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A més, formà generacions de jurisconsults determinants en el dret català. Com a moralista aprofundeix la confessió i la penitència, i representa, també, la voluntat missionera del seu segle. Alguns elements clau mostren aquesta voluntat en la predicació: l’encàrrec de la Summa contra gentiles a Tomàs d’Aquino i la fundació de l’Ordre de la Mercè, juntament amb Pere Nolasc, i de les escoles de llengües orientals per als predicadors. Tanmateix, els autors de l’article defensen que l’únic model interpretatiu que engloba la seva complexa activitat és el que l’interpreta com a pensador cristià, en totes les seves facetes. No oblidem que la figura de Sant Ramon ha tingut, també, un model interpretatiu lligat a la santedat popular., Revista Catalana de Teologia, Vol. 47, Núm. 2 (2022)

El proyecto que se presenta consiste en una aplicación de gestión contable para uso corporativo que se gestiona a través de la web. Permite a una empresa llevar su contabilidad y la de sus delegaciones por separado desde la misma aplicación. Ésta podrá ser utilizada por todos aquellos usuarios de la empresa o externos a ella a los que se les haya concedido los oportunos permisos. El projecte que es presenta consisteix en una aplicació de gestió comptable per a ús corporatiu que es gestiona a través de la web. Permet a una empresa portar la seva comptabilitat i la de les seves delegacions per separat des de la mateixa aplicació. Aquesta podrà ser utilitzada per tots aquells usuaris de l'empresa o externs a ella als quals se'ls hagi concedit els oportuns permisos.

La finalitat del projecte és la realització d'una aplicació per gestionar l'activitat d'una cafeteria (Andana). El projecte consta de dues parts ben diferenciades: una part interna o Intranet, en la qual el propietari podrà portar un control del negoci i on podrà establir una interacció amb els clients, fet que ajudarà a millorar la gestió del negoci; i una part externa o web pública, accessible per a tothom. Per dur-lo a terme s'ha fet servir el gestor de continguts (CMS) Joomla. La finalidad del proyecto es la realización de una aplicación para gestionar la actividad de una cafetería (Andana). El proyecto consta de dos partes bien diferenciadas: una parte interna o Intranet, en la que el propietario podrá llevar un control del negocio y donde podrá establecer una interacción con los clientes, cosa que ayudara a mejorar la gestión del negocio, y una parte externa o web pública, accesible para todo el mundo. Para llevarlo a cabo se ha utilizado el gestor de contenidos (CMS) Joomla. The aim of this project is to create an application in order to manage the activity of a cafeteria (Andana). The project has two distinct parts: an internal part or Intranet, in which the owner can keep full track of business and where an interaction with customers it's possible, thus helping to improve business management, and an external part or public website, accessible to everyone. Joomla has been the CMS (Content Management System) of choice.

Aquest projecte consisteix en la informatització d'una empresa tradicional dedicada a la fabricació i venda de productes de pastisseria. El projecte es divideix en dos parts essencials: millora i dotació de la nova xarxa informàtica amb tots el serveis necessaris pels nous requeriments de creixement de l'empresa en l'obertura de nous punts de venda i la seva gestió, i proporcionar presència a Internet, a través d'una botiga on-line. Este proyecto consiste en la informatización de una empresa tradicional dedicada a la fabricación y venta de productos de pastelería. El proyecto se divide en dos partes esenciales: mejora y dotación de la nueva red informática con todos los servicios necesarios para los nuevos requerimientos de crecimiento de la empresa en la apertura de nuevos puntos de venta y su gestión, y proporcionar presencia en Internet, a través de una tienda on-line. This project involves the computerization of a traditional company engaged in the manufacture and sale of confectionery. The project is divided into two essential parts: improvement and provision of new computer network with all services needed by the new requirements of growing company opening new stores and their management, and providing internet presence through an online store.

