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2. Beating the empty pelvis syndrome: the PelvEx Collaborative core outcome set study protocol

Author

G Palmer, T Smith, A Ghosh, K Brown, C Harris, B Griffiths, H Kim, A Martinez, J Park, S Kumar, D Collins, M Ito, M Davies, A Wolthuis, A Lyons, J Rintala, M Quinn, K Boyle, T Skeie-Jensen, S Domingo, A Gil-Moreno, M Wilson, V Lago, F Köse, A Saklani, KKL Chan, G Vizzielli, PJ Nilsson, B Flor, H Yano, A Antoniou, M Valente, M Angeles, B Eyjolfsdottir, P Chong, V George, A Simpson, D Proud, J Wild, A Oliver, C Taylor, E Burns, C Rao, RJ Davies, P Georgiou, M Brunner, D Taylor, K Weber, C Mann, HJ Kim, S Rasheed, A Denys, M Bedford, J Tiernan, G Turner, D Steffens, E Egger, A Burgess, P Tejedor, B Nguyen, B Yip, M Fahy, W Hohenberger, T Glover, R Thurairaja, W Ceelen, S Laurberg, L Castro, O Aziz, M Gargiulo, Y Tsukada, A Sahai, S Warrier, T Glyn, M Rochester, B Lampe, R Sayyed, M Duff, D Burling, G Poggioli, T Akiyoshi, C Deutsch, A Renehan, IR Daniels, NJ Smart, JT Jenkins, ST O’Dwyer, O Peacock, R Kiran, NS Fearnhead, PA Sutton, D Patsouras, ML George, FD Mcdermott, DC Winter, J Beynon, R Hompes, NA Stylianides, N Rajendran, AG Heriot, DA Harris, JMD Wheeler, C Selvasekar, M Kaufman, J Armitage, S Kapur, E Hyun, F Fleming, N Campain, K Uehara, M Kraft, MS Khan, M Albert, D Shida, J Yip, JJ Smith, S Baransi, C Bergzoll, G Pellino, I Shaikh, JS McGrath, C Cotsoglou, JHW de Wilt, Y Kanemitsu, M Shaban, CT West, MA West, I Drami, C Behrenbruch, G Guerra, PS Waters, N Woodward, S Applin, SJ Charles, SA Rose, E Pape, GH van Ramshorst, AH Mirnezami, AGJ Aalbers, N Abdul Aziz, N Abecasis, M Abraham-Nordling, R Alahmadi, W Alberda, M Andric, E Angenete, R Auer, KK Austin, E Aytac, N Bacalbasa, RP Baker, M Bali, G Baseckas, B Bebington, BK Bednarski, GL Beets, PL Berg, S Biondo, L Bordeianou, E Brecelj, AB Bremers, P Buchwald, A Bui, JWA Burger, S Carvalhal, A Caycedo-Marulanda, GJ Chang, MH Chew, AK Chok, HK Christensen, H Clouston, AJ Colquhoun, J Constantinides, A Corr, M Coscia, M Cosimelli, PE Coyne, RS Croner, L Damjanovic, CP Delaney, QD Denost, D Dietz, EJ Dozois, E Drozdov, T Eglinton, JM Enrique-Navascues, E Espín-Basany, MD Evans, S Fichtner-Feigl, K Flatmark, J Folkesson, K Foskett, FA Frizelle, J Funder, MA Gallego, E García-Granero, JL García-Sabrido, VG Gava, L Gentilini, L Ghouti, F Giner, N Ginther, P Goffredo, T Golda, CM Gomez, F Gwenaël, JAW Hagemans, V Hanchanale, DP Harji, C Helbren, RM Helewa, G Hellawell, D Hochman, T Holm, A Holmström, B Hornung, S Hurton, LH Iversen, K Jourand, S Kaffenberger, GV Kandaswamy, M Kazi, SR Kelley, DS Keller, ME Kelly, S Kersting, SHJ Ketelaers, J Khaw, CE Koh, Kok NFM, R Kokelaar, C Kontovounisios, M Koutra, Kristensen HØ, M Kusters, Z Lakkis, MC Langheinrich, T Larach, SG Larsen, DW Larson, WL Law, PJ Lee, M Limbert, A Loria, ML Lydrup, AC Lynch, M Mackintosh, C Mantyh, KL Mathis, CFS Margues, A Martling, Meijerink WJHJ, A Merchea, S Merkel, AM Mehta, DR McArthur, JJ McCormick, A McPhee, J Maciel, S Malde, S Manfredelli, S Mikalauskas, D Modest, JRT Monson, JR Morton, TG Mullaney, AS Navarro, H Neeff, I Negoi, JWM Neto, MB Nielsen, GAP Nieuwenhuijzen, S Nordkamp, K Paarnio, E Pappou, AC Peterson, F Pfeffer, F Piqeur, J Pinson, A Quyn, RW Radwan, PC Rasmussen, E Rausa, SE Regenbogen, HM Reims, R Rocha, J Rohila, J Rothbarth, M Rottoli, C Roxburgh, HJT Rutten, B Safar, PM Sagar, T Sammour, AMP Schizas, E Schwarzkopf, D Scripcariu, V Scripcariu, G Seifert, P Smart, AM Solbakken, MJ Solomon, MM Sørensen, M Spasojevic, SR Steele, K Stitzenberg, L Stocchi, T Swartling, H Sumrien, T Swartking, H Takala, EJ Tan, A Tekin, PP Tekkis, J Teras, MR Thanapal, HV Thaysen, E Thorgersen, EL Toh, P Tsarkov, J Tolenaar, S Tsukamoto, JJ Tuech, WH Turner, JB Tuynman, J van Rees, D van Zoggel, W Vásquez-Jiménez, C Verhoef, M Vierimaa, ELK Voogt, C Wakeman, HH Wasmuth, MR Weiser, OL Westney, RN Yoo, MA Zappa, and L Sorrentino

Subjects
Medicine
Abstract

Introduction The empty pelvis syndrome is a significant source of morbidity following pelvic exenteration surgery. It remains poorly defined with research in this field being heterogeneous and of low quality. Furthermore, there has been minimal engagement with patient representatives following pelvic exenteration with respect to the empty pelvic syndrome. ‘PelvEx—Beating the empty pelvis syndrome’ aims to engage both patient representatives and healthcare professionals to achieve an international consensus on a core outcome set, pathophysiology and mitigation of the empty pelvis syndrome.Methods and analysis A modified-Delphi approach will be followed with a three-stage study design. First, statements will be longlisted using a recent systematic review, healthcare professional event, patient and public engagement, and Delphi piloting. Second, statements will be shortlisted using up to three rounds of online modified Delphi. Third, statements will be confirmed and instruments for measurable statements selected using a virtual patient-representative consensus meeting, and finally a face-to-face healthcare professional consensus meeting.Ethics and dissemination The University of Southampton Faculty of Medicine ethics committee has approved this protocol, which is registered as a study with the Core Outcome Measures in Effectiveness Trials Initiative. Publication of this study will increase the potential for comparative research to further understanding and prevent the empty pelvis syndrome.Trial registration number NCT05683795.

Published
2024
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3. Particle size distributions inside and around the artificial crater produced by the Hayabusa2 impact experiment on Ryugu

Author

K. Ogawa, N. Sakatani, T. Kadono, M. Arakawa, R. Honda, K. Wada, K. Shirai, Y. Shimaki, K. Ishibashi, Y. Yokota, T. Saiki, H. Imamura, Y. Tsuda, S. Nakazawa, Y. Takagi, M. Hayakawa, H. Yano, C. Okamoto, Y. Iijima, T. Morota, S. Kameda, E. Tatsumi, Y. Cho, K. Yoshioka, H. Sawada, M. Matsuoka, M. Yamada, T. Kouyama, H. Suzuki, C. Honda, and S. Sugita

Subjects
Asteroid Ryugu, SCI crater, Particle size distribution, Ejecta deposition, Geography. Anthropology. Recreation, Geodesy, QB275-343, Geology, QE1-996.5
Abstract

Abstract Japanese Hayabusa2 spacecraft has successfully carried out an impact experiment using a small carry-on impactor (SCI) on an asteroid (162173) Ryugu. We examine the size distribution of particles inside and outside an artificial impact crater (the SCI crater) based on the images taken by the optical navigation camera onboard the Hayabusa2 spacecraft. The circumferential variation in particle size distribution inside the SCI crater is recognized and we interpret that major circumferential variation is caused by the large boulders inside the SCI crater that existed prior to the impact. The size distribution inside the SCI crater also shows that the subsurface layer beneath the SCI impact site had a large number of particles with a characteristic size of – 9 cm, which is consistent with the previous evaluations. On the other hand, the size distribution outside the SCI crater exhibits the radial variation, implying that the deposition of ejecta from the SCI crater is involved. The slope of the size distribution outside the crater at small sizes differs from the slope of the size distribution on the surface of Ryugu by approximately 1 or slightly less. This is consistent with the claim that some particles are buried in fine particles of the subsurface origin included in ejecta from the SCI crater. Thus, the particle size distributions inside and outside the SCI crater reveal that the subsurface layer beneath the SCI impact site is rich in fine particles with – 9 cm in size while the particles on the surface have a size distribution of a power-law form with shallower slopes at small sizes due to the deposition of fine ejecta from the subsurface layer. Finally, we discuss a process responsible for this difference in particle size distribution between the surface and the subsurface layers. The occurrence of segregation in the gravitational flow of particles on the surface of Ryugu is plausible. Graphical Abstract

Published
2022
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5. The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential

Author

N. Kfoury-Beaumont, R. Prakasam, S. Pondugula, J. S. Lagas, S. Matkovich, P. Gontarz, L. Yang, H. Yano, A. H. Kim, J. B. Rubin, and K. L. Kroll

Subjects
DIPG, H3K27M, Epigenetics, Aberrant differentiation, Pediatric brain tumors, Biology (General), QH301-705.5
Abstract

Abstract Background Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis. For example, lysine 27 to methionine mutation (H3K27M) in the H3F3A gene occurs frequently in Diffuse Intrinsic Pontine Gliomas (DIPGs), the most aggressive pediatric glioma. As H3K27M mutation is necessary but insufficient to cause DIPGs, it is accompanied by additional mutations in tumors. However, how H3K27M alone increases vulnerability to DIPG tumorigenesis remains unclear. Results Here, we used human embryonic stem cell models with this mutation, in the absence of other DIPG contributory mutations, to investigate how H3K27M alters cellular proliferation and differentiation. We found that H3K27M increased stem cell proliferation and stem cell properties. It interfered with differentiation, promoting anomalous mesodermal and ectodermal gene expression during both multi-lineage and germ layer-specific cell specification, and blocking normal differentiation into neuroectoderm. H3K27M mutant clones exhibited transcriptomic diversity relative to the more homogeneous wildtype population, suggesting reduced fidelity of gene regulation, with aberrant expression of genes involved in stem cell regulation, differentiation, and tumorigenesis. These phenomena were associated with global loss of H3K27me3 and concordant loss of DNA methylation at specific genes in H3K27M-expressing cells. Conclusions Together, these data suggest that H3K27M mutation disrupts normal differentiation, maintaining a partially differentiated state with elevated clonogenicity during early development. This disrupted response to early developmental cues could promote tissue properties that enable acquisition of additional mutations that cooperate with H3K27M mutation in genesis of DMG/DIPG. Therefore, this work demonstrates for the first time that H3K27M mutation confers vulnerability to gliomagenesis through persistent clonogenicity and aberrant differentiation and defines associated alterations of histone and DNA methylation.

