102 results on '"Grassi FR"'
Search Results
2. Immediate occlusal loading of one-piece zironia implants: five years radiographic and clinical evaluation
- Author
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Grassi, Fr, Capogreco, M, Consonni, D, Buti, J, and Kalemaj, Zamira
- Published
- 2015
3. Viscous Effects on the Mapping of the Initial to Final State in Heavy Ion Collisions
- Author
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Gardim, Fernando G., Noronha-Hostler, Jacquelyn, Luzum, Matthew, and Grassi, Fr��d��rique
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Nuclear Theory (nucl-th) ,High Energy Physics - Phenomenology ,High Energy Physics - Phenomenology (hep-ph) ,Nuclear Theory ,FOS: Physical sciences ,Nuclear Experiment - Abstract
We investigate the correlation between various aspects of the initial geometry of heavy ion collisions at the Relativistic Heavy Ion Collider energies and the final anisotropic flow, using v-USPhydro, a 2+1 event-by-event viscous relativistic hydrodynamical model. We test the extent of which shear and bulk viscosity affect the prediction of the final flow harmonics, $v_n$, from the initial eccentricities, $\varepsilon_n$. We investigate in detail the flow harmonics $v_1$ through $v_5$ where we find that $v_1$, $v_4$, and $v_5$ are dependent on more complicated aspects of the initial geometry that are especially important for the description of peripheral collisions, including a non-linear dependence on eccentricities as well as a dependence on shorter-scale features of the initial density. Furthermore, we compare our results to previous results from NeXSPheRIO, a 3+1 relativistic ideal hydrodynamical model that has a non-zero initial flow contribution, and find that the combined contribution from 3+1 dynamics and non-zero, fluctuating initial flow decreases the predictive ability of the initial eccentricities, in particular for very peripheral collisions, but also disproportionately in central collisions., 12 pages, 11 figures
- Published
- 2014
4. Sodium iodide associated to salicylic acid in the topical management of chronic oral candidiasis: a randomized trial
- Author
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PETRUZZI M, GRASSI FR, NARDI GM, MARTINELLI D, LUGLIE PF, BALDONI E., SERPICO, Rosario, Petruzzi, M, Grassi, Fr, Nardi, Gm, Martinelli, D, Serpico, Rosario, Luglie, Pf, and Baldoni, E.
- Published
- 2010
5. La frenulectomia nella pratica odontoiatrica: Position Paper
- Author
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BALLINI A, PERILLO L, CANTORE S, DE FRENZA G, GRASSI FR, Di Stefano D., Ballini, A, Perillo, L, Cantore, S, DE FRENZA, G, Grassi, Fr, and Di Stefano, D.
- Published
- 2009
6. An Alternative Approach for the Treatment of Major Aphthosis: Case Report
- Author
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Nardi, GM, Grassi, FR, Petruzzi, M., LAURITANO, DORINA, Nardi, G, Grassi, F, Lauritano, D, and Petruzzi, M
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Biofilm, rheumatoid arthritis, ederly, dentistry, oral medicine ,Major aphthosis ,Topical treatment ,Ulcerous stomatitis ,MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,NO - Abstract
An effective treatment for aphthous stomatitis is not still available and its treatment consists only of therapeutic measures to suppress its symptoms. We report a case of a 60-year caucasian woman presented a 16-year history of episodes of multiple major recurrent ulcers in the oral mucosa. Topical application of Oralmedic® caused an improvement of pain, discomfort and healing of the aphthous ulcer. No adverse events or side effects were recorded. Oralmedic® is an effective topical device for the major aphthous ulcers treatment
- Published
- 2014
7. Osseointegration of different dental implants: histological and histomorfometric analysis in vivo
- Author
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Kalemaj, Zamira and Grassi, Fr
- Published
- 2014
8. Immediate transmucosal implant placement in molar extraction sites: a 12-month prospective multicenter cohort study
- Author
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Cafiero C, Annibali S, Gherlone E, Grassi FR, Gualini F, Magliano A, Romeo E, Tonelli P, Lang NP, Salvi GE, ITI Study Group Italia, Cafiero, C, Annibali, S, Gherlone, E, Grassi, Fr, Gualini, F, Magliano, A, Romeo, E, Tonelli, P, Lang, Np, Salvi, Ge, ITI Study Group, Italia, Cafiero, Carlo, ITI Study Group, I. t. a. l. i. a., and Gherlone, FELICE ENRICO
- Subjects
Molar ,Adult ,Male ,Bone Regeneration ,Time Factors ,Surface Properties ,Alveolar Bone Loss ,Dentistry ,Bone Matrix ,Dental Implants, Single-Tooth ,medicine ,Humans ,Prospective Studies ,Tooth Socket ,Prospective cohort study ,Bone regeneration ,Survival rate ,Aged ,Periodontitis ,Aged, 80 and over ,Postoperative Care ,Crowns ,business.industry ,Dental prosthesis ,Dental Implantation, Endosseous ,Soft tissue ,Middle Aged ,medicine.disease ,Radiography ,Dental Prosthesis Design ,Tooth Extraction ,Guided Tissue Regeneration, Periodontal ,Female ,Implant ,Dental Prosthesis, Implant-Supported ,Oral Surgery ,business ,extraction socket ,guided bone ,immediate implants ,regeneration (gbr) ,tapered implants ,transmucosal healing - Abstract
Aim: To assess the clinical and radiographic outcomes of immediate transmucosal placement of implants into molar extraction sockets. Study design: Twelve-month multicenter prospective cohort study. Material and methods: Following molar extraction, tapered implants with an endosseous diameter of 4.8 mm and a shoulder diameter of 6.5 mm were immediately placed into the sockets. Molars with evidence of acute periapical pathology were excluded. After implant placement and achievement of primary stability, flaps were repositioned and sutured allowing a non-submerged, transmucosal healing. Peri-implant marginal defects were treated according to the principles of guided bone regeneration (GBR) by means of deproteinized bovine bone mineral particles in conjunction with a bioresrobable collagen membrane. Standardized radiographs were obtained at baseline and 12 months thereafter. Changes in depth and width of the distance from the implant shoulder (IS) and from the alveolar crest (AC) to the bottom of the defect (BD) were assessed. Results: Eighty-two patients (42 males and 40 females) were enrolled and followed for 12 months. They contributed with 82 tapered implants. Extraction sites displayed sufficient residual bone volume to allow primary stability of all implants. Sixty-four percent of the implants were placed in the areas of 36 and 46. GBR was used in conjunction with the placement of all implants. No post-surgical complications were observed. All implants healed uneventfully yielding a survival rate of 100% and healthy soft tissue conditions after 12 months. Radiographically, statistically significant changes (P
- Published
- 2008
9. PRP:The good, the bad, and the ugly
- Author
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PETRUZZI M, GRASSI FR, DE BENEDITTIS M, SERPICO, Rosario, Petruzzi, M, Grassi, Fr, DE BENEDITTIS, M, and Serpico, Rosario
- Published
- 2005
10. Experimental-numerical investigation on the biomimetic recovery of natural tooth structural response after porcelain veneer restoration
- Author
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Genovese, K, Cosola, E, Lamberti, Luciano, Bux, Mv, Grassi, Fr, Pappalettere, Carmine, and Carlaio, Rg
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electronic speckle pattern interferometry ,3D finite element analysis ,biomimetics ,inverse experimental-numerical approach ,non-carious cervical lesions ,optimisation ,porcelain veneer - Published
- 2012
11. Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study
- Author
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Petruzzi, M, Lucchese, A, Nardi, G, Lauritano, D, Favia, G, Serpico, R, Grassi, F, Nardi, GM, Grassi, FR, LAURITANO, DORINA, Petruzzi, M, Lucchese, A, Nardi, G, Lauritano, D, Favia, G, Serpico, R, Grassi, F, Nardi, GM, Grassi, FR, and LAURITANO, DORINA
- Abstract
The objective was to compare toluidine blue (TB) and autofluorescence (AF) for the detection of oral dysplasia and squamous cell carcinoma (OSCC) in clinically suspicious lesions according to conventional examination. Fifty-six clinically suspicious lesions were subjected to AF and TB examination. Data were compared using two different scenarios: in the first, mild dysplasia was considered as positive, while in the second, it was considered as negative. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), accuracy, and concordance were calculated. AF sensitivity and specificity were 70.0 and 57.7%, respectively, while TB showed a sensitivity of 80% and a specificity of 61.5%. The sensitivity increased in the second scenario in both AF (76.5%) and TB (88.2%). The specificity decreased in AF and TB, showing the same value (51.3%). PPV was higher in TB than in AF (70.6 versus 65.6%) and similarly for NPV (72.7 versus 62.5%). In the second scenario, TB PPV was 44.1% and NPV was 90.9%; AF PPV was 40.6% and NPV was 83.3%. TB showed greater accuracy than AF in the first scenario (62.5 versus 58.9%). AF and TB are both sensitive but not specific in OSCC and dysplasia diagnosis
- Published
- 2014
12. An Alternative Approach for the Treatment of Major Aphthosis: Case Report
- Author
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Nardi, G, Grassi, F, Lauritano, D, Petruzzi, M, Nardi, GM, Grassi, FR, Petruzzi, M., LAURITANO, DORINA, Nardi, G, Grassi, F, Lauritano, D, Petruzzi, M, Nardi, GM, Grassi, FR, Petruzzi, M., and LAURITANO, DORINA
- Abstract
An effective treatment for aphthous stomatitis is not still available and its treatment consists only of therapeutic measures to suppress its symptoms. We report a case of a 60-year caucasian woman presented a 16-year history of episodes of multiple major recurrent ulcers in the oral mucosa. Topical application of Oralmedic® caused an improvement of pain, discomfort and healing of the aphthous ulcer. No adverse events or side effects were recorded. Oralmedic® is an effective topical device for the major aphthous ulcers treatment
- Published
- 2014
13. Full mouth disinfection with PVP-iodine 0,1% vs. conventional periodontal therapy: a pilot study on 14 patients
- Author
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Nardi, Gianna Maria, Rizzo, L., Petruzzi, M, Pappalardo, S., and Grassi, Fr
- Published
- 2005
14. Oral lichen planus and dental hygiene: a case report
- Author
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Scattarella, A, primary, Petruzzi, M, additional, Ballini, A, additional, Grassi, FR, additional, and Nardi, GM, additional
- Published
- 2010
- Full Text
- View/download PDF
15. Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFα, and IL-7 in anin vitromodel derived from human psoriatic arthritis
- Author
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Colucci, S, primary, Brunetti, G, additional, Cantatore, FP, additional, Oranger, A, additional, Mori, G, additional, Quarta, L, additional, Cirulli, N, additional, Mancini, L, additional, Corrado, A, additional, Grassi, FR, additional, and Grano, M, additional
- Published
- 2007
- Full Text
- View/download PDF
16. Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFα, and IL-7 in an in vitro model derived from human psoriatic arthritis.
