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3 results on '"Ivan H. Lee"'

1. Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

Author

Anne E. Mohan, Aaron S. Cote, Eric Khong, Keith A. Mattern, Michael Whittington, Kevin M. Maloney, Eric B. Sirota, Yee Swan Ang, Michael DiBenedetto, Anthony Diaz-Santana, Richard Desmond, Ivan H. Lee, Beata Tao, Muhammad Sofian Bin Asi Sihombing, Christopher Pridgen, Glenn Spencer, Hsieh Yao D. Chang, Kevin M. Sirk, Hong Ren, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, and Cuixian Yang

Subjects
Active ingredient, Phase map, 010405 organic chemistry, business.industry, Chemistry, Scientific method, Organic Chemistry, Physical and Theoretical Chemistry, 010402 general chemistry, Process engineering, business, 01 natural sciences, 0104 chemical sciences
Abstract

The final chemical transformation and isolation in the synthesis of an active pharmaceutical ingredient (API), referred to as the Pure Step, is often chemically simple but scientifically, operation...

Published
2021
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2. Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process

Author

Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, and Hong Ren

Subjects
body regions, 010405 organic chemistry, Scientific method, Sustainable manufacturing, Organic Chemistry, Business, Physical and Theoretical Chemistry, 010402 general chemistry, Pulp and paper industry, 01 natural sciences, Salt formation, 0104 chemical sciences
Abstract

The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...

Published
2020
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3. Use of Lecithin As an Antistatic Agent in Nonconductive Crystallization Slurries for Isolating Pure Active Pharmaceutical Ingredients

Author

Ivan H. Lee

Subjects
Active ingredient, food.ingredient, Chromatography, Materials science, education, Organic Chemistry, food and beverages, Lecithin, law.invention, food, Safety risk, law, Antistatic agent, Slurry, Physical and Theoretical Chemistry, Crystallization, health care economics and organizations
Abstract

Static buildup in glass-lined processing train during pure API crystallizations in organic solvents can result in costly glass damage to the vessel internals, and presents a potential safety risk o...

Published
2013
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