128 results on '"J, Khalifa"'
Search Results
2. Stereotactic body radiation therapy for spine and non-spine bone metastases. GETUG (french society of urological radiation oncologists) recommendations using a national two-round modified Delphi survey
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F. Vilotte, D. Pasquier, P. Blanchard, S. Supiot, J. Khalifa, U. Schick, T. Lacornerie, L. Vieillevigne, D. Marre, O. Chapet, I. Latorzeff, N. Magne, E. Meyer, K. Cao, Y. Belkacemi, J.E. Bibault, M. Berge-Lefranc, J.C. Faivre, K. Gnep, V. Guimas, A. Hasbini, J. Lagrand-Escure, C. Hennequin, and P. Graff
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Stereotactic radiation therapy ,Stereotaxy ,Oligometastatic ,Metastasis-directed ,Spine bone metastasis ,Non-spine bone metastasis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Backround and purpose: The relevance of metastasis-directed stereotactic body radiation therapy (SBRT) remains to be demonstrated through phase III trials. Multiple SBRT procedures have been published potentially resulting in a disparity of practices. Therefore, the french society of urological radiation oncolgists (GETUG) recognized the need for joint guidelines for metastasis-directed SBRT in order to standardize practice in trials carried out by the group. Materials and methods: After a comprehensive litterature review, 97 recommandation statements were created regarding planning and delivery of spine bone (SBM) and non-spine bone metastases (NSBM) SBRT. These statements were then submitted to a national online two-round modified Delphi survey among main GETUG investigators. Consensus was achieved if a statement received ≥ 75 % agreements, a trend to consensus being defined as 65–74 % agreements. Any statement without consensus at round one was re-submitted in round two. Results: Tweny-one out of 29 (72.4%) surveyed GETUG investigators responded to both rounds. Consensus was achieved for 91/97 statements (93.8%) allowing the edition of comprehensive guidelines encompassing all aspects of SBM and NSBM SBRT planning and delivery: patients selection (19 statements), treatment preparation (14 statements), target volume delineation (18 statements), dose and fractionation (11 statements), prescription and dose objectives (9 statements), organs at risk dose constraints (15 statements) and image guided radiation therapy (11 statements). Conclusion: GETUG guidelines for SBM and NSBM SBRT were agreed upon using a validated modified Delphi approach. These guidelines will be used as per-protocol recommendations in ongoing and further GETUG clinical trials.
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- 2022
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3. Investigation the Influence of adding Nano –Yttria Partially Stabilized Zirconia (NZrO2-5wt%YPSZ) on the Physical and Mechanical Properties of Concrete
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Hadeel Z. Mahmoud, Zainab H.Naji, Salim F. Salman, Adel K. Mahmoud, Elyor Berdimurodov, Ahmed AAG Alrubaiy, Hutheifa J. Khalifa, and Hasan Okuyucu
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Nano Zirconia ,Building materials ,Nanoparticles ,Tensile strength ,Engineering machinery, tools, and implements ,TA213-215 ,Mechanics of engineering. Applied mechanics ,TA349-359 ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Chemical engineering ,TP155-156 ,Environmental engineering ,TA170-171 - Abstract
Building materials showed remarkable progress, as many methods were used to enhance their properties, such as nanomaterials which have played a major role in this field. This research reveals the complex integration of nano-zirconi (NZrO2-5wt%YPSZ). as with concrete and its effect on the different mechanical properties. The main objective of this research is to reduce the porosity of concrete by adding doses of nano-zirconia to the concrete mixture to enhance the microstructure, which enhances its mechanical properties. The results showed that the addition of nano-zirconia decreased concrete slump, and also increased the rates of absorption and porosity due to the agglomeration of nanoparticles. The compressive strength increased to reach 30, 47.5, and 60 MPa at the ages of 7, 28, and 90 days, respectively. The splitting tensile strength increased when the zirconia content was increased, reaching its highest level when substituting 0.7wt% when compared with the reference mixture. In summary, the current study sheds light on the effect of nano-zirconia on the mechanical properties of concrete by filling the pores, which enhances its microstructure because it reshapes the complex texture of the concrete mixture.
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- 2023
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4. Mechanical Properties of Austenitic Stainless Steel After Exposure to Elevated Temperature
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Salah Ganem, Mohammed Mahmood, and Hutheifa J. Khalifa
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Post-fire behaviour ,Structural stainless steel ,Coupon test ,Structural safety ,Engineering machinery, tools, and implements ,TA213-215 ,Mechanics of engineering. Applied mechanics ,TA349-359 ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Chemical engineering ,TP155-156 ,Environmental engineering ,TA170-171 - Abstract
Stainless steel has been widely used in the building industry as load-bearing elements such as beams and columns. Many fire accidents in stainless steel buildings were recorded, but only a few have collapsed entirely. These buildings can be rehabilitated and the undamaged parts can be reused, which reduces the economic losses in buildings exposed to fire. The residual mechanical properties of stainless steel after the fire, are the primary determinant of the validity of the stainless steel structure. In this paper, the effect of high temperatures and the time of exposure and cooling method on the mechanical properties of S304 stainless steel was studied. The specimens were heated to 800°C and 1000°C for different heating times (30, 60,90 and 120 minutes) and cooling methods (air-cooled and water-cooled). Results showed that the post-fire yield stress was reduced by 24% and 18% after heating to 800°C for 120minutes and cooled in water and air respectively. However, heating to 1000°C showed a marginal effect on the yield stress of air-cooled specimens and a clear reduction (29%) in the water-cooled specimens. Elongation capacity increased with heating time for 1000oC specimens but decreased for 800oC specimens in both cooling methods.
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- 2023
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5. Simple generic memristor emulator for voltage-controlled models.
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Abdullah G. Alharbi, Mohammed E. Fouda, Zainulabideen J. Khalifa, and Masud H. Chowdhury
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- 2016
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6. A new capacitor-less LED drive.
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Munir Ahmad Al-Absi, Zainulabideen J. Khalifa, and Alaa E. Hussein
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- 2016
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7. Subventricular zones: new key targets for glioblastoma treatment
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J. Khalifa, F. Tensaouti, A. Lusque, B. Plas, J.-A. Lotterie, A. Benouaich-Amiel, E. Uro-Coste, V. Lubrano, and E. Cohen-Jonathan Moyal
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Glioblastoma ,Radiotherapy ,Stem-cell niche ,Subventricular Zone ,Prognostic factors ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma. Methods Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified. All patients received surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral (iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively segmented and radiation dose-volume histograms were generated. Multivariate analysis using the Cox proportional hazards model was assessed to examine the relationship between prognostic factors and time to progression (TTP) or overall survival (OS). Results Median age was 59 years (range: 25–85). Median follow-up, OS and TTP were 22.7 months (range 7.5–69.7 months), 22.7 months (95% CI 14.5–26.2 months) and 6.4 months (95% CI 4.4–9.3 months), respectively. On univariate analysis, initial contact to SVZ was a poor prognostic factor for OS (18.7 vs 41.7 months, p = 0.014) and TTP (4.6 vs 12.9 months, p = 0.002). Patients whose bSVZ volume receiving at least 20 Gy (V20Gy) was greater than 84% had a significantly improved TTP (17.7 months vs 5.2 months, p = 0.017). This radiation dose coverage was compatible with an hippocampal sparing. On multivariate analysis, initial contact to SVZ and V20 Gy to bSVZ lesser than 84% remained poor prognostic factors for TTP (HR = 3.07, p = 0.012 and HR = 2.67, p = 0.047, respectively). Conclusion Our results suggest that contact to SVZ, as well as insufficient bSVZ radiation dose coverage (V20Gy
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- 2017
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8. Stratégie de préservation vésicale basée sur le traitement trimodal : quelle place dans la prise en charge du carcinome infiltrant de la vessie ?
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J. Khalifa, M. Roumiguié, D. Pouessel, and P. Sargos
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Oncology ,Radiology, Nuclear Medicine and imaging - Published
- 2022
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9. Mechanical Properties of Austenitic Stainless Steel After Exposure to Elevated Temperature
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Ganem, Salah, primary, Mahmood, Mohammed, additional, and J. Khalifa, Hutheifa, additional
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- 2023
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10. Electrical Nonlinearity Emulation Technique for Current-Controlled Memristive Devices.
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Abdullah G. Alharbi, Mohammed E. Fouda, Zainulabideen J. Khalifa, and Masud H. Chowdhury
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- 2017
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11. A new simple emulator circuit for current controlled memristor.
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Abdullah G. Alharbi, Zainulabideen J. Khalifa, Mohamed E. Fouda, and Masud H. Chowdhury
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- 2015
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12. Memristor emulator based on single CCII.