- Author
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Colucci, S, Brunetti, G, Cantatore, FP, Oranger, A, Mori, G, Quarta, L, Cirulli, N, Mancini, L, Corrado, A, Grassi, FR, and Grano, M
- Abstract
Psoriatic arthritis (PsA) is an inflammatory joint disease, characterized by extensive bone resorption, whose mechanisms have not been fully elucidated. Thus, in the present study we investigated the involvement of RANKL, TNFα, and IL-7 in the osteoclastogenesis of PsA patients. In vitro osteoclastogenesis models, consisting of unfractionated and T-cell-depleted mononuclear cells from peripheral blood (PBMCs) and synovial fluid (SFMCs) of 20 PsA patients as well as from healthy donors were studied. Freshly isolated T and B cells from PBMCs and T cells and fibroblasts from SFMCs of PsA patients were subjected to RT-PCR to detect the levels of RANKL, TNFα, and IL-7. Osteoclastogenesis was studied in the presence of RANK-Fc, anti-TNFα, and anti IL-7 functional antibodies. We demonstrate that lymphocytes and fibroblasts support osteoclast (OC) formation in PsA patients through the production of osteoclastogenic cytokines. In particular, OC formation was completely abolished in unstimulated T cell-depleted PBMC cultures, and reduced by approximately 70% in unstimulated T cell-depleted SFMC cultures. Freshly isolated T cells from PBMCs and SFMCs of PsA patients overexpressed RANKL and TNFα, while fibroblasts from synovial fluid produced only RANKL. We show that the presence of RANK-Fc and/or anti-TNFα functional antibodies reduced OC formation. Moreover, T and B cells from PBMCs as well as T cells and fibroblasts from SFMCs expressed IL-7 mRNA. Finally, the anti-IL-7 functional antibody significantly reduced osteoclastogenesis. Our results suggest that fibroblasts, B and T lymphocytes support OC formation by producing RANKL, TNFα, and IL-7, contributing to the aggressive bone resorption in PsA patients. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
17. Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- Author
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Andrea Cassandro, Mariasevera Di Comite, Dorina Lauritano, Massimo Petruzzi, Felice Roberto Grassi, Adriana Mosca, Fedora Della Vella, Maria Contaldo, Petruzzi, M, Della Vella, F, Cassandro, A, Mosca, A, Comite, M, Contaldo, M, Grassi, F, Lauritano, D, della Vella, F, Di Comite, M, and Grassi, Fr
- Subjects
Male ,Luminescence ,Light ,Biopsy ,Yeast and Fungal Models ,autofluorescence ,Pathology and Laboratory Medicine ,01 natural sciences ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Economica ,Candidiasis, Oral ,Medicine and Health Sciences ,Prospective Studies ,Candida albicans ,Prospective cohort study ,Candida ,Fungal Pathogens ,Multidisciplinary ,biology ,medicine.diagnostic_test ,Organic Compounds ,Physics ,Electromagnetic Radiation ,Optical Imaging ,Candidiasis ,Eukaryota ,MED/28 - MALATTIE ODONTOSTOMATOLOGICHE ,Middle Aged ,Molecular Imaging ,Chemistry ,medicine.anatomical_structure ,Infectious Diseases ,Experimental Organism Systems ,Artificial Light ,Medical Microbiology ,Predictive value of tests ,Physical Sciences ,Medicine ,Female ,Anatomy ,Pathogens ,oral pathology ,Research Article ,Adult ,medicine.medical_specialty ,Porphyrins ,Urology ,Science ,Sexually Transmitted Diseases ,oral medicine ,Mycology ,Research and Analysis Methods ,oral medicine, candida albicans, autofluorescence, oral pathology ,Sensitivity and Specificity ,Microbiology ,Fluorescence ,010309 optics ,03 medical and health sciences ,Tongue ,Predictive Value of Tests ,Internal medicine ,0103 physical sciences ,medicine ,Humans ,LS7_2 ,Microbial Pathogens ,Aged ,Mouth ,business.industry ,Genitourinary Infections ,Organic Chemistry ,Organisms ,Fungi ,Chemical Compounds ,Biology and Life Sciences ,030206 dentistry ,Gold standard (test) ,biology.organism_classification ,Porphyrin ,Yeast ,Autofluorescence ,chemistry ,Animal Studies ,candida albicans ,business ,Digestive System - Abstract
Aim To investigate the correlation between the dorsal tongue porphyrin autofluorescence, revealed using VELscope, and Candida saprophytism. Material and methods Consecutive patients underwent an autofluorescence examination by the VELscope device to establish the presence or absence of porphyrin fluorescence. A tongue swab was collected for the Candida cultural test. Sensitivity, specificity, accuracy, negative predictive value and positive predictive value were calculated considering the oral swab as the gold standard. The degree of agreement between the two tests was calculated using Cohen's K coefficient. Results One hundred twenty-six patients were enrolled. Porphyrin fluorescence method showed a sensitivity of 78%, specificity of 76% and an accuracy of 78%. Negative predictive value and positive predictive value were respectively 90% and 59%. The strength of agreement between the two methods resulted to be moderate (k = 0.551). Conclusions Off-label use of tongue autofluorescence examination to detect the presence of Candida species is characterized by a loss of porphyrin fluorescence. The high negative predictive value of porphyrin fluorescence loss suggests its use in preliminary selection of Candida carriers, in order to plan preventive and therapeutic strategies.
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- 2019
18. Transmission of Nonviral Sexually Transmitted Infections and Oral Sex
- Author
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Vito Crincoli, Andrea Ballini, Paolo Romita, Stefania Cantore, Danila De Vito, V. Montenegro, Biagio Rapone, Felice Roberto Grassi, Laura Fatone, Letizia Perillo, Caterina Foti, Annarita Antelmi, Giovanni Miniello, Francesco Pettini, Ballini, A, Cantore, S, Fatone, L, Montenegro, V, DE VITO, D, Pettini, F, Crincoli, V, Antelmi, A, Romita, P, Rapone, B, Miniello, G, Perillo, Letizia, Grassi, Fr, and Foti, C.
- Subjects
Male ,Sexual behavior ,medicine.medical_specialty ,Oral sex ,Nonviral-sexually transmissible infection ,Sexual health ,Urology ,Endocrinology, Diabetes and Metabolism ,MEDLINE ,Sexually Transmitted Diseases ,Human sexuality ,Endocrinology ,Pregnancy ,medicine ,Humans ,Pregnancy Complications, Infectious ,Genital intercourse ,Reproductive health ,Gynecology ,business.industry ,Vaginal microbicide ,Transmission (medicine) ,Public health ,Orogenital sexual activity ,Clinical trial ,Psychiatry and Mental health ,Reproductive Medicine ,Family medicine ,Female ,business ,Sexual function - Abstract
Introduction Oral sex is usually considered a lower‐risk sexual activity when compared with sex, but it is frequently the cause of sexually transmitted infections (STI). In particular, STI transferred through oral sex might have no visible symptoms, depending on the type of infection. Aims The aim of this study is to review the literature about the role of oral sex in the transmission of nonviral STI. Main Outcome Measures State‐of‐the‐art information in the area of STI in relation to sexual function and self–care, this last important for development of STI prevention products such as vaginal microbicides. Sexual behaviors assessed focusing on receiving oral sex and giving oral sex. Methods A search of the main electronic databases including registers of clinical controlled trials was performed in addition to a hand search of the most relevant Journals. The following electronic databases were searched: PubMed, Embase, Google Scholar, literature review of research articles, and public health department Internet Web sites, for the period of 1945–2011. In addition to searching the Clinical Trials Registry at the US National Institutes of Health, we also used the meta Register of Controlled Trials and the Cochrane Central Register of Controlled Trials. Results STI affect the mucous membranes both directly and indirectly producing characteristic diagnostic signs and lesions. Daily dental clinical activity needs an appropriate knowledge of any kind of oral lesions‐related STI. The reader is offered a practical approach with clinically relevant recommendations that may prove useful in his/her daily practice when dealing with STI. Conclusions. These data provide a foundation for understanding diverse STI. We advise physicians to be receptive to discuss sexuality issues and provide patients with adequate therapy. Ballini A, Cantore S, Fatone L, Montenegro V, De Vito D, Pettini F, Crincoli V, Antelmi A, Romita P, Rapone B, Miniello G, Perillo L, Grassi FR, and Foti C. Transmission of nonviral sexually transmitted infections and oral sex. J Sex Med 2012;9:372–384.
