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2. CFTR p.Arg117His associated with CBAVD and other CFTR-related disorders

Author

Thauvin-Robinet, Christel, Munck, Anne, Huet, Frédéric, de Becdelièvre, Alix, Jimenez, Clément, Lalau, Guy, Gautier, Elodie, Rollet, Jacques, Flori, Jean, Nové-Josserand, Raphaëlle, Soufir, Jean-Claude, Haloun, Alain, Hubert, Dominique, Houssin, Elise, Bellis, Gil, Rault, Gilles, David, Albert, Janny, Laurent, Chiron, Raphaël, Rives, Nathalie, Hairion, Dominique, Collignon, Patrick, Valeri, Antoine, Karsenty, Gilles, Rossi, Annick, Audrézet, Marie-Pierre, Férec, Claude, Leclerc, Julie, Georges, Marie des, Claustres, Mireille, Bienvenu, Thierry, Gérard, Bénédicte, Boisseau, Pierre, Cabet-Bey, Faïza, Cheillan, David, Feldmann, Delphine, Clavel, Christine, Bieth, Eric, Iron, Albert, Simon-Bouy, Brigitte, Izard, Vincent, Steffann, Julie, Viville, Stéphane, Costa, Catherine, Drouineaud, Véronique, Fauque, Patricia, Binquet, Christine, Bonithon-Kopp, Claire, Morris, Mike A, Faivre, Laurence, Goossens, Michel, Roussey, Michel, Girodon, Emmanuelle, Bazin, A, Blayau, M, Bonnefont, JP, Bouligand, J, Chéry, M, Chevalier-Porst, F, Costa, JM, Coude, M, Creveaux, I, Dalstein, V, Gerson, F, Gobin-Limballe, S, Gouget, AM, Kitzis, A, Lagier-Tourenne, C, Magdelaine, C, Malinge, MC, Malzac, P, Mittre, H, Petit, V, Philippe, C, Ray, P, Raynaud, M, Ronsin, C, Schmitt, S, Albert, M, Bassinet, L, Bellon, G, Bonnefoy, S, Bourouillou, G, Bremont, F, Brechard, MP, Chardot, C, Chevalier, MC, Chiesa, J, Ciolkovitch, A, Clement, A, Corvol, H, Counil, F, Costa, P, David, V, Delacourt, C, Delafontaine, D, Delepoulle, F, Delrue, MA, Deneuville, E, Derelle, J, Desrues, B, Dominique, S, Fanton, AL, Foucaud, P, Freour, T, Froment, S, Gaillard, D, Gérardin, M, Giacomini, P, Gambert, C, Gautier, E, Ginies, JL, Ginglinger, E, Gottrand, F, Guichet, A, Guillot, M, Heraud, MC, Houriez-Bertolo, E, Jeandidier, E, Journel, H, Labarière, Lahsinat, K, Langlais, S, Languepin, J, Laurans, M, Lauton, D, Layet, V, Le Bourgeois, M, Le Lannou, D, Lejeune, H, Lenoir, G, Leroy, S, Lestrade, F, Llerena, C, Marc, B, Marchand, S, Marguet, C, Marteletti, O, Massat, G, Masurel-Paulet, A, Mely, L, Menetrey, C, Moisan-Petit, V, Montcouquiol, S, Moreau, L, Odent, S, Pagenault, M, Parent, P, Pautard, JC, Perez-Martin, S, Peter, MO, Pierre, D, Pin, I, Plessis, G, Ramel, S, Rembert-Sagot, F, Roux, C, Royere, D, Sardet, A, Sarles, J, Sermet-Gaudelus, I, Siffroi, JP, Saulnier, JP, Sehabiague, J, Sinet, PM, Tassin, E, Terro, F, Turck, D, Vodoff, MV, Wagner, L, and Weiss, L

Published
2013
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5. Real-Life Safety and Effectiveness of Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis

