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1. Pneumonia

Author

Howie, Stephen R.C., primary, Hamer, Davidson H., additional, Langridge, Fiona C., additional, McCollum, Eric D., additional, and Graham, Stephen M., additional

Published
2024
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3. Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies

Author

Martinez, Leonardo, Seddon, James, Liu, Qiao, Acuna Villaorduna, Carlos, Bonnet, Maryline, Carvalho, Anna Cristina C., Chan, Pei-Chun, Hill, Philip C, Lopez-Varela, Elisa, Donkor, Simon, Graham, Stephen M., Villalba, Julian A., Grandjean, Louis, Zellweger, Jean-Pierre, Wang, Jann-Yuan, Verhagen, Lilly M, van Schalkwykn, Cari, van der Loeff, Maarten F Schim, Sloot, Rosa, Trieu, Lisa, Ahuja, Shama Desai, Yoshiyama, Takashi, Mazahir, Rufaida, Martinsonn, Neil A, Jones-López, Edward C., Altet, Neus, Kato, Seiya, Fang, Chi-Tai, Geis, Steffen, Hauri, Anja, Long, Richard, Dobler, Claudia C, Cayla, Joan A, Chakhaia, Tsira, Chen, Cheng, García-Basteiro, Alberto L., Triasih, Rina, Huang, Li-Min, Sharma, Surendra, Hannoun, Djohar, Malone, LaShaunda L., Ling, Du-Lin, Kritski, Afrânio, Stein, Catherine M., Malik, Amyn A, Augusto, Orvalho, Vashishtha, Richa, Boulahbal, Fadila, Boom, W. Henry, Shen, Ye, Hesseling, Anneke C, Horsburgh, C. Robert, Lange, Christoph, Mandalakas, Anna M., Seddon, James A, Horsburgh, C Robert, and Mandalakas, Anna M

Published
2024
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5. Diagnostic accuracy of a three-gene Mycobacterium tuberculosis host response cartridge using fingerstick blood for childhood tuberculosis: a multicentre prospective study in low-income and middle-income countries

Author

Baard, Cynthia Biddle, Munro, Jacinta Diane, Prins, Margaretha, Benzi, Nolufefe, Bateman, Linda Claire, Ryan, Ashleigh, Booi, Kutala, Paulo, Nezisa, Heydenrych, Anthenette, Petersen, Wonita, Brookes, Raquel, Mento, Michele, Centner, Chad, Dalgarno, Craig, Rieß, Friedrich, Mutuku, Sarah, Saathoff, Elmar, Held, Kathrin, Ninan, Marilyn Mary, Chacko, Anila, Kumari, Ramya, Dhanabhagyam, R, Muniswamy, Nithya, Nicol, Marc P, Mtafya, Bariki, Mwambola, Harieth, Manyama, Christina, Mahiga, Hellen, Sichone, Emanuel, Sudi, Lwitiho, Maueia, Cremildo, Madeira, Carla, Cambuie, Justina, Ribeiro, Jorge, Chiume, Lingstone, Mnyanga, Alice, Sikwese, Tionge, Masakasa, Happy, Kachere, Diana, Kosaka, Masheck, Niemann, Stefan, Chegou, Novel, Horn, Lyn, Olbrich, Laura, Verghese, Valsan P, Franckling-Smith, Zoe, Sabi, Issa, Ntinginya, Nyanda E, Mfinanga, Alfred, Banze, Denise, Viegas, Sofia, Khosa, Celso, Semphere, Robina, Nliwasa, Marriott, McHugh, Timothy D, Larsson, Leyla, Razid, Alia, Song, Rinn, Corbett, Elizabeth L, Nabeta, Pamela, Trollip, Andre, Graham, Stephen M, Hoelscher, Michael, Geldmacher, Christof, Zar, Heather J, Michael, Joy Sarojini, and Heinrich, Norbert

Published
2024
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6. Effectiveness of a community-based approach for the investigation and management of children with household tuberculosis contact in Cameroon and Uganda: a cluster-randomised trial

Author

Chauvet, Savine, de Carvalho, Elisabete, Ouedraogo, Sayouba, Leguicher, Gwenvael, Tiam, Appolinaire, Oziemkowska, Maria, Atieno Ayuo, Elizabeth, Mafirakureva, Nyashadzaishe, Berset, Maude, Lemaire, Jean-Francois, Sih, Collette, Kana, Rogacien, Youm, Eric, Guedem Nekame, Jinette Lorraine, Manguele, Paul Williams, Bindzi, Paul, Ndongo, Marie-Louise Aimée, Ndjang Kombou, Doline, Tsigaing, Philippe Narcisse, Mbunka Awolu, Muhamed, Seuleu Ndjamakou, Leticia Grace, Sitamze Kaptue, Narcisse, Ngounou Moyo, Dany Flora, Patouokoumche Ngouh, Raimatou, Kouotou Mouliom, Joseph Stéphane, Abogo Abatsong, Henriette Alida, Essebe Ngangue, Rose Cynthia, Djeumene, Rodrigue, Maguia Tatiane Kouam, Laure Tatiane, Nono Djilo, Lydie Flore, Bakmano Raïssa, Marie-Josée, Njikeh, Kong Derick, Bissek, Anne-Cécile, Arinaitwe, Rinah, Otai, David, Kamanzi, Hamidah, Natukunda, Agnes, Natukunda, Eva, Kyarimpa, Rose, Kyomuhendo, Doreen, Sanyu, Scovia, Ssemanya, John, Nabbuto, Jane, Lugoose, Ssuan, Rachael, Kiconco, Tebylwa Beryta, Jonanita, Kitakule, Frank, Atuhaire, Syson, Kembabazi, Moreen, Abok, Florence, Kakinda, Michael, Odongo, Dickens, Ijjo, Henri, Kyomugisha, Clemencia, Aryatuhwera, Johnan, Ashaba, Beth, Nuwamanya, Patrick, Arinaitwe, Merdard, Natukunda, Prisca, Muhangi, Collins, Muhumuza, Deogratious, Ndyeimuka, Gordon, Bagabe, Johnson, Tiboruhanga, Justus, Tibaijuka, Francis, Nahabwe, Marion, Bonnet, Maryline, Vasiliu, Anca, Tchounga, Boris K, Cuer, Benjamin, Fielding, Katherine, Ssekyanzi, Bob, Tchakounte Youngui, Boris, Cohn, Jennifer, Dodd, Peter J, Tiendrebeogo, Georges, Tchendjou, Patrice, Simo, Leonie, Okello, Richard F, Kuate Kuate, Albert, Turyahabwe, Stavia, Atwine, Daniel, Graham, Stephen M, and Casenghi, Martina

Published
2023
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7. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis

Author

Martinez, Leonardo, Cords, Olivia, Horsburgh, C Robert, Andrews, Jason R, Consortium, Pediatric TB Contact Studies, Acuna-Villaorduna, Carlos, Ahuja, Shama Desai, Altet, Neus, Augusto, Orvalho, Baliashvili, Davit, Basu, Sanjay, Becerra, Mercedes, Bonnet, Maryline, Boom, W Henry, Borgdorff, Martien, Boulahbal, Fadila, Carvalho, Anna Cristina C, Cayla, Joan A, Chakhaia, Tsira, Chan, Pei-Chun, Cohen, Ted, Croda, Julio, Datta, Sumona, del Corral, Helena, Denholm, Justin T, Dietze, Reynaldo, Dobler, Claudia C, Donkor, Simon, Egere, Uzochukwu, Ellner, Jerrold J, Espinal, Marcos, Evans, Carlton A, Fang, Chi-Tai, Fielding, Katherine, Fox, Greg J, García, Luis F, García-Basteiro, Alberto L, Geis, Steffen, Graham, Stephen M, Grandjean, Louis, Hannoun, Djohar, Hatherill, Mark, Hauri, Anja M, Hesseling, Anneke C, Hill, Philip C, Huang, Li-Min, Huerga, Helena, Hussain, Rabia, Jarlsberg, Leah, Jones-López, Edward C, Kato, Seiya, Kato-Maeda, Midori, Kampmann, Beate, Kirchner, H Lester, Kritski, Afrânio, Lange, Christoph, Lee, Chih-Hsin, Lee, Li-Na, Lee, Meng-Rui, Lemos, Antonio Carlos, Lienhardt, Christian, Ling, Du-Lin, Liu, Qiao, Lo, Nathan C, Long, Richard, Lopez-Varela, Elisa, Lu, Peng, Magee, Matthew, Malone, LaShaunda L, Mandalakas, Anna M, Martinson, Neil A, Mazahir, Rufaida, Murray, Megan B, Netto, Eduardo Martins, Otero, Larissa, Parsonnet, Julie, Reingold, Arthur, Schaaf, H Simon, Seddon, James A, Sharma, Surendra, Singh, Jitendra, Singh, Sarman, Sloot, Rosa, Sotgiu, Giovanni, Stein, Catherine M, Iqbal, Najeeha Talat, Triasih, Rina, Trieu, Lisa, van der Loeff, Maarten F Schim, Van der Stuyft, Patrick, van Schalkwyk, Cari, Vashishtha, Richa, Verhagen, Lilly M, Villalba, Julian A, Wang, Jann-Yuan, Whalen, Christopher C, Yoshiyama, Takashi, Zar, Heather J, Zellweger, Jean-Pierre, and Zhu, Limei

