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The article discusses the real-world use of Lenacapavir, a capsid inhibitor, in combination with an optimized background regimen for people with HIV-1. Lenacapavir has shown high levels of viral suppression in clinical trials, with over 80% of participants achieving undetectable plasma HIV-RNA. A retrospective observational study in France aims to describe the real-world use of Lenacapavir in various patient profiles and determine the continuation of treatment at weeks 26 and 52. The study is conducted in multiple centers and involves multidisciplinary committees to validate prescriptions. [Extracted from the article]

Researchers at the University of Texas Southwestern Medical Center have reported a rare case of Inflammatory Pseudotumor-like Extranodal Classic Hodgkin Lymphoma in an Acquired Immunodeficiency Syndrome (AIDS) patient with disseminated leishmaniasis. The patient presented with a small bowel mass that led to bowel perforation, highlighting the importance of identifying secondary CHL in HIV/AIDS patients with immunodeficiency and opportunistic infections. The study emphasizes the need for awareness of this rare condition, accurate diagnosis through special stains and cultures, and successful clinical management with antimicrobial therapy. This research has been peer-reviewed and published in the Journal of Gastrointestinal Oncology. [Extracted from the article]

The University of Tennessee Health Science Center conducted a study on ocular manifestations and treatment of monkeypox virus in two males with acquired immunodeficiency syndrome (AIDS). The cases highlighted the importance of early recognition, involvement of ophthalmology, and a multidisciplinary approach to prevent vision-threatening complications. Treatment involved antiviral medications tecovirimat and ganciclovir based on limited data and CDC recommendations. [Extracted from the article]

Researchers at Islamic Azad University in Iran conducted a study on Veno-Occlusive Disease with Immunodeficiency Syndrome (VODI), a rare genetic disorder with immune system irregularities and high mortality rates. The study focused on identifying SP110 mutations to improve diagnosis and treatment of VODI syndrome. Through whole-exome sequencing, a novel deletion-insertion mutation within the SP110 gene was discovered, potentially impacting the functionality of the SP110 protein. This research aims to enhance the understanding and diagnosis of VODI syndrome by creating a comprehensive panel for identifying mutations associated with the SP110 gene. [Extracted from the article]

A new report from Capital Medical University discusses the application of extended care in antiviral therapy for elderly patients with acquired immunodeficiency syndrome (AIDS). The study involved 200 elderly patients who received initial antiviral therapy and were randomly divided into a control group and a test group. After one year of follow-up, the test group receiving extended care showed higher medication compliance, increased CD4+ T lymphocyte count, undetectable viral load, and higher scores in quality of life domains compared to the control group. The research concludes that extended care is beneficial in improving medication compliance, antiviral effect, and quality of life for elderly AIDS patients. [Extracted from the article]

Researchers at Taipei City Hospital in Taiwan have reported new data on HIV/AIDS and its association with Cryptosporidium-induced acute kidney injury. Cryptosporidium is a pathogen that can cause infectious enteritis, particularly in immunocompromised patients. The researchers highlight the importance of early diagnosis of Cryptosporidium infection to prevent complications, and they present a unique case of cryptosporidiosis in a 33-year-old male patient with acute kidney injury and electrolyte imbalance. The patient's symptoms improved and he fully recovered from kidney injury and electrolyte imbalance after initiating antiretroviral therapy for HIV. This research has been peer-reviewed and published in The American Journal of the Medical Sciences. [Extracted from the article]

A report from Taipei City Hospital in Taiwan discusses a unique case of cryptosporidiosis in a 33-year-old male patient with acquired immunodeficiency syndrome (AIDS). The patient experienced acute kidney injury and electrolyte imbalances, which are uncommon manifestations of cryptosporidiosis. However, after receiving antiretroviral therapy for HIV, the patient's symptoms improved and he fully recovered from kidney injury and electrolyte imbalance. Early diagnosis and treatment with antiretroviral therapy were found to be crucial in this case. This research has been peer-reviewed and published in The American Journal of the Medical Sciences. [Extracted from the article]

