58 results on '"Hachidai Takahashi"'
Search Results
2. Impact of CD14++CD16+ monocytes on plaque vulnerability in diabetic and non-diabetic patients with asymptomatic coronary artery disease: a cross-sectional study
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Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, and Ken-ichi Hirata
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CD14++CD16+ monocytes ,Coronary plaque vulnerability ,Thin-cap fibroatheroma ,Glucose fluctuations ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14++CD16+ monocytes on plaque vulnerability, as assessed by virtual histology intravascular ultrasound (VH-IVUS), as well as their relationship to fluctuating glucose levels in patients with asymptomatic coronary artery disease (CAD). Methods Fifty-one patients with asymptomatic CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS evaluation for angiographically mild to moderate lesions, were enrolled in the study. Standard VH-IVUS parameters, including the percentage volume of the necrotic core (%NC) within the plaque and the presence of a virtual histology thin-cap fibroatheroma (VH-TCFA), were then evaluated. Additionally, monocyte subsets were assessed by flow cytometry, and daily glucose fluctuations were analyzed by measuring the mean amplitude of glycemic excursion (MAGE). Results Among 82 plaques from 22 diabetes mellitus (DM) patients and 29 non-DM patients, 15 VH-TCFAs were identified. CD14++CD16+ monocyte counts significantly correlated with both %NC and the presence of VH-TCFA (%NC: r = 0.339, p = 0.002; VH-TCFA: p = 0.003). Multivariate logistic regression analysis revealed that CD14++CD16+ monocyte counts were independently associated with VH-TCFA (odds ratio = 1.029, p = 0.004). Furthermore, CD14++CD16+ monocyte counts were significantly correlated with the MAGE score in the non-DM patients (r = 0.544, p = 0.005). Conclusions CD14++CD16+ monocyte levels are associated with coronary plaque vulnerability and can serve as a biomarker for VH-TCFA in patients with CAD undergoing lipid-lowering therapy. In patients without DM, glucose fluctuations may alter the balance of monocyte subsets. Trial registration UMIN Registry number: UMIN000021228
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- 2017
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3. ViperSlide-Induced Anaphylaxis: A Cautionary Complication During Orbital Atherectomy
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Hiroyuki, Yamamoto, Tomofumi, Takaya, Takahiro, Sawada, Hachidai, Takahashi, and Hiroya, Kawai
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Atherectomy, Coronary ,Atherectomy ,Percutaneous Coronary Intervention ,Treatment Outcome ,Humans ,Coronary Artery Disease ,Coronary Angiography ,Vascular Calcification ,Anaphylaxis ,Severity of Illness Index ,Retrospective Studies - Published
- 2022
4. ViperSlide-Induced Anaphylaxis
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Hiroyuki Yamamoto, Tomofumi Takaya, Takahiro Sawada, Hachidai Takahashi, and Hiroya Kawai
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Cardiology and Cardiovascular Medicine - Published
- 2022
5. Acute Adrenal Insufficiency Precipitated by the Discontinuation of a Betamethasone and Dextrochlorpheniramine Combination: The Diagnostic Utility of an Echocardiographic Assessment of Systemic Vascular Resistance
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Ken-ichi Hirata, Ryo Takeshige, Hiroyuki Shimoura, Hiroshi Imada, Jun Mukai, Shumpei Mori, Yutaka Takahashi, Tokiko Tabata, Hachidai Takahashi, and Yukiko Katsumori-Yoshimura
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medicine.medical_specialty ,Chlorpheniramine ,Hydrocortisone ,Perforation (oil well) ,systemic vascular resistance ,Shock, Cardiogenic ,Case Report ,030204 cardiovascular system & hematology ,betamethasone ,Medication Adherence ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,medicine ,Adrenal insufficiency ,Humans ,Aged ,Heart Failure ,Ejection fraction ,business.industry ,primary biliary cholangitis ,Cardiogenic shock ,Hemodynamics ,General Medicine ,medicine.disease ,acute adrenal insufficiency ,Discontinuation ,celestamine ,medicine.anatomical_structure ,Treatment Outcome ,Echocardiography ,Heart failure ,Cardiology ,Vascular resistance ,Betamethasone ,030211 gastroenterology & hepatology ,Female ,Vascular Resistance ,business ,medicine.drug ,Adrenal Insufficiency - Abstract
A 72-year-old woman with primary biliary cholangitis was admitted to our hospital with heart failure with a preserved ejection fraction. An accidental right ventricular perforation that occurred during an endomyocardial biopsy precipitated cardiogenic shock. Despite successful surgical treatment, she demonstrated progressive hemodynamic deterioration, which was resistant to the administration of high-dose catecholamines. She was diagnosed with acute adrenal insufficiency, which was attributed to the discontinuation of Celestamine® (betamethasone/dextrochlorpheniramine combination) just after the perforation. Prompt intravenous administration of hydrocortisone (150 mg/day) led to hemodynamic stabilization. The serial noninvasive assessment of systemic vascular resistance using transthoracic echocardiography was instrumental in detecting acute adrenal insufficiency in this case.
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- 2019
6. Peri-strut low-intensity area assessed by midterm follow-up optical coherence tomography may predict target lesion revascularisation after everolimus-eluting stent implantation
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Yuichiro Nagano, Koji Kuroda, Takayoshi Toba, Daiji Kashiwagi, Daisuke Terashita, Hachidai Takahashi, Masaru Kuroda, Ken-ichi Hirata, Toshiro Shinke, Hiromasa Otake, Yoshinori Nagasawa, and Kenzo Uzu
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Target lesion ,Neointima ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Everolimus ,030212 general & internal medicine ,Risk factor ,Sirolimus ,business.industry ,Incidence (epidemiology) ,Hazard ratio ,Stent ,Drug-Eluting Stents ,Coronary Vessels ,Treatment Outcome ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Optical Coherence ,Follow-Up Studies ,medicine.drug - Abstract
AIMS Peri-strut low-intensity area (PLIA) assessed by optical coherence tomography (OCT) has been reported as a potential marker of abnormal neointimal healing. We aimed to evaluate the impact of PLIA on clinical events and its risk factors. METHODS AND RESULTS We enrolled 264 consecutive patients treated with an everolimus-eluting stent (EES) who underwent follow-up OCT six to 12 months after stenting. Target lesion revascularisation (TLR) was evaluated at a mean 42.6 months after stenting. PLIA was identified in 102 patients; 162 patients did not exhibit PLIA. Multivariate Cox hazard regression analysis indicated that the presence of PLIA (PLIA+) was an independent risk factor for an increased incidence of TLR (hazard ratio [HR]: 4.608, p=0.003). In both the early ( 1 year) phases, the incidence of TLR was significantly higher in the PLIA+ group (p
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- 2019
7. Favorable early vessel healing after everolimus-eluting stent implantation: 3-, 6-, and 12-month follow-up of optical coherence tomography
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Tomofumi Takaya, Ryo Nishio, Toshiro Shinke, Tsuyoshi Osue, Hiromasa Otake, Hiroto Kinutani, Hachidai Takahashi, Akihide Konishi, Junya Shite, Daisuke Terashita, Masaru Kuroda, Masamichi Iwasaki, and Ken-ichi Hirata
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Male ,Neointima ,medicine.medical_specialty ,Everolimus eluting stent ,medicine.medical_treatment ,Lumen (anatomy) ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Optical coherence tomography ,Internal medicine ,medicine ,Humans ,Everolimus ,Postoperative Period ,Prospective Studies ,030212 general & internal medicine ,Aged ,Randomized Controlled Trials as Topic ,Heart Valve Prosthesis Implantation ,Neointimal hyperplasia ,Wound Healing ,Hyperplasia ,medicine.diagnostic_test ,business.industry ,Stent ,Drug-Eluting Stents ,Middle Aged ,medicine.disease ,Coronary Vessels ,Treatment Outcome ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Early phase ,Tomography, Optical Coherence ,Follow-Up Studies ,Month follow up - Abstract
Background Although a prospective randomized control study revealed that 3-month dual anti-platelet therapy (DAPT) is safe and does not compromise the efficacy of everolimus-eluting stent (EES) in selected patients, detailed vessel healing at early phase after EES implantation has yet to be investigated in Japanese patients. Methods and results A total of 27 lesions in 19 patients treated with EES were serially evaluated by using optical coherence tomography (OCT) at 3, 6, and 12 months after stent implantation. In addition to standard quantitative OCT parameters, the percentage of stents with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (63 ± 17 μm; 83 ± 30 μm; and 111 ± 44 μm, respectively; p = 0.006) and small decrease in average lumen area (6.80 ± 2.57 mm2, 6.62 ± 2.58 mm2, 6.33 ± 2.58 mm2, p = 0.038) from the 3- to the 12-month follow-up. The incidences of uncovered and malapposed struts were low at 3 months and did not significantly change at 6 months and 12 months (3.01 ± 4.43; 2.45 ± 3.75; and 1.47 ± 3.16, p = 0.143, and 0.75 ± 0.65; 0.63 ± 0.73; and 0.58 ± 1.42, p = 0.162, respectively). Also, frequency of struts with PLIA was already low at three months and significantly decreased during the follow-up (6.4 ± 6.5; 4.6 ± 5.4; and 2.3 ± 3.3, respectively; p = 0.001). Conclusion Favorable vessel healing was achieved at 3 months after EES implantation without neointimal hyperplasia which was persistently suppressed up to 12 months.
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- 2018
8. Quetiapine-related Acute Kidney Injury Requiring Transient Continuous Hemodiafiltration
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Yukiko Katsumori, Miki Kawano, Yutaka Okita, Hiroyuki Shimoura, Haruhi Yamada, Jun Mukai, Hiroshi Imada, Ryo Takeshige, Ken-ichi Hirata, Shumpei Mori, Tadasu Horai, and Hachidai Takahashi
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Male ,medicine.drug_class ,030232 urology & nephrology ,Atypical antipsychotic ,Case Report ,Hemodiafiltration ,Quetiapine Fumarate ,03 medical and health sciences ,0302 clinical medicine ,Internal Medicine ,medicine ,Humans ,030212 general & internal medicine ,atypical antipsychotic drug ,Acute tubular necrosis ,Aged ,business.industry ,continuous hemodiafiltration ,Acute kidney injury ,General Medicine ,quetiapine ,medicine.disease ,Discontinuation ,acute kidney injury ,acute tubular necrosis ,Anesthesia ,Heart failure ,Delirium ,Quetiapine ,medicine.symptom ,business ,Antipsychotic Agents ,medicine.drug - Abstract
A 73-year-old man, with congestive heart failure due to combined valvar disease, underwent curative surgery. Although the surgery was successful, his clinical course was eventful because of pulmonary complications, and he began to deteriorate mentally. Quetiapine was prescribed, which appeared to effectively settle his mental status. Following the administration of quetiapine, however, he developed acute kidney injury (AKI) that required continuous hemodiafiltration. Subsequent to discontinuation of quetiapine, his renal function gradually improved. Atypical antipsychotic drugs, including quetiapine, are frequently used to treat delirium in elderly patients in the intensive-care setting. This case highlights a potential risk of quetiapine-related AKI.
