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8 results on '"Hearing Loss/epidemiology"'

1. Influence of infancy care strategy on hearing in children and adolescents: A longitudinal study of children with unilateral lip and /or cleft palate

Author

Anthony de Buys Roessingh, Mélody Artaz, Oumama El Ezzi, Maryna Kapitanova, Céline Richard, and Jean-François Knebel

Subjects
Adolescent, Child, Child, Preschool, Cleft Lip/epidemiology, Cleft Palate/epidemiology, Female, Hearing Loss/epidemiology, Humans, Longitudinal Studies, Male, Middle Ear Ventilation, Myringosclerosis/epidemiology, Otitis Media with Effusion/epidemiology, Retrospective Studies, Switzerland/epidemiology, Tympanic Membrane/abnormalities, Complications, Hearing loss, Long-term outcomes, Unilateral cleft lip and palate, Pediatrics, medicine.medical_specialty, Longitudinal study, Tympanic Membrane, Cleft Lip, Population, 03 medical and health sciences, 0302 clinical medicine, medicine, otorhinolaryngologic diseases, 030212 general & internal medicine, 030223 otorhinolaryngology, education, Hearing Loss, education.field_of_study, business.industry, Otitis Media with Effusion, Incidence (epidemiology), Myringosclerosis, General Medicine, Cleft Palate, medicine.anatomical_structure, Otitis, Otorhinolaryngology, Effusion, Pediatrics, Perinatology and Child Health, Middle ear, medicine.symptom, Age of onset, business, Switzerland
Abstract

Objectives To evaluate the relation between ventilation tube insertion, otitis media with effusion duration and otologic outcomes in unilateral cleft lip and/or cleft palate children from infancy to teenage age. Design and population Retrospective longitudinal charts review of patients from the multidisciplinary cleft team of the University Hospital of Lausanne over a 30-year period. 146 charts from consecutive patients with non-syndromic unilateral cleft lip and/or cleft palate who were born between January 1986 and January 2003 were included. Results The earlier in life a cleft child experience his first otitis media with effusion (OME), the worse his long-term hearing will be. Along with the age of onset of OME, we disclosed an influence of the duration of OME without ventilation tube (VT) insertion on short and long-term hearing outcomes. Different patterns were observed between cleft palate (CP) and cleft lip palate children (CLP), with a higher incidence of otitis media with effusion for the CLP group than the CP group. Direct positive relationship between VT insertion and hearing were disclosed and evaluation of long-term complications did not reveal significant relation with VT insertion. Of note, OME in CLP children led to a higher rate (but not statistically significant) of chronic ear complications than in the CP group, that may indicate more persistent OME or different adverse effect on the middle ear mucosa between CP and CLP children. Conclusions Individualized counseling should take into account different factors such as the type of cleft, the age of onset of OME and duration of OME, keeping in mind the adverse effect of persistent middle ear fluid. In the present report, results prone an early ventilation tube insertion to prevent short and long-term injury to the middle ear homeostasis, hearing loss and related issues.