A new study published in IDCases discusses a rare case of hemophagocytic lymphohistiocytosis (HLH) secondary to Talaromyces marneffei infection in a patient with acquired immunodeficiency syndrome (AIDS) and Alpha-thalassemia. Talaromyces marneffei is an opportunistic infection commonly found in immunosuppressed individuals, particularly those with AIDS. The patient, a 30-year-old with recurrent high fever and progressive cytopenia, achieved sustained remission after treatment with antifungals and glucocorticoids. This case highlights the importance of recognizing and treating rare complications in immunosuppressed populations. [Extracted from the article]

A new report from the Reproductive Health Promotion Research Center discusses the impact of mindfulness counseling on the sexual self-efficacy of women with HIV. The study involved 62 HIV-positive women who received eight weeks of counseling based on mindfulness, while a control group received no intervention. The results showed that the counseling significantly improved all dimensions of sexual self-efficacy in the intervention group, including readiness for sexual relationship, sexual self-stimulation, intimacy without sexual intercourse, and orgasm. The researchers recommend this method of counseling for HIV-positive women. [Extracted from the article]

A new study conducted by Hallym University in South Korea examines the knowledge and attitudes towards HIV/AIDS among women in Myanmar. The study, based on data collected from the 2015-2016 Myanmar Demographic Health Survey, reveals that while 91.6% of respondents were aware of AIDS, less than 60% possessed accurate knowledge of HIV transmission. The study identifies variations in knowledge and attitudes based on factors such as age, region, education, wealth, and media exposure. The findings highlight the need for tailored public health interventions to address the knowledge gap among women in different settings in Myanmar. However, it is important to note that the data collected is from 2015-2016, and ongoing research is necessary to capture the evolving landscape of HIV/AIDS awareness. [Extracted from the article]

A new study conducted by researchers at the University of Sharjah in the United Arab Emirates examined the levels of knowledge about HIV/AIDS among followers of different religions in India. The study analyzed data from the 2015-2016 Demographic and Health Survey and found that Sikh men had the highest level of knowledge about HIV/AIDS compared to followers of other religions. Conversely, Muslims and Hindus had the lowest levels of knowledge. The study suggests that public health strategies should be tailored to different religious groups in order to reduce the incidence of HIV/AIDS. [Extracted from the article]

A recent report from Tianjin First Central Hospital in China discusses the importance of diagnostic imaging in the early diagnosis and treatment of acquired immunodeficiency syndrome (AIDS)-related cerebral toxoplasmosis. The researchers emphasize the need for standardized imaging techniques and a thorough understanding of the radiological features of this condition. They developed a consensus paper to guide clinical decision-making and improve patient outcomes. The report highlights the lack of consensus on diagnostic imaging for AIDS-related cerebral toxoplasmosis and aims to provide guidance for healthcare professionals. [Extracted from the article]

A recent study conducted by the National University of Singapore examined the global prevalence and factors related to intimate partner violence (IPV) among people living with HIV/AIDS (PLWHA). The study found that four in ten PLWHA have experienced some form of IPV in their lifetime, with emotional IPV being the most prevalent. Rates of physical and any types of IPV varied depending on the measurement used and the study design. The researchers concluded that more cross-national research is needed to obtain a more reliable estimate of IPV prevalence. Public health measures are crucial in preventing and addressing IPV among PLWHA. [Extracted from the article]

A recent study conducted in Gujarat, India, examined the spectrum of splenic lesions in patients with HIV/AIDS. The study analyzed spleen specimens obtained from 257 patients over a 29-year period. The most common pathology identified was tuberculosis, followed by cryptococcosis, malarial infection, and cytomegalovirus infection. Other findings included chronic passive venous congestion, perivascular fibrosis, hemosiderosis, and amyloidosis. The study provides valuable insights into the splenic lesions observed in AIDS patients in India, highlighting the wide range of differentials such as tuberculosis, opportunistic infections, and lymphoma. [Extracted from the article]

This document provides information about a pilot study that aims to evaluate the feasibility and safety of using cytomegalovirus-specific, anti-HIV chimeric antigen receptor (CMV-HIV CAR) T cells as a potential immunotherapy for people living with HIV. The study focuses on the use of CAR T cells engineered to target HIV-infected cells, with the goal of eliminating these cells. The researchers propose using autologous CMV-specific T cells, which can be stimulated by endogenous CMV, to address the issue of low persistence of CAR T cells. The study is in its early stages and aims to assess the presence and effectiveness of CMV/HIV-CAR T cells in healthy individuals living with HIV. [Extracted from the article]