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- 2018
9. Data on impact of monocytes and glucose fluctuation on plaque vulnerability in patients with coronary artery disease
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Kenzo Uzu, Wataru Ogawa, Kenichi Yanaka, Hachidai Takahashi, Takuo Emoto, Natsuko Tahara, Takayoshi Toba, Naoto Sasaki, Hiromasa Otake, Yuichiro Nagano, Naofumi Yoshida, Hiroyuki Yamamoto, Daisuke Terashita, Yushi Hirota, Masaru Kuroda, Kouji Kuroda, Yuto Shinkura, Yoshiro Tsukiyama, Yoshinori Nagasawa, Ken-ichi Hirata, Kazuhiko Sakaguchi, Tomoya Yamashita, and Toshiro Shinke
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0301 basic medicine ,medicine.medical_specialty ,Multidisciplinary ,business.industry ,CD14 ,030204 cardiovascular system & hematology ,CD16 ,Medicine and Dentistry ,lcsh:Computer applications to medicine. Medical informatics ,medicine.disease ,Coronary artery disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Internal medicine ,Coronary plaque ,medicine ,Cardiology ,lcsh:R858-859.7 ,Population study ,Research article ,In patient ,lcsh:Science (General) ,business ,lcsh:Q1-390 - Abstract
Data presented in this article are supplementary material to our research article entitled “Impact of CD14++CD16+ monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients” [1]. This article contains the data of study population, diagnostic ability of CD14++CD16+ monocytes to identify thin-cap fibroatheromas, and association between laboratory variables and plaque properties.
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- 2018
10. Impact of CD14 ++ CD16 + monocytes on coronary plaque vulnerability assessed by optical coherence tomography in coronary artery disease patients
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Wataru Ogawa, Takayoshi Toba, Tomoya Yamashita, Kenichi Yanaka, Kazuhiko Sakaguchi, Kenzo Uzu, Yuichiro Nagano, Toshiro Shinke, Hiromasa Otake, Natsuko Tahara, Naofumi Yoshida, Yoshinori Nagasawa, Hachidai Takahashi, Hiroyuki Yamamoto, Yushi Hirota, Daisuke Terashita, Masaru Kuroda, Takuo Emoto, Kouji Kuroda, Yuto Shinkura, Naoto Sasaki, Ken-ichi Hirata, and Yoshiro Tsukiyama
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0301 basic medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,CD14 ,Monocyte ,Fibrous cap ,030204 cardiovascular system & hematology ,CD16 ,medicine.disease ,Coronary artery disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Optical coherence tomography ,Internal medicine ,Diabetes mellitus ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Glycemic - Abstract
Background and aims This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. Methods This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14++CD16+ monocyte percentages assessed by flow cytometry. Standard OCT parameters were assessed for 97 angiographically intermediate lesions (diameter stenosis: 30–70%). Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). Results CD14++CD16+ monocytes negatively correlated with fibrous cap thickness (r = −0.508, p Conclusions CD14++CD16+ monocytes were associated with coronary plaque vulnerability in CAD patients with well-regulated lipid levels both in DM and non-DM patients. Cross-talk between glucose fluctuation and CD14++CD16+ monocytes may enhance plaque vulnerability, particularly in non-DM patients. CD14++CD16+ monocytes could be a possible therapeutic target for coronary plaque stabilization.
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- 2018
11. Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial)
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Yoshihiro Morino, Tetsuya Ioji, Ken Kozuma, Hiromasa Otake, Tetsuya Fusazaki, Hachidai Takahashi, Hideaki Kaneda, Opinion Investigators, Toshiro Shinke, Kiyoshi Hibi, Takashi Akasaka, Takashi Kubo, Gaku Nakazawa, Takayuki Okamura, and Junya Shite
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Lumen (anatomy) ,Percutaneous coronary intervention ,Stent ,030204 cardiovascular system & hematology ,equipment and supplies ,Domain imaging ,03 medical and health sciences ,surgical procedures, operative ,0302 clinical medicine ,Optical coherence tomography ,Optical frequencies ,Intravascular ultrasound ,Conventional PCI ,medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The authors sought to clarify how intravascular ultrasound (IVUS) and optical coherence tomography affect percutaneous coronary intervention (PCI) with current-generation drug-eluting stents in a pre-specified substudy of the OPINION (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON) trial, a multicenter, prospective, randomized, noninferiority trial comparing optical frequency domain imaging (OFDI)-guided PCI with IVUS-guided PCI. Background The impact of these 2 imaging modalities in guiding PCI remains unknown. Methods Of 829 patients enrolled in the OPINION trial, 106 were included in the present imaging substudy. Their PCI was guided by either IVUS or OFDI, but all patients were imaged by both modalities after PCI and by OFDI at 8 months. Angiographic, OFDI, and IVUS images were analyzed by independent core laboratories, and statistical analysis was done independently by a dedicated institution. Results A total of 103 patients underwent either OFDI-guided (n = 54) or IVUS-guided (n = 49) PCI. Immediately after PCI, OFDI-guided PCI was associated with a smaller trend of minimum stent area (5.28 ± 1.65 mm2 vs. 6.12 ± 2.34 mm2; p = 0.088), fewer proximal stent-edge hematomas (p = 0.04), and fewer irregular protrusions (p = 0.014) than IVUS-guided PCI. At 8 months, the neointima area tended to be smaller in the OFDI-guided PCI group than in the IVUS-guided PCI group (0.56 ± 0.30 mm2 vs. 0.80 ± 0.65 mm2; p = 0.057), although the percentage of uncovered struts was significantly higher in the OFDI-guided PCI group than in the IVUS-guided PCI group (6.97 ± 7.03% vs. 4.67 ± 6.43%; p = 0.039). The minimum lumen area was comparable in both groups (p = 0.18). Conclusions There were several differences in local findings between OFDI- and IVUS-guided PCI as expected given the different protocols for stent sizing in the 2 groups. The minimum lumen area at the 8-month follow-up was comparable, suggesting that OFDI- and IVUS-guided PCI are similarly feasible using the current-generation drug-eluting stents. (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON; NCT01873222 )
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- 2018
12. Morphological and pharmacological determinants of peri-procedural myocardial infarction following elective stent implantation: Optical coherence tomography sub-analysis of the PRASFIT-Elective study
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Akihide Konishi, Ken-ichi Hirata, Hachidai Takahashi, Kenzo Uzu, Daisuke Terashita, Tsuyoshi Osue, Shigeru Saito, Takashi Akasaka, Junya Shite, Masato Nakamura, Hiromasa Otake, Toshiro Shinke, Masaru Kuroda, Tomofumi Takaya, Hiroto Kinutani, and Masamichi Iwasaki
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Male ,medicine.medical_specialty ,Ticlopidine ,Prasugrel ,medicine.medical_treatment ,Myocardial Infarction ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Double-Blind Method ,Internal medicine ,Creatine Kinase, MB Form ,Humans ,Medicine ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Thrombus ,Aged ,Aspirin ,business.industry ,Percutaneous coronary intervention ,Stent ,Thrombosis ,Middle Aged ,medicine.disease ,Clopidogrel ,surgical procedures, operative ,Elective Surgical Procedures ,Conventional PCI ,Cardiology ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Prasugrel Hydrochloride ,Platelet Aggregation Inhibitors ,Tomography, Optical Coherence ,medicine.drug - Abstract
Background Previous studies have suggested that peri-procedural myocardial infarction (PMI) following percutaneous coronary intervention (PCI) is associated with adverse short- and long-term outcomes, and several morphological predictors of PMI have been studied. However, the determinants of PMI under novel anti-platelet therapy are not fully elucidated. Methods and results PRASFIT-Elective is a multicenter, parallel-group study of PCI patients in non-acute settings receiving either prasugrel or clopidogrel in addition to aspirin. Among 742 study patients, 94 (116 lesions) underwent optical coherence tomography (OCT) to evaluate the area of intra-stent tissue (IST, which comprises tissue protrusion and thrombus) after stenting in addition to standard parameters. We investigated the relationship between the peak creatine kinase (CK)-MB fraction levels after PCI and post-stent OCT findings, as well as on-treatment platelet reactivity determined by the P2Y12 reaction units (PRU) at PCI, in a post hoc manner. The multivariate linear analysis revealed that a larger total IST area (standardized coefficient: 0.370, p Conclusion Following elective PCI, a large IST area originating from a lipid-rich plaque and a smaller minimal stent diameter were associated with PMI.
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- 2017
13. The impact of serum trans fatty acids concentration on plaque vulnerability in patients with coronary artery disease: Assessment via optical coherence tomography
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Daisuke Terashita, Yuichiro Nagano, Hachidai Takahashi, Hiroyuki Yamamoto, Ken-ichi Hirata, Kenichi Yanaka, Ryuji Toh, Koji Kuroda, Takayosi Toba, Kenzo Uzu, Hiromasa Otake, Natsuko Tahara, Daisuke Sugiyama, Masaru Kuroda, Yoshinori Nagasawa, Daiji Kashiwagi, Toshiro Shinke, Tomofumi Takaya, Yuto Shinkura, Tatsuro Ishida, and Yoshiro Tsukiyama
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Male ,Thin-cap fibroatheroma ,medicine.medical_specialty ,Oleic Acids ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Gastroenterology ,Lesion ,Coronary artery disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Risk factor ,Aged ,medicine.diagnostic_test ,Optical coherence tomography ,business.industry ,Cholesterol ,Trans Fatty Acids ,medicine.disease ,Elaidic acid ,Plaque, Atherosclerotic ,Surgery ,Residual risk ,Stenosis ,Cross-Sectional Studies ,chemistry ,Female ,Trans fatty acid ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Lipid profile ,Tomography, Optical Coherence ,Oleic Acid - Abstract
Background and aims: Recent epidemiological studies have showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management, including statins. This study aimed at investigating the association between lipid profile, including serum TFA concentration, and plaque vulnerability using optical coherence tomography (OCT). Methods: The level of serum elaidic acid, a major TFA component, was measured using gas chromatography in 161 consecutively enrolled patients with CAD under guideline-directed risk factor management. OCT was performed to evaluate morphological features of angiographic intermediate stenosis (30% < diameter of stenosis < 70%). OCT data were also used to measure lipid index (LI), defined as mean lipid arc multiplied by lipid length, and determine the presence of thin-cap fibroatheroma (TCFA), defined as a lipid-rich plaque with the smallest fibrous cap thickness < 65 μm and the maximal arc > 90. Results: Among 190 lesions assessed using OCT, 49 TCFAs were detected. In patients with at least one TCFA lesion, levels of elaidic acid (12.9 ± 4.9 vs. 10.3 ± 4.3 μmol/L, p = 0.001), triglycerides (169 ± 81 vs. 130 ± 60 mg/dL, p = 0.005), and remnant-like particle cholesterol (10.4 ± 6.5 vs. 7.7 ± 4.7 mg/dL, p = 0.005) were higher than in those without TCFAs. Generalized estimating equations identified elaidic acid level as the independent risk factor of TCFA. LI had a positive correlation with elaidic acid level (r = 0.173, p = 0.025). Conclusions: TFA may affect plaque vulnerability in patients with CAD. Serum TFA concentration may represent another cardiovascular risk factor during conventional risk factor management.
