688 results on '"J, Just"'
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2. A melt-electrowritten filter for capture and culture of circulating colon cancer cells
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M.L. Jørgensen, C. Müller, M. Sikkersoq, M. Nadzieja, Z. Zhang, Y. Su, J. Just, K.-L. Garm Spindler, and M. Chen
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Circulating tumor cells ,Melt electrospinning writing ,On-site culture ,Polycaprolactone ,Bioconjugation ,Colorectal cancer ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Metastasis is the major cause of death in cancer patients accounting for about 90% of the mortality. The detection and analysis of the hallmark of metastasis, circulating tumor cells (CTCs), have significant impact in cancer biology and clinical practice. However, the scarcity of CTCs in blood, particularly in that of colorectal cancer patients, is a serious bottleneck in the development of CTC-based precision medicine. Herein, the melt electrowriting (MEW) technology was used for reproductive fabrication of a biocompatible antibody-presenting polycaprolactone filter with tailored porous structure. It is demonstrated, for the first time, that such filter can be used not only to catch cancer cells spiked in whole blood but also to culture the cancer cells directly on site. Specifically, HT29 colon cancer cells can be captured with an efficiency of 85%, and when spiked into 4 mL of whole blood, 47% were captured on one Ø12mm filter. Furthermore, repeated capture and culture experiments have shown that as few as 20 HT29 colon cancer cells spiked into 4 mL of whole blood can be captured on the filter and within 2 weeks be expanded on site to become tumor bodies that are visible to the untrained eye. This filter allows for downstream analysis, such as flow cytometry, immunocytochemistry, Western blotting, and rt-qPCR. This technology represents a simple and cost-effective platform that potentially enables fast and efficient culture of rare CTCs from patients’ blood. This provides non-invasive alternatives for solid biopsy tumor materials for treatment screening, with great potential to realize precision medicine for cancer treatment.
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- 2020
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3. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
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J. Bousquet, S. Arnavielhe, A. Bedbrook, M. Bewick, D. Laune, E. Mathieu-Dupas, R. Murray, G. L. Onorato, J. L. Pépin, R. Picard, F. Portejoie, E. Costa, J. Fonseca, O. Lourenço, M. Morais-Almeida, A. Todo-Bom, A. A. Cruz, J. da Silva, F. S. Serpa, M. Illario, E. Menditto, L. Cecchi, R. Monti, L. Napoli, M. T. Ventura, G. De Feo, D. Larenas-Linnemann, M. Fuentes Perez, Y. R. Huerta Villabolos, D. Rivero-Yeverino, E. Rodriguez-Zagal, F. Amat, I. Annesi-Maesano, I. Bosse, P. Demoly, P. Devillier, J. F. Fontaine, J. Just, T. P. Kuna, B. Samolinski, A. Valiulis, R. Emuzyte, V. Kvedariene, D. Ryan, A. Sheikh, P. Schmidt-Grendelmeier, L. Klimek, O. Pfaar, K. C. Bergmann, R. Mösges, T. Zuberbier, R. E. Roller-Wirnsberger, P. Tomazic, W. J. Fokkens, N. H. Chavannes, S. Reitsma, J. M. Anto, V. Cardona, T. Dedeu, J. Mullol, T. Haahtela, J. Salimäki, S. Toppila-Salmi, E. Valovirta, B. Gemicioğlu, A. Yorgancioglu, N. Papadopoulos, E. P. Prokopakis, S. Bosnic-Anticevich, R. O’Hehir, J. C. Ivancevich, H. Neffen, E. Zernotti, I. Kull, E. Melen, M. Wickman, C. Bachert, P. Hellings, S. Palkonen, C. Bindslev-Jensen, E. Eller, S. Waserman, M. Sova, G. De Vries, M. van Eerd, I. Agache, T. Casale, M. Dykewickz, R. N. Naclerio, Y. Okamoto, D. V. Wallace, and MASK study group
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App ,ARIA ,Asthma ,Care pathways ,MASK ,mHealth ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.
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- 2018
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4. CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report
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J. Bousquet, G. L. Onorato, C. Bachert, M. Barbolini, A. Bedbrook, L. Bjermer, J. Correia de Sousa, N. H. Chavannes, A. A. Cruz, E. De Manuel Keenoy, P. Devillier, J. Fonseca, S. Hun, T. Kostka, P. W. Hellings, M. Illario, J. C. Ivancevich, D. Larenas-Linnemann, J. Millot-Keurinck, D. Ryan, B. Samolinski, A. Sheikh, A. Yorgancioglu, I. Agache, S. Arnavielhe, M. Bewick, I. Annesi-Maesano, J. M. Anto, K. C. Bergmann, C. Bindslev-Jensen, S. Bosnic-Anticevich, J. Bouchard, D. P. Caimmi, P. Camargos, G. W. Canonica, V. Cardona, A. M. Carriazo, C. Cingi, E. Colgan, A. Custovic, R. Dahl, P. Demoly, G. De Vries, W. J. Fokkens, J. F. Fontaine, B. Gemicioğlu, N. Guldemond, Z. Gutter, T. Haahtela, B. Hellqvist-Dahl, E. Jares, G. Joos, J. Just, N. Khaltaev, T. Keil, L. Klimek, M. L. Kowalski, I. Kull, P. Kuna, V. Kvedariene, D. Laune, R. Louis, A. Magnan, J. Malva, E. Mathieu-Dupas, E. Melén, E. Menditto, M. Morais-Almeida, R. Mösges, J. Mullol, R. Murray, H. Neffen, R. O’Hehir, S. Palkonen, N. G. Papadopoulos, G. Passalacqua, J. L. Pépin, F. Portejoie, D. Price, B. Pugin, F. Raciborski, F. E. R. Simons, M. Sova, O. Spranger, C. Stellato, A. Todo Bom, P. V. Tomazic, M. Triggiani, A. Valero, E. Valovirta, O. VandenPlas, A. Valiulis, M. van Eerd, M. T. Ventura, M. Wickman, I. Young, T. Zuberbier, A. Zurkuhlen, and A. Senn
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Rhinitis ,Asthma ,CHRODIS ,ARIA ,MASK ,Sunfrail ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Reference Sites Network for Prevention and Care of Frailty and Chronic Conditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the 28 items of JA-CHRODIS. A short summary was proposed for each item and 18 experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28 items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CHRODIS recommendations for the evaluation of Good Practices.
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- 2017
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5. The environmental and evolutionary history of Lake Ohrid (FYROM/Albania): interim results from the SCOPSCO deep drilling project
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B. Wagner, T. Wilke, A. Francke, C. Albrecht, H. Baumgarten, A. Bertini, N. Combourieu-Nebout, A. Cvetkoska, M. D'Addabbo, T. H. Donders, K. Föller, B. Giaccio, A. Grazhdani, T. Hauffe, J. Holtvoeth, S. Joannin, E. Jovanovska, J. Just, K. Kouli, A. Koutsodendris, S. Krastel, J. H. Lacey, N. Leicher, M. J. Leng, Z. Levkov, K. Lindhorst, A. Masi, A. M. Mercuri, S. Nomade, N. Nowaczyk, K. Panagiotopoulos, O. Peyron, J. M. Reed, E. Regattieri, L. Sadori, L. Sagnotti, B. Stelbrink, R. Sulpizio, S. Tofilovska, P. Torri, H. Vogel, T. Wagner, F. Wagner-Cremer, G. A. Wolff, T. Wonik, G. Zanchetta, and X. S. Zhang
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project. The four main aims of the project are to infer (i) the age and origin of Lake Ohrid (Former Yugoslav Republic of Macedonia/Republic of Albania), (ii) its regional seismotectonic history, (iii) volcanic activity and climate change in the central northern Mediterranean region, and (iv) the influence of major geological events on the evolution of its endemic species. The Ohrid basin formed by transtension during the Miocene, opened during the Pliocene and Pleistocene, and the lake established de novo in the still relatively narrow valley between 1.9 and 1.3 Ma. The lake history is recorded in a 584 m long sediment sequence, which was recovered within the framework of the International Continental Scientific Drilling Program (ICDP) from the central part (DEEP site) of the lake in spring 2013. To date, 54 tephra and cryptotephra horizons have been found in the upper 460 m of this sequence. Tephrochronology and tuning biogeochemical proxy data to orbital parameters revealed that the upper 247.8 m represent the last 637 kyr. The multi-proxy data set covering these 637 kyr indicates long-term variability. Some proxies show a change from generally cooler and wetter to drier and warmer glacial and interglacial periods around 300 ka. Short-term environmental change caused, for example, by tephra deposition or the climatic impact of millennial-scale Dansgaard–Oeschger and Heinrich events are superimposed on the long-term trends. Evolutionary studies on the extant fauna indicate that Lake Ohrid was not a refugial area for regional freshwater animals. This differs from the surrounding catchment, where the mountainous setting with relatively high water availability provided a refuge for temperate and montane trees during the relatively cold and dry glacial periods. Although Lake Ohrid experienced significant environmental change over the last 637 kyr, preliminary molecular data from extant microgastropod species do not indicate significant changes in diversification rate during this period. The reasons for this constant rate remain largely unknown, but a possible lack of environmentally induced extinction events in Lake Ohrid and/or the high resilience of the ecosystems may have played a role.
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- 2017
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6. Urticaire chronique et allergie : rationnel pour une exploration ciblée
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H Chabane, J Vitte, C Dzviga, C Lambert, A Sarrat, S Lefevre, G Dalampira, E Seve, C Klingebiel, P Nicaise-Roland, C Palussière, J Bienvenu, R Couderc, P Demoly, and J Just
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Immunology and Allergy - Published
- 2022
7. Environmental control on the occurrence of high-coercivity magnetic minerals and formation of iron sulfides in a 640 ka sediment sequence from Lake Ohrid (Balkans)
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J. Just, N. R. Nowaczyk, L. Sagnotti, A. Francke, H. Vogel, J. H. Lacey, and B. Wagner
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
The bulk magnetic mineral record from Lake Ohrid, spanning the past 637 kyr, reflects large-scale shifts in hydrological conditions, and, superimposed, a strong signal of environmental conditions on glacial–interglacial and millennial timescales. A shift in the formation of early diagenetic ferrimagnetic iron sulfides to siderites is observed around 320 ka. This change is probably associated with variable availability of sulfide in the pore water. We propose that sulfate concentrations were significantly higher before ∼ 320 ka, due to either a higher sulfate flux or lower dilution of lake sulfate due to a smaller water volume. Diagenetic iron minerals appear more abundant during glacials, which are generally characterized by higher Fe / Ca ratios in the sediments. While in the lower part of the core the ferrimagnetic sulfide signal overprints the primary detrital magnetic signal, the upper part of the core is dominated by variable proportions of high- to low-coercivity iron oxides. Glacial sediments are characterized by high concentration of high-coercivity magnetic minerals (hematite, goethite), which relate to enhanced erosion of soils that had formed during preceding interglacials. Superimposed on the glacial–interglacial behavior are millennial-scale oscillations in the magnetic mineral composition that parallel variations in summer insolation. Like the processes on glacial–interglacial timescales, low summer insolation and a retreat in vegetation resulted in enhanced erosion of soil material. Our study highlights that rock-magnetic studies, in concert with geochemical and sedimentological investigations, provide a multi-level contribution to environmental reconstructions, since the magnetic properties can mirror both environmental conditions on land and intra-lake processes.
