240 results on '"Janssen, Nicole A. H."'
Search Results
2. Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study
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Loef, Bette, Herber, Gerrie-Cor M., Wong, Albert, Janssen, Nicole A. H., Hoekstra, Jurriaan, Picavet, H. Susan J., and Verschuren, W. M. Monique
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- 2023
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3. Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland
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Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard
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- 2023
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4. Using random forest to identify longitudinal predictors of health in a 30-year cohort study
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Loef, Bette, Wong, Albert, Janssen, Nicole A. H., Strak, Maciek, Hoekstra, Jurriaan, Picavet, H. Susan J., Boshuizen, H. C. Hendriek, Verschuren, W. M. Monique, and Herber, Gerrie-Cor M.
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- 2022
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5. Long-term exposure to low ambient air pollution concentrations and mortality among 28 million people: results from seven large European cohorts within the ELAPSE project
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Stafoggia, Massimo, Oftedal, Bente, Chen, Jie, Rodopoulou, Sophia, Renzi, Matteo, Atkinson, Richard W, Bauwelinck, Mariska, Klompmaker, Jochem O, Mehta, Amar, Vienneau, Danielle, Andersen, Zorana J, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, de Hoogh, Kees, Fecht, Daniela, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla A, Jöckel, Karl-Heinz, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Kristoffersen, Doris Tove, Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter L S, Nagel, Gabriele, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Rizzuto, Debora, Schramm, Sara, Schwarze, Per E, Severi, Gianluca, Sigsgaard, Torben, Strak, Maciek, van der Schouw, Yvonne T, Verschuren, Monique, Weinmayr, Gudrun, Wolf, Kathrin, Zitt, Emanuel, Samoli, Evangelia, Forastiere, Francesco, Brunekreef, Bert, Hoek, Gerard, and Janssen, Nicole A H
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- 2022
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6. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project
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Wolf, Kathrin, Hoffmann, Barbara, Andersen, Zorana J, Atkinson, Richard W, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Brunekreef, Bert, Cesaroni, Giulia, Chen, Jie, de Faire, Ulf, de Hoogh, Kees, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hvidtfeldt, Ulla Arthur, Janssen, Nicole A H, Jørgensen, Jeanette T, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O, Lager, Anton, Liu, Shuo, MacDonald, Conor J, Magnusson, Patrik K E, Mehta, Amar J, Nagel, Gabriele, Oftedal, Bente, Pedersen, Nancy L, Pershagen, Göran, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Rodopoulou, Sophia, Samoli, Evangelia, van der Schouw, Yvonne T, Schramm, Sara, Schwarze, Per, Sigsgaard, Torben, Sørensen, Mette, Stafoggia, Massimo, Strak, Maciek, Tjønneland, Anne, Verschuren, W M Monique, Vienneau, Danielle, Weinmayr, Gudrun, Hoek, Gerard, Peters, Annette, and Ljungman, Petter L S
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- 2021
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7. Effects of exposure to surrounding green, air pollution and traffic noise with non-accidental and cause-specific mortality in the Dutch national cohort
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Klompmaker, Jochem O., Janssen, Nicole A. H., Bloemsma, Lizan D., Marra, Marten, Lebret, Erik, Gehring, Ulrike, and Hoek, Gerard
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- 2021
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8. Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter
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Burnett, Richard, Chen, Hong, Szyszkowicz, Mieczysław, Fann, Neal, Hubbell, Bryan, Pope, C. Arden, Apte, Joshua S., Brauer, Michael, Cohen, Aaron, Weichenthal, Scott, Coggins, Jay, Di, Qian, Brunekreef, Bert, Frostad, Joseph, Lim, Stephen S., Kan, Haidong, Walker, Katherine D., Thurston, George D., Hayes, Richard B., Lim, Chris C., Turner, Michelle C., Jerrett, Michael, Krewski, Daniel, Gapstur, Susan M., Diver, W. Ryan, Ostro, Bart, Goldberg, Debbie, Crouse, Daniel L., Martin, Randall V., Peters, Paul, Pinault, Lauren, Tjepkema, Michael, van Donkelaar, Aaron, Villeneuve, Paul J., Miller, Anthony B., Yin, Peng, Zhou, Maigeng, Wang, Lijun, Janssen, Nicole A. H., Marra, Marten, Atkinson, Richard W., Tsang, Hilda, Thach, Thuan Quoc, Cannon, John B., Allen, Ryan T., Hart, Jaime E., Laden, Francine, Cesaroni, Giulia, Forastiere, Francesco, Weinmayr, Gudrun, Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, and Spadaro, Joseph V.
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- 2018
9. Long-Term Exposure to Low-Level PM2.5 and Mortality: Investigation of Heterogeneity by Harmonizing Analyses in Large Cohort Studies in Canada, United States, and Europe.
