190 results on '"Gynecological disease"'
Search Results
2. Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis
- Author
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Ziwei Zhou, Yifei Feng, Lishan Xie, Song Ma, Zhaoxia Cai, and Ying Ma
- Subjects
16S rRNA sequencing ,Diversity ,Dysbiosis ,Genital tract ,Gut microbiome ,Gynecological disease ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis. Methods We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean difference (SMD) was conducted using the inverse-variance method for alpha diversity indices. Results Of 3327 unique articles, 87 eligible studies were included. Significant decreases were found in gut microbiome of patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 to -0.09; Shannon index SMD=-0.23; 95%CI, -0.40 to -0.06), whereas significant increases were observed in vaginal microbiome (Chao1 SMD = 1.15; 95%CI, 0.74 to 1.56; Shannon index SMD = 0.51; 95%CI, 0.16 to 0.86). Most studies of different diagnostic categories showed no significant differences in beta diversity. Disease specificity was observed, but almost all the changes were only replicated in three studies, except for the increased Aerococcus in bacterial vaginosis (BV). Patients with major gynecological diseases shared the enrichment of Prevotella and depletion of Lactobacillus, and an overlap in microbes was implied between BV, cervical intraepithelial neoplasia, and cervical cancer. Conclusions These findings demonstrated an association between alterations in gut and genital microbiota and gynecological diseases. The most observed results were shared alterations across diseases rather than disease-specific alterations. Therefore, further investigation is required to identify specific biomarkers for diagnosis and treatment in the future.
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- 2024
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- View/download PDF
3. Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis.
- Author
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Zhou, Ziwei, Feng, Yifei, Xie, Lishan, Ma, Song, Cai, Zhaoxia, and Ma, Ying
- Subjects
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FEMALE reproductive organ diseases , *CERVICAL intraepithelial neoplasia , *GUT microbiome , *BACTERIAL vaginitis , *GENITALIA , *NUCLEOTIDE sequencing , *CERVICAL cancer - Abstract
Background: Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis. Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean difference (SMD) was conducted using the inverse-variance method for alpha diversity indices. Results: Of 3327 unique articles, 87 eligible studies were included. Significant decreases were found in gut microbiome of patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 to -0.09; Shannon index SMD=-0.23; 95%CI, -0.40 to -0.06), whereas significant increases were observed in vaginal microbiome (Chao1 SMD = 1.15; 95%CI, 0.74 to 1.56; Shannon index SMD = 0.51; 95%CI, 0.16 to 0.86). Most studies of different diagnostic categories showed no significant differences in beta diversity. Disease specificity was observed, but almost all the changes were only replicated in three studies, except for the increased Aerococcus in bacterial vaginosis (BV). Patients with major gynecological diseases shared the enrichment of Prevotella and depletion of Lactobacillus, and an overlap in microbes was implied between BV, cervical intraepithelial neoplasia, and cervical cancer. Conclusions: These findings demonstrated an association between alterations in gut and genital microbiota and gynecological diseases. The most observed results were shared alterations across diseases rather than disease-specific alterations. Therefore, further investigation is required to identify specific biomarkers for diagnosis and treatment in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery
- Published
- 2023
5. Online Education and Counseling Regarding Gynecological Examination
- Author
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Belma Toptas Acar, Principal Investigator
- Published
- 2023
6. Epidemiology of endometriosis in women of Arab ancestry
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Mousa, Mira, Zondervan, Krina, Rahmioglu, Nilufer, and Becker, Christian
- Subjects
Genetic epidemiology ,Epidemiology ,Women's and Reproductive Health ,Endometriosis ,Gynecological Disease - Abstract
Introduction: Investigating the epidemiology of endometriosis in women of Arab ancestry, in the context of regionally important environmental and genetic effects, will provide us with a better understanding on the endometriosis phenome across different populations. Under the following initiative, the Middle Eastern Women Research Association: the MAR'A project, the study aimed to investigate for the first time in women of Arab ancestry: (1) Associations of symptomatology, risk factors, phenotypic profile, and comorbidities with endometriosis (2) Assess the impact of endometriosis on health-related quality of life (HRQoL), work productivity, activity impairment, physical activity, and diagnostic delay (3) Conduct a candidate gene association study (CGAS) on variants in wingless-type MMTV integration site family member 4 (WNT4) and the Vezatin (VEZT) in women with endometriosis. Method: The MAR'A Project is a case-control study with multiple hospital and population-based sites across the United Arab Emirates, between August 2018 and August 2019. In total, 2,610 (518 endometriosis cases; 2092 controls) premenopausal women, aged 18-50 years, without a previous surgical diagnosis of endometriosis and self-reported ethnically Arab, were recruited. The study design of a case-control study compared incident endometriosis cases (n=518) with the following two comparison groups to evaluate potential risk factors: (1) ascertainment criteria (hospital controls (n=1251) vs. population controls (n=841)); and (2) symptomatic criteria (symptomatic controls (n=1331) vs. asymptomatic controls (n=761)). A subset of the samples (100 endometriosis cases and 100 hospital controls) was selected for the CGAS. Standardized, validated questionnaires, basic anthropometric measurements and saliva samples were collected from consenting participants. Results: (1) Women with endometriosis had a lower BMI and WHRadjBMI, reported a higher frequency of pain phenotypes (dysmenorrhea, chronic pelvic pain, dysuria, and dyschezia) with greater severity, earlier age of symptom onset, and higher pain catastrophizing score, in comparison to controls. Similar to the Western population studies, women with endometriosis had earlier age at menarche, shorter menstrual cycle, heavier menstrual flow, and longer duration of menstrual phase. Women with endometriosis had a higher frequency of miscarriages, ectopic pregnancy, preterm birth, and emergency caesarean section. (2) The average diagnostic delay was 11.61 years, with single women experiencing 15.81 years of diagnosis delay. HRQoL scores were significantly impaired in women with endometriosis, for both the Physical and Mental Composite Scores, affecting work productivity and activity impairment. (3) A significant association was observed for SNP rs12320196 (OR=1.60 (95% CI: 1.05, 2.45), p=0.027) intronic to the VEZT gene, and SNPs rs12037376 (OR=1.89 (95% CI: 1.06, 3.37), p=0.029) and rs3820282 (OR=1.90 (95% CI: 1.05, 3.46), p=0.033) intronic to the WNT4 gene. Conclusion: This study provided novel findings of the clinical presentation and risk factors of endometriosis among Arab women from a combined hospital and population-based sites. Along with the presence, duration and severity of the pain phenotypes, adverse reproductive outcomes, and comorbidities, Arab women experience among the highest diagnostic delay of endometriosis. Social exacerbation and cultural factors may influence management of endometriosis-associated pain, leading to psychological distress and significant impacts on HRQoL. Further research must be conducted among Arab women to improve early diagnosis and provide culturally sensitive clinical care.
- Published
- 2021
7. Diet in Prevention and Treatment of Endometriosis: Current State of Knowledge
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Oszajca, Katarzyna and Adamus, Adrianna
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- 2024
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8. Association between red blood cell folate and Trichomonas vaginalis infection among women
- Author
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Wan-Zhe Liao, Zhi-Yi Zhou, Jun-Hao Mao, Zi-Xun Wang, Yi-Ming Hu, Yong-Fu Lou, Qiao-Rui Zheng, and Xu-Guang Guo
- Subjects
Trichomonas vaginalis ,RBC folate ,NHANES ,Multivariate regression models ,Gynecological disease ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan. Methods We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women. Results In the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups. Conclusions The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found.
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- 2023
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9. Arterial Hypertension in Women: State of the Art and Knowledge Gaps.
- Author
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Chapman, Niamh, Ching, Siew M., Konradi, Aleksandra O., Nuyt, Anne Monique, Khan, Taskeen, Twumasi-Ankrah, Betty, Cho, Eun J., Schutte, Aletta E., Touyz, Rhian M., Steckelings, U. Muscha, and Brewster, Lizzy M.
- Abstract
Hypertension is the leading risk factor for cardiovascular disease and premature death among women globally. However, there is a fundamental lack of knowledge regarding the sex-specific pathophysiology of the condition. In addition, risk factors for hypertension and cardiovascular disease unique to women or female sex are insufficiently acknowledged in clinical guidelines. This review summarizes the existing evidence on women and female-specific risk factors and clinical management of hypertension, to identify critical knowledge gaps relevant to research, clinical practice, and women's heart health awareness. Female-specific risk factors relate not only to reproduction, such as the association of gynecological conditions, adverse pregnancy outcomes or menopause with hypertension, but also to the specific roles of women in society and science, such as gender differences in received medical care and the underrepresentation of women in both the science workforce and as participants in research, which contribute to the limited evidence-based, gender- or sex-specific recommendations. A key point is that the development of hypertension starts in young, premenopausal women, often in association with disorders of reproductive organs, and therefore needs to be managed early in life to prevent future cardiovascular disease. Considering the lower blood pressure levels at which cardiovascular disease occurs, thresholds for diagnosis and treatment of hypertension may need to be lower for women. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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10. Association between red blood cell folate and Trichomonas vaginalis infection among women.
