8 results on '"IgE - Immunoglobulin E"'
Search Results
2. World allergy organization anaphylaxis guidance 2020
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Luciana Kase Tanno, Montserrat Fernandez Rivas, Alexei Gonzalez-Estrada, Aziz Sheikh, Stanley M. Fineman, Yehia El-Gamal, Ignacio J. Ansotegui, Victoria Cardona, Paul Turner, Motohiro Ebisawa, Mario Geller, Bernard Yu-Hor Thong, Paul A. Greenberger, Gianenrico Senna, Margitta Worm, Mario Sanchez Borges, Vall d'Hebron University Hospital [Barcelona], Allergy Unit [Malaga, Spain] (National Network ARADyAL), Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain], Hospital Quirónsalud Bizkaia [Bilbao], Sagamihara National Hospital [Kanagawa, Japan], Ain Shams University (ASU), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Emory University School of Medicine, Emory University [Atlanta, GA], Academia Nacional de Medicina, Mayo Clinic [Jacksonville], Northwestern University Feinberg School of Medicine, Centro Médico Docente La Trinidad, Clínica el Avila, Università degli studi di Verona = University of Verona (UNIVR), Usher Institute of Population Health Sciences and Informatics [Edinburgh, U.K.], University of Edinburgh, Hospital Sírio-Libanês [São Paulo, Brazil], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), INSERM-TRANSFERT [Paris] (IT), Institut National de la Santé et de la Recherche Médicale (INSERM), WHO-TDR Suisse, WHO-TDR Suisse-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Tan Tock Seng Hospital, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, School of Medicine [Western Sydney University], Western Sydney University, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], and Salvy-Córdoba, Nathalie
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Allergy ,0302 clinical medicine ,Immunology and Allergy ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,030223 otorhinolaryngology ,NSAIDs, nonsteroidal anti-inflammatory drugs ,IgE, immunoglobulin E ,CAST, cellular allergen stimulation test ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,BAT, basophil activation test ,EAI, epinephrine auto-injectors ,[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences ,Acute systemic allergic reaction ,Epinephrine ,ACE - Angiotensin-converting enzyme ,MRGPRX2, Mas-related G-protein coupled receptor member X2 ,Guidance ,Position Paper ,Venom allergy ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,Anaphylaxis ,medicine.drug ,lcsh:Immunologic diseases. Allergy ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Immunology ,Drug allergy ,IgG, immunoglobulin G ,FcεRI, IgE high-affinity receptor ,Guidelines ,Adrenaline ,03 medical and health sciences ,Food allergy ,medicine ,Intensive care medicine ,Glucocorticoids ,Health professionals ,business.industry ,Cofactors ,1103 Clinical Sciences ,medicine.disease ,ACE, Angiotensin converting enzyme ,IgE - Immunoglobulin E ,030228 respiratory system ,Antihistamines ,lcsh:RC581-607 ,business - Abstract
International audience; Anaphylaxis is the most severe clinical presentation of acute systemic allergic reactions. The occurrence of anaphylaxis has increased in recent years, and subsequently, there is a need to continue disseminating knowledge on the diagnosis and management, so every healthcare professional is prepared to deal with such emergencies. The rationale of this updated position document is the need to keep guidance aligned with the current state of the art of knowledge in anaphylaxis management. The World Allergy Organization (WAO) anaphylaxis guidelines were published in 2011, and the current guidance adopts their major indications, incorporating some novel changes. Intramuscular epinephrine (adrenaline) continues to be the first-line treatment for anaphylaxis. Nevertheless, its use remains suboptimal. After an anaphylaxis occurrence, patients should be referred to a specialist to assess the potential cause and to be educated on prevention of recurrences and self-management. The limited availability of epinephrine auto-injectors remains a major problem in many countries, as well as their affordability for some patients.
