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The 1.7 kV 4H-SiC MOSFET which features optimized retrograded-profile ion implantation in the JFET regions (RG-MOS) is proposed and fabricated on the 4 inch wafers. The measured results quantify the benefits of the RG-MOS structure: simultaneous improvement in high-frequency figures of merit (HF-FOM) (R on× C GD) by 1.5×, HF-FOM (R on × Q GD) by 1.5× and Baliga figure of merit (BFOM = 4BV2/ R on,sp) by 1.6× compared with the conventional MOSFET (CON-MOS). Unlike other reported complicated structures which need high-precise fabricating process, the proposed RG-MOS structure is compatible with the prior planar 4H-SiC MOSFET process, and is favorable for large-scale production. [ABSTRACT FROM AUTHOR]

Increasing cadmium (Cd) pollution has negative effects on quinoa growth and production. Gamma-aminobutyric acid (GABA) confers plants with stress resistance to heavy metals; however, the mechanism remains unclear. We explored the effects of exogenous GABA on the physiological characteristics, antioxidant capacity, and Cd accumulation of quinoa seedlings under Cd stress using hydroponic experiments. Partial least-squares regression was used to identify key physical and chemical indices of seedlings affecting Cd accumulation. Compared with those of the CK group, exposure to 10 and 25 µmol · L-1 Cd significantly reduced the photosynthetic pigment contents, photosynthesis, and biomass accumulation of quinoa seedlings; resulted in shorter and thicker roots; decreased the length of the lateral roots; decreased the activities of superoxide dismutase (SOD) and peroxide (POD); and increased H2O2 and malondialdehyde (MDA) contents. Exogenous GABA reduced the Cd content in the stem/leaves and roots of quinoa seedlings under Cd stress by 13.22-21.63% and 7.92-28.32%, decreased Cd accumulation by 5.37-6.71% and 1.91-4.09%, decreased the H2O2 content by 38.21-47.46% and 45.81-55.73%, and decreased the MDA content by 37.65-48.12% and 29.87-32.51%, respectively. GABA addition increased the SOD and POD activities in the roots by 2.78-5.61% and 13.81-18.33%, respectively, under Cd stress. Thus, exogenous GABA can reduce the content and accumulation of Cd in quinoa seedlings by improving the photosynthetic characteristics and antioxidant enzyme activity and reducing the degree of lipid peroxidation in the cell membrane to alleviate the toxic effect of Cd stress on seedling growth. [ABSTRACT FROM AUTHOR]

Background: Platycladus orientalis leaves (POL), as the source of the traditional Chinese medicine (TCM) Platycladi Cacumen, has frequently been found to be misused with five adulterants including Chamaecyparis obtusa leaves (COL), Cupressus funebris leaves (CFL), Juniperus virginiana leaves (JVL), Sabina chinensis leaves (SCL), and Juniperus formosana leaves (JFL). Objective: The purpose of this study was to distinguish POL (fresh leaves) from its five adulterants (fresh leaves). Methods: The micromorphological features in terms of transection and microscopic characteristics of POL and adulterants were captured and compared using the an microscope. Both HPLC and TLC methods for the simultaneous determination of six bioactive flavonoids (myricitrin, isoquercitrin, quercitrin, amentoflavone, afzelin, and hinokiflavone) have been developed. Results: There were significant differences in microscopic features of transverse section and powders. The TLC results suggested that the spots of myricitrin in POL were more obvious than those in the five adulterants. The contents of myricitrin and quercitrin, or the total content of flavonoids in POL, determined by HPLC, were significantly higher than those in the adulterants. Conclusion: POL was successfully distinguished from its five adulterants by the comparison of morphology, microscopic characteristics, and chemical profiles. Highlights: This research provides a comprehensive morphology, microscopic identification, TLC, and HPLC analysis for authenticating POL and its five adulterants. [ABSTRACT FROM AUTHOR]

Background. Senescence is thought to be an imperative effect on the development of cancer. However, few studies pay an attention to the senescence-associated genes in pancreatic cancer (PC). The prognostic value of senescence-related genes (SRGs) and their involvement in tumor microenvironment (TME) in the PC remain obscure. The aim of this research was to investigate the prognostic role of senescence-associated genes and their affection in TME in PC. Methods. The transcriptome and clinical information of PC patients were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Two SRG-mediated molecular clusters were comprehensively identified. In total, data from the 285 PC patients were randomly used to develop a senescence-associated gene signature in the training set and verified in the validation set. Immune microenvironment analysis pertained to senescence-related genes was performed. Results. A SRG_score including five senescence-associated genes was established to separate PC patients into two risk groups. High-risk patients had worse overall survival than low-risk patients. The result of the multivariate Cox regression analysis identified the risk score and stage as independent prognostic factors for PC patients. Receiver operating characteristic curve (ROC) analysis confirmed the credible predictive ability of the nomogram. The area under time-dependent ROC curve (AUC) reached 0.746 at 1 year, 0.781 at 3 years, and 0.868 at 5 years in the training set and 0.653 at 1 year, 0.755 at 3 years, and 0.785 at 5 years in the validation set. Moreover, the SRG_score was associated with TME, tumor mutation burden (TMB), and chemotherapeutic drug sensitivity. Conclusions. This study found that the novel SRG_score could be an independent prognostic target for PC patients. Senescence-associated genes had a vital impact on the immune microenvironment and the treatment of PC patients. [ABSTRACT FROM AUTHOR]

Consequent-pole (CP) permanent magnet (PM) configuration suffers asymmetric electromagnetic characteristics although it saves PM usage. The CP-based stator-PM synchronous machines are investigated in this paper, with particular reference to symmetrical issues. The electromagnetic performances of the CP-based stator-PM synchronous machines are firstly evaluated. Afterwards, the rule of even order harmonics cancellation is presented for different slot/pole number combinations and winding layouts, based on which symmetrical phase flux-linkages can be obtained although the unbalanced magnetic flux naturally occurs. Moreover, based on the three-dimensional finite element analysis, the unipolar end leakage-flux caused by the asymmetric magnetic field is identified, and the risk of the shaft magnetization is revealed. Finally, a pair of prototype machines are fabricated and measured to validate the analyses. [ABSTRACT FROM AUTHOR]