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- 2016
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8. Sedimentological processes and environmental variability at Lake Ohrid (Macedonia, Albania) between 637 ka and the present
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A. Francke, B. Wagner, J. Just, N. Leicher, R. Gromig, H. Baumgarten, H. Vogel, J. H. Lacey, L. Sadori, T. Wonik, M. J. Leng, G. Zanchetta, R. Sulpizio, and B. Giaccio
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
Lake Ohrid (Macedonia, Albania) is thought to be more than 1.2 million years old and host more than 300 endemic species. As a target of the International Continental scientific Drilling Program (ICDP), a successful deep drilling campaign was carried out within the scope of the Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO) project in 2013. Here, we present lithological, sedimentological, and (bio-)geochemical data from the upper 247.8 m composite depth of the overall 569 m long DEEP site sediment succession from the central part of the lake. According to an age model, which is based on 11 tephra layers (first-order tie points) and on tuning of bio-geochemical proxy data to orbital parameters (second-order tie points), the analyzed sediment sequence covers the last 637 kyr. The DEEP site sediment succession consists of hemipelagic sediments, which are interspersed by several tephra layers and infrequent, thin (< 5 cm) mass wasting deposits. The hemipelagic sediments can be classified into three different lithotypes. Lithotype 1 and 2 deposits comprise calcareous and slightly calcareous silty clay and are predominantly attributed to interglacial periods with high primary productivity in the lake during summer and reduced mixing during winter. The data suggest that high ion and nutrient concentrations in the lake water promoted calcite precipitation and diatom growth in the epilimnion during MIS15, 13, and 5. Following a strong primary productivity, highest interglacial temperatures can be reported for marine isotope stages (MIS) 11 and 5, whereas MIS15, 13, 9, and 7 were comparably cooler. Lithotype 3 deposits consist of clastic, silty clayey material and predominantly represent glacial periods with low primary productivity during summer and longer and intensified mixing during winter. The data imply that the most severe glacial conditions at Lake Ohrid persisted during MIS16, 12, 10, and 6, whereas somewhat warmer temperatures can be inferred for MIS14, 8, 4, and 2. Interglacial-like conditions occurred during parts of MIS14 and 8.
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- 2016
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9. Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 2 : allergie respiratoire
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H. Chabane, C. Metz-Favre, C. Klingebiel, C. Mailhol, F. Le Pabic, C. Castelain, C. Palussière, B. Uring-Lambert, C. Bouz, G. Dalampira, A. Sarrat, E. Seve, S. Lefevre, C. Dzviga, P. Nicaise-Roland, C. Lambert, J. Bienvenu, R. Couderc, P. Demoly, and J. Just
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Immunology and Allergy - Published
- 2021
10. Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 5 : allergie aux piqûres et morsures d’arthropodes et autres allergies ou pathologies
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Joana Vitte, C. Dzviga, C. Palussière, C. Lambert, S. Lefevre, Rémy Couderc, Pascal Demoly, P. Nicaise-Roland, J. Just, C. Klingebiel, A. Sarrat, G. Dalampira, Jacques Bienvenu, E. Seve, and H. Chabane
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy - Abstract
Resume Les examens biologiques d’allergie contribuent de facon significative au diagnostic et au suivi des allergies aux piqures et morsures d’arthropodes. Les dosages d’IgE specifiques apportent la preuve d’un mecanisme allergique IgE-dependant. L’utilisation rationnelle des outils biologiques disponibles selon les donnees actualisees de la science est a meme de garantir l’efficience diagnostique. Le mesusage de la biologie de l’allergie et/ou leur interpretation erronee risque d’aboutir a des attitudes therapeutiques inadaptees. Consciente de cet enjeu, la Societe francaise d’allergologie (SFA) a mis en place un groupe de travail multidisciplinaire pour l’actualisation des recommandations de biologie de l’allergie, les precedentes recommandations elaborees en 2005 par la Haute autorite de sante (HAS) etant devenues en partie obsoletes en raison de l’evolution des techniques et concepts. La methodologie utilisee est celle des recommandations pour la pratique clinique (RPC) elaboree par la HAS, meme si le texte n’a pas ete labellise par celle institution. Le groupe de travail a redige 8 recommandations gradees sur l’allergie aux piqures et morsures d’arthropodes et 5 recommandations gradees sur d’autres pathologies immuno-allergiques ou frontiere. Bien que non exhaustives, ces 13 questions repondent aux preoccupations les plus courantes des prescripteurs qu’ils soient allergologues ou non, tout en tenant compte du contexte reglementaire francais.
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- 2021
11. Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 3 : allergie alimentaire
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H. Chabane, G. Dalampira, C. Klingebiel, S. Lefevre, C. Palussière, P. Nicaise-Roland, C. Metz-Favre, M. Bouvier, A. Sarrat, E. Seve, C. Delebarre-Sauvage, C. Dzviga, J. Bienvenu, R. Couderc, P. Demoly, and J. Just
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Immunology and Allergy - Published
- 2021
12. Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 4 : allergie aux médicaments
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E. Seve, P. Nicaise-Roland, J. Just, C. Delebarre-Sauvage, C. Klingebiel, Pascal Demoly, S. Lefevre, Jacques Bienvenu, G. Dalampira, M. Bouvier, C. Dzviga, C. Palussière, A. Sarrat, H. Chabane, Carine Metz-Favre, and Rémy Couderc
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0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy - Abstract
Resume Contrairement aux allergies respiratoires, alimentaires et aux venins d’hymenopteres qui concernent des allergenes proteiques, la prise en charge des allergies aux medicaments necessite rarement le recours aux examens biologiques pour obtenir la preuve d’un mecanisme allergique IgE-dependant. Un nombre tres restreint de dosages d’IgE specifiques de medicaments est disponible car la grande majorite des medicaments sont des haptenes. L’utilisation rationnelle des outils biologiques disponibles selon les donnees actualisees de la science est a meme de garantir l’efficience diagnostique. Le mesusage de la biologie de l’allergie et/ou leur interpretation erronee risque d’aboutir a des attitudes therapeutiques inadaptees voire dangereuses. Consciente de cet enjeu, la Societe francaise d’allergologie (SFA) a mis en place un groupe de travail multidisciplinaire pour l’actualisation des recommandations de biologie de l’allergie, les precedentes recommandations elaborees en 2005 par la Haute autorite de sante (HAS) etant devenues en partie obsoletes en raison de l’evolution des techniques et concepts. La methodologie utilisee est celle des recommandations pour la pratique clinique (RPC) elaboree par la HAS, meme si le texte n’a pas ete labellise par celle institution. Le groupe de travail a redige 11 recommandations gradees sur l’allergie aux medicaments. Bien que non exhaustives, ces 11 questions repondent aux preoccupations les plus courantes des prescripteurs qu’ils soient allergologues ou non pour la prise en charge des patients ayant une suspicion d’allergie aux medicaments, tout en tenant compte du contexte reglementaire francais.
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- 2021
13. Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Texte court
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H. Chabane, C. Klingebiel, G. Dalampira, A. Sarrat, S. Lefevre, C. Dzviga, C. Metz-Favre, J. Vitte, P. Nicaise-Roland, E. Seve, C. Palussière, C. Lambert, P-A. Apoil, M. Bouvier, C. Castelain, F. Le Pabic, C. Delebarre-Sauvage, B. Uring-Lambert, L. Garnier, C. Mailhol, C. Bouz, J.C. Farouz, J. Bienvenu, R. Couderc, P. Demoly, and J. Just
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Immunology and Allergy - Published
- 2021
14. Depth distribution of secondary phases in kesterite Cu2ZnSnS4 by angle-resolved X-ray absorption spectroscopy
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J. Just, D. Lützenkirchen-Hecht, O. Müller, R. Frahm, and T. Unold
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Biotechnology ,TP248.13-248.65 ,Physics ,QC1-999 - Abstract
The depth distribution of secondary phases in the solar cell absorber material Cu2ZnSnS4 (CZTS) is quantitatively investigated using X-ray Absorption Near Edge Structure (XANES) analysis at the K-edge of sulfur at varying incidence angles. Varying information depths from several nanometers up to the full thickness is achieved. A quantitative profile of the phase distribution is obtained by a self-consistent fit of a multilayer model to the XANES spectra for different angles. Single step co-evaporated CZTS thin-films are found to exhibit zinc and copper sulfide secondary phases preferentially at the front or back interfaces of the film.
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- 2017
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15. Allergie au sésame : revue générale
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S. Saf, J. Just, G. Benoist, E. Bidat, S. Honjoya, and N. Cottel
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Immunology and Allergy - Abstract
Resume Le sesame est un allergene a connaitre car present dans notre alimentation mais aussi dans certains produits pharmaceutiques et cosmetiques. L’allergie au sesame a une prevalence faible mais est potentiellement severe avec un risque eleve d’anaphylaxie. Les tests cutanes et les IgE specifiques sont de valeur inconstante ; la place des allergenes recombinants reste a mieux preciser. Le test de provocation par voie orale tient une place essentielle en cas de doute diagnostique et pour evaluer une eventuelle guerison dont le taux est autour de 20 %. Il necessite une equipe rompue a la prise en charge de l’anaphylaxie. Un prick test superieur a 14 mm semble etre associe a un taux de positivite du TPO de l’ordre de 95 %. La prise en charge repose avant tout sur l’eviction du sesame. Une liste peut etre remise aux familles afin de notifier les principales sources d’exposition. L’immunotherapie orale pourrait apparaitre comme une perspective interessante mais doit etre actuellement reservee aux centres experts.
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- 2021
16. Organisation des structures de soins transversales en allergologie en France en 2020
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Frédéric Bérard, Martine Morisset, Philippe Bonniaud, E. Collet, S. Lefevre, J. Just, L. Collin, and F. de Blay
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030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy - Abstract
Resume Introduction Les allergies touchent 25 % de la population generale avec une augmentation des allergies severes. Le developpement en France de structures de soins transversales en allergologie pour une prise en charge pluridisciplinaire des patients repond a un besoin de sante publique. Notre travail a pour but de faire un etat des lieux de ces structures. Methodes Enquete descriptive par questionnaire envoye aux chefs de services de structures de soins soit avec une activite principale en allergologie, soit avec une activite variee en allergologie. L’enquete portait sur l’organisation administrative, les equipes medicales et paramedicales, l’offre de soins et les moyens techniques des structures. Resultats Trente-sept structures ont pu etre analysees dont 27 avec une activite principale en allergologie et 10 avec une activite variee en allergologie. Pour les premieres, le nombre de medecins varie de 1 a 16 et les equivalents temps pleins infirmier de 0,8 a 5,9. Les nombres d’hospitalisations de jour et de consultations annuelles sont respectivement de 1049 (220 a 3275) et 3561 (609 a 13 674). Un tiers du recrutement des patients est hors departement. Toutes les structures avec une activite principale en allergologie realisent des explorations sur les allergies alimentaires, medicamenteuses et aux pneumallergenes mais seulement 81 % et 74 % assurent respectivement la prise en charge des allergies aux hymenopteres et des eczemas de contact. Conclusions Cette etude constitue un premier etat des lieux des structures hospitalieres transversales en allergologie en France afin de permettre de guider le developpement d’Unites transversales d’allergologie.
