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298 results on '"Gurevich K"'

1. Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Author

Igrunkova A, Fayzullin A, Churbanov S, Shevchenko P, Serejnikova N, Chepelova N, Pahomov D, Blinova E, Mikaelyan K, Zaborova V, Gurevich K, Urakov A, Vanin A, Timashev P, and Shekhter A

Subjects
wound, infection, drug, resistence, search and development, nitric oxide, spray, healing, Therapeutics. Pharmacology, RM1-950
Abstract

Alexandra Igrunkova,1,2 Alexey Fayzullin,1,2 Semyon Churbanov,1 Polina Shevchenko,1 Natalia Serejnikova,1,2 Natalia Chepelova,1,2 Dmitry Pahomov,3 Ekaterina Blinova,4 Karen Mikaelyan,1 Victoria Zaborova,5,6 Konstantin Gurevich,7 Aleksandr Urakov,8,9 Anatoly Vanin,1 Peter Timashev,1,2,10 Anatoly Shekhter1 1Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation; 2World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, Moscow, Russian Federation; 3Department of Operative Surgery and Topographic Anatomy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; 4Department of Faculty Surgery, Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russian Federation; 5Institute of Clinical Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation; 6Laboratory of Sports Adaptology, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russian Federation; 7UNESCO Chair “Healthy life style for sustainable development”, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; 8Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Izhevsk City, Udmurt Republic, Russian Federation; 9Department of Modeling and Synthesis of Technological Processes, Institute of Applied Mechanics, Udmurt Federal Research Center of the Ural Branch of the Russian Academy of Sciences, Izhevsk City, Udmurt Republic, Russian Federation; 10Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian FederationCorrespondence: Aleksandr Urakov, Department of General and Clinical Pharmacology, Izhevsk State Medical Academy, Kommunarov str., 281, Izhevsk City, Udmurt Republic, 426034, Russian Federation, Tel +011 79127600939, Email urakoval@live.ruBackground: Ditrosyl iron complexes (DNIC) are endogenous donors of nitric oxide. The possibility of their application to stimulate regeneration has been studied for more than 15 years. However, the most effective dose and form of delivery have not yet been determined.Purpose: The aim of this research was to develop a spray form of DNIC that accelerates wound healing.Methods: We prepared a series of DNIC sprays with spray dosages of 10, 50 and 100 μg. We modelled full-thickness skin wounds in 24 Wistar rats and treated them with distilled water (n = 6), 10 (n = 6), 50 (n = 6) and 100 μg (n = 6) for three post-operative days. On the fourth day, the excised wound tissues were studied by morphological, immunohistochemical and morphometric methods.Results: We demonstrated that 50 μg of DNIC spray had the most beneficial effect on wound healing: the thickness of the granulation tissue layer was 140% higher, vimentin positive fibroblasts predominated and the intensity of inflammation was significantly lower than in the control. There was a dose-dependent decrease in the functional activity of mast cells in the experimental groups compared to the control.Conclusion: DNIC spray is a potential effective dosage form for the treatment of large-area skin lesions.Graphical Abstract: Keywords: wound, infection, drug, resistance, research and development, nitric oxide, spray, healing

Published
2022

2. Effective support, Dirac combs, and signal recovery

Author

Garza, G., Gurevich, K., Iosevich, A., Mayeli, A., Nguyen, K., and Shaffer, N.

Subjects
Mathematics - Classical Analysis and ODEs, Mathematics - Combinatorics, 42B10
Abstract