- Author
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Liao, Wan-Zhe, Zhou, Zhi-Yi, Mao, Jun-Hao, Wang, Zi-Xun, Hu, Yi-Ming, Lou, Yong-Fu, Zheng, Qiao-Rui, and Guo, Xu-Guang
- Subjects
- *
TRICHOMONAS vaginalis , *TRICHOMONIASIS , *ERYTHROCYTES , *FOLIC acid , *HEALTH & Nutrition Examination Survey - Abstract
Background: Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid emphasis on whether RBC (Red Blood Cell) folate was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan. Methods: We set RBC folate as the exposure variable and Trichomonas vaginalis as the outcome variable. Other subsidiary variables were regarded as covariates that may work as potential effect modifiers. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negative and 62 positive in Trichomonas vaginalis infection) was integrated for the exploration of the association between RBC folate and Trichomonas vaginalis infection. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in women. Results: In the multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T. vaginalis (Trichomonas vaginalis) infection. In subgroup analyses stratified by BMI and age, this association was only found significant in high age and BMI groups. Conclusions: The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection, and latent effects of BMI and age on the association were also found. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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11. Optimal Haloperidol Dose for Postoperative Nausea and Vomiting Prevention in High-risk Patients
- Author
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Young Eun Moon, clinical associate professor
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- 2020
12. Effects of subcutaneous drain on wound dehiscence and infection in gynecological midline laparotomy: Secondary analysis of a Korean Gynecologic Oncology Group study (KGOG 4001).
- Author
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Choi, Chel Hun, Kim, Nam Kyeong, Kim, Kidong, Lee, Yong Jae, Lee, Keun Ho, Lee, Jong-Min, Lee, Kwang Beom, Suh, Dong Hoon, Kim, Sunghoon, Kim, Min Kyu, Seong, Seok Ju, and Lim, Myong Cheol
- Subjects
SURGICAL wound dehiscence ,FEMALE reproductive organ diseases ,WOUND infections ,GYNECOLOGIC oncology ,ONCOLOGIC surgery - Abstract
To identify the effects of subcutaneous drain insertion on wound dehiscence and infection in patients who underwent gynecological midline laparotomy. This analysis identified the secondary endpoints of the KGOG 4001 study, a prospective, multicenter, non-blind, randomized controlled trial. Patients scheduled to undergo midline laparotomy for gynecological diseases and, with body mass index<35 kg/m
2 , were randomized (1:1) to treatment (with subcutaneous drain) and control (without subcutaneous drain) groups from February 2021 to December 2021. We compared the incidence rate of wound dehiscence 4 weeks post-surgery and the cumulative incidence rate of wound dehiscence and infection up to 4 weeks post-surgery between the two groups. Of 174 patients randomized to the treatment (n = 84) and control (n = 90) groups, 12 were excluded owing to loss to follow-up; finally, 162 patients (treatment, n = 79; control, n = 83) were included in intention-to-treat analysis. The frequency of cancer surgery (79.7 % vs. 77.1 %, p = 0.683), mean surgery time (227.7 vs. 226.7 min, p = 0.960), and mean wound length (24.2 vs. 24.3 cm, p = 0.933) were comparable between two groups. No significant differences were observed in the incidence rate of wound dehiscence 4 weeks post-surgery (1.3 % vs. 2.4 %, p > 0.999), cumulative incidence rate of wound dehiscence (8.9 % vs. 6.0 %, p = 0.491), and cumulative incidence rate of wound infection (1.3 % vs. 0.0 %, p = 0.488) up to 4 weeks post-surgery between the two groups. Subcutaneous drain insertion is not associated with a significant improvement in the incidence of wound dehiscence and infection in patients who undergo gynecological midline laparotomy. ClinicalTrials.gov, NCT04643197. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Chinese herbal medicine hot compress based on midnight-noon ebb-flow theory in relief of postoperative gastrointestinal dysfunction in a patient undergoing abdominal gynecological surgery and related nursing management (基于子午流注理论的中药热奄包改善妇科腹部手术后胃肠功能紊乱1例的护理)
- Author
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SHEN Yueyue (申月月), ZHU Lei (朱磊), TANG Ling (唐玲), XU Jingjin (徐京巾), and LU Ying (卢英)
- Subjects
midnight-noon ebb-flow theory ,hot compress with chinese herbal medicine package ,gynecological disease ,abdominal operation ,gastrointestinal function ,traditional chinese medicine nursing ,子午流注 ,热奄包 ,妇科疾病 ,腹部手术 ,胃肠功能 ,中医护理 ,Nursing ,RT1-120 - Abstract
This paper summarized treatment and nursing experience of Chinese herbal medicine hot compress based on midnight-noon ebb-flow theory in relief of postoperative gastrointestinal dysfunction in a patient undergoing abdominal gynecological surgery and related nursing management. Nurses were educated about time selection of hot compress based on midnight-noon ebb-flow theory, operation procedure and precautions. Other targeted nursing interventions on diet and living habits were carried out to relieve the postoperative gastrointestinal dysfunction and improve the recovery. (本文总结了基于子午流注理论的中药热奄包热敷改善1例妇科开腹手术患者术后胃肠功能紊乱的护理经验, 包括确定中药热奄包热敷的时间点、热敷操作方法和注意事项, 以及饮食护理、生活护理等, 通过针对性干预, 进而有效改善患者的胃肠功能, 促进患者康复。)
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- 2021
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14. Endometriosis: A Disease with Few Direct Treatment Options.
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França, Patricia Ribeiro de Carvalho, Lontra, Anna Carolina Pereira, and Fernandes, Patricia Dias
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- *
ENDOMETRIOSIS , *PELVIS , *THERAPEUTICS - Abstract
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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15. Notch signaling in reproduction.
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Moldovan, Genna E., Miele, Lucio, and Fazleabas, Asgerally T.
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FEMALE reproductive organs , *NOTCH signaling pathway , *MALE reproductive organs , *GENITALIA , *RECURRENT miscarriage - Abstract
The Notch signaling pathway is conserved among mammalian species and controls proliferation, differentiation, and cell death in many organs throughout the body including the reproductive tract. Notch signaling plays critical roles in the development and function of both the male and female reproductive systems. Specifically, within the female reproductive tract, Notch signaling is hormone regulated and mediates key reproductive events important for ovarian and uterine function. In this review, we highlight the tissues that express Notch receptors, ligands, and downstream effectors and distinguish how these molecules regulate reproductive function in male and female mice, non-human primates, and humans. Finally, we describe some of the aberrations in Notch signaling in female reproductive pathologies and identify opportunities for future investigation. The Notch signaling pathway is an important mediator of cell fate controlling cell proliferation, differentiation, and cell death. Notch signaling contributes to the reproductive function of the male and female reproductive organs. Notch signaling is hormonally regulated. The Notch signaling pathway is implicated in gynecological pathologies such as polycystic ovary syndrome, adenomyosis, endometriosis, pre-eclampsia, recurrent pregnancy loss and infertility, and endometrial cancer. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Prevalence of Common Gynecological Conditions in the Middle East: Systematic Review and Meta-Analysis
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Mira Mousa, Moamar Al-Jefout, Habiba Alsafar, Shona Kirtley, Cecilia M. Lindgren, Stacey A. Missmer, Christian M. Becker, Krina T. Zondervan, and Nilufer Rahmioglu
- Subjects
gynecological disease ,epidemiology ,global health ,Middle East ,polycystic ovary syndrome ,endometriosis ,Reproduction ,QH471-489 ,Medicine (General) ,R5-920 - Abstract
Introduction: High prevalence of gynecological conditions in women of Middle Eastern origin is reported, likely due to regional risk factors and mediators. The objective of this systematic review and meta-analysis is to investigate the prevalence of polycystic ovary syndrome (PCOS), endometriosis, uterine fibroids, and adenomyosis in women of Middle Eastern origin.Methods: MEDLINE, EMBASE, PsycINFO, Global Health, and Google Scholar databases were searched from database inception until 14 February 2021 to identify relevant studies. Peer-reviewed research articles that reported the prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern population were written in English or Arabic. The primary outcome was the estimated pooled prevalence of PCOS, endometriosis, uterine fibroids, and adenomyosis in the Middle Eastern populations. The secondary outcome was to assess the evidence in the data for the presence of heterogeneity, by conducting subtype-pooled analysis of prevalence estimates of the conditions. Total weighted prevalence was calculated via Freeman–Tukey arcsine transformation and heterogeneity through the I2 statistic. Quality control was performed using GRADE criteria.Results: A total of 47 studies, 26 on PCOS, 12 on endometriosis, eight on uterine fibroids, and seven on adenomyosis, were included. The pooled prevalence of PCOS diagnosed according to the NIH criteria was 8.9% (95% CI: 6.5–11.7; prevalence range: 4.0–27.6%), with a higher prevalence from the Gulf Arab states (18.8%, 95% CI: 9.5–30.3; range: 12.1–27.6%). According to the Rotterdam criteria, the pooled prevalence of PCOS was 11.9% (95% CI: 7.1–17.7; range: 3.4–19.9%) with studies limited to the Persian and Levant regions. Endometriosis was diagnosed in 12.9% (95% CI: 4.2–25.4; range: 4.2–21.0%) of women undergoing laparoscopy, for any indication. Uterine fibroid and adenomyosis prevalence of women was 30.6% (95% CI: 24.9–36.7; range: 18.5–42.6%) and 30.8% (95% CI: 27.1–34.6, range: 25.6–37.7%), respectively. Heterogeneity was present between studies due to statistical and methodological inconsistencies between studies, and quality of evidence was low due to sample size and unrepresentative participant selection.Conclusion: This is the first review that has reported the prevalence of gynecological diseases in the Middle Eastern population, suggesting that gynecological morbidity is a public health concern. Due to the health disparities in women, further research is required to understand the relative roles of environmental and genetic factors in the region to serve as a benchmark for evaluation and comparative purposes with other populations.
