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3. Results of an interlaboratory study on the working curve in vat photopolymerization

Author

Kolibaba, T, Killgore, J, Caplins, B, Higgins, C, Arp, U, Miller, C, Poster, D, Zong, Y, Broce, S, Wang, T, Talacka, V, Andersson, J, Davenport, A, Panzer, M, Tumbleston, J, Gonzalez, J, Huffstetler, J, Lund, B, Billerbeck, K, Clay, A, Fratarcangeli, M, Qi, H, Porcincula, D, Bezek, L, Kikuta, K, Pearlson, M, Walker, D, Long, C, Hasa, E, Aguirre-Soto, A, Celis-Guzman, A, Backman, D, Sridhar, R, Cavicchi, K, Viereckl, R, Tong, E, Hansen, C, Shah, D, Kinane, C, Pena-Francesch, A, Antonini, C, Chaudhary, R, Muraca, G, Bensouda, Y, Zhang, Y, Zhao, X, Kolibaba T. J., Killgore J. P., Caplins B. W., Higgins C. I., Arp U., Miller C. C., Poster D. L., Zong Y., Broce S., Wang T., Talacka V., Andersson J., Davenport A., Panzer M. A., Tumbleston J. R., Gonzalez J. M., Huffstetler J., Lund B. R., Billerbeck K., Clay A. M., Fratarcangeli M. R., Qi H. J., Porcincula D. H., Bezek L. B., Kikuta K., Pearlson M. N., Walker D. A., Long C. J., Hasa E., Aguirre-Soto A., Celis-Guzman A., Backman D. E., Sridhar R. L., Cavicchi K. A., Viereckl R. J., Tong E., Hansen C. J., Shah D. M., Kinane C., Pena-Francesch A., Antonini C., Chaudhary R., Muraca G., Bensouda Y., Zhang Y., Zhao X., Kolibaba, T, Killgore, J, Caplins, B, Higgins, C, Arp, U, Miller, C, Poster, D, Zong, Y, Broce, S, Wang, T, Talacka, V, Andersson, J, Davenport, A, Panzer, M, Tumbleston, J, Gonzalez, J, Huffstetler, J, Lund, B, Billerbeck, K, Clay, A, Fratarcangeli, M, Qi, H, Porcincula, D, Bezek, L, Kikuta, K, Pearlson, M, Walker, D, Long, C, Hasa, E, Aguirre-Soto, A, Celis-Guzman, A, Backman, D, Sridhar, R, Cavicchi, K, Viereckl, R, Tong, E, Hansen, C, Shah, D, Kinane, C, Pena-Francesch, A, Antonini, C, Chaudhary, R, Muraca, G, Bensouda, Y, Zhang, Y, Zhao, X, Kolibaba T. J., Killgore J. P., Caplins B. W., Higgins C. I., Arp U., Miller C. C., Poster D. L., Zong Y., Broce S., Wang T., Talacka V., Andersson J., Davenport A., Panzer M. A., Tumbleston J. R., Gonzalez J. M., Huffstetler J., Lund B. R., Billerbeck K., Clay A. M., Fratarcangeli M. R., Qi H. J., Porcincula D. H., Bezek L. B., Kikuta K., Pearlson M. N., Walker D. A., Long C. J., Hasa E., Aguirre-Soto A., Celis-Guzman A., Backman D. E., Sridhar R. L., Cavicchi K. A., Viereckl R. J., Tong E., Hansen C. J., Shah D. M., Kinane C., Pena-Francesch A., Antonini C., Chaudhary R., Muraca G., Bensouda Y., Zhang Y., and Zhao X.

Abstract

The working curve informs resin properties and print parameters for stereolithography, digital light processing, and other photopolymer additive manufacturing (PAM) technologies. First demonstrated in 1992, the working curve measurement of cure depth vs radiant exposure of light is now a foundational measurement in the field of PAM. Despite its widespread use in industry and academia, there is no formal method or procedure for performing the working curve measurement, raising questions about the utility of reported working curve parameters. Here, an interlaboratory study (ILS) is described in which 24 individual laboratories performed a working curve measurement on an aliquot from a single batch of PAM resin. The ILS reveals that there is enormous scatter in the working curve data and the key fit parameters derived from it. The measured depth of light penetration Dp varied by as much as 7x between participants, while the critical radiant exposure for gelation Ec varied by as much as 70x. This significant scatter is attributed to a lack of common procedure, variation in light engines, epistemic uncertainties from the Jacobs equation, and the use of measurement tools with insufficient precision. The ILS findings highlight an urgent need for procedural standardization and better hardware characterization in this rapidly growing field.

