Search

The relevance of the study is determined by the fact that the increasingly dynamic and competitive nature of the market requires companies to provide high quality logistics services, especially in the field of medical equipment. The purpose of the study is to analyze and identify key factors influencing the efficiency of medical equipment logistics. Among the methods used were analytical method, statistical method, functional method, system analysis method, deductive method, synthesis method and comparative method. During the research, the logistics system was analyzed. The study summarizes current trends and provides practical recommendations. The practical significance of the results is to improve logistics processes and improve the quality of services.

The Russian Federation includes 89 regions in which, in accordance with climate and environmental factors, the predisposition of the population to various types of diseases is revealed. A measure to prevent these diseases is the development of biologically active additives, functional and specialized food products. The problem of morbidity of one of the regions of the Russian Federation was studied. This was based on the example of the population of the Orel region where the greatest increase in diseases of the digestive system was detected. The legislative framework of the Russian Federation allows for the production of functional products, but the lack of economic incentives for food industry enterprises and trade organizations does not contribute to the promotion of existing developments and formulations of such products in the consumer market. It is proposed at regional level to reduce the tax rate on functional food products and reduce selling prices. It is recommended to the enterprises of the food and processing industry to enrich food products with biologically active additives. To create scientific and technological centers with the involvement of health authorities, food and processing industry and trade enterprises to develop functional and specialized food products and bring them to consumers.

It is increasingly understood that the epilepsies are characterized by network pathology that can span multiple spatial and temporal scales. Recent work indicates that infraslow (<0.2 Hz) envelope correlations may form a basis for distant spatial coupling in the brain. We speculated that infraslow correlation structure may be preserved even with some time lag between signals. To this end, we studied intracranial EEG (icEEG) data collected from 22 medically refractory epilepsy patients. For each patient, we selected hour-long background, awake icEEG epochs before and after antiseizure medication (ASM) taper. For each epoch, we selected 5,000 random electrode contact pairs and estimated magnitude-squared coherence (MSC) below 0.15 Hz of band power timeseries in the traditional EEG frequency bands. Using these same contact pairs, we shifted one signal of the pair by random durations in 15-s increments between 0 and 300 s. We aggregated these data across all patients to determine how infraslow MSC varies with duration of lag. We further examined the effect of ASM taper on infraslow correlation structure. We also used surrogate data to empirically characterize MSC estimator and to set optimal parameters for estimation specifically for the study of infraslow activity. Our empirical analysis of the MSC estimator showed that hour-long segments with MSC computed using 3-min windows with 50% overlap was sufficient to capture infraslow envelope correlations while minimizing estimator bias and variance. The mean MSC decreased monotonically with increasing time lag until 105 s of lag, then plateaued between 106 and 300 s. Significantly nonzero infraslow envelope MSC was preserved in all frequency bands until about 1 min of time lag, both pre- and post-ASM taper. We also saw a slight, but significant increase in infraslow MSC post-ASM taper, consistent with prior work. These results provide evidence for the feasibility of examining infraslow activity via its modulation of higherfrequency activity in the absence of DC-coupled recordings. The use of surrogate data also provides a general methodology for benchmarking measures used in network neuroscience studies. Finally, our study points to the clinical relevance of infraslow activity in assessing seizure risk. [ABSTRACT FROM AUTHOR]

This concept addresses the main economic, environmental, scientific and technological issues associated with the use of homogeneous Pt‐catalysts in the important industrial hydrosilylation process. The development of biphase catalysis is proposed as the most promising approach. One solution we suggest is the use of ethylene glycol (EG) as a medium in biphase catalysis. We have previously shown that EG in Pt‐catalyzed hydrosilylation serves not only as a medium but also as a mild reducing agent of Pt‐ions to Pt0, as well as an effective ligand for the preparation of mononuclear Pt01‐complexes. These zero valent platinum complexes are single‐atom catalysts (SAC) and have high activity in hydrosilylation, stability during storage and the ability to be recycled multiple times (~40 times). This option of using an atomic catalyst allows us to combine the advantages of homogeneous and heterogeneous catalysts. [ABSTRACT FROM AUTHOR]