Published
2022
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6. Resolving Diverse Oxygen Transport Pathways Across Sr‐Doped Lanthanum Ferrite and Metal‐Perovskite Heterostructures

Author

Sandra D. Taylor, Kayla H. Yano, Michel Sassi, Bethany E. Matthews, Elizabeth J. Kautz, Sten V. Lambeets, Sydney Neuman, Daniel K. Schreiber, Le Wang, Yingge Du, and Steven R. Spurgeon

Subjects
atom exchange, atom probe tomography, density functional theory, oxygen diffusion, perovskites, Physics, QC1-999, Technology
Abstract

Abstract Perovskite structured transition metal oxides are important technological materials for catalysis and solid oxide fuel cell applications. Their functionality often depends on oxygen diffusivity and mobility through complex oxide heterostructures, which can be significantly impacted by structural and chemical modifications, such as doping. Further, when utilized within electrochemical cells, interfacial reactions with other components (e.g., Ni‐ and Cr‐based alloy electrodes and interconnects) can influence the perovskite's reactivity and ion transport, leading to complex dependencies that are difficult to control in real‐world environments. Here, this work uses isotopic tracers and atom probe tomography to directly visualize oxygen diffusion and transport pathways across perovskite and metal‐perovskite heterostructures, that is, (Ni‐Cr coated) Sr‐doped lanthanum ferrite (La0.5Sr0.5FeO3; LSFO). Annealing in 18O2(g) results in elemental and isotopic redistributions through oxygen exchange (OE) in the LSFO while Ni‐Cr undergoes oxidation via multiple mechanisms and transport pathways. Complementary density functional theory calculations at experimental conditions provide rationale for OE reaction mechanisms and reveal a complex interplay of different thermodynamic and kinetic drivers. These results shed light on the fundamental coupling of defects and oxygen transport in an important class of catalytic materials.

Published
2023
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9. Probing the Damage Recovery Mechanism in Irradiated Stainless Steels Using In-Situ Microcantilever Bending Test

Author

Keyou S. Mao, Hao Wang, Haozheng J. Qu, Kayla H. Yano, Philip D. Edmondson, Cheng Sun, and Janelle P. Wharry

Subjects
irradiation, helium, laser weld, microcantilever, crack, Technology
Abstract

Single crystalline microcantilevers are fabricated from the base metal and heat-affected zone (HAZ) of a laser welded, neutron irradiated austenitic stainless steel, for scanning electron microscope (SEM) in-situ bending. In the HAZ, cantilevers exhibit higher yield point and lower crack tip blunting displacement than in the base metal and unirradiated archive specimen. These results suggest that radiation-induced defects harden the base metal, whereas the HAZ exhibits annealing of defects leading to mechanical softening. Dislocation nucleation ahead of the crack tip is responsible for ductile blunting behavior and provides a pathway to mitigating helium-induced cracking during weld repairs of irradiated materials.

Published
2022
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11. Thermally Altered Subsurface Material of Asteroid 162173 Ryugu

Author

K Kitazato, R E Milliken, T Iwata, M Abe, M Ohtake, S Matsuura, Y Takagi, T Nakamura, T Hiroi, M Matsuoka, L Riu, Y Nakauchi, K Tsumura, T Arai, H Senshu, N Hirata, M A Barucci, R Brunetto, C Pilorget, F Poulet, J-P Bibring, D L Domingue, F Vilas, D Takir, E Palomba, A Galiano, D Perna, T Osawa, M Komatsu, A Nakato, N Takato, T Matsunaga, M Arakawa, T Saiki, K Wada, T Kadono, H Imamura, H Yano, K Shirai, M Hayakawa, C Okamoto, H Sawada, K Ogawa, Y Iijima, S Sugita, R Honda, T Morota, S Kameda, E Tatsumi, Y Cho, K Yoshioka, Y Yokota, N Sakatani, M Yamada, T Kouyama, H Suzuki, C Honda, N Namiki, T Mizuno, K Matsumoto, H Noda, Y Ishihara, R Yamada, K Yamamoto, F Yoshida, S Abe, A Higuchi, Y Yamamoto, T Okada, Y Shimaki, R.Noguchi, A Miura, S Tachibana, H Yabuta, M Ishiguro, H Ikeda, H Takeuchi, T Shimada, O Mori, S Hosoda, R Tsukizaki, S Soldini, M Ozaki, F Terui, N Ogawa, Y Mimasu, G Ono, K Yoshikawa, C Hirose, A Fujii, T Takahashi, S Kikuchi, Y Takei, T Yamaguchi, S. Nakazawa, S Tanaka, M Yoshikawa, S Watanabe, and Y Tsuda

Subjects
Lunar and Planetary Science and Exploration
Abstract

Studies of meteorite analysis and theoretical modeling have indicated the possibility that some carbonaceous near-Earth asteroids are thermally altered due to radiative heating during close approaches to the Sun in addition to parent body processes (Nakamura, 2005; Marchi et al., 2009; Chaumard et al., 2012). In April 2019, the Hayabusa2 mission successfully completed an artificial impact experiment on the carbonaceous near-Earth asteroid 162173 Ryugu (Arakawa et al., 2020), which provided an opportunity to investigate the effects of radiative heating through the exposed subsurface material. Here we report observations of the Ryugu’s subsurface material by the Near-Infrared Spectrometer (NIRS3) on the Hayabusa2 spacecraft. Spectra of the subsurface material exhibit a slightly stronger and peak-shifted hydroxyl absorption feature compared to that observed for the surface, indicating that space weathering and/or radiative heating caused a subtle change in the spectrum of Ryugu surface. However, the shape of the absorption feature still suggests that the subsurface material experienced heating above 300 ˚C similar to the surface. In contrast, our thermal modeling shows that radiative heating does not increase the subsurface temperature at 1 m depth above 200 ˚C even if the semimajor axis is reduced down to 0.344 au. This supports that the Ryugu material would have been preferentially altered due to radiogenic and/or impact heating on the parent body rather than radiative heating.

Published
2021
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12. Dose rate dependent cation & anion radiation enhanced diffusion in hematite

Author

Kayla H. Yano, Aaron A. Kohnert, Tiffany C. Kaspar, Sandra D. Taylor, Steven R. Spurgeon, Hyosim Kim, Yongqiang Wang, Blas P. Uberuaga, and Daniel K. Schreiber

Subjects
Renewable Energy, Sustainability and the Environment, General Materials Science, General Chemistry
Abstract

Irradiation induced non-equilibrium point defect populations influence mass transport in oxides, which in turn affects their stability and performance in hostile environments. In this study a strong dose rate dependence is observed.

Published
2022
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13. Prevalence of Smqnr and plasmid-mediated quinolone resistance determinants in clinical isolates of Stenotrophomonas maltophilia from Japan: novel variants of Smqnr

Author

H. Kanamori, H. Yano, A. Tanouchi, R. Kakuta, S. Endo, S. Ichimura, M. Ogawa, M. Shimojima, S. Inomata, D. Ozawa, T. Aoyagi, D.J. Weber, and M. Kaku

Subjects
Antimicrobial susceptibility, Japan, plasmid-mediated quinolone resistance (PMQR), Smqnr, Stenotrophomonas maltophilia, Infectious and parasitic diseases, RC109-216
Abstract

Stenotrophomonas maltophilia is an important pathogen in healthcare-associated infections. S. maltophilia may contain Smqnr, a quinolone resistance gene encoding the pentapeptide repeat protein, which confers low-level quinolone resistance upon expression in a heterologous host. We investigated the prevalence of Smqnr and plasmid-mediated quinolone resistance (PMQR) determinants in S. maltophilia isolates from Japan. A total of 181 consecutive and nonduplicate clinical isolates of S. maltophilia were collected from four areas of Japan. The antimicrobial susceptibility profiles for these strains were determined. PCR was conducted for Smqnr and PMQR genes, including qnrA, qnrB, qnrC, qnrS, aac(6′)-Ib and qepA. PCR products for Smqnr and aac(6′)-Ib were sequenced. For the S. maltophilia isolates containing Smqnr, pulsed-field gel electrophoresis (PFGE) was performed using XbaI. Resistance rates to ceftazidime, levofloxacin, trimethoprim–sulfamethoxazole, chloramphenicol and minocycline were 67.4%, 6.1%, 17.7%, 8.8% and 0%, respectively. The minimum inhibitory concentration required to inhibit the growth of 50% and 90% of organisms were 0.5 and 2 mg/L for moxifloxacin but 1 and 4 mg/L for levofloxacin, respectively. Smqnr was detected in 104 of the 181 S. maltophilia isolates (57.5%), and the most frequent was Smqnr6, followed by Smqnr8 and Smqnr11. Eleven novel variants from Smqnr48 to Smqnr58 were detected. The 24 Smqnr-containing S. maltophilia isolates were typed by PFGE and divided into 21 unique types. Nine S. maltophilia isolates (5.0%) carried aac(6′)-Ib-cr. No qnr or qepA genes were detected. This study describes a high prevalence of Smqnr and novel variants of Smqnr among S. maltophilia from Japan. Continuous antimicrobial surveillance and further molecular epidemiological studies on quinolone resistance in S. maltophilia are needed.