A series of V-xCe/Ti catalysts was prepared by a step impregnation method with gradual increased Ce amount. Compared to the commercial V–W/Ti catalysts, the V-xCe/Ti catalysts exhibited considerably higher CO x selectivity during the oxidation of naphthalene (Nap), and less intermediates or by-products were detected both in gas phase and on the surface of the catalysts. Through a series of characterizations, it was found that abundance of weak basic sites in the form of OH was introduced by Ce, as well as the oxygen vacancies caused by the redox cycle of V4++Ce4+↔V5++Ce3+. The weak basic sites introduced by Ce could greatly enhance the Nap adsorption, and the Nap adsorbed was quickly converted to naphthol on Ce–OH. Furthermore, V existed at a high valence with the interaction of V and Ce, and the oxygen vacancies also increased the O ads and O OH. It improved the redox ability and the regeneration of Ce–OH on V-xCe/Ti catalysts. The intermediates could be further oxidized, and the Ce–OH consumed in the reaction could recover quickly. Therefore, almost 100% Nap conversion and a high CO x selectivity was observed in the V-xCe/Ti catalysts system. [Display omitted] • Ce introduced a lot of weak basic sites in the form of Ce–OH. • More naphthalene could adsorb and convert to naphthol on the weak basic sites. • V was kept at high valence and oxygen vacancies were produce through the interaction of Ce and V. • The intermediates during the naphthalene oxidation were further oxidized to enhance the CO x selectivity. [ABSTRACT FROM AUTHOR]

In this paper, an analytical method (AM) based on the air-gap magnetomotive force (MMF) permeance model is proposed to predict the nonlinear instantaneous torque of switched reluctance machines (SRMs). The analytical expression of the air-gap MMF is first obtained from the winding function and current profile, while the air-gap magnetic permeance considering the double-sided slotting effects is also derived. Then, the nonsaturated field distribution along the air-gap circumference is presented based on which the instantaneous torque can be calculated from the Lorentz force law. Furthermore, the model is enhanced with a saturation distribution factor to include the nonlinear characteristics. The proposed method is free from preliminary data or empirical coefficient and benefits from the simplified model and solution. The AM will be validated by the two-dimensional finite-element method based on four SRMs with different structures. Moreover, an SRM prototype is manufactured for experimental verification. [ABSTRACT FROM AUTHOR]

The even order harmonics of the flux linkage naturally exist in every armature coil of stator-permanent magnet (PM) machines, while it is usually a basic requirement to have the symmetrical phase flux linkage free from even order harmonics. Thus, the specific harmonics must be eliminated after the coil connection. In this article, the general mechanism of the even order harmonics elimination in various stator-PM machines is investigated, and it is found that either the opposite PM polarities or the opposite coil polarities of the two adjacent phase coils can guarantee the elimination effect, and hence, the symmetrical phase flux linkages. This principle can be applied to both bipolar flux and unipolar flux machines. The analysis is validated by finite-element method and the test results of the prototype machine. [ABSTRACT FROM AUTHOR]

The Erdős-Rényi (ER) random graph G(n, p) analytically characterizes the behaviors in complex networks. However, attempts to fit real-world observations need more sophisticated structures (e.g., multilayer networks), rules (e.g., Achlioptas processes), and projections onto geometric, social, or geographic spaces. The p-adic number system offers a natural representation of hierarchical organization of complex networks. The p-adic random graph interprets n as the cardinality of a set of p-adic numbers. Constructing a vast space of hierarchical structures is equivalent for combining number sequences. Although the giant component is vital in dynamic evolution of networks, the structure of multiple big components is also essential. Fitting the sizes of the few largest components to empirical data was rarely demonstrated. The p-adic ultrametric enables the ER model to simulate multiple big components from the observations of genetic interaction networks, social networks, and epidemics. Community structures lead to multimodal distributions of the big component sizes in networks, which have important implications in intervention of spreading processes. [ABSTRACT FROM AUTHOR]

Hybrid excited (HE) machines have the synergies of high torque density and high efficiency of permanent magnet (PM) machines and excellent flux controllability of wound-field machines. The PMs and field coils (FCs) coexist in HE machines to provide excitations simultaneously, and can be coupled either in series or parallel. The topologies of HE machines are very diverse, which bring challenges in the selection and design of HE machines. Based on the partitioned stator (PS) platform, a pair of series and parallel HE machines having similar structures and PM usage are evaluated and compared to identify their merits and demerits. With the help of finite element analysis, the flux regulation, energy conversion capability, parasitic effects and irreversible demagnetization of the two kinds of the HE machines are comprehensively investigated and the guidance to the machine design is provided. A pair of prototypes are fabricated and tested to validate the analyses. [ABSTRACT FROM AUTHOR]

The torque production mechanism of switched reluctance machines (SRMs) is investigated from the perspective of air-gap field modulation principle. The unipolar stator current excitations can be divided into DC and AC components and they induce the air-gap magneto-motive force (MMF) respectively. Meanwhile, thanks to the salient structure in SRMs, the air-gap MMFs induced by the two sources above can be modulated to obtain the synchronized air-gap fields for torque production. It is revealed that a multitude of field harmonics contribute to the torque together. The MMF-permeance model is built and the analytical deduction of the field modulation effect is provided, with which the orders of the field harmonics contributing to the torque output can be identified. Moreover, finite element method is employed to verify the predictions on various SRM topologies. Finally, aprototype machine is fabricated and measuredfor validation. [ABSTRACT FROM AUTHOR]

Ancherythroculter nigrocauda is a cyprinid fish endemic of the upper reaches of the Yangtze River in China, where it is an important aquaculture and commercial species. It is also a threatened species as a result of overfishing, dam construction and water pollution. In this study, a chromosome‐level genome assembly of A. nigrocauda is reported and built using PacBio sequencing and the Hi‐C technology. The 1.04‐Gb sequenced genome of A. nigrocauda contained 2,403 contigs, with an N50 length of 3.12 Mb. Then, 1,297 contigs, which represented 54.0% of all contigs and 97.2% of the whole content of the genome nucleotide base, were assembled into 24 chromosomes. Combined with transcriptome data from 10 tissues, 27,042 (78.5%) genes were functionally annotated out of 34,414 predicted protein‐coding genes. Interestingly, high expression of many positively selected genes and expanded gene families in the brain suggested that these genes might play important roles in brain development in A. nigrocauda. Finally, we found tissue‐specific expression of 10,732 genes. Functional analyses showed that they were mainly composed of genes related to (a) environmental information processing, (b) the circulatory system, and (c) development, suggesting they might be important for adaptation to different environments and for development of A. nigrocauda. The high‐quality genome obtained in this study not only provides a valuable genomic resource for future studies of A. nigrocauda populations and conservation, but is also an important resource for further functional genomics studies of fishes. [ABSTRACT FROM AUTHOR]