- Published
- 2021
17. Characterization of particulate organic matter in the Lena River delta and adjacent nearshore zone, NE Siberia – Part 2: Lignin-derived phenol compositions
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M. Winterfeld, M. A. Goñi, J. Just, J. Hefter, and G. Mollenhauer
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Ecology ,QH540-549.5 ,Life ,QH501-531 ,Geology ,QE1-996.5 - Abstract
The Lena River in central Siberia is one of the major pathways translocating terrestrial organic matter (OM) from its vast catchment area to the coastal zone of the Laptev Sea and the Arctic Ocean. The permafrost soils of its far south-stretching catchment, which store huge amounts of OM, will most likely respond differently to climate warming and remobilize previously frozen OM with distinct properties specific for the source vegetation and soil. To characterize the material discharged by the Lena River, we analyzed the lignin phenol composition in total suspended matter (TSM) from surface water collected in spring and summer, surface sediments from Buor Khaya Bay along with soils from the Lena Delta's first (Holocene) and third terraces (Pleistocene ice complex), and plant samples. Our results show that lignin-derived cinnamyl : vanillyl (C / V) and syringyl : vanillyl (S / V) ratios are > 0.14 and 0.25, respectively, in TSM and surface sediments, whereas in delta soils they are > 0.16 and > 0.51, respectively. These lignin compositions are consistent with significant inputs of organic matter from non-woody angiosperm sources mixed with organic matter derived from woody gymnosperm sources. We applied a simple linear mixing model based on the C / V and S / V ratios, and the results indicate the organic matter in delta TSM samples and Buor Khaya Bay surface sediments contain comparable contributions from gymnosperm material, which is primarily derived from the taiga forests south of the delta, and angiosperm material typical for tundra vegetation. Considering the small catchment area covered by tundra (~ 12%), the input is substantial and tundra-derived OM input is likely to increase in a warming Arctic. The similar and high acid to aldehyde ratios of vanillyl and syringyl (Ad / AlV, S) in Lena Delta summer TSM (> 0.7 and > 0.5, respectively) and Buor Khaya Bay surface sediments (> 1.0 and > 0.9, respectively) suggest that the OM is highly degraded and Lena River summer TSM could be a possible source of the surface sediments. The Ad / AlV, S ratios of the first and third delta terraces were generally lower (mean ratios > 0.4 and > 0.4, respectively) than summer TSM and surface sediments. This implies that TSM contains additional contributions from a more degraded OM source (southern catchment and/or finer more degraded particle size). Alternatively, OM degradation on land after permafrost thawing and subaqueously during transport and sedimentation could be considerable. Despite the high natural heterogeneity of OM stored in delta soils and exported by the Lena River, the catchment-characteristic vegetation is reflected by the lignin biomarker composition. Climate-warming-related changes in the Lena River catchment may be detectable in changing lignin biomarker composition and diagenetic alteration.
- Published
- 2015
- Full Text
- View/download PDF
18. Les phénotypes de l’asthme chez l’enfant et l’adolescent
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J. Just
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy ,030212 general & internal medicine - Abstract
Resume L’heterogeneite de l’asthme dans l’enfance est caracterisee par de multiples phenotypes lies a des mecanismes physiopathologiques differents qui caracterisent les endotypes. Les sensibilisations allergeniques multiples et precoces sont associees a un risque plus eleve d’exacerbations d’asthme. Le risque de persistance de l’asthme a l’âge adulte est un phenotype d’asthme severe notamment a debut precoce avec comorbiditees allergiques multiples et/ou avec mauvaise fonction respiratoire. A l’inverse, l’inflammation des voies respiratoires a neutrophile est moins frequente chez les enfants souffrant d’asthme et n’est pas stable au cours du temps.
- Published
- 2020
19. Recommendations for the prescription and interpretation of laboratory tests that can be used in the diagnosis or monitoring of allergies, available in France. Part 1: Preamble
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H. Chabane, J. Vitte, A. Sarrat, E. Seve, P.-A. Apoil, G. Dalampira, C. Palussière, C. Klingebiel, S. Lefevre, P. Nicaise-Roland, C. Dzviga, C. Lambert, C. Metz-Favre, M. Bouvier, C. Castelain, F. Le Pabic, C. Delebarre-Sauvage, B. Uring-Lambert, L. Garnier, C. Bouz, C. Mailhol, J.C. Farouz, J. Bienvenu, R. Couderc, P. Demoly, J. Just, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de l'Université de Bourgogne (LPUB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Synlab Provence, Laboratoire de psychologie de l'interaction et des relations intersubjectives (INTERPSY), Université de Lorraine (UL), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Laboratoire d'Immunologie 'Autoimmunité et Hypersensibilités' [AP-HP Hôpital Bichat, Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Strasbourg, Complexe de recherche interprofessionnel en aérothermochimie (CORIA), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Eurofins Biomnis
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[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Immunology and Allergy ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; Allergy laboratory tests make an important contribution to the diagnosis and monitoring of allergic diseases. The increase in the prevalence of these diseases in the French population in recent decades and the increasingly frequent use of biological diagnostics requires the optimisation of the use of this tool. Its rational use according to updated scientific data and an approach favoring the cost/benefit ratio can guarantee diagnostic efficiency. Aware of this issue, the French society of allergology (SFA) has set up a multidisciplinary task force to update allergy biology recommendations, the previous recommendations drawn up in 2005 by the High authority for health (HAS) having become partly obsolete due to the evolution of techniques and concepts. The methodology used is that of the recommendations for clinical practice (RPC) developed by the HAS, even if the text has not been labelled by that institution. The working group drafted 73 graded recommendations and a preamble with 6 general questions. Although not exhaustive, these 79 questions answer the most common concerns of prescribers whether they are allergists or not for the management of patients with allergies or with suspected allergies, while taking into account the French regulatory context.; Les examens biologiques d’allergie contribuent de façon importante au diagnostic et au suivi des maladies allergiques. L’augmentation de la prévalence de ces maladies dans la population française durant les dernières décennies et le recours de plus en plus fréquent au diagnostic biologique nécessite l’optimisation de l’utilisation de cet outil. Son utilisation rationnelle selon les données actualisées de la science et une démarche privilégiant le rapport coût/bénéfice sont à même de garantir l’efficience diagnostique. Consciente de cet enjeu, la Société française d’allergologie (SFA) a mis en place un groupe de travail multidisciplinaire pour l’actualisation des recommandations de biologie de l’allergie, les précédentes recommandations élaborées en 2005 par la Haute Autorité de santé (HAS) étant devenues en partie obsolètes en raison de l’évolution des techniques et concepts. La méthodologie utilisée est celle des recommandations pour la pratique clinique (RPC) élaborée par la HAS, même si le texte n’a pas été labellisé par celle institution. Le groupe de travail a rédigé 73 recommandations gradées et un préambule comportant 6 questions d’ordre général. Bien que non exhaustives, ces 79 questions répondent aux préoccupations les plus courantes des prescripteurs qu’ils soient allergologues ou non pour la prise en charge des patients allergiques ou ayant une suspicion d’allergie, tout en tenant compte du contexte réglementaire français.
- Published
- 2021
20. Punción pancreática ecodirigida: estudio multicéntrico Ultrasound-guided biopsy of the pancreas: A multicenter study
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M. C. Garre Sánchez, P. Rendón Unceta, A. López Cano, M. Gómez Rubio, B. de Cuenca Morón, J. M. Segura Cabral, M. Crespo Sánchez, L. A. Gil Grande, M. J. Varas Lorenzo, J. Just Timoneda, R. Gómez Rodríguez, J. Galcera Tomás, A. Abraldes Bechiarelli, M. Macías Rodríguez, A. Muñoz Benvenuty, M. Tejada Cabrera, A. Olveira, and E. Palacios Lázaro
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Punción-aspiración con aguja fina (PAAF) ,Lesiones ocupantes de espacio pancreáticas ,Tumor de páncreas ,Punción control ecográfico ,Fine-needle aspiration ,Pancreatic space-occupying lesions ,Pancreatic tumor ,Ultrasound guided biopsy ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Objetivo: en el seno de la Asociación de Ecografía Digestiva se decidió realizar un estudio retrospectivo multicéntrico sobre la punción-aspiración con aguja fina (PAAF) de lesiones ocupantes de espacio pancreáticas, mediante control ecográfico y por vía percutánea, con el objetivo de valorar el rendimiento de dicha técnica y poder compararla con la punción mediante ultrasonografía endoscópica. Participantes: en el estudio han participado 10 hospitales con 222 pacientes con lesiones pancreáticas entre 8 y 120 mm, sospechosas de malignidad. Resultados: el análisis de los resultados muestra una sensibilidad del 89%, especificidad 98%, valor predictivo positivo 99% y negativo 74%, con precisión diagnóstica global 91%. No encontramos ninguna complicación significativa. Conclusión: la PAAF de lesiones pancreáticas por vía percutánea es de alta rentabilidad diagnóstica y con pocas y leves complicaciones.Objective: members of "Asociación de Ecografía Digestiva" decided to carry out a multicenter retrospective study on fine-needle aspiration biopsy for pancreatic space-occupying lesions under ultrasonographic guidance and via the percutaneous route in order to assess this technique's performance versus endoscopic ultrasound-guided biopsy. Subjects: 10 hospitals for a total of 222 patients with suspiciously malignant, 8-120-mm pancreatic lesions were included in the study. Results: the analysis of results shows a sensitivity of 89%, a specificity of 98%, a positive predictive value of 99%, and a negative predictive value of 74%, for an overall diagnostic accuracy of 91%. No major complications occurred. Conclusion: percutaneous fine-needle aspiration for pancreatic lesions is highly cost-effective and has few and mild complications.
- Published
- 2007
21. Publisher Correction: Indo-Pacific Walker circulation drove Pleistocene African aridification
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H. J. L. van der Lubbe, I. R. Hall, S. Barker, S. R. Hemming, T. F. Baars, A. Starr, J. Just, B. C. Backeberg, and J. C. A. Joordens
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Multidisciplinary - Abstract
In this Article, a processing error led to the wrong versions of Fig. 3 and Extended Data Fig. 4 being published. Figure 3e did not include the entirety of the eastern Africa soil carbonate δ13C database as compiled by ref.13. Fig. 3 of the original Article has been corrected, and Fig. 1 of this Amendment shows the original and corrected Fig. 3 side by side, for transparency. In the Methods section of the original Article, there are further details about how this record has been produced. The last paragraph of the Methods has been corrected; the original text was: “On the basis of ref.13, time series of δ13C values from soil carbonate were combined for the Omo-Turkana Basin and the southern Kenyan-Tanzanian sites using their medians, and interquartile ranges using six-data-point bins.” Furthermore, the original version of Extended Data Fig. 4 did not display data from eastern African hominin site Afar; the figure and caption have been updated accordingly, and the original and corrected versions are shown as Fig. 2 to this Amendment. These changes do not alter any inferences drawn from the data. These errors have been corrected in the online version of the Article.
