1. Two Cases of Primary Sclerosing Cholangitis Overlapping with Autoimmune Hepatitis in Adults
- Author
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Hiroshi Kijima, Shinsaku Fukuda, Tetsu Endo, Kenichiro Mikami, Tetsuro Yoshimura, Go Igarashi, Akira Kurose, Juichi Sakamoto, Naoya Sawada, Ryu Satake, and Rie Ohta
- Subjects
Male ,medicine.medical_specialty ,endocrine system diseases ,Combination therapy ,Biopsy ,Cholangitis, Sclerosing ,Case Report ,Autoimmune hepatitis ,digestive system ,Gastroenterology ,Primary sclerosing cholangitis ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Glucocorticoids ,Pathological ,immunosuppression ,autoimmune hepatitis ,medicine.diagnostic_test ,business.industry ,Ursodeoxycholic Acid ,digestive, oral, and skin physiology ,primary sclerosing cholangitis ,Overlap syndrome ,Syndrome ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,Ursodeoxycholic acid ,Hepatitis, Autoimmune ,Liver ,International Autoimmune Hepatitis Group scoring system ,030220 oncology & carcinogenesis ,Liver biopsy ,Immunology ,Endoscopic retrograde cholangiography ,Drug Therapy, Combination ,030211 gastroenterology & hepatology ,Tomography, X-Ray Computed ,business ,Cholangiography ,medicine.drug - Abstract
Overlap syndrome between primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) is extremely rare in Japan. We herein report two adult patients with PSC-AIH overlap syndrome. They were diagnosed with PSC-AIH overlap syndrome based on the findings of endoscopic retrograde cholangiography and liver biopsy, and using the International Autoimmune Hepatitis Group scoring system. In both cases, PSC preceded AIH, and combination therapy with steroid and ursodeoxycholic acid was effective. Because there are few reported cases in Japan, it is important to study more cases to shed light on the clinical and pathological features of PSC-AIH overlap syndrome.
- Published
- 2017