Published
2024

7. Joblessness and Lost Earnings after Acute Respiratory Distress Syndrome in a 1-Year National Multicenter Study

Author

Kamdar, Biren B, Huang, Minxuan, Dinglas, Victor D, Colantuoni, Elizabeth, von Wachter, Till M, Hopkins, Ramona O, Needham, Dale M, Hudson, L, Gundel, S, Hough, C, Neff, M, Sims, K, Ungar, A, Watkins, T, Steingrub, J, Tidswell, M, Braden, E, DeSouza, L, Kardos, C, Kozikowski, L, Ouellette, S, Guntupalli, K, Bandi, V, Pope, C, Ross, C, Brower, R, Fessler, H, Hager, D, Mendez-Tellez, P, Needham, D, Oakjones, K, Sevransky, J, Workneh, A, Shanholtz, C, Herr, D, Howes, H, Netzer, G, Rock, P, Sampaio, A, Titus, J, Sloane, P, Beck, T, Highfield, D, King, S, Lee, B, Bolouri, N, Wiedemann, HP, Ashton, RW, Culver, DA, Frederick, T, Guzman, JA, Komara, JJ, Reddy, AJ, Hejal, R, Andrews, M, Haney, D, Connors, AF, Lasalvia, S, Thornton, JD, Warren, EL, Moss, M, Burnham, EL, Gray, L, Maloney, J, Mealer, M, Douglas, I, Overdier, K, Thompson, K, Wolken, R, Frankel, S, McKeehan, J, Warner, ML, Bost, T, Higgins, C, Hodgin, K, MacIntyre, N, Brown, L, Cox, C, Gentile, M, Govert, J, Knudsen, N, Carson, S, Chang, L, Choudhury, S, Hall, W, Lanier, J, Wheeler, AP, Bernard, GR, Hays, M, Mogan, S, Rice, TW, Hite, RD, Harvey, A, Morris, PE, Ragusky, M, Wright, P, Groce, S, McLean, J, Overton, A, and Truwit, J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Lung, Rare Diseases, Acute Respiratory Distress Syndrome, Adult, Critical Illness, Employment, Female, Humans, Income, Longitudinal Studies, Male, Middle Aged, Respiratory Distress Syndrome, Survivors, Time Factors, Unemployment, United States, employment, intensive care unit, income, health insurance, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleFollowing acute respiratory distress syndrome (ARDS), joblessness is common but poorly understood.ObjectivesTo evaluate the timing of return to work after ARDS, and associated risk factors, lost earnings, and changes in healthcare coverage Methods: Over 12-month longitudinal follow-up, ARDS survivors from 43 U.S. ARDSNet hospitals provided employment and healthcare coverage data via structured telephone interviews. Factors associated with the timing of return to work were assessed using Fine and Gray regression analysis. Lost earnings were estimated using Bureau of Labor Statistics data.Measurements and main resultsOf 922 consenting survivors, 386 (42%) were employed before ARDS (56% male; mean ± SD age, 45 ± 13 yr), with seven dying by 12-month follow-up. Of 379 previously employed 12-month survivors, 166 (44%) were jobless at 12-month follow-up. Accounting for competing risks of death and retirement, half of enrolled and previously employed survivors returned to work by 13 weeks after hospital discharge, with 68% ever returning by 12 months. Delays in return to work were associated with longer hospitalization and older age among nonwhite survivors. Over 12-month follow-up, 274 (71%) survivors accrued lost earnings, averaging $26,949 ± $22,447 (60% of pre-ARDS annual earnings). Jobless survivors experienced a 14% (95% confidence interval, 5-22%; P = 0.002) absolute decrease in private health insurance (from 44% pre-ARDS) and a 16% (95% confidence interval, 7-24%; P

Published
2017

8. Starting and Scaling a Set-Based Design Method for a Maritime System of Systems: Designing a Modern Warship

Author

Page, J. E., Higgins, C. J., Seering, W. P., Page, J. E., Higgins, C. J., and Seering, W. P.

Abstract

International Design Conference - Design 2022, There has been a growing body of literature and use cases for set-based design since its introduction in the 80s. Few studies or use cases involve highly complex systems, though, except for the hallmark work regarding Toyota in the late 90s. Over the last three years, the US Navy used set-based methods to design a complex system of systems: a warship. Their experience provides insight into the scalability of the method and design management considerations relevant to the start of similar projects.

Published
2024

9. Probing Jovian Decametric Emission with the Long Wavelength Array Station 1

Author

Clarke, T. E., Higgins, C. A., Skarda, Jinhie, Imai, Kazumasa, Imai, Masafumi, Reyes, Francisco, Thieman, Jim, Jaeger, Ted, Schmitt, Henrique, Dalal, Nagini Paravastu, Dowell, Jayce, Ellingson, S. W., Hicks, Brian, Schinzel, Frank, and Taylor, G. B.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