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Abdullah G. Alharbi, Zainulabideen J. Khalifa, Mohammed E. Fouda, and Masud H. Chowdhury
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- 2015
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13. Impact of radiotherapy on survival in resected or unresectable anaplastic thyroid carcinomas, a Rare Cancer Network study
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X S, Sun, J, Le Guevelou, J, Jacquemin, Y, Drouet, T S, Sio, G, Bar-Sela, C, Carrie, J-C, Faivre, J, Khalifa, C, Demiroz, H, Qiu, U, Schick, B, Atalar, N, Fakhry, L, Mengue, J, Pan, S, Servagi-Vernat, and J, Thariat
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Oncology ,Humans ,Radiotherapy, Adjuvant ,Radiology, Nuclear Medicine and imaging ,Chemoradiotherapy ,Thyroid Neoplasms ,Middle Aged ,Prognosis ,Thyroid Carcinoma, Anaplastic ,Retrospective Studies - Abstract
Anaplastic thyroid carcinomas (ATC) are a heterogenous group of tumors of overall dismal prognosis. We designed models to identify relevant prognostic factors of survival of irradiated ATC patients including radiotherapy modalities (field size, dose).Between 2000 and 2017, 166 ATC patients' treatments were divided into surgery and postoperative radiotherapy (poRT) or definitive radiotherapy (RT). Multiple imputation approach was used for missing data. Prognostic factors were identified using Lasso-penalized Cox modelling and predicted risk scores were built.Patients undergoing RT (n=70) had more adverse patient and disease characteristics than those undergoing poRT (n=96). Corresponding median survival rates were 5.4 and 12.1 months, respectively. PoRT patients undergoing poRT more likely received extended-field radiotherapy with prophylactic nodal irradiation, but rather received platinum- vs. adriamycin-based chemoradiotherapy. Radiotherapy was conventionally fractionated, delivered60Gy in 51.9% and 61.7% and used extended fields in 88.5% and 71.2% of patients with poRT or RT. Radiotherapy interruption rates for toxicity were similar in the two groups. The best poRT-group model identified age45yo, PS≥1, pathologic tumor stage≥pT4b,N1 and R2 resection as poor prognostic factors. The best RT-group model (C-index of 0.72) identified PS≥3,N1 and extended-field radiotherapy with prophylactic nodal irradiation (as opposed to tumour-bed irradiation only) as poor prognostic factors.In patients undergoing poRT, radiotherapy parameters had little influence over their survival irrespective of patient, disease characteristics, and quality of resection. In patients undergoing RT, extended-field radiotherapy improved survival in addition to PS and nodal stage.
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- 2022
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14. Radiotherapy for primary lung cancer
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J, Khalifa, D, Lerouge, C, Le Péchoux, N, Pourel, J, Darréon, F, Mornex, and P, Giraud
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Lung Neoplasms ,Radiotherapy ,Respiration ,Radiotherapy Dosage ,Small Cell Lung Carcinoma ,Tumor Burden ,Oncology ,Carcinoma, Non-Small-Cell Lung ,Radiation Oncology ,Humans ,Radiology, Nuclear Medicine and imaging ,Dose Fractionation, Radiation ,France ,Neoplasm Staging ,Radiotherapy, Image-Guided - Abstract
Herein are presented the recommendations from the Société française de radiothérapie oncologique regarding indications and modalities of lung cancer radiotherapy. The recommendations for delineation of the target volumes and organs at risk are detailed.
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- 2022
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15. RADIORYTHMIC: Phase III, Opened, Randomized Study of Postoperative Radiotherapy Versus Surveillance in Stage IIb/III of Masaoka Koga Thymoma after Complete Surgical Resection
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Xavier Quantin, Nicolas Girard, Marylise Ginoux, Luc Thiberville, Benjamin Besse, Christelle Clément-Duchêne, P.A. Thomas, P. Mordant, Angela Botticella, C. Le Pechoux, J. Khalifa, Eric Pichon, Thierry Jo Molina, F. Le Tinier, Youssef Oulkhouir, Mallorie Kerjouan, Clémence Basse, Pierre Emmanuel Falcoz, F. Thillays, Virginie Westeel, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), and Normandie Université (NU)
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Adult ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Cancer Research ,medicine.medical_specialty ,Thymoma ,Adolescent ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Network ,law.invention ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,hemic and lymphatic diseases ,medicine ,Clinical endpoint ,Humans ,Postoperative Period ,Postoperative radiotherapy ,Stage (cooking) ,Lung cancer ,Aged ,Neoplasm Staging ,Retrospective Studies ,Surveillance ,business.industry ,Mediastinum ,Retrospective cohort study ,Thymus Neoplasms ,Middle Aged ,Prognosis ,medicine.disease ,3. Good health ,Radiation therapy ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Surgery ,Radiology ,business - Abstract
Introduction Thymomas are rare intrathoracic malignancies that may be aggressive and difficult to treat. Knowledge and level of evidence for treatment strategies are mainly based on retrospective studies or expert opinion. Currently there is no strong evidence that postoperative radiotherapy after complete resection of localized thymoma is associated with survival benefit in patients. RADIORYTHMIC is a phase III, randomized trial aiming at comparing postoperative radiotherapy versus surveillance after complete resection of Masaoka-Koga stage IIb/III thymoma. Systematic central pathologic review will be performed before patient enrollment as per the RYTHMIC network pathway. Patients and Methods Three hundred fourteen patients will be included; randomization 1:1 will attribute either postoperative radiotherapy (50-54 Gy to the mediastinum using intensity-modulated radiation therapy or proton beam therapy) or surveillance. Stratification criteria include histologic grading (thymoma type A, AB, B1 vs B2, B3), stage, and delivery of preoperative chemotherapy. Patient recruitment will be mainly made through the French RYTHMIC network of 15 expert centers participating in a nationwide multidisciplinary tumor board. Follow-up will last 7 years. The primary endpoint is recurrence-free survival. Secondary objectives include overall survival, assessment of acute and late toxicities, and analysis of prognostic and predictive biomarkers. Results The first patient will be enrolled in January 2021, with results expected in 2028.
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- 2021
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16. Recommendations for stereotactic body radiation therapy for spine and non-spine bone metastases. A GETUG (French society of urological radiation oncolgists) consensus using a national two-round modified Delphi survey
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F, Vilotte, D, Pasquier, P, Blanchard, S, Supiot, J, Khalifa, U, Schick, T, Lacornerie, L, Vieillevigne, D, Marre, O, Chapet, I, Latorzeff, N, Magne, E, Meyer, K, Cao, Y, Belkacemi, J E, Bibault, M, Berge-Lefranc, J C, Faivre, K, Gnep, V, Guimas, A, Hasbini, J, Langrand-Escure, C, Hennequin, and P, Graff
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The relevance of metastasis-directed stereotactic body radiation therapy (SBRT) remains to be demonstrated through phase III trials. Multiple SBRT procedures have been published potentially resulting in a disparity of practices. Therefore, the french society of urological radiation oncolgists (GETUG) recognized the need for joint expert consensus guidelines for metastasis-directed SBRT in order to standardize practice in trials carried out by the group.After a comprehensive literature review, 97 recommendation statements were created regarding planning and delivery of spine bone (SBM) and non-spine bone metastases (NSBM) SBRT. These statements were then submitted to a national online two-round modified Delphi survey among main GETUG investigators. Consensus was achieved if a statement received ≥ 75 % agreements, a trend to consensus being defined as 65-74 % agreements. Any statement without consensus at round one was re-submitted in round two.Twenty-one out of 29 (72.4%) surveyed experts responded to both rounds. Seventy-five statements achieved consensus at round one leaving 22 statements needing a revote of which 16 achieved consensus and 5 a trend to consensus. The final rate of consensus was 91/97 (93.8%). Statements with no consensus concerned patient selection (3/19), dose and fractionation (1/11), prescription and dose objectives (1/9) and organs at risk delineation (1/15). The voting resulted in the writing of step-by-step consensus guidelines.Consensus guidelines for SBM and NSBM SBRT were agreed upon using a validated modified Delphi approach. These guidelines will be used as per-protocole recommendations in ongoing and further GETUG clinical trials.
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- 2022
17. [Bladder-sparing trimodal therapy for muscle invasive bladder cancer]
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J, Khalifa, M, Roumiguié, D, Pouessel, and P, Sargos
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Urinary Bladder Neoplasms ,Muscles ,Urinary Bladder ,Quality of Life ,Humans ,Neoplasm Invasiveness ,Cystectomy ,Combined Modality Therapy ,Organ Sparing Treatments - Abstract
Organ-sparing strategies in the management of local or locally advanced cancers meet a dual objective: tumor control and preservation of the function of the involved organ. Given the morbidity and mortality of cystectomy and its impact on quality of life and bladder function, bladder-sparing strategies have emerged for the management of urothelial muscle invasive bladder cancer, mostly through trimodal treatment, which consists in maximal trans-urethral resection of bladder tumor, followed by chemo-radiotherapy. This review presents the modalities of trimodal treatment, before exposing the advantages and limitations of this strategy compared to cystectomy among operable patients. Despite the absence of comparative data from randomized trials, the two approaches seem to provide similar oncological results among appropriately selected patients. In modern series, the rate of salvage cystectomy is approximately 15% at 5 years; this delayed cystectomy does not seem to be associated with greater morbidity and mortality as compared to upfront cystectomy. Emphasis is placed in the review on quality of life data of these two approaches. In order to optimize the selection of patients eligible to trimodal therapy, the classical predictive factors of response to radio(chemo)therapy are critically analyzed, with the perspective of innovative molecular biomarkers. Finally, a close multidisciplinary collaboration is needed for the choice and the execution of the therapeutic strategy, and the patient should be fully involved in the decision-making process.
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- 2022
18. Multimodality planning of stereotactic radio-ablation for ventricular tachycardia. Results from the international MUSIC consortium
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H Cochet, U Tedrow, P Maury, J Whitaker, C Woods, E Gandjbakhch, J Khalifa, J Bredfeldt, R Mak, W Sauer, M Sermesant, F Sacher, F Bogun, P Jais, and P Zei
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Research Council Background Optimal SBRT planning methods for VT ablation are yet to be defined. Purpose To evaluate a multimodal approach for SBRT planning. Methods 30 pts (age 70±10, 90% men, LVEF 26±9%, 67% ICM, 47% NICM or mixed, 1.7±1.2 prior catheter ablations) with drug-refractory VT underwent imaging prior to SBRT. The inHEART technology was used to create image-based 3D models of substrate, cardiac anatomy, and organs at risk (coronaries, phrenic nerve, GI tract, AV node). In MUSIC software (IHU Liryc-Inria), 3D models were fused with prior EP maps, and SBRT targets were interactively drawn in 3D by the referring EP cardiologist. Transmural target volumes and organs at risk were fused with a 4D planning CT and used to plan SBRT in Eclipse (Varian). Results SBRT was delivered on median PTVs of 96[63-149] mL (total dose 25 Gy) with either Truebeam or Edge systems (Varian). Over a median FU of 4[2-8] months, death occurred in 11(37%) pts, due to arrhythmia recurrence in 4(13%). FU at 6 months was available in 14 pts. In these, the median numbers of VT episodes and ICD shocks over the 6 months preceding SBRT were 20[9-27] and 8[5-15], respectively. In the 6 months following SBRT, these decreased to 0[0-30] and 0[0-0], respectively (P Conclusion In patients with severe drug- and catheter ablation-refractory VT, SBRT planning based on 3D image-based models fused with prior EP maps is feasible, and associated with favorable efficacy and safety profiles.
