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Your search keyword '"Irmiger, Heather M."' showing total 7 results
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7 results on '"Irmiger, Heather M."'

1. Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise

Author

Van Guilder, Gary P., Hoetzer, Greta L., Smith, Derek T., Irmiger, Heather M., Greiner, Jared J., Stauffer, Brian L., and DeSouza, Christopher A.

Subjects
Obesity in adolescence -- Care and treatment, Obesity in adolescence -- Research, Endothelium -- Research, Fibrinolysis -- Research, Biological sciences
Abstract

Endothelial release of tissue-type plasminogen activator (t-PA) regulates fibrinolysis and is considered to be a primary endogenous defense mechanism against thrombosis. Adiposity is associated with an increased risk of atherothrombotic events. We determined the influence of overweight and obesity on the capacity of the vascular endothelium to release t-PA and the effects of regular aerobic exercise on endothelial t-PA release in previously sedentary overweight and obese adults. First, we studied 66 sedentary adults: 28 normal-weight (BMI endothelium; fibrinolysis; tissue-type plasminogen activator

Published
2005

3. Estrogen receptor-[alpha] thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women

Author

Hoetzer, Greta L., Irmiger, Heather M., Stauffer, Brian L., and DeSouza, Christopher A.

Subjects
Estrogen -- Genetic aspects, Estrogen -- Physiological aspects, Thymidine -- Genetic aspects, Thymidine -- Physiological aspects, Adenine -- Genetic aspects, Adenine -- Physiological aspects, Endothelium -- Genetic aspects, Endothelium -- Physiological aspects, Postmenopausal women -- Genetic aspects, Postmenopausal women -- Physiological aspects, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2005.01.028 Byline: Greta L. Hoetzer (a), Heather M. Irmiger (a), Brian L. Stauffer (a)(b), Christopher A. DeSouza (a)(c) Abstract: We hypothesized that the capacity of the endothelium to release tissue-type plasminogen activator is blunted in postmenopausal women with long (TA).sub.n repeat alleles ([greater than or equal to]18 repeats). Author Affiliation: (a) Department of Integrative Physiology, Integrative Vascular Biology Laboratory, University of Colorado, Boulder, CO (b) Department of Medicine, Divisions of Cardiology (c) Geriatrics, University of Colorado, Health Sciences Center, Denver, CO Article History: Received 27 September 2004; Revised 19 November 2004; Accepted 11 January 2005 Article Note: (footnote) Supported by National Institutes of Health awards HL68030 and DK62061 and American Heart Association award 0255921Z.

Published
2005

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