Published
2018

2. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study

Author

Pierrat, Véronique, Marchand-Martin, Laetitia, Arnaud, Catherine, Kaminski, Monique, Resche-Rigon, Matthieu, Lebeaux, Cécile, Bodeau-Livinec, Florence, Morgan, Andrei S., Goffinet, François, Marret, Stéphane, Ancel, Pierre-Yves, Rozé, Jean-Christophe, Flamant, Cyril, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre Hospitalier Universitaire de Lille (CHU de Lille), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de l'information médicale et de la biostatistique [AP-HP Hôpital Saint-Louis], AP-HP Hôpital Saint-Louis, Département Méthodes quantitatives en santé publique (METIS), École des Hautes Études en Santé Publique [EHESP] (EHESP), DHU Risques Et Grossesse, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service de pédiatrie néonatale et réanimation - neuropédiatrie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), This project has been funded with support from the following organisations: The French Institute of Public Health Research/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), The National Research Agency through the French EQUIPEX program of investments in the future (reference ANR-11-EQPX-0038), the PREMUP Foundation, Fondation de France (reference 00050329), and Fondation pour la Recherche Médicale (reference SPF20160936356)., ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), pierrat, veronique, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique ( CRESS - U1153 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité ( CRESS (U1153 / UMR_A 1125) ), Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Recherche Agronomique ( INRA ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Universitaire de Lille ( CHU de Lille ), Épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Département Méthodes quantitatives en santé publique ( METIS ), École des Hautes Études en Santé Publique [EHESP] ( EHESP ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Assistance publique - Hôpitaux de Paris (AP-HP), CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Hôpital Charles Nicolle [Rouen], Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques ( GPMCND ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institute for Research and Innovation in Biomedicine ( IRIB ), CIC - Mère Enfant Necker Cochin Paris Centre ( CIC 1419 ), CHU Cochin [AP-HP]-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), ANR-11-EQPX-0038/11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance ( 2011 ), CHU Lille, Université de Lille, Hôpital Jeanne de Flandre [Lille], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Université Toulouse III - Paul Sabatier [UT3], and Hôpital Saint-Louis

Subjects
Male, Pediatrics, Developmental Disabilities, [ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Infant, Premature, Diseases, Blindness, Population based cohort, Corrected Age, 0302 clinical medicine, 030202 anesthesiology, Outcome Assessment, Health Care, MESH: Blindness/epidemiology, Blindness/etiology, Cerebral Palsy/epidemiology, Cerebral Palsy/etiology, Child, Preschool, Developmental Disabilities/epidemiology, Developmental Disabilities/etiology, Female, Follow-Up Studies, France/epidemiology, Gestational Age, Hearing Loss/epidemiology, Hearing Loss/etiology, Humans, Infant, Extremely Premature, Infant, Premature, Diseases/epidemiology, Infant, Premature, Diseases/mortality, Infant, Premature, Diseases/physiopathology, Outcome Assessment (Health Care), Prospective Studies, Survivors, 030212 general & internal medicine, Prospective cohort study, education.field_of_study, 030219 obstetrics & reproductive medicine, Gestational age, Gross Motor Function Classification System, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, 3. Good health, Gestation, France, Cohort study, medicine.medical_specialty, Pédiatrie, Population, Cerebral palsy, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 030225 pediatrics, medicine, education, Hearing Loss, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, Cerebral Palsy, Research, medicine.disease, Confidence interval, MESH : Blindness/epidemiology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

International audience; Objectives To describe neurodevelopmental outcomes at 2 years corrected age for children born alive at 22-26, 27-31, and 32-34 weeks' gestation in 2011, and to evaluate changes since 1997.Design Population based cohort studies, EPIPAGE and EPIPAGE-2.Setting France.Participants 5567 neonates born alive in 2011 at 22-34 completed weeks' gestation, with 4199 survivors at 2 years corrected age included in follow-up. Comparison of outcomes reported for 3334 (1997) and 2418 (2011) neonates born alive in the nine regions participating in both studies.Main outcome measures Survival; cerebral palsy (2000 European consensus definition); scores below threshold on the neurodevelopmental Ages and Stages Questionnaire (ASQ; at least one of five domains below threshold) if completed between 22 and 26 months corrected age, in children without cerebral palsy, blindness, or deafness; and survival without severe or moderate neuromotor or sensory disabilities (cerebral palsy with Gross Motor Function Classification System levels 2-5, unilateral or bilateral blindness or deafness). Results are given as percentage of outcome measures with 95% confidence intervals.Results Among 5170 liveborn neonates with parental consent, survival at 2 years corrected age was 51.7% (95% confidence interval 48.6% to 54.7%) at 22-26 weeks' gestation, 93.1% (92.1% to 94.0%) at 27-31 weeks' gestation, and 98.6% (97.8% to 99.2%) at 32-34 weeks' gestation. Only one infant born at 22-23 weeks survived. Data on cerebral palsy were available for 3599 infants (81.0% of the eligible population). The overall rate of cerebral palsy at 24-26, 27-31, and 32-34 weeks' gestation was 6.9% (4.7% to 9.6%), 4.3% (3.5% to 5.2%), and 1.0% (0.5% to 1.9%), respectively. Responses to the ASQ were analysed for 2506 children (56.4% of the eligible population). The proportion of children with an ASQ result below threshold at 24-26, 27-31, and 32-34 weeks' gestation were 50.2% (44.5% to 55.8%), 40.7% (38.3% to 43.2%), and 36.2% (32.4% to 40.1%), respectively. Survival without severe or moderate neuromotor or sensory disabilities among live births increased between 1997 and 2011, from 45.5% (39.2% to 51.8%) to 62.3% (57.1% to 67.5%) at 25-26 weeks' gestation, but no change was observed at 22-24 weeks' gestation. At 32-34 weeks' gestation, there was a non-statistically significant increase in survival without severe or moderate neuromotor or sensory disabilities (P=0.61), but the proportion of survivors with cerebral palsy declined (P=0.01).Conclusions In this large cohort of preterm infants, rates of survival and survival without severe or moderate neuromotor or sensory disabilities have increased during the past two decades, but these children remain at high risk of developmental delay.