New observations of Jupiter's decametric radio emissions have been made with the Long Wavelength Array Station 1 (LWA1) which is capable of making high quality observations as low as 11 MHz. Full Stokes parameters were determined for bandwidths of 16 MHz. Here we present the first LWA1 results for the study of six Io-related events at temporal resolutions as fine as 0.25 ms. LWA1 data show excellent spectral detail in Jovian DAM such as simultaneous left hand circular (LHC) and right hand circular (RHC) polarized Io-related arcs and source envelopes, modulation lane features, S-bursts structures, narrow band N-events, and interactions between S-bursts and N-events. The sensitivity of the LWA1 combined with the low radio frequency interference environment allow us to trace the start of the LHC Io-C source region to much earlier CMLIII than typically found in the literature. We find the Io-C starts as early as CMLIII = 230 degrees at frequencies near 11 MHz. This early start of the Io-C emission may be valuable for refining models of the emission mechanism. We also detect modulation lane structures that appear continuous across LHC and RHC emissions, suggesting that both polarizations may originate from the same hemisphere of Jupiter. We present a study of rare S-bursts detected during an Io-D event and show drift rates are consistent with those from other Io-related sources. Finally, S-N burst events are seen in high spectral and temporal resolution and our data strongly support the co-spatial origins of these events., Comment: 17 pages, 18 figures, two tables. Journal of Geophysical Research - Space Physics accepted

Published
2014
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12. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)