Published
2015
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14. Radiation Enhanced Anion Diffusion in Chromia

Author

Kayla H. Yano, Aaron A. Kohnert, Tiffany C. Kaspar, Sandra D. Taylor, Steven R. Spurgeon, Hyosim Kim, Yongqiang Wang, Blas P. Uberuaga, and Daniel K. Schreiber

Subjects
General Energy, Physical and Theoretical Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Published
2021
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15. Corn production for silage intercropped with forage in the farming-cattle breeding integration

Author

Veridiana Z. de Mendonça, Luiz M. M. de Mello, Francisco C. B. L. Pereira, José O. da R. Silva, and Élcio H. Yano

Subjects
direct sowing, interspecific competition, sowing mode, mulching, Agriculture (General), S1-972
Abstract

Corn cropping for silage, due to the plant material exportation, intercropping with forage provides greater ground cover and straw formation for the Direct Planting System (DPS) continuity. The objective of this study was to evaluate corn production for silage in DPS intercropped with four forages (Urochloa brizantha cv. Marandu, U. ruziziensis cv. Ruziziensis, Panicum maximum cv. Tanzânia and P. maximum cv. Áries). We applied three sowing methods (in row together with corn fertilizer; by no-till sowing simultaneously to corn sowing and at V4 corn stage) and corn without intercropping. The experiment was conducted in autumn/ winter of 2010, in Selvíria - MS, in a randomized block design in factorial arrangement (4 x 3 + 1) and 4 replications. For corn, we evaluated plant height, basal stem diameter, initial and final stand and silage production and for forage dry matter production. Morphological characteristics and corn yield were not affected by intercropping when compared to sole corn crop. Forage dry matter production sown in corn row with fertilizer is a highlight, which in addition to providing greater productivity, harnesses the operation during sowing.

Published
2014
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17. Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples

Author

T. Nakamura, M. Matsumoto, K. Amano, Y. Enokido, M. E. Zolensky, T. Mikouchi, H. Genda, S. Tanaka, M. Y. Zolotov, K. Kurosawa, S. Wakita, R. Hyodo, H. Nagano, D. Nakashima, Y. Takahashi, Y. Fujioka, M. Kikuiri, E. Kagawa, M. Matsuoka, A. J. Brearley, A. Tsuchiyama, M. Uesugi, J. Matsuno, Y. Kimura, M. Sato, R. E. Milliken, E. Tatsumi, S. Sugita, T. Hiroi, K. Kitazato, D. Brownlee, D. J. Joswiak, M. Takahashi, K. Ninomiya, T. Takahashi, T. Osawa, K. Terada, F. E. Brenker, B. J. Tkalcec, L. Vincze, R. Brunetto, A. Aléon-Toppani, Q. H. S. Chan, M. Roskosz, J.-C. Viennet, P. Beck, E. E. Alp, T. Michikami, Y. Nagaashi, T. Tsuji, Y. Ino, J. Martinez, J. Han, A. Dolocan, R. J. Bodnar, M. Tanaka, H. Yoshida, K. Sugiyama, A. J. King, K. Fukushi, H. Suga, S. Yamashita, T. Kawai, K. Inoue, A. Nakato, T. Noguchi, F. Vilas, A. R. Hendrix, C. Jaramillo-Correa, D. L. Domingue, G. Dominguez, Z. Gainsforth, C. Engrand, J. Duprat, S. S. Russell, E. Bonato, C. Ma, T. Kawamoto, T. Wada, S. Watanabe, R. Endo, S. Enju, L. Riu, S. Rubino, P. Tack, S. Takeshita, Y. Takeichi, A. Takeuchi, A. Takigawa, D. Takir, T. Tanigaki, A. Taniguchi, K. Tsukamoto, T. Yagi, S. Yamada, K. Yamamoto, Y. Yamashita, M. Yasutake, K. Uesugi, I. Umegaki, I. Chiu, T. Ishizaki, S. Okumura, E. Palomba, C. Pilorget, S. M. Potin, A. Alasli, S. Anada, Y. Araki, N. Sakatani, C. Schultz, O. Sekizawa, S. D. Sitzman, K. Sugiura, M. Sun, E. Dartois, E. De Pauw, Z. Dionnet, Z. Djouadi, G. Falkenberg, R. Fujita, T. Fukuma, I. R. Gearba, K. Hagiya, M. Y. Hu, T. Kato, T. Kawamura, M. Kimura, M. K. Kubo, F. Langenhorst, C. Lantz, B. Lavina, M. Lindner, J. Zhao, B. Vekemans, D. Baklouti, B. Bazi, F. Borondics, S. Nagasawa, G. Nishiyama, K. Nitta, J. Mathurin, T. Matsumoto, I. Mitsukawa, H. Miura, A. Miyake, Y. Miyake, H. Yurimoto, R. Okazaki, H. Yabuta, H. Naraoka, K. Sakamoto, S. Tachibana, H. C. Connolly, D. S. Lauretta, M. Yoshitake, M. Yoshikawa, K. Yoshikawa, K. Yoshihara, Y. Yokota, K. Yogata, H. Yano, Y. Yamamoto, D. Yamamoto, M. Yamada, T. Yamada, T. Yada, K. Wada, T. Usui, R. Tsukizaki, F. Terui, H. Takeuchi, Y. Takei, A. Iwamae, H. Soejima, K. Shirai, Y. Shimaki, H. Senshu, H. Sawada, T. Saiki, M. Ozaki, G. Ono, T. Okada, N. Ogawa, K. Ogawa, R. Noguchi, H. Noda, M. Nishimura, N. Namiki, S. Nakazawa, T. Morota, A. Miyazaki, A. Miura, Y. Mimasu, K. Matsumoto, K. Kumagai, T. Kouyama, S. Kikuchi, K. Kawahara, S. Kameda, T. Iwata, Y. Ishihara, M. Ishiguro, H. Ikeda, S. Hosoda, R. Honda, C. Honda, Y. Hitomi, N. Hirata, T. Hayashi, M. Hayakawa, K. Hatakeda, S. Furuya, R. Fukai, A. Fujii, Y. Cho, M. Arakawa, M. Abe, Y. Tsuda, Tohoku University [Sendai], NASA Johnson Space Center (JSC), NASA, The University of Tokyo (UTokyo), Tokyo Institute of Technology [Tokyo] (TITECH), Institute of Space and Astronautical Science (ISAS), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), ASU School of Earth and Space Exploration (SESE), Arizona State University [Tempe] (ASU), Planetary Exploration Research Center [Chiba] (PERC), Chiba Institute of Technology (CIT), Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] (EAPS), Massachusetts Institute of Technology (MIT), Nagoya University, Department of Earth and Planetary Science [Tokyo], Graduate School of Science [Tokyo], The University of Tokyo (UTokyo)-The University of Tokyo (UTokyo), Pôle Planétologie du LESIA, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Guangzhou Institute of Geochemistry, Ritsumeikan University, Japan Synchrotron Radiation Research Institute [Hyogo] (JASRI), Institute of Low Temperature Science [Sapporo], Hokkaido University [Sapporo, Japan], Department of Earth, Environmental and Planetary Sciences [Providence], Brown University, The University of Aizu, University of Washington [Seattle], Osaka University, Kavli Institute for the Physics and Mathematics of the Universe [Tokyo] (Kavli IPMU), The University of Tokyo Institutes for Advanced Study (UTIAS), Japan Atomic Energy Agency, Goethe-University Frankfurt am Main, Department of Inorganic and Physical Chemistry, Ghent University, Universiteit Gent = Ghent University (UGENT), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Department of Earth Sciences, Royal Holloway, University of London, Egham, Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Advanced Photon Source [ANL] (APS), Argonne National Laboratory [Lemont] (ANL)-University of Chicago-US Department of Energy, Kindai University, Kyushu University, Department of Earth and Atmospheric Sciences [Houston], University of Houston, Texas Materials Institute (TMI), University of Texas at Austin [Austin], Department of Geoscience, Virginia Tech, Blacksburg, VA, United States, National Institute for Materials Science (NIMS), Department of Earth Sciences [NHM London] (DES-NHM), The Natural History Museum [London] (NHM), Kanazawa University (KU), Graduate University for Advanced Studies [Hayama] (SOKENDAI), Division of Earth and Planetary Sciences [Kyoto], Kyoto University, Planetary Science Institute [Tucson] (PSI), Pennsylvania State University (Penn State), Penn State System, California State University [San Marcos] (CSUSM), Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Division of Geological and Planetary Sciences [Pasadena], California Institute of Technology (CALTECH), University of Shizuoka, Ehime University [Matsuyama, Japon], European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), KEK (High energy accelerator research organization), Hitachi, Ltd, Institute for integrated Radiation and Nuclear Science (KURNS), National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (AIST), Department of Physics, Rikkyo University, Tokyo, Japan Fine Ceramics Center (JFCC), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), The Aerospace Corporation, Earth-Life Science Institute [Tokyo] (ELSI), University of Chinese Academy of Sciences [Beijing] (UCAS), Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Photone Sciences, Deutsches Elektronen-Synchrotron (DESY), Graduate School of Life Science, University of Hyogo, International Christian University, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Center for Advanced Radiation Sources [University of Chicago] (CARS), University of Chicago, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Physique (ICP), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Graduate School of Information Science [Nagoya], Department of Natural History Sciences, Department of Earth and Planetary Sciences [Fukuoka], Graduate School of Advanced Science and Engineering [Higashi-Hiroshima], Hiroshima University, Rowan University, Lunar and Planetary Laboratory [University of Arizona] (LPL), University of Arizona, Kanagawa Institute of Technology, Marine Works Japan Ltd., Faculty of Science, Niigata University, National Astronomical Observatory of Japan (NAOJ), Department of Physics and Astronomy [Seoul], Seoul National University [Seoul] (SNU), Kochi University, Department of Planetology, Graduate School of Science, Graduate School of Science [Kobe], Kobe University-Kobe University, Kobe University, Supported by KAKENHI from the Japanese Society for Promotion of Science (JSPS), grants JP20H00188 and 19H05183 to T.N., JP19K14776 to M.M., 21K18645 to T.M. and K.S., JP20H00205 to A.Ts., M.M., A.M. and J.M., 17H06458 to K.F., Y.T., S.Y. and M.K., JP17H06459 to T.N., T.U., S.W., M.M., N.N., T.M., T.O., Y.S., N.S., and R.N., JP15H05695 to A.Ts. and K.U., 20H05846 to S.T., JP17H06457 to H.G., JP17H06458 to Y. T. and K. F., JP19H00726 to K.K., H. G., and T.M., JP21J13337 to K.A., and JP18H05456,JP20H00189 to K.S., 18H05463 to T.T., S.N., and S.W., 18H05460 to K.N. and T.O., 18H05464 to Y.M., 18H05457 to K.N., T.T., S.W., and Y.M., and JP18H05479 to M.U. Also supported by the JSPS Core-to-Core program ' International Network of Planetary Sciences', and from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) (grants JPMXS0450200421 and JPMXS0450200521) to SS. A.K. acknowledges funding support from UK Research and Innovation (UKRI) grant MR/T020261/1. A.B. acknowledges funding support from NASA Emerging Worlds grant - 80NSSC18K0731. P.B. acknowledges funding from the European Research Council (ERC) under grant agreement no. 771691 (Solarys) and the CNES., and European Project: 771691,SOLARYS