This document provides information about a Phase 2 clinical trial (NCT06238635) evaluating the effectiveness of dostarlimab and cobolimab in treating metastatic or recurrent cervical cancer. The trial is non-randomized and open-label, with two cohorts of participants: one who is immunotherapy naive and one who has been previously exposed to immunotherapy. The primary outcome measures include objective response rate, progression-free survival, overall survival, immune-related progression-free survival, and adverse events. The trial is expected to enroll 66 participants and follow them for up to 7 years. It is funded by GlaxoSmithKline and being conducted by Beth Israel Deaconess Medical Center in collaboration with GlaxoSmithKline. The document also outlines the eligibility criteria for participation, including restrictions on live vaccination, use of herbal medications, and prior organ transplantation. Pregnant and breastfeeding women are excluded from the study. Administrative information, such as contact details and data sharing plans, is also provided. [Extracted from the article]

A patent application has been published online for a method and system developed by Chun-Hsuan Ho to detect immune efficacy and treat cancer. The current methods for evaluating immune efficacy are limited, so Ho's method involves classifying T cells and natural killer cells based on specific antigens and comparing the percentages of these cell subgroups to reference ranges. The system includes a processor and memory to implement these steps and generate an immune efficacy report. This invention aims to provide a tool for evaluating immune function and potentially guiding cancer treatment. [Extracted from the article]

A recent report from Creighton University discusses the case of a 25-year-old man who presented with an enlarging soft tissue mass in his forearm, which was later diagnosed as botryomycosis. Botryomycosis is a rare bacterial infection that predominantly affects immunocompromised patients and can mimic sarcoma. The patient also had an undiagnosed case of acquired immunodeficiency syndrome (AIDS), which unfortunately led to his death. The report highlights the importance of considering infection as a potential cause of mass-like lesions in immunocompromised individuals. [Extracted from the article]

A recent study conducted at Mahidol University in Bangkok, Thailand investigated the effectiveness of bortezomib (BTZ) for treating adult-onset immunodeficiency (AOID) syndrome with anti-interferon-gamma autoantibodies (anti-IFN-g-auto-Abs). The study involved five patients who received BTZ followed by oral cyclophosphamide. The primary outcomes measured were the difference in antibody levels at 8 and 48 weeks compared to baseline, as well as the incidence of serious adverse events (AEs). The study found that BTZ treatment did not significantly decrease antibody levels and 10 opportunistic infections (OIs) were observed during the treatment period. The researchers suggest that combining rituximab with BTZ may be necessary to prevent the generation of new autoantibody-producing plasma cells. [Extracted from the article]

A study conducted by researchers at the University of Pennsylvania describes a case of severe occlusive vasculitis that led to a diagnosis of AIDS in a previously healthy middle-aged man. The patient presented with sudden vision loss in his left eye and was found to have retinal vascular disease and ophthalmic artery occlusion. Further medical workup revealed HIV positivity, and the ocular findings were attributed to an associated occlusive vasculitis. The study suggests that testing for HIV should be considered in cases of occlusive retinal vasculitis, as it is a rare cause of such findings. [Extracted from the article]

A recent study conducted at the Instituto de Infectologia Emilio Ribas in Brazil aimed to describe the prevalence and main features of progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in people living with HIV/AIDS. The study found that the prevalence of PML-IRIS was 11.8%, with most patients experiencing unmasking PML-IRIS. In-hospital mortality and morbidity were high, but one-year survival rates were similar to those reported in high-income countries. The study provides valuable insights into the understanding and management of PML-IRIS in low- and middle-income countries. [Extracted from the article]

A recent study conducted by researchers at Army Medical University in Chongqing, China, has provided new insights into spinal cord injury-induced immunodeficiency syndrome (SCI-IDS). The study suggests that SCI-IDS is associated with the exaggerated activation of sympathetic preganglionic neurons (SPNs) and the occurrence of abnormally high levels of spinal sympathetic reflexes (SSR), known as sympathetic hyperreflexia. As the post-injury survival time lengthens, there is an increase in SSR excitability, resulting in an excess sympathetic output that disrupts the immune response. The researchers propose strategies to reverse sympathetic hyperreflexia and improve the overall quality of life for individuals with SCI. [Extracted from the article]