Author

Kuhn, J, Abe, J, Adkins, S, Alkhovsky, S, Avsic-Zupanc, T, Ayllon, M, Bahl, J, Balkema-Buschmann, A, Ballinger, M, Baranwal, V, Beer, M, Bejerman, N, Bergeron, E, Biedenkopf, N, Blair, C, Blasdell, K, Blouin, A, Bradfute, S, Briese, T, Brown, P, Buchholz, U, Buchmeier, M, Bukreyev, A, Burt, F, Buttner, C, Calisher, C, Cao, M, Casas, I, Chandran, K, Charrel, R, Chaturvedi, K, Chooi, K, Crane, A, Bo, E, de la Torre, J, de Souza, W, de Swart, R, Debat, H, Dheilly, N, Di Paola, N, Di Serio, F, Dietzgen, R, Digiaro, M, Drexler, J, Duprex, W, Durrwald, R, Easton, A, Elbeaino, T, Ergunay, K, Feng, G, Firth, A, Fooks, A, Formenty, P, Freitas-Astua, J, Gago-Zachert, S, Garcia, M, Garcia-Sastre, A, Garrison, A, Gaskin, T, Gong, W, Gonzalez, J, de Bellocq, J, Griffiths, A, Groschup, M, Gunther, I, Gunther, S, Hammond, J, Hasegawa, Y, Hayashi, K, Hepojoki, J, Higgins, C, Hongo, S, Horie, M, Hughes, H, Hume, A, Hyndman, T, Ikeda, K, Jiang, D, Jonson, G, Junglen, S, Klempa, B, Klingstrom, J, Kondo, H, Koonin, E, Krupovic, M, Kubota, K, Kurath, G, Laenen, L, Lambert, A, Li, J, Liu, R, Lukashevich, I, Macdiarmid, R, Maes, P, Marklewitz, M, Marshall, S, Marzano, S, Mccauley, J, Mirazimi, A, Muhlberger, E, Nabeshima, T, Naidu, R, Natsuaki, T, Navarro, B, Navarro, J, Neriya, Y, Netesov, S, Neumann, G, Nowotny, N, Nunes, M, Ochoa-Corona, F, Okada, T, Palacios, G, Pallas, V, Papa, A, Paraskevopoulou, S, Parrish, C, Pauvolid-Correa, A, Paweska, J, Perez, D, Pfaff, F, Plemper, R, Postler, T, Rabbidge, L, Radoshitzky, S, Ramos-Gonzalez, P, Rehanek, M, Resende, R, Reyes, C, Rodrigues, T, Romanowski, V, Rubbenstroth, D, Rubino, L, Runstadler, J, Sabanadzovic, S, Sadiq, S, Salvato, M, Sasaya, T, Schwemmle, M, Sharpe, S, Shi, M, Shimomoto, Y, Sidharthan, V, Sironi, M, Smither, S, Song, J, Spann, K, Spengler, J, Stenglein, M, Takada, A, Takeyama, S, Tatara, A, Tesh, R, Thornburg, N, Tian, X, Tischler, N, Tomitaka, Y, Tomonaga, K, Tordo, N, Tu, C, Turina, M, Tzanetakis, I, Vaira, A, van den Hoogen, B, Vanmechelen, B, Vasilakis, N, Verbeek, M, von Bargen, S, Wada, J, Wahl, V, Walker, P, Waltzek, T, Whitfield, A, Wolf, Y, Xia, H, Xylogianni, E, Yanagisawa, H, Yano, K, Ye, G, Yuan, Z, Zerbini, F, Zhang, G, Zhang, S, Zhang, Y, Zhao, L, Okland, A, Kuhn J. H., Abe J., Adkins S., Alkhovsky S. V., Avsic-Zupanc T., Ayllon M. A., Bahl J., Balkema-Buschmann A., Ballinger M. J., Baranwal V. K., Beer M., Bejerman N., Bergeron E., Biedenkopf N., Blair C. D., Blasdell K. R., Blouin A. G., Bradfute S. B., Briese T., Brown P. A., Buchholz U. J., Buchmeier M. J., Bukreyev A., Burt F., Buttner C., Calisher C. H., Cao M., Casas I., Chandran K., Charrel R. N., Chaturvedi K. K., Chooi K. M., Crane A., Bo E. D., de la Torre J. C., de Souza W. M., de Swart R. L., Debat H., Dheilly N. M., Di Paola N., Di Serio F., Dietzgen R. G., Digiaro M., Drexler J. F., Duprex W. P., Durrwald R., Easton A. J., Elbeaino T., Ergunay K., Feng G., Firth A. E., Fooks A. R., Formenty P. B. H., Freitas-Astua J., Gago-Zachert S., Garcia M. L., Garcia-Sastre A., Garrison A. R., Gaskin T. R., Gong W., Gonzalez J. -P. J., de Bellocq J., Griffiths A., Groschup M. H., Gunther I., Gunther S., Hammond J., Hasegawa Y., Hayashi K., Hepojoki J., Higgins C. M., Hongo S., Horie M., Hughes H. R., Hume A. J., Hyndman T. H., Ikeda K., Jiang D., Jonson G. B., Junglen S., Klempa B., Klingstrom J., Kondo H., Koonin E. V., Krupovic M., Kubota K., Kurath G., Laenen L., Lambert A. J., Li J., Li J. -M., Liu R., Lukashevich I. S., MacDiarmid R. M., Maes P., Marklewitz M., Marshall S. H., Marzano S. -Y. L., McCauley J. W., Mirazimi A., Muhlberger E., Nabeshima T., Naidu R., Natsuaki T., Navarro B., Navarro J. A., Neriya Y., Netesov S. V., Neumann G., Nowotny N., Nunes M. R. T., Ochoa-Corona F. M., Okada T., Palacios G., Pallas V., Papa A., Paraskevopoulou S., Parrish C. R., Pauvolid-Correa A., Paweska J. T., Perez D. R., Pfaff F., Plemper R. K., Postler T. S., Rabbidge L. O., Radoshitzky S. R., Ramos-Gonzalez P. L., Rehanek M., Resende R. O., Reyes C. A., Rodrigues T. C. S., Romanowski V., Rubbenstroth D., Rubino L., Runstadler J. A., Sabanadzovic S., Sadiq S., Salvato M. S., Sasaya T., Schwemmle M., Sharpe S. R., Shi M., Shimomoto Y., Sidharthan V. K., Sironi M., Smither S., Song J. -W., Spann K. M., Spengler J. R., Stenglein M. D., Takada A., Takeyama S., Tatara A., Tesh R. B., Thornburg N. J., Tian X., Tischler N. D., Tomitaka Y., Tomonaga K., Tordo N., Tu C., Turina M., Tzanetakis I. E., Vaira A. M., van den Hoogen B., Vanmechelen B., Vasilakis N., Verbeek M., von Bargen S., Wada J., Wahl V., Walker P. J., Waltzek T. B., Whitfield A. E., Wolf Y. I., Xia H., Xylogianni E., Yanagisawa H., Yano K., Ye G., Yuan Z., Zerbini F. M., Zhang G., Zhang S., Zhang Y. -Z., Zhao L., Okland