Subjects
Multidisciplinary, [SDU]Sciences of the Universe [physics], Ryugu Hayabusa2 Carbonaceous asteroid Sample return
Abstract

Samples of the carbonaceous asteroid Ryugu were brought to Earth by the Hayabusa2 spacecraft. We analyzed 17 Ryugu samples measuring 1 to 8 millimeters. Carbon dioxide–bearing water inclusions are present within a pyrrhotite crystal, indicating that Ryugu’s parent asteroid formed in the outer Solar System. The samples contain low abundances of materials that formed at high temperatures, such as chondrules and calcium- and aluminum-rich inclusions. The samples are rich in phyllosilicates and carbonates, which formed through aqueous alteration reactions at low temperature, high pH, and water/rock ratios of

Published
2022
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18. Resolving diverse oxygen transport pathways across Sr-doped lanthanum ferrite and metal-perovskite heterostructures

Author

Sandra D. Taylor, Kayla H. Yano, Michel Sassi, Bethany E. Matthews, Elizabeth J. Kautz, Sten V. Lambeets, Sydney Neuman, Daniel K. Schreiber, Le Wang, Yingge Du, and Steven R. Spurgeon

Subjects
Condensed Matter - Materials Science, Mechanics of Materials, Mechanical Engineering, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences
Abstract

Perovskite structured transition metal oxides are important technological materials for catalysis and solid oxide fuel cell applications. Their functionality often depends on oxygen diffusivity and mobility through complex oxide heterostructures, which can be significantly impacted by structural and chemical modifications, such as doping. Further, when utilized within electrochemical cells, interfacial reactions with other components (e.g. Ni- and Cr-based alloy electrodes and interconnects) can influence the perovskite's reactivity and ion transport, leading to complex dependencies that are difficult to control in real-world environments. Here we use isotopic tracers and atom probe tomography to directly visualize oxygen diffusion and transport pathways across perovskite and metal-perovskite heterostructures, i.e. (Ni-Cr coated) Sr-doped lanthanum ferrite (LSFO). Annealing in 18O2(g) results in elemental and isotopic redistributions through oxygen exchange (OE) in the LSFO while Ni-Cr undergoes oxidation via multiple mechanisms and transport pathways. Complementary density functional theory (DFT) calculations at experimental conditions provide rationale for OE reaction mechanisms and reveal a complex interplay of different thermodynamic and kinetic drivers. Our results shed light on the fundamental coupling of defects and oxygen transport in an important class of catalytic materials., 39 pages, 10 figures

Published
2022

19. Modalities for soil preparation and gypsum application in ultisol: stem productivity of sugarcane

Author

Ronaldo C. Lima, Luiz M. M. de Mello, Élcio H. Yano, José O. R. da Silva, and André L. Cesarin

Subjects
chemical attributes, mechanization, gypsum application, Saccharum spp, Agriculture (General), S1-972
Abstract

The study was conducted in an area of expansion of sugarcane at Vale do Paraná factory in Suzanápolis city - São Paulo (SP), in Brazil, in the northwestern region of the State of São Paulo. It was used the sugarcane variety RB92-5345, 1.5m of spacing between rows, in an Ultisol. The study aimed to evaluate the productivity of sugarcane and first ratoon and some soil chemical attributes in function of soil tillage and application or not of gypsum. The experimental design was randomized blocks with six treatments, in a factorial 3x2 and six replicates, the main treatments were soil tillage with three equipments, moldboard plow, chisel plow, and heavy harrow, and two secondary treatments with application of 1 t ha-1of gypsum and no gypsum. After each harvest of cane, the soil was characterized as to its fertility indicators in layers of 0.0-0.15; 0.15-0.30 and 0.30-0.45m. Differences in values of soil chemical attributes due to the methods of preparation occurred in the sugarcane did not last until the harvest of the 1st ratoon cane, and also did not influence the crop productivity. The gypsum application resulted in higher values of total recoverable sugar (TRS) and the productivity of tons of stems per hectare (TSH) to sugarcane and 1st ratoon cane, respectively, confirming the initial hypothesis.

Published
2013
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20. Adatom-Driven Oxygen Intermixing during the Deposition of Oxide Thin Films by Molecular Beam Epitaxy

Author

Tiffany C. Kaspar, Peter Hatton, Kayla H. Yano, Sandra D. Taylor, Steven R. Spurgeon, Blas P. Uberuaga, and Daniel K. Schreiber

Subjects
Mechanical Engineering, General Materials Science, Bioengineering, General Chemistry, Condensed Matter Physics
Abstract

Thin film deposition from the vapor phase is a complex process involving adatom adsorption, movement, and incorporation into the growing film. Here, we present quantitative experimental data that reveals anion intermixing over long length scales during the deposition of epitaxial Fe

Published
2022

21. Demanda energética nas operações mecanizadas na silagem de milho no sistema de 'silo bag' Energy demand in the mechanized operations in the corn silage in the silo bag system

Author

André S. Seki, Sérgio H. Benez, Paulo R. A. Silva, Élcio H. Yano, and Luiz M. M. Mello

Subjects
consumo de energia, ensilagem, grão úmido, energy consumption, ensilage, humid grains, Agriculture (General), S1-972
Abstract

Foi avaliado o consumo energético das operações mecanizadas envolvidas na produção de silagem de planta inteira e silagem de "grão úmido" de milho, tendo como referência o processamento seco desse cereal. O ensaio foi conduzido na Fazenda Experimental Lageado, pertencente à Faculdade de Ciências Agronômicas, e nas instalações da Faculdade de Medicina Veterinária e Zootecnia - UNESP, localizada no município de Botucatu - SP. O delineamento experimental foi em blocos ao acaso, com parcelas subdivididas no tempo (três épocas de colheita: silagem de planta inteira, silagem de "grão úmido" e colheita de grãos secos), com 10 repetições. As análises estatísticas foram realizadas por meio do programa ESTAT, pelo teste de média de Tukey, a 5% de probabilidade. A silagem de planta inteira teve o maior consumo de combustível por área. A secagem dos grãos de 15,5% para 13% foi responsável por 87% do gasto de energia por área. A silagem de "grão úmido" demandou o menor uso de energia por área nas operações mecanizadas.This work aims to evaluate the energy consumption of the mechanized operations involved in the silage production of entire plant and silage of humid maize, having as reference the dry processing of this cereal. The experiment was on Lageado Experimental Farm of the Agronomy School, and the Education Research and Production Farm, of the Veterinary School of - UNESP - São Paulo State University - Botucatu Campus. The experiment design was in randomized blocks with parts subdivided in time (three times of harvest: silage of entire plant, silage of humid grains and harvest of dry grains), with 10 repetitions. The statistical analyses were performed with ESTAT software, and Tukey test at 5% of probability. The highest fuel consumption per area was reported for the ensilage of entire plant. The highest energy demand per area was reported for the processing of dry grain, as drying is responsible for 87% of the energy expense. The ensilage of humid grain demanded the lesser use of energy per area in the mechanized operations.

Published
2009
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22. The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential

Author

N. Kfoury-Beaumont, R. Prakasam, S. Pondugula, J. S. Lagas, S. Matkovich, P. Gontarz, L. Yang, H. Yano, A. H. Kim, J. B. Rubin, and K. L. Kroll

Subjects
Physiology, Carcinogenesis, Stem Cells, Cell Biology, Plant Science, General Biochemistry, Genetics and Molecular Biology, Epigenesis, Genetic, Histones, Structural Biology, Mutation, Brain Stem Neoplasms, Humans, General Agricultural and Biological Sciences, Child, Ecology, Evolution, Behavior and Systematics, Developmental Biology, Biotechnology, Cell Proliferation
Abstract

BackgroundNeurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis. For example, lysine 27 to methionine mutation (H3K27M) in theH3F3Agene occurs frequently in Diffuse Intrinsic Pontine Gliomas (DIPGs), the most aggressive pediatric glioma. As H3K27M mutation is necessary but insufficient to cause DIPGs, it is accompanied by additional mutations in tumors. However, how H3K27M alone increases vulnerability to DIPG tumorigenesis remains unclear.ResultsHere, we used human embryonic stem cell models with this mutation, in the absence of other DIPG contributory mutations, to investigate how H3K27M alters cellular proliferation and differentiation. We found that H3K27M increased stem cell proliferation and stem cell properties. It interfered with differentiation, promoting anomalous mesodermal and ectodermal gene expression during both multi-lineage and germ layer-specific cell specification, and blocking normal differentiation into neuroectoderm. H3K27M mutant clones exhibited transcriptomic diversity relative to the more homogeneous wildtype population, suggesting reduced fidelity of gene regulation, with aberrant expression of genes involved in stem cell regulation, differentiation, and tumorigenesis. These phenomena were associated with global loss of H3K27me3 and concordant loss of DNA methylation at specific genes in H3K27M-expressing cells.ConclusionsTogether, these data suggest that H3K27M mutation disrupts normal differentiation, maintaining a partially differentiated state with elevated clonogenicity during early development. This disrupted response to early developmental cues could promote tissue properties that enable acquisition of additional mutations that cooperate with H3K27M mutation in genesis of DMG/DIPG. Therefore, this work demonstrates for the first time that H3K27M mutation confers vulnerability to gliomagenesis through persistent clonogenicity and aberrant differentiation and defines associated alterations of histone and DNA methylation.