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Tuberculosis, Prevention, Rare Diseases, Pediatric, Infectious Diseases, Emerging Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Age Factors, Child, Child, Preschool, Contact Tracing, Disease Transmission, Infectious, Family Characteristics, Female, Global Health, Humans, Incidence, Male, Mycobacterium tuberculosis, Risk Assessment, Sex Factors, Tuberculosis, Pulmonary, Pediatric TB Contact Studies Consortium, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundTens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood.MethodsIn this systematic review and meta-analysis, we investigated the development of tuberculosis in children closely exposed to a tuberculosis case and followed for incident disease. We restricted our search to cohort studies published between Jan 1, 1998, and April 6, 2018, in MEDLINE, Web of Science, BIOSIS, and Embase electronic databases. Individual-participant data and a pre-specified list of variables were requested from authors of all eligible studies. These included characteristics of the exposed child, the index case, and environmental characteristics. To be eligible for inclusion in the final analysis, a dataset needed to include: (1) individuals below 19 years of age; (2) follow-up for tuberculosis for a minimum of 6 months; (3) individuals with household or close exposure to an individual with tuberculosis; (4) information on the age and sex of the child; and (5) start and end follow-up dates. Studies assessing incident tuberculosis but without dates or time of follow-up were excluded. Our analysis had two primary aims: (1) estimating the risk of developing tuberculosis by time-period of follow-up, demographics (age, region), and clinical attributes (HIV, tuberculosis infection status, previous tuberculosis); and (2) estimating the effectiveness of preventive therapy and BCG vaccination on the risk of developing tuberculosis. We estimated the odds of prevalent tuberculosis with mixed-effects logistic models and estimated adjusted hazard ratios (HRs) for incident tuberculosis with mixed-effects Poisson regression models. The effectiveness of preventive therapy against incident tuberculosis was estimated through propensity score matching. The study protocol is registered with PROSPERO (CRD42018087022).FindingsIn total, study groups from 46 cohort studies in 34 countries-29 (63%) prospective studies and 17 (37%) retrospective-agreed to share their data and were included in the final analysis. 137 647 tuberculosis-exposed children were evaluated at baseline and 130 512 children were followed for 429 538 person-years, during which 1299 prevalent and 999 incident tuberculosis cases were diagnosed. Children not receiving preventive therapy with a positive result for tuberculosis infection had significantly higher 2-year cumulative tuberculosis incidence than children with a negative result for tuberculosis infection, and this incidence was greatest among children below 5 years of age (19·0% [95% CI 8·4-37·4]). The effectiveness of preventive therapy was 63% (adjusted HR 0·37 [95% CI 0·30-0·47]) among all exposed children, and 91% (adjusted HR 0·09 [0·05-0·15]) among those with a positive result for tuberculosis infection. Among all children

Published
2020

8. Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia

Author

Laemmle-Ruff, Ingrid, Graham, Stephen M., Williams, Bridget, Horyniak, Danielle, Majumdar, Suman S., Paxton, Georgia A., Caplice, Lila V. Soares, Hellard, Margaret E., and Trauer, James M.

Subjects
Tuberculosis -- Diagnosis -- Risk factors -- Statistics, Communicable diseases in children -- Diagnosis -- Risk factors -- Statistics, Pediatric research, Health
Abstract

Tuberculosis (TB) is a leading contributor to the burden of infectious disease worldwide, causing >1.2 million deaths in 2019 (1,2). Latent tuberculosis infection (LTBI), defined as infection with Mycobacterium tuberculosis [...]

Published
2022
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9. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, Serre, Angeline, Badrichani, Anne, Razafimanantsoa, Manoa, Poublan, Julien, Vessière, Aurélia, Roucher, Clémentine, Occelli, Estelle, Beuscart, Aurélie, Charpin, Aurélie, Habiyambere, Gemma, Mesnier, Salomé, Balestre, Eric, Bhatta, Bandana, Maillard, Anne-Laure, Orne-Gliemann, Joanna, Baillet, Emmanuelle, Koskas, Nicolas, D'Elbée, Marc, Gabillard, Delphine, Font, Hélène, Huyen, Minh, Bonnet, Maryline, Lounnas, Manon, Espérou, Hélène, Couffin-Cadiergues, Sandrine, Kuppers, Alexis, Hamze, Benjamin, BORAND, Laurence, de LAUZANNE, Agathe, DIM, Bunnet, Keang, Chanthy, PRING, Long, YIN, Song, SARITH, Channimol, PHAN, Chanvirak, NHEUONG, Sovann, LY, Socheat, KAING, Sanary, SRENG, Vouchleang, LUN, Elen, SAY, Leakhena, SUOM, Sophea, FERHY, Romyka, SO, Dina, BORN, Sorunna, PAL, Sophea, NANG, Boraneath, MAO, Tan Eang, KIM, Ang, Srey, Viso, Kan, Piseth, Hout, leakhena, Ith, Samnang, Oum, Sophany, Sau, Sokunvadhana, Ho, Kim Heang, Kith, Daronic, Nuch, Nathara, Horm, Chhun Leang, Sophon, Cheameas, Roeungdeth, Bosba, MENG, Chhay, RITH, Ravin, PHY, Samnang, SOR, Chanchetra, SAO, Voleak, KHAT, Sophea, MAK, Bunthoeun, UY, Angkeaborin, KHAY, Sreyny, SOM, Kimsan, HACH, rongvirak, SOK, Hay, KUON, Sotheavy, HENG, Synatt, SENG, Amara, NIM, Sopheak, PAN, Reach, KIM, Srean, SREY LEAP, Keo, NET, Bormey, NOUN, Viccheka, LAY, Daven, MANY, Chhaing, Seng, Socheata, Ly, Vuthy, So, Saran, Oun, Sovutthik, CHEY, Sopheap, CHHEA, Rattany, BAONG, Lydeth, THOUNG, Vanna, KHEANG, Chanrithea, BY, Borady, Nguon, Vathanak, MEACH, Eksophea, Tek, Sopheak, Ngeav, Sina, Lun, Tetra, HEM, Deth, CHUT, Nayreang, SARIK, Setha, NANG, Hgekkoung, MEACH, Mengnean, SRENG, Sopal, SAR, Dara, KIN, Rathana, ROS, Phoran, DORN, Chenda, KAK, Chansy, Sambath, Srey Leak, Son, Leakhena, Bin, Linda, Pengong, Eangnay, Pol, Sokha, Khutsorn, Samnang, Seang, Sorsophea, Soun, Virak, Vong, Vuthy, Khoeung, Chandara, Um, Panha, Bou, Sokunthea, Song Pich, Sarin, Nim, Puthy, Khat, Sopheak, Ban Si, Nuon, Ream, Sovannodom, Ing, Sim, Chann, Phanith, Ngeth, Samrith, Sun, Marina, Chhoeung, Sokea, Sean, Soeun, Prak, Ratanak, Taguebue, Jean-Voisin, Kwedi Nolna, Sylvie, Amboua Schouame Onambele, Audrey, Hycenth, Numfor, Melingui, Bernard, Nkembe Medounmga, Angeline, Hougnang Tatmi, Luciole, Etemgoua, Nathalie, Kouesso, Vanessa, Bugin, Jean, Nzedjom, Celestine, Ngoya, Roger, Eyike, Jules, Loudjom, Elyse, Lonsti, Roger, Dang, Ladi, Bintar, Edward, Njayong, Chantal, Ngonsoa O, Cinthia, Ndzeukap, Isabelle, Dzoyem, Pascaline, Dzokou, Clémentine, Dindo, Berthe, Moh, Raoul, Komena, Eric Auguste, Aka Bony, Roger, Kouadio, Christian, Danho, Serge, Goli, Melissa, Folquet, Madeleine, Itchy, Max Valère, Sidibé, Abdel, Cissé, Lancina, Ouattara, Joseph, Konaté, Mamadou, Amon-Tanoh Dick, Flore, Cardena, Melissa, Adonis-Koffi, Laurence, Eugenie, Djabia, Kouamé, Ferdinand, Menan, Hervé, Inwoley, André, Ouassa, Timothée, Nguessan, Marcelle Sandrine, Khosa, Celso, Cumbe, Saniata, Manhiça, Emelva, Zitha, Alcina, Chiúle, Valter, Muxanga, Eva, Gune, Irene, Lima, Yara, Ribeiro, Jorge, Mavale, Sandra, Chilundo, Josina, Maxanguana, Felismina, Morais, Natália, Manhiça, Julieta, Give, Josefina, Atumane, Jafito, Lucas, Gelson, Thai, Arsénio, Chave, Adélio, Rego, Dalila, Guambe, Lúcia, Issa, Faiaz, Carneiro, Rosa, Pene, Neusa, Florindo, Natércia, Machel, Dália, Cumbane, Cecília, Mendes, Helena, Kitungwa, Mule, Muianga, Valdo, Tamele, Humberto, Sulude, Adelino, Mabota, Roda, Comandante, Herquéria, Massangaie, Abelardo, Wobudeya, Eric, Businge, Gerald Bright, Namulinda, Faith, Sserunjogi, Robert, Nassozi, Rashidah, Barungi, Charlotte, Aanyu, Hellen, Muwonge, Doreen, Kagoya, Eva, Aciparu, Serene, Chemutai, Sophia, Ntambi, Samuel, Wasswa, Amir, Nangozi, Juliet, Tagoola, Abner, Mbekeka, Prossy, Kenneth, Sajja, Lubega, John Paul, Nassali, Aidah, Tagobera, Jessica, Agwang, Christine, Kalembe, Florence, Ajambo, Annet, Aguti, Elizabeth, Kasibante, Samuel, Matende, Henry, Odongo, Israel Owen, Mwanga Amumpaire, Juliet, Natukunda, Naome, Ngabirano, Gertrude, Kakwenza, Paul, Nuwamanya, Simpson, Nyangoma, Miria, Nabbuto, Jane, Abok, Florence, Arinaitwe, Rinah, Birungi, Diana, Mwesigwa, Evans, Atwine, Daniel, Mbega, Hassan, Orikiriza, Patrick, Taremwa, Ivan, Turyashemererwa, Esther, Derrick, Hope, Nyehangane, Dan, Kaitano, Rodney, Logoose, Susan, Businge, Steven, Ntambi, Charles, Mugabi, Jerome, Mzee, John, Besigye, Julius, Kanzira, Saul, Turyatemba, Phionah, Twebaze, Florence, Chabala, Chishala, Mulenga, Veronica, Shankalala, Perfect, Hambulo, Chimuka, Kapotwe, Vincent, Ngambi, Marjory, Kasakwa, Kunda, Chirwa, Uzima, Kapula, Chifunda, Zulu, Susan, Nawakwi, Grace, Siasulingana, Teddy, Chilonga, Jessy, Chimbini, Maria, Chilanga, Mutinta, Nduna, Bwendo, Inambao, Muleya, Mwambazi, Mwate, Halende, Barbra, Mumba, Wyclef, Mankunshe, Endreen, Silavwe, Maureen, Chakopo, Moses, Moono, Roy, Mwanga-Amumpaire, Juliet, De Lauzanne, Agathe, Dim, Bunnet, Tiogouo Ngouana, Emeline, Folquet Amorrissani, Madeleine, Cisse, Lassina, Amon Tanoh Dick, Flore, Komena, Eric A, Businge, Gerald, Kim, Ang, Kheang, Chanrithea, Maleche-Obimbo, Elizabeth, Seddon, James A, Mao, Tan Eang, Graham, Stephen M, Delacourt, Christophe, and Borand, Laurence