Nonsyndromic sporadic thoracic aortic aneurysm (nssTAA) is characterized by diverse genetic variants that may vary in different populations. Our aim was to identify clinically relevant variants in genes implicated in hereditary aneurysms in Russian patients with nssTAA. Forty-one patients with nssTAA without dissection were analyzed. Using massive parallel sequencing, we searched for variants in exons of 53 known disease-causing genes. Patients were found to have no (likely) pathogenic variants in the genes of hereditary TAA. Six variants of uncertain significance (VUSs) were identified in four (9.8%) patients. Three VUSs [FBN1 c.7841C>T (p.Ala2614Val), COL3A1 c.2498A>T (p.Lys833Ile), and MYH11 c.4993C>T (p.Arg1665Cys)] are located in genes with "definitive" disease association (ClinGen). The remaining variants are in "potentially diagnostic" genes or genes with experimental evidence of disease association [NOTCH1 c.964G>A (p.Val322Met), COL4A5 c.953C>G (p.Pro318Arg), and PLOD3 c.833G>A (p.Gly278Asp)]. Russian patients with nssTAA without dissection examined in this study have ≥1 VUSs in six known genes of hereditary TAA (FBN1, COL3A1, MYH11, NOTCH1, COL4A5, or PLOD3). Experimental studies expanded genetic testing, and clinical examination of patients and first/second-degree relatives may shift VUSs to the pathogenic (benign) category or to a new class of rare "predisposing" low-penetrance variants causing the pathology if combined with other risk factors. [ABSTRACT FROM AUTHOR]

Research on the Sustainable Supply Chain is a significant focus within the academic community, highlighting the importance of smart logistics, smart transportation, and digital technologies. This paper reviews current research trends from 2014 to 2023 by analyzing publications from the Web of Science database. The bibliometric analysis covers publication counts, document types, top-cited papers, leading journals, main funding sponsors, and distribution by subject categories, countries, and institutions. Additionally, co-authorship and keyword co-occurrence were examined to identify key knowledge components and research clusters. The analysis underscores the need for expanded international research and continuous integration of Sustainable Supply Chain concepts for future development. The goal of the document is to provide a comprehensive review of research and industrial trends and key insights in the fields of smart logistics, smart transportation, and digital technologies in recent years. [ABSTRACT FROM AUTHOR]

Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARD8); comorbidity between asthma and hypertension was found to be associated with rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is different from genetic backgrounds of both diseases manifesting isolated.

Analysis of the history of the pates creation has shown significant prospects of the product at the present time. Model samples of meat and vegetable pates have been developed by introducing a mixture of powders from rosehip and nettle leaves in an amount of 5, 8 and 10% and a cereal filler made from oatmeal. In terms of organoleptic quality indicators, the sample with the addition of 8% of a mixture of meal powders turned out to be the best. The technological process of the production of meat-vegetable pates includes both traditional operations and the preparation and introduction of herbal ingredients. The developed pate samples were stored at a temperature of 4 ± 2˚C for 7 days, and the quality indicators were assessed. The pastes “Young Strength” and “Willpower and Strength of Mind” are the best. Their highest score is 4.96. It has been established that the consumption of 100 g of “Powerful Strength” pate will provide the daily requirement of men and women of elderly and old age in vitamin B6 by 25.3%, iron by 28.1 and 15.6% (respectively). “Willpower and Strength of Mind” will cover the satisfaction of the daily need for vitamin B6 by 17.8% of men and women of the elderly and old age, in iron by 22.9% for men. And with the use of “ Young Strength “pate the daily need of older people for vitamin B6 will be satisfied for 17.8%, in iron by 20.8% in men of this age category. The use of meat-containing non-meat components with high nutritional value in pate technologies allows us to class them as functional products.

The production of dialkyl ethers is based on the interaction of alcohols with iso-olefins, which have limited resources nowadays. In the meantime, Russian oil refineries have a huge resource potential for thermal gasoline having high content of unsaturated compounds. Highly unsaturated hydrocarbon fractions are characterized by low chemical stability. Their addition to commercial fuels deteriorates its properties, further processing causes rapid poisoning of the catalyst, as a result, they are not used commercially in industry. However, they present potentially valuable feedstock for the synthesis of oxygen-containing components of motor fuels - dialkyl ethers, which improve their environmental and operational properties. Current research is devoted to study the possibility of synthesizing of dialkyl ethers via interaction of normal olefins with ethyl alcohol. The results obtained confirm the possibility of the formation of dialkyl ethers based on normal olefins. [ABSTRACT FROM AUTHOR]