Keywords: Acquired Immunodeficiency Syndrome; Diagnostics and Screening; HIV/AIDS; Health and Medicine; Hospitals; Immune System Diseases and Conditions; Immunodeficiency Syndrome; Lentivirus Infections; Primate Lentiviruses; RNA Viruses; Retroviridae; Slow Virus Diseases and Conditions; Vertebrate Viruses; Viral; Viral Sexually Transmitted Diseases and Conditions; Virology EN Acquired Immunodeficiency Syndrome Diagnostics and Screening HIV/AIDS Health and Medicine Hospitals Immune System Diseases and Conditions Immunodeficiency Syndrome Lentivirus Infections Primate Lentiviruses RNA Viruses Retroviridae Slow Virus Diseases and Conditions Vertebrate Viruses Viral Viral Sexually Transmitted Diseases and Conditions Virology 78 78 1 11/06/23 20231106 NES 231106 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on HIV/AIDS have been published. Acquired Immunodeficiency Syndrome, Diagnostics and Screening, HIV/AIDS, Health and Medicine, Hospitals, Immune System Diseases and Conditions, Immunodeficiency Syndrome, Primate Lentiviruses, RNA Viruses, Retroviridae, Slow Virus Diseases and Conditions, Vertebrate Viruses, Viral, Viral Sexually Transmitted Diseases and Conditions, Virology, Lentivirus Infections. [Extracted from the article]

All the patients underwent postoperative visual acuity of better than 6/24.: In emergency cases cataract surgery in HIV patients is generally safe, regardless of CD4 count, but their general and ocular health should be optimized preoperatively." Acquired Immunodeficiency Syndrome, Cataract Surgery, HIV/AIDS, Health and Medicine, Immune System Diseases and Conditions, Lentivirus Infections, Immunodeficiency Syndrome, RNA Viruses, Refractive Surgical Procedures, Slow Virus Diseases and Conditions, Surgery, Viral Sexually Transmitted Diseases and Conditions Keywords: Acquired Immunodeficiency Syndrome; Cataract Surgery; HIV/AIDS; Health and Medicine; Immune System Diseases and Conditions; Immunodeficiency Syndrome; Lentivirus Infections; RNA Viruses; Refractive Surgical Procedures; Slow Virus Diseases and Conditions; Surgery; Viral Sexually Transmitted Diseases and Conditions EN Acquired Immunodeficiency Syndrome Cataract Surgery HIV/AIDS Health and Medicine Immune System Diseases and Conditions Immunodeficiency Syndrome Lentivirus Infections RNA Viruses Refractive Surgical Procedures Slow Virus Diseases and Conditions Surgery Viral Sexually Transmitted Diseases and Conditions 88 88 1 10/16/23 20231016 NES 231016 2023 OCT 16 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on HIV/AIDS. [Extracted from the article]

Keywords: Acquired Immunodeficiency Syndrome; Cancer; Epidemiology; HIV/AIDS; Health and Medicine; Herpesvirus; Immune System Diseases and Conditions; Immunodeficiency Syndrome; Kaposi Sarcoma; Lentivirus Infections; Oncology; RNA Viruses; Sarcomas; Skin Diseases and Conditions; Slow Virus Diseases and Conditions EN Acquired Immunodeficiency Syndrome Cancer Epidemiology HIV/AIDS Health and Medicine Herpesvirus Immune System Diseases and Conditions Immunodeficiency Syndrome Kaposi Sarcoma Lentivirus Infections Oncology RNA Viruses Sarcomas Skin Diseases and Conditions Slow Virus Diseases and Conditions 54 54 1 07/24/23 20230724 NES 230724 2023 JUL 24 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Data detailed on HIV/AIDS have been presented. Acquired Immunodeficiency Syndrome, Cancer, Epidemiology, HIV/AIDS, Health and Medicine, Herpesvirus, Immune System Diseases and Conditions, Kaposi Sarcoma, Lentivirus Infections, Immunodeficiency Syndrome, Oncology, RNA Viruses, Sarcomas, Skin Diseases and Conditions, Slow Virus Diseases and Conditions. [Extracted from the article]