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L‐Hexoses are rare but biologically significant components of various important biomolecules, however, most are prohibitively expensive if commercially available, limiting their study and biotechnological exploitation. New, efficient methods to access L‐hexoses and their derivatives are thus of great interest. In a previous study, we showcased a stereoselective Bu 3 SnH‐mediated transformation of a 5‐ C ‐bromo‐D‐glucuronide to an L‐iduronide. We have now drawn inspiration from this result to derive a new methodology which can be harnessed to access other L‐hexoses. DFT calculations demonstrate that a combination of a β‐F at the anomeric position and a methoxycarbonyl substituent at C‐5 is key to optimising the selectivity for the L‐hexose product. Our investigations have also culminated in the development of the shortest known synthetic route to a derivative of L‐idose from commercially available starting material (45% yield over 3 steps). Collectively, these results address the profound lack of understanding about how to synthesise L‐hexoses in a stereoselective fashion.

Iterative reconstruction can optimize radiation dose and improve image quality on CT scan. This research method is quantitative analytic with the analysis of the results of the head CT examination parameters associated with image quality to changes in variations of 80 kV, 100 kV, 120 kV with the use of iterative reconstruction. Image quality measurements are the Hounsfield Unit (HU) value, standard deviation, and Signal to Noise Ratio (SNR) using Radiant Viewers. Effective dose measurement using the Dose Length Product (DLP). Then perform the Kruskal Wallis test to find out whether there is an effect of tube voltage and Iterative Reconstruction on the SNR value using IBM SPSS version 24. The results image quality of the HU value increase due to changes in the kV value, but the value does not change significantly when the iDose changes, for the standard The deviation has decreased due to changes in kV, but the value of the value does not experience a significant change at the time of change in iDose, while SNR increases due to changes in kV value and changes in iDose. The percentage ratio of the effective dose in the use of standard kV with 80 kV decreased radiation dose by 62%, while at 100 kV there was a decrease of 25%, and the use of 120 kV experienced an increase of 25%. The results of the Kruskal Wallis test p-value

OBJECTIVES The aim of this study was to investigate the clinical feasibility of the simultaneous reduction of radiation and contrast doses using spectral computed tomography (CT) in patients at high-risk for hepatocellular carcinoma. MATERIALS AND METHODS Between May 2017 and March 2018, this prospective study recruited participants at risk of hepatocellular carcinoma with body mass indexes less than 30 and randomly assigned them to either the standard-dose group or the double low-dose group, which targeted 30% reductions in both radiation and contrast media (NCT03045445). Lesion conspicuity as a primary endpoint and lesion detection rates were then compared between hybrid iterative reconstruction (iDose) images of standard-dose group and low monoenergetic (50 keV) images of double low-dose group. Qualitative and quantitative image noise and contrast were also compared between the 2 groups. Participants and reviewers were blinded for scan protocols and reconstruction algorithms. Lesion conspicuity was analyzed using generalized estimating equation analysis. Lesion detection was evaluated using weighted jackknife alternative free-response receiver operating characteristic analysis. RESULTS Sixty-seven participants (male-to-female ratio, 59:8; mean age, 64 ± 9 years) were analyzed. Compared with the standard-dose group (n = 32), significantly lower CTDIvol (8.8 ± 1.7 mGy vs 6.1 ± 0.6 mGy) and contrast media (116.9 ± 15.7 mL vs 83.1 ± 9.9 mL) were utilized in the double low-dose group (n = 35; P < 0.001). Comparative analysis demonstrated that lesion conspicuity was significantly higher on 50 keV images of double low-dose group than on iDose images of standard dose on both arterial (2.62 [95% confidence interval (CI), 2.31-2.93] vs 2.02 [95% CI, 1.73-2.30], respectively, P = 0.004) and portal venous phases (2.39 [95% CI, 2.11-2.67] vs 1.88 [95% CI, 1.67-2.10], respectively, P = 0.005). No differences in lesion detection capability were observed between the 2 groups (figure of merit: 0.63 in standard-dose group; 0.65, double low-dose group; P = 0.52). Fifty kiloelectronvolt images of double low-dose group showed better subjective image noise and contrast than iDose image of standard-dose group on arterial and portal venous phases (P < 0.001 for all). Contrast-to-noise ratio of the aorta and portal vein was also higher in double low-dose group than in standard-dose group (P < 0.001 for all), whereas there was no significant difference of quantitative image noise between the 2 groups on arterial and portal phases (P = 0.4~0.5). CONCLUSIONS Low monoenergetic spectral CT images (50 keV) can provide better focal liver lesion conspicuity than hybrid iterative reconstruction image of standard-dose CT in nonobese patients while using lower radiation and contrast media doses.

Purpose Noise power spectrum (NPS) is a commonly used performance metric to evaluate noise-reduction techniques (NRT) in imaging systems. The images reconstructed with and without a NRT can be compared via their NPS to better understand the NRT's effects on image noise. However, when comparing NPSs, simple visual assessments or a comparison of NPS peaks or medians are often used. These assessments make it difficult to objectively evaluate the effect of noise reduction across all spatial frequencies. In this work we propose a new noise reduction profile (NRP) to facilitate a more complete and objective evaluation of NPSs for a range of NRTs used specifically in computed tomography (CT). Methods and materials The homogeneous section of the ACR or Catphan phantoms was scanned on different CT scanners equipped with the following NRTs: AIDR3D, AiCE, ASiR, ASiR-V, TrueFidelity, iDose, SAFIRE, and ADMIRE. The images were then reconstructed with all strengths of each NRT in reference to the baseline filtered back projection (FBP) images. One set of the baseline FBP images was also processed with PixelShine, an NRT based on artificial intelligence. The NPSs of the images before and after noise reduction were calculated in both the xy-plane and along the z-direction. The difference in the logarithmic scale between each NPS (baseline FBP and NRT) was then calculated and deemed the NRP. Furthermore, the relationship between the NRP and NPS peak positions was mathematically analyzed. Results Each NRT has its own unique NRP. By comparing the NPS and NRP for each NRT, it was found that NRP is related to the peak shift of NPS. Additionally, under the assumption that the NPS has one peak and is differentiable, a relationship was mathematically derived between the slope of the NRP at the peak position of the NPS before noise reduction and the shift of the NPS peak position after noise reduction. Conclusions A new metric, NRP, was proposed based on NPS to objectively evaluate and compare methods for noise reduction in CT. The NRP can be used to compare the effects of various NRTs on image noise in both the xy-plane and z-direction. It also enables unbiased assessment of the detailed noise reduction properties of each NRT over all relevant spatial frequencies. This article is protected by copyright. All rights reserved.