Let $f: {\mathbb Z}_N^d \to {\mathbb C}$ be a signal with the Fourier transform $\widehat{f}: \Bbb Z_N^d\to \Bbb C$. A classical result due to Matolcsi and Szucs (\cite{MS73}), and, independently, to Donoho and Stark (\cite{DS89}) states if a subset of frequencies ${\{\widehat{f}(m)\}}_{m \in S}$ of $f$ are unobserved due to noise or other interference, then $f$ can be recovered exactly and uniquely provided that $$ |E| \cdot |S|<\frac{N^d}{2},$$ where $E$ is the support of $f$, i.e., $E=\{x \in {\mathbb Z}_N^d: f(x) \not=0\}$. In this paper, we consider signals that are Dirac combs of complexity $\gamma$, meaning they have the form $f(x)=\sum_{i=1}^{\gamma} a_i 1_{A_i}(x)$, where the sets $A_i \subset {\mathbb Z}_N^d$ are disjoint, $a_i$ are complex numbers, and $\gamma \leq N^d$. We will define the concept of effective support of these signals and show that if $\gamma$ is not too large, a good recovery condition can be obtained by pigeonholing under additional reasonable assumptions on the distribution of values. Our approach produces a non-trivial uncertainty principle and a signal recovery condition in many situations when the support of the function is too large to apply the classical theory.

Published
2024

14. Risk factors and attitude to a healthy lifestyle among employees of Russian Railways JSC.

Author

Zhidkova, E. A. and Gurevich, K. G.

Subjects
*OCCUPATIONAL diseases, *FULL-time employment, *FOOD habits, *BODY mass index, *OVERWEIGHT men, *VODKA
Abstract

Relevance. Formation of a healthy lifestyle of the population, the control of non-communicable diseases and prevention is one of the most important tasks of the Russian Federation. Purpose. Identification of risk factors that increase the likelihood of developing chronic non-communicable diseases in employees of Russian Railways JSC. Materials and Methods. The total volume of the online survey is 25,810 people or 3 % of the full-time number of employees. The survey dates: January-February of 2021. A quota sample was used to select respondents. Quotas were carried out according to the following criteria: territorial affiliation, functional branches, categories of employees. The data underwent the procedure of "weighing" (the number of employees of railways, functional branches, representatives of female and male, different age categories). Results. Only 9 % of respondents fully meet the criteria for maintaining a healthy lifestyle. According to the body mass index criterion, 44 % of overweight and obese men were identified. The prevalence of obesity and overweight among men is 1.5 times higher than among women. Men are less focused on healthy eating than women. Managers and specialists observe the principles of healthy nutrition more than other categories of employees. Employees are characterized by the lowest number of persons with a sufficient level of physical activity. No gender differences were found, although there is a tendency that a sufficient level of physical activity is more common in men than in women. Smoking is more common in men than in women. Workers smoke more often than other categories of employees of Russian Railways JSC. Employees are less likely than other categories of employees do not drink alcohol. Women are more likely than men do not drink alcohol. Conclusion. The data obtained by the results of the conducted sociological research indicate the need to promote the values and practices of a healthy lifestyle in the divisions of Russian Railways JSC. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Design of Nanosomal Form of Aprotinin

Author

Kulikov, O. A., Pyataev, N. A., Zaborovskii, A. V., Maev, I. V., Ageev, V. P., Marochkina, E. E., Dolgacheva, I. S., Avdyushkina, I. S., Kokorev, A. V., Gurevich, K. G., Tatarina, L. A., and Yunina, D. V.

Published
2017
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33. Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

Author

Gurevich, K. G., primary, Urakov, A. L., additional, Basantsev, A. V., additional, Abzalilov, T. A., additional, Bashirov, I. I., additional, Danilin, A. A., additional, Purygin, P. P., additional, Golovanov, A. A., additional, Khayrzamanova, K. A., additional, and Samorodov, A. V., additional

Published
2021
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48. Experience of application of specialized food product of dietary therapeutic and dietary preventive nutrition in case of inflammatory diseases of gastrointestinal tract

Author

Pilat, T. L., primary, Kuzmina, L. P., additional, Lashina, E. L., additional, Kolyaskina, M. M., additional, Bezrukavnikova, L. M., additional, Bessonov, V. V., additional, Korosteleva, M. M., additional, Gurevich, K. G., additional, Lagutina, N. P., additional, and Khanferyan, R. A., additional

Published
2020
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