Published
2023
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10. Inadequate Lopinavir Concentrations With Modified 8-Hourly Lopinavir/Ritonavir 4: 1 Dosing During Rifampicin-based Tuberculosis Treatment in Children Living With HIV

Author

Chabala, Chishala, Turkova, Anna, Kapasa, Monica, LeBeau, Kristen, Tembo, Chimuka H., Zimba, Kevin, Weisner, Lubbe, Zyambo, Khozya, Choo, Louise, Chungu, Chalilwe, Lungu, Joyce, Mulenga, Veronica, Crook, Angela, Gibb, Diana, McIlleron, Helen, Gibb, Diana M., Turkova, Anna, Crook, Angela M., Choo, Louise, Wills, Genevieve, Thomason, Margaret J., Teera, Jaqueline, Owen- Powell, Ellen, LeBeau, Kristen, Baptiste, David, McGowan, Charlotte, Spyer, Moira, Chabala, Chishala, Mulenga, Veronica, Lungu, Joyce, Kapasa, Monica, Zimba, Kevin, Zyambo, Khozya, Chungu, Chalilwe, Tembo, Chimuka, Kunda, Sharon, Shingalili, Ellen, Zulu, Semy, Chipoya, Terence, Mwanakalanga, Habulembe, Chambela, Elias, Hankombo, Jessy M., Kalumbi, Mox Malama, Chola, Daniel, Malama, Stephen, Wobudeya, Eric, Musoke, Philippa, Baldwin, Mboizi Robert, Nansamba, Winnie, Ssenyonga, Mark, Ssengooba, Willy, Businge, Gerald, Hesseling, Anneke C., Palmer, Megan, van der Zalm, Marieke M., Workman, Jessica, Demers, Anne-Marie, Schaaf, Simon, Gie, Robert, Walters, Elisabetta, Zimri, Warren, Hoddinott, Graeme, Deventer, Anneen van, Goussard, Pierre, Morrison, Julie, Mave, Vidya, (PI), Kinikar, Aarti Avinash, Raichur, Priyanka, Nijampurkar, Aparna, Khan, Sameer, Hissar, Syed, Joseph, Bency, Bhavani, Perumal Kannabiran, Prathiksha, G, Baskaran, Dhanaraj, Gomathi, NS, Mythily, V, Kumar, Hemanth, Chelvi, Silambu, Sekar, L, Hanna, Luke, Ramesh, K, Latha, Hema, Bharathi, S, Banu, Parveen, Xavier, Dino, Kumar, Manjith, Guru, K, Kumar, Sasi, Kesavan, A, Gunasundari, A, Mangalambal, G, Nagarajan, Valarmathi, Shankar, Shakeela, Selvi, R, Vaishnavi, S, Yadav, Krishna, Supriya, R, Giranab, Hema, Seetha, A, Mary, Stella, Gopika, S, Rohini, S, Revathy, M, Balaji, Sarath, Elilarasi, S, Ganesh, J, Aravind, MA, Mulambo, Sylvia, Mwanyungwi, Hope, Tapse, Dharati, Sane, Manasi, Abdullah, Amina, Nakalanzi, Sarah, Williams, Cynthia Mukisa, McIlleron, Helen, Aarnoutse, Rob, Revill, Paul, Love-Koh, James, Walker, Simon, Mugyenyi, Peter, Darbyshire, Janet, Clayden, Polly, Donald, Peter, Singh, Varinder, Grzemska*, Malgosia, Swaminathan, Soumya, Verkuijl, *Replaced by Sabine, Peto, Tim, Mwinga, Alwyn, Fielding, Katherine, Graham, Stephen M., Welch, Steven B., Seddon, James A., Whittaker, Elizabeth, Anderson, Suzanne, and Grandjean, Louis

Published
2023
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11. Efficacy and safety of memantine in children with autism spectrum disorder: Results from three phase 2 multicenter studies

Author

Hardan, Antonio Y, Hendren, Robert L, Aman, Michael G, Robb, Adelaide, Melmed, Raun D, Andersen, Kristen A, Luchini, Rachel, Rahman, Rezwanur, Ali, Sanjida, Jia, X Daniel, Mallick, Madhuja, Lateiner, Jordan E, Palmer, Robert H, and Graham, Stephen M

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Clinical Research, Neurosciences, Brain Disorders, Autism, Clinical Trials and Supportive Activities, Mental Health, Intellectual and Developmental Disabilities (IDD), 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Autism Spectrum Disorder, Child, Delayed-Action Preparations, Double-Blind Method, Early Termination of Clinical Trials, Excitatory Amino Acid Antagonists, Female, Fever, Headache, Humans, Irritable Mood, Male, Memantine, Nasopharyngitis, Social Behavior, Treatment Outcome, Asperger's disorder, autism spectrum disorders, clinical trial, medication, memantine, pervasive developmental disorder-not otherwise specified, randomized withdrawal, school-age children, Social Responsiveness Scale, Asperger’s disorder, Specialist Studies in Education, Cognitive Sciences, Developmental & Child Psychology, Biomedical and clinical sciences
Abstract

Three phase 2 trials were conducted to assess the efficacy and long-term safety of weight-based memantine extended release (ER) treatment in children with autism spectrum disorder. MEM-MD-91, a 50-week open-label trial, identified memantine extended-release treatment responders for enrollment into MEM-MD-68, a 12-week randomized, double-blind, placebo-controlled withdrawal trial. MEM-MD-69 was an open-label extension trial in which participants from MEM-MD-68, MEM-MD-91, and open-label trial MEM-MD-67 were treated ⩽48 weeks with memantine extended release. In MEM-MD-91, 517 (59.6%) participants were confirmed Social Responsiveness Scale responders at week 12; mean Social Responsiveness Scale total raw scores improved two to three times a minimal clinically important difference of 10 points. In MEM-MD-68, there was no difference between memantine and placebo on the primary efficacy parameter, the proportion of patients with a loss of therapeutic response (defined as ⩾10-point increase from baseline in Social Responsiveness Scale total raw score). MEM-MD-69 exploratory analyses revealed mean standard deviation improvement in Social Responsiveness Scale total raw score of 32.4 (26.4) from baseline of the first lead-in study. No new safety concerns were evident. While the a priori-defined efficacy results of the double-blind trial were not achieved, the considerable improvements in mean Social Responsiveness Scale scores from baseline in the open-label trials were presumed to be clinically important.