We introduce a variant of the timber grid shell, the timber Voronoi shell, whose surface is reticulated by Voronoi tessellation and whose edges are made of discrete dimensional timber. This work explores form-finding methods of the Voronoi shell as a compressive funicular shell. Two closed-form solutions to shape initialization are proposed. We develop methods for minimizing the deviation from coplanarity between timber members and adjacent surface normal in order to facilitate manufacturing. A well-defined fabrication process is important for making the physical structure consistent with the structural model. A 6-axis robot with a motor spindle is employed to prefabricate the timber so the in situ manual assembly becomes easier. A parametric model describes the joint details. We formulate the robotic toolpath as a closed-form function of the resultant mesh from form finding. Thus, a general-purpose programming language can directly implement the mesh optimization and manufacturing processes without CAD or CAM software. The physical implementations, including an exhibition pavilion, validated the approach. [ABSTRACT FROM AUTHOR]

BACKGROUND: Experimental studies have shown that disinfection byproducts (DBPs) including haloacetic acids (HAAs) can cause liver toxicity, but evidence linking this association in humans is sparse. OBJECTIVES: We aimed to explore the associations between HAA exposures and liver injury. METHODS: We included 922 women between December 2018 and January 2020 from the Tongji Reproductive and Environmental (TREE) cohort study in Wuhan, China. Urinary HAA concentrations including trichloroacetic acid (TCAA) and dichloroacetic acid (DCAA) and serum indicators of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were measured. Liver injury was defined as if any of serum indicator levels were above the 90th percentile. Multivariate logistic and linear regression models were fitted to assess the associations of urinary HAA concentrations with the risk of liver injury and liver function indicators. Stratified analyses by age, body mass index (BMI), alcohol use, and passive smoking were also applied to evaluate the potential effect modifiers. RESULTS: There is little evidence of associations of urinary TCAA concentrations with liver injury risk and liver function indicators. However, urinary DCAA concentrations were associated with a higher risk of liver injury [odds ratios (OR) for 1-interquartile range (IQR) increase in natural log (ln) transformed DCAA concentrations: 1.45; 95% confidence interval (CI): 1.07, 1.98]. This association was observed only among nondrinkers (푝interaction =0.058). We also found that a 1-IQR increase in ln-transformed DCAA concentrations was positively associated with ALT levels (percentage change =6.06%; 95% CI: 0.48%, 11.95%) and negatively associated with AST/ALT (percentage change= -4.48%; 95% CI: -7.80%, -1.04%). In addition, urinary DCAA concentrations in relation to higher GGT levels was observed only among passive smokers (푝interaction =0.040). CONCLUSION: Our findings suggest that exposure to DCAA but not TCAA is associated with liver injury among women undergoing assisted reproductive technology. [ABSTRACT FROM AUTHOR]

Hybrid permanent-magnet (PM) variable-flux memory (VFM) machines employ both high coercive force PM, i.e., the constant PM (CPM), and low coercive force PM, i.e., the variable PM (VPM). The high energy-product CPM guarantees the benefits of high torque density of the conventional PM machines, while the PM magnetization state of the VPM is flexibly regulated to match various operation requirements. In fact, the two kinds of PMs can be magnetically connected in either parallel or series, with which the machine characteristics are quite different. In this paper, based on the two-dimensional and three-dimensional finite-element analyses, a pair of VFM machines with parallel and series connections, respectively, are investigated with specific reference to identify their difference in end effects. The comparison results show that the series hybrid PM VFM machine suffers more serious end leakage flux. The prototype machines are manufactured and tested to validate the analyses and predictions. [ABSTRACT FROM AUTHOR]

We present a systematic method for producing double-sided minimal surfaces by wire-cut machines. A link between minimal surfaces and ruled surfaces is pursued through wire cutting. Weierstrass parameterization is employed to define minimal surfaces (R3) over a complex plane (C). Our method consists of three components. First, the orthogonal double-sided cuts match a pair of orthonormal tangent vectors on the surface. Second, A closed-form expression for the principal directions facilitates the global quadrangulation of minimal surfaces. Third, the CNC machine’s toolpath results from the surface’s analytic characterization. Asymptotic cutting and principal cutting are compared in terms of collisions and cutting error. We employed a general-purpose language (Java) to create machine instructions from the Weierstrass representation of minimal surfaces. Thus, the entire workflow from mathematical modeling to production involves no 3D models or CAD/CAM software. Both a 5-axis wire cutter and a customized robotic system were tested. [ABSTRACT FROM AUTHOR]

Purpose: To perform a qualitative and quantitative analysis of catechin and quercetin in flavonoids extracted from Rosa roxburghii Tratt. Methods: Total flavonoids were determined using ultraviolet spectrophotometry (UV) at 500 nm. The optimal gradient program started with 15 % methanol and was kept within a period of 0 - 20 min, while 25 % methanol was kept within 20 - 33 min. Subsequently, the concentration of methanol was reduced to 15 % and was held for 10 min until the next injection. Mass spectrometry spray voltage was 4,000 V, ionization temperature 350 °C, atomizer pressure 35 psi, nitrogen flow rate 8 L/min, and mass scan range 200 - 800 m/z. The detection wavelength used for catechin and quercetin was 270 and 368 nm, respectively. Results: Based on the UV results, Rosa roxburghii Tratt content was 73.85 %, which is in agreement with the national standard. Liquid chromatography-mass spectrometry (LC-MS) results indicate that Rosa roxburghii Tratt flavonoids contained quercetin, 34.26 %, with relative standard deviation (RSD) of 2.88 % and catechin content of 2.97 % with RSD of 1.49 %. Conclusion: The proposed measurement method for determining the content of flavonoids in Rosa roxburghii Tratt has the advantage of simplicity, feasibility, good repeatability, and rapid and accurate analysis. [ABSTRACT FROM AUTHOR]

