Vorobiof G, Moorman A, Kinlay S, Rayos G, Seedhom A, Kumkumian G, Sedlis SP, Tamis-Holland JE, Saba S, Badami U, Marzo K, Robbins IH, Hamroff GS, Little RW, Lui CY, Booth D, Hu B, Labovitz AJ, Maron DJ, Rodriguez F, Deedwania P, Sweeny J, Spizzieri C, Hochberg CP, Salerno WD, Wyman R, Zarka A, Haldis T, Kohn JA, Girotra S, Almousalli O, Krishnam MS, Coram R, Thomas S, El Shahawy M, Stafford J, Abernethy WB, Zurick A, Meyer TM, Rutkin B, Bokhari S, Sokol SI, Hamzeh I, Turner MC, Good AP, Shammas NW, Chilton R, Nguyen PK, Jezior M, Gordon PC, Stenberg R, Pedalino RP, Wiesel J, Juang GJ, Al-Amoodi M, Wohns D, Lader EW, Mumma M, Dharmarajan L, McGarvey JFX, Downes TR, Cheong B, Potluri S, Mastouri RA, Li DY, Giedd K, Old W, Burt F, Sokhon K, Gopal D, Valeti US, Kobashigawa J, Govindan SC, Manjunath CN, Pandit N, Dwivedi SK, Wander G, Bhargava B, Mathew A, Gadkari MA, Satheesh S, Mathur A, Christopher J, Oomman A, Naik S, Christopher J, Grant P, Kachru R, Kumar A, Christopher J, Kaul U, Gamma RA, de Belder MA, Nageh T, Lindsay SJ, Hoye A, Donnelly P, Chauhan A Barr C, Alfakih K, Henriksen P, Okane P, de Silva R, Conway DSG, Sirker AA, Hoole SP, Witherow FN, Johnston N, Luckie M, Sobolewska J, Jeetley P, Travill C, Braganza D, Henderson R, Berry C, Moriarty AJ, Glover JD, Mikhail G, Gosselin G, Diaz A, Phaneuf DC, Garg P, Chow BJW, Bainey KR, Cheema AN, Cheema AN, Cha J, Howarth AG, Wong G, Uxa A, Galiwango P, Lam A, Mehta S, Udell J, Genereux P, Hameed A, Daba L, Hueb W, Smanio PEP, de Quadros AS, Vitola JV, Marin-Neto JA, Polanczyk CA, Carvalho AC, Alves AR, Dracoulakis MDA, Figueiredo E, Caramori PR, Tumelero R, Dall'Orto F, Mesquita CT, da Silva EER, Saraiva JF, Costantini C, Demkow M, Mazurek T, Drozdz J, Szwed H, Witkowski A, Gajos G, Pruszczyk P, Loboz-Grudzien K, Lesiak M, Reczuch KW, Kalarus Z, Musial WJ, Bockeria L, Chernyavskiy AM, Bershtein LL, Demchenko EA, Lopez-Sendon JL, Peteiro J, Juanatey JRG, Sionis A, Miro V, Ortuno FM, Blancas MG, Luena JEC, Fernandez-Aviles F, Chen JY, Wu YJ, Ma YT, Ji Z, Yang XC, Lin WH, Zeng HS, Fu, X, Yang B, Wang ST, Cheng G, Zhao YL, Fang XH, Zeng QT, Su X, Li QX, Nie SP, Yu Q, Wang JA, Zhang SY, Perna GP, Provasoli S, Monti L, Di Chiara A, Mortara A, Galvani M, Sicuro M, Calabro P, Tarantini G, Racca E , Briguori C, Amati R, Russo A, Poh KK, Foo D, Chua, Doerr R, Sechtem U, Schulze PC, Nickenig G, Schuchlenz H, Lang IM, Huber K, Vertes A, Varga A, Fontos G, Merkely B, Kerecsen G, Hinic S, Beleslin BD, Cemerlic-Adjic N, Davidovic G, Dekleva MN, Stankovic G, Apostolovic S, Escobedo J, Rosas EA, Selvanayagam JB, Thambar ST, Beltrame JF, Hillis GS, Thuaire C, Steg PG, Slama MS, El Mahmoud R, Nicollet E, Barone-Rochette G, Furber A, Laucevicius A, Kedhi E, Riezebos RK, Suryapranata H, Ramos R, Pinto FJ, Ferreira N, Guzman L, Figal JC, Alvarez C, Courtis J, Schiavi L, Rubio M, Devlin GP, Stewart RAH, Kedev S, Held C, Aspberg, J, Sharir T, Kerner A, Fukuda K, Yasuda S, Nishimura S , Goetschalckx K, Hung CL, Ntsekhe M, Moccetti T, Abdelhamid M, Pop C, Popescu BA, Al-Mallah MH, Ramos WEM, Kuanprasert S, Yamwong S, Khairuddin A, O'Brien SM, Boden WE, Ferguson B, Harrington R, Stone GW, Williams D, Berger J, Newman J, Sidhu M, Mark DB, Shaw LJ, Spertus JA, Berman DS, Chaitman BR, Doerr R, Dzavik V, Goodman SG, Gosselin G, Held C, Jiang LX, Keltai M, Kohsaka S, Lopes RD, Lopez-Sendon JL, Maggioni A, Mancini GBJ, Merz CNB, Min JK, Picard MH, Ruzyllo W, Selvanayagam JB, Senior R, Steg PG, Szwed H, Weintraub W, White HD, Ballantyne C, Calfas KJ, Davidson M, Stone PH, Friedrich M, Hachamovitch R, Kwong R, Harrell F, Kullo I, McManus B, Cohen DJ, Bugiardini R, Celutkiene J, Escobedo J , Hoye A, Lyubarova R, Mattina D, Peteiro J, Nwosu S, Broderick S, Cyr D, Rockhold F, Anstrom K, Jones P, Phillips L, Hayes SW, Friedman JD, Gerlach RJ, Kwong RY, Mongeon FP, Hung J, Scherrer-Crosbie M, Zeng X, Ali Z, Genereux P, Arsanjani R, Budoff M, Leipsic J, Nakanishi R, Youn T , Orso F, Carvalho AC, Zhang HB, Zhang LH, Diaz R, Van de Werf F, Goetschalckx K, Rosenberg YD, Fleg J, Kirby R, Jeffries N.