- Published
- 2012
19. THE ROLE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN PERIODONTAL DISEASE
- Author
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G.M. Nardi, Stefania Cantore, Stefano Tetè, Enrico Gherlone, Felice Roberto Grassi, Andrea Ballini, Filiberto Mastrangelo, Letizia Perillo, Francesco Papa, Adele Scattarella, Vito Crincoli, Ballini, A, Tetè, S, Scattarella, A, Cantore, S, Mastrangelo, Filiberto, Papa, F, Nardi, Gm, Perillo, L, Crincoli, V, Gherlone, FELICE ENRICO, Grassi, Fr, Mastrangelo, F, MARIA NARDI, G, Perillo, Letizia, Gherlone, E, and Grassi, F. R.
- Subjects
Adult ,Male ,musculoskeletal diseases ,Immunology ,Arthritis ,anti-cyclic citrullinated peptide antibodies ,rheumatoid arthritis ,periodontal disease ,peptidylarginine deiminase ,Peptide ,Peptides, Cyclic ,Anti-cyclic citrullinated peptide antibodie ,Arthritis, Rheumatoid ,Pathogenesis ,medicine ,Humans ,Immunology and Allergy ,Synovial fluid ,skin and connective tissue diseases ,Pathogen ,Pathological ,Rheumatoid arthriti ,Periodontal Diseases ,Aged ,Autoantibodies ,Pharmacology ,chemistry.chemical_classification ,anti-c_vclic cirmllinaled peptide antibodie ,biology ,Peptidylarginine deiminase ,business.industry ,Middle Aged ,medicine.disease ,chemistry ,Rheumatoid arthritis ,biology.protein ,Female ,Periodontal disease ,Antibody ,business - Abstract
The anti-Cyclic Citrullinated Peptide Antibodies (anti-CCP) are produced locally in the inflamed synovium of Rheumatoid arthritis (RA) patients, suggesting that citrullinated proteins are located in the inflamed synovium. In scientific literature were find periodontal bacterial DNA in serum and synovial fluid of RA with PD patients. RA and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings RA. One oral pathogen strongly implicated in the pathogenesis of periodontal disease (PD), Porphyromonas. gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. Under this point of view, we speculate about the presence of anti-CCP antibodies in sera of PD with RA patients. We conducted this study to evaluate and compare the diagnostic and predictive utility of anti-CCP antibodies in patients with PD and patients with PD and RA. Anti-CCP antibody was not found in 21 sera (U/ml
- Published
- 2010
20. Isolated lichen planus of the lip
- Author
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Rosario Serpico, Massimo Petruzzi, L. Pastore, Felice Roberto Grassi, Giuseppe Pannone, M. De Benedittis, Petruzzi, M, DE BENEDITTIS, M, Pastore, L, Pannone, G, Grassi, Fr, and Serpico, Rosario
- Subjects
Male ,medicine.medical_specialty ,Administration, Topical ,Immunology ,Anti-Inflammatory Agents ,Tocopherols ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Tongue ,Hcv hepatitis ,Genetic predisposition ,Immunology and Allergy ,Medicine ,Humans ,Medical history ,Aged ,Pharmacology ,Aged, 80 and over ,Clobetasol ,Floor of mouth ,business.industry ,Middle Aged ,medicine.disease ,Dermatology ,Lip ,stomatognathic diseases ,Drug Combinations ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,Oral lichen planus ,Female ,Differential diagnosis ,Clobetasol propionate ,business ,030215 immunology ,medicine.drug ,Lichen Planus, Oral - Abstract
Oral lichen planus (OLP) is a relatively common disorder whose cause is still unknown. It occurs mostly on the buccal mucosa, but the gingivae, tongue, floor of the mouth and retromalar pads may also be affected. It rarely occurs on the lips and usually in association with oral lesions. We report a case series of ten patients with a history of isolated swelling of the lower and/or upper lip, erosions and crusting. General medical history, examination of the oral cavity and recording of signs and symptoms were carried out for each patient. Among the six different clinical variants of OLP described by Andreasen, the atrophic-erosive form was the most common in the course of isolated LP of the lip in our series. Five cases presented HCV hepatitis. A complete remission of lesions was observed in eight patients after topical treatment with clobetasol propionate 0.05% and tocopherol oil, while partial improvement was noted in those remaining. Isolated LP of the lip is unusual and presents a diagnostic challenge, however an appropriate differential diagnosis is fundamental. Lesions of the lips might represent a more or less precocious phase of oral involvement. Moreover the reasons for the unique localization on the lips need to be explored. Several variables, including age, duration of lesions, concomitance of other diseases, and genetic predisposition may be involved. Isolated LP of the lip is a well-known condition which responds well to topical treatment with corticosteroids. A thorough medical management and active early treatment are necessary to improve symptoms and might also be a relevant prevention strategy from squamous cell carcinoma risk, although data to fully support this statement still need investigation.
- Published
- 2007
21. Study on the effectiveness of a nifedipine gel for treatment of Raynaud's phenomenon
- Author
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Foti, C., Quaranta, D., Pepe, M. L., Morea, G., Mastropasqua, D., D Amore, M., Mastrangelo, F., Tetè, S., Grassi, F. R., Andrea Ballini, Salini, V., Amicis, D., Scagliusi, P., Lutiis, M. A., Caraffa, A., Cerulli, G., Foti, C, Quaranta, D, Pepe, Ml, Morea, G, Mastropasqua, D, D'Amore, M, Mastrangelo, Filiberto, S., Tete', Grassi, Fr, Ballini, A, Salini, V, DE AMICIS, D, Scagliusi, P, DE LUTIIS, Ma, Caraffa, A, and Cerulli, G.
- Published
- 2006
22. Peno-gingival lichen planus
- Author
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Massimo Petruzzi, Michele De Benedittis, Rosario Serpico, L. Pastore, Felice Roberto Grassi, Petruzzi, M, DE BENEDITTIS, M, Pastore, L, Grassi, Fr, and Serpico, Rosario
- Subjects
medicine.medical_specialty ,business.industry ,Mucosal lesions ,Follow up studies ,Treatment options ,Dermatology ,Genital lesions ,Management algorithm ,stomatognathic diseases ,Periodontics ,Medicine ,Sex organ ,Medical history ,Clobetasol propionate ,business ,medicine.drug - Abstract
Background: Lichen planus with simultaneous oral and genital involvement in males is a quite rare condition and often difficult to diagnose. The prevalence, treatment options, and management for this condition are far from being established, and research in this area primarily relies on anecdotes. We present the clinical features of eight cases of peno-gingival lichen planus and propose a management algorithm for this condition based on the best available published evidence.Methods: Personal medical history was collected for all cases. Following careful examination of the oral and genital mucosae, pathology was obtained, previous treatments and duration of mucosal lesions ascertained, treatment initiated, and response evaluated at 8 weeks on both oral and genital lesions. The first-line drug was topical clobetasol propionate 0.05% cream in all cases; in case of failure, topical cyclosporin was used. A review of the literature on treatment options for this rare condition was performed based upon standard l...
- Published
- 2005
23. Il laser in protesi fissa (Capitolo 14)
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GHERLONE , FELICE ENRICO, Covani u, Crespi R, Grassi FR, and Gherlone, FELICE ENRICO
- Published
- 2004
24. Interleukin-7 production by B lymphocytes affects the T cell-dependent osteoclast formation in an in vitro model derived from human periodontitis patients
- Author
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Colucci, S., Mori, G., Brunetti, G., Coricciati, M., Pignataro, P., Oranger, A., Cirulli, N., Mastrangelo, F., Grassi, F. R., Maria Grano, Colucci, S, Mori, G, Brunetti, G, Coricciati, M, Pignataro, P, Oranger, A, Cirulli, N, Mastrangelo, Filiberto, Grassi, Fr, and Grano, M.