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- 2022
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19. Effect of increasing etching time on the efficiency of porous silicon solar cells
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Manal J Khalifa
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History ,Computer Science Applications ,Education - Abstract
In this work, p-type silicon wafers were electrochemically etched to create nanocrystalline silicon (porous silicon (PS)) films. Different etching periods (5, 10, 15, and 20 minutes) were investigated to see how they affected the development of a nanosized pore array with a constant etching current density (10 mA/cm2). To prevent oxidation, PS samples were stored in methanol after preparation. PS is characterized by X-ray diffraction (XRD), and atomic force microscopy (AFM). At varied etching times (5, 10, 15, and 20 min), the crystallite size as determined by XRD was equal to (66.39, 88.13, 31.2, and 21.21) nm, respectively. The nanometric size was verified via AFM. The porosity of PS increased as the etching time increased; the maximum value was obtained at a 20-minute etching time. The C-V characteristic of PS/Si heterojunction describes control factors like built-in potential (Vbi) and the kind of connection, a linear relationship of 1/C2 with bias voltage indicating that the junction is an abrupt type. Vbi was calculated for PS/p-Si/Al heterojunction at different etching times, and it was between (1.1-1.8) volt. I-V characteristics under illumination showed an enhancement in the efficiency of the PS/Si/Al solar cells. The maximum value of the solar cell efficiency was 6.79% occurs at 15 min time of etching.
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- 2023
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20. Dose-Response Effect and Dose-Toxicity in Stereotactic Radiotherapy for Brain Metastases: A Review
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Jean-Baptiste Clavier, J. Khalifa, Justine Attal Khalifa, Elisabeth Moyal, and Maxime Loo
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Cancer Research ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,radiosurgery ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Rate control ,Review ,Dose per fraction ,Radiosurgery ,Stereotactic radiotherapy ,Oncology ,Response effect ,brain metastases ,Toxicity ,Medicine ,stereotactic radiotherapy ,Radiology ,fractionation ,business ,Toxicity profile ,dose-effect relation ,RC254-282 ,Stereotactic irradiation - Abstract
Simple Summary Brain metastases are one of the most frequent complications for cancer patients. Stereotactic radiosurgery is considered a cornerstone treatment for patients with limited brain metastases and the ideal dose and fractionation schedule still remain unknown. The aim of this literature review is to discuss the dose-effect relation in brain metastases treated by stereotactic radiosurgery, accounting for fractionation and technical considerations. Abstract For more than two decades, stereotactic radiosurgery has been considered a cornerstone treatment for patients with limited brain metastases. Historically, radiosurgery in a single fraction has been the standard of care but recent technical advances have also enabled the delivery of hypofractionated stereotactic radiotherapy for dedicated situations. Only few studies have investigated the efficacy and toxicity profile of different hypofractionated schedules but, to date, the ideal dose and fractionation schedule still remains unknown. Moreover, the linear-quadratic model is being debated regarding high dose per fraction. Recent studies shown the radiation schedule is a critical factor in the immunomodulatory responses. The aim of this literature review was to discuss the dose–effect relation in brain metastases treated by stereotactic radiosurgery accounting for fractionation and technical considerations. Efficacy and toxicity data were analyzed in the light of recent published data. Only retrospective and heterogeneous data were available. We attempted to present the relevant data with caution. A BED10 of 40 to 50 Gy seems associated with a 12-month local control rate >70%. A BED10 of 50 to 60 Gy seems to achieve a 12-month local control rate at least of 80% at 12 months. In the brain metastases radiosurgery series, for single-fraction schedule, a V12 Gy < 5 to 10 cc was associated to 7.1–22.5% radionecrosis rate. For three-fractions schedule, V18 Gy < 26–30 cc, V21 Gy < 21 cc and V23 Gy < 5–7 cc were associated with about 0–14% radionecrosis rate. For five-fractions schedule, V30 Gy < 10–30 cc, V 28.8 Gy < 3–7 cc and V25 Gy < 16 cc were associated with about 2–14% symptomatic radionecrosis rate. There are still no prospective trials comparing radiosurgery to fractionated stereotactic irradiation.
- Published
- 2021
21. OC-0609 Radiotherapy quality assurance of the PEACE-1 trial: Initial results of individual case reviews
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N. Alyamani, P. Sargos, P. Blanchard, S. Supiot, P. Ronchin, P. Pommier, T. Duberge, M. Silva, Y. Hammoud, A. Hasbini, J. Khalifa, K. Gnep, C. Scrase, J. Saez, L. Vieillevigne, M. Christiaens, T. Zilli, H. Ribault, A. Bossi, K. Fizazi, and N. Andratschke
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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22. La radiothérapie stéréotaxique: indication et résultats dans les stades précoces
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J. Khalifa and C. Massabeau
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Pulmonary and Respiratory Medicine - Abstract
Resume La radiotherapie stereotaxique des lesions primitives pulmonaires est devenue le traitement de reference des CBNPC de stade precoce T1 T2a N0 chez les patients inoperables. Sa superiorite face a une radiotherapie classique a ete demontree dans l’essai randomise CHISEL, avec un taux de rechutes locales a 2 ans de 14 vs 31 %. Les resultats en terme de controle local > 80-90 % accompagnes de toxicites faibles dans les nombreuses series publiees et les essais prospectifs plaident pour l’expansion de ses indications, jusque-la plutot reservee aux patients fragiles et a haut risque operatoire. Le choix des doses et du fractionnement et la technique de radiotherapie stereotaxique doivent faire l’objet de reflexions tenant compte de la situation clinique du patient, des traitements anterieurs et de la tumeur a traiter (taille et topographie). Les traitements iteratifs, de rattrapage en cas d’echecs d’autres traitements locaux et les reirradiations offrent de nouvelles perspectives pour les patients, remplacant ou retardant l’utilisation d’un traitement systemique. Enfin, l’amelioration des connaissances sur les patterns de reponse sur l’imagerie scanographique et metabolique a contribue a securiser et fiabiliser le suivi des patients.
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- 2019
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23. Les cancers bronchiques non à petites cellules oligométastatiques: définition et prise en charge
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A. Desmet, L. Brouchet, C. Massabeau, J. Khalifa, and P. Van Houtte
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Pulmonary and Respiratory Medicine - Abstract
Resume Le concept de maladie oligometastatique est ne dans les annees 90 afin d’identifier une sous-population de patients dont la maladie metastatique presente une faible charge tumorale (essentiellement du fait d’un faible nombre de metastases , generalement inferieur a 5), et dont l’evolution est plutot indolente. Cette entite a permis de developper de nouvelles approches therapeutiques plus agressives pour ces patients, associant au classique traitement systemique, un traitement local ablatif des lesions secondaires et du primitif, base sur la chirurgie, la radiotherapie classique ou stereotaxique et la radiologie interventionnelle. Applique au cancer bronchique non a petites cellules, cette approche repose essentiellement sur deux essais prospectifs mais dont le niveau de preuve reste encore insuffisant pour la voir proposer comme standard de traitement. Par ailleurs, un des defis majeurs de cette approche consiste a identifier, sur des criteres cliniques, mais egalement biologiques a l’aide de signatures genomiques notamment, les patients oligometastatiques les plus susceptibles de beneficier de ces strategies therapeutiques agressives, afin de ne pas generer inutilement des toxicites des traitements locaux pouvant alterer la qualite de vie des patients.