Author

Burgel, Pierre-Régis, primary, Munck, Anne, additional, Durieu, Isabelle, additional, Chiron, Raphaël, additional, Mely, Laurent, additional, Prevotat, Anne, additional, Murris-Espin, Marlene, additional, Porzio, Michele, additional, Abely, Michel, additional, Reix, Philippe, additional, Marguet, Christophe, additional, Macey, Julie, additional, Sermet-Gaudelus, Isabelle, additional, Corvol, Harriet, additional, Bui, Stéphanie, additional, Lemonnier, Lydie, additional, Dehillotte, Clémence, additional, Da Silva, Jennifer, additional, Paillasseur, Jean-Louis, additional, Hubert, Dominique, additional, Mounard, Julie, additional, Poulet, Claire, additional, Rames, Cinthia, additional, Person, Christine, additional, Troussier, Françoise, additional, Urban, Thierry, additional, Dalphin, Marie-Laure, additional, Dalphin, Jean-Claude, additional, Pernet, Didier, additional, Richaud-Thiriez, Bénédicte, additional, Fayon, Mickael, additional, Macey-Caro, Julie, additional, Campbell, Karine, additional, Laurans, Muriel, additional, Borderon, Corinne, additional, Heraud, Marie-Christine, additional, Labbé, André, additional, Montcouquiol, Sylvie, additional, Bassinet, Laurence, additional, Remus, Natascha, additional, Fanton, Annlyse, additional, Houzel-Charavel, Anne, additional, Huet, Frédéric, additional, Perez-Martin, Stéphanie, additional, Boldron-Ghaddar, Amale, additional, Scalbert, Manuela, additional, Camara, Boubou, additional, Llerena, Catherine, additional, Pin, Isabelle, additional, Quétant, Sébastien, additional, Cottereau, Aurélie, additional, Deschildre, Antoine, additional, Gicquello, Alice, additional, Perez, Thierry, additional, Stervinou-Wemeau, Lidwine, additional, Thumerelle, Caroline, additional, Wallaert, Benoit, additional, Wizla, Nathalie, additional, Languepin, Jane, additional, Ménétrey, Céline, additional, Dupuy-Grasset, Magalie, additional, Bazus, Lucie, additional, Buchs, Clelia, additional, Jubin, Virginie, additional, Werck-Gallois, Marie-Christine, additional, Mainguy, Catherine, additional, Perrin, Thomas, additional, Toutain-Rigolet, Agnès, additional, Durupt, Stéphane, additional, Reynaud, Quitterie, additional, Nove-Josserand, Raphaele, additional, Baravalle-Einaudi, Melisande, additional, Coltey, Bérangère, additional, Dufeu, Nadine, additional, Dubus, Jean-Christophe, additional, Stremler, Nathalie, additional, Caimmi, Davide, additional, Billon, Yves, additional, Derelle, Jocelyne, additional, Kieffer, Sébastien, additional, Pichon, Anne-Sophie, additional, Schweitzer, Cyril, additional, Tatopoulos, Aurélie, additional, Abbes, Sarah, additional, Bihouée, Tiphaine, additional, Danner-Boucher, Isabelle, additional, David, Valérie, additional, Haloun, Alain, additional, Tissot, Adrien, additional, Leroy, Sylvie, additional, Bailly-Piccini, Carole, additional, Clément, Annick, additional, Tamalet, Aline, additional, Burgel, Pierre-Régis, additional, Honoré, Isabelle, additional, Kanaan, Reem, additional, Martin, Clémence, additional, Bailly, Cécile, additional, Chédevergne, Frédérique, additional, De Blic, Jacques, additional, Fauroux, Brigitte, additional, Le Bourgeois, Murielle, additional, Delaisi, Bertrand, additional, Gérardin, Michèle, additional, Abély, Michel, additional, Ravoninjatovo, Bruno, additional, Belleguic, Chantal, additional, Desrues, Benoit, additional, Brinchault, Graziella, additional, Dagorne, Michel, additional, Deneuville, Eric, additional, Lefeuvre, Sylvaine, additional, Dirou, Anne, additional, Le Bihan, Jean, additional, Ramel, Sophie, additional, Dominique, Stéphane, additional, Payet, Annabelle, additional, Kessler, Romain, additional, Rosner, Vincent, additional, Weiss, Laurence, additional, de Miranda, Sandra, additional, Grenet, Dominique, additional, Hamid, Abdoul, additional, Picard, Clément, additional, Brémont, François, additional, Didier, Alain, additional, Labouret, Géraldine, additional, Mittaine, Marie, additional, Murris-Espin, Marlène, additional, Têtu, Laurent, additional, Cosson, Laure, additional, Giraut, Charlotte, additional, Henriet, Anne-Cécile, additional, Mankikian, Julie, additional, Marchand, Sophie, additional, Hugé, Sandrine, additional, Storni, Véronique, additional, and Coirier-Duet, Emmanuelle, additional