Published
2019

12. Infant BCG vaccination and risk of pulmonary and extrapulmonary tuberculosis throughout the life course: a systematic review and individual participant data meta-analysis

Author

Martinez, Leonardo, Cords, Olivia, Liu, Qiao, Acuna-Villaorduna, Carlos, Bonnet, Maryline, Fox, Greg J, Carvalho, Anna Cristina C, Chan, Pei-Chun, Croda, Julio, Hill, Philip C, Lopez-Varela, Elisa, Donkor, Simon, Fielding, Katherine, Graham, Stephen M, Espinal, Marcos A, Kampmann, Beate, Reingold, Arthur, Huerga, Helena, Villalba, Julian A, Grandjean, Louis, Sotgiu, Giovanni, Egere, Uzochukwu, Singh, Sarman, Zhu, Limei, Lienhardt, Christian, Denholm, Justin T, Seddon, James A, Whalen, Christopher C, García-Basteiro, Alberto L, Triasih, Rina, Chen, Cheng, Singh, Jitendra, Huang, Li-Min, Sharma, Surendra, Hannoun, Djohar, del Corral, Helena, Mandalakas, Anna M, Malone, LaShaunda L, Ling, Du-Lin, Kritski, Afrânio, Stein, Catherine M, Vashishtha, Richa, Boulahbal, Fadila, Fang, Chi-Tai, Boom, W Henry, Netto, Eduardo Martins, Lemos, Antonio Carlos, Hesseling, Anneke C, Kay, Alexander, Jones-López, Edward C, Horsburgh, C Robert, Lange, Christoph, and Andrews, Jason R

Published
2022
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15. Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension

Author

Aman, Michael G, Findling, Robert L, Hardan, Antonio Y, Hendren, Robert L, Melmed, Raun D, Kehinde-Nelson, Ola, Hsu, Hai-An, Trugman, Joel M, Palmer, Robert H, Graham, Stephen M, Gage, Allyson T, Perhach, James L, and Katz, Ephraim

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Mental Health, Autism, Clinical Trials and Supportive Activities, Pediatric, Intellectual and Developmental Disabilities (IDD), Clinical Research, Patient Safety, Brain Disorders, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Mental health, Autistic Disorder, Child, Delayed-Action Preparations, Dose-Response Relationship, Drug, Double-Blind Method, Excitatory Amino Acid Antagonists, Female, Humans, Male, Memantine, Treatment Outcome, memantine extended release, autistic disorder, tolerability, safety, and adverse events, core symptoms of autism, Social Responsiveness Scale, Children's Communication Checklist-2, tolerability, safety, and adverse events, Developmental & Child Psychology, Pharmacology and pharmaceutical sciences
Abstract

ObjectiveAbnormal glutamatergic neurotransmission is implicated in the pathophysiology of autism spectrum disorder (ASD). In this study, the safety, tolerability, and efficacy of the glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist memantine (once-daily extended-release [ER]) were investigated in children with autism in a randomized, placebo-controlled, 12 week trial and a 48 week open-label extension.MethodsA total of 121 children 6-12 years of age with Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR)-defined autistic disorder were randomized (1:1) to placebo or memantine ER for 12 weeks; 104 children entered the subsequent extension trial. Maximum memantine doses were determined by body weight and ranged from 3 to 15 mg/day.ResultsThere was one serious adverse event (SAE) (affective disorder, with memantine) in the 12 week study and one SAE (lobar pneumonia) in the 48 week extension; both were deemed unrelated to treatment. Other AEs were considered mild or moderate and most were deemed not related to treatment. No clinically significant changes occurred in clinical laboratory values, vital signs, or electrocardiogram (ECG). There was no significant between-group difference on the primary efficacy outcome of caregiver/parent ratings on the Social Responsiveness Scale (SRS), although an improvement over baseline at Week 12 was observed in both groups. A trend for improvement at the end of the 48 week extension was observed. No improvements in the active group were observed on any of the secondary end-points, with one communication measure showing significant worsening with memantine compared with placebo (p = 0.02) after 12 weeks.ConclusionsThis trial did not demonstrate clinical efficacy of memantine ER in autism; however, the tolerability and safety data were reassuring. Our results could inform future trial design in this population and may facilitate the investigation of memantine ER for other clinical applications.

Published
2017

16. Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions

Author

Click, Eleanor S., Song, Rinn, Smith, Jonathan P., Mchembere, Walter, Fajans, Mark, Hariri, Parisa, Okeyo, Elisha, McCarthy, Kimberly D., Gethi, Dickson, Odeny, Lazarus, Musau, Susan, Okumu, Albert, Orwa, James, Perez-Velez, Carlos M., Wright, Colleen A., Andres, Mariaem M., Marais, Ben J., Schaaf, H. Simon, Graham, Stephen M., Cruz, Andrea T., and Cain, Kevin P.

Published
2022
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17. Pediatric Tuberculosis: A Review of Evidence-Based Best Practices for Clinicians and Health Care Providers.

Author

Moore, Brittany K., Graham, Stephen M., Nandakumar, Subhadra, Doyle, Joshua, and Maloney, Susan A.

Subjects
MEDICAL personnel, RESOURCE-limited settings, BEST practices, TUBERCULOSIS, PEDIATRIC therapy
Abstract

Advances in pediatric TB care are promising, the result of decades of advocacy, operational and clinical trials research, and political will by national and local TB programs in high-burden countries. However, implementation challenges remain in linking policy to practice and scaling up innovations for prevention, diagnosis, and treatment of TB in children, especially in resource-limited settings. There is both need and opportunity to strengthen clinician confidence in making a TB diagnosis and managing the various manifestations of TB in children, which can facilitate the translation of evidence to action and expand access to new tools and strategies to address TB in this population. This review aims to summarize existing guidance and best practices for clinicians and health care providers in low-resource, TB-endemic settings and identify resources with more detailed and actionable information for decision-making along the clinical cascade to prevent, find, and cure TB in children. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Microbiological Diagnosis of Tuberculosis Disease in Children – A Prospective Study of Microbiological Yield in Low- and Middle- Income Countries

Author

Olbrich, Laura, primary, Franckling-Smith, Zoe, additional, Larsson, Leyla, additional, Sabi, Issa, additional, Ntinginya, Nyanda Elias, additional, Khosa, Celso, additional, Banze, Denise, additional, Nliwasa, Marriott, additional, Corbett, Elizabeth, additional, Semphere, Robina, additional, Verghese, Valsan Philip, additional, Michael, Joy Sarojini, additional, Ninan, Marilyn, additional, Saathoff, Elmar, additional, McHugh, Timothy D., additional, Razid, Alia, additional, Graham, Stephen M., additional, Song, Rinn, additional, Nabeta, Pamela, additional, Trollip, Andre, additional, Nicol, Mark P., additional, Hoelscher, Michael, additional, Geldmacher, Christof, additional, Heinrich, Norbert, additional, Zar, Heather, additional, and Consortium, RaPaed-AIDA-TB, additional

Published
2024
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19. Community intervention for child tuberculosis active contact investigation and management: study protocol for a parallel cluster randomized controlled trial

Author

Vasiliu, Anca, Eymard-Duvernay, Sabrina, Tchounga, Boris, Atwine, Daniel, de Carvalho, Elisabete, Ouedraogo, Sayouba, Kakinda, Michael, Tchendjou, Patrice, Turyahabwe, Stavia, Kuate, Albert Kuate, Tiendrebeogo, Georges, Dodd, Peter J., Graham, Stephen M., Cohn, Jennifer, Casenghi, Martina, and Bonnet, Maryline

Published
2021
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20. Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosisinfection status: a systematic review and individual-participant data meta-analysis of contact tracing studies

Author

Martinez, Leonardo, Seddon, James A, Horsburgh, C Robert, Lange, Christoph, Mandalakas, Anna M, Martinez, Leonardo, Seddon, James, Liu, Qiao, Acuna Villaorduna, Carlos, Bonnet, Maryline, Carvalho, Anna Cristina C., Chan, Pei-Chun, Hill, Philip C, Lopez-Varela, Elisa, Donkor, Simon, Graham, Stephen M., Villalba, Julian A., Grandjean, Louis, Zellweger, Jean-Pierre, Wang, Jann-Yuan, Verhagen, Lilly M, van Schalkwykn, Cari, van der Loeff, Maarten F Schim, Sloot, Rosa, Trieu, Lisa, Ahuja, Shama Desai, Yoshiyama, Takashi, Mazahir, Rufaida, Martinsonn, Neil A, Jones-López, Edward C., Altet, Neus, Kato, Seiya, Fang, Chi-Tai, Geis, Steffen, Hauri, Anja, Long, Richard, Dobler, Claudia C, Cayla, Joan A, Chakhaia, Tsira, Chen, Cheng, García-Basteiro, Alberto L., Triasih, Rina, Huang, Li-Min, Sharma, Surendra, Hannoun, Djohar, Malone, LaShaunda L., Ling, Du-Lin, Kritski, Afrânio, Stein, Catherine M., Malik, Amyn A, Augusto, Orvalho, Vashishtha, Richa, Boulahbal, Fadila, Boom, W. Henry, Shen, Ye, Hesseling, Anneke C, Horsburgh, C. Robert, Lange, Christoph, and Mandalakas, Anna M.

Abstract

Tuberculosis is a preventable disease. However, there is debate regarding which individuals would benefit most from tuberculosis preventive treatment and whether these benefits vary in settings with a high burden and low burden of tuberculosis. We aimed to compare the effectiveness of tuberculosis preventive treatment in exposed individuals of differing ages and Mycobacterium tuberculosisinfection status while considering tuberculosis burden of the settings.