A series hybrid variable flux memory (VFM) machine employing two kinds of permanent magnets (PMs) on alternate rotor poles is investigated. This VFM machine features controllable PM flux and thus good flux-weakening capability, as well as improved torque density. However, it is found that the unipolar end leakage flux occurs if the two kinds of PMs are not balanced. According to the analyses of series connection between two PMs based on the fundamental magnetic circuit, the mechanism of the unbalanced rotor poles and the unipolar end leakage flux is revealed. Further, the rule of obtaining balanced poles is identified and the effects of operating conditions are presented. A series hybrid VFM machine prototype is fabricated and tested. [ABSTRACT FROM AUTHOR]

This paper proposes a novel variable flux memory (VFM) machine, in which the “constant” permanent magnet (CPM) with high coercive force and the “variable” PM (VPM) with low coercive force are alternatively located in the interior-PM rotor. Thus, the VPMs and CPMs are magnetically connected in series, with which the CPMs can assist the VPMs to withstand the unintentional demagnetization caused by armature reaction. Therefore, a high armature current can be applied to the machine. Meanwhile, the reluctance torque is retrieved. Thus, a high torque density can be obtained. Based on two-dimensional finite element analysis, first, the electromagnetic performance of the proposed VFM machine in two extreme magnetization states is evaluated in detail. Then, the demagnetization and remagnetization characteristics are investigated, in which the working points of VPMs are illustrated. Furthermore, the advantages of improved efficiency of the proposed VFM machine are demonstrated. A prototype machine is manufactured and tested to validate the predictions. [ABSTRACT FROM AUTHOR]

A novel partitioned stator (PS) hybrid excited (HE) switched flux (SF) (PS-HESF) machine is proposed in this paper. In the PS-HESF machine, the permanent magnets (PMs) and field windings are allocated on one stator while the armature windings are placed on the other. The iron-piece-rotor is sandwiched between the two stators. Consequently, compared with the conventional HESF machine having PMs, field windings as well as armature windings all on one stator, the available space of the novel machine is greatly boosted and therefore the performance is enhanced. Based on 2-D finite-element analysis, the electromagnetic performance of the PS-HESF machine is evaluated and the results reveal that it can exhibit not only better flux regulation capability but also higher torque than the conventional HESF machine. Moreover, the influences of the key design parameters on the hybridization ratio in the PS-HESF machines are investigated. A prototype machine is manufactured and tested to validate the predictions. [ABSTRACT FROM PUBLISHER]

Partitioned stator (PS) machines employ two separated stators to accommodate armature windings and permanent magnets (PMs), respectively, alleviating the space conflict in stator-PM machines, and hence boosting the torque density. However, the PM usage volume in PS machines is relatively large, and thus the material cost is high, which is undesirable for the cost-sensitive applications. In this paper, a PS machine employing ferrite PM is presented, which takes advantage of larger available space for PMs while balances the performance and cost. The electromagnetic characteristics of an optimized ferrite PS machine and an NdFeB PS machine are evaluated together with a classic Prius2010 interior PM (IPM) machine as a baseline. Meanwhile, the economic issues are considered. The results reveal that the NdFeB PS machine has higher torque density than the Prius2010 IPM machine, but is more expensive, while the ferrite PS machine can significantly reduce the cost and still exhibit good performance. The demagnetization behavior of the ferrite PS machine is evaluated and a new method to improve the demagnetization withstand capability is proposed. Moreover, the mechanical analysis is conducted for the cupped rotor of PS machines. Finally, a pair of small-scaled prototypes are manufactured to validate the predictions. [ABSTRACT FROM PUBLISHER]

TiO 2 microflowers assembled by nanosheets are prepared by a one-step solvothermal process. The anatase-TiO 2 (B) dual-phase coexistence or anatase single phase is obtained under different annealing temperatures. Pt nanoparticles supported on the anatase-TiO 2 (B) microflowers are first applied to alcohol electrooxidation. The electrocatalytic performances of Pt/anatase-TiO 2 (B), Pt/anatase and Pt/carbon-black (Pt/C) on graphite substrates are systematically investigated. The Pt/anatase-TiO 2 (B) catalyst exhibits superior electrocatalytic activity and stability compared with that of Pt/anatase and Pt/C catalysts for methanol and ethanol in acidic and alkaline media, which is attributed to the large specific surface area, the porous channels to reduce the liquid sealing effect, the enhanced electronic conductivity by dual-phase coexistence and quick electron transfer from anatase phase to TiO 2 (B). [ABSTRACT FROM AUTHOR]

Helentrons represent a novel subtype of Helitrons. However, the evolutionary history of Helentrons in organisms is not clearly understood. In this study, we performed structure and autonomous partner analyses, which revealed that bm_455, a TE obtained from the Bombyx mori TE database, BmTEdb, was a member of Helentrons but not a long-terminal repeat (LTR) retrotransposon. Further analyses showed that bm_455 was also present in a wide range of insects including lepidopterans, coleopterans and hymenopterans using a homology-based search strategy. Several lines of evidence (high sequence identity, discontinuous distribution and lack of intense purifying selection) suggested that these elements could have been transferred into these species in part by horizontal transfers (HTs). Because Helentrons can capture host gene fragments, HTs of Helentrons might have a huge impact on their host genome evolution. [ABSTRACT FROM AUTHOR]

This paper presents a method for automatically constructing irregular floor plans. Given image patterns, the program produces a variety of layouts that satisfy users' geometric and topological requirements. The program extracts irregular regions from images via statistical region merging. It employs subgraph matching and simulated annealing to construct topologically feasible layouts. Methods for measuring similarities between the desired templates and irregular rooms are also reported. Applications using raster images and vector graphics are tested. Both applications generate feasible floor plans whose appearances resemble the input patterns. The results indicate that layout automation is valid without an orthogonal framework in the plane. Irregular layout synthesis allows architects to instantly implement visual preferences in early design stages. [ABSTRACT FROM AUTHOR]

