Author: "Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)" - Searchworks@Jio Institute Digital Library Search Results

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1. Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey

Author: Susan C Short, Dieta Brandsma, Karin Piil, Martin J. van den Bent, Linda Dirven, Emilie Le Rhun, Florien W. Boele, Michael Weller, Marilena Theodorou, Simone P Niclou, Roberta Rudà, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University hospital of Zurich [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Luxembourg Institute of Health (LIH), Leeds Institute of Cancer and Pathology [U.K.], University of Leeds, Copenhagen University Hospital, City of Health and Science University Hospital [Turin, Italy], University of Cyprus (UCY), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Leiden University Medical Center (LUMC), Haaglanden Medical Center [La Haye, Pays-Bas] (HMC), University of Zurich, Le Rhun, Emilie, SALZET, Michel, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University of Cyprus [Nicosia] (UCY), Universiteit Leiden, Neurology, INSERM, Université de Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM], Luxembourg Institute of Health [LIH], University of Copenhagen = Københavns Universitet [UCPH], Università degli studi di Torino = University of Turin [UNITO], University of Cyprus [Nicosia] [UCY], Erasmus University Medical Center [Rotterdam] [Erasmus MC], and Leiden University Medical Center [LUMC]
Subjects: Gerontology, leadership, Inequality, Neuro oncology, media_common.quotation_subject, [SDV]Life Sciences [q-bio], education, Medicine (miscellaneous), 610 Medicine & health, 03 medical and health sciences, 0302 clinical medicine, 5. Gender equality, Health care, Medicine, 030212 general & internal medicine, equality, disparities, women, oncology, media_common, business.industry, Perspective (graphical), Work–life balance, 2701 Medicine (miscellaneous), Life balance, Original Articles, 10040 Clinic for Neurology, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, Workforce, business
Abstract: Background Women represent an increasing proportion of the overall workforce in medicine but are underrepresented in leadership roles. Methods To explore gender inequalities and challenges in career opportunities, a web-based survey was conducted among the membership of the European Association of Neuro-Oncology and the Brain Tumor Group of the European Organisation for Research and Treatment of Cancer. Results A total of 228 colleagues responded to the survey: 129 women (median age 45 years; range, 25-66 years) and 99 men (median age 48 years; range, 24-81 years); 153 participants (67%) were married and 157 participants (69%) had at least 1 child. Women less often declared being married (60% vs 77%, P = .007) or having a child (63% vs 77%, P = .024). Men more frequently had a full-time position (88% vs 75%, P = .036). Women and men both perceived an underrepresentation of women in leadership positions. Half of participants agreed that the most important challenges for women are leading a team and obtaining a faculty position. Fewer women than men would accept such a position (42% vs 56%). The main reasons were limited time for career and an inappropriate work and life balance. Women specifically cited negative discrimination, limited opportunities, and lack of self-confidence. Discrimination of women at work was perceived by 64% of women vs 47% of men (P = .003). Conclusion Women are perceived as experiencing more difficulties in acquiring a leadership position. Personal preferences may account for an underrepresentation of women in leadership positions, but perceived gender inequalities extend beyond disparities of access to leadership.
Published: 2020

2. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak

Author: Kerleroux, Basile, Fabacher, Thibaut, Bricout, Nicolas, Moïse, Martin, Testud, Benoit, Vingadassalom, Sivadji, Ifergan, Héloïse, Janot, Kévin, Consoli, Arturo, Ben Hassen, Wagih, Shotar, Eimad, Ognard, Julien, Charbonnier, Guillaume, L’Allinec, Vincent, Guédon, Alexis, Bolognini, Federico, Marnat, Gaultier, Forestier, Géraud, Rouchaud, Aymeric, Pop, Raoul, Raynaud, Nicolas, Zhu, François, Cortese, Jonathan, Chalumeau, Vanessa, Berge, Jérome, Escalard, Simon, Boulouis, Grégoire, Chivot, Cyril, Hanafi, Riyad, Pasco, Anne, Girot, Jean-Baptiste, Biondi, Alessandra, Di Caterino, Fortunato, Primikiris, Panagiotis, Vitale, Giovanni, Bonnet, Louise, Gariel, Florent, Barreau, Xavier, Debruxelles, Sabrina, Lucas, Ludovic, Menegon, Patrice, Olindo, Stéphane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Sibon, Igor, Veunac, Louis, Gentric, Jean-Christophe, Barbier, Charlotte, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Schneckenburger, Romain, Touze, Emmanuel, Delaitre, Mariette, Lebendinsky, Pablo, Musacchio, Mariano, Ricolfi, Frédéric, Thouant, Pierre, Caparros, François, Casolla, Barbara, Della Schiava, Lucie, Dequatre, Nelly, Henon, Hilde, Pasi, Marco, Kazemi, Apolline, Bala, Fouzi, Estrade, Laurent, Mounayer, Charbel, Saleme, Susanna, Macian-Montoro, Francisco, Eker, Omer, Cotton, François, Blanc-Lasserre, Karine, Cakmak, Serkan, Cho, Tae-Hee, Derex, Laurent, Lukaszewicz, Anne-Claire, Mechtouff, Laura, Nighoghossian, Norbert, Philippeau, Frédéric, Riva, Roberto, Turjman, Francis, Vallet, Anne-Evelyne, Carle, Xavier, Dory-Lautrec, Philippe, Reyre, Anthony, Hak, Jean-François, Brunel, Hervé, Benali, Amel, Collemiche, François-Louis, Dargazanli, Cyril, Cagnazzo, Frederico, Derraz, Imad, Arquizan, Caroline, Corti, Lucas, Costalat, Vincent, Gaillard, Nicolas, Gascou, Grégory, Lefèvre, Pierre-Henri, Mourand, Isabelle, Riquelme, Carlos, Derelle, Anne Laure, Gory, Benjamin, Liao, Liang, Tonnelet, Romain, Anxionnat, René, Bonnerot, Mathieu, Bracard, Serge, Braun, Marc, Humbertjean, Lisa, Lacour, Jean-Christophe, Mione, Gioia, Planel, Sophie, Richard, Sébastien, Riou-Comte, Nolwenn, Schmitt, Emmanuelle, Bourcier, Romain, Detraz, Lili, Desal, Hubert, Alexandre, Pierre-Louis, Daumas-Duport, Benjamin, Lenoble, Cédric, Roy, Monica, Coskun, Oghuzan, Di Maria, Frederico, Lapergue, Bertrand, Rodesch, Georges, Wang, Adrien, Weisenburger-Lile, David, Zimatore, Sergio, Ajili, Nadia, Buard, Géraldine, Evrard, Serge, Gorza, Lucas, Gratieux, Julie, Leguen, Morgan, Marinier, Sylvie, Pico, Fernando, Poll, Roxanna, Rakotoharinandrasana, Haja, Tassan, Philippe, Tchikviladze, Maya, Delvoye, François, Hebert, Solène, Blanc, Raphaël, Ciccio, Gabriele, Desilles, Jean-Philippe, Maier, Benjamin, Mazighi, Mikael, Piotin, Michel, Redjem, Hocine, Smajda, Stanislas, Ben Maacha, Malek, Corabianu, Ovide, De Broucker, Thomas, Ille, Olivier, Manchon, Eric, Obadia, Michael, Obadia, Mickael, Raynouard, Igor, Peres, Roxanne, Sabben, Candice, Smadja, Didier, Taylor, Guillaume, Thion, Laurie-Anne, Lecler, Augustin, Denier, Christian, Caroff, Jildaz, Chassin, Olivier, Spelle, Laurent, Venditti, Laura, Aymard, Armand, Betty, Jean, Civelli, Vittorio, Eliezer, Michael, Fantoni, Matteo, Houdart, Emmanuel, Labeyrie, Marc-Antoine, Saint Maurice, Jean-Pierre, Kalsoum, Erwah, Pacini, Aurelien, Ramadane, Chawkat, Tuilier, Titien, Villain, Adrien, Clarencon, Frédéric, Degos, Vincent, Elhfnawy, Ahmed, Elhorany, Mahmoud, Lenck, Stéphanie, Premat, Kevin, Sourour, Nader-Antoine, Alamowitch, Sonia, Baronnet, Flore, Crozier, Sophie, Deltour, Sandrine, Leger, Anne, Rosso, Charlotte, Pyatigorskaya, Nadya, Rodriguez Regent, Christine, Trystram, Denis, Naggara, Olivier, Seners, Pierre, Turc, Guillaume, Edjlali, Myriam, Agbonon, Rémi, Alotaibi, Mohammed, Sonchet, Antoine, Oppenheim, Catherine, Meder, Jean François, Benzakoun, Joseph, Legrand, Laurence, Fauché, Cédric, Velasco, Stéphane, Manceau, Pierre François, Moulin, Sebastien Solène Soize, Ferré, Jean-Christophe, Paya, Christophe, Eugene, François, Gauvrit, Jean-Yves, Langnier-Lemercier, Sophie, Lassale, Maria, Raoult, helene, Ronziere, Thomas, Tracol, Clément, Vannier, Stéphane, Burel, Julien, Le Moal, Julien, Papagiannaki, Chrysanthi, Aggour, Mohamed, Sachet, Marina, Boutet, Claire, Beaujeux, Remy, Hasiu, Anca, Manisor, Monica, Mihoc, Dan, Kremer, Stéphane, Arteaga, Charles, Gazzola, Sébastien, Darcourt, Jean, Cognard, Christophe, Bonneville, Fabrice, Christine Januel, Anne, Olivot, Jean-Marc, Raposo, Nicolas, Viguier, Alain, Bibi, Richard, Boustia, Fakhreddine, Herbreteau, Denis, Maldonado, Igor, Narata, Ana-Paula, Service de neuroradiologie [Paris], Hôpital Sainte-Anne, CHU Strasbourg, Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neuroradiologie diagnostique et interventionnelle, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de neuroradiologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch], Hôpital Foch [Suresnes], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neuroradiologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Département de Neuro-Radiologie [Bordeaux] (DNR - Bordeaux), CHU Bordeaux [Bordeaux], Service de Neuroradiologie interventionnelle [CHU Limoges], CHU Limoges, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Service de neurologie [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Neuroradiologie [CHU de Bicêtre], Hôpital Rothschild [AP-HP], Faculté de Médecine [Nancy], Université de Lorraine (UL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rothschild [AP-HP], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Service de neuroradiologie diagnostique et fonctionnelle [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
Subjects: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76–0.82]; P
Published: 2020

