Search

Your search keyword '"Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP]"' showing total 14 results
Start Over Author "Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP]"
14 results on '"Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP]"'

1. Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine

Author

Françoise Lunel, Adeline Pivert, Frédéric Le Gal, Alexandra Ducancelle, Paul Calès, Wael Y. Mansour, Pierre Abgueguen, Emmanuel Gordien, Hélène Le Guillou-Guillemette, Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service des maladies infectieuses et tropicales [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
Male, HBsAg, Hepatitis D, Chronic, [SDV]Life Sciences [q-bio], Organophosphonates, Interferon alpha-2, Antibodies, Viral, Emtricitabine, Antiviral Agents, Deoxycytidine, Polyethylene Glycols, 03 medical and health sciences, 0302 clinical medicine, Tenofovir disoproxil fumarate, Pegylated interferon, Virology, Humans, Medicine, Tenofovir, Chronic hepatitis Delta, 030304 developmental biology, Hepatitis, 0303 health sciences, business.industry, Adenine, Seroconversion anti-HBs, Interferon-alpha, virus diseases, Middle Aged, Hepatitis B, medicine.disease, Hepatitis D, Recombinant Proteins, 3. Good health, Treatment Outcome, Infectious Diseases, HBeAg, DNA, Viral, RNA, Viral, Drug Therapy, Combination, 030211 gastroenterology & hepatology, Hepatitis Delta Virus, business, Viral load, medicine.drug
Abstract

International audience; BackgroundHepatitis Delta virus (HDV) Infection has a worldwide distribution, with approximately 20 millions infected persons. Interferon (IFN) is the only approved drug for the treatment of HDV infection which is still a difficult to treat disease. Objectives To report a successful treatment of a patient with a chronic severe hepatitis Delta using combination therapy with Pegylated interferon (PegIFN), Tenofovir disoproxil fumarate (TDF) and Emtricitabine (FTC). Study Design The patient, a 47 years -old male patient, originating from Dagestan (East Asia), suffered of chronic hepatitis Delta infection. The patient was HBsAg, HBeAg, and anti-Delta Ab (IgG) positive. Serum HBV-DNA level was elevated (more than 9 logUI/mL). Serum HDV-RNA level was up to 5.6 log (copies/ml). Genotypes HBV/D and HDV-1 were demonstrated. The liver histology revealed chronic active hepatitis (Metavir score: A2F2). The treatment was started with PegIFN (180 μg/week) for two months and then TDF (300 mg/day) (combined later with FTC) was added. Results Sustained response was obtained after 10 months of treatment and was accompanied by the clearance of serum hepatitis B virus surface antigen with seroconversion to anti-HBs. Conclusion This case report suggests that Delta infection may co-exist with high replicative HBV infection and that combination therapy with PegIFN and nucleoside/tide analogues seems to be more effective than IFN alone. Given that only a single case is reported, further studies including more patients are warranted.

Published
2010

2. Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: a cross sectional study

Author

Mohamed Aye, Ségolène Brichler, Abdellahi Ould Amar, Françoise Lunel-Fabiani, Michel Rosenheim, F Zahra Fall Malick, Alexandra Ducancelle, Emmanuel Gordien, Pascal Veillon, Frédéric Le Gal, Wael Y. Mansour, Lô Baïdy, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor

Subjects
Microbiology (medical), Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, FIBROMETER, Adolescent, Cross-sectional study, viruses, [SDV]Life Sciences [q-bio], medicine.disease_cause, Gastroenterology, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Humans, Hepatitis Antibodies, hepatitis Delta virus, 030304 developmental biology, Aged, Hepatitis B virus, 0303 health sciences, Analysis of Variance, business.industry, Coinfection, Mauritania, virus diseases, Hepatitis B, Middle Aged, medicine.disease, Hepatitis D, 3. Good health, Infectious Diseases, Cross-Sectional Studies, Immunology, 030211 gastroenterology & hepatology, Female, business, hepatitis B virus
Abstract