Subjects
medicine.medical_specialty, Cardiac & Cardiovascular Systems, IMPACT, medicine.medical_treatment, Population, 030204 cardiovascular system & hematology, Revascularization, law.invention, MEDICAL THERAPY, ISCHEMIA Research Group, Angina, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Severity of illness, SCORE, medicine, BENEFIT, 030212 general & internal medicine, cardiovascular diseases, education, education.field_of_study, OUTCOMES, Science & Technology, business.industry, PCI, medicine.disease, Clinical trial, PROGNOSTIC VALUE, Stenosis, Cardiology, Cardiovascular System & Cardiology, CORONARY-ARTERY-DISEASE, REVASCULARIZATION, Cardiology and Cardiovascular Medicine, business, ECHOCARDIOGRAPHY, Life Sciences & Biomedicine
Abstract

Importance It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. Design, Setting, and Participants The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (

Published
2019

12. Endurance exercise and the risk of cardiovascular pathology in men: a comparison between lifelong and late-onset endurance training and a non-athletic lifestyle-rationale and design of the Master@Heart study, a prospective cohort trial

Author

De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Belmans, A, Van de Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Heidbuchel, H, Willems, R, Claessen, G, De Bosscher, R, Dausin, C, Claus, P, Bogaert, J, Dymarkowski, S, Goetschalckx, K, Ghekiere, O, Belmans, A, Van de Heyning, CM, Van Herck, P, Paelinck, B, El Addouli, H, La Gerche, A, Herbots, L, Heidbuchel, H, Willems, R, and Claessen, G