Previously, we demonstrated that the soluble IL-6R (sIL-6R) plays an important role in the host antiviral response through induction of type I IFN and sIL-6R-mediated antiviral action via the IL-27 subunit p28; however, the mechanism that underlies sIL-6R and p28 antiviral action and whether type III IFN is involved remain unknown. In this study, we constructed a sIL-6R and p28 fusion protein (sIL-6R/p28 FP) and demonstrated that the fusion protein has stronger antiviral activity than sIL-6R alone. Consequently, knockout of sIL-6R inhibited virus-triggered IFN-λ1 expression. In addition, sIL-6R/p28 FP associated with mitochondrial antiviral signaling protein and TNFR-associated factor 6, the retinoic acid-inducible gene I adapter complex, and the antiviral activity mediated by sIL-6R/p28 FP was dependent on mitochondrial antiviral signaling protein. Furthermore, significantly reduced binding of p50/p65 and IFN regulatory factor 3 to the IFN-λ1 promoter was observed in sIL-6R knockout cells compared with the control cells. Interestingly, a novel heterodimer of c-Fos and activating transcription factor 1 was identified as a crucial transcriptional activator of IFN-λ1. The sIL-6R/p28 FP upregulated IFN-λ1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 to the IFN-λ1 promoter via the p38 MAPK signaling pathway. In conclusion, these results demonstrate the important role of sIL-6R/p28 FP in mediating virus-induced type III IFN production. [ABSTRACT FROM AUTHOR]

We report a Danio rerio transposon named DrTRT, for D. rerio Transposon Related to Tc1. The complete sequence of the DrTRT transposon is 1,563 base pairs (bp) in length, and its transposase putatively encodes a 338-amino acid protein that harbors a DD37E motif in its catalytic domain. We present evidence based on searches of publicly available genomes that TRT elements commonly occur in vertebrates and protozoa. Phylogenetic and functional domain comparisons confirm that TRT constitutes a new subfamily within the Tc1 family. Hallmark features of having no premature termination codons within the transposase, the presence of all expected functional domains, and its occurrence in the bony fish transcriptome suggest that TRTmight have current or recent activity in these species. Further analysis showed that the activity of TRT elements in these species might have arisen about between 4 and 19 Ma. Interestingly, our results also implied that the widespread distribution of TRT among fishes, frog, and snakes is the result of multiple independent HT events, probably from bony fishes to snakes or frog. Finally, the mechanisms underlying horizontal transfer of TRT elements are discussed. [ABSTRACT FROM AUTHOR]

Hybrid excited (HE) machines combine the advantages of both high torque density and excellent flux regulation capability, while also having extensive applications. A novel partitioned stator HE machine employing two stators to allocate armature windings and excitations separately, is proposed in this paper. The permanent magnet (PM) pole-pair and wound field pole-pair are alternately placed on one stator to exhibit parallel magnetic paths, while the armature windings are located on the other stator. The iron-piece-rotor is sandwiched between the two stators. This machine inherits the advantages of stator-PM machine and further benefits from attractive flux regulation capability due to parallel topology. The operating principle and the slot/pole combination rule that are different from the conventional PM machine are illustrated. The two-dimensional finite element technique is used to evaluate the electromagnetic performance, confirming the mentioned advantages. A prototype is manufactured and tested to validate the predictions. [ABSTRACT FROM PUBLISHER]

The aim of the present study was to investigate the overall clinical expression characteristics of the cluster of differentiation (CD)28 family receptors [CD28, inducible T-cell co-stimulator, programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 and B- and T-lymphocyte attenuator] on T cells in patients with chronic hepatitis B (CHB), analyze the correlations among these receptors and the clinical parameters, and to investigate the effects of PD-1 blockade on the receptor expression profiles, T-cell function and other biological effects. The expression characteristics of the CD28 family of receptors, the effects of PD-1 blockade on the receptor expression profiles and the levels of interferon (IFN)-γ were investigated in the T cells of patients with CHB. In addition, the transcription factor, T-box 21 (T-bet) and GATA binding protein 3 (GATA-3) mRNA expression levels were investigated in the peripheral blood mononuclear cells (PBMCs) of patients with CHB. The expression levels of the CD28 family receptors in the T cells of patients with CHB demonstrated distinct characteristics, for example levels of PD-1 and CTLA-4 on CD4 T cells and ICOS, PD-1, and BTLA on CD8 T cells were increased in cells from patients with CHB compared with those from the healthy individuals. A significant positive correlation was demonstrated among the serum HBV DNA titers and the levels of PD-1 on CD8+ T cells with the highest expression of PD-1 corresponding to viral levels >106 IU/ml. A significant positive correlation was observed between the serum HBV DNA titers and the expression levels of BTLA on CD8+ T cells with the highest expression of BTLA corresponding to viral levels >106 IU/ml. PD-1 blockade altered the expression profiles of CD28 family receptors in the T cells of patients with CHB, partly enhanced T cell function and increased the ratio of T-bet/GATA-3 mRNA in PBMCs. Thus, CD28 family receptors are potential clinical indicators for the rapid monitoring of changes in T cell function during CHB treatment. Furthermore, PD-1 blockade has a therapeutic potential that may be enhanced by modulating the expression of co-stimulatory and -inhibitory receptors of the CD28 family. [ABSTRACT FROM AUTHOR]

A partitioned stator hybrid excited machine is proposed, in which the permanent magnets and field windings are alternately placed on an inner stator separated from the outer stator having armature windings. This machine inherits the features of brushless machines and benefits from better space utilization. The operating principle and the effects of slot/pole combinations are investigated in detail. Further, based on 2-D finite-element analysis, the electromagnetic performances of the proposed machines, including back-electromotive force, cogging torque, flux regulation range, torque capability, power factor and torque–speed curve, are evaluated. The results reveal that the proposed machines can exhibit wide flux regulation range as well as good torque density. The prototype is manufactured and tested to validate the predictions. [ABSTRACT FROM PUBLISHER]

The discovery of the robust antidepressant actions of ketamine is regarded as one of the greatest advancements in depression treatment in the past 60 years. Recent findings have provided strong evidence for the presence of bidirectional communication networks between the gastrointestinal tract and the brain in depression. Moreover, increasing evidence supports the antidepressant role of ketamine in regulating the gut microbiome and microbiota-derived molecules; however, the mechanisms underpinning such effects are still ambiguous. This review summarizes the current understanding of the anti-depressant mechanisms of ketamine and its metabolites regarding the bidirectional regulation by microbiota–gut–brain axis. We review the relationship between gut microbiota and the antidepressant mechanisms of ketamine, and discuss the role of stress response, brain-derived neurotrophic factor (BDNF)-mediated neurogenesis, anti-inflammatory effect and neurotransmitters. • Ketamine and its metabolites exert rapid-acting and sustained antidepressant effects. • Gut microbiota contributes to the pathogenesis of depression and the antidepressant actions of ketamine and its metabolites. • The relationship between gut microbiota and the antidepressant effects of ketamine and its metabolites is related to stress response, BDNF expression, neurogenesis, anti-inflammatory effect and neurotransmitters. [ABSTRACT FROM AUTHOR]