International audience; OBJECTIVES: Mauritania is a highly endemic region for hepatitis B (HBV) and delta (HDV) viruses. No data are available on HDV's impact on the severity of liver disease in consecutive HBV-infected patients in Africa. This study evaluated the degree of liver fibrosis in a cohort of chronic HBV carriers.METHODS: Three-hundred consecutive HBV-infected Mauritanian patients were checked for HDV infection via the detection of anti-HDV antibodies (Ab) and viral RNA. HBV- vs. HBV/HDV-infected patients were compared by physical examination, biological analyses, and the APRI (aspartate aminotransferase to platelet ratio index) and FibroMeter tests for determination of liver fibrosis.RESULTS: More than 30% of the patients had anti-HDVAb. Among these, 62.2% were HDV-RNA positive. Co-infected patients were older (>8-years) than HBV-mono-infected patients. They had more liver tests abnormalities and clinical or ultrasound signs of liver fibrosis. APRI and FibroMeter scores were also significantly increased in these patients. In multivariate analysis, beyond HDVAb, male gender and HBV-VL >3.7logIU/mL were the only markers linked to significant liver fibrosis.CONCLUSIONS: In Mauritania, HDV co-infection worsens liver disease, both clinically and biologically, as confirmed by the APRI and FibroMeter tests. These tests may be useful for the management of delta hepatitis, which is a major health problem in Mauritania.

Published
2013

3. Virological and epidemiological features of hepatitis delta infection among blood donors in Nouakchott, Mauritania

Author

Mohamed-Abdellahi Bollahi, Alexandra Ducancelle, Ségolène Brichler, Françoise Lunel, Michel Rosenheim, Wael Y. Mansour, Emmanuel Gordien, Frédéric Le Gal, Baidy Lô, Cheikh-Tijani Hamed, Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service de bactériologie-Virologie-Hygiène [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université des Sciences de Technologie et de Médecine (USTM), Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP]

Subjects
Adult, Male, HBsAg, medicine.medical_specialty, Cirrhosis, Adolescent, Epidemiology, [SDV]Life Sciences [q-bio], viruses, Blood Donors, Virus, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, HDV, Virology, Genotype, HBV, HDV genotypes, Medicine, Humans, 030212 general & internal medicine, Hepatitis Antibodies, Phylogeny, Hepatitis B Surface Antigens, biology, business.industry, Transmission (medicine), Mauritania, virus diseases, biochemical phenomena, metabolism, and nutrition, medicine.disease, Hepatitis B, Hepatitis D, 3. Good health, Infectious Diseases, Hepatocellular carcinoma, Carrier State, Multivariate Analysis, biology.protein, 030211 gastroenterology & hepatology, Female, Antibody, Hepatitis Delta Virus, business
Abstract

International audience; BackgroundIn Mauritania, some authors have described a possible high prevalence of hepatitis delta virus (HDV) infection in the 1990s in studies of small-size samples. Objectives The aims of our study were to assess the prevalence of HDV in HBsAg positive blood donors in Mauritania, to identify the main risk factors for HDV transmission and to analyze genetic diversity of HDV strains. Study design From October 2008 to December 2009, 11,100 consecutive blood donors were considered in this study. Among them, 1700 (15.3%) were HBsAg positive and 455 accepted to participate in this study. Demographic, epidemiological, ethnical, clinical and biological data were recorded. HDV screening, i.e., antibodies (HDVAb) and RNA (HDV-RNA) detection, was performed for all of them as well as HDV and HBV genotyping. Results Ninety/455 (19.78%) donors were HDVAb positive and HDV-RNA was detectable in 56 (62.2%) of them. HDV infection was significantly associated with older age, number of marriages, military profession, residence in the desert and a history of hospitalization. The HDV genotypes of the circulating strains were HDV-1 (89.3%) and HDV-5 (10.7%). Conclusion HDV is highly endemic in Mauritanian blood donors indicating that a high number of them will develop chronic hepatitis, cirrhosis or hepatocellular carcinoma. Associated risk factors support nosocomial transmission of HDV. These data underline the need to reinforce HBV vaccination in newborns and in blood donors without HBV markers, together with screening for HDV in HBV-infected individuals.