Objective The aim of the study was to evaluate the effect of slice thickness, iterative reconstruction (IR) algorithm, and kernel selection on measurement accuracy and interobserver variability for semiautomated renal cortex volumetry (RCV) with multislice computed tomography (CT). Methods Ten patients (62.4 ± 17.2 years) undergoing abdominal biphasic multislice computed tomography were enrolled in this retrospective study. Computed tomography data sets were reconstructed at 1-, 2-, and 5-mm slice thickness with 2 different IR algorithms (iDose, IMRST) and 2 different kernels (IMRS and IMRR) (Philips, the Netherlands). Two readers independently performed semiautomated RCV for each reconstructed data set to calculate left kidney volume (LKV) and split renal function (SRF). Statistics were calculated using analysis of variance with Geisser-Greenhouse correction, followed by Tukey multiple comparisons post hoc test. Statistical significance was defined as P ≤ 0.05. Results Semiautomated RCV of 120 data sets (240 kidneys) was successfully performed by both readers. Semiautomated RCV provides comparable results for LKV and SRF with 3 different slice thicknesses, 2 different IR algorithms, and 2 different kernels. Only the 1-mm slice thickness showed significant differences for LKV between IMRR and IMRS (P = 0.02, mean difference = 4.28 bb) and IMRST versus IMRS (P = 0.02, mean difference = 4.68 cm) for reader 2. Interobserver variability was low between both readers irrespective of slice thickness and reconstruction algorithm (0.82 ≥ P ≥ 0.99). Conclusions Semiautomated RCV measurements of LKV and SRF are independent of slice thickness, IR algorithm, and kernel selection. These findings suggest that comparisons between studies using different slice thicknesses and reconstruction algorithms for RCV are valid.

Purpose: Retrospective evaluation and comparison of image quality generated by low-dose computed tomography (LDCT) from obese patients with urolithiasis using alternative reconstruction algorithms. Materials and methods: Twenty-five obese patients (body mass index [BMI]>25 kg/m2) underwent LDCT scans for suspected urolithiasis. The scans were recompiled using filtered-back projection (FBP), statistical iterative reconstruction (iDose) and iterative model-based reconstruction (IMR). Dose-length product (DLP) and patient details were obtained from the CT dose report and clinical charts, respectively. Objective image noise was assessed by measuring the SD of Hounsfield units (HUs) in defined locations. Additionally, subjective image evaluation was independently performed by two radiologists using a 3-point Likert scale. The inter-reviewer agreement of image quality was calculated. Results: Ureteral concretions were observed in all CT scans, two of which revealed bilateral stones. The assessed patients' mean BMI was 29.29±3.74 kg/m2, and the DLP of the CT scans was 100.04±10.00 mGy*cm. All scans were rated diagnostic with the iDose and iterative model-based reconstructions, whereas 41% of the scans performed with FBP reconstruction were nondiagnostic. With respect to image quality, IMR was superior to iDose and FBP, both in the objective (P

Different glycoside based pseudodendrimeric (PD) structures were investigated computationally by using molecular dynamics approach. Studying were done at 37 and 42 °C to evaluate the response of the systems to the temperature. The monomers were attached to the C60 to create G4–6 structures. Studying Rg values cleared that structures show a response to the temperature. Between the G4 structures idose, lyxose, and mannose are showing an expansion by increasing temperature. In G5 structures, altrose, arabinose, and ribose are acting in that way. The glucose, lyxose, ribose, talose, and xylose in G6 structures are the best from the expansion of structure by increasing of temperature point of view. Considering these statements, the lyxose and ribose are more potent to show expansion by increasing temperature that is the desired behavior in temperature stimuli drug delivery approach. Also, it was found that there is a direct relation between the number of the hydrogen bonding interactions and compactness of structure. The layer based Rg values showed that G5 and G6 are showing the most amount of back-folding behavior. Molecular dynamic (MD(simulation studied and molecular mechanics/generalized Born surface area (MM/GBSA) calculations were used to study the release of seven drugs including afatinib, alitretinoin, altretamine, azacitidine, bexarotene, bicalutamide, and chlorambucil via temperature-responsive manner by using lyxose- and ribose-PDs. The results showed that G4 of ribose-PD is suitable for the release of afatinib, altretamine, and bicalutamide. The G5 of lyxose-PD can be used for the release of azacitidine and chlorambucil. The G6 of lyxose-PD and G5 of ribose-PD are appropriate for the release of alitretinoin and bexarotene, respectively. The van der Waals and electrostatic interactions and not the hydrogen bonding one is playing roles on the tighter and looser attachment of drugs to the PDs at lower and higher temperatures respectively. By considering the presented results, it is possible to select the suitable PDs for delivery of a drug by comparing the structure of the target drug with the drugs that have been studied in the present study. It can reduce the time and money that should be used to perform the experimental studies.

Purpose The purpose of this study was to characterize the technical capabilities and feasibility of a large field-of-view clinical spectral photon-counting computed tomography (SPCCT) prototype for high-resolution (HR) lung imaging. Materials and methods Measurement of modulation transfer function (MTF) and acquisition of a line pairs phantom were performed. An anthropomorphic lung nodule phantom was scanned with standard (120 kVp, 62 mAs), low (120 kVp, 11 mAs), and ultra-low (80 kVp, 3 mAs) radiation doses. A human volunteer underwent standard (120 kVp, 63 mAs) and low (120 kVp, 11 mAs) dose scans after approval by the ethics committee. HR images were reconstructed with 1024 matrix, 300 mm field of view and 0.25 mm slice thickness using a filtered-back projection (FBP) and two levels of iterative reconstruction (iDose 5 and 9). The conspicuity and sharpness of various lung structures (distal airways, vessels, fissures and proximal bronchial wall), image noise, and overall image quality were independently analyzed by three radiologists and compared to a previous HR lung CT examination of the same volunteer performed with a conventional CT equipped with energy integrating detectors (120 kVp, 10 mAs, FBP). Results Ten percent MTF was measured at 22.3 lp/cm with a cut-off at 31 lp/cm. Up to 28 lp/cm were depicted. While mixed and solid nodules were easily depicted on standard and low-dose phantom images, higher iDose levels and slice thicknesses (1 mm) were needed to visualize ground-glass components on ultra-low-dose images. Standard dose SPCCT images of in vivo lung structures were of greater conspicuity and sharpness, with greater overall image quality, and similar image noise (despite a flux reduction of 23%) to conventional CT images. Low-dose SPCCT images were of greater or similar conspicuity and sharpness, similar overall image quality, and lower but acceptable image noise (despite a flux reduction of 89%). Conclusions A large field-of-view SPCCT prototype demonstrates HR technical capabilities and high image quality for high resolution lung CT in human.