Abstract

INTRODUCTION: Low and moderate endurance exercise is associated with better control of cardiovascular risk factors, a decreased risk of coronary artery disease and atrial fibrillation (AF). There is, however, a growing proportion of individuals regularly performing strenuous and prolonged endurance exercise in which the health benefits have been challenged. Higher doses of endurance exercise have been associated with a greater coronary atherosclerotic plaque burden, risk of AF and myocardial fibrosis (MF). METHODS AND ANALYSIS: Master@Heart is a multicentre prospective cohort study aiming to assess the incidence of coronary atherosclerosis, AF and MF in lifelong endurance athletes compared to late-onset endurance athletes (initiation of regular endurance exercise after the age of 30 years) and healthy non-athletes.The primary endpoint is the incidence of mixed coronary plaques. Secondary endpoints include coronary calcium scores, coronary stenosis >50%, the prevalence of calcified and soft plaques and AF and MF presence. Tertiary endpoints include ventricular arrhythmias, left and right ventricular function at rest and during exercise, arterial stiffness and carotid artery intima media thickness.Two hundred male lifelong athletes, 200 late-onset athletes and 200 healthy non-athletes aged 45-70 will undergo comprehensive cardiovascular phenotyping using CT, coronary angiography, echocardiography, cardiac MRI, 12-lead ECG, exercise ECG and 24-hour Holter monitoring at baseline. Follow-up will include online tracking of sports activities, telephone calls to assess clinical events and a 7-day ECG recording after 1 year. ETHICS AND DISSEMINATION: Local ethics committees approved the Master@Heart study. The trial was launched on 18 October 2018, recruitment is complete and inclusions are ongoing. TRIAL REGISTRATION NUMBER: NCT03711539.

Published
2021

14. Hinge point fibrosis in athletes is not associated with structural, functional or electrical consequences: a comparison between young and middle-aged elite endurance athletes

Author

De Bosscher, R, primary, Claeys, M, additional, Dausin, C, additional, Goetschalckx, K, additional, Bogaert, J, additional, Van De Heyning, C, additional, Ghekiere, O, additional, Herbots, L, additional, Claus, P, additional, Kalman, J, additional, Sanders, P, additional, Elliott, A, additional, Heidbuchel, H, additional, La Gerche, A, additional, and Claessen, G, additional

Published
2020
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15. Left heart Impella-device to bridge acute mitral regurgitation to MitraClip-procedure: a novel implementation of percutaneous mechanical circulatory support

Author

Vandenbriele, C, primary, Balthazar, T, additional, Wilson, J, additional, Ledot, S, additional, Smith, R, additional, Caetano, A.F, additional, Adriaenssens, T, additional, Goetschalckx, K, additional, Janssens, S, additional, Dubois, C, additional, Jacobs, S, additional, Meyns, B, additional, Davies, S, additional, and Price, S, additional

Published
2020
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23. A randomized study of home-based training intervention with telemonitoring guidance in coronary artery disease patients - (TRiCH) Study

Author

Avila, A, Claes, J, Goetschalckx, K, Buys, R, Azzawi, M, Vanhees, L, and Cornelissen, V

Abstract

Background: Cardiac rehabilitation (CR) is an essential part of coronary heart disease (CHD) management. However, patients exiting a center-based CR program have difficulty retaining its benefits. Objective: The purpose of the TRiCH study is to evaluate the added benefit of a home-based (HB) CR program with telemonitoring guidance on physical fitness in patients with coronary artery disease (CAD) who are being discharged from a phase II ambulatory CR program, and to compare its effectiveness to a prolonged center-based (CB) CR intervention. Methods: Between February 2014 and August 2016, 90 CAD patients (61.2±7.6yrs, 89% males, 1.73±0.7m, 82.9±13kg, 27.5±3.4kg/m2) who successfully completed a three month ambulatory CR program were randomly allocated to one of three groups: HB (=30), CB (=30) or a control group (CG) (=30) on a 1:1:1 basis. HB patients received a home-based exercise intervention with telemonitoring guidance consisting of weekly emails or phone calls, CB patients continued the ambulatory-hospital CR and CG patients received usual care including the recommendation to remain physically active. All patients underwent cardiopulmonary exercise testing to assess peak oxygen uptake (VO2P) at baseline and after the 12 week intervention period. Secondary outcomes included physical activity behavior, anthropometric characteristics, cardiovascular risk factors and quality of life. Results: The increase in VO2P was larger following 12 weeks of intervention in the CB group (P = .03) and HB group (P = .04) compared to the control group. In addition, oxygen uptake at the first ventilatory threshold (P-interaction = .03) and the second ventilatory threshold (P-interaction = .03) increased significantly more in the HB group compared to CB. No significant changes were found in the secondary outcomes. Conclusions: Adding a HB exercise program with telemonitoring guidance following completion of a phase II ambulatory CR program results in further improvement of physical fitness and is as equally effective as prolonging a CB CR in patients with coronary artery disease.