Published
2017
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3. A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

Author

Bowl, Michael R., Simon, Michelle M., Ingham, Neil J., Greenaway, Simon, Santos, Luis, Cater, Heather, Taylor, Sarah, Mason, Jeremy, Kurbatova, Natalja, Pearson, Selina, Bower, Lynette R., Clary, Dave A., Meziane, Hamid, Reilly, Patrick, Minowa, Osamu, Kelsey, Lois, Allen, Sue, Clementson-Mobbs, Sharon, Codner, Gemma, Fray, Martin, Gardiner, Wendy, Joynson, Russell, Kenyon, Janet, Loeffler, Jorik, Nell, Barbara, Parker, Andrew, Quwailid, Deen, Stewart, Michelle, Walling, Alison, Zaman, Rumana, Chen, Chao Kung, Conte, Nathalie, Matthews, Peter, Relac, Mike, Tudose, Ilinca, Warren, Jonathan, Le Marchand, Elise, El Amri, Amal, El Fertak, Leila, Ennah, Hamid, Ali-Hadji, Dalila, Ayadi, Abdel, Wattenhofer-Donze, Marie, Moulaert, David, Jacquot, Sylvie, André, Philippe, Birling, Marie Christine, Pavlovic, Guillaume, Lalanne, Valérie, Lux, Aline, Riet, Fabrice, Mittelhaeuser, Christophe, Bour, Raphael, Guimond, Alain, Bam'Hamed, Chaouki, Leblanc, Sophie, Vasseur, Laurent, Selloum, Mohammed, Sorg, Tania, Ayabe, Shinya, Furuse, Tamio, Kaneda, Hideki, Kobayashi, Kimio, Masuya, Hiroshi, Miura, Ikuo, Obata, Yuichi, Suzuki, Tomohiro, Tamura, Masaru, Tanaka, Nobuhiko, Yamada, Ikuko, Yoshiki, Atsushi, Berberovic, Zorana, Bubshait, Mohammed, Cabezas, Jorge, Carroll, Tracy, Clark, Greg, Clarke, Shannon, Creighton, Amie, Danisment, Ozge, Eskandarian, Mohammad, Feugas, Patricia, Gertsenstein, Marina, Guo, Ruolin, Hunter, Jane, Jacob, Elsa, Lan, Qing, Laurin, Valerie, Law, Napoleon, MacMaster, Sue, Miller, David, Morikawa, Lily, Newbigging, Susan, Owen, Celeste, Penton, Patricia, Pereira, Monica, Qu, Dawei, Shang, Xueyuan, Sleep, Gillian, Sohel, Khondoker, Tondat, Sandra, Wang, Yanchun, Vukobradovic, Igor, Zhu, Yingchun, Chiani, Francesco, Di Pietro, Chiara, Di Segni, Gianfranco, Ermakova, Olga, Ferrara, Filomena, Fruscoloni, Paolo, Gambadoro, Aalessia, Gastaldi, Serena, Golini, Elisabetta, Sala, Gina La, Mandillo, Silvia, Marazziti, Daniela, Massimi, Marzia, Matteoni, Rafaele, Orsini, Tiziana, Pasquini, Miriam, Raspa, Marcello, Rauch, Aline, Rossi, Gianfranco, Rossi, Nicoletta, Putti, Sabrina, Scavizzi, Ferdinando, Tocchini-Valentini, Giuseppe D., Beig, Joachim, Bürger, Antje, Giesert, Florian, Graw, Jochen, Kühn, Ralf, Oritz, Oskar, Schick, Joel, Seisenberger, Claudia, Amarie, Oana, Garrett, Lillian, Hölter, Sabine M., Zimprich, Annemarie, Aguilar-Pimentel, Antonio, Beckers, Johannes, Brommage, Robert, Calzada-Wack, Julia, Fuchs, Helmut, Gailus-Durner, Valérie, Lengger, Christoph, Leuchtenberger, Stefanie, Maier, Holger, Marschall, Susan, Moreth, Kristin, Neff, Frauke, Östereicher, Manuela