Resumen A principios del siglo xixlos literatos de la capital de España estaban divididos en dos facciones: una progresista y otra conservadora. Estas posiciones ideológicas contaminaron la literatura. Los progresistas utilizaron como bandera un texto retórico del predicador escocés Hugo Blair (1718-1800); los conservadores, un texto del esteta francés Charles Batteux (1713-1780). El uso de Blair representó también una vía más de introducción del pensamiento liberal inglés y la divulgación de Edmund Burke, de especial interés para la oposición entre lo bello y lo sublime. Hasta ese momento, los conceptos de lo bello y lo sublime se entendían como conceptos encadenados. En Barcelona, la influencia de Blair se ve en la obra del fraile liberal Manuel Casamada (1772-1841) y en el discurso, inédito, que pronunció en la Real Academia de Buenas Letras de Barcelona (1837), que ha sido incluido, transcrito y anotado, en este artículo. Palabras clave: Hugo Blair, Manuel Casamada, bello, sublime, estética Abstract In early nineteenth century, the writers of the capital of Spain were divided into two factions: one conservative and one progressive. These ideological positions were transferred to literature. The progressives used as flag a rhetorical text of the Scottish preacher Hugh Blair (1718-1800), the conservatives, a text of the French esthete Charles Batteux (1713-1780). Blair’s use represents one route of introduction of liberal English thought and the popularization of Edmund Burke, work of particular interest to the opposition between the beautiful and the sublime. Until then, the concepts of beauty and the sublime understood as linked concepts. In Catalonia, Blair's influence is seen in the work of the Liberal priest Manuel Casamada (1772-1841) and in the speech, unedited, who spoke at the Real Acadèmia de Bones Lletres de Barcelona(1837), which has been included, transcribed and annotated, in this article. Key words: Hugh Blair, Manuel Casamada, beautiful, sublime, aesthetic

Resumen Introduccion La linfadenectomia en el cancer de prostata (CP) es el procedimiento mas fiable para la deteccion de metastasis linfaticas. La extension optima de la misma aun es un tema en debate. Objetivo Analizar el rendimiento diagnostico y las complicaciones de la linfadenectomia ampliada (LFDNA) y limitada (LFDNL) en una serie de pacientes con CP de alto riesgo sometidos a prostatectomia radical (PR). Material y metodos Estudio retrospectivo de pacientes con CP de alto riesgo de D’Amico sometidos a PR con linfadenectomia entre 1999- 2014. Analisis comparativo de la capacidad de diagnostico de metastasis linfaticas de la LFDNA y LFDNL y de las complicaciones postoperatorias a 90 dias. Resultados Se analizaron 93 pacientes, 20 (21,5%) sometidos a LFDNA y 73 (78,5%) a LFDNL. La edad media de la serie fue de 65,26 anos (DE 5,51). La mediana de seguimiento fue de 1,51 (0,61-2,29) anos en el grupo de LFDNA y 5,94 (3,61-9,10) en LFDNL. La mediana de ganglios obtenidos fue de 13 (9-23) en las LFNDA vs. 5 (2-8) en las limitadas (p El porcentaje global de complicaciones a 90 dias fue 35,5% (33 pacientes). Del grupo de LFDNA 12 pacientes (60%) presentaron complicaciones, frente a 21 (28,8%) en LFDNL (p = 0,016), sin encontrar diferencias significativas en la gravedad segun la escala de Clavien (p = 0,73). Conclusiones En nuestra serie, la deteccion de ganglios metastasicos ha sido significativamente superior en la LFDNA. La LFDNA aumenta el numero de complicaciones, sin encontrar diferencias con la LFDNL en la gravedad segun la escala de Clavien modificada.

Background Lymphadenectomy for prostate cancer (PC) is the most reliable procedure for detecting lymphatic metastases. The optimal extension of this procedure is still a topic of debate. Objective To analyze the diagnostic performance and complications of extended lymphadenectomy (ELD) and limited lymphadenectomy (LLD) in a series of patients with high-risk PC who underwent radical prostatectomy (RP). Material and methods A retrospective study was conducted on patients with high d’Amico risk who underwent RP with lymphadenectomy between 1999 and 2014. A comparative analysis was performed of the diagnostic capacity of lymphatic metastases of ELD and LLD and of postoperative complications at 90 days. Results Ninety-three patients were analyzed, 20 (21.5%) and 73 (78.5%) of whom underwent ELD and LLD, respectively. The mean age of the series was 65.26 years (SD, 5.51). The median follow-up was 1.51 (0.61–2.29) years in the ELD group and 5.94 (3.61–9.10) in the LLD group. The median number of nodes obtained was 13 (9–23) in the ELD group compared with 5 (2–8) in the LLD group (p