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- 2021
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17. Endometriosis: A Disease with Few Direct Treatment Options
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Patricia Ribeiro de Carvalho França, Anna Carolina Pereira Lontra, and Patricia Dias Fernandes
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endometriosis ,gynecological disease ,inflammation ,drug therapy ,Organic chemistry ,QD241-441 - Abstract
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs. Currently, available medications are only effective in treating endometriosis-related pain; however, it is not a targeted treatment. The objective of this work is to review the characteristics of the disease, the diagnostic means and treatments available, as well as to discuss new therapeutic options.
- Published
- 2022
- Full Text
- View/download PDF
18. Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats.
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Takiyama, Mikina, Matsumoto, Takashi, Sanechika, Sho, and Watanabe, Junko
- Abstract
Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecological diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of the pharmacological actions of shimotsuto is traditionally considered to be exerted by an improvement effect of the blood and the circulatory system. Multiple ingredients (e.g., catalpol and paeoniflorin) contained in shimotsuto have been reported to have pharmacological activities on the blood and circulatory system, and thus been considered to contribute to the pharmacological actions of shimotsuto. However, it remains unclear whether the ingredients can be absorbed into the body following oral administration of shimotsuto. The aim in the present study was to specify shimotsuto ingredient absorbed into the systemic circulation in rats. Seven candidate active ingredients (catalpol, paeoniflorin, albiflorin, ligustilide, senkyunolide A, butylphthalide, and ferulic acid) in plasma after oral administration of shimotsuto were quantified by targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis. This study also performed nontargeted LC–MS/MS analysis of plasma following administration of constituent crude drugs of shimotsuto to find extensively blood-absorbed ingredients of shimotsuto. Among detected peaks in the nontargeted analysis, two peaks could be identified as bergapten and 8-debenzoylpaeoniflorin, subsequently their concentrations in shimotsuto-treated rat plasma were quantified. These pharmacokinetic studies indicated that catalpol showed the highest plasma concentration following administration of shimotsuto, followed by 8-debenzoylpaeoniflorin. This study suggests that all nine ingredients are absorbed into the blood following oral administration of shimotsuto and possibly contribute to its pharmacological action. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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19. Development of the Blood Stasis Questionnaire for Gynecological Diseases: An Analytical Cross-Sectional Study.
- Author
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Kang BK, Jang S, Ko MM, and Jung J
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- Humans, Female, Cross-Sectional Studies, Middle Aged, Adult, Surveys and Questionnaires, Aged, Reproducibility of Results, Sensitivity and Specificity, Genital Diseases, Female diagnosis
- Abstract
Objectives: Blood stasis is the slowing or stagnation of blood and can cause metabolic, musculoskeletal, and gynecological diseases. This study developed the Blood Stasis Questionnaire for gynecological disease (BSQ-GD) by extracting clinical indicators related to gynecological diseases using the Blood Stasis Questionnaires I and II (BSQ-I and II, respectively) and analyzed the clinical data of a cross-sectional study., Patients and Methods: In total, 103 women aged between 25 and 65 years who met gynecological disease criteria were enrolled in this study. Blood stasis scores (BSS) were evaluated using the BSQ-II and categorized into BSS and non-BSS groups. To assess the reliability of BSQ-GD, the internal consistency coefficient was employed using Cronbach's α. Furthermore, correlation analyses were conducted for the clinical symptoms related to gynecological diseases, and the discriminant validity was confirmed by comparing the two groups. The prediction accuracy was determined using logistic regression and the cut-off value of the BSQ-GD was established via the sensitivity and specificity calculations., Results: The BSQ-GD showed satisfactory internal consistency (Cronbach's α coefficient = 0.71) and validity, with significant differences in mean scores between blood stasis (22.30 ± 3.34) and non-blood stasis (14.93 ± 3.49) groups. The cut-off value of the BSQ-GD score was 19 points when the Youden index (73.45) and the concordance probability (0.75) were at their maximum. The area under the receiver operating characteristic curve was approximately 96%, and the sensitivity and specificity of the diagnostic accuracy according to the cut-off value are 80.95% and 92.50%, respectively., Conclusion: The BSQ-GD can be an appropriate instrument to estimate blood stasis in patients with gynecological diseases; its diagnostic sensitivity according to the cut-off value is high., (© 2024 S. Karger AG, Basel.)
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- 2024
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20. The Molecular Basis of Adenomyosis Development
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Woo Sub Yang, Jeong Mook Lim, and Ji Yeon Ahn
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adenomyosis ,pathogenesis ,molecular mechanisms ,gynecological disease ,adenomyoma ,Biotechnology ,TP248.13-248.65 ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Adenomyosis is a benign gynecological disease frequently affecting women of reproductive age. It has a negative impact on the quality of life, causing bleeding disorders, dysmenorrhea, chronic pelvic pain, and infertility. However, the molecular mechanisms involved in adenomyosis development remain unclear. This paper summarizes the reports found in the MEDLINE database on the molecular mechanisms involved in the development and progression of uterine adenomyosis. The literature search included the following terms: “adenomyosis,” “adenomyoma,” “pathogenesis,” “molecular mechanisms,” and “gynecological disorders.” Only peer-reviewed, English-language journal articles were included. This review focuses on the molecular genetics, epigenetic modifications, and pivotal signaling pathways associated with adenomyosis development and progression, which will provide insights into and a better understanding of its underlying pathophysiology.
- Published
- 2018
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21. Chinese expert consensus on clinical application of female contraceptive methods
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Li-Nan Cheng, Wen Di, Yan Ding, Guang-Sheng Fan, Xiang-Ying Gu, Min Hao, Jing He, Li-Na Hu, Ke-Qin Hua, Wei Huang, Li Jin, Bei-Hua Kong, Jing-He Lang, Jin-Hua Leng, Jian Li, Cai-Xia Liu, Guan-Yuan Liu, Lei Song, Xiao-Ye Wang, Shang-Chun Wu, Min Xue, Hui-Xia Yang, Qing Yang, Shu-Zhong Yao, Zhen-Yu Zhang, Ying-Fang Zhou, and Lan Zhu
- Subjects
Contraceptive Methods ,Gynecological Disease ,Postabortion Contraception ,Postpartum Family Planning ,Unintended Pregnancy ,Immunologic diseases. Allergy ,RC581-607 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Unintended pregnancy is a global issue, with approximately 85,000,000 women around the world having unintended pregnancy annually. The contents of clinical application of women's contraceptive methods are very wide, involving multiple areas. This consensus deeply discusses the specific contraceptive needs at different statuses, combined with gynecological diseases, postabortion contraception, and postpartum family planning, ensuring the correct use of contraceptive methods under the corresponding status. The top priority of the consensus is the specific contraception consensus section for women combined with gynecological diseases because medical treatment effect as well as side effects should be weighed carefully. The consensus is to make high-efficiency and individual contraceptive strategy for different groups based on multidisciplinary (gynecology, obstetrics, and family planning) and multidimensional aspects, which can provide uniform guidance for medical and health organizations under the condition as relevant global guidance or consensus is still lacking.
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- 2018
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22. Ancient and Modern Literature Research on Danshen Prescriptions
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Zhu, Guoguang, Shi, Xinde, Zhao, Jingsheng, and Yan, Xijun, editor
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- 2015
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23. Sevoflurane, Propofol, Postoperative Pain