- Published
- 2022
22. Erratum à l’article « Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Texte court » [Rev. Fr. Allergol. 61 (7) (2021) 436–58]
- Author
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H. Chabane, C. Klingebiel, G. Dalampira, A. Sarrat, S. Lefevre, C. Dzviga, C. Metz-Favre, J. Vitte, P. Nicaise-Roland, E. Seve, C. Palussière, C. Lambert, P.-A. Apoil, M. Bouvier, C. Castelain, F. Le Pabic, C. Delebarre-Sauvage, B. Uring-Lambert, L. Garnier, C. Mailhol, C. Bouz, J.C. Farouz, J. Bienvenu, R. Couderc, P. Demoly, and J. Just
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Immunology and Allergy - Published
- 2022
23. Nouvelles recommandations françaises en biologie de l’allergie, synthèse
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C. Klingebiel, C. Bouz, Pascal Demoly, C. Castelain, G. Dalampira, J.C. Farouz, Joana Vitte, A. Sarrat, Jacques Bienvenu, P. Nicaise-Roland, C. Dzviga, B. Uring-Lambert, C. Mailhol, C. Palussière, S. Lefevre, M. Bouvier, P.A. Apoil, E. Seve, Lorna Garnier, J. Just, C. Lambert, Rémy Couderc, C. Delebarre-Sauvage, Carine Metz-Favre, F. Le Pabic, and H. Chabane
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030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy - Abstract
Resume L’evolution des connaissances, des techniques et la mise a disposition en routine d’un nombre important d’allergenes moleculaires, ainsi que les evolutions reglementaires qui ont fait disparaitre certains extraits allergeniques pour prick tests, ont eu des repercussions sur le diagnostic biologique de l’allergie. La ociete francaise d’allergologie a constitue un groupe de travail, dont l’objectif etait d’actualiser les recommandations de biologie de l’allergie initialement elaborees par la HAS 2 en 2005. La methodologie utilisee pour la redaction est celle de la « Recommandation de bonne pratique », selon la methode « Recommandation pour la pratique clinique » de la HAS. Elle a permis d’elaborer 73 recommandations gradees selon le niveau de preuves, destinees a tous les prescripteurs, dont les principales sont decrites ici.
- Published
- 2020
24. Les tests de provocation alimentaire dans 4 pays européens : France, Espagne, Italie et Royaume-Uni
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Antoine Deschildre, A. Santos, Pascal Demoly, F. Paravati, P. Rodriguez del Rio, Elena Carboni, J. Just, J. Litovsky, Davide Caimmi, E. Manca, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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0303 health sciences ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,[SDV]Life Sciences [q-bio] ,Immunology and Allergy ,3. Good health ,030304 developmental biology - Abstract
Resume En Europe, il y a une variabilite dans les modalites de realisation de tests de provocation aux aliments dans les differents centres d’allergologie. La Societe italienne d’allergologie et immunologie pediatrique (SIAIP) a mene une enquete, dans plusieurs pays, pour evaluer les pratiques locales de realisation de ces tests et rechercher les possibles differences. Nous presentons les resultats d’un questionnaire realise sur une plateforme en ligne par 120 centres d’allergologie, distribues en 4 pays europeens differents : France, Italie, Espagne, Royaume-Uni. Malgre quelques differences, les modalites de prise en charge des patients restent assez concordantes entre les differents pays.
- Published
- 2020
25. Suboptimal basophil activation by molecular allergens can lead to false-negative basophil activation test
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Y. Chantran, N. Cottel, G. Germain, S. Saf, A. Lemoine, N. Lambert, M. Bourgoin-Heck, J. Just, and S. Wanin
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Immunology and Allergy - Published
- 2022
26. Emergence du syndrome pollen aliment chez les enfants asthmatiques à Paris
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M. Bourgoin-Heck, Stéphanie Wanin, Christine Loraud, Nathalie Cottel, J. Just, and C. De Ménonville
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Immunology and Allergy - Abstract
Introduction Au cours des dernieres decennies, le niveau de pollen de bouleau et de groupes d’arbres homologues a augmente en Europe. La sensibilisation aux allergenes de pollen de bouleau (principalement Bet v 1) est associee a une allergie croisee aux aliments appelee syndrome pollen aliment (PFAS = pollen food allergy syndrome). L’objectif de l’etude etait d’evaluer l’evolution des maladies atopiques et de la sensibilisation allergenique sur une periode de 25 ans chez des enfants asthmatiques. Methodes Il s’agissait d’une etude retrospective transversale realisee a Paris. Nous avons analyse deux cohortes d’enfants asthmatiques de caracteristiques similaires, explores entre 1993–1999 (« ancienne cohorte » = OC) et 2012–2018 (« cohorte recente » = RC). Resultats Un total de 121 enfants ont ete inclus dans l’OC et 120 dans la RC. Une augmentation de la sensibilisation aux pollens d’arbres a ete retrouvee, en particulier au pollen de bouleau, allant de 11,6 % dans l’OC a 31 % dans la RC (p = 0,0002). La prevalence de la rhinite allergique etait significativement plus elevee dans la RC que dans l’OC (respectivement 96 % vs 52 %, p Conclusion La rhinite allergique, l’allergie alimentaire et la sensibilisation aux pollens d’arbres ont augmente a Paris sur 25 ans, principalement a cause du PFAS. Les facteurs environnementaux pourraient etre responsables de ces modifications comme decrits dans la litterature.
- Published
- 2021
27. Data report: evaluation of shipboard magnetostratigraphy by alternating field demagnetization of discrete samples, Expedition 361, Site U1475
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S.K.V. Hines, Thibaut Caley, D. Tangunan, Masako Yamane, X. Han, Stephen Barker, Jeroen van der Lubbe, Ian Hall, John M. Rolison, Nambiyathodi Lathika, Richard D Norris, Janna Just, Kaoru Kubota, A.M. Franzese, J. Just, M.H. Simon, J.G. Crespin, Nina Rooks-Cast, Jens Gruetzner, Francisco José Jiménez Espejo, Christopher D. Charles, Alejandra Catagena-Sierra, Melissa A. Berke, Leah J. LeVay, Thiago Pereira dos Santos, Andreas Koutsodendris, Rebecca S. Robinson, Hucai Zhang, Sidney R. Hemming, J.J. Coenen, and L. Brentegani
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Paleomagnetism ,Field (physics) ,Natural remanent magnetization ,Remanence ,Polarity (physics) ,Demagnetizing field ,Geophysics ,International Ocean Discovery Program ,Geology ,Magnetostratigraphy - Abstract
The paleomagnetic shipboard data of International Ocean Discovery Program Site U1475, with a record reaching back to approximately 7 Ma, allowed for the identification of major magnetic polarity chrons and subchrons back to ~3.5 Ma. However, the natural remanent magnetization (NRM) was very weak, and transitional intervals with unclear polarity were as thick as several meters. The midpoints of these transitional intervals were reported in the shipboard results without decimal places because of the poor data quality. To evaluate and possibly refine the shipboard magnetostratigraphy, subsampling was performed across the polarity transitions. Detailed alternating field (AF) demagnetization experiments were conducted on these discrete samples and were complemented by anhysteretic remanent magnetization acquisition measurements and subsequent demagnetization. AF demagnetization data of NRM were analyzed using anchored principal component analysis (PCA) to obtain the characteristic remanent magnetization. These PCA results generally confirm the smoothed signal across polarity transitions at Site U1475. However, the midpoint depths of the top of the Keana Subchron, the Gauss-Matuyama and Matuyama-Brunhes boundaries, and the base of the Olduvai Subchron were adjusted.
- Published
- 2020
28. Cartographie de l’offre de soins en allergologie en France en 2020
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Frédéric Bérard, Isabelle Bosse, S. Lefevre, Pascal Demoly, J.F. Fontaine, C. Rolland, Philippe Bonniaud, F. de Blay, J. Just, Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Hôpital Cognacq-Jay, Association Asthme et Allergies, Service de Pneumologie Soins Intensifs, Appareillage Respiratoire [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), and Les Hôpitaux Universitaires de Strasbourg (HUS)
- Subjects
030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,[SDV]Life Sciences [q-bio] ,Immunology and Allergy - Abstract
Resume A la suite de la reconnaissance de l’allergologie comme specialite, la FFAL a travaille avec le ministere des Solidarites et de la Sante dans le but d’elaborer une cartographie de l’offre de soins en allergologie en France. Un questionnaire electronique a ete diffuse par le biais des newsletters des differentes instances de l’allergologie francaise. Les resultats de ce questionnaire sont presentes et analyses dans cet article.
- Published
- 2020
29. Allergologie : une spécialité à l’heure des parcours de soins
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J.F. Fontaine, J. Just, pour la Fédération française d’allergologie, Pascal Demoly, Philippe Bonniaud, and Isabelle Bosse
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy ,030212 general & internal medicine - Abstract
Resume La Federation francaise d’allergologie, apres un etat des lieux de l’offre de soins en 2011 a realise deux enquetes aupres des enseignants en allergologie et des allergologues, enquetes centrees sur l’offre et le parcours de soins. Celles-ci s’integrent dans la continuite des propositions du livre blanc de 2017 sur les allergies respiratoires severes. La mise en place de parcours de soins est l’un des enjeux majeurs pour les annees a venir. Ces enquetes permettent de mettre a jour l’offre, de voir quels sont les contraintes et atouts de la profession pour instaurer ces parcours coordonnes et les initiatives deja en place. La Federation deplore la perte de la moitie des allergologues ces dix dernieres annees mais se rejouit de la mise en lumiere de plus de quarante initiatives lui faisant emettre six propositions pour favoriser une dynamique de parcours de soins en allergologie pour les annees a venir.
- Published
- 2018
30. Alergia respiratoria en el niño
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Flore Amat, M. Bourgoin-Heck, N. Lambert, and J. Just
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,business.industry ,Medicine ,030212 general & internal medicine ,business ,Humanities - Abstract
La alergia respiratoria puede manifestarse por un asma alergica y/o por una rinitis alergica. La rinitis alergica provoca una importante alteracion de la calidad de vida, deformidades del macizo facial en el nino, sindrome de apnea del sueno e incluso una evolucion secundaria hacia asma. La alergia respiratoria se asocia a asma en el 50-80% de los ninos asmaticos. Se trata del primer factor de riesgo de asma persistente durante la infancia. La alergia respiratoria se asocia a un peor control del asma y a un incremento de la necesidad de cuidados medicos. Su deteccion precoz y su diagnostico son por lo tanto parte integrante de la actitud terapeutica de todo paciente asmatico. Su tratamiento permite prevenir posibles factores desencadenantes de exacerbacion del asma y se basa en medidas relativas al entorno y en la inmunoterapia especifica, incluso un tratamiento biologico cuando el asma es grave.
- Published
- 2018
31. Prise en charge en 2019 des manifestations atopiques de l’enfant
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J. Just
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Immunology and Allergy - Published
- 2019
32. Omalizumab could be effective in children with severe eosinophilic non-allergic asthma
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JP Magny, M. Bourgoin-Heck, C Trouvé, J. Just, N. Lambert, Alfred Bernard, and Flore Amat
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Male ,0301 basic medicine ,Adolescent ,Asthma phenotypes ,Immunology ,Omalizumab ,macromolecular substances ,Anti-asthmatic Agent ,03 medical and health sciences ,0302 clinical medicine ,Eosinophilia ,Eosinophilic ,medicine ,Humans ,Immunology and Allergy ,Anti-Asthmatic Agents ,Child ,Asthma ,business.industry ,medicine.disease ,Steroid resistant ,Treatment Outcome ,030104 developmental biology ,030228 respiratory system ,Pediatrics, Perinatology and Child Health ,Non allergic ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Authors declare no relevant conflicts of interest related to the present work. Severe eosinophilic non-allergic asthma is a rare phenotype that could be effectively treated by omalizumab, especially when associated with elevated total serum IgE and nasal polyposis. Severe eosinophilic non-allergic asthma is a specific phenotype, rarely described in children, sometimes associated with nasal polyposis and aspirin intolerance (i.e., Widal's syndrome). This asthma phenotype is known to be particularly severe and steroid resistant (1). This article is protected by copyright. All rights reserved.