耶稣会士对中文孜孜不倦的研究，是他们 具有代表性的适应政策的核心要素。然而， 这种倾向并不只限于耶稣会士。其他修会从 一开始也表现出相同的倾向。虽然根据西班 牙帝国著名语言学家尼布里亚（Nebrija） 提倡的传教方针，应该用西班牙语来传播福 音，但前往美洲和亚洲的修士从一开始就致 力于学习当地语言。随着16世纪墨西哥词典 和语言的发展，西汉翻译文本已在菲律宾群 岛崭露头角，其中以高母羡（Juan Cobo）的 著作为代表。17世纪已经开始出现一些汉语 词汇、语法和语言教学的书籍，多明我会的 闵明我（Domingo Fernández de Navarrete） 也编写过一部相当简明的字典。同修会弗朗 西斯科•瓦罗的字典可谓是托钵修会研究中文 的顶峰。本文从17世纪的原始资料(手稿和印 刷品)入手，详细分析以方济各会和多明我会 为主的托钵修会的语言适应策略。 One of the essential elements of the muchadmired accommodation of the Jesuits was their dedication to the study of the Chinese language. However, this orientation is not exclusively to the Jesuits. The other religious orders also showed the same orientation from the first moment. Although following the imperial guidelines of Nebrija evangelization should be done in Spanish, the friars who left for America and Asia were focused from the first moment to learn the local languages. Following the line of sixteenthcentury Mexican dictionaries and languages, the translation of texts between Spanish and Chinese already had a clear representation in the Philippine Islands with the work of Juan Cobo. Throughout the XVII several vocabularies, grammars and language arts would appear while the work of the Dominican Domingo Fernández de Navarrete would include a very brief dictionary. This interest of mendicants by the local languages would culminate in the work of the Dominican Francisco Varo. Starting from the original sources —manuscripts and printed— of the seventeenth century, this communication will analyze in detail the linguistic accommodation of the mendicant orders with special emphasis on the Franciscans and the Dominicans.

La literatura sovint és reflex d’un entorn o de comportaments de persones representatives d’un lloc determinat. En aquesta exposició primer es tracta la figura de l’Estudiant de Vic, fent referència a altres figures de la tradició popular per tractar com neix el mite, l’apropiació que en fa la col·lectivitat i com s’expandeix a la literatura culta. Després es tracta de l’Esbart de Vic i la font del Desmai, tot mencionant altres grups i espais literaris, per plantejar les raons de la tria del lloc, l’ideari, el ritual i la pervivència en el temps. Finalment es tracta el cas de Vic com a ciutat literària, amb exemples d’altres ciutats europees.

The entry of the Manchus in the Chinese Empire introduced a new subject matter into the works about China that had been circulating in Europe until that time. In the second half of the XVII century, the Jesuits inundated the European scene with different publications centred on this historical event. In Spain, there were also texts that covered the changes in the Chinese dynasty right from the start. Specifically, information about the fall of the Ming dynasty basically came from three sources: the text by Bishop Juan de Palafox y Mendoza, Historia de la conquista de China por el Tártaro (1670, posthumous edition); the Hechos de la Orden de Predicadores en el Imperio de China (1667), by the Dominican Victorio Riccio, and the news collected by another Dominican, Fernández de Navarrete, in his Tratados históricos, políticos, éticos y religiosos de la monarquía de China (1676). The objective of this essay is to present these three authors and their works, analysing the information that they offer about the entry of the Manchus in China and the relation between them.

In a previous study, a new ceramic material (Bioeutectic ® ), prepared by slow solidification through the eutectic temperature-composition region of the wollastonite-tricalcium phosphate system, was found to be bioactive in static-simulated body fluid. The eutectic material reacts by dissolving the pseudowollastonite phase and forming a hydroxyapatite-like porous structure by a pseudomorphic transformation of the tricalcium phosphate lamellae, which in turn mimics porous bone. Later, a hydroxyapatite-like layer is formed by precipitation on the surface of the material. In the present study, the bioactivity of the Bioeutectic® material was assessed in dynamic simulated body fluid in order to improve the ingrowth of new bone into implants (osteointegration). Samples of the material were soaked for 2 weeks in a dynamic simulated body fluid (1 mL/min) at 37°C. The experiment showed that there is no precipitation of hydroxyapatite-like layer on the surface of a the material. Otherwise, a complete transformation of the eutectic material takes place, giving rise to a hydroxyapatite artificial porous bone. The dynamic model used in this study may be better than the usual static immersion model in imitating the physiological condition of bone-like apatite formation.