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- 2017
14. Impact of Diabetes Mellitus on Intravascular Ultrasound-Guided Provisional Stenting in Coronary Bifurcation Lesions J-REVERSE Sub-Study
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Shinichiro Yamada, Kenichi Fujii, Masahiro Yamawaki, Yoshihisa Kinoshita, Yoshihiro Takeda, Hachidai Takahashi, Yoshihisa Shimada, Daisuke Terashita, Yoshinobu Murasato, and Toshiro Shinke
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Stent ,030204 cardiovascular system & hematology ,medicine.disease ,Vessel diameter ,03 medical and health sciences ,0302 clinical medicine ,Main vessel ,Side branch ,Diabetes mellitus ,Internal medicine ,Intravascular ultrasound ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Radiology ,Thrombus ,Cardiology and Cardiovascular Medicine ,business ,Coronary bifurcation - Abstract
Objective To investigate the impact of diabetes mellitus (DM) on provisional coronary bifurcation stenting under the complete guidance of intravascular-ultrasound (IVUS). Background The efficacy of such intervention has not yet been fully elucidated in the DM patients. Methods A total of 100 DM and 139 non-DM patients in a prospective multi-center registry of IVUS-guided bifurcation stenting were compared in angiographic results at 9 months. Vessel and luminal changes during the intervention were analyzed using the IVUS. Vascular healing at the follow-up was also investigated in 23 lesions in each group using optical coherence tomography (OCT). Results No difference was detected regarding baseline reference vessel diameter and minimum lumen diameter in proximal main vessel (MV), distal MV, and side branch (SB). The rate of everolimus-eluting stent use (78.4% vs. 78.3%), final kissing inflation (60.1% vs. 49.0%), and conversion to 2-stent strategy (2.9% vs. 2.8%) were also similar. In the DM group, late loss was greater in proximal MV (DM 0.23 ± 0.29 vs. non-DM 0.16 ± 0.24 mm, P
- Published
- 2016
15. Serial Optical Coherence Tomography Evaluation at 6, 12, and 24 Months After Biolimus A9-Eluting Biodegradable Polymer-Coated Stent Implantation
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Akihide Konishi, Hachidai Takahashi, Tomofumi Takaya, Daisuke Terashita, Hiroto Kinutani, Junya Shite, Masaru Kuroda, Tsuyoshi Osue, Toshiro Shinke, Ken-ichi Hirata, and Hiromasa Otake
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Male ,Coronary angiography ,Neointima ,medicine.medical_specialty ,Time Factors ,Polymers ,Fibrin deposition ,medicine.medical_treatment ,Coronary Artery Disease ,Coronary Angiography ,Prosthesis Design ,Coated Materials, Biocompatible ,Optical coherence tomography ,medicine ,Humans ,Stent implantation ,Prospective Studies ,Aged ,Sirolimus ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Stent ,Drug-Eluting Stents ,Coronary Vessels ,Biodegradable polymer ,Surgery ,Treatment Outcome ,cardiovascular system ,Female ,Gradual increase ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
Background The Nobori (Terumo Corporation, Tokyo, Japan) is a biolimus A9-eluting stent (BES) featured with a biodegradable polymer coated on the abluminal side only. We previously reported that favourable vessel healing was achieved at 6-12 months after BES implantation. However, detailed long-term vessel reaction after BES deployment is unclear. Methods Twenty-two BESs were serially evaluated using optical coherence tomography (OCT) at 6, 12, and 24 months after stenting. Average neointimal thickness, uncovered struts, and neointimal unevenness score (each cross-section as maximum neointimal thickness in 1 cross section divided by the average neointimal thickness of the same cross-section) were manually measured. In addition, we evaluated the percentage of struts with peri-strut low-intensity area (a region around stent struts that homogenously showed less intensity than the surrounding tissue, which suggests fibrin deposition or impaired neointima maturation), thrombi, and atherogenic neointimas (neointimas containing a diffuse border and poor-signal region with invisible struts due to marked signal attenuation). Results Serial OCT observation revealed a small gradual increase in neointimal thickness from 6 to 24 months (73 ± 24 μm; 81 ± 26 μm; and 108 ± 35 μm, respectively, P = 0.001) with a nonsignificant decrease in the lumen area (6.36 ± 1.98 mm 2 ; 6.18 ± 2.04 mm 2 ; and 5.87 ± 2.06 mm 2 ; P = 0.72). Frequency of uncovered struts (3.89 ± 3.91%; 1.55 ± 1.63%; and 0.23 ± 0.67%; P = 0.001), neointimal unevenness score (1.95 ± 0.18% to 1.86 ± 0.19% to 1.78 ± 0.17; P = 0.012), percentage of thrombi (5%, 0%, and 0%; P = 0.37) and peri-strut low-intensity area (6.8%, 5.1%, and 1.6%; P = 0.017) decreased from 6 to 12 and 24 months. Atherogenic neointima was not observed in the event-free OCT cohort. Conclusions The Nobori stent achieved acceptable long-term vessel healing, mostly without adverse vessel reactions.
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- 2015
16. Effect of Daily Glucose Fluctuation on Coronary Plaque Vulnerability in Patients Pre-Treated With Lipid-Lowering Therapy
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Kazuhiko Sakaguchi, Toshiro Shinke, Yushi Hirota, Daisuke Terashita, Yu Taniguchi, Masamichi Iwasaki, Noritoshi Hiranuma, Hiromasa Otake, Ken-ichi Hirata, Hiroto Kinutani, Hirotoshi Hariki, Tsuyoshi Osue, Masaru Kuroda, Hachidai Takahashi, Daisuke Sugiyama, Masayuki Nakagawa, Tomofumi Takaya, Ryo Nishio, Takeshi Inoue, and Akihide Konishi
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medicine.medical_specialty ,Glucose tolerance test ,medicine.diagnostic_test ,business.industry ,Cholesterol ,medicine.medical_treatment ,Percutaneous coronary intervention ,Odds ratio ,medicine.disease ,Surgery ,Coronary artery disease ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Conventional PCI ,medicine ,Cardiology ,business ,Prospective cohort study ,Cardiology and Cardiovascular Medicine ,Dyslipidemia - Abstract
Objectives This study sought to investigate the effect of daily glucose fluctuation on coronary plaque properties in patients with coronary artery disease (CAD) pre-treated with lipid-lowering therapy. Background There is growing evidence that glucose fluctuation, as a residual risk apart from dyslipidemia, is an important factor contributing to the development of CAD. Methods This prospective study enrolled 70 consecutive CAD patients who were referred for percutaneous coronary intervention and whose low-density lipoprotein cholesterol level was Results In total, 165 lesions were evaluated in 70 patients (40 diabetic and 30 nondiabetic patients). %NC was well correlated with MAGE (r = 0.490, p Conclusions Daily glucose fluctuation may have an effect on coronary plaque vulnerability in patients with CAD pre-treated with lipid-lowering therapy. Further investigations should address the rationale for the early detection and control of glucose fluctuation in the era of universal statin use for CAD patients.
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- 2015
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17. Impact of CD14
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Hiroyuki, Yamamoto, Naofumi, Yoshida, Toshiro, Shinke, Hiromasa, Otake, Masaru, Kuroda, Kazuhiko, Sakaguchi, Yushi, Hirota, Takayoshi, Toba, Hachidai, Takahashi, Daisuke, Terashita, Kenzo, Uzu, Natsuko, Tahara, Yuto, Shinkura, Kouji, Kuroda, Yoshinori, Nagasawa, Yuichiro, Nagano, Yoshiro, Tsukiyama, Ken-Ichi, Yanaka, Takuo, Emoto, Naoto, Sasaki, Tomoya, Yamashita, Wataru, Ogawa, and Ken-Ichi, Hirata
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Blood Glucose ,Male ,Lipopolysaccharide Receptors ,Coronary Artery Disease ,Coronary Angiography ,GPI-Linked Proteins ,Monocytes ,Predictive Value of Tests ,Humans ,Prospective Studies ,Registries ,Aged ,Aged, 80 and over ,Rupture, Spontaneous ,Receptors, IgG ,Middle Aged ,Flow Cytometry ,Coronary Vessels ,Fibrosis ,Lipids ,Plaque, Atherosclerotic ,Diabetes Mellitus, Type 2 ,Disease Progression ,Female ,Biomarkers ,Tomography, Optical Coherence - Abstract
This study examined the impact of CD14This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT. Patients were divided into 3 tertiles according to the CD14CD14CD14
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- 2017
18. Impact of CD14
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Naofumi, Yoshida, Hiroyuki, Yamamoto, Toshiro, Shinke, Hiromasa, Otake, Masaru, Kuroda, Daisuke, Terashita, Hachidai, Takahashi, Kazuhiko, Sakaguchi, Yushi, Hirota, Takuo, Emoto, Hilman Zulkifli, Amin, Taiji, Mizoguchi, Tomohiro, Hayashi, Naoto, Sasaki, Tomoya, Yamashita, Wataru, Ogawa, and Ken-Ichi, Hirata
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Aged, 80 and over ,Male ,Thin-cap fibroatheroma ,Receptors, IgG ,Lipopolysaccharide Receptors ,Coronary Artery Disease ,Middle Aged ,Coronary Angiography ,Coronary Vessels ,Monocytes ,Plaque, Atherosclerotic ,Coronary plaque vulnerability ,Cross-Sectional Studies ,Risk Factors ,Diabetes Mellitus ,CD14++CD16+ monocytes ,Humans ,Female ,Glucose fluctuations ,Ultrasonography, Interventional ,Aged ,Original Investigation - Abstract
Background Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14++CD16+ monocytes on plaque vulnerability, as assessed by virtual histology intravascular ultrasound (VH-IVUS), as well as their relationship to fluctuating glucose levels in patients with asymptomatic coronary artery disease (CAD). Methods Fifty-one patients with asymptomatic CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS evaluation for angiographically mild to moderate lesions, were enrolled in the study. Standard VH-IVUS parameters, including the percentage volume of the necrotic core (%NC) within the plaque and the presence of a virtual histology thin-cap fibroatheroma (VH-TCFA), were then evaluated. Additionally, monocyte subsets were assessed by flow cytometry, and daily glucose fluctuations were analyzed by measuring the mean amplitude of glycemic excursion (MAGE). Results Among 82 plaques from 22 diabetes mellitus (DM) patients and 29 non-DM patients, 15 VH-TCFAs were identified. CD14++CD16+ monocyte counts significantly correlated with both %NC and the presence of VH-TCFA (%NC: r = 0.339, p = 0.002; VH-TCFA: p = 0.003). Multivariate logistic regression analysis revealed that CD14++CD16+ monocyte counts were independently associated with VH-TCFA (odds ratio = 1.029, p = 0.004). Furthermore, CD14++CD16+ monocyte counts were significantly correlated with the MAGE score in the non-DM patients (r = 0.544, p = 0.005). Conclusions CD14++CD16+ monocyte levels are associated with coronary plaque vulnerability and can serve as a biomarker for VH-TCFA in patients with CAD undergoing lipid-lowering therapy. In patients without DM, glucose fluctuations may alter the balance of monocyte subsets. Trial registration UMIN Registry number: UMIN000021228 Electronic supplementary material The online version of this article (doi:10.1186/s12933-017-0577-8) contains supplementary material, which is available to authorized users.