A., Rozman, Jan, Steinkamp, Ralph, Stoeger, Claudia, Treise, Irina, Stoeger, Tobias, Yildrim, Ali Önder, Eickelberg, Oliver, Becker, Lore, Klopstock, Thomas, Ollert, Markus, Busch, Dirk H., Schmidt-Weber, Carsten, Bekeredjian, Raffi, Zimmer, Andreas, Rathkolb, Birgit, Wolf, Eckhard, Klingenspor, Martin, Tocchini-Valentini, Glauco P., Gao, Xiang, Bradley, Allan, Skarnes, William C., Moore, Mark, Beaudet, Arthur L., Justice, Monica J., Seavitt, John, Dickinson, Mary E., Wurst, Wolfgang, De Angelis, Martin Hrabe, Herault, Yann, Wakana, Shigeharu, Nutter, Lauryl M.J., Flenniken, Ann M., McKerlie, Colin, Murray, Stephen A., Svenson, Karen L., Braun, Robert E., West, David B., Lloyd, K. C.Kent, Adams, David J., White, Jacqui, Karp, Natasha, Flicek, Paul, Smedley, Damian, Meehan, Terrence F., Parkinson, Helen E., Teboul, Lydia M., Wells, Sara, Steel, Karen P., Mallon, Ann Marie, Brown, Steve D.M., Mason, Jeremy [0000-0002-2796-5123], de Angelis, Martin Hrabe [0000-0002-7898-2353], Herault, Yann [0000-0001-7049-6900], Wakana, Shigeharu [0000-0001-8532-0924], McKerlie, Colin [0000-0002-2232-0967], Lloyd, KC Kent [0000-0002-5318-4144], Flicek, Paul [0000-0002-3897-7955], Smedley, Damian [0000-0002-5836-9850], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Cancer Research, Candidate gene, General Physics and Astronomy, Datasets as Topic, Mice, 2.1 Biological and endogenous factors, Protein Interaction Maps, Aetiology, lcsh:Science, Pediatric, Genetics, Mice, Knockout, Multidisciplinary, medicine.diagnostic_test, Hearing Tests, Ear, Phenotype, medicine.anatomical_structure, Technology Platforms, International Mouse Phenotyping Consortium, medicine.symptom, Biotechnology, Hearing Loss/epidemiology, Hearing loss, Knockout, 1.1 Normal biological development and functioning, Science, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Clinical Research, Underpinning research, medicine, otorhinolaryngologic diseases, Auditory system, Animals, Genetic Testing, IMPC, mouse, auditory dysfunction, Set (psychology), Hearing Loss, Gene, Genetic testing, Auditory dysfunction, Human Genome, General Chemistry, 030104 developmental biology, Protein Interaction Maps/genetics, lcsh:Q
Abstract

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function., The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

Published
2017
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4. Impact of Delivery Room Resuscitation on Outcomes up to 18 Months in Very Low Birth Weight Infants