- Published
- 2017
33. Oral immunotherapy: Raw or baked milk?
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Antoine Deschildre, J. Just, M. Bourgoin-Heck, Nathalie C. Lambert, Flore Amat, Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Allergologie pédiatrique [CHU Trousseau], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
medicine.medical_specialty ,Oral immunotherapy ,Potential risk ,business.industry ,food and beverages ,Milk allergy ,[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy ,Raw milk ,medicine.disease ,3. Good health ,Highly sensitive ,03 medical and health sciences ,fluids and secretions ,0302 clinical medicine ,030228 respiratory system ,Severe phenotype ,Immunology ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,business ,Adverse effect ,Intensive care medicine ,Baked milk - Abstract
International audience; Avoidance is currently the only accepted form of management for children with cow's milk allergy. Oral immunotherapy has emerged as a promising alternative but carries the potential risk of anaphylactic adverse reaction. Baked milk seems to be safer than raw milk in most cases. However, severe adverse events continue to pose a real threat even in oral immunotherapy programs using baked milk. While many patients undergo successful oral immunotherapy without major safety issues, this is not the case for all patients. The benefits of oral immunotherapy with baked milk in speeding up recovery in children with a severe phenotype of cow's milk allergy should be carefully evaluated at specialized centers equipped to manage highly sensitive patients.; Le régime d’éviction est actuellement la seule prise en charge recommandée pour les enfants ayant une allergie aux protéines du lait de vache. L’immunothérapie par voie orale est considérée de plus en plus comme une alternative prometteuse au régime d’éviction, mais n’est pas exempte de risque de réactions anaphylactiques. L’utilisation de lait cuit semble réduire ce risque en comparaison du lait cru, sans l’annuler complètement. En effet, si la plupart des enfants peuvent suivre ce type de protocole sans effet indésirable majeur, cela n’est pas le cas pour tous. En particulier, le bénéfice du recours au lait cuit dans l’accélération de la guérison chez les enfants ayant un phénotype d’allergie aux protéines du lait de vache sévère (anaphylaxie à seuil bas notamment, multimorbidité atopique) devrait être évalué de façon prudente, collégiale et multidisciplinaire, dans des centres habilités à prendre en charge ces patients hautement réactifs.
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- 2017
34. Position Statement on Alcohol From the National Heart Foundation of Australia
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A. Buttery, B. Meertens, J. Just, G. Jennings, and J. Porter
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Pulmonary and Respiratory Medicine ,Position statement ,business.industry ,Law ,Medicine ,Foundation (evidence) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
35. Analyse d’une cohorte de patients pédiatriques adressés pour suspicion d’hypersensibilité médicamenteuse
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A.C. De Ménibus, M. Bourgoin-Heck, S. Wanin, J. Just, C. Paluel-Marmont, S. Saf, N. Cottel, and N. Lambert
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Immunology and Allergy - Abstract
Introduction Les suspicions d’hypersensibilites medicamenteuses (HSM) sont frequentes mais rarement confirmees. L’absence de diagnostic clair au terme d’explorations represente un probleme de sante publique. Les donnees epidemiologiques concernant les HSM sont encore faibles, notamment dans la population pediatrique. Methodes Notre objectif principal etait d’etudier dans une cohorte d’enfants adresses pour suspicion d’HSM dans un service universitaire pediatrique d’allergologie, le taux d’HSM avere au terme des explorations. Notre objectif secondaire etait d’analyser le profil de cette cohorte afin de proposer une optimisation des explorations au sein de notre service. Nous avons realise une etude retrospective mono-centrique, dans laquelle tous les enfants adresses pour suspicion d’HSM avec une chronologie compatible avec ce diagnostic, entre mai 2017 et mai 2018, dans le service d’allergologie pediatrique de l’Hopital Trousseau, ont ete inclus. Les explorations comprenaient d’eventuels tests cutanes et un test de provocation au medicament suspect selon les resultats des tests cutanes s’ils avaient ete fait. Resultats Nous avons inclus 129 enfants sur cette periode, correspondant a 140 reactions differentes suspectes d’HSM. Le nombre de reactions suspectes d’HSM etait respectivement de 124 (88,6 %) pour les betalactamines, 8 (5,7 %) pour les anti-inflammatoire non steroidiens (AINS) et paracetamol, et 8 (5,7 %) pour d’autres medicaments. Au terme des explorations, 6 (4,7 %) patients ont eu le diagnostic d’HSM confirmee : 5 (3,9 %) apres test de provocation et 1 (0,8 %) suite aux tests cutanes. L’Amoxicilline (± acide clavulanique) et les AINS/paracetamol etait pour chacune responsable de la moitie des HSM confirmee. Aucune reaction severe n’a ete rapportee. Discussion Environ 10 % des parents rapportent une suspicion d’allergie a un medicament chez leur enfant, ce qui est rarement confirme. Dans notre etude, moins de 5 % (6/129) des patients adresses pour une suspicion d’HSM ont eu une confirmation de ce diagnostic. Conclusion Une tres faible proportion des HSM suspectee a ete confirmee dans notre etude. Une simplification des explorations a ete proposee suite a cette etude.
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- 2021
36. Recommandations de la Société Française d’Allergologie. Indications des actes allergologiques en Hôpital de Jour
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F. de Blay, A. Barbaud, Carine Metz-Favre, C. Mailhol, A. Baron-Thurotte, Philippe Bonniaud, François Lavaud, N. Petit, J. Just, Joëlle Birnbaum, Catherine Neukirch, Antoine Magnan, M. Drouet, E. Beaudouin, Cindy Barnig, Antoine Deschildre, Pascal Demoly, Alain Didier, Claude Ponvert, Christine Sauvage, and J.-M. Perotin
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030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,business.industry ,Immunology and Allergy ,Medicine ,business - Published
- 2017
37. Assessing the serum concentration levels of NT-4/5, GPX-1, TNF-α, and l -arginine as biomediators of depression severity in first depressive episode patients with and without posttraumatic stress disorder
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Adam R. Szromek, Ewa Ogłodek, Aleksander Araszkiewicz, and Marek J. Just
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Adult ,Male ,medicine.medical_specialty ,GPX1 ,Arginine ,Receptors, Nerve Growth Factor ,behavioral disciplines and activities ,Gastroenterology ,Stress Disorders, Post-Traumatic ,Young Adult ,03 medical and health sciences ,Sex Factors ,Glutathione Peroxidase GPX1 ,0302 clinical medicine ,Pharmacotherapy ,Internal medicine ,mental disorders ,medicine ,Humans ,Depression (differential diagnoses) ,computer.programming_language ,Pharmacology ,Glutathione Peroxidase ,Depression ,Tumor Necrosis Factor-alpha ,sed ,General Medicine ,Middle Aged ,Serum concentration ,030227 psychiatry ,Posttraumatic stress ,Female ,Tumor necrosis factor alpha ,Psychology ,computer ,Biomarkers ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Background Neurotrophin-4/5 (NT-4/5) and glutathione peroxidase-1 (GPX-1) have been shown to play a major role in neuronal processes including depression and posttraumatic stress disorder (PTSD). They protect the body from oxidative damage by affecting neuronal growth, development and plasticity. The aim of the study was to evaluate the concentrations of NT-4/5, GPX-1, tumor necrosis factor-α (TNF-α), and l -arginine in patients suffering from varying levels of depression severity, PTSD, and depression comorbid with PTSD. Methods The study involved 460 participants, 360 of whom were diagnosed with different types of depressive episodes. They included: 60 patients with mild depression (MD), 60 patients with moderate depression (MOD), 60 patients with severe depression (SeD), 60 patients with MD and PTSD (MD + PTSD), 60 patients with MOD and PTSD (MOD + PTSD), 60 patients with SeD and PTSD (SeD + PTSD), and 60 patients with PTSD alone. Each group of 60 subjects comprised 30 females and 30 males. The control group comprised 40 subjects. The 10th revision of the International Statistical Classification of Diseases and Related Health Problems was utilized to diagnose depression and PTSD. At 7 a.m. blood samples were collected and serum NT-4/5, GPX-1, TNF-α and l -arginine concentrations were assessed using the ELISA method. Results Depressive episodes with and without PTSD and PTSD alone became more severe as the levels of TNF-α, l -arginine increased and the levels of NT-4/5, GPX-1 decreased. Conclusion l -arginine, TNF-α, NT-4/5 and GPX-1 can be markers of depression severity in both males and females with first depressive episode with or without posttraumatic stress disorder.