3. How did lomustine become standard of care in recurrent glioblastoma?

Author: Michael Weller, Emilie Le Rhun, University hospital of Zurich [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER, University of Zurich, Weller, Michael, INSERM, Université de Lille, Universität Zürich [Zürich] = University of Zurich [UZH], Département de neurologie [Lille], and Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Subjects: 0301 basic medicine, Oncology, medicine.medical_specialty, CCNU, Bevacizumab, Alkylation, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Salvage therapy, 610 Medicine & health, Procarbazine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lomustine, Internal medicine, Regorafenib, Antineoplastic Combined Chemotherapy Protocols, PCV Regimen, Humans, 2741 Radiology, Nuclear Medicine and Imaging, Medicine, Radiology, Nuclear Medicine and imaging, Repair, MGMT, DNA, Randomized Controlled Trials as Topic, Chemotherapy, Temozolomide, Brain Neoplasms, business.industry, General Medicine, 10040 Clinic for Neurology, 3. Good health, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, 2730 Oncology, Neoplasm Recurrence, Local, Glioblastoma, business, medicine.drug
Abstract: International audience; Glioblastomas are the most common malignant primary intrinsic brain tumors. Their incidence increases with age, and males are more often affected. First-line management includes maximum safe surgical resection followed by involved-field radiotherapy plus concomitant and six cycles of maintenance temozolomide chemotherapy. Standards of care at recurrence are much less well defined. Minorities of patients are offered second surgery or re-irradiation, but data on a positive impact on survival from randomized trials are lacking. The majority of patients who are eligible for salvage therapy receive systemic treatment, mostly with nitrosourea-based regimens or, depending on availability, bevacizumab alone or in various combinations. In clinical trials, lomustine alone has been increasingly used as a control arm, assigning this drug a standard-of-care position in the setting of recurrent glioblastoma. Here we review the activity of lomustine in the treatment of diffuse gliomas of adulthood in various settings. The most compelling data for lomustine stem from three randomized trials when lomustine was combined with procarbazine and vincristine as the PCV regimen in the newly diagnosed setting together with radiotherapy; improved survival with PCV was restricted to patients with isocitrate dehydrogenase-mutant tumors. No other agent with the possible exception of regorafenib has shown superior activity to lomustine in recurrent glioblastoma, but activity is largely restricted to patients with tumors with O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation. Hematological toxicity, notably thrombocytopenia often limits adequate exposure.
Published: 2020

4. Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?

Author: Emilie Le Rhun, Florence Lefranc, Robert Kiss, Michael Weller, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Fonds National de la Recherche Scientifique [Bruxelles] (FNRS), Universität Zürich [Zürich] = University of Zurich (UZH), University hospital of Zurich [Zurich], Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), SALZET, Michel, University of Zurich, and Lefranc, Florence
Subjects: 0301 basic medicine, Programmed cell death, [SDV]Life Sciences [q-bio], 610 Medicine & health, Extracellular matrix, 03 medical and health sciences, Cell Movement, Glioma, microRNA, Extracellular, 2741 Radiology, Nuclear Medicine and Imaging, Animals, Humans, Medicine, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, Imagerie médicale, radiologie, tomographie, neoplasms, Ion channel, Brain Neoplasms, business.industry, General Medicine, medicine.disease, 10040 Clinic for Neurology, 3. Good health, Cell biology, [SDV] Life Sciences [q-bio], Cancérologie, 030104 developmental biology, Oncology, 2730 Oncology, Signal transduction, Glioblastoma, business, Intracellular
Abstract: Purpose: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle. Methods: This review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis. Results: This review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed. Conclusion: Our view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma., SCOPUS: re.j, info:eu-repo/semantics/published
Published: 2018

5. Farewell to monomodality treatment in patients with WHO lower grade glioma?

Author: Thierry Gorlia, Le Rhun E, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University hospital of Zurich [Zurich], Universität Zürich [Zürich] = University of Zurich (UZH), Universitätsspital Zürich (USZ), EORTC Headquarters [Brussels, Belgium], SALZET, Michel, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
Subjects: Oncology, Male, Cancer Research, medicine.medical_specialty, [SDV]Life Sciences [q-bio], MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Text mining, Internal medicine, Glioma, Temozolomide, Medicine, Humans, In patient, Antineoplastic Agents, Alkylating, ComputingMilieux_MISCELLANEOUS, Randomized Controlled Trials as Topic, Neoplasm Grading, Lower grade, Radiotherapy, business.industry, Brain Neoplasms, Chemoradiotherapy, medicine.disease, 3. Good health, Clinical trial, Dacarbazine, [SDV] Life Sciences [q-bio], Clinical Trials, Phase III as Topic, 030220 oncology & carcinogenesis, Female, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: International audience; No abstract available
Published: 2018

6. Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer

Author: Audrey Mailliez, Emmanuelle Tresch, Jacques Bonneterre, Nicolas Bertrand, Matthias Preusser, Aurelie Dumont, Marie-Cécile Le Deley, Françoise Revillion, Emilie Le Rhun, Michael Weller, Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER, Comprehensive Cancer Center [Vienna, Austria], Institute of Cancer Research [Vienna, Austria]-Medizinische Universität Wien = Medical University of Vienna, Medizinische Universität Wien = Medical University of Vienna, Universität Zürich [Zürich] = University of Zurich (UZH), SALZET, Michel, Université de Lille-UNICANCER, Medizinische Universität Wien = Medical University of Vienna-Institute of Cancer Research [Vienna, Austria], University of Zurich, and Le Rhun, Emilie
Subjects: 0301 basic medicine, Oncology, Cancer Research, PTEN, Time Factors, [SDV]Life Sciences [q-bio], AKT1, Predisposition, AKT2, Kaplan-Meier Estimate, Metastasis, Central Nervous System Neoplasms, 0302 clinical medicine, Risk Factors, Medicine, 1306 Cancer Research, 10. No inequality, biology, TOR Serine-Threonine Kinases, Brain, Middle Aged, Metastatic breast cancer, 3. Good health, [SDV] Life Sciences [q-bio], Phenotype, 030220 oncology & carcinogenesis, 2730 Oncology, Female, Sample collection, Adult, medicine.medical_specialty, Cerebral, Leptomeningeal, 610 Medicine & health, Breast Neoplasms, Polymorphism, Single Nucleotide, Risk Assessment, Disease-Free Survival, 03 medical and health sciences, Young Adult, Breast cancer, Genetic, Internal medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, PI3K/AKT/mTOR pathway, Aged, business.industry, Prevention, medicine.disease, 10040 Clinic for Neurology, 030104 developmental biology, biology.protein, SNP, Phosphatidylinositol 3-Kinase, business, Prediction, Proto-Oncogene Proteins c-akt
Abstract: International audience; Introduction: The PI3K-AKT-mTOR pathway may be involved in the development of central nervous system (CNS) metastasis from breast cancer. Accordingly, herein we explored whether single nucleotide polymorphisms (SNPs) of this pathway are associated with altered risk of CNS metastasis formation in metastatic breast cancer patients.Methods: The GENEOM study (NCT00959556) included blood sample collection from breast cancer patients treated in the neoadjuvant, adjuvant or metastatic setting. We identified patients with CNS metastases for comparison with patients without CNS metastasis, defined as either absence of neurological symptoms or normal brain magnetic resonance imaging (MRI) before death or during 5-year follow-up. Eighty-eight SNPs of phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian (or mechanistic) target of rapamycin (mTOR) pathway genes were selected for analysis: AKT1 (17 SNPs), AKT2 (4), FGFR1 (2), mTOR (7), PDK1 (4), PI3KR1 (11), PI3KCA (20), PTEN (17), RPS6KB1 (6).Results: Of 342 patients with metastases, 207 fulfilled the inclusion criteria: One-hundred-and-seven patients remained free of CNS metastases at last follow-up or date of death whereas 100 patients developed CNS metastases. Among clinical parameters, hormonal and human epidermal growth factor receptor-2 (HER2) status as well as vascular tumour emboli was associated with risk of CNS metastasis. Only PI3KR1-rs706716 was associated with CNS metastasis in univariate analysis after Bonferroni correction (p < 0.00085). Multivariate analysis showed associations between AKT1-rs3803304, AKT2-rs3730050, PDK1-rs11686903 and PI3KR1-rs706716 and CNS metastasis .Conclusion: PI3KR1-rs706716 may be associated with CNS metastasis in metastatic breast cancer patients and could be included in a predictive composite score to detect early CNS metastasis irrespective of breast cancer subtype.
Published: 2017

7. Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli

Author: Alsaleh, Ghada, Nehmar, Ramzi, Blüml, Stephan, Schleiss, Cédric, Ostermann, Eleonore, Dillenseger, Jean-Philippe, Sayeh, Amira, Choquet, Philippe, Dembélé, Doulaye, François, Antoine, Salmon, Jean-Hugues, Paul, Nicodème, Schabbauer, Gernot, Bierry, Guillaume, Meyer, Alain, Gottenberg, Jacques-Eric, Haas, Gabrielle, Pfeffer, Sébastien, Vallat, Laurent, Sibilia, Jean, Bahram, Seiamak, Georgel, Philippe, Physiopathologie des arthrites, Université Louis Pasteur - Strasbourg I, Research Center for Molecular Medicine of the Austrian Academy of Sciences [Vienna, Austria] (CeMM ), Austrian Academy of Sciences (OeAW), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Préclinique-UF6237, Pôle d'imagerie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Reims (CHU Reims), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Rheumatology [CHU Strasbourg], CHU Strasbourg, Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Immunologie cellulaire et tissulaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [Strasbourg], and CHU Strasbourg-Hôpital de Hautepierre [Strasbourg]
Subjects: Inflammation, Ribonuclease III, [SDV]Life Sciences [q-bio], Physique [physics]/Mécanique [physics], Apoptosis, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Synoviocytes, Arthritis, Rheumatoid, DEAD-box RNA Helicases, Mice, Sciences du Vivant [q-bio]/Autre [q-bio.OT], Gene Expression Regulation, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS
Abstract: OBJECTIVE: While the regulatory role of individual microRNAs (miRNAs) in rheumatoid arthritis (RA) is well established, the role of DICER1 in the pathogenesis of the disease has not yet been investigated. The purpose of this study was to analyze the expression of factors involved in miRNA biogenesis in fibroblast-like synoviocytes (FLS) from RA patients and to monitor the arthritis triggered by K/BxN serum transfer in mice deficient in the Dicer gene (Dicer(d/d) ). METHODS: The expression of genes and precursor miRNAs was quantified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). MicroRNA macroarray profiling was monitored by qRT-PCR. Cytokines were quantified by enzyme-linked immunosorbent assay. Experimental arthritis in mice was achieved by the transfer of serum from K/BxN donors. Apoptosis was quantified using an enzyme-linked immunosorbent assay. RESULTS: We found decreased DICER1 and mature miRNA expression in synovial fibroblasts from RA patients. These cells were hyperresponsive to lipopolysaccharide, as evidenced by their increased interleukin-6 secretion upon stimulation. Experimental serum-transfer arthritis in Dicer(d/d) mice confirmed that an unbalanced biogenesis of miRNAs correlated with an enhanced inflammatory response. Synoviocytes from both RA patients and Dicer(d/d) mice exhibited increased resistance to apoptotic stimuli. CONCLUSION: The findings of this study further substantiate the important role of DICER1 in the maintenance of homeostasis and the regulation of inflammatory responses.
Published: 2016

8. MRI atlas of the human hypothalamus

Author: Didier Dewailly, Serge Blond, Eglantine Balland, Vincent Prevot, Pierre Besson, Patrice Jissendi, Jean Paul Francke, J.-P. Pruvo, Marc Baroncini, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Service de neurochirurgie, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire d'anatomie, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'endocrinologie, gynécologie et médecine de la reproduction, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, and Prevot, Vincent
Subjects: Male, human hypothalamus, anatomy, Cognitive Neuroscience, Hypothalamus, MESH: Atlases as Topic, Anterior commissure, Biology, Brain mapping, MESH: Magnetic Resonance Imaging, coronal plane, White matter, Young Adult, 03 medical and health sciences, Atlases as Topic, 0302 clinical medicine, medicine, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Anatomy, Artistic, MESH: Brain Mapping, 030304 developmental biology, 2. Zero hunger, Brain Mapping, 0303 health sciences, MESH: Humans, medicine.diagnostic_test, Fornix, Magnetic resonance imaging, Anatomy, Magnetic Resonance Imaging, MESH: Hypothalamus, MESH: Anatomy, Artistic, MESH: Male, 3. Good health, medicine.anatomical_structure, Ventromedial nucleus of the hypothalamus, Neurology, MESH: Young Adult, Coronal plane, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Female, Neuroscience, Nucleus, 030217 neurology & neurosurgery, MRI
Abstract: International audience; Gaining new insights into the anatomy of the human hypothalamus is crucial for the development of new treatment strategies involving functional stereotactic neurosurgery. Here, using anatomical comparisons between histology and magnetic resonance images of the human hypothalamus in the coronal plane, we show that discrete gray and white hypothalamic structures are consistently identifiable by MRI. Macroscopic and microscopic images were used to precisely annotate the MRI sequences realized in the coronal plane in twenty healthy volunteers. MRI was performed on a 1.5 T scanner, using a protocol including T1-weighted 3D fast field echo, T1-weighted inversion-recovery, turbo spin echo and T2-weighted 2D fast field echo imaging. For each gray matter structure as well as for white matter bundles, the different MRI sequences were analyzed in comparison to each other. The anterior commissure and the fornix were often identifiable, while the mammillothalamic tract was more difficult to spot. Qualitative analyses showed that MRI could also highlight finer structures such as the paraventricular nucleus, the ventromedial nucleus of the hypothalamus and the infundibular (arcuate) nucleus, brain nuclei that play key roles in the regulation of food intake and energy homeostasis. The posterior hypothalamic area, a target for deep brain stimulation in the treatment of cluster headaches, was readily identified, as was the lateral hypothalamic area, which similar to the aforementioned hypothalamic nuclei, could be a putative target for deep brain stimulation in the treatment of obesity. Finally, each of the identified structures was mapped to Montreal Neurological Institute (MNI) space.
Published: 2012

9. Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

Author: Lesage, S, Condroyer, C, Lannuzel, A, Lohmann, E, Troiano, A, Tison, F, Damier, P, Thobois, S, Ouvrard-Hernandez, A-M, Rivaud-Péchoux, S, Brefel-Courbon, C, Destée, A, Tranchant, C, Romana, M, Leclere, L, Dürr, A, Brice, A, French Parkinson's Disease Genetics Study Group, Neurologie et thérapeutique expérimentale, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Service de neurologie, Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-CHU Bordeaux [Bordeaux], Clinique neurologique, Hôpital Laennec, Service de neurologie C [Hôpital Pierre Wertheimer - HCL], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Pharmacogénétique et abords thérapeutiques des maladies héréditaires, Université des Antilles et de la Guyane (UAG)-Université Paris Diderot - Paris 7 (UPD7)-IFR2-Institut National de la Santé et de la Recherche Médicale (INSERM), Université des Antilles et de la Guyane (UAG), French Parkinson's Disease Genetics Study Group, ANR-05-NEUR-0019,LRRK2 in PD,Pathologie moléculaire et modèles murins du gène LRRK2, impliqué dans la maladie de Parkinson(2005), Pollak, Pierre, Fédération des Maladies du Système Nerveux, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Savasta, Marc, Neurosciences, neurologie et psychiatrie - Pathologie moléculaire et modèles murins du gène LRRK2, impliqué dans la maladie de Parkinson - - LRRK2 in PD2005 - ANR-05-NEUR-0019 - NEURO - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Proband, MESH: Chi-Square Distribution, Parkinson's disease, DNA Mutational Analysis, [SDV.GEN] Life Sciences [q-bio]/Genetics, medicine.disease_cause, Exon, MESH: Aged, 80 and over, 0302 clinical medicine, Gene Frequency, European Continental Ancestry Group/genetics, MESH: DNA Mutational Analysis, Genetics (clinical), Aged, 80 and over, MESH: Aged, Genetics, LRRK2 Gene, 0303 health sciences, Mutation, MESH: Middle Aged, MESH: European Continental Ancestry Group, Middle Aged, LRRK2, Pedigree, 3. Good health, Female, Adult, MESH: Mutation, Adolescent, MESH: Pedigree, Protein-Serine-Threonine Kinases/genetics, DNA Mutational Analysis/methods, Black People, Protein Serine-Threonine Kinases, Parkinsonian Disorders/diagnosis/genetics, Biology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, White People, MESH: Protein-Serine-Threonine Kinases, 03 medical and health sciences, Parkinsonian Disorders, MESH: Analysis of Variance, MESH: Gene Frequency, medicine, Humans, Gene, Allele frequency, Aged, 030304 developmental biology, MESH: Adolescent, Analysis of Variance, [SDV.GEN]Life Sciences [q-bio]/Genetics, Chi-Square Distribution, MESH: Humans, MESH: Parkinsonian Disorders, African Continental Ancestry Group/genetics, MESH: Adult, medicine.disease, MESH: Male, ddc:616.8, nervous system diseases, MESH: African Continental Ancestry Group, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene have been identified in families with autosomal dominant Parkinson's disease (ADPD), the most common of which is the p.G2019S substitution that has been found at varying frequencies worldwide. Because of the size of the LRRK2 gene, few studies have analysed the entire gene in large series of ADPD families. METHODS: We performed extensive mutation analyses of all 51 coding exons of the LRRK2 gene in index cases from 226 Parkinson's disease families compatible with autosomal dominant inheritance, mostly from France (n = 182) and North Africa (n = 14). RESULTS: We found 79 sequence variants, 29 of which were novel. Eight potentially or proven pathogenic mutations were found in 22 probands (9.7%). There were four novel amino acid substitutions that are potentially pathogenic (p.S52F, p.N363S, p.I810V, p.R1325Q) and two novel variants, p.H1216R and p.T1410M, that are probably not causative. The common p.G2019S mutation was identified in 13 probands (5.8%) including six from North Africa (43%). The known heterozygous p.R1441H and p.I1371V mutations were found in two probands each, and the p.E334K variant was identified in one single patient. Most potentially or proven pathogenic mutations were located in the functional domains of the Lrrk2 protein. CONCLUSION: This study leads us to conclude that LRRK2 mutations are a common cause of autosomal dominant Parkinson's disease in Europe and North Africa.
Published: 2009

10. In Antisynthetase Syndrome, ACPA Are Associated With Severe and Erosive Arthritis: An Overlapping Rheumatoid Arthritis and Antisynthetase Syndrome

Author: Jean Sibilia, Benoit Le Goff, Christophe Deligny, Zahir Amoura, Anne Tournadre, Guillaume Bierry, Sébastien Ottaviani, Alexis Mathian, Pascal Coquerelle, Matthieu Dubois, Eric Hachulla, Guillaume Lefèvre, Laurent Messer, Anne Laure Buchdahl, Géraldine Falgarone, Michel De Bandt, Bernard Geny, Olivier Meyer, René-Marc Flipo, Olivier Benveniste, Baptiste Hervier, Aurélie Duval, Alain Meyer, Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), Centre de référence des maladies autoimmunes et systémiques rares, Service de neuroradiologie [Lille], Hôpital Roger Salengro-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Rhumatologie (HUS), Hôpitaux Universitaires de Strasbourg, Service de Rhumatologie - Hôpital général de Dôle, Service de Rhumatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Service de rhumatologie, CHU Clermont-Ferrand, Service de rhumatologie [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Médecine Interne - Hôpital général de Colmar, Service de Rhumatologie - Hôpital général de Douai, Service de Pneumologie et Réanimation Médicale, Service de néphrologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Unité de Recherche en Epidémiologie Nutritionnelle, UMR1125 INRA/UMR557 INSERM/CNAM, Université Paris 13 (UP13), Centre hospitalier de Béthune, Service de rhumatologie[Lille], Hôpital Roger Salengro-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Référence National pour le Lupus et le Syndrome des Antiphospholipides, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre de référence des maladies rares neuromusculaires, Centre de recherche en myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Néphrologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier de Béthune (CH Béthune), GHT de l'Artois, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Systemic disease, Observational Study, Arthritis, Context (language use), Antisynthetase syndrome, Severity of Illness Index, Article, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Muscle, Skeletal, skin and connective tissue diseases, Lung, Myositis, Autoantibodies, Retrospective Studies, Skin, 030203 arthritis & rheumatology, business.industry, General Medicine, Middle Aged, medicine.disease, Rheumatology, 3. Good health, Radiography, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Case-Control Studies, Rheumatoid arthritis, Immunology, Female, Polyarthritis, business
Abstract: International audience; Abstract: Anticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. The clinical significance of ACPA in patients with antisynthetase syndrome (ASS), a systemic disease characterized by the association of myositis, interstitial lung disease, polyarthralgia, and/or polyarthritis, has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. ACPA-positive ASS patients were first identified among a French multicenter registry of patients with ASS. Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of ASS patients with ACPA. The 17 collected patients were retrospectively studied using a standardized questionnaire and compared with 34 unselected ACPA-negative ASS patients in a case–control study. All ACPA-positive ASS patients suffered from arthritis versus 41% in the control group (P 7-year mean follow-up, extra-articular outcomes and survival were not different. ACPA-positive ASS patients showed an overlapping RA–ASS syndrome, were at high risk of refractory erosive arthritis, and might experience ASS flare when treated with antitumor necrosis factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements.
Published: 2015

11. Partially reversible quadruple sectoranopia caused by vascular steal due to an arteriovenous malformation

Author: C. Arndt, Sabine Defoort-Dhellemmes, Serge Blond, Jean-Yves Gauvrit, Eric Denion, J C Hache, Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de chimie analytique pharmaceutique (LCAP), and University of Geneva [Switzerland]-Ecole de Pharmacie Genève Lausanne (EPGL)
Subjects: Visual acuity, Visual Acuity, Infarction, MESH: Magnetic Resonance Angiography, MESH: Visual Acuity, MESH: Choroid, Magnetic resonance angiography, Angioma, 0302 clinical medicine, MESH: Radiosurgery, MESH: Cerebral Arteries, medicine.diagnostic_test, Geniculate Bodies, Arteriovenous malformation, Anatomy, Sensory Systems, MESH: Perimetry, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, medicine.symptom, MESH: Tomography, X-Ray Computed, Adult, Intracranial Arteriovenous Malformations, MESH: Hemianopsia, Radiosurgery, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Humans, Hemianopsia, MESH: Geniculate Bodies, MESH: Humans, Choroid, business.industry, MESH: Adult, Cerebral Arteries, medicine.disease, Anterior choroidal artery, Ophthalmology, 030221 ophthalmology & optometry, Visual Field Tests, MESH: Visual Fields, Visual Fields, MESH: Intracranial Arteriovenous Malformations, Tomography, X-Ray Computed, business, MESH: Female, Magnetic Resonance Angiography, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Lateral, homonymous upper and lower field blind sectors sparing a horizontal zone define quadruple sectoranopia. This rare campimetric deficit involves ischemia or infarction of parts of the lateral geniculate body supplied by the distal anterior choroidal artery. METHODS: A 41-year-old patient presented with a complaint of blurred vision. Visual acuity was 20/20 on both sides. Visual field showed a left quadruple sectoranopia. CT scan, MRI, MRA and conventional angiography showed a right cerebral arteriovenous malformation supplied partly by the right anterior choroidal artery. Partial retinal nerve fiber layer atrophy matched to the campimetric deficit proved that some degree of infarction involved the lateral geniculate body. RESULTS: The arteriovenous malformation was treated with stereotactic radiosurgery. Two years after treatment, the nidus had completely disappeared. The campimetric deficit began improving from 19 months onwards after stereotactic radiosurgery. Twenty-eight months after treatment, the superior defect had completely reversed. CONCLUSIONS: Quadruple sectoranopia involves ischemia or infarction of parts of the lateral geniculate body supplied by the distal anterior choroidal artery. Following radio-induced angioma thrombosis, blood was no longer shunted away from the right lateral geniculate body, whose viable areas resumed their activity. Accordingly, a partial campimetric recovery occurred.
Published: 2004