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Arvi Yli-Hankala, Professor
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- 2013
24. Clinical application of serum anti‐Müllerian hormone as an ovarian reserve marker: A review of recent studies.
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Iwase, Akira, Osuka, Satoko, Goto, Maki, Murase, Tomohiko, Nakamura, Tomoko, Takikawa, Sachiko, and Kikkawa, Fumitaka
- Subjects
- *
INFERTILITY treatment , *OVARIAN diseases , *OVARIAN surgery , *AGING , *BIOMARKERS , *SEX hormones , *HUMAN reproductive technology , *MENOPAUSE , *POLYCYSTIC ovary syndrome , *STATISTICAL models , *OVARIAN reserve , *DIAGNOSIS - Abstract
Abstract: It has been more than 15 years since the measurement of serum anti‐Müllerian hormone (AMH) first allowed the quantitative assessment of ovarian reserve. Meanwhile, the clinical implication of serum AMH has been expanding. The measurement of serum AMH has been applied in various clinical fields, including assisted reproduction, menopause, reproductive disorders and assessment of ovarian damage/toxicity. Well‐known findings about the usefulness of serum AMH revealed by numerous studies executed in the early era include decline with aging, a good correlation with oocyte yield in assisted reproduction, upregulation in polycystic ovarian syndrome and a decrease on ovarian surgery and toxic treatment. More intensive research, including a meta‐analysis, cutting‐edge clinical trial and advances in AMH assays, has yielded newer findings and firmer clinical interpretations in serum AMH in the past few years. Variations in the AMH decline trajectory in the general population do not support the accurate prediction of menopause. The ability to predict pregnancy in infertility treatment and natural conception is poor, while a nomogram integrating serum AMH as a stimulation protocol is useful for avoiding poor and/or hyper‐responses. On the other hand, improvements in measuring very low concentrations of serum AMH may be capable of distinguishing women with poor ovarian function. Age‐independent standardization of AMH values may be helpful for comparing ovarian reserves among women at different ages. [ABSTRACT FROM AUTHOR]
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- 2018
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25. Novel herbs and drugs for endometriosis management: A review on current and futuristic therapies
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Mohan Kumar A, Hemamalini Baskaran, Priyanka J, Sriram Gm, S. Komal, Gejalakshmi S, Harikrishnan N, and Kayalvizhi S
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Infertility ,medicine.diagnostic_test ,Gynecological disease ,medicine.drug_class ,business.industry ,Endometriosis ,Disease ,medicine.disease ,Bioinformatics ,Quality of life ,Estrogen ,medicine ,Endometriosis surgery ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Laparoscopy - Abstract
A disorder with estrogen dependency comprising of inflammatory lesions outside the uterus, causing pain and inflammation in pelvis and affecting women of reproductive age with infertility and post reproductive age is endometriosis. Endometriosis is viewed as public health issue with a major impact on quality of life of women. Medically advanced computational and chemical treatments are available to treat the progression of the disease by diagnostic imaging, clinical examinations, imaging and laparoscopy often leading to immediate surgery. A warrantable rethinking on the diagnosis and management of endometriosis is to be assessed and medical treatments should be considered as first-line option for therapeutic relief for endometriosis by suppressing the systemic estrogen levels providing desirable efficacy and safety, prior to performing endometriosis surgery. The aim of this review is to describe natural products, hormonal and non-hormonal compounds that suppress the progression of endometriosis. Various herbal, conventional and traditional therapies are investigated to treat gynecological disease, endometriosis. The information in this paper include various studies assessing the use of novel treatments in addition to the herbal and hormonal products in the endometriosis therapy. Most of the studies involved were in scrutinizing the pharmacological activity profiles of various sources of drugs in endometriosis treatment, hormonal drugs involved suppression and regulation of various hormones along with various factors like anti-inflammatory, anti-oxidant, anti-proliferative and apoptotic, anti-angiogenic, anti-invasive, immunomodulatory, and estrogen modulating activity. However, novel drugs and medicinal plants are also reviewed here to draw attention to the molecules of drugs that target at multiple points for rational therapeutic treatment of endometriosis.
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- 2021
26. Epidemiology of endometriosis in women of Arab ancestry
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Mousa, M, Zondervan, K, Rahmioglu, N, and Becker, C
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Gynecological Disease ,Epidemiology ,Women's and Reproductive Health ,Endometriosis ,Genetic epidemiology - Abstract
Introduction Investigating the epidemiology of endometriosis in women of Arab ancestry, in the context of regionally important environmental and genetic effects, will provide us with a better understanding on the endometriosis phenome across different populations. Under the following initiative, the Middle Eastern Women Research Association: the MAR’A project, the study aimed to investigate for the first time in women of Arab ancestry: (1) Associations of symptomatology, risk factors, phenotypic profile, and comorbidities with endometriosis (2) Assess the impact of endometriosis on health-related quality of life (HRQoL), work productivity, activity impairment, physical activity, and diagnostic delay (3) Conduct a candidate gene association study (CGAS) on variants in wingless-type MMTV integration site family member 4 (WNT4) and the Vezatin (VEZT) in women with endometriosis. Method The MAR’A Project is a case-control study with multiple hospital and population-based sites across the United Arab Emirates, between August 2018 and August 2019. In total, 2,610 (518 endometriosis cases; 2092 controls) premenopausal women, aged 18-50 years, without a previous surgical diagnosis of endometriosis and self-reported ethnically Arab, were recruited. The study design of a case-control study compared incident endometriosis cases (n=518) with the following two comparison groups to evaluate potential risk factors: (1) ascertainment criteria (hospital controls (n=1251) vs. population controls (n=841)); and (2) symptomatic criteria (symptomatic controls (n=1331) vs. asymptomatic controls (n=761)). A subset of the samples (100 endometriosis cases and 100 hospital controls) was selected for the CGAS. Standardized, validated questionnaires, basic anthropometric measurements and saliva samples were collected from consenting participants. Results (1) Women with endometriosis had a lower BMI and WHRadjBMI, reported a higher frequency of pain phenotypes (dysmenorrhea, chronic pelvic pain, dysuria, and dyschezia) with greater severity, earlier age of symptom onset, and higher pain catastrophizing score, in comparison to controls. Similar to the Western population studies, women with endometriosis had earlier age at menarche, shorter menstrual cycle, heavier menstrual flow, and longer duration of menstrual phase. Women with endometriosis had a higher frequency of miscarriages, ectopic pregnancy, preterm birth, and emergency caesarean section. (2) The average diagnostic delay was 11.61 years, with single women experiencing 15.81 years of diagnosis delay. HRQoL scores were significantly impaired in women with endometriosis, for both the Physical and Mental Composite Scores, affecting work productivity and activity impairment. (3) A significant association was observed for SNP rs12320196 (OR=1.60 (95% CI: 1.05, 2.45), p=0.027) intronic to the VEZT gene, and SNPs rs12037376 (OR=1.89 (95% CI: 1.06, 3.37), p=0.029) and rs3820282 (OR=1.90 (95% CI: 1.05, 3.46), p=0.033) intronic to the WNT4 gene. Conclusion This study provided novel findings of the clinical presentation and risk factors of endometriosis among Arab women from a combined hospital and population-based sites. Along with the presence, duration and severity of the pain phenotypes, adverse reproductive outcomes, and comorbidities, Arab women experience among the highest diagnostic delay of endometriosis. Social exacerbation and cultural factors may influence management of endometriosis-associated pain, leading to psychological distress and significant impacts on HRQoL. Further research must be conducted among Arab women to improve early diagnosis and provide culturally sensitive clinical care.
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- 2022
27. Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats
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Junko Watanabe, Mikina Takiyama, Takashi Matsumoto, and Sho Sanechika
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Male ,Kampo ,Pharmacology ,Bergapten ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Pharmacokinetics ,Tandem Mass Spectrometry ,Oral administration ,Animals ,Medicine ,Shimotsuto ,Gynecological disease ,Active ingredients ,Chromatography, High Pressure Liquid ,030304 developmental biology ,Active ingredient ,Original Paper ,0303 health sciences ,business.industry ,Paeoniflorin ,Catalpol ,Rats ,Butylphthalide ,chemistry ,Blood and circulatory system ,Molecular Medicine ,Female ,Medicine, Kampo ,business ,Genital Diseases, Female ,030217 neurology & neurosurgery - Abstract
Abstract Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecological diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of the pharmacological actions of shimotsuto is traditionally considered to be exerted by an improvement effect of the blood and the circulatory system. Multiple ingredients (e.g., catalpol and paeoniflorin) contained in shimotsuto have been reported to have pharmacological activities on the blood and circulatory system, and thus been considered to contribute to the pharmacological actions of shimotsuto. However, it remains unclear whether the ingredients can be absorbed into the body following oral administration of shimotsuto. The aim in the present study was to specify shimotsuto ingredient absorbed into the systemic circulation in rats. Seven candidate active ingredients (catalpol, paeoniflorin, albiflorin, ligustilide, senkyunolide A, butylphthalide, and ferulic acid) in plasma after oral administration of shimotsuto were quantified by targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis. This study also performed nontargeted LC–MS/MS analysis of plasma following administration of constituent crude drugs of shimotsuto to find extensively blood-absorbed ingredients of shimotsuto. Among detected peaks in the nontargeted analysis, two peaks could be identified as bergapten and 8-debenzoylpaeoniflorin, subsequently their concentrations in shimotsuto-treated rat plasma were quantified. These pharmacokinetic studies indicated that catalpol showed the highest plasma concentration following administration of shimotsuto, followed by 8-debenzoylpaeoniflorin. This study suggests that all nine ingredients are absorbed into the blood following oral administration of shimotsuto and possibly contribute to its pharmacological action. Graphic abstract
- Published
- 2021
28. Clinical profile of patients with benign gynecological disease subjected for hysterectomy
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Harini R and Sushma S
- Subjects
medicine.medical_specialty ,Hysterectomy ,Gynecological disease ,business.industry ,Obstetrics ,medicine.medical_treatment ,Medicine ,business - Published
- 2021
29. Peri-operative morbidity between total laparoscopic hysterectomy and abdominal hysterectomy for benign gynecological disease: A prospective comparative study
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Sushma S and Harini R
- Subjects
medicine.medical_specialty ,Gynecological disease ,business.industry ,General surgery ,medicine ,Total laparoscopic hysterectomy ,Perioperative ,business ,Abdominal hysterectomy - Published
- 2021
30. Serum anti-Mullerian hormone, prolactin and estradiol concentrations in infertile women with endometriosis
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Roksana Tukhtarian, Natalia Pedachenko, Lina Alabbas, Taras Shemelko, and Panagiotis Anagnostis
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Adult ,Anti-Mullerian Hormone ,Infertility ,Gynecological disease ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,Endometriosis ,Physiology ,030209 endocrinology & metabolism ,Fertility ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Humans ,Medicine ,Ovarian reserve ,media_common ,030219 obstetrics & reproductive medicine ,Estradiol ,biology ,business.industry ,Obstetrics and Gynecology ,Anti-Müllerian hormone ,medicine.disease ,Prolactin ,Cross-Sectional Studies ,biology.protein ,Female ,business ,Infertility, Female ,Hormone - Abstract
Endometriosis is a benign gynecological disease, which significantly impairs fertility. However, the contribution of specific hormonal parameters to the proper diagnosis of endometriosis in infertility states has not been adequately determined. The aim of this study was to compare ant-Mullerian hormone (AMH), prolactin and estradiol concentrations between infertile women with and without endometriosis, as well as to estimate the effect of endometrioid heterotopia on ovarian reserve.In this cross-sectional study, mean baseline serum AMH, prolactin and estradiol levels were assessed in infertile women with and without endometriosis. Descriptive statistics are presented in the form of arithmetic mean ± standard deviation (SD). The comparison of indicators was performed by using parametric (Seventy-two infertile women with endometriosis (group A; mean age: 32 ± 4.3 years) and 77 infertile women without endometriosis (group B; mean age: 32.4 ± 3.7 years) were studied. Mean baseline prolactin concentrations were higher in group A (16.9 ± 5.7 ng/mL) compared with group B (15 ± 4.3 ng/mL;Infertile women with endometriosis demonstrated higher prolactin and lower AMH concentrations, compared with infertile women without endometriosis. The highest prolactin and the lowest AMH concentrations were observed in patients with ovarian endometriomas.