A. L., Kuhn, J, Abe, J, Adkins, S, Alkhovsky, S, Avsic-Zupanc, T, Ayllon, M, Bahl, J, Balkema-Buschmann, A, Ballinger, M, Baranwal, V, Beer, M, Bejerman, N, Bergeron, E, Biedenkopf, N, Blair, C, Blasdell, K, Blouin, A, Bradfute, S, Briese, T, Brown, P, Buchholz, U, Buchmeier, M, Bukreyev, A, Burt, F, Buttner, C, Calisher, C, Cao, M, Casas, I, Chandran, K, Charrel, R, Chaturvedi, K, Chooi, K, Crane, A, Bo, E, de la Torre, J, de Souza, W, de Swart, R, Debat, H, Dheilly, N, Di Paola, N, Di Serio, F, Dietzgen, R, Digiaro, M, Drexler, J, Duprex, W, Durrwald, R, Easton, A, Elbeaino, T, Ergunay, K, Feng, G, Firth, A, Fooks, A, Formenty, P, Freitas-Astua, J, Gago-Zachert, S, Garcia, M, Garcia-Sastre, A, Garrison, A, Gaskin, T, Gong, W, Gonzalez, J, de Bellocq, J, Griffiths, A, Groschup, M, Gunther, I, Gunther, S, Hammond, J, Hasegawa, Y, Hayashi, K, Hepojoki, J, Higgins, C, Hongo, S, Horie, M, Hughes, H, Hume, A, Hyndman, T, Ikeda, K, Jiang, D, Jonson, G, Junglen, S, Klempa, B, Klingstrom, J, Kondo, H, Koonin, E, Krupovic, M, Kubota, K, Kurath, G, Laenen, L, Lambert, A, Li, J, Liu, R, Lukashevich, I, Macdiarmid, R, Maes, P, Marklewitz, M, Marshall, S, Marzano, S, Mccauley, J, Mirazimi, A, Muhlberger, E, Nabeshima, T, Naidu, R, Natsuaki, T, Navarro, B, Navarro, J, Neriya, Y, Netesov, S, Neumann, G, Nowotny, N, Nunes, M, Ochoa-Corona, F, Okada, T, Palacios, G, Pallas, V, Papa, A, Paraskevopoulou, S, Parrish, C, Pauvolid-Correa, A, Paweska, J, Perez, D, Pfaff, F, Plemper, R, Postler, T, Rabbidge, L, Radoshitzky, S, Ramos-Gonzalez, P, Rehanek, M, Resende, R, Reyes, C, Rodrigues, T, Romanowski, V, Rubbenstroth, D, Rubino, L, Runstadler, J, Sabanadzovic, S, Sadiq, S, Salvato, M, Sasaya, T, Schwemmle, M, Sharpe, S, Shi, M, Shimomoto, Y, Sidharthan, V, Sironi, M, Smither, S, Song, J, Spann, K, Spengler, J, Stenglein, M, Takada, A, Takeyama, S, Tatara, A, Tesh, R, Thornburg, N, Tian, X, Tischler, N, Tomitaka, Y, Tomonaga, K, Tordo, N, Tu, C, Turina, M, Tzanetakis, I, Vaira, A, van den Hoogen, B, Vanmechelen, B, Vasilakis, N, Verbeek, M, von Bargen, S, Wada, J, Wahl, V, Walker, P, Waltzek, T, Whitfield, A, Wolf, Y, Xia, H, Xylogianni, E, Yanagisawa, H, Yano, K, Ye, G, Yuan, Z, Zerbini, F, Zhang, G, Zhang, S, Zhang, Y, Zhao, L, Okland, A, Kuhn J. H., Abe J., Adkins S., Alkhovsky S. V., Avsic-Zupanc T., Ayllon M. A., Bahl J., Balkema-Buschmann A., Ballinger M. J., Baranwal V. K., Beer M., Bejerman N., Bergeron E., Biedenkopf N., Blair C. D., Blasdell K. R., Blouin A. G., Bradfute S. B., Briese T., Brown P. A., Buchholz U. J., Buchmeier M. J., Bukreyev A., Burt F., Buttner C., Calisher C. H., Cao M., Casas I., Chandran K., Charrel R. N., Chaturvedi K. K., Chooi K. M., Crane A., Bo E. D., de la Torre J. C., de Souza W. M., de Swart R. L., Debat H., Dheilly N. M., Di Paola N., Di Serio F., Dietzgen R. G., Digiaro M., Drexler J. F., Duprex W. P., Durrwald R., Easton A. J., Elbeaino T., Ergunay K., Feng G., Firth A. E., Fooks A. R., Formenty P. B. H., Freitas-Astua J., Gago-Zachert S., Garcia M. L., Garcia-Sastre A., Garrison A. R., Gaskin T. R., Gong W., Gonzalez J. -P. J., de Bellocq J., Griffiths A., Groschup M. H., Gunther I., Gunther S., Hammond J., Hasegawa Y., Hayashi K., Hepojoki J., Higgins C. M., Hongo S., Horie M., Hughes H. R., Hume A. J., Hyndman T. H., Ikeda K., Jiang D., Jonson G. B., Junglen S., Klempa B., Klingstrom J., Kondo H., Koonin E. V., Krupovic M., Kubota K., Kurath G., Laenen L., Lambert A. J., Li J., Li J. -M., Liu R., Lukashevich I. S., MacDiarmid R. M., Maes P., Marklewitz M., Marshall S. H., Marzano S. -Y. L., McCauley J. W., Mirazimi A., Muhlberger E., Nabeshima T., Naidu R., Natsuaki T., Navarro B., Navarro J. A., Neriya Y., Netesov S. V., Neumann G., Nowotny N., Nunes M. R. T., Ochoa-Corona F. M., Okada T., Palacios G., Pallas V., Papa A., Paraskevopoulou S., Parrish C. R., Pauvolid-Correa A., Paweska J. T., Perez D. R., Pfaff F., Plemper R. K., Postler T. S., Rabbidge L. O., Radoshitzky S. R., Ramos-Gonzalez P. L., Rehanek M., Resende R. O., Reyes C. A., Rodrigues T. C. S., Romanowski V., Rubbenstroth D., Rubino L., Runstadler J. A., Sabanadzovic S., Sadiq S., Salvato M. S., Sasaya T., Schwemmle M., Sharpe S. R., Shi M., Shimomoto Y., Sidharthan V. K., Sironi M., Smither S., Song J. -W., Spann K. M., Spengler J. R., Stenglein M. D., Takada A., Takeyama S., Tatara A., Tesh R. B., Thornburg N. J., Tian X., Tischler N. D., Tomitaka Y., Tomonaga K., Tordo N., Tu C., Turina M., Tzanetakis I. E., Vaira A. M., van den Hoogen B., Vanmechelen B., Vasilakis N., Verbeek M., von Bargen S., Wada J., Wahl V., Walker P. J., Waltzek T. B., Whitfield A. E., Wolf Y. I., Xia H., Xylogianni E., Yanagisawa H., Yano K., Ye G., Yuan Z., Zerbini F. M., Zhang G., Zhang S., Zhang Y. -Z., Zhao L., and Okland A. L.