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- 2017
19. Optical Frequency Domain Imaging Versus Intravascular Ultrasound in Percutaneous Coronary Intervention (OPINION Trial): Results From the OPINION Imaging Study
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Hiromasa, Otake, Takashi, Kubo, Hachidai, Takahashi, Toshiro, Shinke, Takayuki, Okamura, Kiyoshi, Hibi, Gaku, Nakazawa, Yoshihiro, Morino, Junya, Shite, Tetsuya, Fusazaki, Ken, Kozuma, Tetsuya, Ioji, Hideaki, Kaneda, and Takashi, Akasaka
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Adult ,Aged, 80 and over ,Male ,Time Factors ,Drug-Eluting Stents ,Coronary Artery Disease ,Middle Aged ,Young Adult ,Percutaneous Coronary Intervention ,Treatment Outcome ,Japan ,Predictive Value of Tests ,Humans ,Female ,Prospective Studies ,Tomography, Optical Coherence ,Ultrasonography, Interventional ,Aged - Abstract
The authors sought to clarify how intravascular ultrasound (IVUS) and optical coherence tomography affect percutaneous coronary intervention (PCI) with current-generation drug-eluting stents in a pre-specified substudy of the OPINION (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON) trial, a multicenter, prospective, randomized, noninferiority trial comparing optical frequency domain imaging (OFDI)-guided PCI with IVUS-guided PCI.The impact of these 2 imaging modalities in guiding PCI remains unknown.Of 829 patients enrolled in the OPINION trial, 106 were included in the present imaging substudy. Their PCI was guided by either IVUS or OFDI, but all patients were imaged by both modalities after PCI and by OFDI at 8 months. Angiographic, OFDI, and IVUS images were analyzed by independent core laboratories, and statistical analysis was done independently by a dedicated institution.A total of 103 patients underwent either OFDI-guided (n = 54) or IVUS-guided (n = 49) PCI. Immediately after PCI, OFDI-guided PCI was associated with a smaller trend of minimum stent area (5.28 ± 1.65 mmThere were several differences in local findings between OFDI- and IVUS-guided PCI as expected given the different protocols for stent sizing in the 2 groups. The minimum lumen area at the 8-month follow-up was comparable, suggesting that OFDI- and IVUS-guided PCI are similarly feasible using the current-generation drug-eluting stents. (OPtical frequency domain imaging versus INtravascular ultrasound in percutaneous coronary interventiON; NCT01873222).
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- 2017
20. Implantable Cardioverter-Defibrillator Shocks ; A Marker of Poor Prognosis but Themselves Do Not Affect Mortality
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Tomofumi Takaya, Kunihiko Kiuchi, Takayoshi Toba, Katsunori Okajima, Kousuke Aoki, Ten Saita, Yasue Tsukishiro, Akira Shimane, Yasuyo Taniguchi, Taishi Miyata, Yoshinori Yasaka, Takatoshi Hayashi, Shougo Oishi, Misato Chimura, Mitsuhiro Yokoyama, Kiminobu Yokoi, Naoki Miyoshi, Hideo Tsubata, Jin Teranishi, Hachidai Takahashi, Seiichi Kobayashi, and Shinichirou Yamada
- Subjects
medicine.medical_specialty ,Poor prognosis ,business.industry ,medicine.medical_treatment ,Medicine ,Medical emergency ,business ,Implantable cardioverter-defibrillator ,Intensive care medicine ,Affect (psychology) ,medicine.disease - Published
- 2014
21. Impact of Diabetes Mellitus on Intravascular Ultrasound-Guided Provisional Stenting in Coronary Bifurcation Lesions J-REVERSE Sub-Study
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Masahiro, Yamawaki, Daisuke, Terashita, Hachidai, Takahashi, Toshiro, Shinke, Kenichi, Fujii, Yoshihisa, Shimada, Yoshihiro, Takeda, Shinichiro, Yamada, Yoshihisa, Kinoshita, and Yoshinobu, Murasato
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Male ,Reproducibility of Results ,Drug-Eluting Stents ,Comorbidity ,Coronary Artery Disease ,Middle Aged ,Coronary Angiography ,Coronary Vessels ,Outcome and Process Assessment, Health Care ,Postoperative Complications ,Japan ,Risk Factors ,Diabetes Mellitus ,Humans ,Female ,Everolimus ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Tomography, Optical Coherence ,Ultrasonography, Interventional ,Aged - Abstract
To investigate the impact of diabetes mellitus (DM) on provisional coronary bifurcation stenting under the complete guidance of intravascular-ultrasound (IVUS).The efficacy of such intervention has not yet been fully elucidated in the DM patients.A total of 100 DM and 139 non-DM patients in a prospective multi-center registry of IVUS-guided bifurcation stenting were compared in angiographic results at 9 months. Vessel and luminal changes during the intervention were analyzed using the IVUS. Vascular healing at the follow-up was also investigated in 23 lesions in each group using optical coherence tomography (OCT).No difference was detected regarding baseline reference vessel diameter and minimum lumen diameter in proximal main vessel (MV), distal MV, and side branch (SB). The rate of everolimus-eluting stent use (78.4% vs. 78.3%), final kissing inflation (60.1% vs. 49.0%), and conversion to 2-stent strategy (2.9% vs. 2.8%) were also similar. In the DM group, late loss was greater in proximal MV (DM 0.23 ± 0.29 vs. non-DM 0.16 ± 0.24 mm, P 0.05) and SB (0.04 ± 0.49 vs. -0.08 ± 0.35 mm, P 0.05). Smaller vessel area restricted stent expansion in the proximal MV (6.18 ± 1.67 vs. 6.72 ± 2.07 mmDespite IVUS optimization for coronary bifurcation, DM is potentially associated with smaller luminal gain, higher late-loss, and inhomogeneous vascular healing with frequent thrombus attachment in the proximal MV.
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- 2016
22. Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography
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Yushi Hirota, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Masaru Kuroda, Koji Kuroda, Ken-ichi Hirata, Daiji Kashiwagi, Kenzo Uzu, Kazuhiko Sakaguchi, Yuto Shinkura, Wataru Ogawa, Toshiro Shinke, Yoshinori Nagasawa, Hiromasa Otake, Natsuko Tahara, and Daisuke Sugiyama
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Everolimus ,Glucose fluctuation ,Continuous glucose monitoring ,Aged ,Original Investigation ,Angiology ,Glycemic ,Aged, 80 and over ,Sirolimus ,Univariate analysis ,Optical coherence tomography ,business.industry ,Stent ,Drug-Eluting Stents ,Mean amplitude of glycemic excursion ,Middle Aged ,medicine.disease ,Coronary Vessels ,Surgery ,Glucose ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Tomography, Optical Coherence ,Dyslipidemia ,Mace ,Follow-Up Studies - Abstract
Background Several studies have revealed that glucose fluctuations provoke oxidative stress that leads to endothelial cell dysfunction, progression of coronary atherosclerosis, and plaque vulnerability. However, little is known regarding their effect on neointimal growth after stenting in patients with coronary artery disease (CAD). We aimed to investigate the effects of glucose fluctuations on neointimal growth after everolimus-eluting stent (EES) implantation. Methods This study examined 50 patients who underwent a 9-month follow-up using optical coherence tomography (OCT) after EES implantation. Glucose fluctuation was expressed as the mean amplitude of glycemic excursion (MAGE), and was determined via continuous glucose monitoring before stenting. At the OCT follow-up, we evaluated the percentage of uncovered struts and three-dimensional uniformity of neointimal distribution by calculating the mean neointimal thickness (NIT) within 360 equally-spaced radial sectors for every 1-mm cross-sectional OCT analysis, and assessed the incidence of major adverse cardiovascular events (MACE). Results We evaluated 60 lesions in 50 patients. Linear mixed effect models were used to explore the influence of different variables on variability in NIT and the percentage of uncovered struts and to adjust for covariates. Univariate analysis showed that MAGE was most strongly correlated with the previously mentioned OCT measurements (coefficient β ± standard error = 0.267 ± 0.073 and 0.016 ± 0.003, t = 3.668 and 6.092, both P
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- 2016
23. Transient Ischemic Right Axis Deviation Tendency of the Frontal Plane QRS Axis in a Case of Inferior Myocardial Ischemia
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Tomofumi Takaya, Ken-ichi Hirata, Kohei Hasegawa, Fumitaka Soga, Hachidai Takahashi, Shumpei Mori, Hiromasa Otake, and Daisuke Terashita
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Bundle-Branch Block ,Myocardial Ischemia ,030204 cardiovascular system & hematology ,Chest pain ,Revascularization ,Coronary Angiography ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Heart Conduction System ,Internal medicine ,medicine.artery ,medicine ,Myocardial Revascularization ,Humans ,Angina, Unstable ,Aged ,medicine.diagnostic_test ,Bundle branch block ,business.industry ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Treatment Outcome ,Right coronary artery ,Cardiology ,medicine.symptom ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,Right axis deviation ,business ,030217 neurology & neurosurgery ,Artery - Abstract
A 73-year-old man was admitted to our hospital because of chest pain at rest. Electrocardiography (ECG) showed an ST-segment depression, a negative U-wave in the precordial leads, and a right axis deviation (RAD) tendency. Coronary angiography revealed occlusion of the right coronary artery. Collateral flow from the jeopardized left anterior descending artery to the posterior descending artery (PDA) was fair. After successful revascularization, improvement in the ECG findings was noted. Since blood supply to the left posterior fascicle is dependent on the PDA, the RAD tendency could be explained by the presence of a transient ischemic left posterior hemiblock.
