Search

BACKGROUND: Calciphylaxis is a calcifying arteriolopathy, on the other hand, perforating dermatosis are alterations in elastic fibers with degenerated basophilic collagen bundles. Both diseases are rare and usually seen in patients with stage V chronic kidney disease, mainly in woman in ages 40 to 60, with distribution in lower extremities. CLINICAL CASE: A 53-year-old female patient with history of systemic arterial hypertension, diabetes mellitus and chronic kidney disease, on renal replacement therapy with hemodialysis. Characterized by disseminated dermatosis to lower extremities affecting legs, consisting of necrotic ulcers of five months of evolution diagnosed as calciphylaxis. As well as a second dermatosis located to the left side of the neck, consisting of erythemato keratotic papules with central necrotic crust of two months of evolution, the histopathological study showed an acquired perforating dermatosis. CONCLUSIONS: The clinical case presented herein is a coexistence of both entities with a fatal outcome. The simultaneity of these diseases is rare, with few case reports. Both disorders have an impact on the quality of patients' lives, interfering with the medium-term prognosis of mortality. Therefore, its correct diagnosis and treatment are essential. It is believed that this association could have a relation with poor metabolic control of patients. [ABSTRACT FROM AUTHOR]

BACKGROUND: Pemphigus vulgaris is an autoimmune mucocutaneous disease resulting from the production of antidesmogleins against epidermal desmosomes. These autoantibodies produce blisters by acantholysis. Although pemphigus vulgaris frequently maintains its clinical expression, there is a poorly recognized percentage of patients that present alterations in their autoimmune profile and develop pemphigus foliaceous. CLINICAL CASE: A 25-year-old female patient with a 3-year history of pemphigus vulgaris in remission, who presented plaques with white oily scale on an erythematous base in seborrheic topography. The histopathological diagnosis was pemphigus foliaceus that showed clinical and histopathological transition from pemphigus vulgaris to pemphigus foliaceus. CONCLUSIONS: The clinical transition from pemphigus vulgaris to pemphigus foliaceus is a rare dermatological process of unknown etiology that correlates with the transition of anti-desmoglein 1 to anti-desmoglein 3 autoantibodies. Currently, information on this transition in Latin American patients is limited and highlights the importance of keeping the patient under surveillance. [ABSTRACT FROM AUTHOR]

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)