12. A two-phase hyperelastic-viscoplastic constitutive model for semi-crystalline polymers: application to polyethylene materials with a variable range of crystal fractions

Author: H. Abdul-Hameed, T. Messager, G. Ayoub, F. Zaïri, M. Naït-Abdelaziz, Z. Qu, Laboratoire de Mécanique de Lille - FRE 3723 (LML), Université de Lille, Sciences et Technologies-Centrale Lille-Centre National de la Recherche Scientifique (CNRS), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Université de Lille, Sciences et Technologies-Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Rotation, Constitutive equation, Semi-crystalline polymers, Biomedical Engineering, Biomaterials, Crystal, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], Composite material, Hyperelastic-viscoplastic, chemistry.chemical_classification, Large deformation, Viscoplasticity, Viscosity, Semi-crystalline polyethylene, Polymer, Polyethylene, Constitutive modelling, Elasticity, Amorphous solid, Atomic Force Microscopy, chemistry, Mechanics of Materials, Hyperelastic material, Deformation (engineering), Crystallization
Abstract: International audience; Polyethylene-based polymers as biomedical materials can contribute to a wide range of biomechanical applications. Therefore, it is important to identify, analyse, and predict with precision their mechanical behaviour. Polyethylene materials are semi-crystalline systems consisting of both amorphous and crystalline phases interacting in a rather complex manner. When the amorphous phase is in the rubbery state, the mechanical behaviour is strongly dependent on the crystal fraction, therefore leading to essentially thermoplastic or elastomeric responses. In this study, the finite deformation stress-strain response of polyethylene materials is modelled by considering these semi-crystalline polymers as two-phase heterogeneous media in order to provide insight into the role of crystalline and amorphous phases on the macro-behaviour and on the material deformation resistances, i.e. intermolecular and network resistances. A hyperelastic-viscoplastic model is developed in contemplation of representing the overall mechanical response of polyethylene materials under large deformation. An evolutionary optimization procedure based on a genetic algorithm is developed to identify the model parameters at different strain rates. The identification results show good agreement with experimental data, demonstrating the usefulness of the proposed approach: the constitutive model, with only one set of identified parameters, allows reproducing the stress-strain behaviour of polyethylene materials exhibiting a wide range of crystallinities, the crystal content becoming the only variable of the model.
Published: 2013

13. Treatment of symptomatic para-articular intraosseous cysts by percutaneous injection of bone cement

Author: B Maurel, Philippe Host, Thomas Le Corroller, Afshin Gangi, Guillaume Bierry, Xavier Buy, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institute for Locomotion, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: musculoskeletal diseases, Adult, Male, medicine.medical_specialty, Percutaneous, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Injections, Intralesional, Radiography, Interventional, 030218 nuclear medicine & medical imaging, Talus, 03 medical and health sciences, 0302 clinical medicine, medicine, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Bone Cysts, Humans, Radiology, Nuclear Medicine and imaging, Tibia, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], 030222 orthopedics, medicine.diagnostic_test, business.industry, Bone Cements, Interventional radiology, Acetabulum, Bone cement, musculoskeletal system, 3. Good health, Surgery, Calcaneus, Treatment Outcome, Fluoroscopy, Orthopedic surgery, Female, Radiology, Cementoplasty, business, Tomography, X-Ray Computed
Abstract: International audience; To describe the technique and clinical outcome of percutaneous injection of bone cement in the treatment of symptomatic para-articular intraosseous cysts. Five patients (three men, two women; mean age 35 years) with painful para-articular intraosseous cysts were treated by percutaneous injection of bone cement under combined fluoroscopic and computed tomography (CT) guidance. The lesions were all located in weight-bearing bones, involving the acetabulum, proximal tibia, distal tibia, talus, and calcaneus, respectively. The average amount of bone cement injected was 2.1 ml (range, 0.6-3.5 ml). Calcium phosphate cement was used in four cases and acrylic cement in one case. There were no immediate or delayed complications. Full pain relief was obtained between 1 and 4 weeks after treatment. All patients made a complete recovery and were pain-free at their last visit. Percutaneous injection of bone cement was a safe and efficient technique in the management of symptomatic para-articular intraosseous cysts in our population.
Published: 2011

14. Sex steroid hormones-related structural plasticity in the human hypothalamus

Author: J.P. Francke, Marc Baroncini, Patrice Jissendi, Didier Dewailly, Sophie Catteau-Jonard, Jean-Pierre Pruvo, Vincent Prevot, Prevot, Vincent, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Service de neurochirurgie, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire d'anatomie, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'endocrinologie, gynécologie et médecine de la reproduction, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille
Subjects: Male, Magnetic Resonance Spectroscopy, Pituitary-Adrenal System, MESH: Magnetic Resonance Imaging, 0302 clinical medicine, MESH: Neuronal Plasticity, Gonadal Steroid Hormones, media_common, MESH: Gonadal Steroid Hormones, 0303 health sciences, Neuronal Plasticity, medicine.diagnostic_test, Magnetic Resonance Imaging, 3. Good health, medicine.anatomical_structure, Neurology, Hypothalamus, MESH: Pituitary-Adrenal System, MESH: Young Adult, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Contraceptives, Oral, Hormonal, Adult, Hypothalamo-Hypophyseal System, medicine.medical_specialty, Cognitive Neuroscience, media_common.quotation_subject, Central nervous system, Thalamus, Biology, MESH: Diffusion Magnetic Resonance Imaging, MESH: Hypothalamo-Hypophyseal System, Contraceptives, Oral, Hormonal, Young Adult, 03 medical and health sciences, Internal medicine, Neuroplasticity, medicine, Humans, Endocrine system, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Menstrual Cycle, Menstrual cycle, 030304 developmental biology, MESH: Humans, MESH: Magnetic Resonance Spectroscopy, Magnetic resonance imaging, MESH: Adult, MESH: Hypothalamus, MESH: Male, Diffusion Magnetic Resonance Imaging, Endocrinology, MESH: Female, 030217 neurology & neurosurgery, Hormone, MESH: Menstrual Cycle
Abstract: International audience; We investigated the effects of an artificial menstrual cycle on brain structure and activity in young women using metabolic magnetic resonance imaging (MRI). We show that the activation of the hypothalamo-pituitary-gonadal axis during the pill-free interval of low-dose combined oral contraceptive use is associated with transient microstructural and metabolic changes in the female hypothalamus but not in the thalamus, a brain structure unrelated to reproductive control, as assessed by water diffusion and proton magnetic resonance spectra measurements. Our results provide neuroanatomical insights into the mechanism by which sex steroid hormones mediate their central effects and raise the intriguing possibility that specific regions of the neuroendocrine brain use ovarian cycle-dependent plasticity to control reproduction in humans. These MRI-based physiological studies may pave the way for the development of new diagnostic and treatment strategies in the central loss of reproductive competence in human syndromes, such as hypothalamic amenorrhea.
Published: 2010

15. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study

Author: Vidailhet, Marie, Yelnik, Jerome, Lagrange, Christelle, Fraix, Valerie, Grabli, David, Thobois, Stephane, Burbaud, Pierre, Welter, Marie-Laure, Xie-Brustolin, Jin, Braga, Maria-Clara Coelho, Ardouin, Claire, Czernecki, Virginie, Klinger, Hélène, Chabardes, Stephan, Seigneuret, Eric, Mertens, Patrick, Cuny, Emmanuel, Navarro, Soledad, Cornu, Philippe, Benabid, Alim-Louis, Le Bas, Jean-Francois, Dormont, Didier, Hermier, Marc, Dujardin, Kathy, Blond, Serge, Krystkowiak, Pierre, Destée, Alain, Bardinet, Eric, Agid, Yves, Krack, Paul, Broussolle, Emmanuel, Pollak, Pierre, Renseigné, Non, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CIC AP-HP (pitie-Salpetriere)/inserm, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), UM des troubles du mouvement, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie, Service de Neurochirurgie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Physiologie et physiopathologie de la signalisation cellulaire (PPSC), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-CHU Bordeaux [Bordeaux]-Centre National de la Recherche Scientifique (CNRS), Département de Neurologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-IFR70-CHU Pitié-Salpêtrière [APHP], Service de neurologie, Hospices Civils de Lyon (HCL)-Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Centre De Référence National 'Syndrome Gilles de la Tourette', Pôle des Maladies du Système Nerveux [CHU Pitié-Salpêtrière], Service de neurologie C [Hôpital Pierre Wertheimer - HCL], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université de Lyon, Département de neurochirurgie, Service de Neurochirurgie [Hopital Pierre Wertheimer - HCL], Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), RMN biomédicale : de la cellule à l'homme (RBCH), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-DIR CENTRALE DU SSA-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de neuro-radiologie [CHU Pitié-Salpêtrière], Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de neuroradiologie, Neurology, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc - U837 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université Lille 2 - Faculté de Médecine, Service de neurologie [Amiens], CHU Amiens-Picardie, Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Neuro-Imagerie de Recherche (CENIR), Fédération des Maladies du Système Nerveux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de neuroradiologie [Lyon], Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Fédération de neurologie 4, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-CHU Bordeaux [Bordeaux]-Centre National de la Recherche Scientifique (CNRS), Département de neurologie [Lille], Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), PHRC National - Cerebral Palsy Foundation - Fondation Motrice/APETREIMC- INSERM - Dystonia national Network - Medtronic, Issartel, Jean-Paul, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (ISC-MJ), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, MESH: Globus Pallidus, MESH: Dystonia, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Choreoathetosis, Pilot Projects, Athetosis/complications/*therapy, Severity of Illness Index, Functional Laterality, Magnetic Resonance Imaging/methods, MESH: Magnetic Resonance Imaging, MESH: Basal Ganglia, Disability Evaluation, MESH: Athetosis, Dystonia/complications/*therapy, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Cerebral Palsy/complications/*therapy, Basal ganglia, Prospective Studies, Basal Ganglia/pathology, Dystonia, 0303 health sciences, MESH: Statistics, Nonparametric, Chorea/complications/*therapy, MESH: Disability Evaluation, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], 3. Good health, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], MESH: Young Adult, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Psychology, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Adult, Deep Brain Stimulation/*methods, medicine.medical_specialty, Deep brain stimulation, MESH: Cerebral Palsy, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Statistics, Nonparametric, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Cerebral palsy, Young Adult, 03 medical and health sciences, Physical medicine and rehabilitation, MESH: Severity of Illness Index, Severity of illness, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Spasticity, MESH: Functional Laterality, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurostimulation, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, 030304 developmental biology, Globus Pallidus/*physiology, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], MESH: Chorea, MESH: Humans, MESH: Adult, medicine.disease, MESH: Pilot Projects, MESH: Male, MESH: Prospective Studies, ddc:616.8, nervous system diseases, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Physical therapy, Neurology (clinical), MESH: Deep Brain Stimulation, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Cerebral palsy (CP) with dystonia-choreoathetosis is a common cause of disability in children and in adults, and responds poorly to medical treatment. Bilateral pallidal deep brain stimulation (BP-DBS) of the globus pallidus internus (GPi) is an effective treatment for primary dystonia, but the effect of this reversible surgical procedure on dystonia-choreoathetosis CP, which is a subtype of secondary dystonia, is unknown. Our aim was to test the effectiveness of BP-DBS in adults with dystonia-choreoathetosis CP. METHODS: We did a multicentre prospective pilot study of BP-DBS in 13 adults with dystonia-choreoathetosis CP who had no cognitive impairment, little spasticity, and only slight abnormalities of the basal ganglia on MRI. The primary endpoint was change in the severity of dystonia-choreoathetosis after 1 year of neurostimulation, as assessed with the Burke-Fahn-Marsden dystonia rating scale. The accuracy of surgical targeting to the GPi was assessed masked to the results of neurostimulation. Analysis was by intention to treat. FINDINGS: The mean Burke-Fahn-Marsden dystonia rating scale movement score improved from 44.2 (SD 21.1) before surgery to 34.7 (21.9) at 1 year post-operatively (p=0.009; mean improvement 24.4 [21.1]%, 95% CI 11.6-37.1). Functional disability, pain, and mental health-related quality of life were significantly improved. There was no worsening of cognition or mood. Adverse events were related to stimulation (arrest of the stimulator in one patient, and an adjustment to the current intensity in four patients). The optimum therapeutic target was the posterolateroventral region of the GPi. Little improvement was seen when the neurostimulation diffused to adjacent structures (mainly to the globus pallidus externus [GPe]). INTERPRETATION: Bilateral pallidal neurostimulation could be an effective treatment option for patients with dystonia-choreoathetosis CP. However, given the heterogeneity of motor outcomes and the small sample size, results should be interpreted with caution. The optimum placement of the leads seemed to be a crucial, but not exclusive, factor that could affect a good outcome. FUNDING: National PHRC; Cerebral Palsy Foundation: Fondation Motrice/APETREIMC; French INSERM Dystonia National Network; Medtronic.
Published: 2009

16. Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms

Author: Pablo, Ibáñez, Suzanne, Lesage, Sabine, Janin, Ebba, Lohmann, Frank, Durif, Alain, Destée, Anne-Marie, Bonnet, Christine, Brefel-Courbon, Simon, Heath, Diana, Zelenika, Yves, Agid, Alexandra, Dürr, Alexis, Brice, Marie, Vidailhet, Neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'investigation clinique de Toulouse (CIC 1436), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Ministère Français de la Recherche and de la technologie Verum Foundation Contrat de l'Union Européenne LSHM-CT-2003-503330/APOPIS de la Commission Européenne Association France Parkinson, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Pollak, Pierre, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], and Savasta, Marc
Subjects: Male, DNA Mutational Analysis, Gene Dosage, MESH: DNA Repeat Expansion, MESH: Gene Dosage, Genes, Dominant/genetics, Parkinsonian Disorders/genetics/metabolism/physiopathology, MESH: Genotype, Exon, 0302 clinical medicine, MESH: Aged, 80 and over, Genotype, MESH: Brain Chemistry, MESH: DNA Mutational Analysis, Genes, Dominant, Oligonucleotide Array Sequence Analysis, Genetics, Aged, 80 and over, MESH: Aged, 0303 health sciences, DNA Repeat Expansion, MESH: Middle Aged, MESH: Genetic Testing, Parkinsonism, Genetic Predisposition to Disease/genetics, MESH: Polymorphism, Single Nucleotide, MESH: Genetic Predisposition to Disease, Chromosome Breakage, Middle Aged, Polymorphism, Single Nucleotide/genetics, Phenotype, 3. Good health, MESH: Chromosome Breakage, alpha-Synuclein, Female, Brain Chemistry/genetics, Adult, Haplotypes/genetics, Microsatellite Repeats/genetics, Biology, Polymorphism, Single Nucleotide, Alpha-Synuclein/genetics, 03 medical and health sciences, DNA Repeat Expansion/genetics, Arts and Humanities (miscellaneous), Parkinsonian Disorders, MESH: alpha-Synuclein, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Genotyping, 030304 developmental biology, Aged, Brain Chemistry, MESH: Humans, MESH: Parkinsonian Disorders, Haplotype, MESH: Adult, Gene rearrangement, MESH: Haplotypes, Gene Dosage/genetics, medicine.disease, MESH: Male, nervous system diseases, ddc:616.8, Haplotypes, Genetic marker, MESH: Oligonucleotide Array Sequence Analysis, Neurology (clinical), MESH: Microsatellite Repeats, MESH: Genes, Dominant, MESH: Female, 030217 neurology & neurosurgery, Microsatellite Repeats
Abstract: International audience; OBJECTIVE: Genomic multiplications of the alpha-synuclein gene (SNCA) cause autosomal dominant Parkinson disease (ADPD). The aim of this study was to assess the frequency and phenotype of SNCA rearrangements in a large series of families with typical or atypical AD parkinsonism. DESIGN: Patients were screened by the exon dosage of the SNCA gene. The genotype of patients and relatives carrying SNCA rearrangements, the size of the multiplied regions, and the centromeric and telomeric breakpoints were determined by microsatellite dosage and 250K Affymetrix Single Polymorphism Nucleotide microarrays (Affymetrix, Santa Clara, California). SUBJECTS: Index cases and, whenever appropriate, relatives of 286 mainly European families with ADPD were screened. RESULTS: Four of 264 families (1.5%) with typical ADPD carried duplications and 1 of 22 families (4.5%) with atypical AD parkinsonism carried a triplication of SNCA. Genotyping and dosage analyses showed that the multiplied regions were variable in size (0.42-5.29 megabase pairs), suggesting that SNCA multiplications occurred independently. Phenotype analyses showed that the severity of the disease correlated with the SNCA copy number, but not with the minimal number of multiplied genes (1 to 33). Haplotype analysis of polymorphic markers suggested that multiplication of the SNCA gene occurred by both interchromosomal and intrachromosomal rearrangement. CONCLUSIONS: Our results suggest that SNCA rearrangements may be more frequent than point mutations in ADPD. Furthermore, our results indicate that the phenotype associated with SNCA multiplications correlates with the number of copies of the gene and provides the first insight into the mechanisms underlying SNCA multiplication.
Published: 2009