Published
2018

30. ORAL AB QUICK FIRE I1496Myocardial substrates underlyng early ventricular arrhythmias in st-elevation acute myocardial infarction: the role of cardiac magnetic resonance1416Cardiac magnetic resonance predicts atrial fibrillation occurrence in patients with hypertrophic cardiomyopathy1469T1 and T2 mapping cardiovascular magnetic resonance to monitor inflammatory activity in patients with myocarditis1480Impact of electronic coaching on cardiovascular risk reduction in a high-risk primary prevention population – A cardiovascular magnetic resonance sub-study1598Anatomical and functional evaluation of postinterventional pulmonary vein stenosis by magnetic resonance imaging1364Reduced infarct-adjacent wall thickening and impaired restperfusion in the area at risk of successfully reperfused acute myocardial infarction1580Correlation between circulating microRNA 29 and diffuse myocardial fibrosis, assessed by T1 mapping, in patients affected by non ischemic dilative cardiomyopathy1435Association of Smoking with Myocardial Injury and Clinical Outcome in Patients Undergoing Mechanical Reperfusion for ST-Elevation Myocardial Infarction1640Assessing the risk of late cardiotoxicity in low risk breast cancer survivors receiving contemporary anthracycline treatment: a 6 year 100 patient study1511Risk stratification in sarcoidosis: Incidence of cardiac sarcoidosis in individuals diagnosed with extra-cardiac disease by cardiovascular magnetic resonance1334Patterns of late gadolinium enhancement in Brugada syndrome1591Detailed Left Atrial Assessment in Anderson Fabry Disease1634Role of cardiac magnetic resonance in the diagnosis of ARVC/D mimics1321Comparison of transtlioracic ecliocardiography versus cardiac magnetic for implantable cardioverter defibrillator therapy in primary prevention strategy dilated cardiomyopathy patients: Table 1.

Author

Angela, Susana, primary, Camaioni, Claudia, primary, Bohnen, S., primary, Khanji, Mohammed Y., primary, Hilbert, Sebastian, primary, Goetschalckx, K., primary, Calvieri, C., primary, Reinstadler, Sebastian J., primary, Maestrini, Viviana, primary, James, S., primary, Bastiaenen, Rachel, primary, Reid, A. B., primary, Amadu, A.M., primary, Pontone, Gianluca, primary, Alberto, Cipriani, additional, Manuel, De Lazzari, additional, Federico, Marin, additional, Francesca, Prevedello, additional, Bendetta, Giorgi, additional, Giorgio, De Conti, additional, Giuseppe, Tarantini, additional, Luisa, Cacciavillani, additional, Emanuele, Bertaglia, additional, Domenico, Corrado, additional, Sabino, Iliceto, additional, Martina, Perazzolo Marra, additional, Morlon, Lucas, additional, Vergé, Marie-Philippe, additional, Jais, Pierre, additional, Roudaut, Raymond, additional, Laurent, François, additional, Lafitte, Stéphane, additional, Cochet, Hubert, additional, Réant, Patricia, additional, Radunski, U. K., additional, Lund, G. K., additional, Senel, M., additional, Avanesov, M., additional, Tahir, E., additional, Stehning, C., additional, Adam, G., additional, Blankenberg, S., additional, Muellerleile, K., additional, Balawon, Armida, additional, Boubertakh, Redha, additional, Petersen, Steffen E, additional, Spampinato, Ricardo, additional, Oebel, Sabrina, additional, Hindricks, Gerhard, additional, Bollmann, Andreas, additional, Jahnke, Cosima, additional, Paetsch, Ingo, additional, Bogaert, J., additional, Desmet, W., additional, Toth, A., additional, Merkely, B., additional, Janssens, S., additional, Claus, P., additional, Preda, M. B., additional, Perfetti, A., additional, Valaperta, R., additional, Secchi, F., additional, Fedele, F., additional, Martelli, F., additional, Lombardi, M., additional, Eitel, Charlotte, additional, Fuernau, Georg, additional, de Waha, Suzanne, additional, Desch, Steffen, additional, Mende, Meinhard, additional, Metzler, Bernhard, additional, Schuler, Gerhard, additional, Thiele, Holger, additional, Eitel, Ingo, additional, Mun, Hong Cheang, additional, Kotwinski, Paul, additional, Rosmini, Stefania, additional, Sanders, Julie, additional, Lloyd, Guy, additional, Dudley, J. Pennell, additional, Kellman, Peter, additional, Hugh, E. Montgomery, additional, Manisty, Charlotte, additional, James, C. Moon, additional, Waterhouse, D.F., additional, Murphy, T.M., additional, Kenny, C., additional, O'Hanlon, R., additional, Cox, Andrew T., additional, Wijeyeratne, Yanushi, additional, Colbeck, Nicholas, additional, Pakroo, Nadia, additional, Ahmed, Hammad, additional, Bunce, Nick, additional, Anderson, Lisa, additional, Prasad, Sanjay, additional, Sharma, Sanjay, additional, Behr, Elijah R., additional, Miller, C., additional, Jovanovic, A., additional, Woolfson, P., additional, Abidin, N., additional, Schmitt, M., additional, Rodrigues, J.C.L., additional, Dastidar, A. Ghosh, additional, Baritussio, A., additional, Lawton, C., additional, Venuti, G., additional, Meloni, G.B., additional, Conti, M., additional, Bucciarelli-Ducci, C., additional, Andreini, Daniele, additional, SoLbiati, Anna, additional, Guglielmo, Marco, additional, Mushtaq, Saima, additional, Baggiano, Andrea, additional, Beltrama, Virginia, additional, Rota, Cristina, additional, Guaricci, Andrea I., additional, and Pepi, Mauro, additional