- Published
- 2019
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24. Impact of Neck Dissection in Head and Neck Squamous Cell Carcinomas of Unknown Primary
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Jessica Miroir, Yungan Tao, M. Doré, Shakeel Sumodhee, Nicolas Blanchard, A. Beddok, Alexandre Coutte, Matthieu Caubet, C. Pflumio, Julia Salleron, Jean-Christophe Faivre, Juliette Thariat, S. Servagi-Vernat, Valentin Calugaru, Joël Castelli, X. Sun, I. Troussier, Paul Giraud, Vincent Roth, Bruno Toussaint, Marco Krengli, J. Khalifa, Duc Trung Nguyen, Claire Petit, Florent Carsuzaa, Yazan Abu-Shama, Lionel Geoffrois, Edouard Romano, Charles Dupin, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut Gustave Roussy (IGR), Département de radiothérapie [Gustave Roussy], Institut Curie [Paris], Institut Jean Godinot [Reims], Centre Eugène Marquis (CRLCC), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), Università degli Studi del Piemonte Orientale - Amedeo Avogadro (UPO), Service d'oncologie-radiothérapie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), Clinique des Dentellières [Valenciennes, France], CHU Amiens-Picardie, CHU Bordeaux [Bordeaux], Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Easy Global Market [Sophia-Antipolis], Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), and UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)
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Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Urology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Article ,Chemoradiotherapy ,Head and neck ,Neck dissection ,Neoplasms/cancers/carcinomas ,Prognosis ,Unknown primary ,chemoradiotherapy ,head and neck ,03 medical and health sciences ,0302 clinical medicine ,neoplasms/cancers/carcinomas ,medicine ,Stage (cooking) ,030223 otorhinolaryngology ,neck dissection ,RC254-282 ,Chemotherapy ,business.industry ,Incidence (epidemiology) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,unknown primary ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Lymphadenectomy ,prognosis ,business ,Adenectomy - Abstract
International audience; Simple Summary: A retrospective multicentric study of 322 patients with head and neck cancers of unknown primary (HNCUP) was performed testing the impact of neck dissection (ND) extent on nodal relapse, progression-free survival and survival. After 5 years, the incidence of nodal relapse was 13.4%, and progression-free survival (PFS) was 59.1%. In multivariate analysis after adjusting for nodal stage, the risk of nodal relapse or progression was reduced with lymphadenectomy, selective ND or radical/modified ND but survival rates were similar. Patients undergoing lymphadenectomy or ND had significantly better PFS and a lower nodal relapse incidence in the N1 + N2a group, but the improvement was not significant for the N2b or N2 + N3c patients. Severe toxicity rates exceeded 40% with radical ND. In HNCUP, ND improves PFS regardless of nodal stage but fails to improve survival. The magnitude of the benefit of ND did not appear to depend on ND extent and decreased with a more advanced nodal stage.Abstract: Purpose: Management of head and neck cancers of unknown primary (HNCUP) combines neck dissection (ND) and radiotherapy, with or without chemotherapy. The prognostic value of ND has hardly been studied in HNCUP.Methods: A retrospective multicentric study assessed the impact of ND extent (adenectomy, selective ND, radical/radical-modified ND) on nodal relapse, progression-free survival (PFS) or survival, taking into account nodal stage. Results: 53 patients (16.5%) had no ND, 33 (10.2%) had lymphadenectomy, 116 (36.0%) underwent selective ND and 120 underwent radical/radical-modified ND (37.3%), 15 of which received radical ND (4.7%). With a 34-month median follow-up, the 3-year incidence of nodal relapse was 12.5% and progression-free survival (PFS) 69.1%. In multivariate analysis after adjusting for nodal stage, the risk of nodal relapse or progression was reduced with lymphadenectomy, selective or radical/modified ND, but survival rates were similar. Patients undergoing lymphadenectomy or ND had a better PFS and lowered nodal relapse incidence in the N1 + N2a group, but the improvement was not significant for the N2b or N2 + N3c patients. Severe toxicity rates exceeded 40% with radical ND. Conclusion: In HNCUP, ND improves PFS, regardless of nodal stage. The magnitude of the benefit of ND does not appear to depend on ND extent and decreases with a more advanced nodal stage
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- 2021
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25. [A review of adaptive radiotherapy for bladder cancer]
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M, Cabaillé, J, Khalifa, A M, Tessier, S, Belhomme, G, Créhange, and P, Sargos
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Organs at Risk ,Urinary Bladder Neoplasms ,Radiotherapy Planning, Computer-Assisted ,Feasibility Studies ,Humans ,Organ Motion ,Radiotherapy, Intensity-Modulated ,Radiation Injuries ,Radiotherapy, Image-Guided - Abstract
Radiation therapy (RT) for muscle invasive bladder cancer (MIBC) is challenging, with observed variations in bladder shape and size resulting in inappropriate coverage of the target volumes (CTV). Large margins were historically applied around the CTV, increasing the dose delivered to organs at risk (OAR). With repositioning imaging and visualization of soft tissues during image guided RT, an opportunity to consider these movements and deformations appeared possible with an adaptive RT approach (ART).A bibliographic search on the PubMed database has been done in January 2019. Studies focusing on patients with MIBC, treating on ART, with the objectives of feasibility, clinical and/or dosimetric evaluation and comparison with a standard irradiation technique were eligible. The purpose of this review was to define the different ART techniques used in clinical practice, to discuss their advantages compared to conventional RT in terms of target volume's coverage and OAR dose and to describe their feasibility in clinical practice.A total of 30 studies were selected. The strategies known as "composite offline", "plan of the day" not individualized or individualized, and "re-optimization" have been identified. All the studies have shown a significant benefit of ART in target coverage and dose of OAR, especially the rectum and small bowel. All ART plans produced are not used during RT sessions. Inter-observer variability for the selection of these plans can be observed. The practical implementation within a department required staff education and training, and increases the duration of treatment preparation. The "A-POLO" approach seems to be the most suitable for practice.ART is the technique of choice for bladder cancer RT. The "plan of the day" approach, individualized according to the A-POLO methodology, seems to be the most effective. The emergence of daily re-optimization, especially using MRI-Linac, is promising. The correlation between dosimetric benefits and clinical efficacy and safety results should be demonstrated into future trials.
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- 2020
26. PO-1272 SBRT for oligoprogressive/oligorecurrent SCLC: is it worth it?
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A. Levy, A. Botticella, E. Cohen-Jonathan Moyal, C. Massabeau, C. Le Péchoux, and J. Khalifa
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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27. In Regard to Marcq et al
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J. Khalifa and P. Sargos
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Cancer Research ,Radiation ,Oncology ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Humanities - Published
- 2021
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28. Quality of Life among Surgical Residents at King Abdulaziz Medical City in Jeddah, Saudi Arabia
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Mohammed J Khalifa, Malik M Almailabi, Zaher Abdulaziz Mikwar, Atheel Balkhy, Rakan S. Alajmi, and Muhammad Anwar Khan
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Quality of life ,medicine.medical_specialty ,education ,Specialty ,lcsh:Medicine ,030209 endocrinology & metabolism ,Burnout ,Stress ,Occupational safety and health ,03 medical and health sciences ,0302 clinical medicine ,Surgical residents ,Medicine ,030212 general & internal medicine ,Response rate (survey) ,business.industry ,Significant difference ,lcsh:R ,General Medicine ,Family medicine ,Marital status ,Job satisfaction ,Public Health ,business - Abstract
BACKGROUND: Surgical residency program is considered one of the toughest residency programs, which affects quality of life of the residents during training years. To date, no study has evaluated quality of life among residents, especially surgical residents here in Saudi Arabia. AIM: The objective of this study is to evaluate quality of life among surgical residents. METHODS: The study is a cross-sectional study conducted during September 2018 in King Khalid Hospital at King Abdulaziz Medical City (KAMC) Jeddah, Saudi Arabia. The study utilized the Work-Related Quality of Life, WRQoL, scale which measures perceived quality of life covering six domains: General Well-Being (GWB), Home-Work Interface (HWI), Job and Career Satisfaction (JCS), Control at Work (CAW), Working Conditions (WCS) and Stress at Work (SAW), in addition to demographic questions, asking about (age, gender, marital status, resident level, specialty, BMI, smoking, number of days of exercise per week, hours of sleep per day, on-calls per month, clinics per week, operations per week). RESULTS: Of the 99 surgical residents training at KAMC, 73 residents returned the survey with a response rate of 72.8%. The mean age of the residents was 28 ± 2.1 years with the mean BMI of 25 kg/m2. 54.8% were married, and 42.5% were smokers. Half of the residents (50.7%) working in King Abdulaziz Medical City have low work-related quality of life. In comparison between male and female residents’ overall Quality of life, there was no significant difference between them (p = 0.363). CONCLUSIONS: Our main study finding is that half of the residents (50.7%) working at KAMC has low work-related quality of life, and there is no significant difference between male and female residents. Further studies are needed to determine the causes and improve the work-related quality of life among surgical residents.
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- 2019
29. 10-Year Locoregional Control with Postoperative External Beam Radiotherapy in Patients with Locally Advanced High-Risk Non-Anaplastic Thyroid Carcinoma De Novo or at Relapse, a Propensity Score Analysis
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Julia Salleron, Gil Bar-Sela, Jianji Pan, Terence T. Sio, Stéphanie Servagi Vernat, Juliette Thariat, Jean-Christophe Faivre, J. Khalifa, Emmanuel Kammerer, Hao Qiu, Jean-Marc Simon, X. Sun, and E. Blais
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Cancer Research ,medicine.medical_specialty ,non-anaplastic ,medicine.medical_treatment ,Locally advanced ,Perineural invasion ,030209 endocrinology & metabolism ,lcsh:RC254-282 ,Article ,Thyroid carcinoma ,surgery ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Cumulative incidence ,External beam radiotherapy ,radiotherapy ,business.industry ,Hazard ratio ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,thyroid carcinoma ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,locoregional failure ,Propensity score matching ,Radiology ,business - Abstract
(1) Background: To assess the role of postoperative external beam radiotherapy (pEBRT) on locoregional failure (LRF) for patients with locally advanced high-risk non-anaplastic thyroid carcinoma (naTC) at primary event or relapse. (2) Methods: Between 1995 and 2015, postoperative naTC patients with a theoretical indication for EBRT were included based on criteria that were common to American-British-French current guidelines, i.e., pT3-4, pN+, gross or microscopic residual disease. Inverse probability of treatment weighting (IPTW) after multiple imputation was used to reduce selection biases. (3) Results: Of 254 naTC patients, 216 patients underwent pEBRT (106 de novo, 110 at relapse, median dose 60 Gy) and 38 underwent surgery only. pEBRT patients had more gross residual disease, a major prognostic factor (p = 0.027) but less perineural invasion (p = 0.008) or lymphovascular emboli (p = 0.009). pEBRT patients more frequently underwent radioiodine therapy (p = 0.026). The 10-year cumulative incidence of LRF was 56% (95% CI, 32&ndash, 74%) in operated patients, and 23% (95% CI, 17&ndash, 30%) in pEBRT patients. After IPTW method, pEBRT reduced the risk of LRF (hazard ratio 0.30, 95% CI [0.18&ndash, 0.49], p <, 0.001), but had no impact on OS. In the pEBRT group, non-Intensity Modulated RadioTherapy (IMRT) plans and interruption of the radiotherapy were associated with poorer survival, while extended versus limited field strategy and dose were not. (4) Conclusions: In naTC patients who have pT3-4, pN+ disease or R1-2 resection, pEBRT improved LRF. Limited-field IMRT is preferred.
