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186 results on '"Hachisuka, Akiko"'

14. Estimation of dietary intake of 90Sr in Japan after the Fukushima Daiichi Nuclear Power Plant accident: market basket study, 2013–2018.

Author

Nabeshi, Hiromi, Hachisuka, Akiko, Matsuda, Rieko, Teshima, Reiko, Akiyama, Hiroshi, and Tsutsumi, Tomoaki

Subjects
*FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011, *NUCLEAR power plant accidents, *FOOD consumption, *FOOD contamination, *NUCLEAR power plants, *STRONTIUM isotopes
Abstract

Radionuclide contamination in foods has been a public concern in Japan after the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident. To estimate time and regional trends of daily intake and annual committed effective dose of strontium-90 (90Sr) after the accident, we analysed Market basket samples using a low background 2π gas-flow counter. Samples were collected from six regions, once a year from 2013 to 2018. There appeared to be little variation in estimated daily intake and annual committed effective dose of 90Sr across the time periods and regions. The estimated maximum annual committed effective dose of 90Sr was 0.00076 mSv/year, a value sufficiently lower than the intervention exemption level, 1 mSv/year, in foods in Japan. There was no noticeable difference between the range of estimated daily intake of 90Sr in this study compared with daily intake measured before the FDNPP accident. These results suggested that no obvious increase in dietary intake of 90Sr was observed after the FDNPP accident, and that the effects on commercial foods from 90Sr due to the FDNPP accident were negligible. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Rationale for Translational Research on Targeted Alpha Therapy in Japan —Renaissance of Radiopharmaceuticals Utilizing Astatine-211 and Actinium-225—

Author

Yano, Tsuneo, primary, Hasegawa, Koki, additional, Sato, Tatsuhiko, additional, Tatsumi, Mitsuaki, additional, Watabe, Tadashi, additional, Kadonaga, Yuichiro, additional, Kabayama, Kazuya, additional, Fukase, Koichi, additional, Hachisuka, Akiko, additional, Hirabayashi, Yoko, additional, Fujii, Hirofumi, additional, and Yonekura, Yoshiharu, additional

Published
2020
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28. Molecular and Clinical Elucidation of the Mechanism of Action of Steroids in Idiopathic Carpal Tunnel Syndrome.

Author

Yoshiaki Yamanaka, Takafumi Tajima, Yoshitaka Tsujimura, Kenji Kosugi, Yosuke Mano, Yukichi Zenke, Akiko Hachisuka, Takatoshi Aoki, Akinori Sakai, Yamanaka, Yoshiaki, Tajima, Takafumi, Tsujimura, Yoshitaka, Kosugi, Kenji, Mano, Yosuke, Zenke, Yukichi, Hachisuka, Akiko, Aoki, Takatoshi, and Sakai, Akinori

Subjects
CARPAL tunnel syndrome, MAGNETIC resonance imaging, MEDIAN nerve, FLEXOR tendons, INJECTIONS, STEROIDS
Abstract

Background: Carpal tunnel steroid injection is a nonoperative intervention for the treatment for idiopathic carpal tunnel syndrome (CTS). The antifibrotic, anti-inflammatory, and antiedematous properties of steroids account for their therapeutic effects in the context of CTS; however, their relative contribution has not been clarified.Methods: Fibroblasts from subsynovial connective tissues (SSCT) were intraoperatively collected from patients with idiopathic CTS and were incubated with or without the steroid triamcinolone acetonide (TA) for 1, 3, and 7 days; the expression of fibrosis-related genes and inflammatory cytokines was evaluated using quantitative reverse transcription-polymerase chain reaction. A clinical prospective study was conducted with patients who received carpal tunnel TA injections. We performed clinical and electrophysiological evaluations before and 1, 3, and 5 months after TA injection; and we compared the median nerve, flexor tendon, and SSCT areas and the median nerve flattening ratio before and 1 month after TA injection using 3-T magnetic resonance imaging (MRI).Results: TA induced downregulation of the fibrosis-related genes Col1A1 (collagen type I alpha 1 chain), Col1A2, and Col3A1 but not the inflammation-related genes. The nerve flattening ratio did not change after TA injection according to the MRI-based observation of the median nerve, flexor tendon, and SSCT areas.Conclusions: The therapeutic effects of injected TA are apparently mediated by its antifibrotic rather than its anti-inflammatory and antiedematous properties. TA probably alters the properties but not the morphology of SSCT.Level Of Evidence: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry

Author

Itoh, Satsuki, Hachisuka, Akiko, Kawasaki, Nana, Teshima, Reiko, Hayakawa, Takao, Hashii, Noritaka, Kawanishi, Toru, and Yamaguchi, Teruhide

Subjects
Glycosylation -- Analysis, Liquid chromatography -- Usage, Proteins -- Analysis, Adenosine triphosphatase -- Analysis, Biological sciences, Chemistry
Abstract

Combination of liquid chromatography and multiple-stage mass spectrometry were employed to perform a site-specific glycosylation analysis of rat brain IgLON proteins. The linkage observed between BA-2 and IgLON family protein revealed that the proteins might be the ligand proteins for the [Na.sup.+]/[K.sup.+] ATPase [beta]1 subunit and the method used might be applied to site-specific glycosylation analysis of various membrane glycoproteins.

Published
2008

41. Guidance for Post-polio Syndrome (PPS)

Author

Aoyagi, Yoichiro, primary, Sawada, Koshiro, additional, Toda, Fumi, additional, Matsushima, Yasuyuki, additional, Kinoshita, Atsushi, additional, Wada, Emiko, additional, Toki, Megumi, additional, Kawade, Nobuyuki, additional, Kobayashi, Hirotaka, additional, Hachisuka, Akiko, additional, Saeki, Satoru, additional, Kondo, Izumi, additional, and Saitoh, Eiichi, additional

Published
2017
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42. Method for Delivering Radiolabeled Single-Chain Fv Antibody to the Brain

Author

Takagi Kayoko, Okunuki Haruyo, Teshima Reiko, Sawada Jun-ichi, Hachisuka Akiko, and Nakajima Osamu

Subjects
Oligonucleotide, Health, Toxicology and Mutagenesis, chemical and pharmacologic phenomena, respiratory system, Biology, Toxicology, medicine.disease_cause, Blood–brain barrier, digestive system, Molecular biology, law.invention, Transduction (genetics), Transactivation, medicine.anatomical_structure, law, Drug delivery, medicine, biology.protein, Recombinant DNA, Antibody, Escherichia coli
Abstract

Radiolabeled antibody has attractive features as a therapeutic agent or diagnostic reagent. However, it is difficult for radiolabeled antibody to enter the central nervous system (CNS). The purpose of this study was to develop a method of delivering radiolabeled single-chain Fv (scFv) antibody into the CNS with the transactivator of transcription (TAT), one of the protein transduction domains. Oligonucleotide encoding TAT was linked to the 5′-terminal of the scFv gene. The construct was subcloned into the pET-23b vector, and the recombinant protein was expressed as an inclusion body in Escherichia coli. After solubilization and purification, the recombinant protein was oxidatively labeled with 125I, and the radiolabeled recombinant protein was injected intraperitoneally into mice. Six hours later the brains were collected and homogenized, and the protein fractions were prepared by acetone precipitation. The radioactivity in the cerebrum was about 1.6-fold higher in mice administered TAT-scFv than in those administered scFv alone. The radiolabeled TAT-scFv antibody was delivered into the cerebrum more efficiently than radiolabeled scFv antibody without TAT, suggesting that TAT peptide could be a candidate tool for delivering radiolabeled scFv antibody into the CNS.

Published
2004

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