- Subjects
B CELLS AND T CELLS ,IL-7 ,OSTEOCLASTOGENESIS - Abstract
PERIODONTITIS IS CHARACTERIZED BY IRREVERSIBLE DESTRUCTION OF ALVEOLAR BONE AND CONNECTIVE TISSUE ATTACHMENT IN THE PERIODONTIUM. WE RECENTLY REPORTED THAT T CELL SUPPORT THE OSTEOCLASTOGRENESIS BY THE OVERPRODUCTION OF NUCLEAR FACTOR-KAPPA-B-LIGAND (RANKL) AND TUMOR NECROSIS FACTORS ALFA(TNFa) IN AN IN VITRO OSTEOCLASTOGENESIS MODEL FROM PERIODONTITIS PATIENTS (Pp). IT IS KNOW THAT IL7 STIMULATES THE PRODUCTION OF OSTEOCLASTOGENESIS FACTORS BY T CELLS AND IL6 POTENTIATES IL7 EXPRESSION. THUS WE STUDIES THE INVOLVEMENT OF IL6 AND IL7 IN THE T CELLS REGULATION OF OSTEOCLAST (OC) FORMATION, IN AN INVITRO OSTEOCLASTOGENESIS MODEL FROM Pp. WE DEMONSTRATED HIGH LEVELS OF IL7 IN BOTH THE MEDIA COLLECTED FROM PBMC CULTURED OF Pp AND THE SERA OF THE SAME PATIENTS. WE ALSO DEMONSTRATED THAT FRESHLY ISOLATED B CELLS FROM PBMCs OF Pp WERE THE SOURCE OF IL7 IN OUR MODEL. B CELLS, IN FACT, OVEREXPRESSED IL7 AT mRNA AND PROTEIN LEVELS, AND THIS PRODUCTION WAS UP-REGULATED BY IL6. MOREOVER THE OC FORMATION DECREASED IN THE PRESENCE OF ANTI-IL6 AND IL7 FUNCTIONAL ANTIBODIES IN PBMC CULTURES FROM Pp. THESE DATA SUGGEST THAT B CELLS COULD BE RESPONSIBLE FOR THE T CELL-DEPENDENT OSTEOCLASTOGENESIS IN PERIODONTITIS THROUGH THE INVOLVMENT OF IL6 AND IL7.
25. Surgical treatment of gingival overgrowth with 10 years of follow-up
- Author
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Adele Scattarella, Felice Roberto Grassi, Letizia Perillo, Francesco Papa, Angela Dituri, Andrea Ballini, Maria Virginia Bux, Francesco Pettini, Teodoro Romanazzo, Gianna Maria Nardi, Roberto Gianfranco Carlaio, Vito Crincoli, Stefania Cantore, Ballini, A, Scattarella, A, Crincoli, V, Carlaio, Rg, Papa, F, Perillo, Letizia, Romanazzo, T, Bux, Mv, Nardi, Gm, Dituri, A, Cantore, S, Pettini, F, and Grassi, Fr
- Subjects
Adult ,Male ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,Clinical Neurology ,Dentistry ,Oral hygiene ,Lesion ,Gingivitis ,lcsh:RC581-951 ,medicine ,Humans ,General Dentistry ,Gingival Overgrowth ,business.industry ,Dentistry(all) ,Research ,Surgery ,Masticatory force ,Major duodenal papilla ,Treatment Outcome ,Otorhinolaryngology ,Oral and maxillofacial surgery ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Follow-Up Studies ,Gingival margin - Abstract
Background In some pathological conditions, gingivitis caused by plaque accumulation can be more severe, with the result of an overgrowth. Nevertheless, the overgrowth involves the gingival margin with extension to the inter-dental papilla. The lesion may involve the inter-proximal spaces, and become so extensive that the teeth are displaced and their crowns covered. Severe overgrowth may lead to impairment in aesthetic and masticatory functions, requiring surgical excision of the excessive tissue. Aim of this study is to describe an operative protocol for the surgical treatment of localized gingival overgrowth analyzing the surgical technique, times and follow-up. Methods A total of 20 patients were enrolled and underwent initial, non surgical, periodontal treatment and training sessions on home oral hygiene training. The treatment plan involved radical exeresis of the mass followed by positioning of an autograft of connective tissue and keratinized gingiva. Results During 10 years of follow-up, all the grafts appeared well vascularized, aesthetically satisfactory, and without relapse. Conclusions Periodontal examinations, surgical procedures, and dental hygiene with follow-up are an essential part of the treatment protocol. However, additional effort is needed from the patient. Hopefully, the final treatment result makes it all worthwhile.
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26. Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: Role of TRAIL
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Giorgio Mori, Brunetti, G., Colucci, S., Ciccolella, F., Coricciati, M., Pignataro, P., Oranger, A., Ballini, A., Farronato, D., Mastrangelo, F., Tetè, S., Grassi, F. R., Grano, M., Mori, G, Brunetti, G, Colucci, S, Ciccolella, F, Coricciati, M, Pignataro, P, Oranger, A, Ballini, A, Farronato, D, Mastrangelo, Filiberto, S., Tete', Grassi, Fr, and Grano, M.
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Adult ,Male ,Cultured ,Osteoblasts ,Cell Survival ,Cells ,Gene Expression ,Apoptosis ,Middle Aged ,Alkaline Phosphatase ,Bone and Bones ,Collagen Type I ,Calcification ,TNF-Related Apoptosis-Inducing Ligand ,Tumor Necrosis Factor Decoy Receptors ,Calcification, Physiologic ,Humans ,Female ,Physiologic ,Periodontitis ,Cells, Cultured - Abstract
Periodontal disease (Pd) is characterized by extensive alveolar bone loss, that occurs as a consequence of the impairment of the normal bone remodelling. Bone remodelling is regulated by the correct balance between osteoclast and osteoblast formation and activity. Alveolar bone loss could be due to an increased bone resorption by osteoclasts or a decreased bone formation by osteoblasts (OBs) or both. Although the role played by osteoclasts in increasing bone resorption in Pd is already known, the behaviour of OBs in this disease is poorly understood. In the present study we hypothesized that activity and survival of OBs, locally present in alveolar bone of Pd patients, are altered. Thus, we studied the activity and survival of OBs obtained from alveolar bone fragments of Pd patients. The results, obtained in OBs from the patients were compared with those from OBs obtained from healthy donors. We demonstrated that OBs from Pd patients weakly express OB phenotype in respect to the control cells. In particular, the alkaline phosphatase activity and the collagen type I production, as well as the formation of mineralized nodules, typical markers of differentiated OBs, were significantly lower in Pd patients. Interestingly, we also demonstrated that OBs from the patients were more sensitive to the apoptotic effect induced by TNF-related apoptosis-inducing ligand (TRAIL). TRAIL, a member of the TNF superfamily, induces apoptosis by interacting with its death receptors, (DR4, DR5). However, its activity can be modulated by two decoy receptors, DcR1 and DcR2. Thus, the sensitiveness of TRAIL induced apoptosis is determined by the ratio of death and decoy receptor. We demonstrated that OBs from Pd patients showed an imbalanced ratio between death and decoy TRAIL receptors due to the down-regulation of DcR2 expression. Furthermore, the levels of TRAIL in the serum of the same patients were significantly higher than those detected in the controls. In conclusion, we show for the first time that the alveolar bone loss in Pd patients could be due to the increased TRAIL-mediated apoptosis of OBs.
27. Treatment of Peri-Implant Mucositis with Standard of Care and Bioptron Hyperlight Therapy: A Randomized Clinical Trial.
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Nardi GM, Mazur M, Papa G, Petruzzi M, Grassi FR, and Grassi R
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- Hemorrhage, Humans, Pain, Standard of Care, United States, Mucositis therapy, Peri-Implantitis
- Abstract
The aim of this study was to evaluate in a cohort of patients with peri-implant mucositis: (a) the efficacy of professional mechanical debridement therapy assisted using Bioptron Hyperlight Therapy on the reduction in periodontal indexes and (b) the reduction in total oxidative salivary stress. Forty subjects with a diagnosis of peri-implant mucositis were enrolled and randomly assigned to the Study Group (mechanical debridement therapy assisted using Bioptron Hyperlight Therapy) or Control Group (mechanical debridement therapy alone). The study duration was 6 months. Data on plaque index (PI), bleeding on probing (BoP), probing pocket depth (PPD), and pain relief on Visual Analogue Scale (VAS) were recorded at T
0 , T1 (14 days), T2 (1 month), and T3 (6 months). Group differences were assessed using Student's t -test and Pearson's Chi-squared test of homogeneity. PI and PPD decreased in the Study Group at the [T0 ; T1 ] time interval and during the overall time of observation significantly more than in the Control Group; BoP and pain on VAS decreased significantly faster in the Study Group than in the Control Group. Differences in Salivary Antioxidant Test (SAT) changes were not significant at any time interval. Patients' gender and smoking habit were not correlated with the clinical outcomes. Clinical parameters related to peri-implant mucositis significantly improved in the Study Group, which demonstrated the clinical efficacy of the Bioptron Hyperlight Therapy as an adjunct to standard of care for the treatment of peri-implant mucositis. The RCT was registered at the US National Institutes of Health #NCT05307445.- Published
- 2022
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28. Prosthetic rehabilitation of maxillary lateral incisors agenesis using dental mini-implants: a multicenter 10-year follow-up.