Objectives This study aimed to evaluate the image quality of 7 iterative reconstruction (IR) algorithms in comparison to filtered back-projection (FBP) algorithm. Methods An anthropomorphic chest phantom was scanned on 4 computed tomography scanners and reconstructed with FBP and IR algorithms. Image quality of anatomical details - large/medium-sized pulmonary vessels, small pulmonary vessels, thoracic wall, and small and large lesions - was scored. Furthermore, general impression of noise, image contrast, and artifacts were evaluated. Visual grading regression was used to analyze the data. Standard deviations were measured, and the noise power spectrum was calculated. Results Iterative reconstruction algorithms showed significantly better results when compared with FBP for these criteria (regression coefficients/P values in parentheses): vessels (FIRST: -1.8/0.05, AIDR Enhanced

Purpose: The goal of this study was to quantify the effects of iterative reconstruction on radiomics features of normal anatomic structures on head and neck computed tomography (CT) scans. Methods: Regions of interest (ROI) containing five different tissue types and an ROI containing only air were extracted from CT scans of the head and neck from 108 patients. Each scan was reconstructed using three different iDose 4 reconstruction levels (2, 4, and 6) in addition to bone, thin slice (1-mm slice thickness), and thin-bone reconstructions. From each ROI in all reconstructions, 142 radiomic features were calculated. For each of the six ROIs, features were compared between combinations of iDose levels (2v4, 4v6, and 2v6) with a threshold of α = 0.05 after correcting for multiple comparisons ( p 0.00006 ). Features from iDose 4 - 2 reconstructions were also compared to bone, thin slice, and thin-bone reconstructions. Spearman's rank correlation coefficient, ρ , quantified the relative feature value agreement across iDose 4 reconstructions. Results: When comparing radiomics features across the three iDose 4 reconstruction levels, over half of all features reflected significant differences for all tissue types, while no features demonstrated significant differences when extracted from air ROIs. When assessing feature value agreement, at least 97% of features reflected excellent agreement ( ρ > 0.9 ) when comparing the three iDose levels for all ROIs. When comparing iDose 4 - 2 to bone, thin slice, and thin-bone reconstructions, more than half of all features demonstrated significant differences for all ROIs and 89 % of features reflected excellent agreement for all ROIs. Conclusion: Many radiomics features are dependent on the iterative reconstruction level, and the magnitude of this dependency is affected by the tissue from which features are extracted. For studies using images reconstructed using varying iDose 4 reconstruction levels, features robust to these should be used.

The purpose of the study was to assess the impact of iterative model reconstruction (IMR) on reader confidence with respect to stone detection and image quality in comparison to filtered back-projection (FBP) and iDose level 4 (iDose4) in abdominal MDCT with radiation doses below 2 mSv.For 32 consecutive patients with suspected ureteral stone disease, the raw data of unenhanced 256 slice MDCT (120 kV, 40 reference mAs, mean CTDIvol: 2.7 ± 0.8 mGy, mean DLP: 126 ± 38 mGy × cm) were reconstructed using a prototype version of IMR (levels 1 - 3), iDose4 (level 4) and FBP at a 3 mm slice thickness. Image analysis was independently performed by two radiologists in a blinded fashion. The reader confidence level with respect to stone detection was recorded based on a 5-point scale (1 - certain exclusion; 5 - concrement definitely present) as well as for the evaluation of image quality regarding the depiction of anatomical details (1 - poor; 5 - excellent). A clinical reference standard for stone detection was not established. Statistical evaluation included weighted kappa analysis and Wilcoxon test.17 pelvic and ureteral stones were found. 11 further concrements were located within the ostium of the urinary bladder or the bladder itself. Applying IMR, a distinct improvement in image quality was observed at every level (mean value for FBP, 2.0; iDose4, 2.9; IMR L1, 4.2; IMR L2, 4.0; IMR L3, 3.9; all p 0.001). Applying the higher IMR levels L2 and L3, a certain level of so-called "blotchiness" of anatomical contours was observed. Reader confidence was significantly improved and was independent of IMR level (certain stone detection FBP, 69 %; iDose4, 81 %; IMR L1 to L3, 95 %; all p 0.001). With increasing IMR levels, the reduction in streak artifacts was quantified by a decrease in image noise. A loss of anatomical information was not observed. The sensitivity rates for stone detection were equivalent for all MDCTs reconstructed with FBP, iDose4 and IMR. A mean effective dose of 1.9 ± 0.6 mSv was calculated.In comparison to FBP and iDose4, a significant increase in mean image quality, reduction in image noise and improvement in subjective reader confidence can be achieved by applying IMR even at significantly reduced dose settings below 2 mSv. Results indicate that a further dose reduction might be possible with IMR.· Urinary tract. · urolithiasis. · iterative reconstruction.· Schmidt-Holtz J, Laqmani A, Butscheidt S et al. Iterative Model Reconstruction (IMR) in MDCT Below 2mSv for the Detection of Urinary Calculi: Diagnostic Accuracy and Image Quality in Comparison to Filtered Back-Projection and 4th Generation Iterative Reconstruction (iDose4). Fortschr Röntgenstr 2018; 190: 630 - 636.ZIEL: Das Ziel dieser Studie war es, die Auswirkungen der iterativen Modellrekonstruktion (IMR) auf die Sicherheit des Radiologen bei der Steindetektion und auf die Bildqualität im Vergleich zu gefilterten Rückprojektionen (FBP) und iDose Level 4 (iDose4) im Stein-MDCT mit Strahlendosen unter 2 mSv zu beurteilen.Für 32 aufeinanderfolgende Patienten mit Verdacht auf ein Harnleiterkonkrement wurden die Rohdaten der nativen Scans (256 Slice MDCT, 120 kV, 40 Referenz mAs, mittleres CTDIvol: 2,7 ± 0,8 mGy, mittleres DLP: 126 ± 38 mGy × cm) unter Verwendung einer Prototypversion von IMR (Level 1 – 3), iDose4 (Level 4) und FBP mit einer Schichtdicke von 3 mm rekonstruiert. Die Bildanalyse wurde jeweils unabhängig von zwei geblindeten Radiologen durchgeführt. Die diagnostische Sicherheit des Radiologen bei der Steindetektion erfolgte auf der Grundlage einer 5-Punkte-Skala (1 – sicherer Ausschluss, 5 – Konkrement definitiv vorhanden) wie auch für die Auswertung der Bildqualität in Bezug auf die Darstellung von anatomischen Details (1 – mangelhaft; 5 – Ausgezeichnet). Ein klinischer Referenzstandard für die Steindetektion wurde nicht erhoben. Die statistische Auswertung beinhaltet die weighted kappa-analysis und den Wilcoxon-Test.17 Nierenbecken- und Uretersteine wurden gefunden. 11 weitere Konkremente wurden im Harnblasenostium oder der Harnblase selber lokalisiert. Bei der Anwendung von IMR wurde mit jeder Iterationsstufe eine deutliche Verbesserung der Bildqualität beobachtet (Mittelwert für FBP, 2,0, iDose4, 2,9, IMR L1, 4,2, IMR L2, 4,0, IMR L3, 3,9, alle p 0,001). Mit den höheren IMR-Stufen L2 und L3 wurde ein gewisses Maß an sogenannter „blotchiness“ (Unschärfe) anatomischer Konturen beobachtet. Die Sicherheit des Radiologen wurde so unabhängig vom IMR-Level signifikant verbessert (sichere Steindetektion FBP, 69 %; iDose4, 81 %; IMR L1 bis L3, 95 %, alle p 0,001). Mit zunehmenden IMR-Werten wurde die Reduktion von Streifenartefakten durch eine Abnahme des Bildrauschens quantifiziert. Ein Verlust anatomischen Informationen wurde nicht beobachtet. Die Sensitivität der Steindetektion waren äquivalent für alle MDCTs, die mit FBP, iDose4 oder IMR rekonstruiert wurden. Es wurde eine mittlere effektive Dosis von 1,9 ± 0,6 mSv berechnet.Eine Urolithiasis kann zuverlässig durch MDCT bei deutlich reduzierten Dosiseinstellungen unter 2 mSv detektiert werden. Im Vergleich zu FBP und iDose4 kann eine signifikante Erhöhung der durchschnittlichen Bildqualität, eine Verringerung des Bildrauschens und eine Verbesserung der subjektiven diagnostischen Sicherheit des Radiologen bei der Konkrementdetektion mit Hilfe von IMR erreicht werden. Dies deutet darauf hin, dass mit IMR weiterreichende Dosisreduktionen möglich sein könnten.· Urogenitaltrakt. · Urolithiasis. · Iterative Reconstruction.

