1. Melanoma arising from pre-existing naevus in carriers of a germline CDKN2A pathogenic variant.
- Author
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Rauwerdink, Daan J W, Hoogland, Yann, Schrader, Anne M R, Potjer, Thomas P, Kapiteijn, Ellen, Hage, Jos A van der, and Doorn, Remco van
- Subjects
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SUNSHINE , *ACADEMIC medical centers , *NEVUS , *MELANOMA diagnosis , *SAMPLING errors - Abstract
The article published in the British Journal of Dermatology explores the development of melanoma from pre-existing naevi in individuals with a germline CDKN2A pathogenic variant. The study found that 78% of melanomas in carriers of this variant originated from pre-existing naevi, with total-body photography being a useful tool for surveillance. The findings suggest the importance of routine monitoring and early detection in individuals with a CDKN2A pathogenic variant to prevent melanoma development. The study acknowledges limitations in sample size and patient demographics, emphasizing the need for further research in this area. [Extracted from the article]
- Published
- 2025
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