Lymphadenectomy for prostate cancer (PC) is the most reliable procedure for detecting lymphatic metastases. The optimal extension of this procedure is still a topic of debate.To analyse the diagnostic performance and complications of extended lymphadenectomy (ELD) and limited lymphadenectomy (LLD) in a series of patients with high-risk PC who underwent radical prostatectomy (RP).A retrospective study was conducted on patients with high d'Amico risk who underwent RP with lymphadenectomy between 1999 and 2014. A comparative analysis was performed of the diagnostic capacity of lymphatic metastases of ELD and LLD and of postoperative complications at 90 days.Ninety-three patients were analysed, 20 (21.5%) and 73 (78.5%) of whom underwent ELD and LLD, respectively. The mean age of the series was 65.26 years (SD, 5.51). The median follow-up was 1.51 (0.61-2.29) years in the ELD group and 5.94 (3.61-9.10) in the LLD group. The median number of nodes obtained was 13 (9-23) in the ELD group compared with 5 (2-8) in the LLD group (p.001). The percentages of patients with positive nodes in the ELD and LLD groups were 35% and 5.47%, respectively (p.001). The overall complication rate at 90 days was 35.5% (33 patients). In the ELD group, 12 patients (60%) had complications, compared with 21 patients (28.8%) in the LLD group (p=.016), with no significant differences in severity according to the Clavien scale (p=.73).In our series, the detection of metastatic nodes was significantly greater with ELD. ELD increases the number of complications, with no differences compared with LLD in severity according to the modified Clavien scale.

The work examines the influence of the microstructure on the in vitro bioactivity of two glass-ceramics with the same chemical composition in the SiO 2 –CaO system. Ceramizing a glass, via powder technology route (W1), and by sol–gel method (W2), formed two glass-ceramics composed of the same crystalline phases, but differed in microstructure. Both glass-ceramics were soaked in simulated body fluid up to 4 weeks using the same conditions. An hydroxyapatite (HA)-like layer formed on the surfaces of both samples but a different formation rates yielded differences in the microstructure. The W2 glass-ceramic showed faster HA-like formation because its smaller crystalline grains dissolved more readily. In addition, the thicker glassy phase at the grain boundaries facilitated a faster formation of silanol groups on the surface of the amorphous SiO 2 interlayer, a reaction that is considered to be a prerequisite for HA-like formation. Comparison of glass-ceramics synthesized by the two preparation methods was carried out. The interfacial reaction product was examined by scanning and transmission electron microscopy. Both instruments were fitted with energy-dispersive X-ray analyzers. Additional changes in ionic concentration, using inductively couple plasma atomic emission spectroscopy, were determined.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Cushioning is an important aspect in hydraulic cylinder performance. The piston has to be decelerated before it strikes the end cap in order to avoid stresses in the cylinder components and reduce vibration that can be transmitted to the machine. One of the least-studied methods is internal cushioning by grooves in the piston. In this method, the flow is throttled with adequately designed grooves when the piston reaches the outlet port position. The purpose of the present work is to present a method to estimate the pressure-drop coefficients for a certain design of piston grooves in order to provide a model to develop a dynamic system simulation of the cushion system. The method is based on a computational fluid dynamic simulation of flow through piston grooves to the outlet port for each piston’s static position. The results are compared with experimental measurements, and a correction, based on Reynolds number, is proposed. Good agreement, below 16%, was obtained for all the positions but particularly for the last grooves, for which the numerical result’s deviation to the experimental measurements was less than 10%. In general, the numerical simulation tended to underestimate the pressure drop for the first grooves and overestimate the calculation for the last grooves.

El presente artículo se inserta en el corazón mismo del debate contemporáneo sobre la constitución de la persona. El denominado personalismo dialógico o comunitario, liderado especialmente por E. Mounier, tiene "la convicción de que sólo en el diálogo amoroso, o en el amor dialógico del yo-tú, existen ambos como personas, alcanzan una existencia propiamente personal". Las filosofías de la persona, en cambio, en la línea neotomista de J. Maritain, y entre las que se encontraría la de K. Wojtyla, creen que la relación yo-tú, aunque muy importante, se sitúa no en la constitución original de la p e r s o n a , s i n o " p o s t e r i o rme n t e " , presuponiendo que la persona es anterior al hecho mismo de la relación yo-tú. Una distinción que parece sutil, pero que es decisiva para la comprensión del ser humano.

L’autor fa un repàs al conjunt de narracions recollides pel Grup de Recerca Folklòrica d’Osona al llarg de la seva història. Parla de la metodologia del treball d’investigació i del folklore com a realitat comunicativa i ressalta la importància de la conversa. Presenta els grans temes de recerca: «Encantades», «Condemnats», «El follet», «Bruixes», «Apareguts», «Poders», «Éssers del cel i de l’infern», «Natura», «De llocs», «Bandolers» i «Contes», i dóna una selecció de les narracions més interessants.