Several l-idose and l-iduronic acid glycosyl donors (mostly thioglycosides but also halides and trichloroacetimidates) with acyl protecting groups at the C-2 position were prepared and evaluated in glycosylation reactions with simple acceptors. In glycosaminoglycan oligosaccharide syntheses in the literature, the presence of C-2 acyl protecting groups in l-ido-configured glycosyl donors generally results in exclusive formation of 1,2-trans glycosidic linkages, a finding that has typically been attributed to neighbouring-group participation. However, glycosylations of simple alcohols with l-ido-configured donors (particularly thioglycosides), reported here, generally displayed incomplete stereocontrol and gave mixtures of the 1,2-trans and 1,2-cis products, suggesting that neighbouring-group participation has lesser importance in these reactions. Glycosyl donors and reaction conditions were identified that gave improved, but not exclusive, selectivity for the desired α-l-anomer (1,2-trans) as the major product. Interestingly, glycosylations under the same reaction conditions with more complex monosaccharide acceptors gave exclusively the expected 1,2-trans products. The role of neighbouring-group participation in these glycosylations was explored with density functional theory (DFT) calculations, which revealed that the non-stereoselective addition of the acceptor alcohol to the intermediate oxocarbenium ion is competitive with the stereospecific addition of the acceptor to the acyloxonium ion intermediate.

Rationale and Objectives This study aimed to evaluate the correlation of quantitative measurements with visual grading regression (VGR) and receiver operating characteristics (ROC) analysis in computed tomography (CT) images reconstructed with iterative reconstruction. Materials and Methods CT scans on a liver phantom were performed on CT scanners from GE, Philips, and Toshiba at three dose levels. Images were reconstructed with filtered back projection (FBP) and hybrid iterative techniques (ASiR, iDose, and AIDR 3D of different strengths). Images were visually assessed by five readers using a four- and five-grade ordinal scale for liver low contrast lesions and for 10 image quality criteria. The results were analyzed with ROC and VGR. Standard deviation, signal-to-noise ratios, and contrast-to-noise ratios were measured in the images. Results All data were compared to FBP. The results of the quantitative measurements were improved for all algorithms. ROC analysis showed improved lesion detection with ASiR and AIDR and decreased lesion detection with iDose. VGR found improved noise properties for all algorithms, increased sharpness with iDose and AIDR, and decreased artifacts from the spine with AIDR, whereas iDose increased the artifacts from the spine. The contrast in the spine decreased with ASiR and iDose. Conclusions Improved quantitative measurements in images reconstructed with iterative reconstruction compared to FBP are not equivalent to improved diagnostic image accuracy.

To assess the impact of iterative reconstruction and filtered back projection (FBP) on image quality in computed tomography (CT)-based forensic age estimation of the medial clavicular epiphysis. CT of the clavicle was performed in 19 patients due to forensic reasons (70 mAs/140 kVp). Raw data were reconstructed with FBP and with an iterative algorithm at level 4 and 6. Clavicular ossification stage was determined by two radiologists in consensus, firstly on FBP reconstructed images and secondly after reviewing all reconstructions including iDose 4 and 6. In addition, the 3 reconstructions were compared regarding artefacts and delineation of the meta-/epiphyseal interface. Quantitative image noise was measured. Quantitative noise was lower in iDose 6 reconstructed images than in FBP (P < 0.042), but not significantly lower between iDose 4 and FBP (P = 0.127). Side by side comparison revealed lesser qualitative image noise on both iDose reconstructed images than for FBP. The meta-/epiphyseal interface delineation was rated better on both iDose levels than with FBP. In 3 of 19 patients, the clavicular ossification stage was reclassified after iterative reconstructions had been additionally reviewed. Using iterative CT reconstruction algorithms, a reduction of image noise and an enhancement of image quality regarding the meta-/epiphyseal clavicular interface can be achieved. The study highlights the importance of image standardization as variation of reconstruction technique has impact on forensic age estimation.

An efficient protocol for preparation of rare L-idose derivatives from 5-OH D-glucofuranose derivatives was developed, and the stereo-inversion of 5-OH was assisted by neighboring acyl group. A library of L-idose derivatives with various protective groups at C3 and C6 positions were obtained from the corresponding D-glucofuranose derivatives in good to high yields, which provides an alternative approach for the synthesis of L-iduronic acid building blocks when assembling heparin-like oligosaccharides. And the mechanism of the stereo-inversion reaction was proposed.