Published
2021

23. Integração agricultura-pecuária em plantio direto: produção de forragem e resíduo de palha após pastejo Integration agriculture-pasture in no-tillage system: forage yield and mulch residue after animal grazing

Author

Luiz M. M. de Mello, Élcio H. Yano, Karem C. P. Narimatsu, Celso M. Takahashi, and Émerson Borghi

Subjects
sorgo forrageiro, pastejo rotacionado, produção de palha, sorghum forage, rotating grazing, mulch production, Agriculture (General), S1-972
Abstract

O objetivo deste trabalho foi verificar, no sistema integração agricultura-pecuária, a possibilidade de utilizar uma cultura para pastejo cujos resíduos permitam produção de palha suficiente para a manutenção do plantio direto, bem como avaliar a produção da forrageira e do resíduo em diferentes distâncias em relação ao centro do pivô, em três épocas, e o desempenho econômico do sistema. Avaliaram-se o impacto do pastejo rotacionado de sorgo forrageiro em plantio direto, sob irrigação em um pivô central de 75 ha, sobre a produção de matéria seca do sorgo forrageiro, a quantidade de resíduos, o custo de produção e o ganho de peso animal. O ensaio foi conduzido num Latossolo Vermelho Distrófico. O delineamento experimental utilizado foi o de blocos ao acaso, com parcelas subdivididas, com quatro tratamentos principais: locais de amostragem em diferentes distâncias em relação ao centro do pivô; três tratamentos secundários (ciclos de pastejos) e sete repetições (sete piquetes de 9,37 ha para pastejo, dispostos na forma de "pizza"). Os resultados permitiram concluir que: a produção do sorgo forrageiro foi suficiente para permitir um ganho 621 kg ha-1 de peso vivo e a quantidade de resíduos de sorgo após o pastejo foi suficiente para suprir o aporte anual de matéria seca de palha necessária para a manutenção do plantio direto; a área, após os pastejos, continuou passível de ser explorada no sistema de plantio direto, e o sistema pesquisado mostrou-se técnica e economicamente viável.The objective of this research was to verify, in an integrated agriculture-pasture system, the viability of using a pasture crop which residue allow enough mulch for a no-tillage system management. Forage yield and residue at different distances from a central pivot, in three periods, and an economical analysis of the system were also evaluated. The impact of rotating grazing, in a 75 ha no-tillage sorghum forage system, irrigated by a central pivot, on forage sorghum dry matter yield, mulch residues and animal weight gain were evaluated. The site presented a dystrophic, dark red "latossol" (oxisol). The experimental design was a split plot, with four main (sampling points at different distances from the central of the pivot) and three secondary (grazing periods) treatments, with seven replications (seven 9.37 ha paddocks for grazing, in a pizza-like shape). Forage sorghum allowed a 621 kg ha-1 gain in live weight and the volume of sorghum mulch left after grazing was enough to sustain a no-tillage system. The area, even after grazing, provided conditions to be used in the no-tillage system, proving technically and economically feasible.

Published
2004
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24. Interface effect of Fe and Fe2O3 on the distributions of ion induced defects

Author

Hyosim Kim, Matthew R. Chancey, Thaihang Chung, Ian Brackenbury, Maciej O. Liedke, Maik Butterling, Eric Hirschmann, Andreas Wagner, Jon K. Baldwin, Ben K. Derby, Nan Li, Kayla H. Yano, Danny J. Edwards, Yongqiang Wang, and Farida A. Selim

Subjects
General Physics and Astronomy
Abstract

The stability of structural materials in extreme nuclear reactor environments—with high temperature, high radiation, and corrosive media—directly affects the lifespan of the reactor. In such extreme environments, an oxide layer on the metal surface acts as a passive layer protecting the metal underneath from corrosion. To predict the irradiation effect on the metal layer in these metal/oxide bilayers, nondestructive depth-resolved positron annihilation lifetime spectroscopy (PALS) and complementary transmission electron microscopy (TEM) were used to investigate small-scale defects created by ion irradiation in an epitaxially grown (100) Fe film capped with a 50 nm Fe2O3 oxide layer. In this study, the evolution of induced vacancies was monitored, from individual vacancy formation at low doses—10−5 dpa—to larger vacancy cluster formation at increasing doses, showing the sensitivity of positron annihilation spectroscopy technique. Furthermore, PALS measurements reveal how the presence of a metal–oxide interface modifies the distribution of point defects induced by irradiation. TEM measurements show that irradiation induced dislocations at the interface is the mechanism behind the redistribution of point defects causing their accumulation close to the interface. This work demonstrates that the passive oxide layers formed during corrosion impact the distribution and accumulation of radiation induced defects in the metal underneath and emphasizes that the synergistic impact of radiation and corrosion will differ from their individual impacts.

Published
2022
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25. Improving predictions of protein-protein interfaces by combining amino acid-specific classifiers based on structural and physicochemical descriptors with their weighted neighbor averages.

Author

Fábio R de Moraes, Izabella A P Neshich, Ivan Mazoni, Inácio H Yano, José G C Pereira, José A Salim, José G Jardine, and Goran Neshich

Subjects
Medicine, Science
Abstract

Protein-protein interactions are involved in nearly all regulatory processes in the cell and are considered one of the most important issues in molecular biology and pharmaceutical sciences but are still not fully understood. Structural and computational biology contributed greatly to the elucidation of the mechanism of protein interactions. In this paper, we present a collection of the physicochemical and structural characteristics that distinguish interface-forming residues (IFR) from free surface residues (FSR). We formulated a linear discriminative analysis (LDA) classifier to assess whether chosen descriptors from the BlueStar STING database (http://www.cbi.cnptia.embrapa.br/SMS/) are suitable for such a task. Receiver operating characteristic (ROC) analysis indicates that the particular physicochemical and structural descriptors used for building the linear classifier perform much better than a random classifier and in fact, successfully outperform some of the previously published procedures, whose performance indicators were recently compared by other research groups. The results presented here show that the selected set of descriptors can be utilized to predict IFRs, even when homologue proteins are missing (particularly important for orphan proteins where no homologue is available for comparative analysis/indication) or, when certain conformational changes accompany interface formation. The development of amino acid type specific classifiers is shown to increase IFR classification performance. Also, we found that the addition of an amino acid conservation attribute did not improve the classification prediction. This result indicates that the increase in predictive power associated with amino acid conservation is exhausted by adequate use of an extensive list of independent physicochemical and structural parameters that, by themselves, fully describe the nano-environment at protein-protein interfaces. The IFR classifier developed in this study is now integrated into the BlueStar STING suite of programs. Consequently, the prediction of protein-protein interfaces for all proteins available in the PDB is possible through STING_interfaces module, accessible at the following website: (http://www.cbi.cnptia.embrapa.br/SMS/predictions/index.html).

Published
2014
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26. Dopamine receptor activation increases HIV entry into primary human macrophages.

Author

Peter J Gaskill, Hideaki H Yano, Ganjam V Kalpana, Jonathan A Javitch, and Joan W Berman

Subjects
Medicine, Science
Abstract

Macrophages are the primary cell type infected with HIV in the central nervous system, and infection of these cells is a major component in the development of neuropathogenesis and HIV-associated neurocognitive disorders. Within the brains of drug abusers, macrophages are exposed to increased levels of dopamine, a neurotransmitter that mediates the addictive and reinforcing effects of drugs of abuse such as cocaine and methamphetamine. In this study we examined the effects of dopamine on HIV entry into primary human macrophages. Exposure to dopamine during infection increased the entry of R5 tropic HIV into macrophages, irrespective of the concentration of the viral inoculum. The entry pathway affected was CCR5 dependent, as antagonizing CCR5 with the small molecule inhibitor TAK779 completely blocked entry. The effect was dose-dependent and had a steep threshold, only occurring above 108 M dopamine. The dopamine-mediated increase in entry required dopamine receptor activation, as it was abrogated by the pan-dopamine receptor antagonist flupenthixol, and could be mediated through both subtypes of dopamine receptors. These findings indicate that the effects of dopamine on macrophages may have a significant impact on HIV pathogenesis. They also suggest that drug-induced increases in CNS dopamine may be a common mechanism by which drugs of abuse with distinct modes of action exacerbate neuroinflammation and contribute to HIV-associated neurocognitive disorders in infected drug abusers.

Published
2014
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27. The global cost of pelvic exenteration

Author

Michael E. Kelly, J. S. McGrath, Satish K Warrier, M. Quinn, Rami Radwan, D. Dietz, P. Tsarkov, Jean-Jacques Tuech, Søren Laurberg, Y. Tsukada, M. Fahy, P. C. Rasmussen, H. J. Kim, M. Chang, M. Bedford, S. Kaffenberger, David W. Larson, Joost Rothbarth, Klaus Weber, H. H. Wasmuth, G. Baseckas, Omer Aziz, Dean A. Harris, R. P. Baker, A. Quyn, C. Wakeman, N. Rajendran, M. Abraham-Nordling, V. George, A. Bui, F. D. McDermott, Wilt Jhw, L. Ghouti, B. Eyjólfsdóttir, Tarik Sammour, V. Hanchanale, W. L. Law, Roland S. Croner, Schizas Amp, Santiago Domingo, N. Abdul Aziz, W. Vasquez-Jimenez, Ian R. Daniels, M. M. Sørensen, F. Giner, Anna Martling, Frank A. Frizelle, L. Stocchi, Margues Cfs, E. Schwarzkopf, Kok Nfm, E. Pappou, Paris P. Tekkis, T. Akiyoshi, T. Eglinton, J. L. Ng, T. Swartling, Peter M. Sagar, A. B. Bremers, Hagemans Jaw, Geerard L. Beets, K. Boyle, G. J. Chang, G. V. Kandaswamy, W. Alberda, H. Yano, A. J. Colquhoun, S. Carvalhal, V. Scripcariu, S. Rasheed, David J. Hochman, Quentin Denost, D. Proud, J. L. Garcia-Sabrido, M. Codd, R. Glynn, L. Damjanovic, K. Stitzenberg, Jurriaan B. Tuynman, P. Chong, H. Kristensen, M. Limbert, R. Rocha, Malcolm S Wilson, N. Abecasis, M. Duff, Cees Verhoef, T. Golda, Martyn Evans, Conor P. Delaney, Hidde M. Kroon, T. G. Mullaney, Bashar Safar, S. E. Regenbogen, M. Cosimelli, E. Angenete, M. S. Khan, Adele Burgess, D. Shida, A. Oliver, Raza Sayyed, R. Thurairaja, M. Davies, H. Clouston, S. Kumar, M. L. Lydrup, C. Deutsch, M. Kusters, Aalbers Agj, M. Rottoli, M. B. Nielsen, Anthony Simpson, Christopher R. Mantyh, Andrew C. Peterson, M Brunner, E. J. Tan, Monson Jrt, J. Wild, John Beynon, M. A. Gallego, L. Bordeianou, N. A. Stylianides, F. Fleming, Meijerink Wjhj, N. Ginther, Neil J. Smart, A. Caycedo-Marulanda, M. H. Chew, Neto Jwm, S. Biondo, L. Castro, Nicola S Fearnhead, Burger Jwa, Christos Kontovounisios, P. J. Lee, S. Tsukamoto, Ionut Negoi, Z. Lakkis, N. Campain, M. R. Weiser, G. Hellawell, A. M. Solbakken, E. Burns, B. Nguyen, Jüri Teras, J. M. Enrique-Navascues, M. Andric, Deena Harji, E. L. Toh, G. Palmer, Rory Kokelaar, M. Rochester, L. Gentilini, W. H. Turner, S. Malde, Roel Hompes, D. van Zoggel, Andrew G Renehan, G. Vizzielli, D. Steffens, K. Flatmark, A. Corr, C. E. Koh, D. Burling, Chelliah Selvasekar, D. Patsouras, B. Griffiths, Kay Uehara, P. Smart, K. L. Mathis, A. C. Lynch, P. L. Berg, Gianluca Pellino, Alex H. Mirnezami, Michael J. Solomon, S. R. Kelley, C. Roxburgh, H. Kim, Y. Kanemitsu, E. García-Granero, A. Merchea, Emanuele Rausa, S. R. Steele, Wheeler Jmd, D. McArthur, M. A. Zappa, Brian K. Bednarski, E. Espin-Basany, I. Shaikh, Nieuwenhuijzen Gap, A. K. Chok, S. Kapur, G. H. van Ramshorst, Chan Kkl, Eric J. Dozois, Susanne Merkel, B. Yip, J. Park, A. Sahai, Anthony Antoniou, C. Taylor, Matthew R. Albert, R. J. Davies, Sarah T O'Dwyer, Torbjörn Holm, P. A. Sutton, Albert Wolthuis, H. Sumrien, A. Lyons, J. Yip, T. Swartking, Declan Collins, M. L. George, G. Poggioli, Des C. Winter, J. Folkesson, P. Buchwald, D. S. Keller, Stein Gunnar Larsen, J. Rohila, Kirk K. S. Austin, J. Joshua Smith, P. J. Nilsson, Ramzi M. Helewa, J. R. Morton, Peter Coyne, H. K. Christensen, Rutten Hjt, John T. Jenkins, A. M. Mehta, M. Bali, R. N. Yoo, A. Saklani, Alexander G. Heriot, M. Coscia, B. Bebington, Werner Hohenberger, Víctor Lago, T. Skeie-Jensen, R. Auer, Voogt Elk, Surgery, Poggioli, G, Rottoli, M, Gentilini, L, and Coscia, M.