Abstract

In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV

Published
2023

13. Low-intensity late gadolinium enhancement predominates in hypertrophic cardiomyopathy

Author

Naeger, DM, Higgins, C, De Marco, T, Muzzarelli, S, and Ordovas, KG

Subjects
Nuclear Medicine & Medical Imaging, Clinical Sciences
Abstract

Aim: Assess the extent of low- versus high-intensity late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM). Methods: Low- versus high-intensity LGE indexed volumes in 19 HCM patients were compared to 23 myocardial infarction (MI) patients. Results: Total, low-, and high-intensity LGE volumes in HCM vs. MI were 7.6 ml/m2, 4.7, and 2.4 vs. 11.2, 2.5, and 7.1, respectively. Total LGE volume did not differ (P=13), though low- and high-intensity did (P=05, .004). 67% versus 26% of all LGE was low-intensity in HCM versus MI (P

Published
2015

14. Defining Production and Financial Data Streams Required for a Factory Digital Twin to Optimise the Deployment of Labour

Author

Taylor, C., Murphy, A., Butterfield, J., Jan, Y., Higgins, P., Collins, R., Higgins, C., Barbosa, Simone Diniz Junqueira, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Wang, Shilong, editor, Price, Mark, editor, Lim, Ming K., editor, Jin, Yan, editor, Luo, Yuanxin, editor, and Chen, Rui, editor

Published
2018
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16. Time-varying volatility and the housing market.

Author

Higgins, C. Richard and Sapci, Ayse

Subjects
HOUSING market, HOME prices, HOUSING, GREAT Recession, 2008-2013, CAPITAL costs, MONETARY policy, VOLATILITY (Securities)
Abstract

This paper studies the role of stochastic volatility in a setting where housing serves as an important propagation mechanism. After showing time-varying volatility in US house prices, we estimate a dynamic stochastic general equilibrium model with housing, financial frictions, and stochastic volatility using a nonlinear approximation and Bayesian econometric techniques. Incorporating stochastic volatility into the model greatly improves model fit and accounts for approximately half of the increased volatility in house prices observed during the Great Recession. Increased stochastic volatility escalates uncertainty which has significant effects on macroeconomic variables. While uncertainty in most sectors has negative effects on the economy, uncertainty on collateral constraints has the largest role. Unlike other uncertainty shocks, the housing demand uncertainty creates positive spillovers in the economy. Credit conditions, adjustment costs of capital and housing, and monetary policy are important transmission mechanisms for the stochastic volatility shocks. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

Author

Tanaka, T, Serneo, F F, Higgins, C, Gambello, M J, Wynshaw-Boris, A, and Gleeson, J G

Subjects
migration, Lis 1, doublecortin, centrosome, nucleus
Abstract

Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro neuronal migration assays with retroviral transduction. Overexpression of wild-type Dcx or Lis1, but not patient-related mutant versions, increased migration rates. Dcx overexpression rescued the migration defect in Lis1(+/-) neurons. Lis1 localized predominantly to the centrosome, and after disruption of microtubules, redistributed to the perinuclear region. Dcx outlined microtubules extending from the perinuclear "cage" to the centrosome. Lis1(+/-) neurons displayed increased and more variable separation between the nucleus and the preceding centrosome during migration. Dynein inhibition resulted in similar defects in both nucleus-centrosome (N-C) coupling and neuronal migration. These N-C coupling defects were rescued by Dcx overexpression, and Dcx was found to complex with dynein. These data indicate Lis1 and Dcx function with dynein to mediate N-C coupling during migration, and suggest defects in this coupling may contribute to migration defects in lissencephaly.

Published
2004

30. Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancers excludes additional high-impact susceptibility genes