Published
2012

4. Prevalence, risk factors, and molecular epidemiology of hepatitis B and hepatitis delta virus in pregnant women and in patients in Mauritania

Author

Mariama Abdou Chekaraou, Françoise Lunel-Fabiani, Wael Mansour, Ahmad Sidiya, Elkhalil Ishagh, Baidy Lo, Alexandra Ducancelle, Pascal Veillon, Frédéric Le Gal, Emmanuel Gordien, Ségolène Brichler, F Zahra Fall Malick, Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service de bactériologie-Virologie-Hygiène [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université des Sciences de Technologie et de Médecine (USTM), Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP]

Subjects
Adult, Male, HBsAg, medicine.medical_specialty, Blood transfusion, Adolescent, Genotype, Epidemiology, medicine.medical_treatment, viruses, [SDV]Life Sciences [q-bio], medicine.disease_cause, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, genotypes, Virology, Prevalence, Humans, Medicine, hepatitis Delta virus, Pregnancy Complications, Infectious, Young adult, Aged, 030304 developmental biology, Hepatitis B virus, Molecular Epidemiology, 0303 health sciences, Molecular epidemiology, business.industry, Mauritania, virus diseases, Middle Aged, Hepatitis B, medicine.disease, Hepatitis D, digestive system diseases, 3. Good health, Infectious Diseases, Female, 030211 gastroenterology & hepatology, business, Viral load, hepatitis B virus
Abstract

No recent data are available on hepatitis B virus (HBV) and hepatitis Delta virus (HDV) prevalence in Mauritania. One thousand twenty pregnant women and 946 patients visiting for routine checkups were screened for HBV and HDV infection. Demographic, epidemiological, ethnic, clinical, and biological data were recorded. HBV and HDV genotypes were determined by sequencing and phylogenetic analyses. In the pregnant women and patients cohorts, respectively, the prevalence of HBsAg (10.7% and 18.3%) and anti-HBcAb (66.3% and 76.5%) indicated high HBV endemicity. In pregnant women, exposure to HBV was significantly associated in multivariate analysis with education level, ethnicity, blood transfusion, and occupation. HDV antibodies (HDVAb) were found in 14.7% of pregnant women. In patients, HBsAg was found less frequently in females than in males. Again in multivariate analysis, exposure to HBV was significantly correlated with gender (males), and HDVAb positivity with age and gender. The HBV DNA viral load was >3 log IU/ml in only 10.1% of pregnant women and in 17.3% of patients. HDV-RNA was detectable in 21 (67.7%) of the 31 patients positive for HDVAb, and in 11 of the 16 pregnant women positive for HDVAb (68.8%). The most frequent HBV genotypes were: HBV/D, 53%; HBV/E, 35%; and HBV/A, 12%. Sub-genotyping revealed HBV/D1,/D7, and the recently described/D8. HDV genotypes were: HDV-1, 90.3% and HDV-5, 9.7%. This study confirms the high prevalence of HBV and HDV infections in Mauritania and demonstrates the high genetic diversity of HBV in this country. J. Med. Virol. 84: 1186–1198, 2012. © 2012 Wiley Periodicals, Inc.