17. Acute deep-brain stimulation of the internal and external globus pallidus in primary dystonia: functional mapping of the pallidum

Author: Jean-François Le Bas, Pierre Krystkowiak, Eric Bardinet, Pierre Pollak, Alain Destée, Didier Dormont, Jean-Luc Houeto, Christelle Lagrange, Jérôme Yelnik, Sophie Tezenas du Moncel, Marie Vidailhet, Jean-Pierre Pruvo, Laurent Vercueil, Yves Agid, Valérie Mesnage, Service de neurologie [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Neurosciences cognitives et imagerie cérébrale (NCIC), Centre National de la Recherche Scientifique (CNRS), Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CIC AP-HP (pitie-Salpetriere)/inserm, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Michallon, CHU Grenoble, Service de neuro-radiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service de neuroradiologie [Lille], Unité de Recherche Clinique, Département de neurologie, Service de neurologie 1 [CHU Pitié-Salpétrière], Collaboration, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Deransart, Colin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: Male, MESH: Globus Pallidus, MESH: Dystonia, Deep Brain Stimulation, medicine.medical_treatment, MESH: Muscle Contraction, Stimulation, Neurological disorder, 0302 clinical medicine, Basal ganglia, MESH: Double-Blind Method, Prospective Studies, Abnormal posturing, MESH: Treatment Outcome, Dystonia, 0303 health sciences, MESH: Muscle, Skeletal, MESH: Middle Aged, MESH: Electric Stimulation, Middle Aged, Treatment Outcome, Globus pallidus, Anesthesia, Female, Muscle Contraction, Adult, Deep brain stimulation, Adolescent, Globus Pallidus, Central nervous system disease, 03 medical and health sciences, Double-Blind Method, Arts and Humanities (miscellaneous), [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Muscle, Skeletal, 030304 developmental biology, MESH: Adolescent, MESH: Humans, business.industry, MESH: Adult, medicine.disease, Electric Stimulation, MESH: Male, MESH: Prospective Studies, Neurology (clinical), MESH: Deep Brain Stimulation, business, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: Dystonia is a syndrome characterized by prolonged muscle contractions that cause sustained twisting movements and abnormal posturing of body parts. Patients with the severe and generalized forms can benefit from bilateral high-frequency pallidal stimulation. OBJECTIVE: To investigate the functional map of the globus pallidus (GP) in patients with primary generalized dystonia. DESIGN: Prospective multicenter, double-blind, video-controlled study in patients treated at a university hospital. SETTING: University secondary care centers. PATIENTS: Twenty-two patients with primary generalized dystonia. INTERVENTIONS: Acute internal and external pallidal deep-brain stimulation or pallidal deep-brain stimulation. MAIN OUTCOME MEASURES: The clinical effects of acute bilateral high-frequency ventral vs acute dorsal pallidal stimulation were assessed with the Movement subscale of the Burke-Fahn-Marsden Dystonia Rating Scale. Intrapallidal localization of the contacts of the quadripolar electrodes was performed using a 3-dimensional atlas-magnetic resonance imaging coregistration method by investigators blinded to the clinical outcome. RESULTS: Bilateral acute ventral stimulation of the GP significantly improved the Burke-Fahn-Marsden Dystonia Rating Scale score by 42% and resulted in stimulation of contacts located in the internal GP or medullary lamina in 18 of 21 patients. Bilateral acute dorsal pallidal stimulation, primarily localized within the external GP, had variable effects across patients, with half demonstrating slight or no improvement or even aggravation of dystonia compared with baseline. CONCLUSIONS: Ventral pallidal stimulation, primarily of the internal GP or medullary lamina or both, is the optimal method for the treatment of dystonia. The varying effects across patients of bilateral acute dorsal pallidal stimulation, primarily of the external GP, suggest that unknown factors associated with dystonia could have a role in and contribute to the effects of the electrical stimulation.
Published: 2007

18. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis

Author: Philippe Piquet, Jean-François Albucher, Pascal Favrole, Jean-François Bonneville, Abstr Act, Thierry Moulin, Michel Lievre, Didier Leys, Jacques Watelet, Jean-Pierre Pruvo, Xavier Ducrocq, Maurice Giroud, Alain Viguier, Fausto Viader, Gilles Chatellier, Bernard Beyssen, Vincent Larrue, Jean-Philippe Neau, Hassan Hosseini, Jean-Christophe Pillet, Alain Branchereau, S Investigators, Jean-Louis Mas, Emmanuel Touzé, Pierre Garnier, Jean-Pierre Becquemin, Service de Pédiatrie, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet, Laboratoire de Santé Publique et Informatique Médicale (SPIM), Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Vasculaire, Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Thérapeutiques substitutives du coeur et des vaisseaux (TSCV), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Neurologie Vasculaire [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Swedish Institute of Space Physics [Uppsala] (IRF), Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie, Hôpital Sainte-Anne, Migrations Internationales, Territorialités, Identités (MITI), Université de Poitiers-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Nice-Hôpital l'Archet, Laboratoire de Santé Publique et Informatique Médicale ( SPIM ), Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital de la Timone [CHU - APHM] ( TIMONE ), Laboratoire d'Astrophysique de Grenoble ( LAOG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Thérapeutiques substitutives du coeur et des vaisseaux ( TSCV ), Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Laboratoire de Biométrie et Biologie Evolutive ( LBBE ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique ( Inria ) -Centre National de la Recherche Scientifique ( CNRS ), Science et Ingénierie des Matériaux et Procédés ( SIMaP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Hôpital Roger Salengro-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Hôpital Sainte-Marguerite [CHU - APHM] ( Hôpitaux Sud ), Swedish Institute of Space Physics [Uppsala] ( IRF ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -École pratique des hautes études ( EPHE ) -Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Migrations Internationales, Territorialités, Identités ( MITI ), Université Bordeaux Montaigne-Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université de Poitiers-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Bordeaux Montaigne-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Institut de médecine moléculaire de Rangueil ( I2MR ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Fédérale Toulouse Midi-Pyrénées, Service de chirurgie cadiovasculaire et thoracique [Rouen], CHU Rouen-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie ( UNIROUEN ), Centre de Recherches sur la Cognition et l'Apprentissage ( CeRCA ), and Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Male, MESH : Stroke, medicine.medical_treatment, MESH : Risk, MESH : Aged, Myocardial Infarction, 030204 cardiovascular system & hematology, MESH: Endarterectomy, Carotid, 0302 clinical medicine, MESH: Carotid Stenosis, MESH : Female, Carotid Stenosis, MESH: Incidence, Stroke, MESH : Stents, Endarterectomy, MESH: Treatment Outcome, MESH: Aged, Endarterectomy, Carotid, MESH: Risk, Incidence, MESH : Endarterectomy, Carotid, General Medicine, MESH: Follow-Up Studies, MESH : Incidence, 3. Good health, MESH: Myocardial Infarction, Treatment Outcome, Female, Stents, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Risk, medicine.medical_specialty, MESH : Male, MESH : Treatment Outcome, MESH: Stroke, 03 medical and health sciences, Angioplasty, medicine, Humans, MESH : Angioplasty, cardiovascular diseases, MESH : Carotid Stenosis, Aged, MESH: Angioplasty, MESH: Humans, Vascular disease, business.industry, MESH : Humans, Stent, [ SDV.SP.PHARMA ] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH : Follow-Up Studies, medicine.disease, MESH: Male, Surgery, Stenosis, MESH: Stents, Relative risk, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Carotid stenting, MESH : Myocardial Infarction, business, MESH: Female, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: International audience; BACKGROUND: Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis. METHODS: We conducted a multicenter, randomized, noninferiority trial to compare stenting with endarterectomy in patients with a symptomatic carotid stenosis of at least 60%. The primary end point was the incidence of any stroke or death within 30 days after treatment. RESULTS: The trial was stopped prematurely after the inclusion of 527 patients for reasons of both safety and futility. The 30-day incidence of any stroke or death was 3.9% after endarterectomy (95% confidence interval [CI], 2.0 to 7.2) and 9.6% after stenting (95% CI, 6.4 to 14.0); the relative risk of any stroke or death after stenting as compared with endarterectomy was 2.5 (95% CI, 1.2 to 5.1). The 30-day incidence of disabling stroke or death was 1.5% after endarterectomy (95% CI, 0.5 to 4.2) and 3.4% after stenting (95% CI, 1.7 to 6.7); the relative risk was 2.2 (95% CI, 0.7 to 7.2). At 6 months, the incidence of any stroke or death was 6.1% after endarterectomy and 11.7% after stenting (P=0.02). There were more major local complications after stenting and more systemic complications (mainly pulmonary) after endarterectomy, but the differences were not significant. Cranial-nerve injury was more common after endarterectomy than after stenting. CONCLUSIONS: In this study of patients with symptomatic carotid stenosis of 60% or more, the rates of death and stroke at 1 and 6 months were lower with endarterectomy than with stenting. (ClinicalTrials.gov number, NCT00190398 [ClinicalTrials.gov].).
Published: 2006