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- 2016
24. TCT-590 Potent effect of prasugrel on acute phase resolution of intra-stent tissue after percutaneous intervention to acute coronary syndrome
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yoshiro tsukiyama, Yuichiro Nagano, Hachidai Takahashi, Yuto Shinkura, Hiroyuki Yamamoto, Natsuko Tahara, Yoshinori Nagasawa, Kenichi Yanaka, Daisuke Terashita, Takayoshi Toba, Junya Shite, Hiromasa Otake, Kenzo Uzu, Toshiro Shinke, Amane Kozuki, Koji Kuroda, and Ken-ichi Hirata
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medicine.medical_specialty ,Acute coronary syndrome ,Prasugrel ,Percutaneous ,business.industry ,Clopidogrel ,medicine.disease ,P2Y12 ,Internal medicine ,Phase resolution ,Cardiology ,Medicine ,cardiovascular diseases ,Intra stent ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology ,medicine.drug - Abstract
Detailed mechanisms of potent and rapid antiplatelet inhibition with new-generation P2Y12 receptor inhibitor, prasugrel, has not been demonstrated. We aimed to compare the effect of prasugrel and clopidogrel on the acute phase changes of intra-stent tissue (IST) in acute coronary syndrome (ACS)
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- 2016
25. TCT-90 Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
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Takayoshi Toba, Kazuhiko Nakayama, Yuichiro Nagano, Koji Kuroda, Kenichi Yanaka, Daisuke Terashita, Naoki Tamada, Hiromasa Otake, Noriaki Emoto, Hachidai Takahashi, Natsuko Tahara, Kenzo Uzu, Yoshinori Nagasawa, Toshiro Shinke, Ken-ichi Hirata, Yuto Shinkura, Hiroyuki Yamamoto, and yoshiro tsukiyama
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medicine.medical_specialty ,business.industry ,Internal medicine ,Angioplasty ,medicine.medical_treatment ,medicine ,Cardiology ,Chronic thromboembolic pulmonary hypertension ,Cardiology and Cardiovascular Medicine ,Balloon ,business ,Surgery ,Pulmonary endarterectomy - Published
- 2016
26. TCT-361 Combined use of intravascular ultrasound and optical coherence tomography during percutaneous coronary intervention may reduce target lesion revascularization after percutaneous coronary intervention
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Masaru Kuroda, Yuto Shinkura, Tomofumi Takaya, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Ken-ichi Hirata, Toshiro Shinke, Daiji Kashiwagi, Hachidai Takahashi, Hiroto Kinutani, Yoshinori Nagasawa, Daisuke Terashita, Takayoshi Toba, and Hiromasa Otake
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medicine.medical_specialty ,genetic structures ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Imaging guidance ,Combined use ,Percutaneous coronary intervention ,equipment and supplies ,eye diseases ,surgical procedures, operative ,Optical coherence tomography ,Internal medicine ,Intravascular ultrasound ,Conventional PCI ,medicine ,Cardiology ,sense organs ,Radiology ,cardiovascular diseases ,business ,Cardiology and Cardiovascular Medicine ,Target lesion revascularization - Abstract
The clinical utility of invasive imaging guidance for percutaneous coronary intervention (PCI) has been repeatedly reported. Little is known, however, about whether the combined use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) during PCI may offer long-term clinical
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- 2015
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27. Impact of residual platelet reactivity under clopidogrel treatment for lesions and the clinical outcome after drug-eluting stent implantation in patients with hemodialysis
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Akihide Konishi, Masaru Kuroda, Tomofumi Takaya, Hiroto Kinutani, Ken-ichi Hirata, Daisuke Terashita, Tsuyoshi Osue, Toshiro Shinke, Hachidai Takahashi, and Hiromasa Otake
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Blood Platelets ,Male ,medicine.medical_specialty ,Acute coronary syndrome ,Ticlopidine ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Angina, Stable ,Aged ,Aspirin ,business.industry ,Stent ,Drug-Eluting Stents ,Thrombosis ,Middle Aged ,medicine.disease ,Clopidogrel ,Drug-eluting stent ,Case-Control Studies ,Cardiology ,Platelet aggregation inhibitor ,Drug Therapy, Combination ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,Tomography, Optical Coherence ,medicine.drug - Abstract
Background Hemodialysis (HD) patients are at high risk for adverse clinical outcomes after drug-eluting stent (DES) implantation. However, the impact of residual platelet reactivity under dual anti-platelet therapy in this subset of patients remains unclear. Methods We enrolled 142 stable angina patients (194 lesions) treated with DES, who were taking aspirin and 75 mg clopidogrel and had undergone 8-month angiography with optical coherence tomography (OCT). OCT findings and major adverse cardiac events (MACEs) at 1 year (cardiac death, acute coronary syndrome, target lesion and vessel revascularization, and stent thrombosis) were compared between 28 HD patients and 114 non-HD patients. Responsiveness to clopidogrel was assessed by measuring P2Y12 reaction unit (PRU) at 8 months. Results PRU was significantly higher in HD patients than in non-HD patients (p = 0.006), even though proportion of cytochrome P450 2C19 genotype was equivalent. HD patients had a significantly higher rate of thrombi formation (assessed using OCT) and MACEs than non-HD patients (thrombi: p = 0.001; MACEs: p = 0.0001). The PRU value was independently associated with MACEs in both groups. The optimal cutoff values of PRU for predicting MACEs were 235 for HD patients and 259 for non-HD patients. Conclusions HD was associated with a high residual platelet reactivity, which may contribute to the higher incidence of MACEs after DES implantation in HD patients. HD may be a patient profile that merits a more potent anti-platelet regimen.
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- 2015
28. Reconstruction of an Extracardiac Aortocoronary Collateral and Simulation of Selective Angiography With Multidetector-Row Computed Tomography
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Sachiko Takamine, Shumpei Mori, Ken-ichi Hirata, Toshiro Shinke, Tomofumi Takaya, Tatsuya Nishii, Hachidai Takahashi, Tatsuro Ito, Atsushi K. Kono, Sei Fujiwara, Akira Kasamatsu, and Kazuhiro Kashio
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Male ,medicine.medical_specialty ,Catheters ,Collateral ,medicine.medical_treatment ,Collateral Circulation ,Computed tomography ,Coronary Angiography ,Angina Pectoris ,Hyperlipoproteinemia Type II ,Myocardial perfusion imaging ,Percutaneous Coronary Intervention ,Physiology (medical) ,Internal medicine ,Multidetector Computed Tomography ,medicine ,Humans ,Computer Simulation ,Systole ,medicine.diagnostic_test ,business.industry ,Models, Cardiovascular ,Percutaneous coronary intervention ,Middle Aged ,Collateral circulation ,Catheter ,Angiography ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 48-year-old man with familial hypercholesterolemia was admitted to our hospital with stable angina pectoris. Stress myocardial perfusion imaging showed myocardial ischemia in the inferior left ventricular wall. Coronary angiography revealed a chronic total occlusion of the proximal right coronary artery (RCA; Figure 1A and Movie I in the online-only Data Supplement). An intercoronary collateral was observed from the atrial branch of the left circumflex artery to the posterolateral branch of the RCA (Figure 1B and Movie II in the online-only Data Supplement). Contrast material filled the distal RCA retrogradely through this collateral. However, the contrast material was flushed out antegradely by the pulsatile blood flow from the native RCA toward the posterior descending artery in systole (Figure 1B and Movie II in the online-only Data Supplement); this suggested that the second collateral flowed into a site proximal to the RCA crux. Because the second collateral could not be detected during the initial angiography, multidetector-row computed tomography (MDCT) was performed, which successfully detected and visualized the extracardiac aortocoronary collateral connecting to the mid RCA just distal to the chronic total occlusion (Figure 2). Figure 3 shows the location of the collateral on each axial image. The diameter of the collateral was measured as 1.5 mm. Figure 4 shows aortography-like volume-rendered images of the entire collateral pathway. For the subsequently scheduled percutaneous coronary intervention, the appropriate catheter for selective collateral angiography was chosen after simulation with 3-dimensional routing software (Figure 5). The shape like the Judkins Right 5.0 catheter was considered optimal for selective collateral angiography with the femoral approach. All analyses were performed with a commercially …
- Published
- 2015
29. ASSOCIATION BETWEEN DAILY GLUCOSE FLUCTUATION AND CORONARY PLAQUE PROPERTIES IN PATIENTS RECEIVING LIPID-LOWERING THERAPY ASSESSED BY CONTINUOUS GLUCOSE MONITORING AND OPTICAL COHERENCE TOMOGRAPHY: A PROSPECTIVE OBSERVATIONAL STUDY
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Ken-ichi Hirata, Tomofumi Takaya, Hiroto Kinutani, Kazuhiko Sakaguchi, Masaru Kuroda, Daisuke Terashita, Toshiro Shinke, Yushi Hirota, Koji Kuroda, Keisuke Nagasawa, Daiji Kashiwagi, Akihide Konishi, Natsuko Tahara, Hachidai Takahashi, Tsuyoshi Osue, Hiromasa Otake, Yuto Shinkura, and Kenzo Uzu
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Continuous glucose monitoring ,Lipid-lowering therapy ,Surgery ,Optical coherence tomography ,Internal medicine ,Coronary plaque ,Cardiology ,Medicine ,Observational study ,In patient ,business ,Cardiology and Cardiovascular Medicine - Published
- 2015
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30. Effect of daily glucose fluctuation on coronary plaque vulnerability in patients pre-treated with lipid-lowering therapy: a prospective observational study
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Masaru, Kuroda, Toshiro, Shinke, Kazuhiko, Sakaguchi, Hiromasa, Otake, Tomofumi, Takaya, Yushi, Hirota, Daisuke, Sugiyama, Masayuki, Nakagawa, Hirotoshi, Hariki, Takumi, Inoue, Tsuyoshi, Osue, Yu, Taniguchi, Masamichi, Iwasaki, Ryo, Nishio, Hiroto, Kinutani, Akihide, Konishi, Noritoshi, Hiranuma, Hachidai, Takahashi, Daisuke, Terashita, and Ken-Ichi, Hirata
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Blood Glucose ,Male ,Time Factors ,Monitoring, Ambulatory ,Coronary Artery Disease ,Coronary Angiography ,Necrosis ,Percutaneous Coronary Intervention ,Japan ,Predictive Value of Tests ,Risk Factors ,Odds Ratio ,Humans ,Prospective Studies ,Registries ,Ultrasonography, Interventional ,Aged ,Dyslipidemias ,Glucose Metabolism Disorders ,Hypolipidemic Agents ,Aged, 80 and over ,Rupture, Spontaneous ,Cholesterol, LDL ,Glucose Tolerance Test ,Coronary Vessels ,Fibrosis ,Plaque, Atherosclerotic ,Early Diagnosis ,Treatment Outcome ,Female ,Biomarkers - Abstract
This study sought to investigate the effect of daily glucose fluctuation on coronary plaque properties in patients with coronary artery disease (CAD) pre-treated with lipid-lowering therapy.There is growing evidence that glucose fluctuation, as a residual risk apart from dyslipidemia, is an important factor contributing to the development of CAD.This prospective study enrolled 70 consecutive CAD patients who were referred for percutaneous coronary intervention and whose low-density lipoprotein cholesterol level was120 mg/dl under statin treatment or100 mg/dl without statins. Daily glucose fluctuation was analyzed by measuring the mean amplitude of glycemic excursion (MAGE). The plaque properties in the culprit and nonculprit lesions were assessed by virtual histology intravascular ultrasound, and the volume percentage of necrotic core within the plaque (%NC) and the presence of thin-cap fibroatheroma were evaluated.In total, 165 lesions were evaluated in 70 patients (40 diabetic and 30 nondiabetic patients). %NC was well correlated with MAGE (r = 0.490, p0.001). A linear mixed effect model showed that MAGE had the strongest effect on %NC (coefficient β = 0.080 ± 0.020 [standard error], p0.001). The generalized linear mixed effect model revealed that MAGE was the only independent predictor of the presence of thin-cap fibroatheroma (odds ratio: 1.037; 95% confidence interval: 1.010 to 1.065; p = 0.007).Daily glucose fluctuation may have an effect on coronary plaque vulnerability in patients with CAD pre-treated with lipid-lowering therapy. Further investigations should address the rationale for the early detection and control of glucose fluctuation in the era of universal statin use for CAD patients.