Published
2024
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21. Diagnostic accuracy of a three-gene Mycobacterium tuberculosis host response cartridge using fingerstick blood for childhood tuberculosis: a multicentre prospective study in low-income and middle-income countries

Author

Olbrich, Laura, primary, Verghese, Valsan P, additional, Franckling-Smith, Zoe, additional, Sabi, Issa, additional, Ntinginya, Nyanda E, additional, Mfinanga, Alfred, additional, Banze, Denise, additional, Viegas, Sofia, additional, Khosa, Celso, additional, Semphere, Robina, additional, Nliwasa, Marriott, additional, McHugh, Timothy D, additional, Larsson, Leyla, additional, Razid, Alia, additional, Song, Rinn, additional, Corbett, Elizabeth L, additional, Nabeta, Pamela, additional, Trollip, Andre, additional, Graham, Stephen M, additional, Hoelscher, Michael, additional, Geldmacher, Christof, additional, Zar, Heather J, additional, Michael, Joy Sarojini, additional, Heinrich, Norbert, additional, Baard, Cynthia Biddle, additional, Munro, Jacinta Diane, additional, Prins, Margaretha, additional, Benzi, Nolufefe, additional, Bateman, Linda Claire, additional, Ryan, Ashleigh, additional, Booi, Kutala, additional, Paulo, Nezisa, additional, Heydenrych, Anthenette, additional, Petersen, Wonita, additional, Brookes, Raquel, additional, Mento, Michele, additional, Centner, Chad, additional, Dalgarno, Craig, additional, Rieß, Friedrich, additional, Mutuku, Sarah, additional, Saathoff, Elmar, additional, Held, Kathrin, additional, Ninan, Marilyn Mary, additional, Chacko, Anila, additional, Kumari, Ramya, additional, Dhanabhagyam, R, additional, Muniswamy, Nithya, additional, Nicol, Marc P, additional, Mtafya, Bariki, additional, Mwambola, Harieth, additional, Manyama, Christina, additional, Mahiga, Hellen, additional, Sichone, Emanuel, additional, Sudi, Lwitiho, additional, Maueia, Cremildo, additional, Madeira, Carla, additional, Cambuie, Justina, additional, Ribeiro, Jorge, additional, Chiume, Lingstone, additional, Mnyanga, Alice, additional, Sikwese, Tionge, additional, Masakasa, Happy, additional, Kachere, Diana, additional, Kosaka, Masheck, additional, Niemann, Stefan, additional, Chegou, Novel, additional, and Horn, Lyn, additional

Published
2023
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22. Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby

Author

Boast, Alison, primary, How, Jeu Ann, additional, Lau, Charis, additional, Sett, Arun, additional, Gilby, Damien, additional, Burke, Andrew, additional, McWhinney, Brett, additional, Wright, Connor, additional, Tramontana, Adrian, additional, Globan, Maria, additional, Denholm, Justin, additional, Graham, Stephen M, additional, and Osowicki, Joshua, additional

Published
2023
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24. List of Contributors

Author

Acosta, Anna M., primary, Acuin, Jose M., additional, Adam, Rodney D., additional, Afroze, Farzana, additional, Ahmed, Nadia, additional, Ahmed, Sabeena, additional, Ahmed, Tahmeed, additional, Ahmed, A.M. Shamsir, additional, Ali, S. Asad, additional, Ali, Ibne K., additional, Alroy, Karen A., additional, Ananthakrishnan, Ashwin N., additional, Ansong, Daniel, additional, Anstead, Gregory M., additional, Appleby, Laura J., additional, Armah, George E., additional, Aronson, Naomi E., additional, Aston, Stephen J., additional, Barnett, Elizabeth D., additional, Bartelt, Luther A., additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Beadling, Charles W., additional, Beeching, Nicholas J., additional, Bennish, Michael L., additional, Bern, Caryn, additional, Bernstein, Wendy B., additional, Bird, Brian H., additional, Bloom, Allyson K., additional, Bodeker, Gerard, additional, Boyer Chammard, Timothée, additional, Bradsher, Robert W., additional, Brooker, Simon J., additional, Brooks, W. Abdullah, additional, Brouqui, Philippe, additional, Brown, Michael, additional, Brown, Michael R., additional, Broyles, Laura N., additional, Bruschi, Fabrizio, additional, Bundy, Donald A.P., additional, Burton, Matthew, additional, Cabrera-Sosa, Luis, additional, Callahan, Michael V., additional, Carapetis, Jonathan R., additional, Cardemil, Cristina V., additional, Carrol, Enitan D., additional, Caswell, Rachel, additional, Caumes, Eric, additional, Cavalheiro, Ana P., additional, Chan, Abner L., additional, Charunwatthana, Prakaykaew, additional, Checkley, Anna M., additional, Chen, Lin H., additional, Chher, Tepirou, additional, Chiong, Charlotte M., additional, Chisti, M. Jobayer, additional, Christiani, David C., additional, Clark, Taryn N., additional, Connor, Bradley A., additional, Conway, Devin J., additional, Cooper, Philip J., additional, Cope, Jennifer R., additional, Coughlin, R. Richard, additional, Coulibaly, Yaya I., additional, Coyle, Christina M., additional, Crozier, Ian, additional, Cunliffe, Nigel A., additional, Cupido, Blanche, additional, Curren, Emily J., additional, Danta, Mark, additional, Day, Nicholas P.J., additional, Debboun, Mustapha, additional, DeFraites, Robert F., additional, Dekumyoy, Paron, additional, del Castillo, Maria, additional, den Hoed, Caroline M., additional, de Silva, Nilanthi, additional, Deye, Gregory, additional, Dillingham, Rebecca A., additional, Drancourt, Michel, additional, Durward, Callum S., additional, Eddleston, Michael, additional, El-Kamary, Samer S., additional, Elshaboury, Ramy H., additional, Endtz, Hubert P., additional, Endy, Timothy P., additional, Fang, Shona C., additional, Fawzi, Wafaie, additional, Feasey, Nicholas A., additional, Field, Vanessa K., additional, Fischer, Marc, additional, Forsyth, Kevin, additional, Fournier, Pierre-Edouard, additional, Friedlander, Arthur M., additional, Furin, Jennifer J., additional, Gandhi, Ronak G., additional, Garcia, Hector H., additional, Garcia, Lynne S., additional, Geretti, Anna Maria, additional, Gikas, Achilleas, additional, Gilman, Robert H., additional, Giri, Sidhartha, additional, Gkika, Meropi, additional, Gordon, Melita A., additional, Gosselin, Richard A., additional, Gotuzzo, Eduardo, additional, Gould, Carolyn V., additional, Graeff-Teixeira, Carlos, additional, Graham, Stephen M., additional, Grant, Alison D., additional, Graybill, John R., additional, Graz, Bertrand, additional, Green, Stephen T., additional, Griffiths, Jeffrey K., additional, Griffiths, Michael J., additional, Gryseels, Bruno, additional, Gubler, Duane J., additional, Guhadasan, Rathi, additional, Hall, Aron J., additional, Hamer, Davidson H., additional, Hand, Robert M., additional, Harley, David, additional, Harris, Jason B., additional, Hassall, Oliver, additional, Hay, Roderick J., additional, Hickey, Patrick, additional, Hill, David R., additional, Hills, Susan L., additional, Hobdell, Martin H., additional, Hochberg, Natasha S., additional, Hopkins, Donald R., additional, Hossain, M. Iqbal, additional, Hotez, Peter J., additional, Howard, Cynthia R., additional, Hu, Victor, additional, Hung, Chien-Ching, additional, Islam, Munirul, additional, Iturriza-Gómara, Miren, additional, Joekes, Elizabeth, additional, Johnston, Victoria, additional, Jose, Jo-Ann, additional, Junghanss, Thomas, additional, Kamgno, Joseph, additional, Kampondeni, Sam, additional, Kang, Gagandeep, additional, Kazanjian, Powel, additional, Keshtkar-Jahromi, Maryam, additional, Keshtkar-Jahromi, Marzieh, additional, Keystone, Jay S., additional, Kim, Arthur Y., additional, Kim, Sung-Han, additional, King, Christopher L., additional, Kittitrakul, Chatporn, additional, Kleine, Christian, additional, Klion, Amy D., additional, Knight, Richard, additional, Koren, Michael, additional, Kottilil, Shyamasundaran, additional, Krause, Peter J., additional, Krishna, Sanjeev, additional, Kuhn, Jens H., additional, Kuipers, Ernst J., additional, LaBeaud, Angelle D., additional, Labra, Patrick John P., additional, Lalloo, David G., additional, Lambert, Saba, additional, Lanternier, Fanny, additional, LaRocque, Regina C., additional, Last, Anna, additional, Lawrenson, John, additional, Le, Thuy, additional, Lee, Keun Hwa, additional, Lewis, David A., additional, Libraty, Daniel H., additional, Lo, Nathan C., additional, Lockwood, Diana N.J., additional, Lockwood, Stephen J., additional, Lommerse, Kinke, additional, López-Vélez, Rogelio, additional, Lortholary, Olivier, additional, Mabey, David, additional, Magill, Alan J., additional, Maguiña, Ciro P., additional, Manji, Hadi, additional, Marks, Michael, additional, Maurin, Max, additional, Mayaud, Philippe, additional, Mayosi, Bongani M., additional, M'baya, Bridon, additional, McCarthy, Matthew W., additional, McCartney, Daniel, additional, McCormick, Joseph B., additional, McKew, Stephen, additional, McLellan, Susan L.F., additional, McMinn, Peter C., additional, Mertz, Gregory, additional, Milner, Danny A., additional, Molyneux, Elizabeth M., additional, Montgomery, Susan P., additional, Moonah, Shannon, additional, Moss, William J., additional, Murrell, K. Darwin, additional, Nanda, Neha, additional, Navarro, Eileen E., additional, Ndayizeye, Leonard, additional, Neafie, Ronald C., additional, Negroni, Ricardo, additional, Nelson, Ann M., additional, Newton, Paul N., additional, Nichol, Stuart T., additional, Norman, Francesca F., additional, Nunes, Marcio R.T., additional, Nutman, Thomas B., additional, Nyirenda, Tonney S., additional, Ochoa, Theresa J., additional, O'Farrell, Nigel, additional, Olayemi, Edeghonghon, additional, Oldfield, Edward C., additional, Omidian, Zahra, additional, Ordaya, Eloy E., additional, Paddock, Christopher D., additional, Paessler, Slobodan, additional, Papanikolaou, Ilias C., additional, Paris, Luc, additional, Parry, Christopher M., additional, Patel, Pragna, additional, Peacock, Sharon J., additional, Peeling, Rosanna W., additional, Persson, Hans, additional, Phillips, Jonathan J., additional, Phillips, Richard O., additional, Poovorawan, Kittiyod, additional, Powers, Ann M., additional, Qamar, Farah Naz, additional, Qureshi, Sonia, additional, Rabe, Ingrid B., additional, Rahman, Atif, additional, Rahmati, Elham, additional, Raizes, Elliot, additional, Ramalho-Ortigao, Marcelo, additional, Raoult, Didier, additional, Rein, Michael F., additional, Retik, Alan B., additional, Reynes, Jean-Marc, additional, Rhatigan, Joseph J., additional, Rickard, Jennifer, additional, Riddle, Mark S., additional, Rimoin, Anne W., additional, Riviello, Robert, additional, Robert, Leon L., additional, Rodrigues, Ema G., additional, Rodriguez, Rubens, additional, Ronald, Allan R., additional, Rosenthal, Benjamin M., additional, Rosmarin, David, additional, Ryan, Edward T., additional, Saavedra, Arturo, additional, Schiaffino, Francesca, additional, Schumacher, Sandra K., additional, Sejvar, James J., additional, Sethi, Aisha, additional, Seung, Kwonjune J., additional, Seydel, Karl B., additional, Shah, Melisa M., additional, Shakoor, Sadia, additional, Shankar, Anuraj H., additional, Sharp, Trueman W., additional, Shin, Sonya S., additional, Shirley, Debbie-Ann, additional, Silachamroon, Udomsak, additional, Smith, Catherine C., additional, Snelling, Thomas L., additional, Solomon, Tom, additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Steiger, Samantha N., additional, Stewart, Robert C., additional, Stich, August, additional, Strickman, Daniel, additional, Suh, Kathryn N., additional, Suhrbier, Andreas, additional, Sutcliffe, Catherine G., additional, Tappe, Dennis, additional, Taylor, Terrie E., additional, Thanh, Nguyen Tat, additional, Thanh, Nguyen Thi, additional, Thwaites, C. Louise, additional, Thwaites, Guy E., additional, Tiwari, Tejpratap S.P., additional, Tsenempi, Xenia A., additional, Turner, Angus W., additional, van den Broek, Nynke R., additional, van Doorn, H. Rogier, additional, Van Sickels, Nicholas J., additional, Vannier, Edouard, additional, Varda, Briony K., additional, Vasconcelos, Pedro F.C., additional, Vega-López, Francisco, additional, Vietri, Nicholas J., additional, Vinetz, Joseph M., additional, Visvesvara, Govinda S., additional, Vyas, Keyur S., additional, Walsh, Thomas J., additional, Wansbrough-Jones, Mark H., additional, Warraich, Haider J., additional, Warrell, David A., additional, Warrell, Mary J., additional, Watt, George, additional, Wattanagoon, Yupaporn, additional, Watthanakulpanich, Dorn, additional, Weaver, Scott C., additional, Weil, Ana A., additional, Weiss, Louis M., additional, White, Nicholas J., additional, Whitty, Christopher J.M., additional, Wilson, Mary E., additional, Xavier, Ramnik J., additional, Xiao, Lihua, additional, Yoon, In-Kyu, additional, Yu, Hongjie, additional, and Zaidi, Anita K.M., additional