Author

Petra S. Hüppi, Henry Halliday, Markus Van der Hoeven, Thomas Ringstedt, Riccardo Pfister, Aida Bairam, Martin Offringa, Petra Hüppi, Eric Herlenius, Amsterdam Public Health, Other Research, Neonatology, Kindergeneeskunde, and RS: GROW - School for Oncology and Reproduction

Subjects
Male, Resuscitation, Hearing Loss/epidemiology, medicine.medical_treatment, Developmental Disabilities, Brain Injuries/epidemiology, Cerebral palsy, Retinopathy of Prematurity/epidemiology, Enterocolitis, Necrotizing, Infant Mortality, medicine, Intubation, Intratracheal, Humans, Infant, Very Low Birth Weight, Retinopathy of Prematurity, Cardiopulmonary resuscitation, Continuous positive airway pressure, Hearing Loss, Apnea of prematurity, Bronchopulmonary Dysplasia/epidemiology, Bronchopulmonary Dysplasia, ddc:618, Cardiopulmonary Resuscitation/adverse effects, business.industry, Cerebral Palsy, Delivery Rooms, Infant, Newborn, Masks, Retinopathy of prematurity, medicine.disease, Respiration, Artificial/adverse effects, Respiration, Artificial, Cardiopulmonary Resuscitation, Cerebral Palsy/epidemiology, Intubation, Intratracheal/adverse effects, Low birth weight, Bronchopulmonary dysplasia, Anesthesia, Brain Injuries, Pediatrics, Perinatology and Child Health, Multivariate Analysis, Female, medicine.symptom, business, Enterocolitis, Necrotizing/epidemiology, Infant, Premature, Developmental Disabilities/epidemiology
Abstract

Objective To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very low birth weight infants enrolled in the Caffeine for Apnea of Prematurity (CAP) Trial. Study design The CAP Trial enrolled 2006 infants with birthweights between 500 and 1250 g who were eligible for caffeine therapy. All levels of delivery room resuscitation were recorded in study participants. We divided infants in 4 groups of increasing intensity of resuscitation: minimal, n = 343; bag-mask ventilation, n = 372; endotracheal intubation, n = 1205; and cardiopulmonary resuscitation (chest compressions/epinephrine), n = 86. We used multivariable logistic regression models to compare outcomes across the 4 groups. Results The observed rates of death or disability, death, cerebral palsy, cognitive deficit, and hearing loss at 18 months increased with higher levels of resuscitation. Risk of bronchopulmonary dysplasia, severe retinopathy of prematurity, and brain injury also increased with higher levels of resuscitation. Adjustment for prognostic variables reduced the differences between the groups for most outcomes. Only the adjusted rates of bronchopulmonary dysplasia and severe retinopathy remained significantly higher after more intense resuscitation. Conclusions In CAP Trial participants, the risk of death or neurodevelopmental disability at 18 months did not increase substantially with increasing intensity of delivery room resuscitation.

Published
2011

5. Three cases of hearing loss related to mumps during a nationwide outbreak in the Netherlands, 2009-2013

Author

Vedat Topsakal, Susan Hahné, Rob van Binnendijk, Bert A Wolters, Ewout Fanoy, Jan van der Borden, Surgical clinical sciences, and Ear, nose & throat

Subjects
Microbiology (medical), Adult, Male, medicine.medical_specialty, Pediatrics, Adolescent, Hearing loss, Hearing Loss/epidemiology, MEDLINE, Netherlands/epidemiology, Disease Outbreaks, surgery, Epidemiology, medicine, Humans, Young adult, business.industry, Outbreak, Middle Aged, Mumps/complications, Vaccination, Infectious Diseases, Immunization, Otorhinolaryngology, Pediatrics, Perinatology and Child Health, young adult, Disease prevention, Female, medicine.symptom, business
Published
2014

6. Karyotype-specific ear and hearing problems in young adults with turner syndrome and the effect of oxandrolone treatment