Published
2016
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31. Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease: The SAINTEX-CAD study

Author

Conraads, V., Pattyn, N., de Maeyer, C., Beckers, P., Coeckelberghs, E., Cornelissen, V.A., Denollet, J., Frederix, G., Goetschalckx, K., Hoymans, V.Y., Possemiers, N., Schepers, D., Shivalkar, B., Voigt, J.U., van Craenenbroeck, E.M., Vanhees, L., Conraads, V., Pattyn, N., de Maeyer, C., Beckers, P., Coeckelberghs, E., Cornelissen, V.A., Denollet, J., Frederix, G., Goetschalckx, K., Hoymans, V.Y., Possemiers, N., Schepers, D., Shivalkar, B., Voigt, J.U., van Craenenbroeck, E.M., and Vanhees, L.

Abstract

Background Exercise-based cardiac rehabilitation increases peak oxygen uptake (peak VO2), which is an important predictor of mortality in cardiac patients. However, it remains unclear which exercise characteristics are most effective for improving peak VO2 in coronary artery disease (CAD) patients. Proof of concept papers comparing Aerobic Interval Training (AIT) and Moderate Continuous Training (MCT) were conducted in small sample sizes and findings were inconsistent and heterogeneous. Therefore, we aimed to compare the effects of AIT and Aerobic Continuous Training (ACT) on peak VO2, peripheral endothelial function, cardiovascular risk factors, quality of life and safety, in a large multicentre study. Methods Two-hundred CAD patients (LVEF > 40%, 90% men, mean age 58.4 ± 9.1 years) were randomized to a supervised 12-week cardiac rehabilitation programme of three weekly sessions of either AIT (90–95% of peak heart rate (HR)) or ACT (70–75% of peak HR) on a bicycle. Primary outcome was peak VO2; secondary outcomes were peripheral endothelial function, cardiovascular risk factors, quality of life and safety. Results Peak VO2 (ml/kg/min) increased significantly in both groups (AIT 22.7 ± 17.6% versus ACT 20.3 ± 15.3%; p-time < 0.001). In addition, flow-mediated dilation (AIT +34.1% (range –69.8 to 646%) versus ACT +7.14% (range –66.7 to 503%); p-time < 0.001) quality of life and some other cardiovascular risk factors including resting diastolic blood pressure and HDL-C improved significantly after training. Improvements were equal for both training interventions. Conclusions Contrary to earlier smaller trials, we observed similar improvements in exercise capacity and peripheral endothelial function following AIT and ACT in a large population of CAD patients.KeywordsExercise intensity, Training modality, Coronary artery disease, Secondary preventionCardiac rehabilitationEndothelial function