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- 2017
38. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly ( <scp>MACVIA</scp> ‐ <scp>ARIA</scp> ) ‐ <scp>EIP</scp> on <scp>AHA</scp> Twinning Reference Site ( <scp>GARD</scp> research demonstration project)
- Author
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Alan Estrada-Cardona, Désirée Larenas-Linnemann, A. A. Cruz, A. Bedbrook, Torsten Zuberbier, B. De Martino, Esben Eller, K. C. Bergmann, A. Farsi, Ana Maria Carriazo, João Fonseca, Manuel Teixeira Veríssimo, Carsten Bindslev-Jensen, S. La Grutta, G. De Feo, Rimantas Stukas, M Doulapsi, Jean-Louis Pépin, Adnan Custovic, Gabrielle L. Onorato, Oliver Pfaar, U. Trama, Timo E. Strandberg, Ana Margarida Pereira, M. Bochenska Marciniak, V. Tibaldi, M. H. Garcia Cruz, Juan Carlos Ivancevich, Alessandro Vatrella, Denis Caillaud, Tuula Vasankari, J. A. Rizzo, Robyn E O'Hehir, Anne Lise Courbis, D. Lauri, Benoit Pugin, José Luis Gálvez-Romero, Juan José Matta-Campos, Jean Bousquet, G. De Vries, Johanna Salimäki, A. Yorgancioglu, A. Ciceran, C. Dario, Luc Colas, W. J. Fokkens, J. Millot-Keurinck, Josep M. Antó, I. Annesi-Maesano, F. Corti, Nick A. Guldemond, Renzo Angles, Arūnas Valiulis, Vicky Kritikos, Martin Wagenmann, J Mullol, G. Canfora, Peter Hellings, M. T. Ventura, Bilun Gemicioglu, Martín Bedolla-Barajas, Elísio Costa, M. Guidacci, Milan Sova, Isabelle Bosse, Jesús Guillermo Espinoza-Contreras, D. Conforti, J. Correia de Sousa, M. Sorlini, Massimo Triggiani, Jorge Maspero, Maciej Kupczyk, Rachel Tan, Jean-François Ferrero, D Caiazza, N. Di Carluccio, O. Kalayci, L. Lewis, Javier Gómez-Vera, Antoine Magnan, J. Farrell, T. Dedeu, I. Bogus-Buczynska, J. Just, Erkka Valovirta, Frederic Viart, Daniel Laune, Marco Nalin, Regina Roller-Wirnsberger, A. Szylling, Caterina Bucca, G. Castellano, Davide Caimmi, V. Stroetmann, Filip Raciborski, Rafael Stelmach, Luiana Hernández-Velázquez, Violeta Kvedariene, E. Bacci, Maurizio Romano, Cemal Cingi, A. C. Pozzi, Marit Westman, I. Young, S. Forti, M. T. Burguete Cabañas, Bolesław Samoliński, Ruta Dubakiene, E. Zernotti, A. Blua, Ioana Agache, B. A. Barreto, João O. Malva, J. Lavrut, Thomas Keil, Miguel Alejandro Medina-Ávalos, C. I. García-Cobas, Jorge A. Luna-Pech, J. F. Fontaine, R. Emuzyte, Biljana Cvetkovski, Ruth Murray, Giovanni Rolla, Antonella Muraro, Jussi Karjalainen, H. Neffen, E Cousein, Claus Bachert, V. Kolek, Magnus Wickman, Elaine Colgan, Mario R. Romano, Miguel A. Sierra, Erik Melén, A. Senn, Paulo Augusto Moreira Camargos, C. Cartier, Jawad Hajjam, Ali Fuat Kalyoncu, S. Shamai, Sinthia Bosnic-Anticevich, L. Cecci, Renaud Louis, Ana Todo-Bom, Rodolphe Bourret, Enrica Menditto, Nikolaos G. Papadopoulos, M. M. Ciaravolo, Emmanuel P. Prokopakis, G. Passalacqua, P. V. Tomazic, Edgardo Jares, C. Robalo-Cordeiro, L. Bertorello, M. Bewick, Roland Buonaiuto, A. Romano, Sîan A Williams, Anabela Mota-Pinto, Marcello Persico, Luigi Napoli, M. Lessa, Ralph Mösges, G. Levato, M. Nogues, Tari Haahtela, Edyta Krzych-Fałta, Janet Rimmer, F. de Blay, A. Zurkuhlen, Ludger Klimek, I. Baroni, Niels H. Chavannes, Faradiba Sarquis Serpa, T. Bieber, E. Asayag, Yves Dauvilliers, Piotr Lacwik, R. M. Cortés-Grimaldo, Piotr Kuna, Cristiana Stellato, A Valero, J. da Silva, M. Illario, S Birov, R. Gerth van Wijk, M. R. Aliberti, Inger Kull, Z. Gutter, Sanna Toppila-Salmi, Gérard Dray, Sylvie Arnavielhe, Victoria Cardona, M. Morais-Almeida, Guy Joos, S. Di Capua Ercolano, J. Coll, M. van Eerd, C. Wanscher, N. Khaltaev, Agnieszka Lipiec, Mónica Rodríguez-González, Oscar Mayora, Pascal Demoly, G. Moda, S. Palkonen, I. Lieten, and B. De Oliviera
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Gerontology ,Allergy ,Carat ,medicine.medical_specialty ,Visual analogue scale ,business.industry ,Immunology ,Alternative medicine ,medicine.disease ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,030228 respiratory system ,medicine ,Physical therapy ,Immunology and Allergy ,Multimorbidity ,030212 general & internal medicine ,business ,health care economics and organizations ,Asthma - Abstract
The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives whilst ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study was to transfer innovation from an app developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i.e. the Allergy Diary and CARAT: Control of Allergic Rhinitis and Asthma Test) in 22 Reference Sites or regions across Europe. This will improve the understanding, assessment of burden, diagnosis and management of rhinitis in the elderly by comparison with an adult population. Specific objectives will be: (i) to assess the percentage of adults and elderly who are able to use the Allergy Diary, (ii) to study the phenotypic characteristics and treatment over a 1-year period of rhinitis and asthma multimorbidity at baseline (cross-sectional study) and (iii) to follow-up using visual analogue scale (VAS). This part of the study may provide some insight into the differences between the elderly and adults in terms of response to treatment and practice. Finally (iv) work productivity will be examined in adults.
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- 2017
39. Biomarqueurs associés au contrôle de l’asthme allergique de l’enfant
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M. Bourgoin-Heck, Flore Amat, Nathalie C. Lambert, and J. Just
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy ,030212 general & internal medicine - Abstract
Resume L’asthme allergique necessite une evaluation clinique reguliere afin de proposer une prise en charge therapeutique adaptee et personnalisee. Differents biomarqueurs correles au non controle de l’asthme et a l’activite inflammatoire sous-jacente ont ete etudies. Parmi eux, l’eosinophilie pulmonaire evaluee par la FeNO et l’eosinophilie sanguine mesuree soit directement soit par le taux serique d’ECP semblent, surtout lorsqu’elles sont elevees de facon concomitante, le reflet d’une inflammation systemique plus difficile a maitriser, mais qui serait sensible a l’action anti-inflammatoire globale de l’omalizumab.
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- 2017
40. Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study
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Olivier Vandenplas, R. Murray, Niels H. Chavannes, Erkka Valovirta, A. Fink-Wagner, Alvaro A. Cruz, Joaquim Mullol, Aziz Sheikh, G. De Vries, T. Keil, M. Wickman, K. C. Bergmann, Pascal Demoly, Dermot Ryan, Nick A. Guldemond, Torsten Zuberbier, V. Kvedariene, Luís Nogueira-Silva, Mikael Kuitunen, A. Valiulis, G. Passalacqua, Claus Bachert, Davide Caimmi, Antonella Muraro, E Mathieu-Dupas, João Fonseca, P V Tomazic, Jean Bousquet, P. Devillier, S. Arnavielhe, Pedro Carreiro-Martins, Erik Melén, Giorgio Walter Canonica, D. Laune, Nikolaos G. Papadopoulos, M. Bewick, Ronald Dahl, A. Valero, B. Hellqvist-Dahl, Peter Hellings, B. Samolinski, L. Klimek, S. van der Meulen, J. Just, M. Morais-Almeida, David Price, Tari Haahtela, O. Spranger, A. Todo Bom, Ana Margarida Pereira, M. van Eerd, F. Portejoie, M. L. Kowalski, A. Bedbrook, Piotr Kuna, Valérie Siroux, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon ( MACVIA-LR ), Université Montpellier 1 ( UM1 ) -World Health Organization ( WHO/OMS ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre Hospitalier Régional Universitaire de Nîmes ( CHRU Nîmes ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -European Innovation Partnership on Active and Healthy Ageing Reference Site, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique ( VIMA ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Hôpital Foch [Suresnes], Department of Dermatology, Medical School-Charité - University Medicine Berlin, Forschungszentrum Jülich GmbH - Projektträger BEO, GmbH, Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Arnaud de Villeneuve, Institut Pierre Louis d'Epidémiologie et de Santé Publique ( iPLESP ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Universidade de Lisboa ( ULISBOA ), Service d'allergologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], Institut de Recherche en Infectiologie de Montpellier ( IRIM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Allergy Department, 2nd Pediatric Clinic, Allergy & Respiratory Diseases, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw-Faculté de Pharmacie de Paris, Center for Public Health Research ( CSISP ), University of Valencia, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Department of Molecular Medicine and Surgery, Karolinska Institutet [Stockholm], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de Lisboa = University of Lisbon (ULISBOA), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Center for Public Health Research (CSISP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universidade de Lisboa (ULISBOA), Service d'Allergologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Health Services Management & Organisation (HSMO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and University of Genoa (UNIGE)-Department of Internal Medicine (DIMI)
- Subjects
0301 basic medicine ,EIP on AHA ,Pediatrics ,medicine.medical_specialty ,Allergen immunotherapy ,Pathology ,Allergy ,[SDV]Life Sciences [q-bio] ,Immunology ,Pilot Projects ,Review ,Asymptomatic ,03 medical and health sciences ,Allergic ,0302 clinical medicine ,HDE ALER ,Surveys and Questionnaires ,Journal Article ,medicine ,Humans ,Immunology and Allergy ,Rhinitis ,Asthma ,Allergy Diary ,rhinorrhea ,[ SDV ] Life Sciences [q-bio] ,business.industry ,Research ,MASK-rhinitis ,Baseline data ,Conjunctivitis ,medicine.disease ,Rhinitis, Allergic ,Mobile Applications ,3. Good health ,Europe ,Mobile technology ,mobile technology ,030104 developmental biology ,030228 respiratory system ,Baseline characteristics ,allergen immunotherapy ,medicine.symptom ,business ,Cell Phone ,Nasal symptoms - Abstract
The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). AIMS: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions. METHODS: The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1-2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms. RESULTS: By 1 June 2016, 3260 users had registered with the Allergy Diary and 2710 had completed the baseline questionnaire. Troublesome symptoms were found mainly in the users with the most symptoms. Around 50% of users with troublesome rhinitis and/or ocular symptoms suffered work impairment. Sleep was impaired by troublesome symptoms and nasal obstruction. CONCLUSIONS: This is the first App (iOS and Android) to have tested for allergic rhinitis and conjunctivitis. A simple questionnaire administered by cell phones enables the identification of phenotypic differences between a priori defined rhinitis groups. The results suggest novel concepts and research questions in allergic rhinitis that may not be identified using classical methods info:eu-repo/semantics/publishedVersion
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- 2017
41. Place des nouvelles technologies dans la prise en charge des patients allergiques
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E. Dupas, I. Annesi-Maesano, Daniel Laune, Davide Caimmi, A. Bedbrook, Jean Bousquet, M. Thibaudon, Pascal Demoly, Gabrielle L. Onorato, D. Charpin, J.F. Fontaine, I. Bossé, Sylvie Arnavielhe, P. Devillier, J. Just, and C. Rolland
- Subjects
0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy - Abstract
Resume MASK-rhinite (Mobile Airways Sentinel Network pour la rhinite allergique et la multimorbidite de l’asthme) est un systeme de technologie de l’information et des communications (TIC) centre sur le patient. Une application gratuite pour telephones mobiles (appelee Allergy Diary) a ete developpee et lancee dans 23 pays. Plusieurs resultats obtenus par MASK permettent d’avoir une approche plus proche des besoins du patient allergique. MASK permettra une meilleure approche de l’automedication, de la medecine personnalisee et de l’autonomisation des patients.
- Published
- 2018
42. Épidémiologie des effets secondaires de l’immunothérapie allergénique
- Author
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M. Bourgoin-Heck, C. Paluel-Marmont, P. Tallon, Flore Amat, N. Lambert, and J. Just
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03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy ,030212 general & internal medicine - Abstract
Resume L’immunotherapie allergenique est connue depuis longtemps en allergie respiratoire, dans sa modalite sublinguale ou sous-cutanee. L’immunotherapie allergenique par voie orale est utilisee plus recemment dans l’allergie alimentaire. Il est propose d’evaluer, dans une revue narrative de la litterature, la frequence et les facteurs de risque de leurs effets indesirables eventuels.