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Lacarbonara M, Cazzolla AP, Lacarbonara V, Lo Muzio L, Ciavarella D, Testa NF, Crincoli V, Di Venere D, De Franco A, Tripodi D, Grassi FR, and Capogreco M
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- Dental Implantation, Endosseous, Dental Prosthesis, Implant-Supported, Follow-Up Studies, Humans, Incisor, Maxilla surgery, Alveolar Bone Loss, Dental Implants, Dental Implants, Single-Tooth, Immediate Dental Implant Loading
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Objectives: Implants are used to replace congenitally missing lateral incisors but often the space across the alveolar crest is too narrow to permit their use. This multicenter study (Dental Clinic of the University of Foggia, Odontostomatology Clinic of the University of L'Aquila) evaluated the efficacy of mini-implants in cases of maxillary lateral incisor agenesis with severe osseous atrophy in 10-year follow-up., Materials and Methods: Forty-seven mini-implants have been inserted in 35 patients affected by lateral incisors agenesis (23 single and 12 bilateral ageneses). All patients underwent orthodontic opening of the space of the upper lateral incisors. After the insertion of the implants, the immediate, non-functional loading, positioning of crowns, presence of pain during percussion and mini-implant function, horizontal and vertical movement when a force of 5 N was applied, ridge loss, and plaque index have been evaluated 1 month after loading, 1 year after loading, and then every 5 years in the following 10 years. Little's test was used to evaluate the assumption that data of loss to follow-up implants are missing completely at random (MCAR) and that a complete-case scenario could be adopted. Wilcoxon test was carried out to look statistically significant differences between the various parameters resulting in the complete-case scenario and those assumed for the worst scenario. The software R (v. 3.6.1, 2019) was employed to perform the statistical analysis., Results: The results obtained over 10 years range from 89% of success rate in a worst-case scenario to the 100% using a complete-case analysis with satisfactory values of marginal bone resorption and good conditions of the peri-implant tissue. Ten-year follow-up using complete-case analysis shows survival rates of 100% for implants with no signs of peri-implantitis, stability of the marginal bone levels and soft tissue around the dental implants., Conclusions: The data collected show very good implant stability, absence of progressive peri-implantitis, and satisfactory aesthetical results in time (no signs of infraocclusion)., Clinical Relevance: Mini-implants can be considered a valid and stable over time solution in the restorative treatment of maxillary lateral incisors agenesis., (© 2021. The Author(s).)
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- 2022
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29. How Did the COVID-19 Pandemic Effect Dental Patients? An Italian Observational Survey Study.
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Nardi GM, Grassi R, Grassi FR, Di Giorgio R, Guerra F, Ottolenghi L, Acito G, Basari N, Bisegna S, Chiavistelli L, Cimarossa R, Colavito A, Figlia L, Gabrielli C, Sabatini S, Jedliński M, and Mazur M
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The primary aim of this observational survey study was to assess patients' attitudes toward clinical dental practice during the COVID-19 pandemic; the secondary aim was to evaluate patients' attitudes towards oral health by maintaining an appropriate lifestyle and oral hygiene at home. The questionnaire was developed using Google Forms. The questionnaire consisted of three parts: Part A-geographic, demographic, and personal data; Part B-patients' attitude toward oral health selfcare and lifestyle; Part C-patients' attitude toward dental practice. This survey, conducted during the months of November and December 2020, enrolled 1135 subjects throughout Italy. All data were statistically analyzed. COVID-19 has changed patients' approach to dental procedures. Most of the people interviewed lived in families, and their greatest fear was infecting a family member. Restrictive measures forced people to stay at home, which led to an increased consumption of various types of food, including cariogenic foods. People said they felt safe when they went to the dentist, but they also paid special attention to measures to prevent contagion. Among the measures that should be introduced in similar situations in the future, people wanted telemedicine, a phone recall, and the possible use of video clips for home oral care instructions.
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- 2021
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30. Maternal and Neonatal Oral Microbiome Developmental Patterns and Correlated Factors: A Systematic Review-Does the Apple Fall Close to the Tree?
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Nardi GM, Grassi R, Ndokaj A, Antonioni M, Jedlinski M, Rumi G, Grocholewicz K, Dus-Ilnicka I, Grassi FR, Ottolenghi L, and Mazur M
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- Female, Humans, Infant, Newborn, Overweight, Pregnancy, Trees, Diabetes, Gestational, Malus, Microbiota
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(1) Background: The purpose of the study was to comprehensively analyze the relationship between the mother's oral microbiome, modes of delivery and feeding, and the formation of the newborn child's oral microbiome. (2) Methods: This systematic review included a search through MEDLINE (PubMed) database (from 2010 to July 2020). Research was registered in PROSPERO under the number CRD42021241044. (3) Results: Of the 571 studies, 11 met the inclusion criteria. Included studies were classified according to (i) child's delivery mode, (ii) maternal exposure to antibiotics and disinfectants, and (iii) feeding type. (4) Conclusions: The interpretation of these papers shows that the type of delivery, maternal exposure to disinfectants and antibiotics during delivery, maternal health classed as overweight, gestational diabetes mellitus, and feeding type are correlated to changes in the maternal and neonatal early oral microbiomes, based on the analysis provided in this systematic review. Because no evidence exists regarding the impact of maternal diet and maternal oral health on the establishment and development of the early oral newborn microbiome, more studies are needed to deepen the knowledge and understanding of the subject and develop preventive and therapeutic strategies of support to pregnant women.
- Published
- 2021
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31. Phototherapy and Tailored Brushing Method. Personalized Oral Care in Patients with Facial and Dental Trauma. A Report of a Case.
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Nardi GM, Guerra F, Ndokaj A, Corridore D, Straker MA, Sportelli P, Di Giorgio R, Grassi FR, Grassi R, and Ottolenghi L
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(1) Background: Traumatic dental injuries are frequent in children and young adults. The facial structures involved in dental trauma may include soft tissues of the face and mouth, bone and dental structures. Dental trauma often results in augmented dental anxiety. Phototherapy can improve stress and pain control thereby improving compliance in young patients with the necessary dental treatments, after dental trauma has occurred. (2) Methods: Phototherapy was performed to enable soft tissue healing. The Tailored Brushing Method (TBM), a personalized approach for at-home oral hygiene procedures, was also utilized, with the aim of improving biofilm control in traumatized patients. (3) Results: The approach hereafter presented made it possible to obtain subjective control of anxiety and pain documented on a visual analog scale (VAS) due to the innovative use of photo-biomodulation. In addition, for the first time, the TBM was adapted to the needs of a patient with facial trauma and illustrated. (4) Conclusions: Phototherapy and TBM were found to be effective in the combined treatment of soft tissue wounds and in the oral care of the traumatized patient.
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- 2021
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32. Mouthwash Based on Ozonated Olive Oil in Caries Prevention: A Preliminary In-Vitro Study.
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Nardi GM, Fais S, Casu C, Mazur M, Di Giorgio R, Grassi R, Grassi FR, and Orrù G
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- Humans, Italy, Microbial Sensitivity Tests, Dental Caries prevention & control, Mouthwashes pharmacology, Olive Oil, Streptococcus mutans
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(1) Background: Ozone (O3) proved to oxidize organic and inorganic compounds, and its efficacy against bacteria, viruses and fungi plasma membranes was of interest. Ozone vehicle can be a gaseous form, ozonated water or ozonized oil. The aim of this in-vitro study was to evaluate the efficacy of ozonated olive oil against Streptococcus mutans . (2) Methods: Two different commercial mouthwashes were tested: Ialozon Blu (IB) (Gemavip, Cagliari, Italy), with ozonated olive oil, and Ialozon Rose (IR) (Gemavip, Cagliari, Italy), with ozonated olive oil, hyaluronic acid and vitamin E. All formulates were analyzed in a dilution range from 2- to 256-folds in saline solution, as to reproduce the salivary dilution. Streptococcus mutans CIP103220 strain was used for the antimicrobial susceptibility test, and the Kirby-Bauer inhibition method was performed to evaluate the Minimum Inhibitory (MIC), Minimum Bactericidal (MBC), and Minimum Biofilm Inhibitory Concentration (MBIC). (3) Results: Both formulates showed the same antimicrobial activity. MIC, MBC, and MBIC were observed for dilution factors of 1/32, 1/8 and 1/8, respectively. The mean value of inhibition zone diameter was 16.5 mm for IB, and 18 mm for IR. (4) Conclusions: The results suggested that ozonized olive oil formulates were able to inactivate Streptococcus mutans avoiding the salivary dilution effect in the oral cavity.
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- 2020
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33. Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial.
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Nardi GM, Cesarano F, Papa G, Chiavistelli L, Ardan R, Jedlinski M, Mazur M, Grassi R, and Grassi FR
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- Follow-Up Studies, Humans, Root Planing, Matrix Metalloproteinase 8, Mouthwashes therapeutic use, Olive Oil, Periodontal Index
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Background : Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods : Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student's t -test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone.
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- 2020
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34. The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial.
