1. Human leukemic cells: Receptor binding and biological effects of insulin and insulin-like growth factors
- Author
-
Jurgen Zapf, Ulrich Vetter, G. Gaedicke, W. Hartmann, Wolfgang Heit, Hans Hitzler, Eberhard Heinze, Peter V. Byrne, Jurgen H.M. Schlickenrieder, and Walter M. Teller
- Subjects
Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Cell Line ,Somatomedins ,Cell surface receptor ,hemic and lymphatic diseases ,Insulin receptor substrate ,Internal medicine ,medicine ,Humans ,Insulin ,Glycogen synthase ,Leukemia ,biology ,DNA synthesis ,Growth factor ,Receptors, Somatomedin ,DNA ,Hematology ,Receptor, Insulin ,Insulin receptor ,Endocrinology ,Oncology ,Insulin receptor binding ,biology.protein ,Glycogen - Abstract
Receptor binding and biological effects of insulin and insulin-like growth factors I and II (IGF I/II) were assessed in three human malignant cell lines: a Burkitt-type ALL-cell line, a ANLL-cell line and a Hodgkin's disease-cell line. Insulin receptor binding could be demonstrated in Burkitt-type ALL cells and ANLL cells, whereas no insulin receptor binding was detectable in Hodgkin cells. IGF I and IGF II binding could be demonstrated in all leukemic cells. Insulin stimulated glycogen synthesis in the insulin receptor bearing cell lines. DNA synthesis was stimulated by insulin, IGF I and II. IGF I was more active in stimulating DNA synthesis than IGF II.
- Published
- 1986
- Full Text
- View/download PDF