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- 2014
31. Favorable vessel healing after nobori biolimus A9-eluting stent implantation-6- and 12-month follow-up by optical coherence tomography
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Junya Shite, Daisuke Terashita, Hiromasa Otake, Tomofumi Takaya, Toshiro Shinke, Masaru Kuroda, Masayuki Nakagawa, Hiroto Kinutani, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Masamichi Iwasaki, Akihide Konishi, Ryo Nishio, Noritoshi Hiranuma, Hachidai Takahashi, Ken-ichi Hirata, and Tsuyoshi Osue
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Neointima ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Fibrin deposition ,Lumen (anatomy) ,Biodegradable Plastics ,Optical coherence tomography ,medicine ,Stent implantation ,Humans ,Regeneration ,cardiovascular diseases ,Aged ,Neointimal hyperplasia ,Sirolimus ,Hyperplasia ,medicine.diagnostic_test ,business.industry ,Stent ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,equipment and supplies ,medicine.disease ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Tomography, Optical Coherence ,Month follow up ,Follow-Up Studies - Abstract
Background:Nobori is a novel biolimus A9-eluting stent (BES) coated with a biodegradable polymer only on the abluminal side, which degrades over 6–9 months post-stent deployment. The course of vessel reaction after deployment at these time points remains unclear.Methods and Results:We serially evaluated 28 BES implanted in de novo coronary lesions of 23 patients using optical coherence tomography (OCT) at 6 and 12 months post-stenting. Standard OCT variables, the percentage of stent with peri-strut low-intensity area (PLIA, a region around stent struts homogenously showing lesser intensity than the surrounding tissue, suggesting fibrin deposition or impaired neointima maturation) and that with in-stent thrombi were evaluated. There was a significant, but small increase in neointimal thickness (72±23 to 82±25 µm, P=0.006) from the 6- to the 12-month follow-up, without a significant decrease in minimum lumen area (P=0.30). The incidences of uncovered and malapposed struts were low at 6 months and reduced further at 12 months (3.96±3.97% to 1.51±1.63%, P=0.001, and 0.50±1.84% to 0.06±0.24%, P=0.20, respectively). The frequency of stent with PLIA decreased during the follow-up (57% to 32%, P=0.05) and that with in-stent thrombi also numerically decreased (7% to 0%, P=0.24).Conclusions:Neointimal hyperplasia was persistently suppressed following BES implantation up to 12 months. Simultaneously, favorable vessel healing was achieved at 6 months without a delaying adverse reaction for up to 12 months. (Circ J 2014; 78: 1882–1890)
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- 2014
32. TCT-329 Impaired HDL uptake capacity which measure HDL functionality may associate with target lesion revascularization through provoking neoatherosclerosis formation after stent implantation
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Maria Kiriyama, Ken-ichi Hirata, Amane Harada, Hiroyuki Yamamoto, Irino Yasuhiro, Toshiro Shinke, Koji Kuroda, Kenichi Yanaka, Hachidai Takahashi, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Tatsuro Ishida, Daisuke Terashita, Yuichiro Nagano, Hiromasa Otake, Yoshiro Tsukiyama, Katsuhiro Murakami, Yoshinori Nagasawa, Takayoshi Toba, and Toh Ryuji
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,nutritional and metabolic diseases ,Stent ,medicine.disease ,Coronary artery disease ,Medicine ,Stent implantation ,lipids (amino acids, peptides, and proteins) ,Hdl functionality ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Target lesion revascularization - Abstract
The importance of HDL functionality on coronary artery disease has been repeatedly demonstrated in recent studies. However, the association between HDL functionality and stent failure has yet to be clarified. Recently, we established a cell-free assay system to evaluate the capacity of HDL to accept
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- 2016
33. TCT-91 Efficacy of aggressive balloon pulmonary angioplasty on chronic thromboembolic pulmonary hypertension beyond normalized mean pulmonary arterial pressure
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Kenzo Uzu, Kazuhiko Nakayama, Koji Kuroda, Yuichiro Nagano, Noriaki Emoto, Hachidai Takahashi, Takayoshi Toba, Yoshiro Tsukiyama, Kenichi Yanaka, Ken-ichi Hirata, Daisuke Terashita, Naoki Tamada, Hiromasa Otake, Yoshinori Nagasawa, Yuto Shinkura, Hiroyuki Yamamoto, Natsuko Tahara, and Toshiro Shinke
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medicine.medical_specialty ,business.industry ,Angioplasty ,medicine.medical_treatment ,Internal medicine ,Cardiology ,Medicine ,Chronic thromboembolic pulmonary hypertension ,Pulmonary arterial pressure ,Cardiology and Cardiovascular Medicine ,business ,Pulmonary wedge pressure ,Balloon - Published
- 2016
34. TCT-44 The Impact of Plaque Morphology and Malapposition Area on Late Phase Stent Malapposition: Insight From Optimal Coherence Tomography Sub-study in PRASFIT Elective
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Masato Nakamura, Hiromasa Otake, Hiroto Kinutani, Masaru Kuroda, Hachidai Takahashi, Ken-ichi Hirata, Kenzo Uzu, Toshiro Shinke, Tomofumi Takaya, Junya Shite, Daisuke Terashita, Takashi Akasaka, and Shigeru Saito
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,Stent ,equipment and supplies ,surgical procedures, operative ,Late phase ,Conventional PCI ,medicine ,Plaque morphology ,cardiovascular diseases ,Radiology ,Tomography ,Cardiology and Cardiovascular Medicine ,business - Abstract
Although the occurrence of stent-malapposition (SM) after percutaneous coronary intervention (PCI) has been reduced in accordance of progress of imaging device, late acquired stent-malapposition (LASM) is still a well-recognized problem. Previous studies suggested late phase SM can be a substrate
- Published
- 2015
35. TCT-587 Impact of Immediate Vessel Reactions to Stent Deployment on Periprocedural Troponin Leakage and Mid-term Vascular Healing: Serial Optical Coherence Tomography Study after Everolimus-eluting Stent Implantation
- Author
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Yu Taniguchi, Hiromasa Otake, Masamichi Iwasaki, Hachidai Takahashi, Daisuke Terashita, Ryo Nishio, Tomofumi Takaya, Hiroto Kinutani, Akihide Konishi, Toshiro Shinke, Ken-ichi Hirata, Masaru Kuroda, Masayuki Nakagawa, and Tsuyoshi Ohsue
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medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,Everolimus eluting stent ,Vascular healing ,Optical coherence tomography ,Stent deployment ,Internal medicine ,medicine ,Stent implantation ,cardiovascular diseases ,Thrombus ,biology ,medicine.diagnostic_test ,business.industry ,Stent ,equipment and supplies ,medicine.disease ,Troponin ,eye diseases ,surgical procedures, operative ,biology.protein ,Cardiology ,sense organs ,Radiology ,business ,Cardiology and Cardiovascular Medicine - Abstract
Optical coherence tomography (OCT) can detect various types of vessel reaction immediately after stent implantation, such as stent malapposition, thrombus, prolapse, and dissection. The aim of this study was to assess how OCT findings after stenting affect on peri-procedural myocardial enzyme
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- 2013
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36. THE IMPACT OF SERUM TRANS FATTY ACIDS CONCENTRATION ON PLAQUE VULNERABILITY IN PATIENTS WITH CORONARY ARTERY DISEASE UNDER MANAGEMENT OF CONVENTIONAL RISK FACTORS: ASSESSMENT VIA OPTICAL COHERENCE TOMOGRAPHY
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Daisuke Terashita, Koji Kuroda, Kenichi Yanaka, Hachidai Takahashi, Ryuji Toh, Masaru Kuroda, Yuichiro Nagano, Takayoshi Toba, Daiji Kashiwagi, Ken-ichi Hirata, Yoshiro Tsukiyama, Hiromasa Otake, Natsuko Tahara, Toshiro Shinke, Kenzo Uzu, Yoshinori Nagasawa, Hiroyuki Yamamoto, Tomofumi Takaya, Yuto Shinkura, and Tatsuro Ishida
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Vulnerability ,medicine.disease ,Surgery ,Coronary artery disease ,Optical coherence tomography ,Internal medicine ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
37. INVESTIGATION OF HEMODYNAMIC CHANGES DURING BALLOON OCCLUSION TEST FOR PERCUTANEOUS ATRIAL SEPTAL DEFECT CLOSURE
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Daisuke Terashita, Kenichi Yanaka, Takayoshi Toba, Kenzo Uzu, Hiromasa Otake, Yoshiro Tsukiyama, Hachidai Takahashi, Hiroyuki Yamamoto, Yoshinori Nagasawa, Tomofumi Takaya, Ken-ichi Hirata, Natsuko Tahara, Masaru Kuroda, Koji Kuroda, Daiji Kashiwagi, and Toshiro Shinke