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Rapone B, Ferrara E, Corsalini M, Converti I, Grassi FR, Santacroce L, Topi S, Gnoni A, Scacco S, Scarano A, and Delvecchio M
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- Adult, Aged, Blood Glucose, Humans, Middle Aged, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 therapy, Glycated Hemoglobin analysis, Ozone therapeutic use, Periodontal Diseases complications, Periodontal Diseases therapy
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Background: It is established that inflammation is involved in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) by promoting insulin resistance and impaired beta cell function in the pancreas. Among the hypothesized independent risk factors implicated in the pathogenetic basis of disease, periodontal infection has been proposed to promote an amplification of the magnitude of the advanced glycation end product (AGE)-mediated upregulation of cytokine synthesis and secretion. These findings suggest an interrelationship between periodontal disease and type 2 diabetes, describing poor metabolic control in subjects with periodontitis as compared to nondiabetic subjects and more severe periodontitis in subjects with T2DM as compared to a healthy population, with a significant positive correlation between periodontal inflammatory parameters and glycated hemoglobin level. Results from clinical trials show that periodontal treatment is able to improve glycemic control in subjects with diabetes. Many therapeutic strategies have been developed to improve periodontal conditions in conjunction with conventional treatment, among which ozone (O
3 ) is of specific concern. The principal aim of this trial was to compare the clinical effectiveness of an intensive periodontal intervention consisting of conventional periodontal treatment in conjunction with ozone gas therapy in reducing glycated hemoglobin level in type 2 diabetic patients and standard periodontal treatment., Methods: This study was a 12-month unmasked randomized trial and included 100 patients aged 40-74 years older, with type 2 diabetes mellitus diagnosed. All the patients received conventional periodontal treatment, or periodontal treatment in conjunction with ozone gas therapy in a randomly assigned order (1:1). The primary outcome was a clinical measure of glycated hemoglobin level at 3, 6, 9 and 12 months from randomization. Secondary outcomes were changes in periodontal inflammatory parameters., Results: At 12 months, the periodontal treatment in conjunction with ozone gas therapy did not show significant differences than standard therapy in decreasing glycated hemoglobin (HbA1C) level and the lack of significant differences in balance is evident., Conclusions: Although the change was not significant, periodontal treatment in conjunction with the gaseous ozone therapy tended to reduce the levels of glycated hemoglobin. The study shows a benefit with ozone therapy as compared to traditional periodontal treatment.- Published
- 2020
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35. Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal®.
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Di Benedetto A, Posa F, Marazzi M, Kalemaj Z, Grassi R, Lo Muzio L, Comite MD, Cavalcanti-Adam EA, Grassi FR, and Mori G
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- Cartilage, Articular drug effects, Chondrocytes drug effects, Humans, Hyaluronic Acid chemistry, Lysine chemistry, Mesenchymal Stem Cells drug effects, Sodium Chloride chemistry, Thymine chemistry, Tissue Engineering, Cartilage, Articular cytology, Cell Differentiation, Chondrocytes cytology, Chondrogenesis, Lysine pharmacology, Mesenchymal Stem Cells cytology, Osteogenesis, Sodium Chloride pharmacology, Thymine pharmacology
- Abstract
Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior stability, has already been proved efficient in repairing corneal epithelial cells damaged by dry conditions in vitro . We investigated the regenerative potential of T-Lys in the hard tissues bone and cartilage. We have previously demonstrated that cells isolated from the tooth germ, Dental Bud Stem Cells (DBSCs), differentiate into osteoblast-like cells, representing a promising source of MSCs for bone regeneration. Herewith, we show that T-Lys treatment stimulates the expression of typical osteoblastic markers, such as Runx-2, Collagen I ( Col1 ) and Alkaline Phosphatase (ALP), determining a higher production of mineralized matrix nodules. In addition, we found that T-Lys treatment positively affects α
V β3 integrin expression, key integrin in the osteoblastic commitment, leading to the formation of focal adhesions (FAs). The efficacy of T-Lys was also tested on chondrogenic differentiation starting from human articular chondrocytes (HACs) resulting in an increase of differentiation markers and cell number., (Copyright © 2020 Di Benedetto, Posa, Marazzi, Kalemaj, Grassi, Lo Muzio, Comite, Cavalcanti-Adam, Grassi and Mori.)- Published
- 2020
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36. Does Diabetes Induce the Vascular Endothelial Growth Factor (VEGF) Expression in Periodontal Tissues? A Systematic Review.
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Nardi GM, Ferrara E, Converti I, Cesarano F, Scacco S, Grassi R, Gnoni A, Grassi FR, and Rapone B
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- Case-Control Studies, Gingival Crevicular Fluid metabolism, Humans, Periodontitis metabolism, Diabetes Mellitus pathology, Periodontium metabolism, Vascular Endothelial Growth Factor A metabolism
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Aim: Diabetes and periodontal disease are both chronic pathological conditions linked by several underlying biological mechanisms, in which the inflammatory response plays a critical role, and their association has been largely recognized. Recently, attention has been given to diabetes as an important mediator of vascular endothelial growth factor (VEGF) overexpression in periodontal tissues, by virtue of its ability to affect microvasculature. This review aims to summarize the findings from studies that explored VEGF expression in diabetic patients with periodontitis, compared to periodontally healthy subjects., Materials and Methods: A systematic literature review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A PubMed search of select medical subject heading (MeSH) terms was carried out to identify all studies reporting findings about VEGF expression in periodontal tissues of diabetic patients up to May 2018. The inclusion criteria were studies on VEGF expression in periodontally diseased tissues of diabetic patients compared with nondiabetic subjects, with any method of analysis, and published in the English language., Results: Eight articles met the inclusion criteria. Immunohistochemistry was used in six of the studies, reverse transcriptase polymerase chain reaction (real-time RT-PCR) aiming to quantify mRNA VEGF expression was used in one study, and ELISA analysis was used for one study. Compared with nondiabetic patients, a higher VEGF expression in gingival tissue and gingival crevicular fluid (GCF) samples in diabetic patients with periodontitis was reported., Conclusions: Overall, novel evidence for the VEGF expression within the periodontal tissue of diabetic patients paves the way for further studies on the role of this protein in neovascularization physiology and pathophysiology in microvasculature of the periodontium.
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- 2020
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37. Design Techniques to Optimize the Scaffold Performance: Freeze-dried Bone Custom-made Allografts for Maxillary Alveolar Horizontal Ridge Augmentation.
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Grassi FR, Grassi R, Vivarelli L, Dallari D, Govoni M, Nardi GM, Kalemaj Z, and Ballini A
- Abstract
The purpose of the current investigation was to evaluate the clinical success of horizontal ridge augmentation in severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from the tibial hemiplateau of cadaver donors, and to analyze the marginal bone level gain prior to dental implant placement at nine months subsequent to bone grafting and before prosthetic rehabilitation. A 52-year-old woman received custom made bone grafts. The patient underwent CT scans two weeks prior and nine months after surgery for graft volume and density analysis. The clinical and radiographic bone observations showed a very low rate of resorption after bone graft and implant placement. The custom-made allograft material was a highly effective modality for restoring the alveolar horizontal ridge, resulting in a reduction of the need to obtain autogenous bone from a secondary site with predictable procedure. Further studies are needed to investigate its behavior at longer time periods.
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- 2020
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38. Dimensional changes of buccal bone plate in immediate implants inserted through open flap, open flap and bone grafting and flapless techniques: A cone-beam computed tomography randomized controlled clinical trial.
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Grassi FR, Grassi R, Rapone B, Alemanno G, Balena A, and Kalemaj Z
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- Bone Plates, Bone Transplantation, Cone-Beam Computed Tomography, Humans, Tooth Socket, Alveolar Bone Loss, Dental Implants, Single-Tooth
- Abstract
Objectives: To assess through cone-beam computed tomography (CBCT) buccal alveolar bone alterations after immediate implant placement using the following techniques: open flap and grafting (flap-graft), open flap and no grafting (flap-nograft) and flapless and no grafting (noflap-nograft)., Materials and Methods: This was a three-armed parallel group randomized clinical trial with allocation ratio 1:1:1. Patients were eligible in case they needed immediate implant replacing teeth in maxillary premolar area, with sufficient buccal bone support. CBCT was performed immediately after the intervention and 6 months later. The main outcomes were CBCT measurements performed at apical (A-EA), medial (M-EM) and external and internal implant bevel level (B-EB, B-IB) and vertical defect depth (DP). Pain and discomfort, time of surgery and complications were recorded. Differences between groups were estimated through ANOVA tests and post-hoc Scheffe's analysis for pairwise comparisons. Multiple regressions were conducted to estimate influence of gingival biotype and baseline marginal gap dimension., Results: Forty-five patients were recruited and randomized to treatments with one lost to follow-up. Analysis of variance showed that the effect of treatment technique was not relevant for all horizontal and vertical outcomes. The three techniques exhibited almost complete fill of marginal gap, with a mean residual vertical gap of 0.27 mm and horizontal gap of 0.5 mm. Regression models indicated a positive effect of thick biotype on gap filling and dimensional bone reduction. The noflap-nograft technique resulted less painful., Conclusions: The option of noflap-nograft surgery in post-extraction implants allows for minimal surgical intervention with comparable buccal bone changes and gap filling after a follow-up of 6 months in sites with sufficient buccal bone support., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2019
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39. Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients.
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Rapone B, Converti I, Santacroce L, Cesarano F, Vecchiet F, Cacchio L, Scacco S, Grassi R, Grassi FR, Gnoni A, and Nardi GM
- Abstract
Background : Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim : The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods : The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results : At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS., Competing Interests: The authors declare no conflict of interest related to this study.
- Published
- 2019
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40. Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study.