Subjects
medicine.medical_specialty, Pelvic exenteration, Manchester Cancer Research Centre, business.industry, General surgery, medicine.medical_treatment, ResearchInstitutes_Networks_Beacons/mcrc, advanced rectal cancer, MEDLINE, Perioperative, Global Health, Pelvic Exenteration, cost, recurrent rectal cancer, medicine, Global health, Humans, Surgery, Hospital Costs, business
Abstract

No abstract available

Published
2020
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29. Utility of 123I-iomazenil single-photon emission computed tomography as an indicator of neurological irreversibility in patients with non-convulsive status epilepticus

Author

Ohmura K, Noriyuki Nakayama, J. Shinoda, T. Iwama, H. Yano, Yoshimura K, and Kazuhiro Miwa

Subjects
medicine.diagnostic_test, business.industry, Convulsive status epilepticus, Medicine, In patient, Single-photon emission computed tomography, 123i iomazenil, business, Nuclear medicine
Published
2020
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30. EP936 A feasibility study of gemcitabine and bevacizumab in women with platinum-resistant recurrent ovarian cancer

Author

S Nagao, A Kogiku, M Ota, K Yamamoto, M Narita, K Shimada, H Nagazawa, T Shibutani, T Jimi, H Yano, M Kitai, T Shiozaki, K Matsuoka, and S Yamaguchi

Subjects
medicine.medical_specialty, Chemotherapy, Bevacizumab, business.industry, medicine.medical_treatment, Combination chemotherapy, Neutropenia, medicine.disease, Gastroenterology, Gemcitabine, Internal medicine, Medicine, Progression-free survival, business, Ovarian cancer, Febrile neutropenia, medicine.drug
Abstract

Introduction/Background In the AURELIA trial, adding of bevacizumab to chemotherapy significantly improved response and survival without problematic toxicity in women with platinum-resistant ovarian cancer. However, information about bevacizumab in combination with gemcitabine is insufficient. We conducted a feasibility study to assess clinical activity and toxicity. Methodology Women with platinum-resistant recurrent ovarian cancer who received one to three regimens of platinum-based chemotherapy were registered in this study. They received 15 mg/kg of bevacizumab intravenously on day 1 and gemcitabine 1000 mg/m2of gemcitabine intravenously on day 1 and 8 every 21 days to disease progression or unacceptable toxicity. The primary endpoint was completion rate of 3 cycles of chemotherapy. The secondary endpoints were clinical response rate, progression free survival,overall survival, and dose-limiting toxicity including bowel perforation, febrile neutropenia, and grade 4 thrombocytopenia. This study is registered with UMIN-CTR, number UMIN000016619. Results Between April 1, 2015 and December 31, 2018, 19 patients were enrolled into this study. There were 12 high grade serous, 1 endometrial, 4 clear cell, and 2 other types of carcinoma. Eighteen of 19 (95%) received 3 or more, and 9 (47%) received 6 or more cycles of study treatment. Objective responses were observed in 8 of 19 patients (42% overall; complete response 16%, partial response 26%), with an additional 8 (42%) having stable disease. Hematologic toxicity was neutropenia grade 3/4 in 9 (47%), anemia grade 3/4 in 2 (11%), thrombocytopenia grade 3/4 in 1 (5%). Non-hematologic toxicity included grade 3 hypertension in 1 (5%), grade 3 protein urea in one (5%) and possibly-related grade 3 interstitial pneumonia in 1 (5%). No patient encountered dose-limiting toxicity. Median progression free survival was 5.1 months, and median overall survival was 21.3 months. Conclusion Combination chemotherapy with gemcitabine and bevacizumab is feasible in women with platinum-resistant recurrent ovarian cancer. Disclosure Nothing to disclose.

Published
2019
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31. EP1056 Quality of life assessment before and after concentrated ascites reinfusion therapy in patients with advanced or recurrent gynecologic cancer: a prospective cohort study

Author

T Shiozaki, H Yano, K Matsuoka, M Narita, K Suzuki, S Nagao, K Shimada, T Shibutani, S Yamaguchi, T Jimi, M Kitai, K Yamamoto, and H Nakazawa

Subjects
Cart, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Debulking, medicine.disease, Quality of life, Internal medicine, Fallopian tube cancer, Ascites, Medicine, medicine.symptom, business, Adverse effect, Prospective cohort study
Abstract

Introduction/Background Concentrated ascites reinfusion therapy (CART) is currently applied widely to relieve symptoms in patients with malignant ascites. However, only few studies have investigated the ability of CART to improve or maintain quality of life (QOL). Therefore, we performed a prospective cohort study to evaluate the efficacy and safety of CART. Methodology From April 2018 to March 2019, 22 patients with gynecological malignancies received CART. We performed QOL assessment using the Japanese version of the M.D. Anderson Symptom Inventory (MDASI-J) at 24 h before and after CART. Results The 22 patients received a total of 41 CART sessions. This included 16 patients with epithelial ovarian cancer, 5 with peritoneal cancer, and 1 with fallopian tube cancer. CART was performed 24 times before or during neoadjuvant chemotherapy, twice before primary debulking surgery, and 15 times during chemotherapy to prevent recurrence. The mean amount of ascites collected was 2.9 L (0.75–6 L). The concentrations of total protein and albumin were maintained before and after CART (2.5 ± 0.58 g/dL and 2.8 ± 1.72 g/dL, respectively). The most common adverse event was fever [63.6% (14/22 patients) and 39.0% (16/41 sessions)], which is easily controllable by NSAIDs. No patient experienced severe adverse events. CART improved the symptom and interference scores of the MDASI-J significantly within 24 h of the procedure. Various symptoms associated with malignant ascites, especially appetite loss and fatigue, improved within the 24-h period following CART. The mean symptom scores of the MDASI-J decreased from 3.3 to 2.5, and the interference scores of the MDASI-J decreased from 5.2 to 4. Conclusion CART is an effective and relatively safe procedure for malignant ascites in patients with gynecologic cancer. In particular, QOL scores were improved by CART. Disclosure Nothing to disclose

Published
2019
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37. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere

Author

G. Abdellaoui, S. Abe, J.H. Adams Jr., A. Ahriche, D. Allard, L. Allen, G. Alonso, L. Anchordoqui, A. Anzalone, Y. Arai, K. Asano, R. Attallah, H. Attoui, M. Ave Pernas, S. Bacholle, M. Bakiri, P. Baragatti, P. Barrillon, S. Bartocci, J. Bayer, B. Beldjilali, T. Belenguer, N. Belkhalfa, R. Bellotti, A. Belov, K. Belov, K. Benmessai, M. Bertaina, P.L. Biermann, S. Biktemerova, F. Bisconti, N. Blanc, J. Błȩcki, S. Blin-Bondil, P. Bobik, M. Bogomilov, E. Bozzo, A. Bruno, K.S. Caballero, F. Cafagna, D. Campana, J-N. Capdevielle, F. Capel, A. Caramete, L. Caramete, P. Carlson, R. Caruso, M. Casolino, C. Cassardo, A. Castellina, C. Catalano, O. Catalano, A. Cellino, M. Chikawa, G. Chiritoi, M.J. Christl, V. Connaughton, L. Conti, G. Cordero, G. Cotto, H.J. Crawford, R. Cremonini, S. Csorna, A. Cummings, S. Dagoret-Campagne, C. De Donato, C. de la Taille, C. De Santis, L. del Peral, M. Di Martino, A. Diaz Damian, T. Djemil, I. Dutan, A. Ebersoldt, T. Ebisuzaki, R. Engel, J. Eser, F. Fenu, S. Fernández-González, J. Fernández-Soriano, S. Ferrarese, M. Flamini, C. Fornaro, M. Fouka, A. Franceschi, S. Franchini, C. Fuglesang, T. Fujii, J. Fujimoto, M. Fukushima, P. Galeotti, E. García-Ortega, G. Garipov, E. Gascón, J. Genci, G. Giraudo, C. González Alvarado, P. Gorodetzky, R. Greg, F. Guarino, A. Guzmán, Y. Hachisu, M. Haiduc, B. Harlov, A. Haungs, J. Hernández Carretero, W. Hidber Cruz, D. Ikeda, N. Inoue, S. Inoue, F. Isgrò, Y. Itow, T. Jammer, S. Jeong, E. Joven, E.G. Judd, A. Jung, J. Jochum, F. Kajino, T. Kajino, S. Kalli, I. Kaneko, Y. Karadzhov, J. Karczmarczyk, K. Katahira, K. Kawai, Y. Kawasaki, A. Kedadra, H. Khales, B.A. Khrenov, Jeong-Sook Kim, Soon-Wook Kim, M. Kleifges, P.A. Klimov, D. Kolev, H. Krantz, I. Kreykenbohm, K. Kudela, Y. Kurihara, A. Kusenko, E. Kuznetsov, A. La Barbera, C. Lachaud, H. Lahmar, F. Lakhdari, R. Larson, O. Larsson, J. Lee, J. Licandro, L. López Campano, M.C. Maccarone, S. Mackovjak, M. Mahdi, D. Maravilla, L. Marcelli, J.L. Marcos, A. Marini, W. Marszał, K. Martens, Y. Martín, O. Martinez, M. Martucci, G. Masciantonio, K. Mase, M. Mastafa, R. Matev, J.N. Matthews, N. Mebarki, G. Medina-Tanco, M.A. Mendoza, A. Menshikov, A. Merino, J. Meseguer, S.S. Meyer, J. Mimouni, H. Miyamoto, Y. Mizumoto, A. Monaco, J.A. Morales de los Ríos, C. Moretto, S. Nagataki, S. Naitamor, T. Napolitano, W. Naslund, R. Nava, A. Neronov, K. Nomoto, T. Nonaka, T. Ogawa, S. Ogio, H. Ohmori, A.V. Olinto, P. Orleański, G. Osteria, A. Pagliaro, W. Painter, M.I. Panasyuk, B. Panico, G. Pasqualino, E. Parizot, I.H. Park, B. Pastircak, T. Patzak, T. Paul, I. Pérez-Grande, F. Perfetto, T. Peter, P. Picozza, S. Pindado, L.W. Piotrowski, S. Piraino, L. Placidi, Z. Plebaniak, S. Pliego, A. Pollini, Z. Polonski, E.M. Popescu, P. Prat, G. Prévôt, H. Prieto, G. Puehlhofer, M. Putis, J. Rabanal, A.A. Radu, M. Reyes, M. Rezazadeh, M. Ricci, M.D. Rodríguez Frías, M. Rodencal, F. Ronga, G. Roudil, I. Rusinov, M. Rybczyński, M.D. Sabau, G. Sáez Cano, H. Sagawa, Z. Sahnoune, A. Saito, N. Sakaki, H. Salazar, J.C. Sanchez Balanzar, J.L. Sánchez, A. Santangelo, A. Sanz-Andrés, M. Sanz Palomino, O. Saprykin, F. Sarazin, M. Sato, T. Schanz, H. Schieler, V. Scotti, S. Selmane, D. Semikoz, M. Serra, S. Sharakin, H.M. Shimizu, K. Shinozaki, T. Shirahama, B. Spataro, I. Stan, T. Sugiyama, D. Supanitsky, M. Suzuki, B. Szabelska, J. Szabelski, N. Tajima, T. Tajima, Y. Takahashi, H. Takami, M. Takeda, Y. Takizawa, M.C. Talai, C. Tenzer, S.B. Thomas, O. Tibolla, L. Tkachev, H. Tokuno, T. Tomida, N. Tone, S. Toscano, M. Traïche, R. Tsenov, Y. Tsunesada, K. Tsuno, J. Tubbs, S. Turriziani, Y. Uchihori, O. Vaduvescu, J.F. Valdés-Galicia, P. Vallania, G. Vankova, C. Vigorito, L. Villaseñor, B. Vlcek, P. von Ballmoos, M. Vrabel, S. Wada, J. Watanabe, J. Watts Jr., M. Weber, R. Weigand Muñoz, A. Weindl, L. Wiencke, M. Wille, J. Wilms, Z. Włodarczyk, T. Yamamoto, J. Yang, H. Yano, I.V. Yashin, D. Yonetoku, S. Yoshida, R. Young, I.S Zgura, M.Yu. Zotov, A. Zuccaro Marchi, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Organisation de Micro-Électronique Générale Avancée (OMEGA), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de recherche en astrophysique et planétologie (IRAP), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), JEM-EUSO, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abdellaoui, G., Abe, S., Adams, J., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Ave Pernas, M., Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Belz, J. W., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Blecki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., González Alvarado, C., Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Hernández Carretero, J., Hidber Cruz, W., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., López Campano, L., Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J., Marini, A., Marszal, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mustafa, M., Matev, R., Matthews, J., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J. A., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Rodríguez Frías, M. D., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M., Sáez Cano, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez Balanzar, J. C., Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Sanz Palomino, M., Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shin, H. S., Shinozaki, K., Shirahama, T., Sokolsky, P., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Thomson, G. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts, J., Weber, M., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Zuccaro Marchi, A.

Subjects
visible and IR photons, Balloon instrumentation, Detectors for UV, visible and IR photons, Lasers, Space instrumentation, Instrumentation, Mathematical Physics, Laser, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, Fluorescence spectroscopy, law.invention, Aeronáutica, Atmosphere, Xenon, Optics, law, 0103 physical sciences, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Detectors for UV, Physics, Instrumentation et méthodes en physique, 010308 nuclear & particles physics, business.industry, Detector, Autres mathématiques, Speed of light (cellular automaton), 3. Good health, Pathfinder, chemistry, business, Astrophysics - Instrumentation and Methods for Astrophysics, Detectors for UV, visible and IR photon
Abstract

EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25th of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018
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38. Session 1:Colon cancer – 10 years behind the rectum

Author

Søren Laurberg, H. Yano, Gina Brown, V. Tudyka, Anita Wale, and Robert D. Madoff

Subjects
Male, medicine.medical_specialty, Consensus, Time Factors, Colorectal cancer, Rectum, Improved survival, Disease, Risk Assessment, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Colectomy, Rectal Neoplasms, business.industry, General surgery, Gastroenterology, medicine.disease, Quality Improvement, Survival Analysis, Total mesorectal excision, Dissection, medicine.anatomical_structure, Round table, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business, Mesocolon
Abstract

The improvements in surgical technique brought about by the widespread adoption of total mesorectal excision plane dissection in rectal cancer has substantially improved survival and recurrence rates from this disease. For the first time in 50 years, the outcomes in rectal cancer have overtaken those of colon cancer. Professor Madoff's overview lecture and the experts’ round table discussion address whether applying the surgical principles already achieved in rectal cancer can meet with similar success in colon cancer, how this can be achieved and the challenges we face.

Published
2018
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39. SurePath

Author

Y, Naito, A, Kawahara, Y, Okabe, Y, Ishida, E, Sadashima, K, Murata, Y, Takase, H, Abe, T, Yamaguchi, M, Tanigawa, Y, Mihara, R, Kondo, H, Kusano, M, Nakayama, K, Shimamatsu, H, Yano, and J, Akiba

Subjects
Adult, Aged, 80 and over, Cholangiocarcinoma, Cholangiopancreatography, Endoscopic Retrograde, Male, Bile Duct Neoplasms, Cytodiagnosis, Humans, Female, Middle Aged, Aged
Abstract

The current study aimed to compare cytology using SurePathBetween January 2014 and December 2016, 57 patients underwent endoscopic retrograde cholangiopancreatography for the diagnosis of biliary disease. Biliary cytological samples were processed using SP-LBC and subsequently BTH was performed. A final diagnosis was confirmed by surgery (23 malignant cases) and clinical follow-up (34 benign and malignant cases): 18 extrahepatic cholangiocarcinoma; 17 intrahepatic/hilar cholangiocarcinoma (intra/H-CC); eight other malignant disease; and 14 benign biliary disease. The diagnoses made using SP-LBC and BTH were classified into four categories: (1) benign; (2) indeterminate; (3) suspicious for malignancy/malignant; and (4) inadequate. In addition, diagnostic accuracy was compared between SP-LBC and BTH.Although 23% (13/57) of BTH samples were classified as inadequate, all SP-LBC cases were classified as adequate. Among 43 malignant cases, 11 normal, four indeterminate and 28 suspicious for malignancy/malignant were found using SP-LBC (26%, 9% and 65%, respectively), in contrast to 10 inadequate, nine normal, 10 indeterminate and 14 suspicious for malignancy/malignant observed using BTH (23%, 21%, 23%, and 33%, respectively). The identification of malignant cells was strikingly different between SP-LBC and BTH. Furthermore, limited to intra/H-CC, accuracy was significantly higher using SP-LBC than using BTH (P .001).SP-LBC of the biliary tract is a useful and reliable method for diagnosing biliary malignant disease and has an advantage over BTH for detecting malignant cells and accurately diagnosing intra/H-CC.

Published
2018

40. A novel role for SiCN to suppress H2O outgas from TEOS oxide films in hybrid bonding

Author

Masakazu Hamada, Tetsuya Ueda, Yasunori Morinaga, H. Yano, K. Ichinose, M. Tetani, M. Takeuchi, Susumu Matsumoto, S. Uya, and N. Sato

Subjects
Void (astronomy), Materials science, Silicon, Wafer bonding, Annealing (metallurgy), Oxide, chemistry.chemical_element, chemistry.chemical_compound, Outgassing, chemistry, Chemical engineering, Anodic bonding, Wafer, Composite material
Abstract

The novel use of SiCN underneath TEOS oxide as a bonding surface in the wafer bonding of Backside-illuminated (BSI) sensor is proposed and the mechanism of void control by SiCN is clarified. In general, high-temperature processing results in generating voids between the wafer interfaces after bonding due to the release of high-pressure H 2 O contained in TEOS. In the proposed mechanism, the SiCN exposed to high-temperature H 2 O is oxidized thereby preventing the emission of high-pressure H 2 O gas. This paper analyzes the role of SiCN in this mechanism.