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- 2018
43. La dermatite atopique au sein des autres maladies atopiques : première étape du syndrome de multi-morbidité atopique ? Analyse de la littérature
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M. Bourgoin-Heck, J. Just, C. Paluel-Marmont, N. Lambert, Flore Amat, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030225 pediatrics ,[SDV]Life Sciences [q-bio] ,Immunology and Allergy ,3. Good health - Abstract
Resume Les mecanismes physiopathologiques de la dermatite atopique (DA) varient en fonction du phenotype, de l’âge de debut, de la severite de la maladie, du fond genetique et des facteurs declenchants. Un groupe de patients plus difficile a traiter caracterise par un debut precoce de la maladie, une persistance de celle-ci au cours de la vie et une association a l’asthme et/ou a l’allergie alimentaire, a ete identifie. L’hypothese physiopathologique de la marche atopique, passage de la DA a l’asthme, correspondrait a un defaut primitif de barriere, auto-entretenu par une sensibilisation allergenique secondaire. D’autre part, la severite de la DA semble etre un facteur de risque d’allergie alimentaire associee. Les resultats issus de cohortes en population generale, de cohortes neonatales et de cohortes de patients montrent que la DA a debut precoce, le sexe masculin, l’antecedent parental d’asthme, ainsi que la sensibilisation precoce et multiple sont des facteurs de risque d’entree dans la marche atopique. Le role des facteurs environnementaux chez ces enfants ne doit pas etre minimise pour favoriser l’emergence de programme de prevention. La therapie precoce par emollient est une approche interessante pour prevenir la DA chez les nourrissons a haut risque, mais n’a pas fait la preuve de son efficacite dans la prevention de la marche atopique. En pratique clinique, il est egalement essentiel de garder en tete les risques specifiques lies aux mutations de la filaggrine.
- Published
- 2019
44. ‘Sticky Blood’: A Partnership Approach to Amplifying an Advertising Campaign on the Effects of Smoking on Cardiovascular Disease Risk
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A. Mark, S. White, J. Just, S. Durkin, K. Dienaar, J. Mitchell, N. Cox, I. Baratta, and R. Whiffen
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Pulmonary and Respiratory Medicine ,Advertising campaign ,business.industry ,Environmental health ,General partnership ,Disease risk ,Medicine ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
45. Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity
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Adam R. Szromek, Marek J. Just, Ewa Ogłodek, and Aleksander Araszkiewicz
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Adult ,Male ,medicine.medical_specialty ,medicine.disease_cause ,Neuroprotection ,Melatonin ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Neurotrophin 3 ,Neurotrophic factors ,Internal medicine ,Nerve Growth Factor ,medicine ,Humans ,Nerve Growth Factors ,Circadian rhythm ,Depression (differential diagnoses) ,Pharmacology ,Depressive Disorder ,Neuronal Plasticity ,biology ,Depression ,Brain-Derived Neurotrophic Factor ,Brain ,General Medicine ,Middle Aged ,030227 psychiatry ,Endocrinology ,Nerve growth factor ,nervous system ,biology.protein ,Female ,Psychology ,030217 neurology & neurosurgery ,Oxidative stress ,Neurotrophin ,medicine.drug - Abstract
Background Disrupted circadian rhythm of melatonin secretion in depression shows a relationship with the exacerbation of inflammatory processes. Proinflammatory mechanisms of depression are sustained by oxidative stress. This contributes to melatonin deficiency and to the malfunction of the defense mechanisms in the brain. Disrupted melatonin secretion in depression may have an influence on the concentrations of neurotrophic factors (NF), such as neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Disturbance in neurotrophin release may affect synaptic plasticity and cause exacerbation of neurodegenerative processes in the central nervous system. The aim of this study was to assess the concentrations of melatonin and NF of the brain in patients with varying levels of depression severity. Method 160 males and females were enrolled in the study, 120 of whom were diagnosed with various types of depression. The control group comprised 40 healthy individuals. At 3:00 a.m. all patients had salivary melatonin concentrations determined utilizing a competitive enzyme immunoassay technique (ELISA). In addition, at 7:00 a.m. all patients had serum neurotrophin (NT-3, BDNF, NGF) concentrations determined by means of ELISA. Results The highest melatonin secretion was observed at 3:00 a.m. in severely depressed females. In the groups with mild and moderate depression, melatonin secretion at 3:00 a.m. was comparable between males and females. In addition, a decrease in the concentrations of neurotrophins was revealed in patients at all levels of depression severity. Conclusion Melatonin may be a significant marker of depression severity. Melatonin and NF in depressed patients show neuroprotective effects.
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- 2016
46. Paving the way of systems biology and precision medicine in allergic diseases: the Me <scp>DALL</scp> success story
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Erik Melén, Rudolph Valenta, Fanny Rancière, C. Tischer, I. Skrindo, Hamida Hammad, V. Anastasova, Leda Chatzi, C. Hohman, Magnus Wickman, M P Fantini, M. Torrent, Pascal Demoly, S. Palkonen, Esben Eller, Carsten Bindslev-Jensen, N. Anderson, A. Bedbrook, Torsten Zuberbier, Rachel Nadif, Francesco Forastiere, K. Wenger, Sybille Koletzko, I. Annesi-Maesano, Jonathan M. Coquet, Yvan Saeys, Joachim Heinrich, Steffen Lau, Marit Westman, Bénédicte Jacquemin, L. von Hertzen, M. Standl, Marta Benet, Martijn J. Schuijs, Mirela Curin, Dirkje S. Postma, Valérie Siroux, Bart N. Lambrecht, E. Minina, Christian Lupinek, Vegard Hovland, Irina Lehmann, Jordi Sunyer, Dieter Maier, Stephane Ballereau, Anna Asarnoj, Jean Bousquet, Isabelle Momas, A. Rial-Sebbag, Gerard H. Koppelman, Cezmi A. Akdis, Isabelle Pin, A. von Berg, Henriette A. Smit, Manolis Kogevinas, Beatrix Gerhard, Claus Bachert, Emilie Burte, S. Guerra, Sandra Wieser, Bert Brunekreef, Johann Pellet, Ulrike Gehring, Renata Kiss, Petter Mowinckel, Cheng-Jian Xu, Anne Cambon-Thomsen, Jordi Mestres, Theresa Keller, Martijn C. Nawijn, Ferran Ballester, N. Ballardini, Tari Haahtela, Mariona Pinart, Charles Auffray, J. Garcia-Aymerich, J. Just, R. Albang, Marek L. Kowalski, Marjan Kerkhof, Inger Kull, Mika J. Mäkelä, G. De Carlo, J. De Vocht, Kai-Håkon Carlsen, Sam Oddie, A. Arno, Rosemary R. C. McEachan, X. Basagana, Thomas Keil, Daniela Porta, M. Akdis, Anna Bergström, Nathanaël Lemonnier, Raphaëlle Varraso, John Wright, Josep M. Antó, K. C. Lødrup Carlsen, and D. Smagghe
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0301 basic medicine ,Allergy ,education.field_of_study ,business.industry ,Systems biology ,Immunology ,Population ,Atopic dermatitis ,Omics ,medicine.disease ,Precision medicine ,3. Good health ,Review article ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,Immunology and Allergy ,Medicine ,media_common.cataloged_instance ,European union ,business ,education ,media_common - Abstract
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
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- 2016
47. Étude des exacerbations d’asthme sévères admises dans un service de réanimation pédiatrique d’Ile de France durant 6 ans
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I. Haegy Döhring and J. Just
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Immunology and Allergy - Abstract
Introduction L’exacerbation d’asthme severe (EAS) est un motif d’hospitalisation frequent en reanimation pediatrique. L’objectif est de chercher l’element declenchant (virus, exposition aux allergenes) et quels traitements (medicamenteux, ventilation) sont efficaces selon les phenotypes. Methodes Etude monocentrique retrospective des patients admis dans le service de reanimation pediatrique de l’Hopital Raymond Poincare a Garches (AP–HP) pour exacerbation asthme severe entre janvier 2013 et decembre 2018. Analyse epidemiologique, microbiologique, tests allergologiques, therapeutique (medicamenteuse et ventilatoire), complications, duree d’hospitalisation, traitement de fond a la sortie. Resultats 99 patients ont ete hospitalises pour ESA ( Tableau 1 ). Les virus (rhinovirus et VRS) sont retrouves chez l’enfant prescolaire surtout en periode automno-hivernale. Les enfants en âge scolaire declenchent des crises volontiers en mai ou juillet (pics polliniques et de pollution). Discussion L’absence de diagnostic d’asthme avant l hospitalisation, la rupture de traitement et la non-maitrise du protocole d’urgence, l’exposition au tabac sont retrouves dans les autres series. Les virus (Rhinovirus et VRS) sont retrouves chez l’enfant prescolaire surtout en periode automno-hivernale. Les enfants en âge scolaire declenchent des crises volontiers en mai ou juillet (pics pollinique et de pollution). L’efficacite de la VNI se confirme et on constate une diminution des intubation et des complications. Conclusion Il faut continuer d’insister sur formation des professionnels et l’education therapeutique pour reduire les EAS.
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- 2020
48. Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study
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Ralph Mösges, T. Keil, Davide Caimmi, N. Ballardini, Thomas B. Casale, M. Morais Almeida, M. Rodriguez Gonzalez, Massimo Triggiani, Erik Melén, M. Wickman, Filip Raciborski, Sinthia Bosnic-Anticevich, P. V. Tomazic, Rafael Stelmach, Pascal Demoly, W. J. Fokkens, A. Bedbrook, Maciej Kupczyk, Jean Bousquet, K. C. Bergmann, A. Valero, M. T. Burguete Cabañas, Valérie Siroux, I. Annesi-Maesano, Torsten Zuberbier, Sanna Toppila-Salmi, Juan Carlos Ivancevich, A. Valiulis, Olivier Vandenplas, Ioana Agache, Frederic Viart, F. Portejoie, Cristiana Stellato, Josep M. Antó, D. Laune, V. Kvedariene, D. Larenas-Linnemann, J. da Silva, Ruth Murray, Piotr Kuna, Esben Eller, F. Sarquis-Serpa, Isabelle Bosse, Claus Bachert, P. Devillier, R. Bourret, M. L. Kowalski, Bilun Gemicioglu, Erkka Valovirta, Alvaro A. Cruz, M. Bewick, Tari Haahtela, O. Spranger, A. Yorgancioglu, Enrica Menditto, Aziz Sheikh, G. De Vries, Marit Westman, Oliver Pfaar, S. Arnavielhe, C. Cartier, G. Passalacqua, Dermot Ryan, S. Shamai, B. Samolinski, A. Todo Bom, Martin Sørensen, Inger Kull, M. van Eerd, Carsten Bindslev-Jensen, Niels H. Chavannes, Joaquim Mullol, T. Bieber, João Fonseca, G. Vezzani, Robyn E O'Hehir, Peter Hellings, M. T. Ventura, L. Klimek, J. Just, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Foch [Suresnes], University of Helsinki, 'Federico II' University of Naples Medical School, Département Chirurgie Pédiatrique [CHRU Montpellier], Pôle Femme Mère Enfant [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Heidelberg University, University of Barcelona, Karl-Franzens-Universität [Graz, Autriche], University of Turku, Vilnius University [Vilnius], University of Edinburgh, Ghent University Hospital, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], The University of Sydney, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Bousquet, J., Devillier, P., Anto, J. M., Bewick, M., Haahtela, T., Arnavielhe, S., Bedbrook, A., Murray, R., van Eerd, M., Fonseca, J. A., Morais Almeida, M., Todo Bom, A., Menditto, E., Passalacqua, G., Stellato, C., Triggiani, M., Ventura, M. T., Vezzani, G., Annesi-Maesano, I., Bourret, R., Bosse, I., Caimmi, D., Cartier, C., Demoly, P., Just, J., Portejoie, F., Siroux, V., Viart, F., Bergmann, K. C., Keil, T., Klimek, L., Mosges, R., Pfaar, O., Shamai, S., Zuberbier, T., Mullol, J., Valero, A., Spranger, O., Tomazic, P. V., Kowalski, M. L., Kuna, P., Kupczyk, M., Raciborski, F., Samolinski, B., Toppila-Salmi, S. K., Valovirta, E., Cruz, A. A., Sarquis-Serpa, F., da Silva, J., Stelmach, R., Larenas-Linnemann, D., Rodriguez Gonzalez, M., Burguete Cabanas, M. T., Kvedariene, V., Valiulis, A., Chavannes, N. H., Fokkens, W. J., Ryan, D., Sheikh, A., Bachert, C., Hellings, P. W., Vandenplas, O., Ballardini, N., Kull, I., Melen, E., Westman, M., Wickman, M., Bindslev-Jensen, C., Eller, E., Bosnic-Anticevich, S., O'Hehir, R. E., Agache, I., Bieber, T., Casale, T., Gemicioglu, B., Ivancevich, J. C., De Vries, G., Sorensen, M., Yorgancioglu, A., and Laune, D.