A 33-year-old woman sought medical attention for a painful swelling of the left ankle. Plain radiographs revealed an osteolytic lesion involving the left distal tibia. An excisional biopsy provided the diagnosis of leiomyosarcoma in the tibia. A staging work-up was performed and an abdominal CT showed 4 liver hypodense lesions in both lobes with peripheral contrast enhancement. A liver biopsy confirmed the diagnosis of epithelioid hemangioendothelioma of the liver. No association between these two entities has been described before. This case introduces the importance of the pathological confirmation of apparent metastatic lesions in low grade sarcomas and provides a review of the literature of both tumours.

El llobarro, és una de les espècies tradicionalment més apreciada en el Mediterrani, conjuntament amb l’orada. La seva alta valoració i la limitada oferta pesquera (actualment de 1.000 tones anuals), van fer que els preus del mercat fossin molt alts (19 €/kg) i com a conseqüència, va incrementar l’activitat aqüícola a partir de l’any 1985. Van haver de passar més de deu anys, perquè l’oferta aqüícola d’Espanya s’igualés amb la pesquera, l’any 1993. A partir d’aquest moment, la progressió va ser espectacular, passant de 370 tones a l’any 1993 a 4.513 l’any 2004. Aquest increment continuat de l’oferta ha modificat els preus, provocant una reducció d’aquests. La situació del sector durant el 2003-2004 va ser de recuperació, amb un relentiment de l’increment de la producció i un augment pausat dels preus, provocat per una supressió de les ajudes a la producció per part de la Unió Europea (Luna Sotorrío, L. et al, 2004).

El treball descriu el naixement d’un rumor que va fer posar en peus de guerra un estadi de futbol. El diumenge 21 de marc del 2004 s’enfrontaven l’equip de la Roma i del Lazio, els dos equips de la ciutat de Roma. Les dues aficions estan enfrontades. Tradicionalment son enemigues i per aixo era un partit d’alt risc. Hi havia uns 80.000 assistents i el partit es retransmetia per la RAI, la televisio italiana. La primera part va transcorrer amb la duresa propia d’un derbi. Durant la mitja part va correr la noticia que la policia havia mort un nen en els enfrontaments a fora del camp de futbol. Tant els seguidors de la Roma com del Lazio van unir-se i es van enfrontar contra la policia. De l’enfrontament entre tifosi i policia hi va haver 167 ferits (153 policies i 14 tifosi) i 18 detinguts. Dels 153 membres de l’ordre public ferits, 95 eren policies, 35 de l’arma dels carabinieri i 23 de la guardia de finances. Les perdues materials es van comptabilitzar en uns 200.000 euros.

Background Study results demonstrated that IFN augments BEV activity and improves median PFS in pts with mRCC. Thus, combination BEV + IFN is a standard first-line treatment option for mRCC. Combining BEV with the mTOR inhibitor EVE may be an efficacious and well-tolerated treatment option. The open-label, phase II RECORD-2 trial compared first-line EVE + BEV and IFN + BEV in mRCC. Patients and methods: Therapy-naive pts with clear cell mRCC and prior nephrectomy were randomized 1:1 to BEV 10 mg/kg IV every 2 weeks with either EVE 10 mg oral daily or IFN (9 MIU SC 3 times/week, if tolerated). Tumour assessments were every 12 weeks. Primary objective was treatment effect on progression-free survival (PFS) per central review based on an estimate of the chance of a subsequent phase III trial success (50% threshold for phase II success). Results In EVE + BEV (n = 182) and IFN + BEV (n = 183) arms, median age was 60/60 years, 76/72% of pts were men, MSKCC risk was favourable/intermediate/poor in 36/57/7% and 36/57/7% of pts, and 43/46% of pts had >2 organs involved, respectively. For EVE + BEV and IFN + BEV, median treatment duration was 8.5/8.3 months, respectively; 23/26% of pts discontinued due to AEs. In EVE + BEV and IFN + BEV arms, median PFS by central review was 9.3/10.0 months (HRIFN/EVE, 0.91; 95% CI, 0.69-1.19; P =0.485), respectively; probability of subsequent phase III success was 5.1%. Results of central and local PFS analysis were consistent. Objective response rate was 27/28% in EVE + BEV and IFN + BEV arms, respectively. Median overall survival (OS) was not reached in the EVE + BEV arm and was 25.9 months (95% CI: 21.1, 30.2) in the IFN + BEV arm. Most frequent AEs (%) were stomatitis (63), proteinuria (49), diarrhoea (39), hypertension (38), and epistaxis (35) in EVE + BEV arm and decreased appetite (45), fatigue (41), proteinuria (37), and pyrexia (35) in IFN + BEV arm. Conclusions In RECORD-2, PFS and tolerability were similar for first-line EVE + BEV and IFN + BEV. Final OS analysis will occur after 2-year follow-up. Disclosure A. Ravaud: Alain Ravaud is a member of global, European, and/or French boards on urological tumors for Pfizer, Novartis, GlaxoSmithKline, Bayer-Schering, and Dendreon, and has received institutional grant support from Pfizer, Novartis, and Roche. O. Anak: Ozlem Anak is an employee of Novartis Pharma AG. D. Pelov: Diana Pelov is an employee of Novartis Pharmaceuticals Corporation. A. Louveau: Anne-Laure Louveau is an employee of Novartis Pharma S.A.S. T. M-H: Tay M-H is a speaker for an advisory board for Novartis Pharmaceuticals Corporation. B. Melichar: Bohuslav Melichar has received honoraria from Novartis and Roche and served on an advisory board for Roche. All other authors have declared no conflicts of interest.