Objective To compare both image quality and visibility of normal and abnormal findings at submillisievert chest CT (smSv-CT) using filtered back projection (FBP) and the two different iterative reconstruction (IR) techniques iterative model reconstruction (IMR) and iDose 4 ™. Materials and methods This institutional review board approved study was based on retrospective interpretation of clinically indicated acquired data. The requirement to obtain informed consent was waived. 81 patients with suspected pneumonia underwent smSv-CT (Brilliance iCT, Philips Healthcare; mean effective dose: 0.86±0.2mSv). Data were reconstructed using FBP and two different IR techniques iDose 4 ™ and IMR (Philips Healthcare) at various iteration levels. Objective image noise (OIN) was measured. Two experienced readers independently assessed all images for image noise, image appearance and visibility of normal anatomic and abnormal findings. A random intercept model was used for statistical analysis. Results Compared to FBP and iDose 4 ™, IMR reduced OIN up to 88% and 72%, respectively (p 4 ™ images provided satisfactory to good image quality for visibility of normal and abnormal findings and were superior to FBP (p 4 ™, while being superior for visibility of abnormal findings except for reticular pattern (p Conclusion IMR results for visibility of normal and abnormal lung findings are heterogeneous, indicating that IMR may not represent a priority technique for clinical routine. iDose 4 ™ represents a suitable method for evaluation of lung tissue at submillisievert chest CT.

The design of 6-azido-6-deoxy-l-idose for use as a hetero-bifunctional spacer is reported. The hemiacetal at one terminus is an equivalent of an aldehyde and can react with nucleophiles, such as amino groups and electron-rich aromatics. The azido group at the other terminus bio-orthogonally undergoes a Hüisgen [3+2] cycloaddition with an acetylene. The idose derivative exhibited a higher level of reactivity towards oxime formation than a corresponding glucose derivative. The (13) C NMR spectrum of the uniformly (13) C-labeled 6-azido-idose indicated that the acyclic forms of the sugar totaled 0.3 % of all the isomers, whereas those of glucose totaled 0.01 %. The larger population of the acyclic forms of the idose derivative would result in higher reactivity towards electrophilic addition in comparison with glucose derivatives. Finally, we prepared a C-idosyl epigallocatechin gallate (EGCG) that bears an azido group through C-glycosylation of EGCG with 6-azido-idose. This glycosyl form of the C-idosyl EGCG exhibited a cytotoxicity against U266 cells that was comparable to that of EGCG. These results suggested that the EGCG derivative could be used as an effective chemical probe for the elucidation of EGCG biological functions.

Purpose High radiosensitivity of children undergoing repetitive computed tomography examinations necessitates the use of iterative reconstruction algorithms in order to achieve a significant radiation dose reduction. The goal of this study is to compare the iDose iterative reconstruction algorithm with filtered backprojection in terms of radiation exposure and image quality in 33 chest high-resolution computed tomography examinations performed in young children with chronic bronchitis. Methods Fourteen patients were scanned using the filtered backprojection protocol while 19 patients using the iDose protocol and reduced milliampere-seconds, both on a 64-detector row computed tomography scanner. The iDose group images were reconstructed with different iDose levels (2, 4, and 6). Radiation exposure quantities were estimated, while subjective and objective image qualities were evaluated. Unpaired t tests were used for data statistical analysis. Results The iDose application allowed significant effective dose reduction (about 80%). Subjective image quality evaluation showed satisfactory results even with iDose level 2, whereas it approached excellent image with iDose level 6. Subjective image noise was comparable between the 2 groups with the use of iDose level 4, while objective noise was comparable between filtered backprojection and iterative reconstruction level 6 images. Conclusions The iDose algorithm use in pediatric chest high-resolution computed tomography reduces radiation exposure without compromising image quality. Further evaluation with iterative reconstruction algorithms is needed in order to establish high-resolution computed tomography as the gold standard low-dose method for children suffering from chronic lung diseases.

The purpose of this report is to describe our experience with the implementation of a practice quality improvement (PQI) project in thoracic imaging as part of the American Board of Radiology Maintenance of Certification process. The goal of this PQI project was to reduce the effective radiation dose of routine chest CT imaging in a busy clinical practice by employing the iDose(4) (Philips Healthcare) iterative reconstruction technique. The dose reduction strategy was implemented in a stepwise process on a single 64-slice CT scanner with a volume of 1141 chest CT scans during the year. In the first annual quarter, a baseline effective dose was established using the standard filtered back projection (FBP) algorithm protocol and standard parameters such as kVp and mAs. The iDose(4) technique was then applied in the second and third annual quarters while keeping all other parameters unchanged. In the fourth quarter, a reduction in kVp was also implemented. Throughout the process, the images were continually evaluated to assure that the image quality was comparable to the standard protocol from multiple other scanners. Utilizing a stepwise approach, the effective radiation dose was reduced by 23.62 and 43.63% in quarters two and four, respectively, compared to our initial standard protocol with no perceived difference in diagnostic quality. This practice quality improvement project demonstrated a significant reduction in the effective radiation dose of thoracic CT scans in a busy clinical practice.

To evaluate the image quality of ultralow-dose computed tomography (ULDCT) reconstructed with knowledge-based iterative model reconstruction (IMR) in patients with pulmonary tuberculosis (TB). This IRB-approved prospective study enrolled 59 consecutive patients (mean age, 43.9 ± 16.6 years; F:M 18:41) with known or suspected pulmonary TB. Patients underwent a low-dose CT (LDCT) using automatic tube current modulation followed by an ULDCT using fixed tube current. Raw image data were reconstructed with filtered-back projection (FBP), hybrid iterative reconstruction (iDose), and IMR. Objective measurements including CT attenuation, image noise, and contrast-to-noise ratio (CNR) were assessed and compared using repeated-measures analysis of variance. Overall image quality and visualization of normal and pathological findings were subjectively scored on a five-point scale. Radiation output and subjective scores were compared by the paired Student t test and Wilcoxon signed-rank test, respectively. Compared with FBP and iDose, IMR yielded significantly lower noise and higher CNR values at both dose levels (p

To evaluate the effect of radiation dose reduction and iterative reconstruction (IR) on the performance of computer-aided detection (CAD) for pulmonary nodules.In this prospective study twenty-five patients were included who were scanned for pulmonary nodule follow-up. Image acquisition was performed at routine dose and three reduced dose levels in a single session by decreasing mAs-values with 45%, 60% and 75%. Tube voltage was fixed at 120 kVp for patients ≥ 80 kg and 100 kVp for patients80 kg. Data were reconstructed with filtered back projection (FBP), iDose(4) (levels 1,4,6) and IMR (levels 1-3). All noncalcified solid pulmonary nodules ≥ 4 mm identified by two radiologists in consensus served as the reference standard. Subsequently, nodule volume was measured with CAD software and compared to the reference consensus. The numbers of true-positives, false-positives and missed pulmonary nodules were evaluated as well as the sensitivity.Median effective radiation dose was 2.2 mSv at routine dose and 1.2, 0.9 and 0.6 mSv at respectively 45%, 60% and 75% reduced dose. A total of 28 pulmonary nodules were included. With FBP at routine dose, 89% (25/28) of the nodules were correctly identified by CAD. This was similar at reduced dose levels with FBP, iDose(4) and IMR. CAD resulted in a median number of false-positives findings of 11 per scan with FBP at routine dose (93% of the CAD marks) increasing to 15 per scan with iDose(4) (95% of the CAD marks) and 26 per scan (96% of the CAD marks) with IMR at the lowest dose level.CAD can identify pulmonary nodules at submillisievert dose levels with FBP, hybrid and model-based IR. However, the number of false-positive findings increased using hybrid and especially model-based IR at submillisievert dose while dose reduction did not affect the number of false-positives with FBP.