Published
2020
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26. A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis

Author

Garcia-Basteiro, Alberto L, Ehrlich, Joanna, Bonnet, Maryline, Calnan, Marianne, Graham, Stephen M, Hermans, Sabine, Jarrett, Adriana, Lewa, Rhoda, Mandalakas, Anna, Martinez, Leonardo, Migliori, Giovanni Battista, Ong, Catherine W M, Otero, Larissa, Rangaka, Molebogeng Xheedha, Raviglione, Mario C B, Seaworth, Barbara, Ssengooba, Willy, Theron, Grant, Trajman, Anete, and Behr, Marcel A

Published
2024
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29. Reckoning with Bias.

Author

Dauchez, Christine and Graham, Stephen M.

Subjects
*RACE relations, *VOCATIONAL guidance, *BLACK people, *CORPORATE directors, *INVESTMENT banking
Abstract

This article is a summary of an interview with Stephen Michael Graham, the author of the book "Invisible Ink: Navigating Racism in Corporate America." Graham reflects on his experiences as the only Black lawyer in the room for most of his career and discusses what kept him going and what gives him hope for the future. He also offers insights on staying engaged in retirement and shares advice for library patrons transitioning to retirement. Graham emphasizes the importance of finding new directions, maintaining social engagement, and not defining self-worth solely by work. He also discusses the need for more progress in addressing racism and implicit biases in various industries. [Extracted from the article]

Published
2024

30. Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby.

Author

Boast, Alison, How, Jeu Ann, Lau, Charis, Sett, Arun, Gilby, Damien, Burke, Andrew, McWhinney, Brett, Wright, Connor, Tramontana, Adrian, Globan, Maria, Denholm, Justin, Graham, Stephen M, and Osowicki, Joshua

Subjects
TREATMENT effectiveness, ANTITUBERCULAR agents
Abstract

We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including bedaquline and delamanid, drugs not previously described in the treatment of congenital tuberculosis (TB). [ABSTRACT FROM AUTHOR]

Published
2024
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31. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Author

Gunasekera, Kenneth S, primary, Marcy, Olivier, additional, Muñoz, Johanna, additional, Lopez-Varela, Elisa, additional, Sekadde, Moorine P, additional, Franke, Molly F, additional, Bonnet, Maryline, additional, Ahmed, Shakil, additional, Amanullah, Farhana, additional, Anwar, Aliya, additional, Augusto, Orvalho, additional, Aurilio, Rafaela Baroni, additional, Banu, Sayera, additional, Batool, Iraj, additional, Brands, Annemieke, additional, Cain, Kevin P, additional, Carratalá-Castro, Lucía, additional, Caws, Maxine, additional, Click, Eleanor S, additional, Cranmer, Lisa M, additional, García-Basteiro, Alberto L, additional, Hesseling, Anneke C, additional, Huynh, Julie, additional, Kabir, Senjuti, additional, Lecca, Leonid, additional, Mandalakas, Anna, additional, Mavhunga, Farai, additional, Myint, Aye Aye, additional, Myo, Kyaw, additional, Nampijja, Dorah, additional, Nicol, Mark P, additional, Orikiriza, Patrick, additional, Palmer, Megan, additional, Sant'Anna, Clemax Couto, additional, Siddiqui, Sara Ahmed, additional, Smith, Jonathan P, additional, Song, Rinn, additional, Thuong Thuong, Nguyen Thuy, additional, Ung, Vibol, additional, van der Zalm, Marieke M, additional, Verkuijl, Sabine, additional, Viney, Kerri, additional, Walters, Elisabetta G, additional, Warren, Joshua L, additional, Zar, Heather J, additional, Marais, Ben J, additional, Graham, Stephen M, additional, Debray, Thomas P A, additional, Cohen, Ted, additional, and Seddon, James A, additional

Published
2023
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33. Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents : a systematic review and individual patient data meta-analysis

Author

Gafar, Fajri, Wasmann, Roeland E., McIlleron, Helen M., Aarnoutse, Rob E., Schaaf, H. Simon, Marais, Ben J., Agarwal, Dipti, Antwi, Sampson, Bang, Nguyen D., Bekker, Adrie, Bell, David J., Chabala, Chishala, Choo, Louise, Davies, Geraint R., Day, Jeremy N., Dayal, Rajeshwar, Denti, Paolo, Donald, Peter R., Engidawork, Ephrem, Garcia-Prats, Anthony J., Gibb, Diana, Graham, Stephen M., Hesseling, Anneke C., Heysell, Scott K., Idris, Misgana I., Kabra, Sushil K., Kinikar, Aarti, Kumar, Agibothu K. Hemanth, Kwara, Awewura, Lodha, Rakesh, Magis-Escurra, Cecile, Martinez, Nilza, Mathew, Binu S., Mave, Vidya, Mduma, Estomih, Mlotha-Mitole, Rachel, Mpagama, Stellah G., Mukherjee, Aparna, Nataprawira, Heda M., Peloquin, Charles A., Pouplin, Thomas, Ramachandran, Geetha, Ranjalkar, Jaya, Roy, Vandana, Ruslami, Rovina, Shah, Ira, Singh, Yatish, Sturkenboom, Marieke G. G., Svensson, Elin M., Swaminathan, Soumya, Thatte, Urmila, Thee, Stephanie, Thomas, Tania A., Tikiso, Tjokosela, Touw, Daan J., Turkova, Anna, Velpandian, Thirumurthy, Verhagen, Lilly M., Winckler, Jana L., Yang, Hongmei, Yunivita, Vycke, Taxis, Katja, Stevens, Jasper, Alffenaar, Jan-Willem C., Gafar, Fajri, Wasmann, Roeland E., McIlleron, Helen M., Aarnoutse, Rob E., Schaaf, H. Simon, Marais, Ben J., Agarwal, Dipti, Antwi, Sampson, Bang, Nguyen D., Bekker, Adrie, Bell, David J., Chabala, Chishala, Choo, Louise, Davies, Geraint R., Day, Jeremy N., Dayal, Rajeshwar, Denti, Paolo, Donald, Peter R., Engidawork, Ephrem, Garcia-Prats, Anthony J., Gibb, Diana, Graham, Stephen M., Hesseling, Anneke C., Heysell, Scott K., Idris, Misgana I., Kabra, Sushil K., Kinikar, Aarti, Kumar, Agibothu K. Hemanth, Kwara, Awewura, Lodha, Rakesh, Magis-Escurra, Cecile, Martinez, Nilza, Mathew, Binu S., Mave, Vidya, Mduma, Estomih, Mlotha-Mitole, Rachel, Mpagama, Stellah G., Mukherjee, Aparna, Nataprawira, Heda M., Peloquin, Charles A., Pouplin, Thomas, Ramachandran, Geetha, Ranjalkar, Jaya, Roy, Vandana, Ruslami, Rovina, Shah, Ira, Singh, Yatish, Sturkenboom, Marieke G. G., Svensson, Elin M., Swaminathan, Soumya, Thatte, Urmila, Thee, Stephanie, Thomas, Tania A., Tikiso, Tjokosela, Touw, Daan J., Turkova, Anna, Velpandian, Thirumurthy, Verhagen, Lilly M., Winckler, Jana L., Yang, Hongmei, Yunivita, Vycke, Taxis, Katja, Stevens, Jasper, and Alffenaar, Jan-Willem C.