A dual-stator hybrid-excited switched-flux (DS-HESF) machine, which is based on the conventional SF permanent magnet machine but employs a secondary stator to accommodate the field windings, is proposed in this paper. The DS-HESF machine inherits the robust rotor and benefits from a better space utilization. The topology and operating principle of the proposed machine are introduced in detail. Based on the 2-D finite-element analysis, the comparison between the DS-HESF machines having different rotor pole numbers is carried out, accompanied with a conventional HESF machine as a baseline. The results reveal that the DS-HESF machines exhibit not only higher torque density but also a better flux regulation capability. The prototype is manufactured and tested to validate the predictions. [ABSTRACT FROM PUBLISHER]

Intrinsic half-metallicity recently reported in zigzag edged SiC nanoribbons is basically undetectable due to negligible energy difference between the antiferromagnetic (AFM) and ferromagnetic (FM) configurations. In this Letter, by density functional theory calculations, we demonstrate a scheme of N doping at the carbon edge to selectively close the edge state channel at this edge and achieve 100% spin filtering, no matter whether it is in an AFM state or FM state. This turns SiC nanoribbon into a promising material for obtaining stable and completely spin polarized transport and may find application in spintronic devices. [ABSTRACT FROM AUTHOR]

BACKGROUND: Previous epidemiologic studies suggest associations between preterm birth and ambient air pollution. OBJECTIVE: We investigated associations between 11 ambient air pollutants, estimated by combining Community Multiscale Air Quality model (CMAQ) simulations with measurements from stationary monitors, and risk of preterm birth (< 37 weeks of gestation) in the U.S. state of Georgia. METHODS: Birth records for singleton births ≥ 27 weeks of gestation with complete covariate information and estimated dates of conception between 1 January 2002 and 28 February 2006 were obtained from the Office of Health Indicators for Planning, Georgia Department of Public Health (n = 511,658 births). Daily pollutant concentrations at 12-km resolution were estimated for 11 ambient air pollutants. We used logistic regression with county-level fixed effects to estimate associations between preterm birth and average pollutant concentrations during the first and second trimester. Discrete-time survival models were used to estimate third-trimester and total pregnancy associations. Effect modification was investigated by maternal education, race, census tract poverty level, and county-level urbanicity. RESULTS: Trimester-specific and total pregnancy associations (p < 0.05) were observed for several pollutants. All the traffic-related pollutants (carbon monoxide, nitrogen dioxide, PM2.5 elemental carbon) were associated with preterm birth [e.g., odds ratios for interquartile range increases in carbon monoxide during the first, second, and third trimesters and total pregnancy were 1.005 (95% CI: 1.001, 1.009), 1.007 (95% CI: 1.002, 1.011), 1.010 (95% CI: 1.006, 1.014), and 1.011 (95% CI: 1.006, 1.017)]. Associations tended to be higher for mothers with low educational attainment and African American mothers. CONCLUSION: Several ambient air pollutants were associated with preterm birth; associations were observed in all exposure windows. [ABSTRACT FROM AUTHOR]

We turn the Self-organizing Map (SOM) into an Oriented and Scalable Map (OS-Map) by generalizing the neighborhood function and the winner selection. The homogeneous Gaussian neighborhood function is replaced with the matrix exponential. Thus we can specify the orientation either in the map space or in the data space. Moreover, we associate the map’s global scale with the locality of winner selection. Our model is suited for a number of graphical applications such as texture/image synthesis, surface parameterization, and solid texture synthesis. OS-Map is more generic and versatile than the task-specific algorithms for these applications. Our work reveals the overlooked strength of SOMs in processing images and geometries. [ABSTRACT FROM AUTHOR]

BACKGROUND: Associations between pediatric emergency department (ED) visits and ambient concentrations of particulate matter ≤ 2.5 μm in diameter (PM2.5) have been reported in previous studies, although few were performed in nonmetropolitan areas. OBJECTIVE: We estimated associations between daily PM2.5 concentrations, using a two-stage model that included land use parameters and satellite aerosol optical depth measurements at 1-km resolution, and ED visits for six pediatric conditions in the U.S. state of Georgia by urbanicity classification. METHODS: We obtained pediatric ED visits geocoded to residential ZIP codes for visits with nonmissing PM2.5 estimates and admission dates during 1 January 2002-30 June 2010 for 2- to 18-year-olds for asthma or wheeze (n = 189,816), and for 0- to 18-year-olds for bronchitis (n = 76,243), chronic sinusitis (n = 15,745), otitis media (n = 237,833), pneumonia (n = 52,946), and upper respiratory infections (n = 414,556). Daily ZIP code-level estimates of 24-hr average PM2.5 were calculated by averaging concentrations within ZIP code boundaries. We used time-stratified case-crossover models stratified on ZIP code, year, and month to estimate odds ratios (ORs) between ED visits and same-day and previous-day PM2.5 concentrations at the ZIP code level, and we investigated effect modification by county-level urbanicity. RESULTS: A 10-μg/m³ increase in same-day PM2.5 concentrations was associated with ED visits for asthma or wheeze (OR = 1.013; 95% CI: 1.003, 1.023) and upper respiratory infections (OR = 1.015; 95% CI: 1.008, 1.022); associations with previous-day PM2.5 concentrations were lower. Differences in the association estimates across levels of urbanicity were not statistically significant. CONCLUSION: Pediatric ED visits for asthma or wheeze and for upper respiratory infections were associated with PM2.5 concentrations in Georgia. [ABSTRACT FROM AUTHOR]

The half-teeth-wound switched reluctance machines (HT-SRMs) having single-layer concentrated windings, feature simpler structures since the coil number is half, and phase-to-phase insulations in slot are eliminated. To evaluate the effects of winding configurations, the electromagnetic performances of HT-SRMs and conventional full-teeth-wound SRMs (FT-SRMs), including air-gap flux density, coil and phase flux linkage, inductance, torque, volt–ampere, and radial magnetic force (RMF), are comprehensively compared. The results based on theoretical analysis and finite-element (FE) method reveal that HT-SRMs would exhibit higher torque per ampere when the magnetic saturations are not too severe, whereas require higher voltage supply and generate more significant RMF. Further, it is found that the fault-tolerant capabilities of HT-SRMs are superior to FT-SRMs. A pair of prototypes with identical laminations but different winding configurations are manufactured and the experimental results confirm the predictions. [ABSTRACT FROM PUBLISHER]