Computed tomography (CT) is one of the most important modalities in a radiological department. This technique not only produces images that enable radiological reports with high diagnostic confidence, but it may also provide an elevated radiation dose to the patient. The radiation dose can be reduced by using advanced image reconstruction algorithms. This study was performed on a Brilliance iCT, equipped with iDose(4) iterative reconstruction and an iterative model-based reconstruction (IMR) method. The purpose was to investigate the effect of reduced slice thickness combined with an IMR method on image quality compared with standard slice thickness with iDose(4) reconstruction. The results of objective and subjective image quality evaluations showed that a thinner slice combined with IMR can improve the image quality and reduce partial volume artefacts compared with the standard slice thickness with iDose(4). In conclusion, IMR enables reduction of the slice thickness while maintaining or even improving image quality versus iDose(4).

To evaluate the feasibility of a 100 kVp tube voltage combined with an iterative reconstruction algorithm in retrospective electrocardiogram (ECG)-gated thoracoabdominal aortic CT angiography (CTA).Ninety-eight patients who underwent clinically indicated thoracoabdominal aortic CTA were randomly assigned to two groups: group A (n = 50) were scanned to 120 kVp and group B (n = 48) to 100 kVp. The body mass index of all included patients was25 kg/m(2). Group A scans were reconstructed with a standard filtered back projection (FBP) algorithm, and group B scans with FBP, iDose, and non-tagged algorithms. Data comparison between groups was performed using t-test and analysis of variance.Compared with group A, the iDose algorithm in group B yielded a higher contrast-to-noise ratio (CNR; 48.1 ± 10.1, p0.05), a higher signal-to-noise ratio (SNR; 13.8 ± 5.4, p0.05), and a lower standard deviation (SD; 30.3 ± 6.9, p0.05). The subjective score of iDose reconstructions from group B was significantly lower than that of FBP reconstruction from group A (p0.05). In group B, the non-tagged algorithm resulted in a higher CNR and a higher SNR, but a higher SD and a higher subjective score than did the iDose algorithm. The average effective dose for group B was 35.8% lower than that for group A.A combination of a 100 kVp tube voltage and the iDose algorithm can help to improve image quality and reduce radiation dose in retrospective ECG-gated thoracoabdominal aortic CTA.

Purpose: Hyperdense artery sign is the earliest sign of ischemic stroke on non-enhanced computed tomography and it can be visible long before parenchymal changes. The aim of our study was to compare diagnostic value of model-based iterative reconstruction algorithm (IMR) with that of iterative reconstruction algorithm (iDose4) in identifying hyperdense artery sign. Methods: We selected 56 consecutive patients suspected for ischemic stroke, who underwent a NCCT and that demonstrated a vessel occlusion at angio-CT or developed ischemic lesion at follow-up CT. Two readers randomly analyzed images of NCCT reconstructed both with iDose4 (4 mm) and IMR (2 mm), reporting presence of hyperdense artery sign (0: no; 1: yes; 2: not sure). They rated image quality on a 4-point scale (1: unacceptable; 4: more than average) and recorded HU values of clot and of normal vessel and measured noise index, CNR and SNR. Results: Mean values of CTDI, DLP, and ED were respectively of 43 mGy, 819.7 mGy cm, and 1.72 mSv. By analyzing the IMR reconstruction, both readers were able to recognize hyperdense vessel sign in 55/56 patients, while only in 12/56 patients were identified with iDose. IMR obtained better rating of image quality (mean score for IMR 3.32 vs 2.53 for iDose), higher clot density (57.2 vs 46.7 HU), lower noise index (5 vs 2), higher CNR and SNR (respectively 4.2 vs 2 and 16.8 vs 8.5). Conclusions: Model-based approach significantly increases sensitivity in detecting hyperdense artery sign, offering higher SNR and CNR in brain CT images in comparison with standard hybrid reconstruction algorithm

PURPOSE To assess lesion detection and image quality of ultralow-dose (ULD) abdominal computed tomography (CT) reconstructed with filtered back projection (FBP) and 2 iterative reconstruction techniques: hybrid-based iDose, and image-based SafeCT. MATERIALS AND METHODS In this institutional review board-approved ongoing prospective clinical study, 41 adult patients provided written informed consent for an additional ULD abdominal CT examination immediately after standard dose (SD) CT exam on a 256-slice multidetector computed tomography (iCT, Philips-Healthcare). The SD examination (size-specific dose estimate, 10 ± 3 mGy) was performed at 120 kV with automatic exposure control, and reconstructed with FBP. The ULD examination (1.5 ± 0.4 mGy) was performed at 120 kV and fixed tube current of 17 to 20 mAs/slice to achieve ULD radiation dose, with the rest of the scan parameters same as SD examination. The ULD data were reconstructed with (a) FBP, (b) iDose, and (c) SafeCT. Lesions were detected on ULD FBP series and compared to SD FBP "reference-standard" series. True lesions, pseudolesions, and missed lesions were recorded. Four abdominal radiologists independently blindly performed subjective image quality. Objective image quality included image noise calculation and noise spectral density plots. RESULTS All true lesions (n, 52: liver metastases, renal cysts, diverticulosis) in SD FBP images were detected in ULD images. Although there were no missed or pseudolesions on ULD iDose and ULD SafeCT images, appearance of small low-contrast hepatic lesions was suboptimal. The ULD FBP images were unacceptable across all patients for both lesion detection and image quality. In patients with a body mass index (BMI) of 25 kg/m or less, ULD iDose and ULD SafeCT images were acceptable for image quality that was close to SD FBP for both normal and abnormal abdominal and pelvic structures. With increasing BMI, the image quality of ULD images was deemed unacceptable due to photo starvation. Evaluation of kidney stones with ULD iDose/SafeCT images was found acceptable regardless of patient size. Image noise levels were significantly lower in ULD iDose and ULD SafeCT images compared to ULD FBP (P < 0.01). CONCLUSIONS Preliminary results show that ULD abdominal CT reconstructed with iterative reconstruction techniques is achievable in smaller patients (BMI ≤ 25 kg/m) but remains a challenge for overweight to obese patients. Lesion detection is similar in full-dose SD FBP and ULD iDose/SafeCT images, with suboptimal visibility of low-contrast lesions in ULD images.

