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13 results on '"Hoff, Jessica S."'

3. In vitro serial passage of Staphylococcus aureus: changes in psysiology, virulence factor production, and agr nucleotide sequence

Author

Somerville, Greg A., Beres, Stephen B., Fitzgerald, J. Ross, DeLeo, Frank R., Cole, Robert L., Hoff, Jessica S., and Musser, James M.

Subjects
Bacteriology -- Research, Nucleotides -- Physiological aspects, Staphylococcus aureus -- Genetic aspects, Toxic shock syndrome -- Causes of, Biological sciences
Abstract

Research has been conducted on Staphylococcus aureus strains, recovered from the patient with toxic shock syndrome, which have high aconitase activity. The hypothesis that the aconitase specific activity decreases over time during the in vitro passage has been examined and the effect of the serial passage on the growth and virulence factor production has been investigated.

Published
2002

11. Genome sequence of a serotype M3 strain of group AStreptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence

Author

Beres, Stephen B., primary, Sylva, Gail L., additional, Barbian, Kent D., additional, Lei, Benfang, additional, Hoff, Jessica S., additional, Mammarella, Nicole D., additional, Liu, Meng-Yao, additional, Smoot, James C., additional, Porcella, Stephen F., additional, Parkins, Larye D., additional, Campbell, David S., additional, Smith, Todd M., additional, McCormick, John K., additional, Leung, Donald Y. M., additional, Schlievert, Patrick M., additional, and Musser, James M., additional

Published
2002
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12. Thymidylate Limitation Potentiates Cephalosporin Activity toward Enterococci viaan Exopolysaccharide-Based Mechanism

Author

Hoff, Jessica S. and Kristich, Christopher J.

Abstract

Multidrug resistant enterococci are major causes of nosocomial infections. Prior therapy with cephalosporins increases the risk of developing an enterococcal infection due to the intrinsic resistance of enterococci to these antibiotics. While progress has been made toward understanding the genetic and biochemical mechanisms of cephalosporin resistance, available data indicate that as-yet-unidentified resistance factors must exist. Here, we describe results of a screen to identify small molecules capable of sensitizing enterococci to broad-spectrum cephalosporins. We found that both Enterococcus faecalisand Enterococcus faeciumwere sensitized to broad and expanded-spectrum cephalosporins when thymidylate production was impaired, whether by direct inhibition of thymidylate synthase, or by limiting production of cofactors required for its activity. Cephalosporin potentiation is the result of altered exopolysaccharide production due to reduced dTDP-glucose synthesis. Hence, exopolysaccharide production is a previously undescribed contributor to the intrinsic cephalosporin resistance of enterococci and serves as a new target for antienterococcal therapeutics.

Published
2016
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13. In Vitro Serial Passage of Staphylococcus aureus: Changes in Physiology, Virulence Factor Production,a nd agr Nucleotide Sequence.

Author

Somerville, Greg A., Beres, Stephen B., Fitzgerald, J. Ross, DeLeo, Frank R., Cole, Robert L., Hoff, Jessica S., and Musser, James M.

Subjects
*PHENOTYPES, *STAPHYLOCOCCUS aureus, *GENES
Abstract

Examines the phenotypic and genotypic changes of Staphylococcus aureus during in vitro serial passage. Presence of aconitase activity in S. coccus strains; Influence of in vitro passage on acotinase specific activity; Regulation of beta-hemolytic activity by cell density-sensing accessory gene regulatory.

Published
2002
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