- Published
- 2020
31. The potentialities of oxytocin receptor inhibitors for endometriosis therapy
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Vladislav V. Khobets, Natalia N. Tkachenko, Tatyana G. Tral, and Maria I. Yarmolinskaya
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Adult ,Adolescent ,Gynecological disease ,Endocrinology, Diabetes and Metabolism ,Drug Evaluation, Preclinical ,Endometriosis ,030209 endocrinology & metabolism ,Oxytocin ,Pelvic Pain ,Peritoneal Diseases ,Bioinformatics ,Pathogenesis ,Young Adult ,03 medical and health sciences ,Vasotocin ,0302 clinical medicine ,Endocrinology ,medicine ,Animals ,Humans ,Sex organ ,Molecular Targeted Therapy ,Rats, Wistar ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Syndrome ,Middle Aged ,medicine.disease ,Oxytocin receptor ,Rats ,Disease Models, Animal ,Receptors, Oxytocin ,Case-Control Studies ,Female ,business ,medicine.drug - Abstract
Genital endometriosis (GE) is a widespread gynecological disease which requires its further pathogenesis investigation and search for new effective treatments. The known data of oxytocin receptor presence in endometrioid heterotopy smooth muscle cells give some grounds to assume oxytocin participation in the pathogenesis of endometriosis. The present study objective was to evaluate oxytocin level in peripheral blood (PB) in patients with endometriosis associated pain syndrome and to estimate the efficacy of oxytocin receptor inhibitors (IOXTR) administration based on animal endometriosis model.The basic group comprised 61 patients with endometriosis associated pain syndrome, while 21 patients formed the control group. VAS, MPQ, and BBS objective tests were applied for pain syndrome evaluation. Oxytocin level in PB was measured by immunoenzyme method. After confirmation of endometriosis experimental model formation in rats and further randomization, a daily IOXTR intra-abdominal injection was performed in a dose of 0.35 mg/kg/24 h in the basic group (Oxytocin level in PB was authentically higher in patients with GE compared to the control: 51.45 (35.54-62.76) pg/mL and 27.64 (23.23-34.12) pg/mL, respectively (The obtained results confirm the oxytocin role in the pathogenesis of endometrioid associated pain syndrome. The high efficacy of IOXTR administration based on animal model of surgically induced endometriosis allows viewing this method as a perspective therapy.
- Published
- 2020
32. Surgical outcome for robotic-assisted single-site hysterectomy (RSSH) in female-to male reassignment compared to its use in benign gynecological disease: a single center experience
- Author
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Stefano Bogliolo, Barbara Gardella, Mattia Dominoni, and Arsenio Spinillo
- Subjects
medicine.medical_specialty ,Hysterectomy ,Gynecological disease ,business.industry ,Endometrial cancer ,medicine.medical_treatment ,030232 urology & nephrology ,Health Informatics ,medicine.disease ,Single Center ,Comorbidity ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Single site ,030220 oncology & carcinogenesis ,medicine ,Robotic surgery ,business ,Body mass index - Abstract
This study was oriented to assess surgical outcomes, feasibility, and safety of Robotic-assisted Single-Site Hysterectomy and bilateral salpingo-oophorectomy (RSSH/BSO) performed for sexual reassignment compared to indications for the benign gynecologic disease. The present trial is a retrospective analysis of a prospectively collected database. After the exclusion of 3 patients with endometrial cancer on histological specimens, 112 subjects were considered for final analysis: 60 transgender men (TM) and 52 cisgender women (CW). There is a statistical difference in surgical time (total operative time p = 0.0152, docking p = 0.0011, console time p = 0.0001, and anesthesia time p = 0.0061) between TM and CW. Other than in TM, a significant difference in uterine volume (p = 0.0001), Body Mass Index (p = 0.0169), and previous comorbidity (p = 0.0001) was reported. There are no differences in conversion rate, the decrease in hemoglobin and blood loss, hospital stay, intra- and postoperative complications between the two groups. RSSH for sex reassignment appears to be a safe, viable, and cost-effective option with a significant decrease in surgical time compared to other indications for benign disease. In addition, the benefit of this scar-less surgical procedure appears to be more evident in TM’s due to the absence of traditional surgical stigmata.
- Published
- 2020
33. Chronic Pelvic Pain Patients with Gynecological Diseases Treated by Korean Medicine Treatment: Three Case Reports
- Author
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Jeong-Eun Yoo, Hae-Won Kim, Hee-Jae Yoon, and Seon-Eun Baek
- Subjects
medicine.medical_specialty ,Gynecological disease ,business.industry ,Internal medicine ,Pelvic pain ,Medicine ,medicine.symptom ,business - Published
- 2020
34. Modern methods for radiological diagnosis of endometriosis
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Alina O. Ivanova, Elena I. Rusina, and Maria I. Yarmolinskaya
- Subjects
medicine.medical_specialty ,Gynecological disease ,business.industry ,Endometriosis ,Obstetrics and Gynecology ,medicine.disease ,Deep infiltrating endometriosis ,medicine.anatomical_structure ,Radiological weapon ,medicine ,Treatment strategy ,Adenomyosis ,Radiology ,business ,Pelvis - Abstract
Endometriosis is a widespread gynecological disease, which affects reproductive-aged women. An accurate diagnosis is critical to develop a more comprehensive treatment strategy for endometriosis than is currently available. This article provides an overview of current data on the value of radiation techniques for the diagnosis of external genital and extragenital endometriosis, deep infiltrating endometriosis, and adenomyosis. The necessity of using a systematic approach to examine the pelvis in women with suspected endometriosis is shown, modern terms and methods of measurement being given to describe ultrasound picture of endometriosis.
- Published
- 2020
35. Novel MYH8 mutations in 152 Han Chinese samples with ovarian endometriosis
- Author
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Lei Wan, Xin Zeng, Ou-Ping Huang, Jun Lou, Ziyu Zhang, Yong Luo, Fa-Ying Liu, Yang Zou, and Jun Tan
- Subjects
Adult ,China ,medicine.medical_specialty ,Han chinese ,Gynecological disease ,Endocrinology, Diabetes and Metabolism ,Endometriosis ,Mutation, Missense ,030209 endocrinology & metabolism ,Reproductive age ,Polymorphism, Single Nucleotide ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Asian People ,medicine ,Humans ,Genetic Predisposition to Disease ,Ovarian Diseases ,Gynecology ,030219 obstetrics & reproductive medicine ,Myosin Heavy Chains ,business.industry ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Chin ,medicine.anatomical_structure ,Amino Acid Substitution ,Case-Control Studies ,Ovarian Endometriosis ,Female ,business - Abstract
Endometriosis is a common gynecological disease affecting up to 10% of women at reproductive age. Prior combined studies implied that MYH8 mutations might exist in endometriosis. Here, 152 Han Chinese samples with ovarian endometriosis were analyzed for the presence of MYH8 mutations. Two heterozygous missense mutations in the MYH8 gene, c.1441A C (p.I481L) and c.4057G A (p.E1353K), were identified in our samples. These mutations were neither found in public databases nor detected in our 485 Han Chinese control women without endometriosis. The p.I481L-mutated sample belonged to 34-year-old, who had slightly elevated serum CA 125 (42.09 U/mL); while the sample with p.E1353K mutation belonged to 25 years old, who had a markedly increased serum CA125 (89.86 U/mL). The evolutionary conservation analysis results suggested that these MYH8 mutations caused highly conserved amino acid substitutions among vertebrate species. Both the mutations were predicted to be 'disease causing' by MutationTaster and SIFT programs. In addition, no association was observed between MYH8 mutations and the available clinical data. In summary, the present study identified two novel potential pathogenic mutations in the MYH8 gene in samples with ovarian endometriosis for the first time, implying that MYH8 mutations might play a positive role in the pathogenesis of endometriosis.