Introduction Sunitinib is a standard treatment for kidney cancer, however in some patients response is lacking. Molecular predictors of outcome could deeply impact patient care. Methods We conducted an observational, prospective study in 15 institutions members of the Spanish Oncology Genitourinary Group (SOGUG). Inclusion criteria were patients with confirmed advanced clear cell renal cell carcinoma with no prior treatment, planned to receive sunitinib according to local practice. From paraffin embedded tumor samples a Tissue MicroArray (TMA) was constructed and evaluated independently by two pathologists, also blinded to clinical data. Expression of Carbonic Anhydrase IX, P-glicoprotein, Vascular Endothelial Growth Factor (VEGF), VEGF-Receptor 1,2 and 3 (VEGFR1,2 and 3), Platelet-Derived Growth Factor Receptor (PDGFR-Beta), Hypoxia-Inducible Factor 2 alpha (HIF2α) and Von Hippel-Lindau protein (pVHL) was assessed. In addition the presence of VHL gene mutations was studied. Results 101 patients were recruited from 2007 to 2010. TMA was constructed from 69 tumor samples. In multivariable analysis, HIF2α (HR 0.17 (0.05-0.64) p = 0.0083) and PDGFRβ (HR 0.042 (0.003-0.70) p = 0.028) overexpression correlated with progressive disease (PD) as best response. A similar trend in PFS and OS was observed for HIF-alfa but did not reach statistical significance. Progression free survival (PFS) was longer in cases with high VEGFR3 expression (HR 0.42 (0.21-0.83) p = 0.013). Interestingly, low levels of this protein strongly correlated (r = -0.441 P = 0.0003) with the presence of a germline SNP (VEGFR3 rs307826) that has been previously identified as a sunitinib resistance predictor by our group. Finally overexpression of VEGF (HR 4.6 (1.5-13.6), p= 0.0063), and VEGFR1 (HR 6.2 (1.2-32.2) p = 0.031) were associated with poor overall survival (OS). VHL gene alterations could only be determined in 30 cases, with 20 (66%) presenting a pathological mutation. No association with outcome could be established. Conclusion Expression of some proteins involved in neoangiogenesis pathway could play a role in sunitinib sensitivity and resistance. A significant association between low expression of VEGFR3 and one SNP in such gene, both correlated with poor outcome, deserves further investigation. Disclosure All authors have declared no conflicts of interest.

This study has given evaluation of a new pneumallergen diagnostic test CIS Allergen Screen I in comparison with Pharmacia Cap System and intradermal skin test. Five allergens (Mite (DPT) D1, Mite (DF) D2, Cat E1, Dog E2, Orchard grass G3) have been studied with in vitro tests (CIS Allergen Screen I Cap System) and the results obtained gave on patient to patient comparison a sensitivity of 91%, a specificity of 100% and on allergen comparison a sensitivity of 84%, a specificity of 99% and an accuracy of 93%. Compared with intradermal skin test for two allergens (Mite (DT) D1 and Orchard grass G3), CIS Allergen Screen I have good results to G3 but less specificity and sensitivity to D1. These results could be to depend on different standardisation between allergen extracts especially for Mite.