Published
2020
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9. Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology

Author

Rammaert, Blandine, Puyade, Mathieu, Cornely, Oliver A., Seidel, Danila, Grossi, Paolo, Husain, Shahid, Picard, Clement, Lass-Floerl, Cornelia, Manuel, Oriol, Le Pavec, Jerome, Lortholary, Olivier, Nagel, Claudia, Westall, Glen, Morrissey, Orla, Chambers, Daniel, Eschertzhuber, Stephan, Coussement, Julien, Vos, Robin, Dupont, Lieven, Dumonceaux, Michel, Campos, Silvia Vidal, Kabbani, Dima, Cervera, Carlos, Blanchard, Elodie, Senechal, Agathe, Brugiere, Olivier, Boussaud, Veronique, Guillemain, Romain, Bervar, Jean-Francois, Claustre, Johanna, Haloun, Alain, Hirschi, Sandrine, Reynaud, Martine, Kneidinger, Nikolaus, Gottlieb, Jens, Roilides, Emmanuel, Zarrinfar, Hossein, Rosso, Lorenzo, Morlacchi, Letizia Corinna, Dell'Amore, Andrea, Loy, Monica, dos Santos, Claudy Oliveira, Monforte, Victor, Teresa Martin-Gomez, Maria, Lopez Medrano, Francisco, Fernandez-Ruiz, Mario, Sole, Amparo, Cifrian, Jose M., Neofytos, Dionysios, Mueller, Nicolas, Benden, Christian, Brill, Anne Kathrin, Kiyan, Esen, Gould, Kate, Gkrania-Klotsas, Effrossyni, David, Miruna, Weigt, Sam, Kwak, Eun Jeong, Silveira, Femanda, Hadjiliadis, Denis, Baddley, John, Danziger-Isakov, Lara, Bhorade, Sangeeta, Ison, Michael, Wolfe, Cameron, Aslam, Saima, Budem, Marie, Musetti, Ana, Rammaert, Blandine, Puyade, Mathieu, Cornely, Oliver A., Seidel, Danila, Grossi, Paolo, Husain, Shahid, Picard, Clement, Lass-Floerl, Cornelia, Manuel, Oriol, Le Pavec, Jerome, Lortholary, Olivier, Nagel, Claudia, Westall, Glen, Morrissey, Orla, Chambers, Daniel, Eschertzhuber, Stephan, Coussement, Julien, Vos, Robin, Dupont, Lieven, Dumonceaux, Michel, Campos, Silvia Vidal, Kabbani, Dima, Cervera, Carlos, Blanchard, Elodie, Senechal, Agathe, Brugiere, Olivier, Boussaud, Veronique, Guillemain, Romain, Bervar, Jean-Francois, Claustre, Johanna, Haloun, Alain, Hirschi, Sandrine, Reynaud, Martine, Kneidinger, Nikolaus, Gottlieb, Jens, Roilides, Emmanuel, Zarrinfar, Hossein, Rosso, Lorenzo, Morlacchi, Letizia Corinna, Dell'Amore, Andrea, Loy, Monica, dos Santos, Claudy Oliveira, Monforte, Victor, Teresa Martin-Gomez, Maria, Lopez Medrano, Francisco, Fernandez-Ruiz, Mario, Sole, Amparo, Cifrian, Jose M., Neofytos, Dionysios, Mueller, Nicolas, Benden, Christian, Brill, Anne Kathrin, Kiyan, Esen, Gould, Kate, Gkrania-Klotsas, Effrossyni, David, Miruna, Weigt, Sam, Kwak, Eun Jeong, Silveira, Femanda, Hadjiliadis, Denis, Baddley, John, Danziger-Isakov, Lara, Bhorade, Sangeeta, Ison, Michael, Wolfe, Cameron, Aslam, Saima, Budem, Marie, and Musetti, Ana