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Petruzzi M, Della Vella F, Cassandro A, Mosca A, Di Comite M, Contaldo M, Grassi FR, and Lauritano D
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- Adult, Aged, Biopsy, Candida metabolism, Candidiasis, Oral microbiology, Female, Fluorescence, Humans, Male, Middle Aged, Porphyrins metabolism, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Tongue microbiology, Candida isolation & purification, Candidiasis, Oral diagnosis, Molecular Imaging methods, Optical Imaging methods, Porphyrins chemistry, Tongue diagnostic imaging
- Abstract
Aim: To investigate the correlation between the dorsal tongue porphyrin autofluorescence, revealed using VELscope, and Candida saprophytism., Material and Methods: Consecutive patients underwent an autofluorescence examination by the VELscope device to establish the presence or absence of porphyrin fluorescence. A tongue swab was collected for the Candida cultural test. Sensitivity, specificity, accuracy, negative predictive value and positive predictive value were calculated considering the oral swab as the gold standard. The degree of agreement between the two tests was calculated using Cohen's K coefficient., Results: One hundred twenty-six patients were enrolled. Porphyrin fluorescence method showed a sensitivity of 78%, specificity of 76% and an accuracy of 78%. Negative predictive value and positive predictive value were respectively 90% and 59%. The strength of agreement between the two methods resulted to be moderate (k = 0.551)., Conclusions: Off-label use of tongue autofluorescence examination to detect the presence of Candida species is characterized by a loss of porphyrin fluorescence. The high negative predictive value of porphyrin fluorescence loss suggests its use in preliminary selection of Candida carriers, in order to plan preventive and therapeutic strategies., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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41. Periodontal Microbiological Status Influences the Occurrence of Cyclosporine-A and Tacrolimus-Induced Gingival Overgrowth.
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Rapone B, Ferrara E, Santacroce L, Cesarano F, Arazzi M, Liberato LD, Scacco S, Grassi R, Grassi FR, Gnoni A, and Nardi GM
- Abstract
Immune suppressed renal transplant patients are more prone to developing oral tissue alterations due to medications associated with a pleiotropic set of side effects involving the oral cavity. Drug-induced gingival overgrowth (DIGO) is the most commonly encountered side effect resulting from administration of calcineurin inhibitors such as cyclosporine-A (CsA), the standard first-line treatment for graft rejection prevention in transplant patients. Pathogenesis of gingival overgrowth (GO) is determined by the interrelation between medications and a pre-existing inflammatory periodontal condition, the main modifiable risk factor. Severity of gingival hyperplasia clinical manifestation is also related to calcium channel blocker association, frequently provided in addition to pharmacological therapy of transplant recipients. Specifically, nifedipine-induced enlargements have a higher prevalence rate compared to amlodipine-induced enlargements; 47.8% and 3.3% respectively. Available epidemiological data show a gender difference in prevalence, whereby males are generally more frequently affected than females. The impact of GO on the well-being of an individual is significant, often leading to complications related to masticatory function and phonation, a side effect that may necessitate switching to the tacrolimus drug that, under a similar regimen, is associated with a low incidence of gingival lesion. Early detection and management of GO is imperative to allow patients to continue life-prolonging therapy with minimal morbidity. The purpose of this study was threefold: firstly, to determine the prevalence and incidence of GO under the administration of CsA and Tacrolimus; secondly, to assess the correlation between periodontal status before and after periodontal therapy and medications on progression or recurrence of DIGO; and finally, to analyse the effect of immunosuppressant in association to the channel blocker agents on the onset and progression of gingival enlargement. We compared seventy-two renal transplant patients, including 33 patients who were receiving CsA, of which 25% were also receiving nifedipine and 9.72% also receiving amlodipine, and 39 patients who were receiving tacrolimus, of which 37.5% were also receiving nifedipine and 5.55% also receiving amlodipine, aged between 35 and 60 years. Medical and pharmacological data were recorded for all patients. Clinical periodontal examination, in order to establish the inflammatory status and degree of gingival enlargement, was performed at baseline (T0), 3 months (T1), 6 months (T2), and 9 months (T3). All patients were subjected to periodontal treatment. Statistically significant correlation between the reduction of the mean value of periodontal indices and degree of gingival hyperplasia at the three times was revealed. The prevalence of GO in patients taking cyclosporine was higher (33.3%) in comparison with those taking tacrolimus (14.7%). In accordance with previous studies, this trial highlighted the clinical significance of the pathological substrate on stimulating drug-induced gingival lesion, confirming the key role of periodontal inflammation in pathogenesis of gingival enlargement, but did not confirm the additional effect of calcium-channel blocker drugs in inducing gingival enlargement., Competing Interests: The authors declare no conflict of interest related to this study.
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- 2019
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42. Polarized Polychromatic Noncoherent Light (Bioptron Light) as Adjunctive Treatment in Chronic Oral Mucosal Pain: A Pilot Study.
- Author
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Petruzzi M, Nardi GM, Cocco F, Della Vella F, Grassi R, and Grassi FR
- Subjects
- Adult, Aged, Chronic Pain drug therapy, Facial Pain drug therapy, Female, Humans, Male, Middle Aged, Pain Measurement, Pilot Projects, Symptom Assessment, Chronic Pain therapy, Facial Pain therapy, Phototherapy methods
- Abstract
Objective: Aim of this study was to assess the efficacy of polarized polychromatic noncoherent light (Bioptron light) in the treatment of chronic oral mucosal pain (COMP). Patients and methods: Twenty-two patients affected by COMP were treated with standardized pharmacological protocols in association with Bioptron light (90 W; light wavelength = 480-3400 nm; degree of polarization = 95%; specific power density = 40 mW/cm
2 ; energy density = 2.4 J/cm). The outcome measures were intensity of pain [measured by visual analog scale (VAS) score] and signs reduction (measured by Eisen score) recorded at baseline ( t0 ), after 4 weeks ( t1 ), and after 8 weeks ( t2 ). Signs and symptoms scores were compared with those of a cohort of comparable patients selected from institutional medical record files. Results: Patients in pharmacological treatment associated with Bioptron showed a significant VAS score decrease at t1 and t2 ( t0 = 6.9, t1 = 3.9, t2 = 1.8, p < 0.05), whereas the patients in exclusive pharmacological treatment showed a significant VAS score improvement only at t2 . Comparing the VAS score at t1 and t2 in the two groups, a significant improvement was recorded in patients undergoing Bioptron adjunctive treatment ( t1 = 3.9 vs. 5.9; p < 0.05 and t2 = 1.8 vs. 3.6; p < 0.05). In both groups Eisen score improved at t1 and t2 , but in the Bioptron-treated patients the improvement was statistically better at t1 (1.9 vs. 0.8; p < 0.05) and at t2 (2.7 vs. 1.4; p < 0.05). Conclusions: In COMP patients, Bioptron use associated with pharmacological treatment allows a better and faster signs and symptoms reduction when compared with the exclusive pharmacological treatment. Further controlled studies are needed to establish the relative and absolute effectiveness of Bioptron in COMP management.- Published
- 2019
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43. Use of photobiomodulation induced by polarized polychromatic non-coherent light in the management of adult chronic periodontitis.
- Author
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Nardi GM, Grassi R, Grassi FR, Aragona SE, Rapone B, Della Vella F, and Sabatini S
- Subjects
- Adult, Humans, Light, Chronic Periodontitis therapy, Phototherapy
- Published
- 2019
44. Obstructive site localization in patients with Obstructive Sleep Apnea Syndrome: a comparison between otolaryngologic data and cephalometric values.
- Author
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DI Venere D, Corsalini M, Nardi GM, Laforgia A, Grassi FR, Rapone B, and Pettini F
- Abstract
Purpose: Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory disorder characterized by repeated obstructive episodes affecting upper airways.This study aims at examining the anatomical craniofacial and pharyngeal characteristics of the patient as to identify the obstructive site which triggers the pathologic process.Correlations between otolaryngologic data observed in the patient and the cephalometric ones for the identification of the obstructive site were also highlighted., Materials and Methods: We worked on a sample of 16 patients, 12 males and 4 females, attended to at the Otolaryngology Operative Unit of Bari University Hospital.The patients underwent an otolaryngologic (ORL) diagnostic procedure which provided for ApneaGraph (AG) recording, and a dental diagnostic procedure with cephalometric assessment., Results: The statistical analysis highlighted a strict correlation between the otolaryngologic value of AHI and the cephalometric values of the ANB angle, with the distance between the hyoid bone and the mandibular plane and with the distance between the hyoid bone and the plane passing between C3 and Me., Conclusions: We observed a concurrence between the ORL diagnosis of the obstruction level assessed with AG and the cephalometric values regarding respiratory tracts (IPAS and SAS). More precisely, we observed the correlation between the otolaryngologic value of AHI with cephalometric values of the ANB angle, with the distance between hyoid bone and mandibular plan, and with the distance between the hyoid bone and the plane passing between C3 and Me. Furthermore, the identification of the caudal position of the hyoid bone can be considered an alarm bell in the diagnosis of severe OSAS.
- Published
- 2017
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45. Early mandibular canine-lateral incisor transposition: case report.
- Author
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DI Venere D, Nardi GM, Lacarbonara V, Laforgia A, Stefanachi G, Corsalini M, Grassi FR, Rapone B, and Pettini F
- Abstract
Purpose: The main aim of the present study is to present a case of mandibular transposition between lateral incisor and canine in a paediatric patient., Materials and Methods: A fixed multibracket orthodontic treatment was performed by means of a modified welded arch as to correct the transposition and obtaining a class I functional and symmetrical occlusion, also thanks to the early diagnosis of the eruption anomaly., Results: Our case report shows that a satisfactory treatment of mandibular transpositions is obtained when detected at an early stage of the tooth development., Conclusions: The main treatment options to be taken into consideration in case of a mandibular transposition are two: correcting the transposition or aligning it leaving the dental elements in their transposed order; in both cases, the follow-ups show a stable condition, maintained without relapses. Several factors, such as age of the patient, occlusion, aesthetics, patient's collaboration, periodontal support and duration of treatment have to be considered as to prevent potential damage to dental elements and support appliances. The choice between the two treatment approaches for mandibular lateral incisor/canine transpositions mainly depends on the time the anomaly is detected.