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- 2019
30. Unilateral or bilateral irradiation in cervical lymph node metastases of unknown primary? A retrospective cohort study
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J. Khalifa, C. Pflumio, Shakeel Sumodhee, Matthieu Caubet, Ludivine Catteau, Xu Shan Sun, Amel Rehailia-Blanchard, A. Beddok, Vincent Roth, I. Troussier, Joël Castelli, Marco Krengli, Charles Dupin, Nicolas Blanchard, Valentin Calugaru, Jean-Christophe Faivre, Yoann Pointreau, Juliette Thariat, Julia Salleron, Jessica Miroir, Mélanie Doré, Edouard Romano, Paul Giraud, Samir H. Patel, S. Servagi-Vernat, Alexandre Coutte, René-Jean Bensadoun, Claire Petit, Lionnel Geoffrois, Yungan Tao, Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, Hôpital Nord Franche-Comté [Hôpital de Trévenans] (HNFC), Institut Gustave Roussy (IGR), Service de Radiothérapie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut Jean Godinot [Reims], CRLCC Eugène Marquis (CRLCC), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), CHU Amiens-Picardie, Service d'Oncologie radiothérapie [Clinique Victor Hugo], Clinique Victor Hugo [Le Mans], Mayo Clinic, CHU Saint-Etienne, Centre hospitalier universitaire de Poitiers (CHU Poitiers), EASY CRF : la recherche clinique en ligne, and ARCHADE (Advanced Resource Centre for HADrontherapy in Europe)
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Male ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Neck dissection ,Head and neck neoplasms ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cervical lymphadenopathy ,Neoplasms ,Chemotherapy ,Radiotherapy ,Unknown primary ,Carcinoma ,Humans ,Medicine ,Cumulative incidence ,Lymph node ,Aged ,Retrospective Studies ,Squamous Cell Carcinoma of Head and Neck ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Radiation therapy ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Concomitant ,Neoplasms, Unknown Primary ,Female ,Lymph Nodes ,medicine.symptom ,business - Abstract
Patients with cervical lymphadenopathy of unknown primary carcinoma (CUP) usually undergo neck dissection and irradiation. There is an ongoing controversy regarding the extent of nodal and mucosal volumes to be irradiated. We assessed outcomes after bilateral or unilateral nodal irradiation.This retrospective multicentre study included patients with CUP and squamous cellular carcinoma who underwent radiotherapy (RT) between 2000 and 2015.Of 350 patients, 74.5% had unilateral disease and 25.5% had bilateral disease. Of 297 patients with available data on disease and irradiation sides, 61 (20.5%) patients had unilateral disease and unilateral irradiation, 155 (52.2%), unilateral disease and bilateral irradiation and 81 (27.3%), bilateral disease and bilateral irradiation. Thirty-four (9.7%) and 217 (62.0%) patients received neoadjuvant and/or concomitant chemotherapy, respectively. Median follow-up was 37 months. Three-year local, regional, locoregional failure rates and CUP-specific survival were 5.6%, 11.7%, 15.0% and 84.7%, respectively. In patients with unilateral disease, the 3-year cumulative incidence of regional/local relapse was 7.7%/4.3% after bilateral irradiation versus 16.9%/11.1% after unilateral irradiation (hazard ratio = 0.56/0.61, p = 0.17/0.32). The cumulative incidence of CUP-specific deaths was 9.2% after bilateral irradiation and 15.5% after unilateral irradiation (p = 0.92). In multivariate analysis, mucosal irradiation was associated with better local control, whereas no neck dissection, ≥N2b and interruption of RT for more than 4 days were associated with poorer regional control. Toxicity was higher after bilateral irradiation (p 0.05). No positron-emission tomography-computed tomography, largest node diameter, ≥N2b, neoadjuvant chemotherapy and interruption of RT were associated with poorer cause-specific survival.Bilateral nodal irradiation yielded non-significant better nodal and mucosal control rates but was associated with higher rates of severe toxicity.
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- 2019
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31. 1742TiP RADIORYTHMIC: Phase III, opened, randomized study of post-operative radiotherapy (PORT) versus surveillance in stage IIb/III of Masaoka Koga thymoma after complete surgical resection
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Benjamin Besse, Eric Pichon, Fabien Calcagno, F. Thillays, Clémence Basse, Eric Dansin, Xavier Quantin, F. Le Tinier, P.A. Thomas, J. Khalifa, Youssef Oulkhouir, Mallorie Kerjouan, Luc Thiberville, C. Le Pechoux, Nicolas Girard, Christelle Clément-Duchêne, P-E. Falcoz, J. Mazieres, Angela Botticella, and Thierry Jo Molina
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Surgical resection ,medicine.medical_specialty ,Thymoma ,business.industry ,Hematology ,medicine.disease ,Post operative radiotherapy ,Surgery ,law.invention ,Port (medical) ,Oncology ,Randomized controlled trial ,law ,medicine ,Stage iib ,business - Published
- 2021
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32. Al2O3 NPs/porous silicon/silicon photovoltaic device
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A. N. Abd, M. J. Khalifa, and M. H. Jaduaa
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History ,Materials science ,Silicon ,chemistry ,business.industry ,Photovoltaic system ,chemistry.chemical_element ,Optoelectronics ,Porous silicon ,business ,Computer Science Applications ,Education - Abstract
Alumina nanoparticles or (Al2O3 NPs) have been prepared by electrolysis method and deposited using drop casting method on glass and porous silicon (PS) substrates as thin films. Electrochemical etching of p-type silicon wafers was used to prepare nanocrystalline porous silicon. The structural and morphological properties of Al2O3 NPs were investigated by XRD, AFM and SEM techniques, respectively. The optical energy band gap of Al2O3 nanostructure (NSs) has been determined from its optical properties and it was around 3.6 eV. TEM has been used to investigate the nanoscale morphology of Al2O3NPs and showed the grains had a spherical shape and it confirmed the nanometric size of the prepared NPs. PS’s XRD pattern revealed that it had a single crystalline structure, whereas it was amorphous for the Al2O3 NSs. The nanometric scale of both Al2O3 NSs and PS was calculated by XRD patterns, it was about 34nm for Al2O3 NPs and about 90 nm for PS. The diffusion effect of the Al2O3NPs on the electrical properties of heterojunctions PS/Si was studied. Photovoltaic characteristics have been reported for Al2O3NPs/PS/Si Photovoltaic device. Ag/Al2O3/PS/Si/Al solar cell parameters were reported the efficiency of solar cell was 11.8% and F.F is 32.08 %. Ag/Al2O3/PS/Si/Al Photodetector heterojunctions have two peaks of response the first one located at 350 nm and the second at 850 nm with maximum responsivity of 0.8A/W.
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- 2021
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33. Traitements locaux : indication et résultats dans les stades précoces
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J. Khalifa, J.-Y. Gaubert, L. Padovani, C. Massabeau, and P. Habert
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Pulmonary and Respiratory Medicine - Abstract
Resume La lobectomie avec curage ganglionnaire radical reste le traitement de reference du cancer pulmonaire primitif non a petites cellules (NSCLC) de stade I. L’evolution spontanee des tumeurs pulmonaires NSCLC etant tres pejorative, le recours aux traitements locaux non chirurgicaux est une option precieuse pour la prise en charge de ces patients fragiles et non eligibles a une chirurgie. Au cours des dernieres annees, la radiotherapie stereotaxique (SBRT) et les techniques d’ablation percutanee (ou destruction tumorale percutanee) ont progressivement pris toute leur place dans cette indication. Le choix des doses et du fractionnement et de la technique de traitement doivent faire l’objet de reflexions tenant compte de la situation clinique du patient, des traitements anterieurs et de la tumeur a traiter (taille et topographie). Les traitements iteratifs, de rattrapage en cas d’echecs d’une des techniques et les reirradiations offrent de nouvelles perspectives pour les patients, remplacant ou retardant l’utilisation d’un traitement systemique. Enfin, l’interpretation de l’imagerie scanographique et metabolique de suivi s’ameliore continuellement meme si elle reste encore aujourd’hui tres difficile. © 2020 SPLF. Publie par Elsevier Masson SAS. Tous droits reserves.
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- 2020
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34. Prise en charge des cancers bronchiques non à petites cellules oligométastatiques
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A. Desmet, F. Le Tinier, J. Khalifa, C. Massabeau, P. Van Houtte, E. Dansin, and L. Brouchet
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Pulmonary and Respiratory Medicine - Abstract
Resume La notion de maladie oligometastatique s’applique a une sous-population de patients presentant une faible charge tumorale caracterisee sur le plan clinique par un nombre limite de metastases. La 8e classification TNM differentie ce sous-groupe de patients atteints d’une seule metastase extra-thoracique (stade M1b) des patients presentant plusieurs metastases extrathoraciques dans un ou plusieurs organes (stade M1c). Ces stades oligometastatiques peuvent relever d’approches therapeutiques renforcees combinant traitement systemique et traitement local des lesions secondaires et du primitif bronchique, par la chirurgie, la radiotherapie conventionnelle ou stereotaxique et la radiologie interventionnelle. L’immunotherapie combinee a la radiotherapie est egalement en cours d’evaluation dans cette situation clinique particuliere. L’identification des patients candidats a de telles strategies therapeutiques demeure toutefois difficile puisqu’il ne s’agit pas de surajouter des toxicites a une absence de benefice clinique significatif. A cote des facteurs pronostiques cliniques (PS, stade N, chronologie de survenue et/ou site des metastases…), la determination de biomarqueurs predictifs (micro-ARN, signatures genomiques, statut PDL1…) serait utile a une prise en charge optimisee des patients oligometastatiques. © 2020 SPLF. Publie par Elsevier Masson SAS. Tous droits reserves.