Abstract

Background Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. Results A total of 51 respondents from 45 lung transplant centers (17 countries, 4 continents) answered the survey (response rate 58%). S/L colonization was estimated to be detected in candidates by 48% of centers. Only 18% of the centers used a specific medium to detect S/L colonization. Scedosporium spp. colonization was a contraindication to transplantation in 10% of centers whereas L prolificans was a contraindication in 31%; 22% of centers declared having had 1-5 recipients infected with S/L in the past 5 years. Conclusions This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.

Published
2019

13. Scédosporiose disséminée après transplantation pulmonaire : une complication rare chez le patient atteint de mucoviscidose

Author

Morio, Florent, Horeau-Langlard, Delphine, Gay-Andrieu, Françoise, Talarmin, Jean-Philippe, Haloun, Alain, Treilhaud, Michelle, Toquet, C., Nourry, Laurence, Danner-Boucher, Isabelle, Pattier, Sabine, Bouchara, Jean-Philippe, Le Pape, Patrice, Miégeville, M., Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), and Université d'Angers (UA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 06/2009

Published
2009

17. Fatal Invasive Infection with Fungemia Due to Microascus cirrosus after Heart and Lung Transplantation in a Patient with Cystic Fibrosis

Author

Miossec, Charline, primary, Morio, Florent, additional, Lepoivre, Thierry, additional, Le Pape, Patrice, additional, Garcia-Hermoso, Dea, additional, Gay-Andrieu, Françoise, additional, Haloun, Alain, additional, Treilhaud, Michele, additional, Leclair, François, additional, and Miegeville, Michel, additional

Published
2011
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18. Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

Author

Humbert, Marc, primary, Sitbon, Olivier, additional, Chaouat, Ari, additional, Bertocchi, Michèle, additional, Habib, Gilbert, additional, Gressin, Virginie, additional, Yaïci, Azzedine, additional, Weitzenblum, Emmanuel, additional, Cordier, Jean-François, additional, Chabot, François, additional, Dromer, Claire, additional, Pison, Christophe, additional, Reynaud-Gaubert, Martine, additional, Haloun, Alain, additional, Laurent, Marcel, additional, Hachulla, Eric, additional, Cottin, Vincent, additional, Degano, Bruno, additional, Jaïs, Xavier, additional, Montani, David, additional, Souza, Rogério, additional, and Simonneau, Gérald, additional

Published
2010
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19. Disseminated Scedosporium / Pseudallescheria Infection after Double-Lung Transplantation in Patients with Cystic Fibrosis

Author

Morio, Florent, primary, Horeau-Langlard, Delphine, additional, Gay-Andrieu, Françoise, additional, Talarmin, Jean-Philippe, additional, Haloun, Alain, additional, Treilhaud, Michelle, additional, Despins, Philippe, additional, Jossic, Frédérique, additional, Nourry, Laurence, additional, Danner-Boucher, Isabelle, additional, Pattier, Sabine, additional, Bouchara, Jean-Philippe, additional, Le Pape, Patrice, additional, and Miegeville, Michel, additional