- Published
- 2017
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46. Immediately Loaded, Implant-Supported Overdentures Retained by a Milled Bar: An Up-to-5-Year Retrospective Clinical Study.
- Author
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Villa F, Grassi FR, Popovic M, Sordillo R, and Kalemaj Z
- Subjects
- Aged, Alveolar Bone Loss epidemiology, Alveolar Bone Loss pathology, Dental Restoration Failure statistics & numerical data, Denture Retention methods, Female, Humans, Male, Middle Aged, Retrospective Studies, Dental Prosthesis, Implant-Supported adverse effects, Dental Prosthesis, Implant-Supported methods, Denture, Overlay adverse effects, Immediate Dental Implant Loading adverse effects
- Abstract
This study was conducted as an up-to-5-year retrospective investigation estimating survival rate, marginal bone loss (MBL), patient satisfaction, complications, and required prosthodontic maintenance for immediately loaded, milled bar-retained, implant-supported overdentures (ISOs). A total of 60 patients, 69 overdentures, and 179 implants were examined. The implant survival rate was 96.65%, and the mean MBL was 0.57 mm (SD 0.52). High subjective satisfaction ratings, ranging from 3 to 5 with a mean of 4.3 (SD 0.6), were observed. The incidence of complications and prosthetic maintenance was low and required short standard appointments. The present findings encourage the use of immediately loaded, milled bar-retained ISOs.
- Published
- 2017
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47. Correlation between parodontal indexes and orthodontic retainers: prospective study in a group of 16 patients.
- Author
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DI Venere D, Pettini F, Nardi GM, Laforgia A, Stefanachi G, Notaro V, Rapone B, Grassi FR, and Corsalini M
- Abstract
Purpose: Fixed retainers are used to stabilize dental elements after orthodontic treatment. Being it a permanent treatment, it is necessary to instruct patients about a constant and continuous monitoring of their periodontal conditions and a correct oral hygiene. The aim of this study was to highlight the possible adverse effects of bonded retainers on parameters correlated to the health conditions of periodontal tissues., Materials and Methods: We selected 16 patients, under treatment in the Orthodontics Department of University of Bari Dental School, who had undergone a lingual retainer insertion at the end of the orthodontic treatment. The patients were then divided into two groups (Control Group and Study Group) and monitored for 3 and 36 months, respectively. The following indexes were taken into consideration: gingival index (GI), plaque index (PI) and the presence of calculus (Calculus Index, CI), the probing depth and the presence of gingival recession on the six inferior frontal dental elements., Results: After the observation was carried out, any of the patients showed periodontal sockets and gingival recession. In the Study Group, only 1 patient had a PI score=3, the 7 left had scores between 0.66 and 2.83. In the Control Group, one patient had score=0, the other ones showed values between 0.5 and 1.66. The mean GI in the Study Group peaked at a score of 2.83, the minimum was 0.66; whereas in the Control Group the maximum value was 2 and the minimum 0.66. The CI in the Group Study was between 1 and 2. In the Control Group it was absent in only 1 patient, whereas in the remaining 7, it had a value between 0.3 and 1. The clinical data were studied by means of the Wilcoxon test. We found a statistically significant difference for what concerns the Plaque Indexes (PI) (P>0.05) and Calculus Indexes (CI) (P>0.1) in both groups, with higher scores in the Study Group, having retainers for 36 months. Any statistically significant difference was calculated for the GI., Conclusions: We can therefore conclude that patients with lingual retainers need periodontal hygiene and treatment as to prevent, in the course of time, periodontal damages non-detectable in short-term.
- Published
- 2017
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48. Photobiomodulation with polarized light in the treatment of cutaneous and mucosal ulcerative lesions.
- Author
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Aragona SE, Grassi FR, Nardi G, Lotti J, Mereghetti G, Canavesi E, Equizi E, Puccio AM, and Lotti T
- Abstract
In recent decades, regenerative medicine has achieved an important evolution at both a conceptual level and scientific production, which explains the current and future possibilities of therapy and daily clinical practice. The main aim of regenerative medicine is the complex system of repair/regeneration. The current literature on the subject demonstrates the advantage of visible light therapy for skin injuries and diseases with the photobiomodulation in which light at low energy levels modulates intra- and extra-cellular photoreceptors by molecular and cellular processes that can stimulate both anti-inflammatory mechanisms and cell proliferative response. The irradiation effects are activated soon after exposure. The anti-inflammatory action on some classes of cytokines and cells (e.g. mast cells and macrophages) is completed with the stimulation of the nitric oxide production, which has an anti-inflammatory and vasodilation action, and gives analgesic relief. Our attention focused on photobiomodulator medical device emitting polarized light. 30 patients (19 women and 11 men) were enrolled in the present study. They were treated for chronic lesions using Bioptron® Light Therapy System device. Patients were initially subjected to Bioptron® light for 20 min after cleansing of the lesion. The operating protocol provides 24 sessions: twice per week for 12 weeks. Twenty patients have been studied for symptoms, histological samples and ulcer characteristics. After 2 months, a reduction of 50% of the lesions was recorded in 18 patients (60%), while in the remaining patients a slower healing was observed. The total wound healing was achieved after 3 months in 13 patients (43%). The examined parameters of the symptom were exudation, pain and signs of infection. Results at 1 and 3 months were, Exudation: at 1 month reduction and positive modulation was observed in 16 patients (53%) and in 25 patients at 3 months; Pain: (evaluated with Vas scale), decreased in 21 patients at 1 month (70%) and in 100% of cases at 3 months; Infections: regressed or disappeared in 100% of cases after the first month. Today, it is no longer time for monotherapy applications, especially in regenerative medicine and the adoption of biophysical therapies can play a positive anti-inflammatory and regenerative role enhancing the function of non-invasive therapies.
- Published
- 2017
49. Oral hygiene in patients with oral cancer undergoing chemotherapy and/or radiotherapy after prosthesis rehabilitation: protocol proposal.
- Author
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Rapone B, Nardi GM, DI Venere D, Pettini F, Grassi FR, and Corsalini M
- Abstract
Purpose: This study was aimed at assessing the effectiveness and the importance of an oral hygiene (OH) protocol in patients undergoing radiation therapy and chemotherapy after prosthesis rehabilitation, in order to reduce or minimize oral complications., Materials and Methods: This study was carried out at the Department of Dental Science, at the University of Bari-Italy from December 2012 to December 2015 on 34 selected patients with primary oral cancer undergoing chemotherapy and radiotherapy after prosthesis rehabilitation. They were divided into 2 groups according to their age, sex and cancer therapy. Seventeen patients were assigned to the control group and seventeen in the experimental one. In the experimental group (Table 1), patients underwent an oral hygiene protocol whereas in the control group (Table 2) patients received the usual care provided within the clinical setting. All the patients gave written informed consent. It has been asked and obtained the authorisation from the Ethics Committee of the Dental Science and Surgery Department., Results: Results show that in patients undergoing the oral hygiene protocol, the complications and the risks of infection and permanent dental problems have been minimized. Indeed, of the seventeen patients undergoing the OH protocol, 70% obtained positive results and were satisfied with the program outcome., Conclusions: The role of the health care providers is essential to educate patients to adhere to the prescribed treatments and reinforce their motivation in oral hygiene. The oral hygiene procedures prevent and ameliorate oral complications due to the radiation therapy and chemotherapy.
- Published
- 2017
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50. Effectiveness of computer-assisted anesthetic delivery system (sta ™ ) in dental implant surgery: a prospective study.
- Author
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Grassi FR, Rapone B, Scarano Catanzaro F, Corsalini M, and Kalemaj Z
- Abstract
Objectives: This prospective cohort study aimed to investigate effectiveness of Computerized Local Anesthesia (CLA) on oral implantology through estimation of pain and discomfort and total quantity of injected anesthetic., Methods: Forty-five consecutive patients whose treatment plan included immediate or late dental implants were included in this study. The main inclusion criteria comprised: previous implant intervention under conventional anesthesia (CA) during the past 3 years and no previous treatment of pain relief. All patients reported on a 0-10 scale on previous experience with CA, and new experience with CLA. The same CLA system, namely Single Tooth Anesthesia (STA) was used for all patients with half of the quantity normally used for CA. Data on quantity of anesthetic and reported ratings were collected and described. Potential associations and determinant variables were analysed through correlation analysis and regression models., Results: Out of 45 patients, 27 received post-extractive implant surgery whereas the rest 18 implant surgery on healed sites. The reported pain from STA (mean 1.6, SD 0.7) showed important difference as compared to CA (7.9, SD 1.2; z=5.873; p<0.0001). The comfort perceived during the STA ranged from 7 to 10 (mean 9.5, SD 0.79). A second injection with half of the initial dose was necessary in three cases only., Conclusions: STA system proved to be effective during interventions of dental implantology, by markedly reducing patients' pain and discomfort and the total quantity of necessary anesthetic., Competing Interests: Conflicts of interest The Authors declare that no conflicts of interest exist.
- Published
- 2017
- Full Text
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