- Published
- 2020
36. Where are the women?
- Author
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Meredith Wadman
- Subjects
medicine.medical_specialty ,Multidisciplinary ,Gynecological disease ,Sexism ,education ,National Institute of Child Health and Human Development (U.S.) ,United States ,Child health ,Health centre ,Human development (humanity) ,Age discrimination ,Adult women ,Career Mobility ,Laboratory Personnel ,Sex discrimination ,Family medicine ,medicine ,Women ,Psychology ,Equal employment opportunity - Abstract
Women at the National Institute of Child Health and Human Development (NICHD) are charging the institute9s outgoing scientific director with 10 years of sex discrimination. They say geneticist Constantine Stratakis oversaw a disproportionate decrease in the number of women leading experiment-running labs at the institute, and that he dismantled research on gynecological disease affecting adult women at the institute9s Bethesda, Maryland, campus. Between 2013 and 2019, at least eight female professionals at NICHD filed equal employment opportunity complaints charging Stratakis with sex discrimination, age discrimination, or both. Stratakis denies all the claims, saying he elevated institute women into leadership positions and actively recruited women including three new gynecologists focused on disease in children and teens. In June, he is set to take a new job as executive director of the Research Institute of the McGill University Health Centre.
- Published
- 2020
37. Ultrasound findings in infertile women with endometriosis: evidence of concomitant uterine disorders
- Author
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Silvia Vannuccini, Maria Elisabetta Coccia, Giulia Fantappiè, Giulia Orlandi, Francesca Rizzello, Tommaso Capezzuoli, and Felice Petraglia
- Subjects
Adult ,Infertility ,medicine.medical_specialty ,Gynecological disease ,Uterine fibroids ,Endocrinology, Diabetes and Metabolism ,Endometriosis ,Comorbidity ,Peritoneal Diseases ,Cohort Studies ,Endocrinology ,medicine ,Humans ,Adenomyosis ,Retrospective Studies ,Ultrasonography ,Uterine Diseases ,Gynecology ,Leiomyoma ,business.industry ,Uterus ,Ultrasound ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Uterine Disorder ,Concomitant ,Uterine Neoplasms ,Female ,business ,Infertility, Female - Abstract
Endometriosis is a gynecological disease characterized by pain and infertility. The diagnosis is very often made during the infertility work-up, together with other reproductive diseases and uterine disorders. A retrospective cohort study was conducted on infertile women with clinical or ultrasound suspect of endometriosis, undergoing an ultrasound (US) evaluation by a team of expert sonographers (
- Published
- 2020
38. Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment
- Author
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Tong Zhang, Wei Xiao, Biao Chen, De-Hui Du, Du Li, and Yue Ding
- Subjects
0301 basic medicine ,Pharmacology ,Gynecological disease ,medicine.drug_class ,Mechanism (biology) ,business.industry ,Angiogenesis ,Pharmaceutical Science ,Computational biology ,medicine.disease ,Anti-inflammatory ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Network pharmacology ,Drug Discovery ,medicine ,Adenomyosis ,KEGG ,business ,Target database - Abstract
Background Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and further studies are needed to reveal the role of SZC. Methods A systematic network pharmacology analysis was conducted by integrating construction of SZC compound database and AM target database, prediction of potential active compounds and targets by molecular docking combined with compound-target prediction graph (CTPG), protein-protein interaction (PPI) analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Then, the anti-inflammation experiments in vitro were performed by investigating SZC and the representative compounds regulating nitric oxide (NO), interleukin-6 (IL-6), and interleukin-10 (IL-10). Results Our findings show that SZC mainly treated AM by stimulating 28 core targets through 30 key potential active compounds, and affecting 4 crucial pathways. The treatment was associated with inflammation reaction, hormone regulation, cell adhesion, proliferation, and angiogenesis. Additionally, SZC achieved the anti-inflammatory activity by the cooperation of the compounds through inhibiting NO and IL-6, both promoting and inhibiting IL-10. Conclusion This study investigated the anti-inflammatory activity of SZC based on a systematic analysis of SZC remedying AM, which was revealed to be one of the essential mechanisms. These findings will provide valuable guidance for further research of the SZC treatment of AM, and help improve the comprehension of SZC pharmacological basis as well as AM pathogenesis.
- Published
- 2020
39. Propofol inhibits proliferation and invasion of endometriotic cells by miR-9-5p/TGFBI axis
- Author
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Yirong Zhu, Jie Song, Gang Li, Benchao Hou, Qun Zhou, and Lihua Xiao
- Subjects
Gynecological disease ,business.industry ,General Neuroscience ,Endometriosis ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Apoptosis ,medicine ,Cancer research ,General Agricultural and Biological Sciences ,Propofol ,business ,TGFBI ,medicine.drug - Abstract
Endometriosis (EM) is an estrogen-dependent, frequent benign gynecological disease, which reduces the quality of life in EM patients. Propofol regulates the apoptosis of EM. miR-9-5p is decreased i...
- Published
- 2020
40. Efficacy of Ninjin’yoeito for Preoperative Anemia, Fatigue, and Anxiety in Patients with Gynecological Disease: an Open-Label, Single-Center, Randomized Phase-II Trial
- Author
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Kenjiro Sawada, Kiyoshi Yoshino, Taro Yagi, Mayuko Miyamoto, Takuji Tomimatsu, Satoshi Nakagawa, Tadashi Kimura, Kae Hashimoto, Michiko Kodama, Tsuyoshi Takiuchi, Seiji Mabuchi, Eiji Kobayashi, and Yasuto Kinose
- Subjects
medicine.medical_specialty ,Gynecological disease ,business.industry ,Internal medicine ,medicine ,Anxiety ,Preoperative anemia ,In patient ,medicine.symptom ,Open label ,Single Center ,business - Abstract
Background: Preoperative anemia affects perioperative outcomes and often causes fatigue and psychological disorders. Therefore, anemia should be treated before a patient undergoes surgery. Ninjin’yoeito (NYT), a Japanese Kampo medicine composed of ginseng and Japanese angelica root with the other 10 herbs, is administered for anemia, fatigue and anxiety; however, there are a few reports that have prospectively examined the effects of NYT before surgery for gynecological diseases. Hence, we tended to investigate its efficacy and safety.Methods: In this open-label randomized trial, women with gynecological diseases accompanied by preoperative anemia (defined as Results: 40 patients were enrolled of whom 30 patients were finally analyzed after allocating 15 to each group. There was no difference in the characteristics between both groups. Hb significantly increased in both groups (iron supplementation group, 9.9 ± 0.8 g/dL vs. 11.9 ± 1.6 g/dL; NYT group, 9.8 ± 1.0 g/dL vs. 12.0 ± 1.0 g/dL); the difference in the elevations in Hb between both groups was statistically insignificant (P = 0.72). Contrarily, CFS (17.9 ± 10.2 vs. 8.1 ± 5.2) and VAS-A (56 mm (50–70) vs. 23 mm (6–48)) scores were significantly decreased only in the NYT group and these changes were greater in the NYT group (∆CFS, P = 0.015; ∆VAS-A, P = 0.014). Liver dysfunction occurred in one patient of the NYT group.Conclusions: For treating preoperative anemia in women with gynecological conditions, NYT administration along with iron supplementation safely and efficiently improved the preoperative anemia, fatigue and anxiety.Trial registration: jRCT1051190012 (28/April/2019, retrospectively registered).
- Published
- 2021
41. In vivo and in vitro metabolism study of traditional Chinese medicine formula Dingkun Dan in rats by using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry
- Author
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Weidong Zhang, Xiu‐xiu Dou, Shan Lin, Yuhao Zhang, Xike Xu, Xin Guo, Yanlin Liang, Zi-Qing Gao, Ying-Li Cai, and Ji Ye
- Subjects
Gynecological disease ,Clinical Biochemistry ,Administration, Oral ,Traditional Chinese medicine ,Mass spectrometry ,Biochemistry ,Mass Spectrometry ,Analytical Chemistry ,Alkaloids ,In vivo ,Drug Discovery ,Animals ,Metabolic study ,Quadrupole time of flight ,Molecular Biology ,Chromatography, High Pressure Liquid ,Flavonoids ,Pharmacology ,Chromatography ,Chemistry ,In vitro metabolism ,General Medicine ,Saporins ,Rats ,Metabolic pathway ,Metabolic Networks and Pathways ,Drugs, Chinese Herbal - Abstract
Dingkun Dan (DKD), a reputable traditional Chinese medicine formula, has been used to treat gynecological diseases and showed significant clinical effects since ancient times. However, the application and development of DKD are seriously hampered by the unclear active substances. Structural characterization of compounds absorbed in vivo and their corresponding metabolites is significant for clarifying the pharmacodynamic material basis. In this study, an integrated strategy using ultra-performance liquid chromatography, coupled with quadrupole time-of-flight mass spectrometry and UNIFI™ software, was used to identify prototypes and metabolites after oral administration of DKD in rats. As a result, a total of 261 compounds, including 140 prototypes and 121 metabolites, were tentatively characterized in rat plasma, urine, and feces. The metabolic pathways of prototypes have been studied to clarify their possible transformation process in vivo. Moreover, an in vitro metabolism study was applied for verifying the metabolites under simulating the metabolic environment in vivo. This first systematic metabolic study of DKD is important for elucidating the metabolites and metabolic pathways and could provide a scientific basis for explaining the integrative mechanism in further pharmacology study.