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- 2020
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35. [Image-guided radiotherapy in lung cancer]
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A, Aboudaram, J, Khalifa, C, Massabeau, L, Simon, A, Hadj Henni, and S, Thureau
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Lung Neoplasms ,Radiotherapy Planning, Computer-Assisted ,Respiration ,Humans ,Radiotherapy, Image-Guided - Abstract
Image-guided radiotherapy takes place at every step of the treatment in lung cancer, from treatment planning, with fusion imaging, to daily in-room repositioning. Managing tumoral and surrounding thoracic structures motion has been allowed since the routine use of 4D computed tomography (4DCT). The integration of respiratory motion has been made with "passive" techniques based on reconstruction images from 4DCT planning, or "active" techniques adapted to the patient's breathing. Daily repositioning is based on regular images, weekly or daily, low (kV) or high (MV) energy. MRI and functional imaging also play an important part in lung cancer radiation and open the way for adaptative radiotherapy.
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- 2018
36. Place de l’arcthérapie modulée et de la chimiothérapie concomitante dans la prise en charge des cancers du canal anal localement évolués
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Pascal Fenoglietto, Catherine Dejean, C. Benahim, S. Servagi-Vernat, S. Vieillot, I. Troussier, Florence Huguet, René-Jean Bensadoun, Cécile Ortholan, Juliette Thariat, I. Darmon, L. Krebs, and J. Khalifa
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Gynecology ,medicine.medical_specialty ,Oncology ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,business ,Volumetric modulated arc therapy - Abstract
Resume Le traitement de reference des carcinomes epidermoides du canal anal localement evolues (stades II et III) est la chimioradiotherapie exclusive. Celle-ci delivre une dose de 45 Gy a raison de cinq fractions de 1,8 Gy par semaine dans un volume pelvien, puis un complement de dose de 14 a 20 Gy dans la tumeur. La chimiotherapie concomitante la plus souvent utilisee comprend une association de 5-fluoro-uracile et de mitomycine-C delivree lors de la premiere et cinquieme semaine d’irradiation. Une couverture optimale des volumes cibles est parfois difficile a obtenir avec une irradiation conformationnelle (jonctions des faisceaux, combinaison d’electrons et photons parfois complexes dans les aires ganglionnaires). La toxicite cutaneomuqueuse et digestive induite par le traitement peut necessiter un intervalle libre avant la realisation du complement d’irradiation. Celui-ci peut avoir un effet deletere sur les resultats s’il est prolonge (plus de 38 jours). Les differentes techniques de radiotherapie conformationnelle avec modulation d’intensite (statique segmentee, dynamique, arctherapie volumique modulee et tomotherapie helicoidale) ont leur interet dans cette localisation. Elles permettent d’obtenir une sterilisation tumorale et ganglionnaire avec une baisse des doses intermediaires et elevees aux organes a risque (intestin grele, perinee/organes genitaux, vessie, moelle osseuse) entrainant une reduction de la toxicite aigue de grade 3 ou plus ainsi qu’une meilleure conservation fonctionnelle du sphincter anorectal. Une description de la realisation de l’arctherapie volumique modulee est presentee dans cet article. Les avantages et inconvenients de cette technique par rapport aux autres y sont discutes.
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- 2015
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37. Uni or bilateral Irradiation in Cervical Lymph Node Metastases of Unknown Primary?
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Xu Shan Sun, Y. Pointreau, Joël Castelli, S.V. Stephanie, J. Miroir, Valentin Calugaru, I. Troussier, B. Arnaud, Yungan Tao, Claire Petit, Alexandre Coutte, A. rehalia-Blanchard, Marco Krengli, C. Pflumio, C. Dupin, L. Catteau, Vincent Roth, F. jean Christophe, M. Doré, Samir H. Patel, Shakeel Sumodhee, René-Jean Bensadoun, Juliette Thariat, N. Blanchard, J. Khalifa, P. Giraud, and Julia Salleron
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Cancer Research ,medicine.medical_specialty ,Radiation ,medicine.anatomical_structure ,Oncology ,business.industry ,medicine ,Unknown primary ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Lymph node - Published
- 2018
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38. Irradiation uni- ou bilatérale des métastases ganglionnaires cervicales de cancer primitif inconnu ?
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A. Rehailia-Blanchard, M. Caubet, S. Servagi Vernat, J. Khalifa, Julia Salleron, Joël Castelli, I. Troussier, Yungan Tao, C. Dupin, X. Sun, M. Doré, S. Sumodhee, Valentin Calugaru, Alexandre Coutte, A. Beddock, Yoann Pointreau, P. Giraud, L. Catteau, Vincent Roth, Claire Petit, Jean-Christophe Faivre, J. Miroir, C. Pflumio, René-Jean Bensadoun, Juliette Thariat, and N. Blanchard
- Subjects
Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectif de l’etude Les adenopathies cervicales du carcinome primaire inconnu divisent la communaute medicale entre ceux qui favorisent l’irradiation elective unilaterale et ceux qui preconisent l’irradiation bilaterale du cou. Nous voulions evaluer les controles locaux et regionaux et la toxicite apres irradiation cervicale bilaterale ou unilaterale. Materiel et methode Il s’agit d’une etude de cohorte multicentrique retrospective. Les patients atteints de carcinome primaire inconnu sans metastases distantes traites par une irradiation externe entre 2000 et 2015 ont ete inclus. Les patients ont fait l’objet d’un suivi regulier. Resultats Sur les 350 patients de 20 centres selectionnes, 39 (11,5 %) etaient atteints d’un cancer de stade N1, 70 (20,7 %) N2a, 117 (34,5 %) N2b, 24 (7,1 %) N2c et 89 (26,3 %) N3, 222 (70,9 %) d’un ou de plusieurs ganglion(s) en rupture capsulaire, 259 (74,4 %) patients ont eu un curage cervical, 350 (100 %) une irradiation cervicale, dont 61 (17,4 %) unilaterale et 304 (87,6 %) une irradiation des muqueuses. Trente-quatre (9,8 %) et 217 (62,2 %) patients ont ete pris en charge par chimiotherapie respectivement neoadjuvante et concomitante. Le suivi median etait de 37 mois (Ecart interquartile : 24 ; 63). Sur 3 ans, les taux de rechute locale, regionale et locoregionale etaient respectivement de 5,6 % [3,0–8,1], 11,7 % [8,1–15,2] et 15,0 % [10,9–18,8]. Les probabilites de survie globale sur trois ans et de survie specifique etaient respectivement de 80,6 % [75,5–84,8] et 84,7 % [80,6–89,1]. Dans l’analyse multifactorielle, 1) l’irradiation des muqueuses etait le seul facteur pronostique associe a un meilleur taux de controle local ; 2) la dissection du cou, le stade ≥ N2b et l’interruption de la radiotherapie de ≥ 4 jours etaient associes a un moins bon taux de controle regional ; et 3), la TEP-scanographie, le plus grand diametre N, le stade ≥ N2b, l’interruption de la radiotherapie et la chimiotherapie neoadjuvante ont ete associes a une survie specifique plus courte. Conclusion L’irradiation bilaterale semble etre plus efficace sur le controle des tumeurs mais notre etude manque de puissance.
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- 2018
- Full Text
- View/download PDF
39. Radiothérapie conformationnelle prostatique : quelles marges ?
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Frederic Commandeur, R. de Crevoisier, J. Khalifa, and J.M. Bachaud
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Prostatectomy ,business.industry ,medicine.medical_treatment ,Planning target volume ,Rectum ,Cancer ,medicine.disease ,medicine.anatomical_structure ,Oncology ,Prostate ,medicine ,Cooperative group ,Radiology, Nuclear Medicine and imaging ,Good prognosis ,Nuclear medicine ,business ,Image-guided radiation therapy - Abstract
The planning CT allows the delineation of the prostate (clinical target volume, CTV) but with an imprecision at the apex and the inability to visualize the intraprostatic cancer. MRI enables accurate visualization of the prostate outlines and in some extent the intraprostatic tumour (gross tumour volume [GTV]). The integration of MRI data within the CT remains still complex. Analysis of prostatectomy specimen has guided the definition of a CTV beyond the capsule, depending on pretreatment factors. In practice, the CTV can be defined as follows: prostate-only, for good prognosis tumours; prostate (+0 to 5mm margins, excluding the rectum) and seminal vesicles (possibly limited to 2 cm of their proximal region) for intermediate-risk tumours; prostate (+5mm margins) and seminal vesicles for high-risk tumours. The planning target volume (PTV) should be between 5mm and 10mm depending on the space directions, in the absence of image-guidance (IGRT). It could be reduced to 5mm in case of IGRT. In the adjuvant setting after prostatectomy, the definition of the CTV should follow the recommendations from cooperative groups. It takes into account both the analysis of pattern of local recurrence after prostatectomy, but also the specific histological analysis of the surgical specimen of the patient. The corresponding PTV margin is 6 to 8mm.
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- 2013
- Full Text
- View/download PDF
40. Impact de la radiothérapie orbitaire sur les résultats de la décompression chirurgicale chez 136 patients atteints d’orbitopathie dysthyroïdienne
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P. Imbert, C. Dekeister, L. Boulanouar, F. Boutault, J. Khalifa, Solange Grunenwald, and P. Caron
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,General Medicine - Abstract
Introduction L’orbitopathie dysthyroidienne (OD) debute par une phase inflammatoire, suivie d’une installation progressive de fibrose pour aboutir a une phase sequellaire. En cas d’OD moderee a severe en phase inflammatoire, une radiotherapie peut etre envisagee. En phase sequellaire, une decompression orbitaire chirurgicale peut s’averer necessaire s’il existe une gene fonctionnelle ou esthetique. Objectif Determiner l’eventuel impact de la radiotherapie orbitaire sur les resultats de la decompression orbitaire bilaterale en phase sequellaire. Le critere primaire de l’etude etait le gain obtenu sur l’exophtalmie apres chirurgie. Patients et methodes Il s’agit d’une etude observationnelle retrospective, exposes/non exposes selon que les patients avaient beneficie ou non d’une radiotherapie orbitaire avant une chirurgie de decompression. Trente-huit patients avaient recu une radiotherapie (RT+) et 98 n’en avaient pas recu (RT−), entre 1995 et 2016. Resultats Dans le groupe RT+ compare au groupe RT−, il y avait significativement plus d’hommes (29 % versus 12 %, p Conclusion Chez les patients ayant une OD, il n’y a pas d’effet deletere de la radiotherapie orbitaire sur les resultats de la decompression chirurgicale.