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- 2020
3. Medicinal benefits of Nigella sativa in bronchial asthma: A literature review
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Abdulrahman E. Koshak, Emad Koshak, and Michael Heinrich
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Pharmacology ,Traditional medicine ,biology ,business.industry ,lcsh:RM1-950 ,Nigella sativa ,Airway inflammation ,Pharmaceutical Science ,Asthma symptoms ,Bioinformatics ,medicine.disease ,Immunoglobulin E ,Black seed ,respiratory tract diseases ,IgE - Immunoglobulin E ,03 medical and health sciences ,lcsh:Therapeutics. Pharmacology ,0302 clinical medicine ,030228 respiratory system ,030220 oncology & carcinogenesis ,medicine ,biology.protein ,business ,Asthma - Abstract
Nigella sativa L. (NS) seeds, known as black seed, is a spice and a traditional herbal medicine used in various diseases including bronchial asthma. This review aimed to assess the studies supporting the medicinal use of NS in asthma and to highlight future research priorities. Various medical databases were searched for the effects of NS and its active secondary metabolites in asthma inflammation and outcomes. There were fourteen preclinical studies describing multiple effects of NS in animal or cellular models of asthma including bronchodilation, anti-histaminic, anti-inflammatory, anti-leukotrienes and immunomodulatory effects. Furthermore, seven clinical studies showed improvements in different asthma outcomes including symptoms, pulmonary function and laboratory parameters. However, often these studies are small and used ill-defined preparations. In conclusion, NS could be therapeutically beneficial in alleviating airway inflammation and the control of asthma symptoms, but the evidence remains scanty and is often based on poorly characterised preparations. Accordingly, well-designed large clinical studies using chemically well characterised NS preparation are required. Keywords: Nigella sativa, Black seed, Asthma, Traditional medicine, Clinical studies
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- 2017
4. Avocado as an emerging trigger for food protein–induced enterocolitis syndrome
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Pooja Varshney, Sheeba Cherian, and Kathryn Neupert
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Male ,Pulmonary and Respiratory Medicine ,Immunology ,MEDLINE ,03 medical and health sciences ,0302 clinical medicine ,Food allergy ,030225 pediatrics ,medicine ,Humans ,Immunology and Allergy ,Retrospective Studies ,Skin Tests ,Enterocolitis ,Persea ,business.industry ,Infant ,Immunoglobulin E ,medicine.disease ,IgE - Immunoglobulin E ,Food protein-induced enterocolitis syndrome ,030228 respiratory system ,Child, Preschool ,Female ,business ,Food Hypersensitivity - Published
- 2018
5. Pediatric food allergy-related household costs are influenced by age, but not disease severity☆
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Evalill Nilsson, Jennifer L.P. Protudjer, Hay Mar Wai, Victoria Thörnqvist, Jennie Strömquist, Staffan Ahlstedt, Lennart Nilsson, Natalia Ballardini, and Roelinde Middelveld
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lcsh:Immunologic diseases. Allergy ,Pulmonary and Respiratory Medicine ,Immunology ,OTCD, Over-the-Counter Drugs ,Immunoglobulin E ,Adolescents ,Article ,03 medical and health sciences ,0302 clinical medicine ,Disease severity ,Food allergy ,Environmental health ,Immunology and Allergy ,Medicine ,Epinephrine autoinjector ,EAI, Epinephrine Autoinjector ,030223 otorhinolaryngology ,Children ,Household ,USA, United States of America ,Over the counter drugs ,biology ,business.industry ,Public Health, Global Health, Social Medicine and Epidemiology ,medicine.disease ,Costs ,IgE - Immunoglobulin E ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,IgE, Immunoglobulin E ,030228 respiratory system ,biology.protein ,Intangible costs ,lcsh:RC581-607 ,business ,USD, American dollars ,Anaphylaxis ,Eco-Q, Food Allergy Economic Questionnaire - Abstract
Objective: The economic burden of food allergy on households is poorly understood. We evaluated the household costs associated with specialist-diagnosed pediatric food allergy, with focus on age and disease severity. Study design: A cross-sectional study of 70 Swedish case-control pairs (59% boys) was conducted using Food Allergy Economic questionnaire. Household costs were analyzed between age- and gender-matched cases (children aged 0-17 years, with specialist-diagnosed food allergy) and controls (non-food allergic households). Results: Parents were predominantly university-educated and employed full-time. Most cases had parent-reported previous anaphylaxis. Mean total annual household costs were comparable between cases and controls. However, compared to controls, cases had significantly higher direct medical-, and non-medical related costs; higher indirect medical-related costs, and higher intangible costs (all p amp;lt; 0.05). In a sensitivity analyses of only cases aged 0-12 years, direct household costs, including lost earnings due to childs hospitalization, were significantly higher than controls. Results from only children with severe disease paralleled those of all cases vs. controls. Conclusions: Although pediatric food allergy is not associated with higher total annual household costs, these households have significantly higher direct medical-related, indirect and intangible costs vs. non-food allergic households. Higher household costs were identified amongst younger children, but not disease severity. Funding Agencies|Swedish Asthma and Allergy Foundation [F2015-0004, F2015-0042]