Abstract

Background Suboptimal exposure to antituberculosis (anti-TB) drugs has been associated with unfavourable treatment outcomes. We aimed to investigate estimates and determinants of first-line anti-TB drug pharmacokinetics in children and adolescents at a global level. Methods We systematically searched MEDLINE, Embase and Web of Science (1990–2021) for pharmacokinetic studies of first-line anti-TB drugs in children and adolescents. Individual patient data were obtained from authors of eligible studies. Summary estimates of total/extrapolated area under the plasma concentration–time curve from 0 to 24 h post-dose (AUC0–24) and peak plasma concentration (Cmax) were assessed with random-effects models, normalised with current World Health Organization-recommended paediatric doses. Determinants of AUC0–24 and Cmax were assessed with linear mixed-effects models. Results Of 55 eligible studies, individual patient data were available for 39 (71%), including 1628 participants from 12 countries. Geometric means of steady-state AUC0–24 were summarised for isoniazid (18.7 (95% CI 15.5–22.6) h·mg·L−1), rifampicin (34.4 (95% CI 29.4–40.3) h·mg·L−1), pyrazinamide (375.0 (95% CI 339.9–413.7) h·mg·L−1) and ethambutol (8.0 (95% CI 6.4–10.0) h·mg·L−1). Our multivariate models indicated that younger age (especially <2 years) and HIV-positive status were associated with lower AUC0–24 for all first-line anti-TB drugs, while severe malnutrition was associated with lower AUC0–24 for isoniazid and pyrazinamide. N-acetyltransferase 2 rapid acetylators had lower isoniazid AUC0–24 and slow acetylators had higher isoniazid AUC0–24 than intermediate acetylators. Determinants of Cmax were generally similar to those for AUC0–24. Conclusions This study provides the most comprehensive estimates of plasma exposures to first-line anti-TB drugs in children and adolescents. Key determinants of drug exposures were identified. These may be relevant for population-specific dose adjustment or individualis

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2023
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35. Beyond patient delay, navigating structural health system barriers to timely care and treatment in a high burden TB setting in Papua New Guinea

Author

Jops, Paula, primary, Cowan, John, additional, Kupul, Martha, additional, Trumb, Richard Nake, additional, Graham, Stephen M., additional, Bauri, Mathias, additional, Nindil, Herolyn, additional, Bell, Stephen, additional, Keam, Tess, additional, Majumdar, Suman, additional, Pomat, William, additional, Marais, Ben, additional, Marks, Guy B., additional, Kaldor, John, additional, Vallely, Andrew, additional, and Kelly-Hanku, Angela, additional

Published
2023
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41. Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis

Author

Gafar, Fajri, primary, Wasmann, Roeland E., additional, McIlleron, Helen M., additional, Aarnoutse, Rob E., additional, Schaaf, H. Simon, additional, Marais, Ben J., additional, Agarwal, Dipti, additional, Antwi, Sampson, additional, Bang, Nguyen D., additional, Bekker, Adrie, additional, Bell, David J., additional, Chabala, Chishala, additional, Choo, Louise, additional, Davies, Geraint R., additional, Day, Jeremy N., additional, Dayal, Rajeshwar, additional, Denti, Paolo, additional, Donald, Peter R., additional, Engidawork, Ephrem, additional, Garcia-Prats, Anthony J., additional, Gibb, Diana, additional, Graham, Stephen M., additional, Hesseling, Anneke C., additional, Heysell, Scott K., additional, Idris, Misgana I., additional, Kabra, Sushil K., additional, Kinikar, Aarti, additional, Kumar, Agibothu K. Hemanth, additional, Kwara, Awewura, additional, Lodha, Rakesh, additional, Magis-Escurra, Cecile, additional, Martinez, Nilza, additional, Mathew, Binu S., additional, Mave, Vidya, additional, Mduma, Estomih, additional, Mlotha-Mitole, Rachel, additional, Mpagama, Stellah G., additional, Mukherjee, Aparna, additional, Nataprawira, Heda M., additional, Peloquin, Charles A., additional, Pouplin, Thomas, additional, Ramachandran, Geetha, additional, Ranjalkar, Jaya, additional, Roy, Vandana, additional, Ruslami, Rovina, additional, Shah, Ira, additional, Singh, Yatish, additional, Sturkenboom, Marieke G.G., additional, Svensson, Elin M., additional, Swaminathan, Soumya, additional, Thatte, Urmila, additional, Thee, Stephanie, additional, Thomas, Tania A., additional, Tikiso, Tjokosela, additional, Touw, Daan J., additional, Turkova, Anna, additional, Velpandian, Thirumurthy, additional, Verhagen, Lilly M., additional, Winckler, Jana L., additional, Yang, Hongmei, additional, Yunivita, Vycke, additional, Taxis, Katja, additional, Stevens, Jasper, additional, and Alffenaar, Jan-Willem C., additional

Published
2022
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42. Effect of systematic tuberculosis detection on mortality in young children with severe pneumonia in countries with high incidence of tuberculosis: a stepped-wedge cluster-randomised trial