The partitioned stator (PS) machine adopts two stators to allocate windings and permanent magnets (PMs) separately, increasing the space for PMs as well as armature coils to boost the electromagnetic torque and improving the thermal condition of PMs. In this paper, the PS switched-flux PM (PS-SFPM) machine and the PS flux reversal PM (PS-FRPM) machine are proved to inherently share the same operating principle and similar machine topology but with interior PM (IPM) and surface-mounted PM stators, respectively. Furthermore, four globally optimized PS machines with different inner stator topologies are compared in terms of back EMF, cogging torque, electromagnetic torque, torque per PM volume, and flux-weakening capability. The results reveal that the spoke-shaped IPM (IPM-spoke) inner stator exhibits the highest back EMF and hence the highest average torque, while the I-shaped IPM (IPM-I) stator has the best flux-weakening capability, and the V-shaped IPM (IPM-V) produces the highest torque per PM volume. Furthermore, four machines are redesigned with the same PM usage volume, and the results show that the PS-SFPM machine still exhibits the highest back EMF as well as torque although with sacrificed advantages. The finite-element analyses and experiments are used to confirm the predictions. [ABSTRACT FROM AUTHOR]

Bi 2 WO 6 hierarchical microspheres assembled by nanosheets and dispersed nanosheets were synthesized by hydrothermal reaction in different conditions. Ag 2 O nanoparticles were deposited on the surface of Bi 2 WO 6 microspheres and nanosheets by the chemical precipitation method. The photocatalytic performance of pure Bi 2 WO 6 nanostructures and Ag 2 O/Bi 2 WO 6 heterostructures were evaluated by the photocatalytic decolorization of RhB solution under visible-light irradiation. Compared with the pure Bi 2 WO 6 nanostructures, the Ag 2 O/Bi 2 WO 6 heterostructures exhibited an obviously enhanced photocatalytic activity. And photocatalytic activity of the Ag 2 O/Bi 2 WO 6 microspheres is higher than that of the Ag 2 O/Bi 2 WO 6 nanosheets. This work demonstrates that the Bi 2 WO 6 hierarchical three-dimensional structure is an excellent architecture for the loading of Ag 2 O nanoparticles to build a highly efficient photocatalyst. [ABSTRACT FROM AUTHOR]

Background Horizontal transfer (HT) of transposable elements (TEs) into a new genome is considered as an important force to drive genome variation and biological innovation. However, most of the HT of DNA transposons previously described occurred between closely related species or insects. Results In this study, we carried out a detailed analysis of four DNA transposons, which were found in the first sequenced twisted-wing parasite, Mengenilla moldrzyki. Through the homologybased strategy, these transposons were also identified in other insects, freshwater planarian, hydrozoans, and bats. The phylogenetic distribution of these transposons was discontinuous, and they showed extremely high sequence identities (>87%) over their entire length in spite of their hosts diverging more than 300 million years ago (Mya). Additionally, phylogenies and comparisons of transposons versus orthologous gene identities demonstrated that these transposons have transferred into their hosts by independent HTs. Conclusions Here, we provided the first documented example of HT of CACTA transposons, which have been so far extensively studied in plants. Our results demonstrated that bats had continuously acquired new DNA elements via HT. This implies that predation on a large quantity of insects might increase bat exposure to HT. In addition, parasite-host interaction might facilitate exchanging of their genetic materials [ABSTRACT FROM AUTHOR]

This paper presents a case-based design (CBD) focusing on the segmentation of building models and the synthesis of new compositions. Our TRAMMA (Topology Recognition and Aggregation of Mesh Models of Architecture) program is developed as an application of the method. The segmentation includes the recognition of floors, stairs, and walls out of the mesh models. The aggregation process recombines the building segments according to the user-defined topology. The topology representation of multi-story buildings and the spatial synthesis of 3D building models are integrated in the program. [ABSTRACT FROM AUTHOR]

Switched reluctance machines (SRMs) have been comprehensively researched, and they play an important role in the modern industrial field. The topology of SRMs is quite simple and only one set of windings is employed. Consequently, the winding configuration has an essential impact on performance. In this paper, a new winding configuration for SRMs with only half-teeth wound (HT-SRM) is proposed, which is totally different from the conventional SRMs with full-teeth wound (FT-SRM). First, the basic topology and operating principle of HT-SRMs are presented by a three-phase 12/8 prototype. Then, based on the 2-D finite element analysis, an optimization of the original 12/8 HT-SRM is conducted and a series of static characteristics of three SRMs, namely, a conventional 12/8 FT-SRM, an original 12/8 HT-SRM with the same iron laminations, and an optimal HT-SRM with the optimized dimensions, are compared. Finally, three 12/8 SRM prototypes are fabricated and the experimental results verify the theoretical analysis and the corresponding finite element analysis-based predictions. [ABSTRACT FROM AUTHOR]

Horizontal transfer (HT) of a transposable element (TE) into a new genome is regarded as an important force to drive genome variation and biological innovation. In addition, HT also plays an important role in the persistence of TEs in eukaryotic genomes. Here, we provide the first documented example for the repeated HT of three families of Chapaev transposons in a wide range of animal species, including mammals, reptiles, jawed fishes, lampreys, insects, and in an insect bracovirus. Multiple alignments of the Chapaev transposons identified in these species revealed extremely high levels of nucleotide sequence identity (79–99%), which are inconsistent with vertical evolution given the deep divergence time separating these host species. Rather, the discontinuous distribution amongst species and lack of purifying selection acting on these transposons strongly suggest that they were independently and horizontally transferred into these species lineages. The detection of Chapaev transposons in an insect bracovirus indicated that these viruses might act as a possible vector for the horizontal spread of Chapaev transposons. One of the Chapaev families was also shared by lampreys and some of their common hosts (such as sturgeon and paddlefish), which suggested that parasite–host interaction might facilitate HTs. [ABSTRACT FROM AUTHOR]