Published
2012

5. Resolution of Chronic Hepatitis Delta after one year of combined therapy with Pegylated Interferon, Tenofovir and Emtricitabine

Author

Mansour, Wael, Ducancelle, Alexandra, Le Gal, Frédéric, Pivert, Adeline, Le Guillou-Guillemette, Hélène, Calès, Paul, Gordien, Emmanuel, Lunel-Fabiani, Françoise, Univ Angers, Okina, Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 03/2009

Published
2009

6. Epidémiologie moléculaire de l’infection par les virus de l'hépatite B (VHB) et de l'hépatite Delta (VHD) en Mauritanie

Author

Mansour, Wael, Ishagh, Elkhalil, Veillon, Pascal, Le Gal, Frédéric, Lô, Baidy, Aye, Mohamed, Gordien, Emmanuel, Lunel-Fabiani, Françoise, Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Université des Sciences de Technologie et de Médecine (USTM), Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, and Univ Angers, Okina

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 10/2009

Published
2009

7. Epidémiologie moléculaire de l’infection par les virus de l'hépatite B (VHB) et de l'hépatite Delta (VHD) en Mauritanie

Author

Mansour, Wael, Abdou-Chekaraou, M., Ishagh, Elkhalil, Veillon, Pascal, Le Gal, Frédéric, Lô, Baidy, Aye, Mohamed, Gordien, Emmanuel, Lunel-Fabiani, Françoise, Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Université des Sciences de Technologie et de Médecine (USTM), Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, and Univ Angers, Okina

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 12/2009

Published
2009

8. Evaluation d'une technique d'extraction et d'amplification de l'ARN viral Delta à partir des taches de sang et de sérums séchés sur papiers buvards

Author

Mansour, Wael, Hamed, Cheikh-Tijani, Ahmed-Tijani, E., Amadou-Mody, S., Le Gal, Frédéric, Gordien, Emmanuel, Ducancelle, Alexandra, Bollahi, Mohamed-Abdellahi, Lunel-Fabiani, Françoise, Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Univ Angers, Okina, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 12/2009

Published
2009

9. New virologic tools for management of chronic hepatitis B and C

Author

Christophe Rodriguez, Stéphane Chevaliez, Jean-Michel Pawlotsky, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
HBsAg, Transcription-mediated amplification, Hepacivirus, medicine.disease_cause, Polyethylene Glycols, 0302 clinical medicine, real-time TMA, Clinical Trials as Topic, 0303 health sciences, Gastroenterology, Hepatitis C, Hepatitis B, antigen quantification, Recombinant Proteins, 3. Good health, Treatment Outcome, HBeAg, RNA, Viral, Drug Therapy, Combination, 030211 gastroenterology & hepatology, Oligopeptides, Hepatitis B virus, Proline, Point-of-Care Systems, Hepatitis C virus, Genome, Viral, Biology, Real-Time Polymerase Chain Reaction, Antiviral Agents, Drug Administration Schedule, Article, Virus, 03 medical and health sciences, Hepatitis B, Chronic, diagnostic assay, Ribavirin, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, 030304 developmental biology, Hepatology, Interferon-alpha, Sequence Analysis, DNA, Hepatitis C, Chronic, medicine.disease, Virology, point-of-care tests, DNA, Viral, Immunology, next-generation sequencing, Hepatitis C Antigens, real-time PCR
Abstract

International audience; Molecular biology techniques are routinely used to diagnose and monitor treatment of patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These tools can detect and quantify viral genomes and analyze their sequence to determine their genotype or subtype and to identify nucleotide or amino acid substitutions associated with resistance to antiviral drugs. They include real-time target amplification methods, which have been standardized and are widely used in clinical practice to diagnose and monitor HBV and HCV infections, and next-generation sequencing techniques, which are still restricted to research laboratories. In addition, new enzyme immunoassays can quantify hepatitis B surface and hepatitis C core antigens, and point-of-care tests and alternatives to biologic tests that require whole-blood samples obtained by venipuncture have been developed. We review these new virologic methods and their clinical and research applications to HBV and HCV infections.