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Male ,Allergy ,SYMPTOMS ,IMPACT ,CHILDREN ,WORLD-HEALTH-ORGANIZATION ,Review ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Quality of life ,QUALITY-OF-LIFE ,conjunctiviti ,Prevalence ,conjunctivitis ,Immunology and Allergy ,Prospective Studies ,Young adult ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Child ,Prospective cohort study ,asthma ,multimorbidit ,rhinitis ,work productivity ,Nose ,Aged, 80 and over ,Respiratory organs diseases ,Middle Aged ,Mobile Applications ,3. Good health ,rhiniti ,medicine.anatomical_structure ,Research Design ,MEDALL ,GA(2)LEN ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,Life Sciences & Biomedicine ,Human ,Adult ,medicine.medical_specialty ,Adolescent ,multimorbidity ,Visual analogue scale ,Mobile Application ,Immunology ,MECHANISMS ,Malalties de l'aparell respiratori ,Young Adult ,03 medical and health sciences ,Internal medicine ,Hypersensitivity ,medicine ,Journal Article ,Humans ,asthma, conjunctivitis, multimorbidity, rhinitis, work productivity ,Aged ,Asthma ,Science & Technology ,business.industry ,medicine.disease ,Patient Outcome Assessment ,Prospective Studie ,Morbiditat ,030228 respiratory system ,Observational study ,Rhinithis ,VISUAL ANALOG SCALE ,Morbidity ,business - Abstract
BACKGROUND: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. METHODS: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels
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- 2018
49. Treatment of allergic rhinitis using mobile technology with real world data: The MASK observational pilot study
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Valérie Siroux, Cristiana Stellato, Olivier Vandenplas, Isabella Annesi-Maesano, P V Tomazic, A. Bedbrook, Luís Nogueira-Silva, M. Morais Almeida, Maddalena Illario, Wytske J. Fokkens, Piotr Kuna, Isabelle Bosse, Erik Melén, Joaquim Mullol, G Alexis-Alexandre, Esben Eller, Nikolaos G. Papadopoulos, Pascal Demoly, B. Samolinski, D. Larenas-Linnemann, Carsten Bindslev-Jensen, Peter McDowall, Ana Margarida Pereira, M. Bewick, Josep M. Antó, Torsten Zuberbier, A. Todo Bom, Pedro Carreiro-Martins, R. Murray, A. Yorgancioglu, F. Portejoie, Robyn E O'Hehir, E Murphy, Inger Kull, D. Laune, A. Valiulis, G. Passalacqua, T. Keil, Peter Hellings, M. L. Kowalski, Bilun Gemicioglu, Alvaro A. Cruz, P. Devillier, A. Valero, L. Klimek, Aziz Sheikh, G. De Vries, J. Just, Davide Caimmi, Niels H. Chavannes, K. C. Bergmann, João Fonseca, Erkka Valovirta, J. F. Fontaine, Dermot Ryan, S. Shamai, Massimo Triggiani, Enrica Menditto, Giorgio Walter Canonica, M. Wickman, Jean Bousquet, Sinthia Bosnic-Anticevich, Gabrielle L. Onorato, M. van Eerd, S. Arnavielhe, E Mathieu-Dupas, David Price, Tari Haahtela, O. Spranger, V. Kvedariene, Claus Bachert, R Mösgues, AII - Inflammatory diseases, Ear, Nose and Throat, AII - Amsterdam institute for Infection and Immunity, Other departments, Bousquet, J, Arnavielhe, S, Bedbrook, A, Alexis-Alexandre, G, van Eerd, M, Murray, R, Canonica, G W, Illario, M, Menditto, E, Passalacqua, G, Stellato, C, Triggiani, M, Carreiro-Martins, P, Fonseca, J, Morais Almeida, M, Nogueira-Silva, L, Pereira, A M, Todo Bom, A, Bosse, I, Caimmi, D, Demoly, P, Devillier, P, Fontaine, J F, Just, J, Onorato, G L, Kowalski, M L, Kuna, P, Samolinski, B, Anto, J M, Mullol, J, Valero, A, Tomazic, P V, Bergmann, K C, Keil, T, Klimek, L, Mösgues, R, Shamai, S, Zuberbier, T, Murphy, E, Mcdowall, Peter, Price, D, Ryan, D, Sheikh, A, Chavannes, N H, Fokkens, W J, Kvedariene, V, Valiulis, A, Bachert, C, Hellings, P W, Kull, I, Melén, E, Wickman, M, Bindslev-Jensen, C, Eller, E, Haahtela, T, Valovirta, E, Papadopoulos, N G, Annesi-Maesano, I, Bewick, M, Bosnic-Anticevich, S, Cruz, A A, De Vries, G, Gemicioglu, B, Larenas-Linnemann, D, Laune, D, Mathieu-Dupas, E, O'Hehir, R E, Portejoie, F, Siroux, V, Spranger, O, Vandenplas, O, Yorgancioglu, A, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], 'Federico II' University of Naples Medical School, CHU Montpellier, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Barcelona, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University Hospital of Cologne [Cologne], Department of Computer Science [Haifa], University of Haifa [Haifa], University of Edinburgh, Vilnius University [Vilnius], Ghent University Hospital, University Hospitals Leuven [Leuven], The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], University of Helsinki, The University of Sydney, Heidelberg University, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Turku, Department of Dermatology, Allergology and Venereology, Clinicum, and HUS Inflammation Center
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Research design ,Male ,IMPACT ,Pilot Projects ,Review ,Global Health ,law.invention ,DOUBLE-BLIND ,0302 clinical medicine ,FLUTICASONE ,Randomized controlled trial ,law ,QUALITY-OF-LIFE ,HDE ALER ,Immunology and Allergy ,Medicine ,AZELASTINE ,030212 general & internal medicine ,Prospective Studies ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,mHealth ,Randomized Controlled Trials as Topic ,treatment ,Disease Management ,mobile technology ,observational study ,rhinitis ,Middle Aged ,Combined Modality Therapy ,Mobile Applications ,3. Good health ,rhiniti ,Research Design ,GUIDED SELF-MANAGEMENT ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Over-the-counter ,Female ,mHealth, mobile technology, observational study, rhinitis, treatment ,medicine.drug ,Adult ,medicine.medical_specialty ,Immunology ,CONTROLLED-TRIAL ,Drug Prescriptions ,Medication Adherence ,03 medical and health sciences ,Young Adult ,Quality of life (healthcare) ,Journal Article ,Humans ,Asthma ,business.industry ,CARE ,medicine.disease ,Azelastine ,Rhinitis, Allergic ,030228 respiratory system ,3121 General medicine, internal medicine and other clinical medicine ,Physical therapy ,ASTHMA ,Observational study ,business ,TRADITIONAL TREATMENT - Abstract
BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology.METHODS: A mobile phone app (Allergy Diary, freely available Google Play and Apple App stores) collects the data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries.RESULTS: A total of 2,871 users filled in 17,091 days of VAS in 2015 and 2016. Medications were reported for 9,634 days. The assessment of days appeared to be more informative than the course of the treatment as, in real life, patients do not necessarily use treatment on a daily basis; rather, they appear to increase treatment use with the loss of symptom control. The Allergy Diary allowed differentiation between treatments within or between classes (intranasal corticosteroid use containing medications and oral H1-antihistamines). The control of days differed between no [best control], single or multiple treatments (worst control).CONCLUSIONS: The present study confirms the usefulness of the Allergy Diary in accessing and assessing everyday use and practice in allergic rhinitis. This pilot observational study uses a very simple assessment (VAS) on a mobile phone, shows novel findings and generates new hypotheses. This article is protected by copyright. All rights reserved.
- Published
- 2018
50. Sedimentological processes and environmental variability at Lake Ohrid (Macedonia, Albania) between 640 ka and present day
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A. Francke, B. Wagner, J. Just, N. Leicher, R. Gromig, H. Baumgarten, H. Vogel, J. H. Lacey, L. Sadori, T. Wonik, M. J. Leng, G. Zanchetta, R. Sulpizio, and B. Giaccio
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010504 meteorology & atmospheric sciences ,15. Life on land ,010502 geochemistry & geophysics ,01 natural sciences ,0105 earth and related environmental sciences - Abstract
Lake Ohrid (FYROM, Albania) is thought to be more than 1.2 million years old and hosts more than 200 endemic species. As a target of the International Continental Scientific Drilling Program (ICDP), a successful deep drilling campaign was carried out within the scope of the Scientific Collaboration on Past Speciation Conditions in Lake Ohrid (SCOPSCO) project in 2013. Here, we present lithological, sedimentological, and (bio-)geochemical data from the upper 247.8 m of the overall 569 m long DEEP site sediment succession from the central part of the lake. According to an age model, which is based on nine tephra layers (1st order tie points), and on tuning of biogeochemical proxy data to orbital parameters (2nd order tie points) and to the global benthic isotope stack LR04 (3rd order tie points), respectively, the analyzed sediment sequence covers the last 640 ka. The DEEP site sediment succession consists of hemipelagic sediments, which are interspersed by several tephra layers and infrequent, thin (< 5 cm) mass wasting deposits. The hemipelagic sediments can be classified into three different lithotypes. Lithotype 1 and 2 deposits comprise calcareous and slightly calcareous silty clay and are predominantly attributed to interglacial periods with high primary productivity in the lake during summer and reduced mixing during winter. The data suggest that high ion and nutrient concentrations in the lake water promoted calcite precipitation and diatom growth in the epilmnion in during MIS15, 13, and 5. Following a strong primary productivity, highest interglacial temperatures can be reported for MIS11 and 5, whereas MIS15, 13, 9, and 7 were comparable cooler. Lithotype 3 deposits consist of clastic, silty clayey material and predominantly represent glacial periods with low primary productivity during summer and longer and intensified mixing during winter. The data imply that most severe glacial conditions at Lake Ohrid persisted during MIS16, 12, 10, and 6 whereas somewhat warmer temperatures can be inferred for MIS14, 8, 4, and 3. Interglacial-like conditions occurred during parts of MIS14, and 8.
- Published
- 2015
- Full Text
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