- Published
- 2017
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41. Impact de la radiothérapie sur le contrôle locorégional en analyse multifactorielle dans les cancers différenciés de la thyroïde opérés de pronostic défavorable
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P. Jianji, Julia Salleron, J. Khalifa, X. Sun, E. Blais, Gil Bar-Sela, Jean-Christophe Faivre, Q. Hao, S. Servagi-Vernat, Juliette Thariat, T.T. Sio, and Emmanuel Kammerer
- Subjects
Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectif de l’etude Cette etude retrospective nationale a evalue l’apport de la radiotherapie postoperatoire dans les carcinomes thyroidiens differencies de pronostic defavorable. Materiel et methode Les patients etaient eligibles sur ces criteres : carcinomes thyroidiens differencies de stade T3 ou T4, et/ou avec envahissement ganglionnaire avec rupture capsulaire, et/ou en recidive locoregionale, et/ou ne fixant pas l’iode. L’impact de la radiotherapie sur la recidive locoregionale a ete evaluee par un modele de Fine et Gray de maniere a prendre en compte le deces et la recidive metastatique comme evenements competitifs. Des facteurs pronostiques de recidive locoregionale ont ete recherches dans le sous-groupe des patients irradies. Resultats Au total, 254 patients (de 18 centres) ont ete inclus, dont 38 operes non irradies. Le suivi median etait de 78 mois. Les incidences cumulees de recidive locoregionale etaient respectivement a 5 et 10 ans de 18,6 % et 28,1 %. Les probabilites de survie globale a 5 et 10 ans etaient de 78,4 % et 63,0 %. Apres ajustement sur les facteurs de confusion potentiels, la radiotherapie diminuait le risque de recidive locoregionale avec un hazard ratio (HR) de 0,26 et un intervalle de confiance (IC) a 95 % de [0,13 ; 0,54]. A 10 ans, l’incidence cumule de recidive locoregionale etait de 23 % [17 % ; 30 %] pour les patients irradies contre 56 % [32 % ; 74 %] pour les patients non irradies. Apres ajustement sur les facteurs de confusion, la radiotherapie n’apportait pas de benefice de survie globale (HR : 0,82 ; IC95 % : 0,41–1,64). Parmi les patients irradies, la thyroidectomie totale diminuait le risque de recidive locoregionale alors que l’histologie insulaire le majorait. Conclusion La radiotherapie postoperatoire permet d’ameliorer le taux de controle locoregional dans les carcinomes thyroidiens differencies de pronostic defavorable.
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- 2018
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42. Identification of a candidate biomarker from perfusion MRI to anticipate glioblastoma progression after chemoradiation
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Georges Noël, E. Cohen Jonathan Moyal, Danielle Ibarrola, Isabelle Berry, J. Khalifa, Nicolas Magné, Marie-Pierre Sunyach, Paul Walker, M. Charissoux, Gilles Truc, I. Catalaa, Anne Laprie, Léonor Chaltiel, F. Tensaouti, S. Ken, Patrice Péran, Jean-Albert Lotterie, Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Dept Radiat Oncol, Institut Claudius Regaud, CRLCC Institut Claudius Regaud, Dept Biostatistiques, Département Médecine nucléaire, CHU Rangueil, CHU Rangueil, Service de Radiologie [Rangueil / Larrey], CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Centre Léon Bérard [Lyon], Centre d'Exploration et de Recherche Médicales par Émission de Positons (CERMEP), Université Joseph Fourier - Grenoble 1 (UJF)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Radiations Oncologie, Centre Paul Strauss, Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Département de Radiation oncologie, CGFL, Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Institut de Cancérologie Lucien Neuwirth, CHU Saint-Etienne, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Institut Claudius Regaud, Service de Médecine Nucléaire [Toulouse], Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Male ,Pathology ,Imaging biomarker ,Cerebral Blood-Volume ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,medicine.medical_treatment ,Contrast Media ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Adc Histogram Analysis ,Prospective Studies ,Prospective cohort study ,Blood Volume ,medicine.diagnostic_test ,Brain Neoplasms ,rCBV ,General Medicine ,Chemoradiotherapy ,Middle Aged ,Magnetic Resonance Imaging ,3. Good health ,030220 oncology & carcinogenesis ,Disease Progression ,Biomarker (medicine) ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Female ,Radiology ,Perfusion ,Perfusion weighted magnetic resonance imaging ,Bevacizumab Treatment ,Adult ,medicine.medical_specialty ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Apparent Diffusion-Coefficient ,03 medical and health sciences ,Contrast-Enhanced Mr ,Radiation-Injury ,medicine ,Effective diffusion coefficient ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Radiotherapy ,business.industry ,Surrogate endpoint ,High-Grade Gliomas ,Magnetic resonance imaging ,Biomarker ,Imaging Biomarker ,Radiation therapy ,Brain-Tumor Recurrence ,ROC Curve ,True Progression ,Neoplasm Recurrence, Local ,business ,Nuclear medicine ,Glioblastoma ,Biomarkers - Abstract
International audience; To identify relevant relative cerebral blood volume biomarkers from T2* dynamic-susceptibility contrast magnetic resonance imaging to anticipate glioblastoma progression after chemoradiation. Twenty-five patients from a prospective study with glioblastoma, primarily treated by chemoradiation, were included. According to the last follow-up MRI confirmed status, patients were divided into: relapse group (n = 13) and control group (n = 12). The time of last MR acquisition was t(end); MR acquisitions performed at t(end-2M), t(end-4M) and t(end-6M) (respectively 2, 4 and 6 months before t(end)) were analyzed to extract relevant variations among eleven perfusion biomarkers (B). These variations were assessed through R(B), as the absolute value of the ratio between a dagger B from t(end-4M) to t(end-2M) and a dagger B from t(end-6M) to t(end-4M). The optimal cut-off for R(B) was determined using receiver-operating-characteristic curve analysis. The fraction of hypoperfused tumor volume (F_hP(g)) was a relevant biomarker. A ratio R(F_hP(g)) aeyenaEuroe0.61 would have been able to anticipate relapse at the next follow-up with a sensitivity/specificity/accuracy of 92.3 %/63.6 %/79.2 %. High R(F_hPg) (aeyen0.61) was associated with more relapse at t(end) compared to low R(F_hPg) (75 % vs 12.5 %, p = 0.008). Iterative analysis of F_hP(g) from consecutive examinations could provide surrogate markers to predict progression at the next follow-up. aEuro cent Related rCBV biomarkers from DSC were assessed to anticipate GBM progression. aEuro cent Biomarkers were assessed through their patterns of variation during the follow-up. aEuro cent The fraction of hypoperfused tumour volume (F_hP (g) ) seemed to be a relevant biomarker. aEuro cent An innovative ratio R(F_hP (g) ) could be an early surrogate marker of relapse. aEuro cent A significant time gain could be achieved in the management of GBM patients.
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- 2015
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43. PO-0647: Subventricular zones: new key targets for glioblastoma treatment
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Jean-Albert Lotterie, Vincent Lubrano, F. Tensaouti, B. Plas, J. Khalifa, E. Cohen-Jonathan Moyal, Amélie Lusque, and Emmanuelle Uro-Coste
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Oncology ,Radiology Nuclear Medicine and imaging ,medicine ,Cancer research ,Key (cryptography) ,Radiology, Nuclear Medicine and imaging ,Hematology ,Biology ,medicine.disease ,Glioblastoma - Published
- 2016
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44. [Management of locally advanced anal canal carcinoma with modulated arctherapy and concurrent chemotherapy]
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I, Troussier, F, Huguet, S, Servagi-Vernat, C, Benahim, J, Khalifa, I, Darmon, C, Ortholan, L, Krebs, C, Dejean, P, Fenoglietto, S, Vieillot, R-J, Bensadoun, and J, Thariat
- Subjects
Organs at Risk ,Quality Control ,Lymphatic Irradiation ,Phantoms, Imaging ,Mitomycin ,Radiotherapy Planning, Computer-Assisted ,Anal Canal ,Radiotherapy Dosage ,Chemoradiotherapy ,Anus Neoplasms ,Clinical Trials, Phase III as Topic ,Antineoplastic Combined Chemotherapy Protocols ,Preoperative Care ,Carcinoma, Squamous Cell ,Humans ,Computer Simulation ,Neoplasm Invasiveness ,Fluorouracil ,Radiotherapy, Intensity-Modulated ,Neoplasm Recurrence, Local ,Radiodermatitis ,Radiation Injuries ,Neoplasm Staging - Abstract
The standard treatment of locally advanced (stage II and III) squamous cell carcinoma of the anal canal consists of concurrent chemoradiotherapy (two cycles of 5-fluoro-uracil, mitomycin C, on a 28-day cycle), with a dose of 45 Gy in 1.8 Gy per fraction in the prophylactic planning target volume and additional 14 to 20 Gy in the boost planning target volume (5 days per week) with a possibility of 15 days gap period between the two sequences. While conformal irradiation may only yield suboptimal tumor coverage using complex photon/electron field junctions (especially on nodal areas), intensity modulated radiation therapy techniques (segmented static, dynamic, volumetric modulated arc therapy and helical tomotherapy) allow better tumour coverage while sparing organs at risk from intermediate/high doses (small intestine, perineum/genitalia, bladder, pelvic bone, etc.). Such dosimetric advantages result in fewer severe acute toxicities and better potential to avoid a prolonged treatment break that increases risk of local failure. These techniques also allow a reduction in late gastrointestinal and skin toxicities of grade 3 or above, as well as better functional conservation of anorectal sphincter. The technical achievements (simulation, contouring, prescription dose, treatment planning, control quality) of volumetric modulated arctherapy are discussed.