Author

Dominique Smeets, Henri J L M Timmers, Vedat Topsakal, Sabine M.P.F. de Muinck Keizer-Schrama, Ronald J.E. Pennings, Ronald J.C. Admiraal, Jan M. Wit, Leonie A. Menke, K. Freriks, Henricus P. M. Kunst, Ad R. M. M. Hermus, Patrick L. M. Huygen, Theo C J Sas, Janiëlle A E M van Alfen-van der Velden, Eva J J Verver, Barto J. Otten, General Paediatrics, Amsterdam Reproduction & Development (AR&D), Surgical clinical sciences, and Ear, nose & throat

Subjects
Human Growth Hormone/administration & dosage, Pediatrics, Turner Syndrome/complications, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Sensory disorders Radboud Institute for Health Sciences [Radboudumc 12], Audiology, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], surgery, Oxandrolone, Anabolic Agents, Hearing, Turner syndrome, Cholesteatoma, Human Growth Hormone, Hearing Tests, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Sensory Systems, young adult, Sensorineural hearing loss, Drug Therapy, Combination, Female, medicine.symptom, Hearing Loss, Sensorineural/genetics, medicine.drug, Adult, medicine.medical_specialty, Monosomy, Adolescent, Hearing loss, Hearing Loss/epidemiology, Hearing Loss, Sensorineural, Oxandrolone/administration & dosage, Isochromosome, Karyotype, Other Research Donders Center for Medical Neuroscience [Radboudumc 0], Hearing impairment, Bone conduction, Double-Blind Method, medicine, otorhinolaryngologic diseases, Humans, Hearing Loss, business.industry, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Anabolic Agents/administration & dosage, medicine.disease, Otorhinolaryngology, Karyotyping, Neurology (clinical), business, Follow-Up Studies
Abstract

Item does not contain fulltext OBJECTIVE: To evaluate karyotype-specific ear and hearing problems in young-adult patients with Turner syndrome (TS) and assess the effects of previous treatment with oxandrolone (Ox). STUDY DESIGN: Double-blind follow-up study. SETTING: University hospital. PATIENTS: Sixty-five TS patients (mean age, 24.3 yr) previously treated with growth hormone combined with placebo, Ox 0.03 mg/kg per day, or Ox 0.06 mg/kg per day from the age of 8 years and estrogen from the age of 12 years. INTERVENTION: Ear examination was performed according to standard clinical practice. Air- and bone conduction thresholds were measured in decibel hearing level. MAIN OUTCOME MEASURES: We compared patients with total monosomy of the short arm of the X chromosome (Xp), monosomy 45,X and isochromosome 46,X,i(Xq), with patients with a partial monosomy Xp, mosaicism or other structural X chromosomal anomalies. We assessed the effect of previous Ox treatment. RESULTS: Sixty-six percent of the patients had a history of recurrent otitis media. We found hearing loss in 66% of the ears, including pure sensorineural hearing loss in 32%. Hearing thresholds in patients with a complete monosomy Xp were about 10 dB worse compared with those in patients with a partial monosomy Xp. Air- and bone conduction thresholds were not different between the placebo and Ox treatment groups. CONCLUSION: Young-adult TS individuals frequently have structural ear pathology, and many suffer from hearing loss. This indicates that careful follow-up to detect ear and hearing problems is necessary, especially for those with a monosomy 45,X or isochromosome 46,X,i(Xq). Ox does not seem to have an effect on hearing.

Published
2014

7. Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population

Author

Anke Tropitzsch, Hannie Kremer, Elina Mäki-Torkko, Cor W. R. J. Cremers, Thomas F. Wienker, Jan Hendrickx, Amalia Diaz-Lacava, Sylvia J. W. Kunst, Martti Sorri, Kelly Demeester, Erik Fransen, Joke Huyghe, Paul Van de Heyning, Patrick L. M. Huygen, Eva Orzan, Els Van Eyken, Guy Van Camp, Jeroen R. Huyghe, Angeles Espeso, Katja Verbruggen, Amanda Bonaconsa, Vedat Topsakal, Agnete Parving, Samuli Hannula, Michael Bille, Ingeborg Dhooge, Mona Jensen, Ilmari Pyykkö, Markus H F Pfister, Dafydd Stephens, Michael Steffens, Manuela Mazzoli, Lut Van Laer, Specialities, Surgical clinical sciences, Ear, nose & throat, Internal Medicine Specializations, and Cardio-vascular diseases

