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21 results on '"Hierro-Oliva, Margarita"'

11. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity

Author

Peña González, Cornelia Emeritina, García Broncado, Pilar, Ottaviani, M. Francesca, Cangiotti, Michela, Fattori, Alberto, Hierro Oliva, Margarita, González Martín, M. Luisa, Pérez Serrano, Jorge, Gómez Ramírez, Rafael, Muñoz Fernández, María Ángeles, Sánchez-Nieves Fernández, Javier, Mata de la Mata, Francisco Javier de la, Universidad de Alcalá. Departamento de Biomedicina y Biotecnología, and Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica

Subjects
Chemistry, Antivirus agents, Sulfonate carbosilane dendrons, Gold nanoparticles, HIV, EPR, Química
Abstract

Anionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons., Ministerio de Economía y Empresa, Comunidad de Madrid, Universidad de Alcalá

Published
2016

13. Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion

Author

Córdoba, Alba, primary, Hierro-Oliva, Margarita, additional, Pacha-Olivenza, Miguel Ángel, additional, Fernández-Calderón, María Coronada, additional, Perelló, Joan, additional, Isern, Bernat, additional, González-Martín, María Luisa, additional, Monjo, Marta, additional, and Ramis, Joana M., additional

Published
2016
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14. On the interactions of human bone cells with Ti6Al4V thermally oxidized by means of laser shock processing

Author

Crespo, Lara, primary, Hierro-Oliva, Margarita, additional, Barriuso, Sandra, additional, Vadillo-Rodríguez, Virginia, additional, Montealegre, M Ángeles, additional, Saldaña, Laura, additional, Gomez-Barrena, Enrique, additional, González-Carrasco, José Luis, additional, González-Martín, María Luisa, additional, and Vilaboa, Nuria, additional

Published
2016
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16. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity

Author

Peña-González, Cornelia E., primary, García-Broncano, Pilar, additional, Ottaviani, M. Francesca, additional, Cangiotti, Michela, additional, Fattori, Alberto, additional, Hierro-Oliva, Margarita, additional, González-Martín, M. Luisa, additional, Pérez-Serrano, Jorge, additional, Gómez, Rafael, additional, Muñoz-Fernández, M. Ángeles, additional, Sánchez-Nieves, Javier, additional, and de la Mata, F. Javier, additional

Published
2016
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20. Experimental approach towards the water contact angle value on the biomaterial alloy Ti6Al4V.

Author

Bruque, Jose Morales, Hierro-Oliva, Margarita, Rodríguez-Cano, Abraham, Gallardo-Moreno, Amparo Maria, and González-Martín, Maria Luisa

Subjects
*TITANIUM alloys, *CONTACT angle, *MEDICINE, *WETTING, *CLEANING compounds
Abstract

In the biomedical field, water contact angle is a useful gauge to follow how a biomaterial surface would interact with the surrounding water-like physiological environment. Ti6Al4V alloy is widely used in orthopedic applications. Nevertheless, the values of its water contact angle reported in the literature show a large dispersion, from 40° up 80°. However, in addition to the expected dependence of the surface wettability on preliminary treatments, the values of the water contact angle on the pristine Ti6Al4V alloy suffers from an important variability and lack of reproducibility. The present research pays attention to this difficulty and proposes a simple experimental procedure to ensure adequate contact angle reproducibility. Controlled passivation growth in mild underwater conditions of freshly polished disks, followed by ultrasonic washing, avoiding the rubbing of the surface, gives average water contact angles of 80° with very low standard deviations also among samples from the same batch. [ABSTRACT FROM AUTHOR]

Published
2015
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21. Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity.

Author

Peña-González CE, García-Broncano P, Ottaviani MF, Cangiotti M, Fattori A, Hierro-Oliva M, González-Martín ML, Pérez-Serrano J, Gómez R, Muñoz-Fernández MÁ, Sánchez-Nieves J, and de la Mata FJ

Subjects
Antiviral Agents chemistry, Electron Spin Resonance Spectroscopy, Photoelectron Spectroscopy, Spectrophotometry, Ultraviolet, Anions chemistry, Antiviral Agents chemical synthesis, Antiviral Agents pharmacology, Dendrimers chemistry, Gold chemistry, HIV-1 chemistry, Metal Nanoparticles chemistry, Silanes chemistry
Abstract

Anionic carbosilane dendrons decorated with sulfonate functions and one thiol moiety at the focal point have been used to synthesize water-soluble gold nanoparticles (AuNPs) through the direct reaction of dendrons, gold precursor, and reducing agent in water, and also through a place-exchange reaction. These nanoparticles have been characterized by NMR spectroscopy, TEM, thermogravimetric analysis, X-ray photoelectron spectroscopy (XPS), UV/Vis spectroscopy, elemental analysis, and zeta-potential measurements. The interacting ability of the anionic sulfonate functions was investigated by EPR spectroscopy with copper(II) as a probe. Different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups for complexation by copper(II). Toxicity assays of AuNPs showed that those produced through direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher in the case of dendronized AuNPs than in dendrons., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2016
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