Author

Marcy, Olivier, primary, Wobudeya, Eric, additional, Font, Hélène, additional, Vessière, Aurélia, additional, Chabala, Chishala, additional, Khosa, Celso, additional, Taguebue, Jean-Voisin, additional, Moh, Raoul, additional, Mwanga-Amumpaire, Juliet, additional, Lounnas, Manon, additional, Mulenga, Veronica, additional, Mavale, Sandra, additional, Chilundo, Josina, additional, Rego, Dalila, additional, Nduna, Bwendo, additional, Shankalala, Perfect, additional, Chirwa, Uzima, additional, De Lauzanne, Agathe, additional, Dim, Bunnet, additional, Tiogouo Ngouana, Emeline, additional, Folquet Amorrissani, Madeleine, additional, Cisse, Lassina, additional, Amon Tanoh Dick, Flore, additional, Komena, Eric A, additional, Kwedi Nolna, Sylvie, additional, Businge, Gerald, additional, Natukunda, Naome, additional, Cumbe, Saniata, additional, Mbekeka, Prossy, additional, Kim, Ang, additional, Kheang, Chanrithea, additional, Pol, Sokha, additional, Maleche-Obimbo, Elizabeth, additional, Seddon, James A, additional, Mao, Tan Eang, additional, Graham, Stephen M, additional, Delacourt, Christophe, additional, Borand, Laurence, additional, Bonnet, Maryline, additional, Marcy, Olivier, additional, Serre, Angeline, additional, Badrichani, Anne, additional, Razafimanantsoa, Manoa, additional, Poublan, Julien, additional, Roucher, Clémentine, additional, Occelli, Estelle, additional, Beuscart, Aurélie, additional, Charpin, Aurélie, additional, Habiyambere, Gemma, additional, Mesnier, Salomé, additional, Balestre, Eric, additional, Bhatta, Bandana, additional, Maillard, Anne-Laure, additional, Orne-Gliemann, Joanna, additional, Baillet, Emmanuelle, additional, Koskas, Nicolas, additional, D'Elbée, Marc, additional, Gabillard, Delphine, additional, Huyen, Minh, additional, Espérou, Hélène, additional, Couffin-Cadiergues, Sandrine, additional, Kuppers, Alexis, additional, Hamze, Benjamin, additional, BORAND, Laurence, additional, de LAUZANNE, Agathe, additional, DIM, Bunnet, additional, Keang, Chanthy, additional, PRING, Long, additional, YIN, Song, additional, SARITH, Channimol, additional, PHAN, Chanvirak, additional, NHEUONG, Sovann, additional, LY, Socheat, additional, KAING, Sanary, additional, SRENG, Vouchleang, additional, LUN, Elen, additional, SAY, Leakhena, additional, SUOM, Sophea, additional, FERHY, Romyka, additional, SO, Dina, additional, BORN, Sorunna, additional, PAL, Sophea, additional, NANG, Boraneath, additional, MAO, Tan Eang, additional, KIM, Ang, additional, Srey, Viso, additional, Kan, Piseth, additional, Hout, leakhena, additional, Ith, Samnang, additional, Oum, Sophany, additional, Sau, Sokunvadhana, additional, Ho, Kim Heang, additional, Kith, Daronic, additional, Nuch, Nathara, additional, Horm, Chhun Leang, additional, Sophon, Cheameas, additional, Roeungdeth, Bosba, additional, MENG, Chhay, additional, RITH, Ravin, additional, PHY, Samnang, additional, SOR, Chanchetra, additional, SAO, Voleak, additional, KHAT, Sophea, additional, MAK, Bunthoeun, additional, UY, Angkeaborin, additional, KHAY, Sreyny, additional, SOM, Kimsan, additional, HACH, rongvirak, additional, SOK, Hay, additional, KUON, Sotheavy, additional, HENG, Synatt, additional, SENG, Amara, additional, NIM, Sopheak, additional, PAN, Reach, additional, KIM, Srean, additional, SREY LEAP, Keo, additional, NET, Bormey, additional, NOUN, Viccheka, additional, LAY, Daven, additional, MANY, Chhaing, additional, Seng, Socheata, additional, Ly, Vuthy, additional, So, Saran, additional, Oun, Sovutthik, additional, CHEY, Sopheap, additional, CHHEA, Rattany, additional, BAONG, Lydeth, additional, THOUNG, Vanna, additional, KHEANG, Chanrithea, additional, BY, Borady, additional, Nguon, Vathanak, additional, MEACH, Eksophea, additional, Tek, Sopheak, additional, Ngeav, Sina, additional, Lun, Tetra, additional, HEM, Deth, additional, CHUT, Nayreang, additional, SARIK, Setha, additional, NANG, Hgekkoung, additional, MEACH, Mengnean, additional, SRENG, Sopal, additional, SAR, Dara, additional, KIN, Rathana, additional, ROS, Phoran, additional, DORN, Chenda, additional, KAK, Chansy, additional, Sambath, Srey Leak, additional, Son, Leakhena, additional, Bin, Linda, additional, Pengong, Eangnay, additional, Khutsorn, Samnang, additional, Seang, Sorsophea, additional, Soun, Virak, additional, Vong, Vuthy, additional, Khoeung, Chandara, additional, Um, Panha, additional, Bou, Sokunthea, additional, Song Pich, Sarin, additional, Nim, Puthy, additional, Khat, Sopheak, additional, Ban Si, Nuon, additional, Ream, Sovannodom, additional, Ing, Sim, additional, Chann, Phanith, additional, Ngeth, Samrith, additional, Sun, Marina, additional, Chhoeung, Sokea, additional, Sean, Soeun, additional, Prak, Ratanak, additional, Amboua Schouame Onambele, Audrey, additional, Hycenth, Numfor, additional, Melingui, Bernard, additional, Nkembe Medounmga, Angeline, additional, Hougnang Tatmi, Luciole, additional, Etemgoua, Nathalie, additional, Kouesso, Vanessa, additional, Bugin, Jean, additional, Nzedjom, Celestine, additional, Ngoya, Roger, additional, Eyike, Jules, additional, Loudjom, Elyse, additional, Lonsti, Roger, additional, Dang, Ladi, additional, Bintar, Edward, additional, Njayong, Chantal, additional, Ngonsoa O, Cinthia, additional, Ndzeukap, Isabelle, additional, Dzoyem, Pascaline, additional, Dzokou, Clémentine, additional, Dindo, Berthe, additional, Komena, Eric Auguste, additional, Aka Bony, Roger, additional, Kouadio, Christian, additional, Danho, Serge, additional, Goli, Melissa, additional, Folquet, Madeleine, additional, Itchy, Max Valère, additional, Sidibé, Abdel, additional, Cissé, Lancina, additional, Ouattara, Joseph, additional, Konaté, Mamadou, additional, Amon-Tanoh Dick, Flore, additional, Cardena, Melissa, additional, Adonis-Koffi, Laurence, additional, Eugenie, Djabia, additional, Kouamé, Ferdinand, additional, Menan, Hervé, additional, Inwoley, André, additional, Ouassa, Timothée, additional, Nguessan, Marcelle Sandrine, additional, Manhiça, Emelva, additional, Zitha, Alcina, additional, Chiúle, Valter, additional, Muxanga, Eva, additional, Gune, Irene, additional, Lima, Yara, additional, Ribeiro, Jorge, additional, Maxanguana, Felismina, additional, Morais, Natália, additional, Manhiça, Julieta, additional, Give, Josefina, additional, Atumane, Jafito, additional, Lucas, Gelson, additional, Thai, Arsénio, additional, Chave, Adélio, additional, Guambe, Lúcia, additional, Issa, Faiaz, additional, Carneiro, Rosa, additional, Pene, Neusa, additional, Florindo, Natércia, additional, Machel, Dália, additional, Cumbane, Cecília, additional, Mendes, Helena, additional, Kitungwa, Mule, additional, Muianga, Valdo, additional, Tamele, Humberto, additional, Sulude, Adelino, additional, Mabota, Roda, additional, Comandante, Herquéria, additional, Massangaie, Abelardo, additional, Businge, Gerald Bright, additional, Namulinda, Faith, additional, Sserunjogi, Robert, additional, Nassozi, Rashidah, additional, Barungi, Charlotte, additional, Aanyu, Hellen, additional, Muwonge, Doreen, additional, Kagoya, Eva, additional, Aciparu, Serene, additional, Chemutai, Sophia, additional, Ntambi, Samuel, additional, Wasswa, Amir, additional, Nangozi, Juliet, additional, Tagoola, Abner, additional, Kenneth, Sajja, additional, Lubega, John Paul, additional, Nassali, Aidah, additional, Tagobera, Jessica, additional, Agwang, Christine, additional, Kalembe, Florence, additional, Ajambo, Annet, additional, Aguti, Elizabeth, additional, Kasibante, Samuel, additional, Matende, Henry, additional, Odongo, Israel Owen, additional, Mwanga Amumpaire, Juliet, additional, Ngabirano, Gertrude, additional, Kakwenza, Paul, additional, Nuwamanya, Simpson, additional, Nyangoma, Miria, additional, Nabbuto, Jane, additional, Abok, Florence, additional, Arinaitwe, Rinah, additional, Birungi, Diana, additional, Mwesigwa, Evans, additional, Atwine, Daniel, additional, Mbega, Hassan, additional, Orikiriza, Patrick, additional, Taremwa, Ivan, additional, Turyashemererwa, Esther, additional, Derrick, Hope, additional, Nyehangane, Dan, additional, Kaitano, Rodney, additional, Logoose, Susan, additional, Businge, Steven, additional, Ntambi, Charles, additional, Mugabi, Jerome, additional, Mzee, John, additional, Besigye, Julius, additional, Kanzira, Saul, additional, Turyatemba, Phionah, additional, Twebaze, Florence, additional, Hambulo, Chimuka, additional, Kapotwe, Vincent, additional, Ngambi, Marjory, additional, Kasakwa, Kunda, additional, Kapula, Chifunda, additional, Zulu, Susan, additional, Nawakwi, Grace, additional, Siasulingana, Teddy, additional, Chilonga, Jessy, additional, Chimbini, Maria, additional, Chilanga, Mutinta, additional, Inambao, Muleya, additional, Mwambazi, Mwate, additional, Halende, Barbra, additional, Mumba, Wyclef, additional, Mankunshe, Endreen, additional, Silavwe, Maureen, additional, Chakopo, Moses, additional, and Moono, Roy, additional

Published
2022
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48. Development and validation of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis

Author

Gunasekera, Kenneth S., primary, Marcy, Olivier, additional, Muñoz, Johanna, additional, Lopez-Varela, Elisa, additional, Sekadde, Moorine P., additional, Franke, Molly F., additional, Bonnet, Maryline, additional, Ahmed, Shakil, additional, Amanullah, Farhana, additional, Anwar, Aliya, additional, Augusto, Orvalho, additional, Aurilio, Rafaela Baroni, additional, Banu, Sayera, additional, Batool, Iraj, additional, Brands, Annemieke, additional, Cain, Kevin P., additional, Carratalá-Castro, Lucía, additional, Caws, Maxine, additional, Click, Eleanor S., additional, Cranmer, Lisa M., additional, García-Basteiro, Alberto L., additional, Hesseling, Anneke C., additional, Huynh, Julie, additional, Kabir, Senjuti, additional, Lecca, Leonid, additional, Mandalakas, Anna, additional, Mavhunga, Farai, additional, Myint, Aye Aye, additional, Myo, Kyaw, additional, Nampijja, Dorah, additional, Nicol, Mark P., additional, Orikiriza, Patrick, additional, Palmer, Megan, additional, Sant’Anna, Clemax Couto, additional, Siddiqui, Sara Ahmed, additional, Smith, Jonathan P., additional, Song, Rinn, additional, Thuong Thuong, Nguyen Thuy, additional, Ung, Vibol, additional, van der Zalm, Marieke M., additional, Verkuijl, Sabine, additional, Viney, Kerri, additional, Walters, Elisabetta G., additional, Warren, Joshua L., additional, Zar, Heather J., additional, Marais, Ben J., additional, Graham, Stephen M., additional, Debray, Thomas P. A., additional, Cohen, Ted, additional, and Seddon, James A., additional

Published
2022
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