Subjects
Male, medicine.medical_specialty, Hearing Loss/epidemiology, Intraclass correlation, Presbycusis, DCN PAC - Perception action and control, Audiometry, Pure-Tone/statistics & numerical data, Audiology, Europe/epidemiology, surgery, medicine, Humans, statistics & numerical data [Audiometry, Pure-Tone], ddc:610, Hearing Loss, Aged, Auditory Threshold/physiology, Analysis of Variance, medicine.diagnostic_test, business.industry, Age Factors, Family aggregation, Auditory Threshold, epidemiology [Europe], Heritability, Middle Aged, medicine.disease, Genetics and epigenetic pathways of disease Plasticity and memory [NCMLS 6], Sensory Systems, Genetics and epigenetic pathways of disease DCN MP - Plasticity and memory [NCMLS 6], Europe, physiology [Auditory Threshold], Otorhinolaryngology, epidemiology [Hearing Loss], Audiometry, Pure-Tone, Sensorineural hearing loss, Female, Human medicine, Neurology (clinical), Analysis of variance, Pure tone audiometry, Audiometry, business
Abstract

Item does not contain fulltext OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated. STUDY DESIGN: Multicenter survey in 8 European centers. SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study. RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies. DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.

Published
2013
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8. Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: A European population-based multicenter study

Author

Minna Manninen, Michael Bille, Guy Van Camp, Elina Mäki-Torkko, Vedat Topsakal, Lut Van Laer, Anke Tropitzsch, Hannie Kremer, Nele Lemkens, Els Van Eyken, Martti Sorri, Jeroen R. Huyghe, Markus Pfister, Michael Steffens, Paul Van de Heyning, Ilmari Pyykkö, Manuela Mazzoli, Amalia Diaz-Lacava, Agnete Parving, Mona Jensen, Thomas F. Wienker, Cor W. R. J. Cremers, Sylvia J. W. Kunst, Eva Orzan, Samuli Hannula, Kelly Demeester, Dafydd Stephens, Joke Huyghe, Angeles Espeso, Katia Verbruggen, Ingeborg Dhooge, Patrick L. M. Huygen, Amanda Bonaconsa, Jan Hendrickx, Erik Fransen, Ear, nose & throat, Specialities, and Internal Medicine Specializations

Subjects
Male, medicine.medical_specialty, Alcohol Drinking, Hearing loss, Hearing Loss/epidemiology, Disease, Audiology, Affect (psychology), Article, smoking, surgery, Smoking/adverse effects, otorhinolaryngologic diseases, Medicine and Health Sciences, Medicine, Cluster Analysis, Humans, risk factors, Medical history, Hearing Loss, Body mass index, age-related hearing impairment, Aged, occupational noise, Noise, Occupational/adverse effects, business.industry, Smoking, Age Factors, life style, Middle Aged, medicine.disease, Obesity, Health Surveys, Sensory Systems, Europe, Multicenter study, Otorhinolaryngology, OBESITY, presbyacusis, Noise, Occupational, Female, medicine.symptom, business
Abstract

A multicenter study was set up to elucidate the environmental and medical risk factors contributing to age-related hearing impairment (ARHI). Nine subsamples, collected by nine audiological centers across Europe, added up to a total of 4,083 subjects between 53 and 67 years. Audiometric data (pure-tone average [PTA]) were collected and the participants filled out a questionnaire on environmental risk factors and medical history. People with a history of disease that could affect hearing were excluded. PTAs were adjusted for age and sex and tested for association with exposure to risk factors. Noise exposure was associated with a significant loss of hearing at high sound frequencies (>1 kHz). Smoking significantly increased high-frequency hearing loss, and the effect was dose-dependent. The effect of smoking remained significant when accounting for cardiovascular disease events. Taller people had better hearing on average with a more pronounced effect at low sound frequencies (

Published
2008

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