A new analytical method for determining deoxycytidine kinase (dCK) activity in biological milieus using luminescence is reported here. This method, based on utilizing adenosine triphosphate (ATP) as the sole phosphate donor in the kinase reaction and monitoring ATP consumption via a luciferase-based chemiluminescence reaction, is capable of detecting dCK activity without the use of specific substrates or radioisotope techniques. Comparing with the reverse-phase high-performance liquid chromatography method, this new method is suggested to be efficient and sensitive. Further, application of the proposed method for profiling dCK activity in cultured cancer cells revealed that a cervix cell line exhibited the highest dCK activity to gemcitabine metabolism. [ABSTRACT FROM AUTHOR]

The switched reluctance machine (SRM) has attracted increasing attentions in recent years due to its inherent simplicity, robustness, reliability and high starting torque. Meanwhile, with the aggravation of the energy dilemma and environment contamination, the research on electric vehicles is becoming the focus in a large number of counties. In China, the study on electric bicycle, which possesses high performance-price ratio and suits characteristic conditions, absolutely contains remarkable values. Here, an in-wheel three-phase 12/16 SRM-based drive system is investigated for electric bicycle. Firstly, the structure of the SRM is discussed and the prototype is designed based on finite element analysis. Then, the detailed design process of SRM is described. Also, the influence of winding configuration on the electromagnetic performance is discussed. Finally, a 350 W prototype is manufactured and the experimental test is conducted based on an ARM-based controller. The measured results verify the performance of the SRM. [ABSTRACT FROM AUTHOR]

It has been always attractive to design a sustainable bio-derived adsorbent based on industrial waste lignin for removing organic dyes from water. However, existing adsorbent strategies often lead to the difficulties in adsorbent separation and recycling. Herein, we report a novel magnetically recyclable bio-adsorbent of Mg(OH) 2 /Fe 3 O 4 /PEI functionalized enzymatic lignin (EL) composite (EL-PEI@Fe 3 O 4 -Mg) for removing Congo red (CR) by Mannish reaction and hydrolysis-precipitation. The Mg(OH) 2 and PEI functionalized EL on the surface act as active sites for the removal of CR, while the Fe 3 O 4 allows for the easy separation under the help of a magnet. As-obtained EL-PEI@Fe 3 O 4 -Mg forms flower-like spheres and has a relatively lager surface area of 24.8 m2 g−1 which is 6 times that of EL. The EL-PEI@Fe 3 O 4 -Mg exhibits a relatively high CR adsorption capacity of 74.7 mg g−1 which is 15 times that of EL when initial concentration is around 100 mg L−1. And it can be easily separated from water by applying an external magnetic field. Moreover, EL-PEI@Fe 3 O 4 -Mg shows an excellent anti-interference capability according to the results of pH values and salt ions influences. Importantly, EL-PEI@Fe 3 O 4 -Mg possesses a good reusability and a removal efficiency of 92 % for CR remains after five consecutive cycles. It is illustrated that electrostatic attraction, π-π interaction and hydrogen binding are primary mechanisms for the removal of CR onto EL-PEI@Fe 3 O 4 -Mg. This work provides a novel sustainable strategy for the development of highly efficient, easy separable, recyclability bio-derived adsorbents for removing organic dyes, boosting the efficient utilization of industrial waste lignin. A novel lignin-based bio-adsorbent with easy separability, recyclability, excellent anti-interference, and regeneration capabilities for efficient removal of Congo red was successfully prepared. [Display omitted] [ABSTRACT FROM AUTHOR]

Miniature inverted-repeat transposable elements (MITEs) are a specific group of nonautonomous DNA transposons, and they are distributed in a wide range of hosts. However, the origin and evolutionary history of MITEs in eukaryotic genomes remain unclear. In this study, six MITEs were identified in the silkworm (Bombyx mori). Five elements are grouped into four known superfamilies of DNA transposons, and one represents a novel class of MITEs. Unexpectedly, six similar MITEs are also present in the triatomine bug (Rhodnius prolixus) that diverged from the common ancestor with the silkworm about 370 Ma. However, they show different lengths in two species, suggesting that they are different derivatives of progenitor transposons. Three direct progenitor transposons (Sola1, hobo/Ac/Tam [hAT], and Ginger2) are also identified in some other organisms, and several lines of evidence suggested that these autonomous elements might have been independently and horizontally transferred into their hosts. Furthermore, it is speculated that the twisted-wing parasites may be the candidate vectors for these horizontal transfers. The data presented in this study provide some new insights into the origin and evolutionary history of MITEs in the silkworm and triatomine bug. [ABSTRACT FROM AUTHOR]

Highlights: [•] Submicrometer-sized TiO2 spheres are employed to obtain highly efficient Pt/TiO2 electrocatalyst. [•] This electrocatalyst used for alcohol oxidation exhibits quite outstanding property. [•] The enhanced catalytic activity of the Pt/TiO2 spheres is owing to the mesoporous active sites and synergistic effect of Pt and TiO2. [Copyright &y& Elsevier]

The silkworm, Bombyx mori, is one of the major insect model organisms, and its draft and fine genome sequences became available in 2004 and 2008, respectively. Transposable elements (TEs) constitute ~40% of the silkworm genome. To better understand the roles of TEs in organization, structure and evolution of the silkworm genome, we used a combination of de novo, structure-based and homology-based approaches for identification of the silkworm TEs and identified 1308 silkworm TE families. These TE families and their classification information were organized into a comprehensive and easy-to-use web-based database, BmTEdb. Users are entitled to browse, search and download the sequences in the database. Sequence analyses such as BLAST, HMMER and EMBOSS GetORF were also provided in BmTEdb. This database will facilitate studies for the silkworm genomics, the TE functions in the silkworm and the comparative analysis of the insect TEs. [ABSTRACT FROM AUTHOR]

Spin crossover by means of an electric bias is investigated by spin-polarized density-functional theory calculations combined with the Keldysh nonequilibrium Green's technique in a molecular junction, where an individual single-molecule magnet Fe2(acpybutO)(O2CMe)(NCS)2 is sandwiched between two infinite Au(100) nanoelectrodes. Our study demonstrates that the spin crossover, based on the Stark effect, is achieved in this molecular junction under an electric bias but not in the isolated molecule under external electric fields. The main reason is that the polarizability of the molecular junction has an opposite sign to that of the isolated molecule, and thus from the Stark effect the condition for the spin crossover in the molecular junction is contrary to that in the isolated molecule. [ABSTRACT FROM AUTHOR]