Author

Loveday, C., primary, Garrett, A., additional, Law, P., additional, Hanks, S., additional, Poyastro-Pearson, E., additional, Adlard, J.W., additional, Barwell, J., additional, Berg, J., additional, Brady, A.F., additional, Brewer, C., additional, Chapman, C., additional, Cook, J., additional, Davidson, R., additional, Donaldson, A., additional, Douglas, F., additional, Greenhalgh, L., additional, Henderson, A., additional, Izatt, L., additional, Kumar, A., additional, Lalloo, F., additional, Miedzybrodzka, Z., additional, Morrison, P.J., additional, Paterson, J., additional, Porteous, M., additional, Rogers, M.T., additional, Walker, L., additional, Eccles, D., additional, Evans, D.G., additional, Snape, K., additional, Hanson, H., additional, Houlston, R.S., additional, Turnbull, C., additional, Ardern-Jones, A., additional, Adlard, J., additional, Ahmed, M., additional, Attard, G., additional, Bailey, K., additional, Bancroft, E., additional, Bardsley, C., additional, Barton, D., additional, Bartlett, M., additional, Baxter, L., additional, Belk, R., additional, Bernhard, B., additional, Bishop, T., additional, Boyes, L., additional, Bradshaw, N., additional, Brant, S., additional, Brice, G., additional, Bromilow, G., additional, Brooks, C., additional, Bruce, A., additional, Bulman, B., additional, Burgess, L., additional, Campbell, J., additional, Canham, N., additional, Castle, B., additional, Cetnarskyj, R., additional, Claber, O., additional, Coates, N., additional, Cole, T., additional, Collins, A., additional, Coulson, S., additional, Crawford, G., additional, Cruger, D., additional, Cummings, C., additional, D’Mello, L., additional, Day, L., additional, Dell, B., additional, Dolling, C., additional, Dorkins, H., additional, Downing, S., additional, Drummond, S., additional, Dubras, C., additional, Dunlop, J., additional, Durrell, S., additional, Eddy, C., additional, Edwards, M., additional, Edwards, E., additional, Edwardson, J., additional, Eeles, R., additional, Ellis, I., additional, Elmslie, F., additional, Evans, G., additional, Gibbons, B., additional, Gardiner, C., additional, Ghali, N., additional, Giblin, C., additional, Gibson, S., additional, Goff, S., additional, Goodman, S., additional, Goudie, D., additional, Grier, J., additional, Gregory, H., additional, Halliday, S., additional, Hardy, R., additional, Hartigan, C., additional, Heaton, T., additional, Higgins, C., additional, Hodgson, S., additional, Homfray, T., additional, Horrigan, D., additional, Houghton, C., additional, Hughes, L., additional, Hunt, V., additional, Irvine, L., additional, Jacobs, C., additional, James, S., additional, James, M., additional, Jeffers, L., additional, Jobson, I., additional, Jones, W., additional, Kennedy, M.J., additional, Kenwrick, S., additional, Kightley, C., additional, Kirk, C., additional, Kirk, E., additional, Kivuva, E., additional, Kohut, K., additional, Kosicka-Slawinska, M., additional, Kulkarni, A., additional, Lambord, N., additional, Langman, C., additional, Leonard, P., additional, Levene, S., additional, Locker, S., additional, Logan, P., additional, Longmuir, M., additional, Lucassen, A., additional, Lyus, V., additional, Magee, A., additional, Male, A., additional, Mansour, S., additional, McBride, D., additional, McCann, E., additional, McConnell, V., additional, McEntagart, M., additional, McKeown, C., additional, McLeish, L., additional, McLeod, D., additional, Melville, A., additional, Mercer, L., additional, Mercer, C., additional, Mitra, A., additional, Murday, V., additional, Murray, A., additional, Myhill, K., additional, Myring, J., additional, O'Hara, E., additional, Pearson, P., additional, Pichert, G., additional, Platt, K., additional, Pottinger, C., additional, Price, S., additional, Protheroe, L., additional, Pugh, S., additional, Quarrell, O., additional, Randhawa, K., additional, Riddick, C., additional, Robertson, L., additional, Robinson, A., additional, Roffey-Johnson, V., additional, Rogers, M., additional, Rose, S., additional, Rowe, S., additional, Schofield, A., additional, Rahman, N., additional, Saya, S., additional, Scott, G., additional, Scott, J., additional, Searle, A., additional, Shanley, S., additional, Sharif, S., additional, Shaw, A., additional, Shaw, J., additional, Shea-Simonds, J., additional, Side, L., additional, Sillibourne, J., additional, Simon, K., additional, Simpson, S., additional, Slater, S., additional, Smalley, S., additional, Smith, K., additional, Snadden, L., additional, Soloway, J., additional, Stait, Y., additional, Stayner, B., additional, Steel, M., additional, Steel, C., additional, Stewart, H., additional, Stirling, D., additional, Thomas, M., additional, Thomas, S., additional, Tomkins, S., additional, Turner, H., additional, Vandersteen, A., additional, Wakeling, E., additional, Waldrup, F., additional, Watt, C., additional, Watts, S., additional, Webber, A., additional, Whyte, C., additional, Wiggins, J., additional, Williams, E., additional, and Winchester, L., additional

Published
2022
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32. THE MATERHORN : Unraveling the Intricacies of Mountain Weather

Author

Fernando, H. J. S., Pardyjak, E. R., Di Sabatino, S., Chow, F. K., De Wekker, S. F. J., Hoch, S. W., Hacker, J., Pace, J. C., Pratt, T., Pu, Z., Steenburgh, W. J., Whiteman, C. D., Wang, Y., Zajic, D., Balsley, B., Dimitrova, R., Emmitt, G. D., Higgins, C. W., Hunt, J. C. R., Knievel, J. C., Lawrence, D., Liu, Y., Nadeau, D. F., Kit, E., Blomquist, B. W., Conry, P., Coppersmith, R. S., Creegan, E., Felton, M., Grachev, A., Gunawardena, N., Hang, C., Hocut, C. M., Huynh, G., Jeglum, M. E., Jensen, D., Kulandaivelu, V., Lehner, M., Leo, L. S., Liberzon, D., Massey, J. D., McEnerney, K., Pal, S., Price, T., Sghiatti, M., Silver, Z., Thompson, M., Zhang, H., and Zsedrovits, T.