Published
2015

33. Prediction model to estimate presence of coronary artery disease: Retrospective pooled analysis of existing cohorts

Author

Genders, T.S.S. (Tessa), Steyerberg, E.W. (Ewout), Hunink, M.G.M. (Myriam), Nieman, K. (Koen), Galema, T.W. (Tjebbe), Mollet, N.R.A. (Nico), Feyter, P.J. (Pim) de, Krestin, G.P. (Gabriel), Alkadhi, H. (Hatem), Leschka, S. (Sebastian), Desbiolles, L. (Lotus), Meijs, M.F.L. (Matthijs), Cramer, M.-J. (Maarten-Jan), Knuuti, J. (Juhani), Kajander, S. (Sami), Bogaert, J. (Jan), Goetschalckx, K. (Kaatje), Cademartiri, F. (Filippo), Maffei, E. (Erica), Martini, C. (Chiara), Seitun, S. (Sara), Aldrovandi, A. (Annachiara), Wildermuth, S. (Simon), Stinn, B. (Björn), Fornaro, J. (Jürgen), Feuchtner, G.M. (Gudrun), Zordo, T. (Tobias) de, Auer, T. (Thomas), Plank, F. (Fabian), Friedrich, G. (Guy), Pugliese, F. (Francesca), Petersen, S.E. (Steffen), Davies, L.C. (L. Ceri), Schoepf, U.J. (Joseph), Rowe, G.W. (Garrett W.), Mieghem, C.A.G. (Carlos) van, Driessche, L. (Luc) van, Sinitsyn, V. (Valentin), Gopalan, D. (Deepa), Nikolaou, K. (Konstantin), Bamberg, F. (Fabian), Cury, R.C. (Ricardo), Battle, J. (Juan), Maurovich-Horvat, P. (Pal), Bartykowszki, A. (Andrea), Merkely, B. (Bela), Becker, D. (Dávid), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Dewey, T.M. (Todd M.), Zimmermann, E. (Elke), Laule, M. (Michael), Genders, T.S.S. (Tessa), Steyerberg, E.W. (Ewout), Hunink, M.G.M. (Myriam), Nieman, K. (Koen), Galema, T.W. (Tjebbe), Mollet, N.R.A. (Nico), Feyter, P.J. (Pim) de, Krestin, G.P. (Gabriel), Alkadhi, H. (Hatem), Leschka, S. (Sebastian), Desbiolles, L. (Lotus), Meijs, M.F.L. (Matthijs), Cramer, M.-J. (Maarten-Jan), Knuuti, J. (Juhani), Kajander, S. (Sami), Bogaert, J. (Jan), Goetschalckx, K. (Kaatje), Cademartiri, F. (Filippo), Maffei, E. (Erica), Martini, C. (Chiara), Seitun, S. (Sara), Aldrovandi, A. (Annachiara), Wildermuth, S. (Simon), Stinn, B. (Björn), Fornaro, J. (Jürgen), Feuchtner, G.M. (Gudrun), Zordo, T. (Tobias) de, Auer, T. (Thomas), Plank, F. (Fabian), Friedrich, G. (Guy), Pugliese, F. (Francesca), Petersen, S.E. (Steffen), Davies, L.C. (L. Ceri), Schoepf, U.J. (Joseph), Rowe, G.W. (Garrett W.), Mieghem, C.A.G. (Carlos) van, Driessche, L. (Luc) van, Sinitsyn, V. (Valentin), Gopalan, D. (Deepa), Nikolaou, K. (Konstantin), Bamberg, F. (Fabian), Cury, R.C. (Ricardo), Battle, J. (Juan), Maurovich-Horvat, P. (Pal), Bartykowszki, A. (Andrea), Merkely, B. (Bela), Becker, D. (Dávid), Hadamitzky, M. (Martin), Hausleiter, J. (Jörg), Dewey, T.M. (Todd M.), Zimmermann, E. (Elke), and Laule, M. (Michael)

Published
2012
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34. Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts

Author

Genders, Tessa, Steyerberg, Ewout, Nieman, Koen, Galema, Tjebbe, Mollet, Nico, Feijter, Pim, Krestin, Gabriel, Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J, Goetschalckx, K, Cademartiri, F., Maffei, E, Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B, Fornaro, J, Feuchtner, G, De Zordo, T, Auer, T, Plank, F, Friedrich, G, Pugliese, F, Petersen, SE, Davies, LC, Schoepf, UJ, Rowe, GW, van Mieghem, CAG, van Driessche, L, Sinitsyn, V, Gopalan, D (Deepa), Nikolaou, K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B, Becker, D, Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E, Laule, M, Hunink, Myriam, Genders, Tessa, Steyerberg, Ewout, Nieman, Koen, Galema, Tjebbe, Mollet, Nico, Feijter, Pim, Krestin, Gabriel, Alkadhi, H, Leschka, S, Desbiolles, L, Meijs, MFL, Cramer, MJ, Knuuti, J, Kajander, S, Bogaert, J, Goetschalckx, K, Cademartiri, F., Maffei, E, Martini, C, Seitun, S, Aldrovandi, A, Wildermuth, S, Stinn, B, Fornaro, J, Feuchtner, G, De Zordo, T, Auer, T, Plank, F, Friedrich, G, Pugliese, F, Petersen, SE, Davies, LC, Schoepf, UJ, Rowe, GW, van Mieghem, CAG, van Driessche, L, Sinitsyn, V, Gopalan, D (Deepa), Nikolaou, K, Bamberg, F, Cury, RC, Battle, J, Maurovich-Horvat, P, Bartykowszki, A, Merkely, B, Becker, D, Hadamitzky, M, Hausleiter, J, Dewey, M, Zimmermann, E, Laule, M, and Hunink, Myriam

Abstract

Objectives To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations. Design Retrospective pooled analysis of individual patient data. Setting 18 hospitals in Europe and the United States. Participants Patients with stable chest pain without evidence for previous coronary artery disease, if they were referred for computed tomography (CT) based coronary angiography or catheter based coronary angiography (indicated as low and high prevalence settings, respectively). Main outcome measures Obstructive coronary artery disease (>= 50% diameter stenosis in at least one vessel found on catheter based coronary angiography). Multiple imputation accounted for missing predictors and outcomes, exploiting strong correlation between the two angiography procedures. Predictive models included a basic model (age, sex, symptoms, and setting), clinical model (basic model factors and diabetes, hypertension, dyslipidaemia, and smoking), and extended model (clinical model facto Results We included 5677 patients (3283 men, 2394 women), of whom 1634 had obstructive coronary artery disease found on catheter based coronary angiography. All potential predictors were significantly associated with the presence of disease in univariable and multivariable analyses. The clinical model improved the prediction, compared with the basic model (cross validated c statistic improvement from 0.77 to 0.79, net reclassification improvement 35%); the coronary calcium score in the extended Conclusions Updated prediction models including age, sex, symptoms, and cardiovascular risk factors allow for accurate estimation of the pretest probability of coronary artery disease in low prevalence populations. Addition of coronary calcium scores to the prediction models improves the estimates.

Published
2012

35. A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension

Author

Genders, T S S, Steyerberg, E W, Alkadhi, H, Leschka, S, Desbiolles, L, Nieman, K, Galema, T W, Meijboom, W B, Mollet, N R, de Feyter, P J, Cademartiri, F, Maffei, E, Dewey, M, Zimmermann, E, Laule, M, Pugliese, F, Barbagallo, R, Sinitsyn, V, Bogaert, J, Goetschalckx, K, Rowe, G W, Schoepf, U J, Schuijf, J D, Bax, J J, de Graaf, F R, Knuuti, J, Kajander, S, van Mieghem, C A G, Meijs, M F L, Cramer, M J, Gopalan, D, Feuchtner, G, Friedrich, G, Krestin, G P, Hunink, M G M, Genders, T S S, Steyerberg, E W, Alkadhi, H, Leschka, S, Desbiolles, L, Nieman, K, Galema, T W, Meijboom, W B, Mollet, N R, de Feyter, P J, Cademartiri, F, Maffei, E, Dewey, M, Zimmermann, E, Laule, M, Pugliese, F, Barbagallo, R, Sinitsyn, V, Bogaert, J, Goetschalckx, K, Rowe, G W, Schoepf, U J, Schuijf, J D, Bax, J J, de Graaf, F R, Knuuti, J, Kajander, S, van Mieghem, C A G, Meijs, M F L, Cramer, M J, Gopalan, D, Feuchtner, G, Friedrich, G, Krestin, G P, and Hunink, M G M

