463 results on '"Hol, Wim G. J."'
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2. Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes
3. The Structure of p-Hydroxybenzoate Hydroxylase
4. E. Coli Heat Labile Enterotoxin and Cholera Toxin B-Pentamer—Crystallographic Studies of Biological Activity
5. Crystallographic Study of Eglin-C Binding to Thermitase
6. Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor
7. Assembly of Escherichia coli heat-labile enterotoxin and its secretion from Vibrio cholerae
8. A general protocol for the generation of Nanobodies for structural biology
9. Screening a fragment cocktail library using ultrafiltration
10. The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2
11. Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody
12. Structural Genomics of Pathogenic Protozoa: an Overview
13. Solid-phase synthesis of N-acyl-N'-alkyl/aryl disubstituted guanidines
14. In vivo cross-linking of EpsG to EpsL suggests a role for EpsL as an ATPase-pseudopilin coupling protein in the Type II secretion system of Vibrio cholerae
15. Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease
16. Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
17. Structural Basis for the Activation of Cholera Toxin by Human ARF6-GTP
18. In search of new lead compounds for trypanosomiasis drug design: A protein structure-based linked-fragment approach
19. Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins
20. Drugs to Combat Tropical Protozoan Parasites
21. E. Coli Heat Labile Enterotoxin and Cholera Toxin B-Pentamer—Crystallographic Studies of Biological Activity
22. Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
23. Protein structure-based design of anti-protozoal drugs
24. Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection
25. A Model for the Mechanism of Human Topoisomerase I
26. Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA
27. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation
28. Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity
29. Structure of the Heat Shock Protein Chaperonin-10 of Mycobacterium leprae
30. The crystal structure of the drug targetMycobacterium tuberculosismethionyl-tRNA synthetase in complex with a catalytic intermediate
31. Protein Crystallography and Drug Design
32. Three-Dimensional Structure of Haemocyanin from the Spiny Lobster, Panulirus Interruptus, at 3.2 Å Resolution
33. Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry
34. Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections
35. Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanismo
36. From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis
37. Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
38. 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors
39. The crystal structure of the drug target <italic>Mycobacterium tuberculosis</italic> methionyl‐tRNA synthetase in complex with a catalytic intermediate.
40. Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites
41. SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
42. A binding hotspot inTrypanosoma cruzihistidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens
43. Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future
44. Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness
45. Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy
46. High-affinity pentavalent ligands of Escherichia coli heat-labile enterotoxin by modular structure-based design
47. Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
48. Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold
49. Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target
50. Structure of a low-melting-temperature anti-cholera toxin: llama VHH domain
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