- Published
- 2021
42. Psychological Morbidity in Endometriosis: A Couple’s Study
- Author
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Maria da Graça Pereira, Filipa Osório, Cristina Nogueira-Silva, Ana C. Almeida, Inês Ribeiro, Helder Ferreira, and Universidade do Minho
- Subjects
Infertility ,endometriosis ,Gynecological disease ,Patients ,Health, Toxicology and Mutagenesis ,Sexual Behavior ,Population ,Endometriosis ,Disease ,Personal Satisfaction ,Marital relationship ,Hospital Anxiety and Depression Scale ,patients ,Article ,03 medical and health sciences ,0302 clinical medicine ,5. Gender equality ,Intervention (counseling) ,Surveys and Questionnaires ,Adaptation, Psychological ,medicine ,Humans ,education ,psychological morbidity ,education.field_of_study ,Science & Technology ,030219 obstetrics & reproductive medicine ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,3. Good health ,Psychological morbidity ,Sexual Partners ,030220 oncology & carcinogenesis ,Medicine ,Female ,Morbidity ,partners ,business ,Partners ,Clinical psychology - Abstract
Endometriosis is a chronic gynecological disease that impacts more than 176 million women worldwide, having a strong impact on psychological morbidity. This study aimed to evaluate the contribution of psychological morbidity, in women with endometriosis, taking into consideration the duration of the couple’s relationship and the duration of the disease and also examine whether women’s sexual satisfaction had an impact on their psychological morbidity (actor effect) and on their sexual partners’ psychological morbidity (partner effect) and vice versa. Participants were 105 women and their partners, who answered the Hospital Anxiety and Depression Scale (HADS), Couple Satisfaction Index (CSI-4) and the Global Measure of Sexual Satisfaction (GMSEX). The results revealed a direct effect between the perception of symptom severity, marital satisfaction, and women’s psychological morbidity. Sexual activity and the presence of infertility had an indirect effect on the relationship between sexual satisfaction, diagnosis duration, and psychological morbidity, respectively. Finally, women’s sexual satisfaction had a direct effect on their own and partner’s marital satisfaction that predicted less psychological morbidity, in each. Thus, multidisciplinary interventions focused on the couple’s sexual and marital relationship, as well as illness representations, are needed to promote psychological well-being in this population.
- Published
- 2021
43. Kvinnors upplevelser av endometrios : En litteraturstudie
- Abstract
Bakgrund: Endometrios är en sjukdom som drabbar 10% av alla kvinnor i världen. Endometrios har komplexa symtom och det finns fortfarande stora kunskapsluckor om sjukdomen. Syfte: Att beskriva kvinnors upplevelser av att ha sjukdomen endometrios. Metod: Studien genomfördes som en litteraturstudie med induktiv ansats, och 11 resultatartiklar inkluderades och bearbetades. Resultatartiklarna bearbetades genom att resultaten granskades, sammanställdes och kategorier skapades. Resultat: I resultatet framgick att kvinnor med endometrios upplevde många olika symtom som gav inverkan på flera aspekter av deras liv. Kvinnor upplevde att diagnosen försenades då de inte blev betrodda av hälso- och sjukvården eller av vänner och familj som kunde normalisera deras symtom. Resultatet delades in i fem huvudkategorier: Upplevelser av fysiska, psykiska och emotionella symtom, Upplevelser av mötet med hälso- och sjukvården, Upplevelser av behandlingsformer, Upplevelser av intima relationer och sexualitet och Upplevelser av att inte bli tagen på allvar. Konklusion: Endometrios kan påverka flera dimensioner av kvinnans hälsa och liv. Det är av vikt att sjukvården tillgodoser kvinnans fysiska och psykiska välbefinnande. En ökad medvetenhet om hur sjukdomen påverkar kvinnan och hennes livssituation är väsentligt i ett omvårdnadsperspektiv., Background: Endometriosis is a disease that affects 10% of all women in the world. Endometriosis generates complex symptoms and there are still substantial knowledge gaps about this disease. Objective: To describe women’s experiences of having the disease endometriosis. Method: The study was conducted as a literature study with an inductive approach, where 11 result articles were used and processed. The articles were processed by reviewing and compiling the results and thereafter categories were created. Results: In the result it appeared that women with endometriosis experienced multiple different symptoms that had impact on numerous aspects of their life. Women experienced a delay in diagnosis due to not being believed by healthcare professionals and family and friends who could normalize their symptoms. The analysis resulted in five main categories: Experiences of physical, psychological and emotional symptoms, Experiences of encounters with healthcare, Experiences of treatment, Experiences of intimate relationships and sexuality and Experiences of not being taken seriously. Conclusion: Endometriosis can impact multiple different aspects of women’s lives. It is of importance that healthcare meets the needs of the women’s psychological and physical well-being. An increased awareness of how the disease affects the woman and her life situation is essential from a nursing perspective.
- Published
- 2021
44. Kvinnors upplevelser av endometrios : En litteraturstudie
- Abstract
Bakgrund: Endometrios är en sjukdom som drabbar 10% av alla kvinnor i världen. Endometrios har komplexa symtom och det finns fortfarande stora kunskapsluckor om sjukdomen. Syfte: Att beskriva kvinnors upplevelser av att ha sjukdomen endometrios. Metod: Studien genomfördes som en litteraturstudie med induktiv ansats, och 11 resultatartiklar inkluderades och bearbetades. Resultatartiklarna bearbetades genom att resultaten granskades, sammanställdes och kategorier skapades. Resultat: I resultatet framgick att kvinnor med endometrios upplevde många olika symtom som gav inverkan på flera aspekter av deras liv. Kvinnor upplevde att diagnosen försenades då de inte blev betrodda av hälso- och sjukvården eller av vänner och familj som kunde normalisera deras symtom. Resultatet delades in i fem huvudkategorier: Upplevelser av fysiska, psykiska och emotionella symtom, Upplevelser av mötet med hälso- och sjukvården, Upplevelser av behandlingsformer, Upplevelser av intima relationer och sexualitet och Upplevelser av att inte bli tagen på allvar. Konklusion: Endometrios kan påverka flera dimensioner av kvinnans hälsa och liv. Det är av vikt att sjukvården tillgodoser kvinnans fysiska och psykiska välbefinnande. En ökad medvetenhet om hur sjukdomen påverkar kvinnan och hennes livssituation är väsentligt i ett omvårdnadsperspektiv., Background: Endometriosis is a disease that affects 10% of all women in the world. Endometriosis generates complex symptoms and there are still substantial knowledge gaps about this disease. Objective: To describe women’s experiences of having the disease endometriosis. Method: The study was conducted as a literature study with an inductive approach, where 11 result articles were used and processed. The articles were processed by reviewing and compiling the results and thereafter categories were created. Results: In the result it appeared that women with endometriosis experienced multiple different symptoms that had impact on numerous aspects of their life. Women experienced a delay in diagnosis due to not being believed by healthcare professionals and family and friends who could normalize their symptoms. The analysis resulted in five main categories: Experiences of physical, psychological and emotional symptoms, Experiences of encounters with healthcare, Experiences of treatment, Experiences of intimate relationships and sexuality and Experiences of not being taken seriously. Conclusion: Endometriosis can impact multiple different aspects of women’s lives. It is of importance that healthcare meets the needs of the women’s psychological and physical well-being. An increased awareness of how the disease affects the woman and her life situation is essential from a nursing perspective.
- Published
- 2021
45. The female reproductive tract virome: understanding the dynamic role of viruses in gynecological health and disease
- Author
-
Cynthia L. Monaco and Ferralita S. Madere
- Subjects
endocrine system ,Gynecological disease ,Virome ,Microbiota ,Infant, Newborn ,Disease ,Biology ,Bioinformatics ,Article ,Human health ,Virology ,Viruses ,Humans ,Human virome ,Bacteriophages ,Female ,Neonatal health ,Female Reproductive Tract ,Symbiosis - Abstract
The human body is inhabited by a large and complex network of commensal and predatory eukaryotic viruses and bacteriophages collectively termed the virome. Despite being the most abundant and genetically diverse biological entities on the planet, the impact of viruses on human health especially within the female reproductive tract (FRT) remains under-studied. To better appreciate current knowledge regarding the dynamic role of viruses in FRT health and disease, in this review we highlight the known constituents of the FRT virome, transkingdom interactions within the FRT and their influence on gynecological disease. A better understanding of the FRT virome may pave the way toward improved outcomes in gynecological, reproductive, and neonatal health.