Published
2017
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41. EPENDYMOMA

Author

L. M. Hoffman, A. M. Donson, I. Nakachi, A. M. Griesinger, D. K. Birks, V. Amani, M. S. Hemenway, A. K. Liu, M. Wang, T. C. Hankinson, M. H. Handler, N. K. Foreman, M. Zakrzewska, K. Zakrzewski, W. Fendler, L. Stefanczyk, P. P. Liberski, M. Massimino, L. Gandola, P. Ferroli, L. Valentini, V. Biassoni, M. L. Garre, I. Sardi, L. Genitori, C. Giussani, L. Massimi, D. Bertin, A. Mussano, E. Viscardi, P. Modena, A. Mastronuzzi, S. Barra, G. Scarzello, G. Cinalli, P. Peretta, F. Giangaspero, L. Boschetti, E. Schiavello, G. Calareso, M. Antonelli, E. Pecori, F. Di Meco, R. Migliorati, A. Taborelli, H. Witt, M. Sill, K. Wani, S. C. Mack, D. Capper, K. Pajtler, S. Lambert, T. Tzaridis, T. Milde, P. A. Northcott, A. E. Kulozik, O. Witt, V. P. Collins, D. W. Ellison, M. D. Taylor, M. Kool, D. T. W. Jones, A. Korshunov, A. Ken, S. M. Pfister, K. Makino, H. Nakamura, J.-i. Kuroda, J.-i. Kuratsu, H. Toledano, Y. Margolin, A. Ohali, S. Michowiz, P. Johann, U. Tabori, E. Walker, C. Hawkins, M. Taylor, I. Yaniv, S. Avigad, L. Hoffman, S. R. Plimpton, N. V. Stence, R. Vibhakar, A. Lourdusamy, R. Rahman, J. Ward, H. Rogers, R. Grundy, C. Punchihewa, R. Lee, T. Lin, W. Orisme, J. Dalton, E. Aronica, A. Smith, A. Gajjar, A. Onar, S. Pounds, R. Tatevossian, T. Merchant, D. Ellison, M. Parker, K. Mohankumar, R. Weinlich, T. Phoenix, R. Thiruvenkatam, E. White, K. Gupta, F. Boop, L. Ding, E. Mardis, R. Wilson, J. Downing, R. Gilbertson, D. Speed, T. Gould, t. I. E. Consortium, A. Griesinger, A. Donson, D. Birks, N. Ohe, H. Yano, N. Nakayama, T. Iwama, K. Wright, T. Hassall, D. C. Bowers, J. Crawford, A. Bendel, P. G. Fisher, P. Klimo, G. Armstrong, I. Qaddoumi, G. Robinson, C. Wetmore, A. Broniscer, R. Chapman, C. Mayne, H. Duane, J.-P. Kilday, B. Coyle, A. Graul-Conroy, W. Hartsell, T. Bragg, S. Goldman, S. Rebsamen, D. Puccetti, S. Salamat, N. J. Patel, A. Gomi, H. Oguma, T. Hayase, Y. Kawahara, M. Yagi, A. Morimoto, C. Wilbur, C. Dunham, D. Mabbott, A.-S. Carret, L. Lafay-Cousin, P. D. McNeely, D. Eisenstat, B. Wilson, D. Johnston, J. Hukin, M. Mynarek, R. D. Kortmann, P. Kaatsch, T. Pietsch, B. Timmermann, G. Fleischhack, M. Benesch, C. Friedrich, A. O. von Bueren, N. U. Gerber, K. Muller, S. Tippelt, M. Warmuth-Metz, S. Rutkowski, K. von Hoff, M. K. Murugesan, H. Poppleton, S. Currle, T. Kranenburg, C. Eden, N. Boulos, J. Dapper, Y. Patel, B. Freeman, A. Shelat, C. Stewart, R. Guy, J. Adamski, A. Huang, U. Bartels, V. Ramaswamy, R. Krishnatry, N. Laperriere, E. Bouffet, A. Araki, M. Chocholous, J. Gojo, C. Dorfer, T. Czech, K. Dieckmann, I. Slavc, C. Haberler, E. Doerner, A. z. Muehlen, R. Kortmann, A. von Buehren, H. Ottensmeier, A. Resch, R. Kwiecien, A. Faldum, J. Kuehl, D. Sabnis, L. Storer, L. Simmonds, S. Blackburn, J. Lowe, I. Kerr, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, S. Rahmann, L. Klein-Hitpass, M. J. L. Iglesias, F. G. Riet, F. D. Dhermain, S. Canale, C. Dufour, C. S. Rose, S. Puget, J. Grill, S. Bolle, J. Parkes, A. Davidson, A. Figaji, K. Pillay, T. Kilborn, L. Padayachy, M. Hendricks, A. Van Eyssen, E. Piccinin, E. Lorenzetto, M. Brenca, K. Aldape, Y.-J. Cho, W. Weiss, J. Phillips, N. Jabado, J. Mora, X. Fan, S. Jung, J. Y. Lee, K. Zitterbart, P. French, J. M. Kros, P. Hauser, C. Faria, and S. Pfister

Subjects
Abstracts, Cancer Research, Tumor grade, Oncology, Expression pattern, business.industry, microRNA, Cancer research, Medicine, Neurology (clinical), business
Published
2014
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45. Production of Cellulose Nanofibres and Their Applications

Author

H Yano

Subjects
chemistry.chemical_compound, Materials science, Polymers and Plastics, Chemical engineering, chemistry, Production (economics), 02 engineering and technology, Cellulose, 010402 general chemistry, 021001 nanoscience & nanotechnology, 0210 nano-technology, 01 natural sciences, 0104 chemical sciences
Published
2013
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46. NEUROSURGERY

Author

J. Ibanez, M. Brell, M. Tomas, P. Roldan, M. Guibelalde, A. Tavera, J. A. Salinas, T. Suzuki, K. Fukuoka, T. Kohga, T. Yanagisawa, J. Adachi, K. Mishima, T. Fujimaki, M. Matsutani, S. Ishihara, R. Nishikawa, R. Keating, T. DeFreitas, F. Al Abbas, J. Myseros, A. Yaun, S. Magge, B. Pettorini, R. Al-Mahfoudh, J. Yousaf, B. Pizer, M. Jenkinson, C. Mallucci, S. Parlato, R. Kumar, S. Avula, M. Munoz, H. Yano, N. Ohe, N. Nakayama, J. Shinoda, T. Iwama, C. Rahman, S. Smith, P. Morgan, K. Langmack, D. Macarthur, F. Rose, K. Shakesheff, R. Grundy, R. Rahman, M. Krieger, S. J. Si, N. Flores, K. Haley, J. Malvar, R. Sposto, J. Fangusaro, G. Dhall, T. B. Davidson, J. Finlay, V. Caretti, T. Lagerweij, P. Schellen, M. Jansen, D. G. van Vuurden, E. Hulleman, S. Idema, W. P. Vandertop, D. P. Noske, G. Kaspers, T. Wurdinger, N. Luther, Z. Zhou, P. Zanzonico, N.-K. Cheung, M. Souweidane, R. Kotecha, E. Pascoe, E. Rushing, L. Rorke-Adams, T. Zwerdling, X. Gao, X. Li, S. Greene, A. Amirjamshidi, S.-K. Kim, M. Lima, P.-C. Hung, F. Lakhdar, N. Mehta, Y. Liu, B. I. Devi, B. J. Sudhir, M. Lund-Johansen, F. Gjerris, C. Cole, N. Gottardo, C. Dorfer, I. Slavc, K. Dieckmann, K. Gruber, M. Schmook, T. Czech, A. Griffin, J. Greenfield, R. R. Lulla, V. Rao, A. Haridas, M. Ryan, J. L. Goldstein, M. Wainwright, and T. Tomita

Subjects
Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published
2012
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47. Cyclic deformation behavior and low cycle fatigue life of normalized medium carbon steel with hydrogen charging

Author

H. Yano, Y. Tsuchida, G. Suzuki, and T. Watanabe

Subjects
Materials science, Carbon steel, Hydrogen, Metallurgy, chemistry.chemical_element, Ferrite, Fracture mechanics, vacancy, General Medicine, Strain controlled low cycle fatigue, engineering.material, Fatigue limit, Crack closure, Cracking, chemistry, Ferrite (iron), engineering, Fatigue life, dislocation, Composite material, Pearlite, Engineering(all)
Abstract

The effects of hydrogen on low cycle fatigue properties have been fundamentally examined using normalized JIS S45C steel. With the aid of hydrogen thermal desorption analysis, the influence of the increase in carbon content has been discussed. The S45C steel easily pick-up hydrogen. But it is relatively insensitive to hydrogen absorption. This increased amount of hydrogen pick-up is firstly caused by large amount of pearlite structure. Further sulfur takes an important role for hydrogen pick up during cathodic charging. Hydrogen plays two kinds of roles during fatigue tests. One is hydrogen in dislocation core and makes plastic deformation easier in the first monotonic tension stage. The other is hydrogen/vacancy pair, and suppresses dislocation motion and increases stress amplitudes. The latter should be the fundamental issue for fatigue life. The amount of absorbed hydrogen itself is not only important, but the difference of hydrogen concentration between surface and inside is more important. When the fatigue crack initiates inside, the fatigue life is severely damaged to less than 10% of non-charged one. Taking the lower limit value of hydrogen to form internal fish-eye type cracking, S45C is less sensitive to hydrogen in cyclic straining. This comes from the pearlite structure that resists crack propagation.

Published
2011
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49. Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal mesothelioma

Author

E.M. Murphy, B. J. Moran, Tom Cecil, and H. Yano

Subjects
Adult, Male, Mesothelioma, Abdominal pain, medicine.medical_specialty, Exploratory laparotomy, medicine.medical_treatment, Postoperative Complications, Antineoplastic Combined Chemotherapy Protocols, Ascites, Humans, Medicine, Infusions, Parenteral, Prospective Studies, Prospective cohort study, Peritoneal Neoplasms, Aged, business.industry, Patient Selection, General surgery, General Medicine, Middle Aged, Abdominal distension, medicine.disease, Debulking, Combined Modality Therapy, Survival Analysis, Pulmonary embolism, Surgery, Oncology, Peritoneal mesothelioma, Female, medicine.symptom, business
Abstract

Aims Peritoneal mesothelioma is a rare disease and traditionally has been associated with a gloomy prognosis. The present study aimed to report the outcomes following surgery and intraperitoneal chemotherapy in selected patients with peritoneal mesothelioma. Methods Clinicopathological features, operative procedures, early outcomes and survival were analysed for 17 consecutive patients who underwent surgery for peritoneal mesothelioma between 1998 and 2007. Seventeen consecutive patients who underwent surgery for peritoneal mesothelioma between 1998 and 2007 were analysed for clinicopathological features, operative procedures, early outcomes and survival. Results Seventeen patients underwent 18 laparotomies. Most presented with abdominal distension (71%) and abdominal pain or discomfort (53%). Complete cytoreduction was achieved in 8 patients, major debulking in 8, and 1 patient had an exploratory laparotomy only due to extensive disease. One patient died on day 30 postoperatively due to a chest infection and pulmonary embolism. The median survival for 8 patients who underwent complete cytoreduction was 3.7 years (range, 0.7–6.9), whereas that for 8 patients with palliative debulking was 1.0 years year (range, 0.3–5.7). Among the 12 patients who had significant ascites as a presenting symptom, 10 reported good palliation of ascites. Conclusions Cytoreductive surgery combined with intraperitoneal chemotherapy appears to be the optimal treatment for selected patients with peritoneal mesothelioma. Increased familiarity with this condition's presentation and natural history, and knowledge of available treatment options, will hopefully facilitate treatment of these patients and expedite speedy referral to appropriate treatment centres.

Published
2009
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