Abstract

Aims The aim was to validate, update, and extend the Diamond-Forrester model for estimating the probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Methods and results Prospectively collected data from 14 hospitals on patients with chest pain without a history of CAD and referred for conventional coronary angiography (CCA) were used. Primary outcome was obstructive CAD, defined as ≥50% stenosis in one or more vessels on CCA. The validity of the Diamond-Forrester model was assessed using calibration plots, calibration-in-the-large, and recalibration in logistic regression. The model was subsequently updated and extended by revising the predictive value of age, sex, and type of chest pain. Diagnostic performance was assessed by calculating the area under the receiver operating characteristic curve (c-statistic) and reclassification was determined. We included 2260 patients, of whom 1319 had obstructive CAD on CCA. Validation demonstrated an overestimation of the CAD probability, especially in women. The updated and extended models demonstrated a c-statistic of 0.79 (95% CI 0.77-0.81) and 0.82 (95% CI 0.80-0.84), respectively. Sixteen per cent of men and 64% of women were correctly reclassified. The predicted probability of obstructive CAD ranged from 10% for 50-year-old females with non-specific chest pain to 91% for 80-year-old males with typical chest pain. Predictions varied across hospitals due to differences in disease prevalence. Conclusion Our results suggest that the Diamond-Forrester model overestimates the probability of CAD especially in women. We updated the predictive effects of age, sex, type of chest pain, and hospital setting which improved model performance and we extended it to include patients of 70 years and older.

Published
2011

41. Prediction model to estimate presence of coronary artery disease: retrospective pooled analysis of existing cohorts

Author

Genders, T. S. S., primary, Steyerberg, E. W., additional, Hunink, M. G. M., additional, Nieman, K., additional, Galema, T. W., additional, Mollet, N. R., additional, Feyter, P. J. d., additional, Krestin, G. P., additional, Alkadhi, H., additional, Leschka, S., additional, Desbiolles, L., additional, Meijs, M. F. L., additional, Cramer, M. J., additional, Knuuti, J., additional, Kajander, S., additional, Bogaert, J., additional, Goetschalckx, K., additional, Cademartiri, F., additional, Maffei, E., additional, Martini, C., additional, Seitun, S., additional, Aldrovandi, A., additional, Wildermuth, S., additional, Stinn, B., additional, Fornaro, J., additional, Feuchtner, G., additional, De Zordo, T., additional, Auer, T., additional, Plank, F., additional, Friedrich, G., additional, Pugliese, F., additional, Petersen, S. E., additional, Davies, L. C., additional, Schoepf, U. J., additional, Rowe, G. W., additional, van Mieghem, C. A. G., additional, van Driessche, L., additional, Sinitsyn, V., additional, Gopalan, D., additional, Nikolaou, K., additional, Bamberg, F., additional, Cury, R. C., additional, Battle, J., additional, Maurovich-Horvat, P., additional, Bartykowszki, A., additional, Merkely, B., additional, Becker, D., additional, Hadamitzky, M., additional, Hausleiter, J., additional, Dewey, M., additional, Zimmermann, E., additional, and Laule, M., additional

Published
2012
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50. A clinical prediction rule for the diagnosis of coronary artery disease: validation, updating, and extension

Author

Genders, T S S, Steyerberg, E W, Alkadhi, H, Leschka, S, Desbiolles, L, Nieman, K, Galema, T W, Meijboom, W B, Mollet, N R, de Feyter, P J, Cademartiri, F, Maffei, E, Dewey, M, Zimmermann, E, Laule, M, Pugliese, F, Barbagallo, R, Sinitsyn, V, Bogaert, J, Goetschalckx, K, Rowe, G W, Schoepf, U J, Schuijf, J D, Bax, J J, de Graaf, F R, Knuuti, J, Kajander, S, van Mieghem, C A G, Meijs, M F L, Cramer, M J, Gopalan, D, Feuchtner, G, Friedrich, G, Krestin, G P, and Hunink, M G M

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