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medicine.medical_specialty ,Percutaneous ,business.industry ,Diastole ,Hemodynamics ,Atrial septal defect closure ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Balloon occlusion ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,Pulmonary wedge pressure ,business ,030217 neurology & neurosurgery ,Shunt (electrical) - Abstract
Left ventricular systolic or diastolic dysfunction may lead to elevation in pulmonary capillary wedge pressure (PCWP) during pre-balloon testing at atrial septal defect (ASD) closure, through abrupt closure of left to right shunt. However, the association between acute hemodynamic changes and
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- 2016
38. Continuous Glucose Monitoring in 2015
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Takeshi Inoue, Hiroto Kinutani, Hirotoshi Hariki, Kazuhiko Sakaguchi, Yu Taniguchi, Masamichi Iwasaki, Masaru Kuroda, Akihide Konishi, Masayuki Nakagawa, Toshiro Shinke, Daisuke Terashita, Ken-ichi Hirata, Hachidai Takahashi, Hiromasa Otake, Ryo Nishio, Tomofumi Takaya, Yushi Hirota, Daisuke Sugiyama, Noritoshi Hiranuma, and Tsuyoshi Osue
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Adult ,Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Diabetes Complications ,Coronary artery disease ,Endocrinology ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,In patient ,Child ,Prospective cohort study ,business.industry ,Blood Glucose Self-Monitoring ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Surgery ,Residual risk ,Medical Laboratory Technology ,Diabetes Mellitus, Type 1 ,Diabetes Mellitus, Type 2 ,Hyperglycemia ,Cardiology ,Observational study ,business ,Dyslipidemia - Abstract
Objectives This study sought to investigate the effect of daily glucose fluctuation on coronary plaque properties in patients with coronary artery disease (CAD) pre-treated with lipid-lowering therapy. Background There is growing evidence that glucose fluctuation, as a residual risk apart from dyslipidemia, is an important factor contributing to the development of CAD. Methods This prospective study enrolled 70 consecutive CAD patients who were referred for percutaneous coronary intervention and whose low-density lipoprotein cholesterol level was Results In total, 165 lesions were evaluated in 70 patients (40 diabetic and 30 nondiabetic patients). %NC was well correlated with MAGE (r = 0.490, p Conclusions Daily glucose fluctuation may have an effect on coronary plaque vulnerability in patients with CAD pre-treated with lipid-lowering therapy. Further investigations should address the rationale for the early detection and control of glucose fluctuation in the era of universal statin use for CAD patients.
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- 2016
39. TCT-500 Silent Occlusion, But Not Restenosis Without Occlusion After Primary Percutaneous Intervention Strongly Predicts Both Deterioration Of Cardiac Function And Future Clinical Events
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Shogo Oishi, Hachidai Takahashi, Takayoshi Toba, Kiminobu Yokoi, Tomofumi Takaya, Hiroyuki Shibata, Naoki Miyoshi, Shinichiro Yamada, Akira Shimane, Yoshinori Yasaka, Takatoshi Hayashi, and Seiichi Kobayashi
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Cardiac function curve ,medicine.medical_specialty ,Percutaneous ,Clinical events ,business.industry ,medicine.medical_treatment ,Percutaneous coronary intervention ,medicine.disease ,Restenosis ,Intervention (counseling) ,Internal medicine ,Occlusion ,Cardiology ,Medicine ,cardiovascular diseases ,Radiology ,Myocardial infarction ,business ,Cardiology and Cardiovascular Medicine - Abstract
Efficacy of primary percutaneous coronary intervention (pPCI) for acute myocardial infarction has been established by abundant evidences, however, impact of restenosis after pPCI in cardiac function or long-term prognosis remains unclear. We investigated 339 STEMI patients who had undergone pPCI
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- 2012
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40. TCT-395 Serial Optical Coherence Tomography Evaluation 6-, 12- and 24-month Follow-up after Nobori Biolimus A9-eluting Stent Implantation
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Tsuyoshi Ohsue, Hiroto Kinutani, Tomofumi Takaya, Akihide Konishi, Yu Taniguchi, Hachidai Takahashi, Noritoshi Hiranuma, Hiromasa Otake, Ryo Nishio, Daisuke Terashita, Masaru Kuroda, Masayuki Nakagawa, Toshiro Shinke, Takumi Inoue, and Masamichi Iwasaki
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medicine.diagnostic_test ,business.industry ,musculoskeletal system ,equipment and supplies ,surgical procedures, operative ,Optical coherence tomography ,cardiovascular system ,medicine ,Stent implantation ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Month follow up - Published
- 2014
41. TCT-50 Peri-strut Low Intensity Area Assessed By Mid-term Follow-up Optical Coherence Tomography May Predict Target Lesion Revascularization After Stent Implantation
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Hiromasa Otake, Tomofumi Takaya, Toshiro Shinke, Daisuke Terashita, Hiroto Kinutani, Koji Kuroda, Natsuko Tahara, Hachidai Takahashi, Kenzo Uzu, Yoshinori Nagasawa, Ken-ichi Hirata, Yuto Shinkura, Daiji Kashiwagi, and Masaru Kuroda
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Mid term follow up ,medicine.medical_specialty ,Optical coherence tomography ,medicine.diagnostic_test ,business.industry ,Peri ,medicine ,Stent implantation ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Target lesion revascularization ,Intensity (physics) - Published
- 2015
42. BENEFICIAL EFFECT OF PLATELET INHIBITION AGAINST PERI-PROCEDURAL MYOCARDIAL INFARCTION DUE TO INTRA-STENT THROMBUS PENETRATION: OPTICAL COHERENCE TOMOGRAPHY SUB-ANALYSIS IN PRASFIT ELECTIVE
- Author
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Ken-ichi Hirata, Akihide Konishi, Masamichi Iwasaki, Masato Nakamura, Junya Shite, Hiroto Kinutani, Daisuke Terashita, Toshiro Shinke, Takashi Akasaka, Masaru Kuroda, Tomofumi Takaya, Shigeru Saito, Hachidai Takahashi, Tsuyoshi Osue, Hiromasa Otake, and Kenzo Uzu
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Peri ,Penetration (firestop) ,Platelet inhibition ,medicine.disease ,Optical coherence tomography ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,Intra stent ,Myocardial infarction ,Thrombus ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
43. Impact of CD14++ CD16+ monocytes on plaque vulnerability in diabetic and non-diabetic patients with asymptomatic coronary artery disease: a cross-sectional study.
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Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Amin, Hilman Zulkifli, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, and Ken-ichi Hirata
- Subjects
CD14 antigen ,MONOCYTES ,CORONARY heart disease treatment ,ATHEROSCLEROTIC plaque ,CORONARY angiography ,CORONARY disease ,DIAGNOSIS ,GLUCOSE in the body ,PATIENTS - Abstract
Background: Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14
++ CD16+ monocytes on plaque vulnerability, as assessed by virtual histology intravascular ultrasound (VH-IVUS), as well as their relationship to fluctuating glucose levels in patients with asymptomatic coronary artery disease (CAD). Methods: Fifty-one patients with asymptomatic CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS evaluation for angiographically mild to moderate lesions, were enrolled in the study. Standard VH-IVUS parameters, including the percentage volume of the necrotic core (%NC) within the plaque and the presence of a virtual histology thin-cap fibroatheroma (VH-TCFA), were then evaluated. Additionally, monocyte subsets were assessed by flow cytometry, and daily glucose fluctuations were analyzed by measuring the mean amplitude of glycemic excursion (MAGE). Results: Among 82 plaques from 22 diabetes mellitus (DM) patients and 29 non-DM patients, 15 VH-TCFAs were identified. CD14++ CD16+ monocyte counts significantly correlated with both %NC and the presence of VH-TCFA (%NC: r = 0.339, p = 0.002; VH-TCFA: p = 0.003). Multivariate logistic regression analysis revealed that CD14++ CD16+ monocyte counts were independently associated with VH-TCFA (odds ratio = 1.029, p = 0.004). Furthermore, CD14++ CD16+ monocyte counts were significantly correlated with the MAGE score in the non-DM patients (r = 0.544, p = 0.005). Conclusions: CD14++ CD16+ monocyte levels are associated with coronary plaque vulnerability and can serve as a biomarker for VH-TCFA in patients with CAD undergoing lipid-lowering therapy. In patients without DM, glucose fluctuations may alter the balance of monocyte subsets. Trial registration UMIN Registry number: UMIN000021228 [ABSTRACT FROM AUTHOR]- Published
- 2017
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44. Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography.