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- 2019
6. Trimellitic anhydride induces low-grade mast cell degranulation without specific IgE
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Masafumi Sakashita, Tetsuji Takabayashi, Norihiko Narita, Masafumi Kanno, Kazuhiro Ogi, Takechiyo Yamada, and Shigeharu Fujieda
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0301 basic medicine ,Health, Toxicology and Mutagenesis ,TMA, trimellitic anhydride ,HMW, high molecular weight ,Toxicology ,Immunoglobulin E ,Article ,LMW, low molecular weight ,Mast cell ,OR, occupational rhinitis ,03 medical and health sciences ,Trimellitic anhydride ,chemistry.chemical_compound ,lcsh:RA1190-1270 ,immune system diseases ,PD, piecemeal degranulation ,hemic and lymphatic diseases ,medicine ,Occupational rhinitis ,neoplasms ,IgE, immunoglobulin E ,lcsh:Toxicology. Poisons ,IgE, immediate immunoglobulin E ,OA, occupational asthma ,biology ,Degranulation ,Respiratory Hypersensitivity ,food and beverages ,DNP, dinitrophenylated ,medicine.disease ,IL, interleukin ,IgE - Immunoglobulin E ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Respiratory hypersensitivity ,Immunology ,biology.protein ,BSA, bovine serum albumin ,Occupational asthma - Abstract
Objectives: Low-molecular-weight (LMW) substances are known to be causative agents of occupational asthma (OA) and occupational rhinitis (OR). Although most LMW substances are irritants or allergens, some can cause immediate type immunoglobulin E (IgE)-mediated allergic reactions. Trimellitic anhydride (TMA) is one such LMW substance, which is known as an immunological sensitizer. However, the exact molecular biological details of the effects of TMA remain unclear. Methods: We measured the β-hexosaminidase release from mast cells after directly exposing the cells to various LMW substances. The tyrosine phosphorylation of whole cellular molecules and the phosphorylation of extracellular signal-regulated kinase (ERK) were assessed by immunoblot assay. Results: Among the LMW substances tested, only TMA induced β-hexosaminidase release. However, the mast cell degranulation induced by TMA was lower than that induced by an antigen or a calcium ionophore. Moreover, the pattern of tyrosine phosphorylation of whole cellular molecules was quite different between IgE-mediated antigen stimulation and TMA exposure. The TMA effect on mast cells was independent of not only IgE but also Ca2+ influx. ERK phosphorylation was not detected in mast cells exposed to TMA. Conclusions: TMA induced mild degranulation of mast cells without IgE, even though the phosphorylation of ERK was not detected. This reaction suggests that TMA affects humans even upon first exposure. Therefore, it is imperative to avoid human exposure to high concentrations of TMA. In order to stop the development of severe asthma in individuals with OR, we need to be able to identify cases of OR caused by TMA as soon as possible. Keywords: Occupational rhinitis, Respiratory hypersensitivity, Trimellitic anhydride, Mast cell
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- 2016
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7. Subcutaneous allergen immunotherapy may be a suitable treatment for exacerbator allergic asthma
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Marie Hayat, Jocelyne Just, Flore Amat, Lucile Sesé, and M. Bourgoin-Heck
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Pulmonary and Respiratory Medicine ,Male ,Allergen immunotherapy ,Adolescent ,Dermatophagoides pteronyssinus ,Immunology ,Infusions, Subcutaneous ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,FVC - Forced vital capacity ,Hypersensitivity ,Immunology and Allergy ,Medicine ,Animals ,Humans ,Antigens, Dermatophagoides ,Child ,Retrospective Studies ,business.industry ,Allergic asthma ,Asthma ,IgE - Immunoglobulin E ,030228 respiratory system ,Desensitization, Immunologic ,Disease Progression ,Female ,France ,business - Published
- 2018
8. Airborne Microbial Allergens: Impact and Risk Assessment
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William R. Solomon
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Moisture ,biology ,Ecology ,Health, Toxicology and Mutagenesis ,Microorganism ,Public Health, Environmental and Occupational Health ,030204 cardiovascular system & hematology ,Toxicology ,biology.organism_classification ,Predation ,IgE - Immunoglobulin E ,03 medical and health sciences ,0302 clinical medicine ,Environmental chemistry ,030212 general & internal medicine ,Bacteria - Abstract
Despite their evolution in more natural niches, a variety of microorganisms have also successfully colonized man-made interiors. Such adaptable agents require fairly simple carbon and nitrogen sources, in limited amounts, and find these on surfaces and in fluid collections. Available moisture is also a critical permissive factor. Survival and growth indoors are fostered by the presence of stored biogenic materials and by soiling of surfaces with organic films derived from foodstuffs, soaps, volatile hydrocarbons and organic dusts. Commonly, predators such as protozoa, mites, insects and nematodes graze on a variety of established early invaders so that complex mixed populations are common. At the least, bacteria, fungi and their extracellular products regularly coexist on even marginal substrates.
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- 1990
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