19. Utility of the Mattis dementia rating scale to assess the efficacy of rivastigmine in dementia associated with Parkinson's disease

Author: Jacques Touchon, Kathy Dujardin, Lucette Lacomblez, David Devos, Jean-Jacques Pere, Stéphane Duhem, Franck Durif, Alain Destée, Rose-Marie Marié, Pierre Pollak, Savasta, Marc, Noyaux gris centraux, Université de Lille, Sciences et Technologies-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neurochirurgie générale et stéréotaxique fonctionnelle, Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Fédération des Maladies du Système Nerveux, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pathologies du système nerveux : recherche épidémiologique et clinique, Université Montpellier 1 (UM1)-IFR76-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Recherche clinique, Novartis, Collaboration, CHU Estaing [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand]
Subjects: Male, medicine.medical_specialty, MESH: Psychiatric Status Rating Scales, Neurology, Parkinson's disease, Phenylcarbamates, Rivastigmine, Neuropsychological Tests, Placebo, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, MESH: Phenylcarbamates, Internal medicine, medicine, Dementia, Humans, MESH: Double-Blind Method, 030212 general & internal medicine, Psychiatry, Aged, Psychiatric Status Rating Scales, MESH: Aged, MESH: Humans, Cognitive disorder, Parkinson Disease, MESH: Neuropsychological Tests, MESH: Neuroprotective Agents, medicine.disease, MESH: Dementia, MESH: Male, Neuroprotective Agents, Severe dementia, Female, Neurology (clinical), Psychology, MESH: Female, 030217 neurology & neurosurgery, MESH: Parkinson Disease, medicine.drug, Executive dysfunction
Abstract: International audience; INTRODUCTION: The severe, cortical, cholinergic depletion accompanying Parkinson's disease (PD) is considered as a highly probable correlate of cognitive and behavioural dysfunction. Recent studies have demonstrated that cholinesterase inhibitors (notably rivastigmine) are beneficial in patients suffering from dementia associated with PD (PDD). However, the primary efficacy variables used in such work came from scales designed for Alzheimer's disease (AD), even though the cognitive symptoms in PD and AD dementia do not overlap completely. The aim of the present study (a double-blind, placebo-controlled clinical trial) was to determine the utility of the Mattis dementia rating scale - the most commonly used scale in PD patients - to assess the efficacy of a 24-week rivastigmine treatment. METHODS: Twenty-eight patients with PD, who constituted a subgroup of patients enrolled to the EXPRESS study (Emre et al, N Engl J Med 2004) participated in this study. They suffered from mild to moderately severe dementia (MMSE scores above 10 and below 24), with an onset of cognitive symptoms occurring at least two years after the diagnosis of PD. Patients were randomly assigned to treatment with rivastigmine (3 to 12 mg per day) or placebo. The Mattis dementia rating scale was administered to patients from six centres in France at the baseline and end-point visits. RESULTS: Compared with placebo, a 24-week rivastigmine treatment led to a significant improvement in the overall score on the Mattis dementia rating scale (p = 0.031), with a trend towards a significant improvement in the "Attention" subscale score (p = 0.061). Correlation analysis showed that in the rivastigmine group, performance on the Mattis "Attention" and "Initiation" subscales appeared to contribute heavily to the improvement in the overall score. Moreover, the latter was also related to an improvement in activities of daily living and a reduction in behavioural disturbances. DISCUSSION: By using the Mattis dementia rating scale (which comprises items that are sensitive to executive dysfunction), the present study confirmed that rivastigmine has a beneficial effect on cognitive function in PDD. Despite our study's small sample size, the Mattis scale was able to detect this improvement and could thus be considered as an interesting outcome measure in further work.
Published: 2006

20. Intrinsic 2D/3D registration based on a hybrid approach: use in the radiosurgical imaging process

Author: Vermandel, Maximilien, Betrouni, Nacim, Gauvrit, Jean-Yves, Pasquier, David, Vasseur, Christrian, Rousseau, Jean, Therapies Interventionnelles Assistees Par l'Image et la Simulation - U 703 (Thiais), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Biophysique, Médecine Nucléaire et Technologies Médicales, UPRES EA1049-Université de Lille, Droit et Santé, Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de radiothérapie / curiethérapie, Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER, Vermandel, Maximilien, Therapies Interventionnelles Assistees Par l'Image et la Simulation, and Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER
Subjects: [SDV.IB] Life Sciences [q-bio]/Bioengineering, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Reproducibility of Results, Radiosurgery, Arteriovenous Malformations, Image Processing, Computer-Assisted, Humans, Radiographic Image Interpretation, Computer-Assisted, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Algorithms, Magnetic Resonance Angiography, Mathematics
Abstract: During the latest years, numerous methods of multimodal image matching have been developed. Associated with medical imaging, these developments make it possible to match images using intrinsic data, as anatomical data, instead of external referential, as stereotactic frames. Thus, the use of intrinsic registration considerably increases possibilities in medical image analysis. Unfortunately, these techniques mostly remain in the research field and are rarely used in clinical daily practice. In this paper, we present a method for matching projective imaging (2D, radiography, angiography...) and tomographic imaging (3D, Magnetic Resonance Imaging, Computed Tomography). Furthermore, we propose a radiosurgical application for Arteriovenous Malformation (AVM). Radiosurgery planning for the treatment of AVM requires multiple image acquisitions in multimodality to define the irradiation target and to compute the dosimetry. All the planning images are acquired with a stereotactic frame. We describe in this paper the image registration technique that we propose to include diagnostic images in the planning process and the different steps required to validate our approach. In the current state, the results obtained do not enable us to replace the conventional technique due to the accuracy expected, but the analysis of the results shows that improvements of the protocol would make this application finally operational.
Published: 2006

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20 results on '"Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)"'

1. Gender issues from the perspective of health-care professionals in Neuro-oncology: an EANO and EORTC Brain Tumor Group survey

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7. Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli

8. MRI atlas of the human hypothalamus

9. Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease

10. In Antisynthetase Syndrome, ACPA Are Associated With Severe and Erosive Arthritis: An Overlapping Rheumatoid Arthritis and Antisynthetase Syndrome

11. Partially reversible quadruple sectoranopia caused by vascular steal due to an arteriovenous malformation

12. A two-phase hyperelastic-viscoplastic constitutive model for semi-crystalline polymers: application to polyethylene materials with a variable range of crystal fractions

13. Treatment of symptomatic para-articular intraosseous cysts by percutaneous injection of bone cement

14. Sex steroid hormones-related structural plasticity in the human hypothalamus

15. Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study

16. Alpha-synuclein gene rearrangements in dominantly inherited parkinsonism: frequency, phenotype, and mechanisms

17. Acute deep-brain stimulation of the internal and external globus pallidus in primary dystonia: functional mapping of the pallidum

18. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis

19. Utility of the Mattis dementia rating scale to assess the efficacy of rivastigmine in dementia associated with Parkinson's disease

20. Intrinsic 2D/3D registration based on a hybrid approach: use in the radiosurgical imaging process

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