Published
2012

10. New virologic tools for management of chronic hepatitis B and C

Author

Chevaliez, Stéphane, Rodriguez, Christophe, Pawlotsky, Jean-Michel, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
diagnostic assay, point-of-care tests, real-time TMA, next-generation sequencing, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, real-time PCR, antigen quantification
Abstract

International audience; Molecular biology techniques are routinely used to diagnose and monitor treatment of patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These tools can detect and quantify viral genomes and analyze their sequence to determine their genotype or subtype and to identify nucleotide or amino acid substitutions associated with resistance to antiviral drugs. They include real-time target amplification methods, which have been standardized and are widely used in clinical practice to diagnose and monitor HBV and HCV infections, and next-generation sequencing techniques, which are still restricted to research laboratories. In addition, new enzyme immunoassays can quantify hepatitis B surface and hepatitis C core antigens, and point-of-care tests and alternatives to biologic tests that require whole-blood samples obtained by venipuncture have been developed. We review these new virologic methods and their clinical and research applications to HBV and HCV infections.

Published
2012

11. New virologic tools for management of chronic hepatitis B and C

Author

Chevaliez, Stéphane, Rodriguez, Christophe, Pawlotsky, Jean-Michel, Guellaen, Georges, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre national de référence des virus des hépatites B, C et Delta, Université Paris 13 (UP13)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe hospitalier Henri-Mondor

Subjects
diagnostic assay, point-of-care tests, real-time TMA, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, next-generation sequencing, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, real-time PCR, antigen quantification
Abstract

International audience; Molecular biology techniques are routinely used to diagnose and monitor treatment of patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These tools can detect and quantify viral genomes and analyze their sequence to determine their genotype or subtype and to identify nucleotide or amino acid substitutions associated with resistance to antiviral drugs. They include real-time target amplification methods, which have been standardized and are widely used in clinical practice to diagnose and monitor HBV and HCV infections, and next-generation sequencing techniques, which are still restricted to research laboratories. In addition, new enzyme immunoassays can quantify hepatitis B surface and hepatitis C core antigens, and point-of-care tests and alternatives to biologic tests that require whole-blood samples obtained by venipuncture have been developed. We review these new virologic methods and their clinical and research applications to HBV and HCV infections.

Published
2012

12. Impact of co infection with B+Delta viruses on liver fibrosis measured by transient elastography or FibroMeter

Author

Lunel-Fabiani, Françoise, Mansour, Wael, Causse, Xavier, Le Gal, Frédéric, Gordien, Emmanuel, Fouchard-Hubert, Isabelle, Si Ahmed, Si Nafa, de Fontevraud, Groupe, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Service d’Hépato-Gastro-Entérologie [Orléans], Centre Hospitalier Régional d'Orléans (CHRO), Hopital d'Orleans, and Univ Angers, Okina

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 03/2009

Published
2009

13. Impact of B+Delta viruses co infection on the liver stiffness measurement (LSM) by transient elastography

Author

Si Ahmed, Si Nafa, Mansour, Wael, Causse, Xavier, Le Gal, Frédéric, Gordien, Emmanuel, Fouchard-Hubert, Isabelle, Lunel-Fabiani, Françoise, de Fontevraud, Groupe, Hopital d'Orleans, Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service d’Hépato-Gastro-Entérologie [Orléans], Centre Hospitalier Régional d'Orléans (CHRO), and Univ Angers, Okina

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 04/2008

Published
2008

14. Impact de l'Hépatite Delta sur la fibrose hépatique mesurée par élastométrie impulsionnelle

Author

Si Ahmed, Si Nafa, Mansour, Wael, Causse, Xavier, Fouchard-Hubert, Isabelle, Lunel-Fabiani, Françoise, de Fontevraud, Groupe, Hopital d'Orleans, Centre national de référence des virus des hépatites B, C et Delta, Institut National de la Transfusion Sanguine [Paris] (INTS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Groupe hospitalier Henri-Mondor, Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Service d’Hépato-Gastro-Entérologie [Orléans], Centre Hospitalier Régional d'Orléans (CHRO), and Univ Angers, Okina

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

Date du colloque: 10/2008

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results