Published
2010
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20. Influence of Donor Characteristics on Outcome After Lung Transplantation: A Multicenter Study

Author

Thabut, Gabriel, primary, Mal, Hervé, additional, Cerrina, Jacques, additional, Dartevelle, Philippe, additional, Dromer, Claire, additional, Velly, Jean-François, additional, Stern, Marc, additional, Loirat, Philippe, additional, Bertocchi, Michelle, additional, Mornex, Jean-François, additional, Haloun, Alain, additional, Despins, Philippe, additional, Pison, Christophe, additional, Blin, Daniel, additional, Simonneau, Gerald, additional, and Reynaud-Gaubert, Martine, additional

Published
2005
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22. Pregnancy and heart-lung transplantation

Author

Baron, Olivier, primary, Hubaut, Jean Jacques, additional, Galetta, Domenico, additional, Treilhaud, Michelle, additional, Horeau, Delphine, additional, Despins, Phillipe, additional, Michaud, Jean Luc, additional, and Haloun, Alain, additional

Published
2002
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23. Fatal Invasive Infection with Fungemia Due to Microascus cirrosusafter Heart and Lung Transplantation in a Patient with Cystic Fibrosis

Author

Miossec, Charline, Morio, Florent, Lepoivre, Thierry, Le Pape, Patrice, Garcia-Hermoso, Dea, Gay-Andrieu, Françoise, Haloun, Alain, Treilhaud, Michele, Leclair, François, and Miegeville, Michel

Abstract

ABSTRACTScopulariopsisspecies are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsisspecies, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascusinfections are discussed.

Published
2011
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24. Disseminated Scedosporium/PseudallescheriaInfection after Double-Lung Transplantation in Patients with Cystic Fibrosis

Author

Morio, Florent, Horeau-Langlard, Delphine, Gay-Andrieu, Franc¸oise, Talarmin, Jean-Philippe, Haloun, Alain, Treilhaud, Michelle, Despins, Philippe, Jossic, Fre´de´rique, Nourry, Laurence, Danner-Boucher, Isabelle, Pattier, Sabine, Bouchara, Jean-Philippe, Le Pape, Patrice, and Miegeville, Michel

Abstract

ABSTRACTWe report a case of disseminated Scedosporium/Pseudallescheriainfection due to Pseudallescheria boydiisensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.

Published
2010
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25. Gallibacterium anatisBacteremia in a Human

Author

Aubin, Guillaume Ghislain, Haloun, Alain, Treilhaud, Michèle, Reynaud, Alain, and Corvec, Stéphane

Abstract

ABSTRACTWe describe the first case of bacteremia due to Gallibacterium anatis. The patient, a 26-year-old woman, developed bacteremia and diarrhea. The origin of infection was possibly due to a diet contaminated by G. anatisin this highly immunocompromised patient.

Published
2013
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27. Delayed Gastric Emptying Scintigraphy in Cystic Fibrosis Patients Before and After Lung Transplantation

Author

Bodet-Milin, Caroline, Querellou, Solène, Oudoux, Aurore, Haloun, Alain, Horeau-Llanglard, Delphine, Carlier, Thomas, Bizais, Yves, and Couturier, Olivier

Subjects
*HEART transplant recipients, *LUNG transplantation, *CYSTIC fibrosis, *LUNG diseases, *PREOPERATIVE care
Abstract