- Published
- 2021
46. Stigma and Endometriosis: A Brief Overview and Recommendations to Improve Psychosocial Well-Being and Diagnostic Delay
- Author
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Irene O Aninye, Stacey A. Missmer, Omar T Sims, and Jhumka Gupta
- Subjects
endometriosis ,Delayed Diagnosis ,Health, Toxicology and Mutagenesis ,Social Stigma ,Endometriosis ,Psychological intervention ,Stigma (botany) ,Review ,chronic pelvic pain ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,women’s health ,Health care ,Medicine ,Humans ,030212 general & internal medicine ,gynecological disease ,030219 obstetrics & reproductive medicine ,psychosocial well-being ,business.industry ,Pelvic pain ,Public Health, Environmental and Occupational Health ,medicine.disease ,diagnostic delay ,Mental health ,Mental Health ,stigma ,Quality of Life ,Female ,medicine.symptom ,business ,Psychosocial ,Clinical psychology - Abstract
Endometriosis is a chronic gynecological disease that affects approximately 1 in 10 women of reproductive age. Symptoms of severe pelvic pain, infertility, fatigue, and abnormal menstruation can cause significant negative effects on an individual’s physical and mental health, including interactions with their family, friends, and health care providers. Stigma associated with endometriosis has been under-studied and is rarely discussed in current literature. Herein, this paper aims to provide a brief overview of published literature to explore and establish the plausibility of stigma as a driver of suboptimal psychosocial well-being and diagnostic delay among individuals living with endometriosis. We present the clinical characteristics and physical and mental health consequences associated with endometriosis, highlight several theoretical constructs of stigma, and review the limited studies documenting women’s lived experiences of endometriosis-related stigma. To mitigate harmful effects of this phenomenon, we recommend increasing efforts to assess the prevalence of and to characterize endometriosis-related stigma, implementing awareness campaigns, and developing interventions that combat the multidimensional negative effects of stigma on timely care, treatment, and quality of life for individuals living with endometriosis.
- Published
- 2021
47. P–454 Oocyte vitrification for fertility preservation in women with benign gynecological disease: French national clinical guidelines with a modified Delphi consensus process
- Author
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L Dirian, I Chavanaz-Lacheray, Enora Le Roux, Christophe Poncelet, A S Gremeau, Blandine Courbiere, M Peigné, Jean-Luc Pouly, H Creux, Xavier Fritel, J Montagut, E Mathie. D’Argent, Catherine Patrat, A Torre, and Arnaud Fauconnier
- Subjects
medicine.medical_specialty ,Gynecological disease ,Obstetrics ,business.industry ,Rehabilitation ,Modified delphi ,Obstetrics and Gynecology ,Oocyte ,medicine.anatomical_structure ,Reproductive Medicine ,medicine ,Vitrification ,Fertility preservation ,business - Abstract
Study question Is there consensual clinical practices about fertility preservation (FP) for benign gynecological diseases BGD)? Summary answer A consensus study using the modified Delphi method identified 28 consensual practices concerning oocyte vitrification for fertility preservation in women with benign gynecological disease. What is known already Clinical Practical international guidelines are still published in oncology for offering standardized information and care for adults and children with cancer. Recently, the ESHRE Female Fertility Preservation Guideline Development Group published recommendations for healthcare professionals involved in fertility preservation for post-pubertal women and transgender adolescents and young adults. However, benign gynecological indications weren’t distinctly individualized of malignant conditions. There’s a lack of large cohort studies assessing the risks and outcome of FP for benign gynecological diseases. Healthcare professionals need consensus for defining the “good” indications of FP for benign gynecological diseases that could impair fertility. Study design, size, duration A steering group composed by 14 healthcare professionals and a patient representative with lived experience of endometriosis identified 42 potential practices concerning fertility preservation for benign gynecological disease. Then, 114 key stakeholders including various healthcare professionals (n = 108) and patient representatives(n = 6) were asked to answer at two rounds of a modified Delphi via an online survey from February to September 2020. Participants/materials, setting, methods Participants had to score 42 items for the first round and 31 for the second round using a nine-point Likert scale. These statements were distributed into five categories: Information to deliver to age-reproductive women with a BGD (n = 9), technical aspect of fertility preservation for BGD (n = 6), indications of FP for endometriosis (n = 13), indications of FP for none-endometriosis BGD (n = 10), idiopathic diminished ovarian reserve in the absence of gynecologic and endocrinologic diseases (n = 4). Main results and the role of chance Survey response of stakeholders was 75% (86 out of 114) for the round 1 and 87% (75 out of 86) for the round 2. Consensus recommendations were achieved for 28 items, and no consensus between stakeholders was achieved in the remaining items. Stakeholders rated the importance of an age-specific information concerning the risk of diminished ovarian reserve after surgery and the necessity to inform about the benefice/ risk balance of oocyte vitrification, in particular about the chance of live-birth according to the age at the time of oocyte vitrification. They endorsed oocyte vitrification as the reference FP technique for those benign indications. Experts rejected to determine lower and upper age limits in women for fertility preservation. FP shouldn’t be offered in rAFS stages I and II endometriosis without endometriomas. Limitations, reasons for caution Experts were only French native speakers from France, and Belgium. It would have been interesting to conduct this survey with experts from other continents. Wider implications of the findings: At our knowledge, we present here the first guideline s focusing on FP in women with BGD, following a designed scientific Delphi procedure. These guidelines could be useful for gynecologists to better inform women with benign gynecological diseases about the indication or not to offer a FP procedure. Trial registration number Not applicable
- Published
- 2021
48. Gynecological Disease Diagnosis Expert System Using the Web-Based Dempster Shafer Method
- Author
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Ade Eviyanti and Lola Herawati
- Subjects
Uterine disease ,Gynecological disease ,business.industry ,Computer science ,Advanced stage ,Disease ,medicine.disease ,computer.software_genre ,Expert system ,Knowledge base ,Dempster–Shafer theory ,medicine ,Medical emergency ,Use of technology ,business ,computer - Abstract
Uterine disease is a disease that generally attacks female reproduction. Most women know a disease that is in their womb when the disease is declared severe or so-called advanced stage. With this expert system, it is hoped that human uterine diseases can be detected early and can minimize the occurrence of more dangerous diseases. The method used in this expert system is the Dempster Shafer calculation method. This expert system works by entering the symptoms experienced by the patient after which the system will work according to the calculations determined by the expert who entered the knowledge base. The result of this research is to build an expert system for diagnosis of gynecology using a website-based dempster shafer. This website can be used as the use of technology so that it can be used to diagnose uterine diseases precisely and accurately, so that people with gynecological diseases are handled more quickly from an early age.
- Published
- 2021
49. Intramedullary Endometriosis of the Conus Medullaris
- Author
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Ricardo Teodoro Beck, Francisco Carbonar, Ricardo A. Hanel, Mauren Beatriz Frazon Carbonar, and Theodoro B Beck
- Subjects
endometriosis ,medicine.medical_specialty ,Gynecological disease ,Neurosurgery ,Endometriosis ,Disease ,030204 cardiovascular system & hematology ,law.invention ,paresthesia ,Intramedullary rod ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Spinal canal ,conus medullaris ,business.industry ,General Engineering ,medicine.disease ,Conus medullaris ,medicine.anatomical_structure ,Oncology ,Obstetrics/Gynecology ,Uterine cavity ,Radiology ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Endometriosis (EM) is a common gynecological disease characterized by endometrial-like tissue outside the uterine cavity. We report a case of intramedullary EM, a rare condition with only seven similar cases reported until today. MRI showed a mass-like lesion within the spinal canal at the L1-L2 levels and the histological and immunohistochemical features were characteristic of intraspinal endometriosis (IEM). A review of the relevant literature and a comparison between our case and seven other similar cases were made. Intraspinal EM must be recognized as a potential cause of periodic neurological signs and symptoms in young and middle-aged women. Timely intervention and appropriate management can result in control of the disease and an improvement in neurological functions.
- Published
- 2021
50. From the history of polycystic ovary syndrome
- Author
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D. A. Kiryushkina
- Subjects
Embryology ,medicine.medical_specialty ,kronid fedorovich slavyanskiy ,Gynecological disease ,endocrine system diseases ,media_common.quotation_subject ,Ovary ,Fertility ,Anovulation ,medicine ,antonio wallisneri ,ovarian wedge resection ,Acne ,hirsutism ,media_common ,Gynecology ,michael leventhal ,business.industry ,Hyperandrogenism ,Obstetrics and Gynecology ,Gynecology and obstetrics ,sclerocystic ovaries ,medicine.disease ,Polycystic ovary ,female genital diseases and pregnancy complications ,medicine.anatomical_structure ,Reproductive Medicine ,polycystic ovary syndrome ,RG1-991 ,sergey kuzmich lesnoy ,business ,bilateral electrocautery of the ovaries diathermy ,irving stein - Abstract
Polycystic ovary syndrome (PCOS) is a gynecological disease manifested in polycystic ovarian morphology, oligo/ anovulation, hyperandrogenism, hirsutism, alopecia, and acne. PCOS affects 5–10 % of women of reproductive age. The first histological description of polycystic ovaries was made by Antonio Vallisneri. Then, Kronid Fedorovich Slavyanskiy, for the first time, described the clinical picture of PCOS, and Sergey Kuzmich Lesnoy proposed ovary wedge resection for surgical treatment. Irving Stein and Michael Leventhal studied the PCOS symptom complex and provided the recommendations on its diagnosis and treatment to restore normal menstrual cycle and fertility in such patients.
- Published
- 2019
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