Objective Although advanced statistical iterative reconstruction (IR) techniques are valued in pediatric computed tomography (CT) imaging, there is little published data on how these techniques affect image quality and radiation dose in the pediatric population. This is particularly true in the context of pediatric head CT examinations. This study analyzed the differences in image quality and several standard metrics of radiation dose on multidetector pediatric head CT examinations performed using standard filtered back projection (FBP) with reconstructions using iDose, a fourth-generation statistical iterative reconstruction technique. Materials and methods Using a retrospective review of 282 pediatric head CT examinations, we compared how iDose fared against FBP for effects on several standard metrics of radiation dose and qualitative and quantitative assessment of image quality. Results Our assessment revealed that examinations obtained using low-dose protocols reconstructed using iDose, when compared with standard-dose examinations reconstructed using FBP, resulted in significant radiation dose reduction while performing equally or better in quantitative image quality parameters. For most qualitative image quality parameters, the iDose group demonstrated equal performance to standard filtered back technique with a few notable exceptions. In the parameter of image sharpness in the 1.5 to 7 year olds, iDose fared better than FBP. However, FBP outperformed iDose in the qualitative parameters of decreased image graininess/noise in patients older than 13 years, improved image sharpness in patients aged between 7 and 13 years, and improved visibility of small parts for those aged 7 to 13 years. Conclusions We conclude that iDose is effective at allowing significant radiation dose reduction while maintaining or, rarely, even improving quantitative image quality compared with FBP in the setting of pediatric head CT examinations. However, for certain qualitative image quality parameters in older-aged children, the use of iDose resulted in a poorer performance compared with FBP.

This study aims to investigate the effect of iterative reconstruction (IR) on MDCT image quality and radiologists’ ability to diagnose and grade blunt solid organ injuries. One hundred (100) patients without and 52 patients with solid organ injuries were scanned on a 64-slice MDCT scanner using reference 300 mAs, 120 kVp, and fixed 75 s delay. Raw data was reconstructed using filtered back projection (FBP) and three levels of iterative reconstruction (Philips iDose levels 2, 4, and 6). Four emergency radiologists, blinded to the reconstruction parameters and original interpretation, independently reviewed each case, assessed image quality, and assigned injury grades. Each reader was then asked to determine if they thought that IR was used and, if so, what level. There was no significant difference in diagnostic accuracy between FBP and the various IR levels or effect on the detection and grading of solid organ injuries (p > 0.8). Images reconstructed using iDose level 2 were judged to have the best overall image quality (p < 0.01). The radiologists had high sensitivity in detecting if IR was used (80 %, 95 % CI 76–84 %). IR performed comparably to FBP with no effect on radiologist ability to accurately detect and grade blunt solid organ injuries.

Purpose To evaluate the influence of radiation dose settings and reconstruction algorithms on the measurement accuracy and reproducibility of semi-automated pulmonary nodule volumetry. Materials and methods CT scans were performed on a chest phantom containing various nodules (10 and 12mm; +100, −630 and −800HU) at 120kVp with tube current–time settings of 10, 20, 50, and 100mAs. Each CT was reconstructed using filtered back projection (FBP), iDose 4 and iterative model reconstruction (IMR). Semi-automated volumetry was performed by two radiologists using commercial volumetry software for nodules at each CT dataset. Noise, contrast-to-noise ratio and signal-to-noise ratio of CT images were also obtained. The absolute percentage measurement errors and differences were then calculated for volume and mass. The influence of radiation dose and reconstruction algorithm on measurement accuracy, reproducibility and objective image quality metrics was analyzed using generalized estimating equations. Results Measurement accuracy and reproducibility of nodule volume and mass were not significantly associated with CT radiation dose settings or reconstruction algorithms ( p >0.05). Objective image quality metrics of CT images were superior in IMR than in FBP or iDose 4 at all radiation dose settings ( p Conclusion Semi-automated nodule volumetry can be applied to low- or ultralow-dose chest CT with usage of a novel iterative reconstruction algorithm without losing measurement accuracy and reproducibility.

We compared image quality in 44 pediatric head computed tomographic exams reconstructed using four levels of blended iterative techniques (iDOSE 1-4) versus filtered back projection. Three radiologists reviewed the 220 series in a randomized, blinded manner. They scored each series based on gray-white matter differentiation, visibility of the pre-pontine cistern, caudate head, image noise, and image quality. Noise was measured in the vitreous and the thalamus. Composite scores were highest with iDOSE 4 (P

A practical synthesis of the very rare sugar d-idose and the stable building blocks for d-idose, d-iduronic, and d-idonic acids from ido-heptonic acid requires only isopropylidene protection, Shing silica gel-supported periodate cleavage of the C6-C7 bond of the heptonic acid, and selective reduction of C1 and/or C6. d-Idose is the most unstable of all the aldohexoses and a stable precursor which be stored and then converted under very mild conditions into d-idose is easily prepared.

PURPOSE This study aimed to determine whether an iterative model-based reconstruction (IMR) can improve lesion conspicuity and depiction on computed tomography (CT) compared with filtered back projection (FBP) and hybrid iterative reconstruction (iDose) using anthropomorphic phantoms. MATERIALS AND METHODS One small and one large anthropomorphic body phantoms, each containing 8 simulated focal liver lesions (FLLs), were scanned using a 256-channel CT scanner at 120 kVp with variable tube current-time products (10-200 mAs). Scans were divided into 3 groups based on radiation dose (RD) as follows: (a) full dose (FD), (b) low dose (FD50), and (c) ultralow dose (FD25 for the large phantom, FD15 for the small phantom). All images were reconstructed using FBP, iDose, and IMR. Image noise and lesion-to-liver contrast were assessed quantitatively and qualitatively. Thereafter, 6 radiologists independently evaluated conspicuity of FLLs, and then, compared the number of invisible FLLs on 3 image sets of each RD group. RESULTS Image noise was significantly lower with IMR than with FBP and iDose at the same RD. Iterative model-based reconstruction improved conspicuity of low-contrast FLLs in all RD groups compared to the others (P < 0.001). Furthermore, compared to FBP and iDose, the number of visible FLLs significantly increased on IMR images in the FD15 group of the small phantom 52.8% [38/72], 68.1% [49/72], and 84.8% [61/72], respectively; P < 0.001) and in the FD 25, FD50 groups of the large phantom (FD50: 56.9% [41/72], 76.4% [55/72], and 84.7% [61/72], respectively; P < 0.05). CONCLUSIONS Iterative model-based reconstruction reduced image noise and improved low-contrast FLL conspicuity, compared to FBP and iDose. Therefore, depiction of low-contrast FLLs on FBP could be improved using IMR.