Background: The purpose of this study was to assess the rate of gastric emptying (GE) in cystic fibrosis patients scheduled for lung transplantation. Methods: Thirty patients (20 males, 10 females, 22.6 ± 6.4 years) were evaluated by GE scintigraphy before (1.58 ± 1.11 years) and early after (5.8 ± 2.6 weeks) heart–lung transplantation (n = 13) or lung transplantation (n = 17). Solid retention rates at 2 hours (RR2) and 3 hours (RR3) and half-emptying times (T50) of solids and liquids obtained before transplantation were compared with those after transplantation. Data were also compared with those obtained from a control group of 53 healthy volunteers. Results: Before surgery, 20 patients (67%) showed a delayed GE (T50 of solids: patients 160.86 ± 59.21 minutes vs controls 75.43 ± 15.13 minutes, p < 0.0001), and 4 of them also had a delayed T50 of liquids. After surgery, the T50 of solids was considered unreliable (too much stasis) in 24 patients. Thus, analyses were done on the basis of solid retention rates. Twenty-nine patients (97%) showed very delayed GE compared with controls (p < 0.0001), 20 of whom also had a delayed T50 of liquids. RR2 and RR3 were significantly higher after surgery than before (RR2 = 86 ± 17% and RR3 = 77 ± 22% vs 50 ± 24% and 27 ± 24% after and before surgery, respectively, p < 0.0001). However, there was no correlation between pre- and post-transplantation scintigraphy results. Conclusions: Delayed GE of solids was a frequent abnormality in patients with end-stage cystic fibrosis, with a dramatic delay after surgery in almost all patients. These results emphasize the need for early management of such patients by dietary manipulation or prokinetic medications. [Copyright &y& Elsevier]

Published
2006
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28. Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.

Author

Morio F, Horeau-Langlard D, Gay-Andrieu F, Talarmin JP, Haloun A, Treilhaud M, Despins P, Jossic F, Nourry L, Danner-Boucher I, Pattier S, Bouchara JP, Le Pape P, and Miegeville M

Subjects
Adult, Antifungal Agents therapeutic use, Brain diagnostic imaging, Caspofungin, Chemoprevention methods, DNA, Fungal chemistry, DNA, Fungal genetics, Echinocandins therapeutic use, Fatal Outcome, Female, Humans, Lipopeptides, Lung Diseases, Fungal drug therapy, Lung Diseases, Fungal microbiology, Lung Diseases, Fungal surgery, Magnetic Resonance Imaging, Microbial Sensitivity Tests, Microscopy, Molecular Sequence Data, Naphthalenes therapeutic use, Pseudallescheria classification, Pseudallescheria cytology, Pseudallescheria genetics, Pyrimidines therapeutic use, RNA, Fungal genetics, RNA, Ribosomal, 28S genetics, Radiography, Scedosporium classification, Scedosporium cytology, Scedosporium genetics, Sequence Analysis, DNA, Terbinafine, Triazoles therapeutic use, Voriconazole, Cystic Fibrosis therapy, Lung Diseases, Fungal diagnosis, Lung Transplantation adverse effects, Pseudallescheria isolation & purification, Scedosporium isolation & purification
Abstract

We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.

Published
2010
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29. [Lung and heart-lung transplantation in cystic fibrosis].

Author

Haloun A and Despins P

Subjects
Contraindications, France epidemiology, Humans, Survival Rate, Transplantation Conditioning, Treatment Outcome, Waiting Lists, Cystic Fibrosis surgery, Heart-Lung Transplantation mortality, Lung Transplantation mortality
Abstract

Lung transplantation is a valid treatment in cystic fibrosis patients at end stage of the disease. It is decided when the vital prognosis seems to be engaged within two years. Patients are put on the waiting list after they have been checked out according to their individual potential risks and difficulties. The waiting time on list may be prolonged and should be used to optimize nutritional status (gastrostomy) and to take into account the psychological aspect of the project. The choice between double lung transplantation and heart lung transplantation depends on teams experience. Survival rate is increasing (until 90% and 78% survival rate at 1 and 5 years). Contra-indications are represented by a dependence on invasive assisted ventilation before referral to transplant, and adhesions after surgical pleurectomy. Long term results depend on bronchiolitis obliterans which is for some teams an opportunity to discuss the possibility of retransplantation.

Published
2003

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