- Published
- 2014
45. Cancers anaplasiques de la thyroïde : étude du Rare Cancer Network
- Author
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X.S. Sun, C. Carrie, H. Qiu, Juliette Thariat, Ulrike Schick, Jean-Christophe Faivre, Gil Bar-Sela, T.T. Sio, J. Khalifa, and Candan Demiroz
- Subjects
Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectifs Les cancers anaplasiques de la thyroide sont des maladies rares et de pronostic tres defavorable, avec une duree mediane de survie de 10 mois. L’objectif de cette etude etait d’evaluer l’impact sur la survie globale de la strategie therapeutique multimodale. Patients et methodes Les dossiers des patients atteints de cancer anaplasique de la thyroide traite a une dose d’au moins 40 Gy dans les centres du groupe du Rare Cancer Network ont ete analyses. Resultats Au total, parmi les 140 cancers anaplasiques de la thyroide, 25 % avaient une double composante differenciee et indifferenciee. Treize patients ont recu une chimiotherapie neoadjuvante (avec differents protocoles), avec 63 % de reponses partielles. Parmi 68 patients ayant ete operes (dont 63 % par thyroidectomie totale, 70 % avec curage ganglionnaire cervical), 18 % ont eu une exerese complete. Quatre-vingt pour cent des patients ont recu une chimioradiotherapie concomitante (y compris par doxorubicine, docetaxel, cisplatine, carboplatine), 80 % des patients ont eu une radiotherapie externe dans de larges volumes, 20 % dans des volumes limites, et une dose mediane de 60 Gy a ete delivree. Les durees medianes de controle locoregional, survie sans metastase et survie globale etaient respectivement de 16, 14 et 17 mois. L’analyse multifactorielle a montre que la chirurgie et une haute dose de radiotherapie etaient des facteurs independants de la survie globale. Les patients ayant recu une radiotherapie conformationnelle avec modulation d’intensite semblent avoir de meilleurs resultats. Conclusion L’etude est en cours, il faut probablement jusqu’a 300 patients pour confirmer l’ordre optimal entre la chirurgie, la chimiotherapie et la radiotherapie.
- Published
- 2015
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46. [Choice of optimal margins in prostate conformal radiotherapy]
- Author
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J, Khalifa, F, Commandeur, J-M, Bachaud, and R, de Crevoisier
- Subjects
Male ,Prostatectomy ,Radiotherapy Planning, Computer-Assisted ,Humans ,Prostatic Neoplasms ,Lymph Nodes ,Radiotherapy, Conformal ,Magnetic Resonance Imaging - Abstract
The planning CT allows the delineation of the prostate (clinical target volume, CTV) but with an imprecision at the apex and the inability to visualize the intraprostatic cancer. MRI enables accurate visualization of the prostate outlines and in some extent the intraprostatic tumour (gross tumour volume [GTV]). The integration of MRI data within the CT remains still complex. Analysis of prostatectomy specimen has guided the definition of a CTV beyond the capsule, depending on pretreatment factors. In practice, the CTV can be defined as follows: prostate-only, for good prognosis tumours; prostate (+0 to 5mm margins, excluding the rectum) and seminal vesicles (possibly limited to 2 cm of their proximal region) for intermediate-risk tumours; prostate (+5mm margins) and seminal vesicles for high-risk tumours. The planning target volume (PTV) should be between 5mm and 10mm depending on the space directions, in the absence of image-guidance (IGRT). It could be reduced to 5mm in case of IGRT. In the adjuvant setting after prostatectomy, the definition of the CTV should follow the recommendations from cooperative groups. It takes into account both the analysis of pattern of local recurrence after prostatectomy, but also the specific histological analysis of the surgical specimen of the patient. The corresponding PTV margin is 6 to 8mm.
- Published
- 2013
47. Zones subventriculaires : de nouvelles cibles pour le traitement des glioblastomes
- Author
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Jean-Albert Lotterie, Amélie Lusque, Emmanuelle Uro-Coste, Alexandra Benouaich-Amiel, F. Tensaouti, E. Cohen-Jonathan Moyal, J. Khalifa, Vincent Lubrano, and B. Plas
- Subjects
Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
Objectif de l’etude Les zones subventriculaires sont considerees comme une source potentielle de cellules souches de glioblastome. L’objet de l’etude etait d’identifier des facteurs pronostiques de survie en lien avec ces zones subventriculaires parmi des patients atteints de glioblastome. Materiels et methodes Quarante-trois patients traites de premiere intention pour un glioblastome dans notre centre entre 2006 et 2010 ont ete identifies. Tous les patients ont recu apres une resection chirurgicale une chimioradiotherapie (protocole de Stupp et al.). Les zones subventriculaires homolaterales, controlaterales et bilaterales ont ete delineees retrospectivement et les histogrammes dose-volume analyses. Une analyse multifactorielle utilisant le modele de Cox a evalue l’impact des differents facteurs pronostiques lies aux zones subventriculaires sur le temps jusqu’a progression et la survie globale. Cette etude a ete approuvee par notre comite d’ethique local. Resultats Le suivi median, la survie globale mediane et le temps jusqu’a progression mediane etaient respectivement de 22,7 mois (7,5–69,7 mois), 22,7 mois (intervalle de confiance a 95 % [IC 95 %] : 14,5–26,2 mois) et 6,4 mois (IC 95 % : 4,4–9,3 mois). En analyse univafactorielle, le contact initial a la zone subventriculaire etait un facteur pronostique defavorable de survie globale (18,7 contre 41,7 mois, p = 0,014) et de temps jusqu’a progression (4,6 contre 12,9 mois, p = 0,002). Les patients dont le volume de zones subventriculaires recevant plus de 20 Gy etait superieur a 84 % avaient un temps jusqu’a progression significativement plus long (17,7 contre 5,2 mois, p = 0,017). Cette couverture de dose etait compatible avec une epargne hippocampique. En analyse multifactorielle, le contact initial a la zone subventriculaire et un volume de zones subventriculaires recevant plus de 20 Gy de moins de 84 % restaient des facteurs pronostiques defavorable de temps jusqu’a progression (respectivement, HR = 3,07, p = 0,012 et HR = 2,67, p = 0,047). Conclusion Nos resultats suggerent qu’un contact tumoral a la SVZ zone subventriculaire, de meme qu’une couverture de dose insuffisante de la zone subventriculaire recevant plus de 20 Gy (moins de 84 %) sont des facteurs defavorables independants de temps jusqu’a progression. Le ciblage de la zone subventriculaire en radiotherapie pourrait donc etre d’un interet crucial pour l’optimisation du traitement des glioblastomes.
- Published
- 2016
- Full Text
- View/download PDF
48. PO-158: The Role of concomitant radiochemotherapy in Anaplastic Thyroid Carcinomas (ATC): A study of the Rare Cancer Network
- Author
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Jianji Pan, Gil Bar-Sela, Juliette Thariat, P. Boisselier, Terence T. Sio, Jean-Christophe Faivre, X. Sun, J. Khalifa, Robert C. Miller, and Candan Demiroz
- Subjects
Thyroid carcinoma ,Oncology ,medicine.medical_specialty ,business.industry ,Concomitant ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Hematology ,business ,Rare cancer - Published
- 2015
- Full Text
- View/download PDF
49. Prognosis of Irradiated Anaplastic Thyroid Carcinomas: A Rare Cancer Network Study
- Author
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C. Carrie, H. Qiu, Xu Shan Sun, J. Faivre, T.T. Sio, Gil Bar-Sela, Juliette Thariat, and J. Khalifa
- Subjects
Thyroid carcinoma ,Oncology ,Cancer Research ,medicine.medical_specialty ,Radiation ,business.industry ,Internal medicine ,medicine ,Cancer research ,Radiology, Nuclear Medicine and imaging ,business ,Rare cancer - Published
- 2014
- Full Text
- View/download PDF
50. Zinc toxicity from massive and prolonged coin ingestion in an adult
- Author
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Firdous Siddiqui, Charles A Schiffer, Murray N. Ehrinpreis, Swati Pawa, and Ahmad J Khalifa
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Male ,medicine.medical_specialty ,Anemia ,chemistry.chemical_element ,Zinc ,medicine.disease_cause ,Gastroenterology ,Numismatics ,Internal medicine ,medicine ,Ingestion ,Humans ,Pica (disorder) ,Gastrointestinal tract ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Foreign Bodies ,Surgery ,Gastrointestinal Tract ,chemistry ,Zinc toxicity ,Toxicity ,Pica ,Schizophrenia ,medicine.symptom ,business ,Copper deficiency ,Copper - Abstract
Acquired copper deficiency anemia is rare in humans. This report describes a 38-year-old schizophrenic man with metal pica, especially coins, who presented with symptomatic anemia. Two hundred seventy-five coins were surgically removed from the gastrointestinal tract of this patient during the course of his hospitalization. Some of the post-1981 pennies, which consist primarily of zinc, showed severe corrosion because of their prolonged contact with acidic gastric juice. The patient presented with clinical manifestations consistent with the local corrosive as well as the systemic effects of zinc intoxication. His treatment and outcome are presented. The effects of zinc intoxication on hematologic and other organ systems and on copper absorption are discussed.
- Published
- 2008
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