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3 results on '"Huening, Tracy T."'

1. A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies

Author

Cheng, Yuan, primary, Rano, Thomas A, additional, Huening, Tracy T, additional, Zhang, Fengqi, additional, Lu, Zhijian, additional, Schleif, William A, additional, Gabryelski, Lori, additional, Olsen, David B, additional, Stahlhut, Mark, additional, Kuo, Lawrence C, additional, Lin, Jiunn H, additional, Xu, Xin, additional, Jin, Lixia, additional, Olah, Timothy V, additional, McLoughlin, Debra A, additional, King, Rick C, additional, Chapman, Kevin T, additional, and Tata, James R, additional

Published
2002
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2. Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library

Author

Rano, Thomas A, primary, Cheng, Yuan, additional, Huening, Tracy T, additional, Zhang, Fengqi, additional, Schleif, William A, additional, Gabryelski, Lori, additional, Olsen, David B, additional, Kuo, Lawrence C, additional, Lin, Jiunn H, additional, Xu, Xin, additional, Olah, Timothy V, additional, McLoughlin, Debra A, additional, King, Richard, additional, Chapman, Kevin T, additional, and Tata, James R, additional

Published
2000
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3. <atl>A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies

Author

Cheng, Yuan, Rano, Thomas A., Huening, Tracy T., Zhang, Fengqi, Lu, Zhijian, Schleif, William A., Gabryelski, Lori, Olsen, David B., Stahlhut, Mark, Kuo, Lawrence C., Lin, Jiunn H., Xu, Xin, Jin, Lixia, Olah, Timothy V., McLoughlin, Debra A., King, Rick C., Chapman, Kevin T., and Tata, James R.

Subjects
*PROTEOLYTIC enzymes, *GENE libraries, *PHARMACOKINETICS
Abstract

A combinatorial library of 300HIV protease inhibitors has been synthesized. The library was screened against recombinant wild-type and mutant HIV-1 protease enzymes. The pharmacokinetics of the library was evaluated by dosing in dogs. Compounds that are notably more potent than indinavir and have favorable pharmacokinetic properties were identified. [Copyright &y& Elsevier]

Published
2002
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