OBJECTIVES The aims of this study were to compare a commercially available reconstruction algorithm (iDose4) with filtered back projection (FBP) in terms of image quality (IQ) for both retrospective electrocardiographically gated and prospective electrocardiographically triggered cardiac computed tomographic angiography (CCTA) protocols and to evaluate the achievable radiation dose reduction. METHODS A total cohort of 58 patients underwent either prospective CTCA or retrospective CTCA with full or reduced tube current-time product (in milliampere-second) protocol on a 64-slice multidetector computed tomographic scanner. All images were reconstructed with FBP, whereas the reduced milliampere-second images were also reconstructed using 2 levels (levels 4 and 6) of iDose4. Subjective and objective IQ was evaluated. RESULTS Dose reductions of 43% in the retrospective CCTA protocol and 27% in the prospective CCTA protocol were achieved without compromising IQ. In the prospective CCTA protocol, the reduced-dose images were highly scored; thus, additional reduction of exposure settings is feasible. In the retrospective acquisition, dose reduction has led to similar IQ scores between the reduced-dose iDose4 images and the full-dose FBP images. Considering different reconstructions (FBP, iDose-L4 and -L6) of the same acquisition data, increase in iDose4 level resulted in less noisy images. A slight improvement was also noticed in all IQ indices; however, this improvement was not statistically significant for both acquisition protocols. CONCLUSIONS This study demonstrated that the application of iDose at CCTA facilitates significant radiation dose reduction by maintaining diagnostic quality. The combination of iDose4 with prospective acquisition is able to significantly reduce effective dose associated with CTCA at values of approximately 2 mSv and even lower.

PURPOSE To assess lesion detection and diagnostic confidence of computed tomography (CT) of the chest performed at less than 1 mSv with 2 iterative reconstruction (IR) techniques. MATERIALS AND METHODS Ten patients gave written informed consent for the acquisitions of images at submillisievert dose (0.9 mSv), in addition to clinical standard-dose (SD) chest CT (2.9 mSv). Submillisievert images were reconstructed with iDose and iterative model reconstruction (IMR). Two radiologists assessed lesion detection, margins, diagnostic confidence, and visibility of small structures. Objective noise and noise spectral density were measured. RESULTS Lesion detection was identical for standard-dose filtered back projection (FBP), submSv iDose, and submSv IMR. Lesion margins were better seen for 30% of detected lung lesions with submSv IMR compared to standard-dose FBP and submSv iDose (P < 0.05). Visibility of abdominal structures, and diagnostic confidence with submSv iDose and submSv IMR were similar to standard-dose FBP. There was 21% to 64% noise reduction with submSv IMR and 1% to 15% higher noise with iDose compared to standard-dose FBP (P < 0.0001). CONCLUSIONS Submillisievert IMR improves delineation of lesion margins compared to standard-dose FBP and submSv iDose.

The aim of this study is to evaluate the effect of iDose(4) iterative reconstruction algorithm on radiation dose and imaging quality at chest-abdomen-pelvis (CAP) CT examinations. Seventeen patients were considered; all patients had a previous CT scan with the standard filter back-projection (FBP) protocol and a follow-up scan with the iDose(4) protocol at the same scanner. Image noise, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were objectively calculated. Two radiologists evaluated noise, sharpness, contrast, diagnostic confidence and artefacts. Radiation exposure quantities were calculated. iDose(4) resulted in 46 % dose reduction combined with significantly lower noise and higher SNR and CNR compared with FBP. iDose(4) images had significantly lower subjective image noise and enhanced sharpness and contrast. Diagnostic confidence was high and image artefacts were minor for both algorithms. iDose(4) provides great potential for reducing patient radiation burden while improving imaging quality in CAP CT examinations.

Glycan arrays have been established as the premier technical platform for assessing the specificity of carbohydrate binding proteins, an important step in functional glycomics research. Access to large libraries of well-characterized oligosaccharides remains a major bottleneck of glycan array research, and this is particularly true for glycosaminoglycans (GAGs), a class of linear sulfated polysaccharides which are present on most animal cells. Solid-supported synthesis is a potentially powerful tool for the accelerated synthesis of relevant GAG libraries with variations in glycan sequence and sulfation pattern. We have evaluated a series of iduronic acid and idose donors, including a couple of novel n-pentenyl orthoester donors in the sequential assembly of heparan sulfate precursors from monosaccharide building blocks in solution and on a polystyrene resin. The systematic study of donor and acceptor performance up to the trisaccharide stage in solution and on the solid support have resulted in a general strategy for the solid-phase assembly of this important class of glycans.

Carbohydrate–carbohydrate interactions (CCI) are mediated by complexation of metal ions. Angyal postulated on the requirements for hydroxy group arrangement in pyranoses to account for metal-ion complexation. These requirements are particularly well fulfilled in α-ido- and α-talopyranosides, whose ring hydroxy groups have all axial and axial-equatorial-axial configurations, respectively. Surface plasmon resonance (SPR) and gold-nanoparticle techniques have proved to be powerful tools to investigate CCIs. Benzaldehyde-functionalized glycans can be used for attachment to both gold nanoparticles and SPR sensor surfaces. Therefore, benzaldehyde-equipped ido- and talopyranosides were synthesized by the almost forgotten Paulsen acetoxonium rearrangement. This approach provides peracetylated idose and talose in only two steps from common glucose and galactose precursors, respectively, in overall yields of up to 41 % and, therefore, avoids long and laborious procedures to obtain these rare carbohydrates. The derivatives are being used in ongoing CCI studies using SPR to test Angyal's postulate about the structural requirements for hydroxy group arrangements.

The detection of ground-glass opacities (GGOs) is an important issue in lung cancer screening with low-dose CT. The iterative reconstruction (IR) technique has the ability to improve the image quality relative to the filtered back projection (FBP) technique with low-dose CT. Our purpose was to investigate the ability to detect GGO in a chest phantom using a low-dose CT and hybrid IR, named iDose. Simulated GGOs in a chest phantom were scanned with 256-section CT at tube current second products of 20, 50, 100, and 200 mAs. Five radiologists visually assessed the detectability of GGOs in the phantom. The contrast-to-noise ratio (CNR) for GGOs was used as an estimate of image quality. Comparison of the detectability and CNR between standard images with 200 mAs-FBP and low-dose images with 20, 50, and 100-mAs FBP/iDose were performed by ANOVA with Dunnett’s and Tukey’s test. The detectability was significantly lower at 20-mAs FBP/iDose and 50-mAs FBP than that at 200-mAs FBP (p < 0.05). There was no significant difference between 50-mAs iDose and 200-mAs FBP and between 100-mAs iDose/FBP and 200-mAs FBP. The CNR was significantly higher on iDose images than that on FBP images at each mAs value. The CNR at 200-mAs FBP was the same as that at 50-mAs iDose (CNR:1.8). The hybrid IR technique and low-dose CT imaging with 50 mAs enabled noise and to maintain the detectability for GGOs in a chest phantom that is equivalent to the reference acquisitions of 200 mAs with FBP.