- Author
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Masaru Kuroda, Toshiro Shinke, Hiromasa Otake, Daisuke Sugiyama, Tomofumi Takaya, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Daiji Kashiwagi, Koji Kuroda, Yuto Shinkura, Yoshinori Nagasawa, Kazuhiko Sakaguchi, Yushi Hirota, Wataru Ogawa, and Ken-ichi Hirata
- Subjects
PHYSIOLOGICAL effects of glucose ,EVEROLIMUS ,OPTICAL coherence tomography ,ENDOTHELIAL cells ,ATHEROSCLEROSIS ,CORONARY disease - Abstract
Background: Several studies have revealed that glucose fluctuations provoke oxidative stress that leads to endothelial cell dysfunction, progression of coronary atherosclerosis, and plaque vulnerability. However, little is known regarding their effect on neointimal growth after stenting in patients with coronary artery disease (CAD). We aimed to investigate the effects of glucose fluctuations on neointimal growth after everolimus-eluting stent (EES) implantation. Methods: This study examined 50 patients who underwent a 9-month follow-up using optical coherence tomography (OCT) after EES implantation. Glucose fluctuation was expressed as the mean amplitude of glycemic excursion (MAGE), and was determined via continuous glucose monitoring before stenting. At the OCT follow-up, we evaluated the percentage of uncovered struts and three-dimensional uniformity of neointimal distribution by calculating the mean neointimal thickness (NIT) within 360 equally-spaced radial sectors for every 1-mm cross-sectional OCT analysis, and assessed the incidence of major adverse cardiovascular events (MACE). Results: We evaluated 60 lesions in 50 patients. Linear mixed effect models were used to explore the influence of different variables on variability in NIT and the percentage of uncovered struts and to adjust for covariates. Univariate analysis showed that MAGE was most strongly correlated with the previously mentioned OCT measurements (coefficient β ± standard error = 0.267 ± 0.073 and 0.016 ± 0.003, t = 3.668 and 6.092, both P < 0.001, respectively). In multivariate analysis, MAGE had the strongest effect on variability in NIT (coefficient β ± standard error = 0.239 ± 0.093, P = 0.014) and the percentage of uncovered struts (coefficient β ± standard error = 0.019 ± 0.004, P < 0.001). Five lesions in four patients required target lesion revascularization (10.0 %) at a mean duration of 9 months after EES implantation. Compared to non-MACE cases, cases of MACE exhibited a significantly higher MAGE (99 vs. 68; P = 0.004), maximum NIT (580 vs. 330 μm; P = 0.002), and variability in NIT (100 vs. 65; P = 0.007), although there was no significant difference in these groups' HbA1c levels. Conclusions: Glucose fluctuation may affect vessel healing after EES implantation in patients with CAD who are receiving lipid-lowering therapy. Therefore, glucose fluctuations may be an important target for secondary prevention after coronary stenting, which is independent of dyslipidemia control. [ABSTRACT FROM AUTHOR]
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- 2016
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45. TCT-573 Tissue characteristics of jailed strut following single stenting to bifurcation: Optical coherence tomography assessment among four different types of drug-eluting stents
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Tomofumi Takaya, Ken-ichi Hirata, Yu Taniguchi, Masaru Kuroda, Akihide Konishi, Masayuki Nakagawa, Hachidai Takahashi, Daisuke Terashita, Ryo Nishio, Masamichi Iwasaki, Hiroto Kinutani, Hiromasa Otake, Hirotoshi Hariki, Tsuyoshi Ohsue, and Toshiro Shinke
- Subjects
medicine.medical_specialty ,Optical coherence tomography ,medicine.diagnostic_test ,business.industry ,medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Bifurcation - Published
- 2013
46. TCT-456 The Impact of Atherogenic Neointima on Long-term Clinical Outcomes: An Observational Study from the Optical Coherence Tomography Registry
- Author
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Hiroto Kinutani, Hirotoshi Hariki, Hiromasa Otake, Ryo Nishio, Masamichi Iwasaki, Masaru Kuroda, Masayuki Nakagawa, Akihide Konishi, Ken-ichi Hirata, Toshiro Shinke, Tomofumi Takaya, Tsuyoshi Ohsue, Hachidai Takahashi, Daisuke Terashita, and Yu Taniguchi
- Subjects
Neointima ,medicine.medical_specialty ,genetic structures ,medicine.diagnostic_test ,Clinical events ,business.industry ,equipment and supplies ,eye diseases ,surgical procedures, operative ,Optical coherence tomography ,medicine ,Stent implantation ,Observational study ,sense organs ,cardiovascular diseases ,Radiology ,Risk factor ,Cardiology and Cardiovascular Medicine ,business ,Pathological - Abstract
Pathological studies have revealed atherosclerotic neointima (AN) after stent implantation. However, the risk factor of neoatherosclerosis and its impact on future clinical events remain unclear. From the Kobe university OCT database, 137 consecutive patients (253 stents) who underwent OCT
- Published
- 2013
47. Association between daily glucose fluctuation and coronary plaque properties in patients receiving adequate lipid-lowering therapy assessed by continuous glucose monitoring and optical coherence tomography.
- Author
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Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Tsuyoshi Osue, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, and Ken-ichi Hirata
- Subjects
GLUCOSE ,GLYCEMIC index ,OPTICAL coherence tomography ,ATHEROSCLEROTIC plaque ,CORONARY disease - Abstract
Background: Glucose fluctuation has been recognized as a residual risk apart from dyslipidemia for the development of coronary artery disease (CAD). This study aimed to investigate the association between glucose fluctuation and coronary plaque morphology in CAD patients. Methods: This prospective study enrolled 72 consecutive CAD patients receiving adequate lipid-lowering therapy. They were divided into 3 tertiles according to the mean amplitude of glycemic excursions (MAGE), which represents glucose fluctuation, measured by continuous glucose monitoring (tertile 1; <49.1, tertile 2; 49.1 ~ 85.3, tertile 3; >85.3). Morphological feature of plaques were evaluated by optical coherence tomography. Lipid index (LI) (mean lipid arc x length), fibrous cap thickness (FCT), and the prevalence of thin-cap fibroatheroma (TCFA) were assessed in both culprit and non-culprit lesions. Results: In total, 166 lesions were evaluated. LI was stepwisely increased according to the tertile of MAGE (1958 ± 974 [tertile 1] vs. 2653 ± 1400 [tertile 2] vs. 4362 ±1858 [tertile 3], p <0.001), whereas FCT was the thinnest in the tertile 3 (157.3 ± 73.0 μm vs. 104.0 ± 64.1 μm vs. 83.1 ± 34.7 μm, p <0.001, respectively). The tertile 3 had the highest prevalence of TCFA. Multiple linear regression analysis showed that MAGE had the strongest effect on LI and FCT (standardized coefficient (3 = 0.527 and -0.392, respectively, both P <0.001). Multiple logistic analysis identified MAGE as the only independent predictor of the presence of TCFA (odds ratio 1.034; P <0.001). Conclusions: Glucose fluctuation and hypoglycemia may impact the formation of lipid-rich plaques and thinning of fibrous cap in CAD patients with lipid-lowering therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
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48. Association between daily glucose fluctuation and coronary plaque properties in patients receiving adequate lipid-lowering therapy assessed by continuous glucose monitoring and optical coherence tomography
- Author
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Yushi Hirota, Hiromasa Otake, Ken-ichi Hirata, Hiroto Kinutani, Kenzo Uzu, Daisuke Terashita, Akihide Konishi, Toshiro Shinke, Tomofumi Takaya, Hachidai Takahashi, Kazuhiko Sakaguchi, Masaru Kuroda, and Tsuyoshi Osue
- Subjects
Thin-cap fibroatheroma ,Blood Glucose ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Monitoring, Ambulatory ,Coronary Artery Disease ,Hypoglycemia ,Cohort Studies ,Coronary artery disease ,Percutaneous Coronary Intervention ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Glucose fluctuation ,Prospective Studies ,Prospective cohort study ,Continuous glucose monitoring ,Original Investigation ,Aged ,Dyslipidemias ,Hypolipidemic Agents ,Aged, 80 and over ,Optical coherence tomography ,business.industry ,Fibrous cap ,Percutaneous coronary intervention ,Mean amplitude of glycemic excursion ,Odds ratio ,Middle Aged ,medicine.disease ,Plaque, Atherosclerotic ,Logistic Models ,Endocrinology ,medicine.anatomical_structure ,Hyperglycemia ,Multivariate Analysis ,Linear Models ,Cardiology ,Female ,business ,Cardiology and Cardiovascular Medicine ,Tomography, Optical Coherence ,Dyslipidemia - Abstract
Background Glucose fluctuation has been recognized as a residual risk apart from dyslipidemia for the development of coronary artery disease (CAD). This study aimed to investigate the association between glucose fluctuation and coronary plaque morphology in CAD patients. Methods This prospective study enrolled 72 consecutive CAD patients receiving adequate lipid-lowering therapy. They were divided into 3 tertiles according to the mean amplitude of glycemic excursions (MAGE), which represents glucose fluctuation, measured by continuous glucose monitoring (tertile 1; 85.3). Morphological feature of plaques were evaluated by optical coherence tomography. Lipid index (LI) (mean lipid arc × length), fibrous cap thickness (FCT), and the prevalence of thin-cap fibroatheroma (TCFA) were assessed in both culprit and non-culprit lesions. Results In total, 166 lesions were evaluated. LI was stepwisely increased according to the tertile of MAGE (1958 ± 974 [tertile 1] vs. 2653 ± 1400 [tertile 2] vs. 4362 ± 1858 [tertile 3], p
- Full Text
- View/download PDF
49. IMPACT OF DAILY GLUCOSE FLUCTUATION ON CORONARY PLAQUE VULNERABILITY IN PATIENTS PRETREATED WITH LIPID LOWERING THERAPY
- Author
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Hachidai Takahashi, Yu Taniguchi, Kazuhiko Sakaguchi, Tomofumi Takaya, Masamichi Iwasaki, Hiromasa Otake, Ryo Nishio, Akihide Konishi, Tsuyoshi Osue, Toshiro Shinke, Masaru Kuroda, Masayuki Nakagawa, Hiroto Kinutani, Hirotoshi Hariki, Yushi Hirota, Ken-ichi Hirata, and Daisuke Terashita
- Subjects
medicine.medical_specialty ,Endocrinology ,business.industry ,Coronary plaque ,Internal medicine ,Cardiology ,medicine ,Vulnerability ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Lipid-lowering therapy - Full Text
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50. TCT-308 Intravascular Ultrasound Guided Everolimus Eluting Stent Implantation Resolves The Disadvantage Of Thin-Strut Cobalt Chromium Platform In Diabetes; Comparison Of Three Different Type Platform Stents
- Author
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Yoshinori Yasaka, Takatoshi Hayashi, Naoki Miyoshi, Kiminobu Yokoi, Tomofumi Takaya, Shinichiro Yamada, Akira Shimane, Takayoshi Toba, Seiichi Kobayashi, Shogo Oishi, and Hachidai Takahashi
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Everolimus eluting stent ,chemistry.chemical_element ,medicine.disease ,chemistry ,Diabetes mellitus ,Intravascular ultrasound ,medicine ,Radiology ,business ,Cardiology and Cardiovascular Medicine ,Cobalt - Full Text
- View/download PDF
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