Search

Your search keyword '"James R. Seay"' showing total 3 results
Start Over Author "James R. Seay"
3 results on '"James R. Seay"'

2. The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.

Author

Seteena L Ueberschlag, James R Seay, Alexandra H Roberts, Pamela C DeSpirito, Jeremy M Stith, Rodney J Folz, Kathleen A Carter, Edward P Weiss, and Gerald S Zavorsky

Subjects
Medicine, Science
Abstract

The purpose of this study determined if oral supplementation of Protandim® (a nutraceutical) for 90 days improved 5-km running performance and reduced serum thiobarbituric acid-reacting substances (TBARS) at rest, an indicator of oxidative stress. Secondary objectives were to measure whole blood superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), at rest and 10 minutes after completion of the race before and after supplementation as well as quality of life. In a double-blind, randomized, placebo controlled trial, 38 runners [mean (SD) = 34 (7) yrs; BMI = 22 (2) kg/m2] received either 90 days of Protandim® [1 pill a day, n = 19)] or placebo (n = 19). Randomization was done in blocks of two controlling for sex and 5-km baseline performance. A 5-km race was performed at baseline and after 90 days of supplementation, with blood samples taken before and 10-min after each race. Fasting blood samples were acquired at baseline, after 30, 60, and 90 days of supplementation. TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim® or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) after three months of Protandim® supplementation compared to placebo. However, in a subgroup ≥ 35 years of age, there was a 2-fold higher increase in SOD in those taking Protandim® for three months compared to those on placebo (p = 0.038). The mean post-race change in TBARS (compared to pre-race) increased by about 20% in half of the subjects, but was not altered between groups, even after three months of supplementation. Quality of life was also not different between the two conditions. In conclusion, Protandim® did not (1) alter 5-km running time, (2) lower TBARS at rest (3) raise antioxidant enzyme concentrations compared to placebo (with exception of SOD in those ≥ 35 years old) or, (4) affect quality of life compared to placebo.ClinicalTrials.gov NCT02172625.

Published
2016
Full Text
View/download PDF

3. The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners

Author

James R. Seay, Pamela C. DeSpirito, Kathleen A. Carter, Edward P. Weiss, Alexandra H. Roberts, Rodney J. Folz, Gerald S. Zavorsky, Seteena L. Ueberschlag, Jeremy M. Stith, and Dal Pizzol, Felipe

Subjects
0301 basic medicine, Male, Physiology, Chinese Herbal, Placebo-controlled study, lcsh:Medicine, Biochemistry, Antioxidants, law.invention, Running, Lipid peroxidation, chemistry.chemical_compound, Oxidative Damage, 0302 clinical medicine, Randomized controlled trial, law, Medicine and Health Sciences, Medicine, Amino Acids, lcsh:Science, Whole blood, chemistry.chemical_classification, Multidisciplinary, Organic Compounds, Glutathione peroxidase, Drugs, Hematology, Middle Aged, Lipids, Glutathione, Body Fluids, Enzymes, Chemistry, Blood, Dismutases, 6.1 Pharmaceuticals, Physical Sciences, Female, Anatomy, Oxidation-Reduction, Research Article, Adult, medicine.medical_specialty, Randomization, General Science & Technology, Science, Clinical Trials and Supportive Activities, Athletic Performance, Placebo, Thiobarbituric Acid Reactive Substances, 03 medical and health sciences, Double-Blind Method, Clinical Research, Internal medicine, Complementary and Integrative Health, TBARS, Humans, Sulfur Containing Amino Acids, Cysteine, Nutrition, Glutathione Peroxidase, business.industry, Superoxide Dismutase, Prevention, lcsh:R, Organic Chemistry, Chemical Compounds, Evaluation of treatments and therapeutic interventions, Correction, Biology and Life Sciences, Proteins, 030229 sport sciences, Cell Biology, Surgery, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, Dietary Supplements, Quality of Life, Enzymology, lcsh:Q, Lipid Peroxidation, business, Peptides, Drugs, Chinese Herbal
Abstract

The purpose of this study determined if oral supplementation of Protandim® (a nutraceutical) for 90 days improved 5-km running performance and reduced serum thiobarbituric acid-reacting substances (TBARS) at rest, an indicator of oxidative stress. Secondary objectives were to measure whole blood superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GPX), at rest and 10 minutes after completion of the race before and after supplementation as well as quality of life. In a double-blind, randomized, placebo controlled trial, 38 runners [mean (SD) = 34 (7) yrs; BMI = 22 (2) kg/m2] received either 90 days of Protandim® [1 pill a day, n = 19)] or placebo (n = 19). Randomization was done in blocks of two controlling for sex and 5-km baseline performance. A 5-km race was performed at baseline and after 90 days of supplementation, with blood samples taken before and 10-min after each race. Fasting blood samples were acquired at baseline, after 30, 60, and 90 days of supplementation. TBARS, SOD, GPX, and GSH were assayed in an out-of-state accredited lab. Running performance was not altered by Protandim® or placebo [20.3 (2.1) minutes, with an -8 (33) seconds change in 5-km time regardless of group]. There was no change in TBARS, SOD, or GPX (at rest) after three months of Protandim® supplementation compared to placebo. However, in a subgroup ≥ 35 years of age, there was a 2-fold higher increase in SOD in those taking Protandim® for three months compared to those on placebo (p = 0.038). The mean post-race change in TBARS (compared to pre-race) increased by about 20% in half of the subjects, but was not altered between groups, even after three months of supplementation. Quality of life was also not different between the two conditions. In conclusion, Protandim® did not (1) alter 5-km running time, (2) lower TBARS at rest (3) raise antioxidant enzyme concentrations compared to placebo (with exception of SOD in those ≥ 35 years old) or, (4) affect quality of life compared to placebo. Trial Registration: ClinicalTrials.gov {"type":"clinical-trial","attrs":{"text":"NCT02172625","term_id":"NCT02172625"}}NCT02172625

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results