Published
2015

33. SUPPLEMENT : THE MATERHORN Unraveling the Intricacies of Mountain Weather

Author

Fernando, H. J. S., Pardyjak, E. R., Di Sabatino, S., Chow, F. K., De Wekker, S. F. J., Hoch, S. W., Hacker, J., Pace, J. C., Pratt, T., Pu, Z., Steenburgh, J. W., Whiteman, C. D., Wang, Y., Zajic, D., Balsley, B., Dimitrova, R., Emmitt, G. D., Higgins, C. W., Hunt, J. C. R., Knievel, J. C., Lawrence, D., Liu, Y., Nadeau, D. F., Kit, E., Blomquist, B. W., Conry, P., Coppersmith, R. S., Creegan, E., Felton, M., Grachev, A., Gunawardena, N., Hang, C., Hocut, C. M., Huynh, G., Jeglum, M. E., Jensen, D., Kulandaivelu, V., Lehner, M., Leo, L. S., Liberzon, D., Massey, J. D., McEnerney, K., Pal, S., Price, T., Sghiatti, M., Silver, Z., Thompson, M., Zhang, H., and Zsedrovits, T.

Published
2015

43. The Role of the Unsteady Surface Wave-Driven Ekman–Stokes Flow in the Accumulation of Floating Marine Litter

Author

Cunningham, H. J. (author), Higgins, C. (author), van den Bremer, T.S. (author), Cunningham, H. J. (author), Higgins, C. (author), and van den Bremer, T.S. (author)

Abstract

Recently, a number of authors have used global particle tracking simulations to identify the effect that different surface currents have on marine litter accumulation, including the role of surface waves through the Stokes drift. However, in the upper-ocean boundary layer and in the presence of the Coriolis force, a wave-driven Eulerian flow forms that must be superimposed onto the Stokes drift in order to obtain the correct Lagrangian velocity. Taking into account both the Coriolis–Stokes force and the surface wave stress, Higgins et al. (2020), https://doi.org/10.1029/2020GL089189 derived an expression for this unsteady wave-driven Eulerian-mean flow in the form of a convolution between the Stokes drift and the so-called Ekman–Stokes kernel. In this paper, we apply this Ekman–Stokes kernel to generate a 12-year global hindcast of the wave-driven Eulerian current and show that its inclusion in particle tracking simulations has a significant effect on the distribution of small floating marine litter, such as microplastics. Using Lagrangian simulations, we find that the wave-driven Eulerian current is sensitive to the value of viscosity but generally opposes the dispersive behavior of the Stokes drift, reducing the amount of cross-Equator particle transport and transport to the polar regions, resulting in closer agreement between modeled and observed microplastic distributions., Environmental Fluid Mechanics

Published
2022
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44. Geography through the lens of intercultural learning: The changing nature of Australia and its impact on pedagogy

Author

Hu, B, Higgins, C, Hu, B, and Higgins, C

Abstract

We live in a connected world. For centuries our global connections were built through peoples’ movements and, more recently, by technology. In 2020, 281 million people lived outside their country of origin, and the average migrant stock in each country rose to 14 per cent from 9 per cent in 1990 (OECD, 2022). The combined acceleration of globalisation, technology and migration means that our global, national and local communities are more diverse than ever.

Published
2022

45. Educación en amabilidad para atender al otro

Author

Ruiz, J. A, Alexander, H. A, Balduzzi, E, Bernal Martinez de Soria, A, Higgins, C, Musaio, M, Naval, C, Villacis, J. L, Martín, A. P, Ibánez-Martín, J. A, Musaio, Marisa, Musaio, M (ORCID:0000-0003-1555-7314), Ruiz, J. A, Alexander, H. A, Balduzzi, E, Bernal Martinez de Soria, A, Higgins, C, Musaio, M, Naval, C, Villacis, J. L, Martín, A. P, Ibánez-Martín, J. A, Musaio, Marisa, and Musaio, M (ORCID:0000-0003-1555-7314)

Abstract

In a global emergency scenario, care and accompaniment for people have become central also in educational processes. The solicitude and the virtue of kindness manifest an educational meaning in Encyclical Fratelli di tutti by Pope Francis, an interesting document for elaborating pedagogical paths to educate an identity capable of caring for the other and to increase the experience of community and social friendship., En un escenario de emergencia mundial, el cuidado y acompañamiento de las personas se ha vuelto central también en los procesos educativos. La solicitud y la virtud de la amabilidad manifiestan un sentido educativo en la Encíclica Fratelli di tutti del Papa Francisco, un interesante documento para elaborar caminos pedagógicos para educar una identidad capaz de cuidar al otro y aumentar la experiencia de comunidad y amistad social.

Published
2022

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