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7 results on '"Hugo Bertschy"'

1. The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Author

André Chaperon, Hugo Bertschy, Anne-Laurence Franz-Schrumpf, Bertrand Hugelet, Antonia Neels, Helen Stoeckli-Evans, and Reinhard Neier

Subjects
Biomimetic synthesis, Mukaiyama aldol reaction, Porphobilinogen, Silyl enol ether, Chemistry, QD1-999
Abstract

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

Published
2003
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2. Synthesis of Novel and Stable 5-Aminolevulinic Acid Derivatives for the Efficient Synthesis of 5-Aminolevulinic Acid Based Prodrugs

Author

Reinhard Neier, Hugo Bertschy, Yann Berger, Virginie Wenger, and Ramakrishnan Vallinayagam

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Chemical transformation, chemistry, Organic Chemistry, Organic chemistry, Prodrug, Protecting group, Porphyrin, Catalysis, Amino acid
Abstract

The efficient synthesis of two stable, easily handled precursors of 5-aminolevulinate is reported. These precursors are stable to the chemical transformation needed for the synthesis of bioconjugates and can be readily deprotected in good yields.

Published
2007

3. A methanol/dioxygen biofuel cell that uses NAD+-dependent dehydrogenases as catalysts: application of an electro-enzymatic method to regenerate nicotinamide adenine dinucleotide at low overpotentials

Author

G. Tayhas R. Palmore, Hugo Bertschy, George M. Whitesides, and Steven H. Bergens

Subjects
medicine.medical_specialty, Chemistry, General Chemical Engineering, Inorganic chemistry, Overpotential, Nicotinamide adenine dinucleotide, Combinatorial chemistry, Analytical Chemistry, Catalysis, chemistry.chemical_compound, Glycerol-3-phosphate dehydrogenase, Bioelectrochemistry, Diaphorase, Electrochemistry, medicine, NAD+ kinase, Methanol
Abstract

Diaphorase catalyzes efficiently the oxidation of NADH to NAD + by benzylviologen. This reaction was used to regenerate the NAD + required for the biocatalyzed oxidation of methanol to CO 2 using NAD + -dependent dehydrogenases. A methanol/dioxygen biofuel cell was assembled using these bioreactions in the anode compartment. The open-circuit voltage of the cell was 0.8 V, and the maximum power output of the cell was 0.67 mW/cm 2 of graphite at 0.49 V. These results reflect the low overpotential at which NADH is oxidized and demonstrate a new approach to lowering voltage losses in biofuel cells due to activation overpotentials.

Published
1998

4. The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Author

Anne-Laurence Franz-Schrumpf, Reinhard Neier, Hugo Bertschy, Bertrand Hugelet, Antonia Neels, Helen Stoeckli-Evans, and André R. Chaperon

Subjects
Silyl enol ether, Stereochemistry, Porphobilinogen, General Medicine, General Chemistry, Chemistry, chemistry.chemical_compound, Biomimetic synthesis, Aldol reaction, chemistry, Mukaiyama aldol reaction, QD1-999, Retrosynthetic analysis
Abstract

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

Published
2007

5. Eine neuartige Pyrrolsynthese

Author

Reinhard Neier, Hugo Bertschy, and Anne Meunier

Subjects
chemistry.chemical_compound, Biosynthesis, Chemistry, Stereochemistry, Regioselectivity, Aldol condensation, General Medicine, Pyrrole
Published
1990

6. ChemInform Abstract: A Novel Pyrrole Synthesis

Author

Hugo Bertschy, Anne Meunier, and Reinhard Neier

Subjects
chemistry.chemical_compound, chemistry, General Medicine, Combinatorial chemistry, Pyrrole derivatives, Pyrrole
Published
1990

7. A Novel Pyrrole Synthesis

Author

Reinhard Neier, Hugo Bertschy, and Anne Meunier

Subjects
chemistry.chemical_compound, Chemistry, General Medicine, General Chemistry, Combinatorial chemistry, Catalysis, Pyrrole
Published
1990

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