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Jie Chen, Braun, Danielle, Christidis, Tanya, Cork, Michael, Rodopoulou, Sophia, Samoli, Evangelia, Stafoggia, Massimo, Wolf, Kathrin, Xiao Wu, Weiran Yuchi, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, de Hoogh, Kees, Janssen, Nicole A. H., Katsouyanni, Klea, Klompmaker, Jochem O., Kristoffersen, Doris Tove, Youn-Hee Lim, and Oftedal, Bente
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MORTALITY risk factors ,PARTICULATE matter ,AERODYNAMICS ,RELATIVE medical risk ,CONFIDENCE intervals ,NOSOLOGY ,META-analysis ,RISK assessment ,SOCIAL classes ,DESCRIPTIVE statistics ,DATA analysis software ,ENVIRONMENTAL exposure ,LONGITUDINAL method ,PROPORTIONAL hazards models ,MEDICARE ,POISSON distribution - Abstract
BACKGROUND: Studies across the globe generally reported increased mortality risks associated with particulate matter with aerodynamic diameter ≤2.5 μm (PM
2.5 ) exposure with large heterogeneity in the magnitude of reported associations and the shape of concentration-response functions (CRFs). We aimed to evaluate the impact of key study design factors (including confounders, applied exposure model, population age, and outcome definition) on PM2.5 effect estimates by harmonizing analyses on three previously published large studies in Canada [Mortality-Air Pollution Associations in Low Exposure Environments (MAPLE), 1991-2016], the United States (Medicare, 2000-2016), and Europe [Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), 2000-2016] as much as possible. METHODS: We harmonized the study populations to individuals 65+ years of age, applied the same satellite-derived PM2.5 exposure estimates, and selected the same sets of potential confounders and the same outcome. We evaluated whether differences in previously published effect estimates across cohorts were reduced after harmonization among these factors. Additional analyses were conducted to assess the influence of key design features on estimated risks, including adjusted covariates and exposure assessment method. A combined CRF was assessed with meta-analysis based on the extended shape-constrained health impact function (eSCHIF). RESULTS: More than 81 million participants were included, contributing 692 million person-years of follow-up. Hazard ratios and 95% confidence intervals (CIs) for all-cause mortality associated with a 5-μg/m³ increase in PM2.5 were 1.039 (1.032, 1.046) in MAPLE, 1.025 (1.021, 1.029) in Medicare, and 1.041 (1.014, 1.069) in ELAPSE. Applying a harmonized analytical approach marginally reduced difference in the observed associations across the three studies. Magnitude of the association was affected by the adjusted covariates, exposure assessment methodology, age of the population, and marginally by outcome definition. Shape of the CRFs differed across cohorts but generally showed associations down to the lowest observed PM2.5 levels. A common CRF suggested a monotonically increased risk down to the lowest exposure level. [ABSTRACT FROM AUTHOR]- Published
- 2023
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10. Joint Association of Long-term Exposure to Both O 3 and NO 2 with Children’s Respiratory Health
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Janssen, Nicole A. H., Hoek, Gerard, Fischer, Paul H., Wijga, Alet H., Koppelman, Gerard, de Jongste, Johan J., Brunekreef, Bert, and Gehring, Ulrike
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- 2017
11. Children's respiratory health and oxidative potential of PM₂.₅: the PIAMA birth cohort study
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Yang, Aileen, Janssen, Nicole A H, Brunekreef, Bert, Cassee, Flemming R, Hoek, Gerard, and Gehring, Ulrike
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- 2016
12. Additional file 1 of Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study
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Loef, Bette, Herber, Gerrie-Cor M., Wong, Albert, Janssen, Nicole A. H., Hoekstra, Jurriaan, Picavet, H. Susan J., and Verschuren, W. M. Monique
- Abstract
Additional file 1.
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- 2023
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13. Additional file 8 of Predicting self-perceived general health status using machine learning: an external exposome study
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Hoekstra, Jurriaan, Lenssen, Esther S., Wong, Albert, Loef, Bette, Herber, Gerrie-Cor M., Boshuizen, Hendriek C., Strak, Maciek, Verschuren, W. M. Monique, and Janssen, Nicole A. H.
- Abstract
Additional file 8: Figure S1. Partial dependance plots of a selection of top ranked categorical variables within a random forest model to predict self-perceived general health status. Figure S2. Accumulated local effects plots of a selection of top continuous variables within a random forest model to predict self-perceived general health status.
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- 2023
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14. Additional file 1 of Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland
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Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard
- Abstract
Additional file 1: Table S1. Study population selection. Table S2. Exposure distributions. Table S3. Spearman correlations between exposures (top), and between exposures and neighbourhood socio-economic position (SEP) score (bottom). Table S4. Mean exposure by quintiles of neighbourhood socio-economic position. Table S5. Hazard ratios (95% confidence intervals) for single exposure associations between air pollution and noise exposures and mortality by cause, with increasing level of covariate adjustment in single exposure models. Table S6. Effect modification by sex, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3). Table S7. Non-mover analysis, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3).
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- 2023
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15. Associations between three specific a-cellular measures of the oxidative potential of participate matter and markers of acute airway and nasal inflammation in healthy volunteers
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Janssen, Nicole A H, Strak, Maciej, Yang, Aileen, Hellack, Bryan, Kelly, Frank J, Kuhlbusch, Thomas A J, Harrison, Roy M, Brunekreef, Bert, Cassee, Flemming R, Steenhof, Maaike, and Hoek, Gerard
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- 2015
16. Respiratory Effects of a Reduction in Outdoor Air Pollution Concentrations
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Boogaard, Hanna, Fischer, Paul H., Janssen, Nicole A. H., Kos, Gerard P.A., Weijers, Ernie P., Cassee, Flemming R., van der Zee, Saskia C., de Hartog, Jeroen J., Meliefste, Kees, Wang, Meng, Brunekreef, Bert, and Hoek, Gerard
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- 2013
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17. Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project
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Strak, Maciej, Hoek, Gerard, Steenhof, Maaike, Kilinc, Evren, Godri, Krystal J, Gosens, Ilse, Mudway, Ian S, van Oerle, René, Spronk, Henri M H, Cassee, Flemming R, Kelly, Frank J, Harrison, Roy M, Brunekreef, Bert, Lebret, Erik, and Janssen, Nicole A H
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- 2013
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18. Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project
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Steenhof, Maaike, Mudway, Ian S, Gosens, Ilse, Hoek, Gerard, Godri, Krystal J, Kelly, Frank J, Harrison, Roy M, Pieters, Raymond H H, Cassee, Flemming R, Lebret, Erik, Brunekreef, Bert A, Strak, Maciej, and Janssen, Nicole A H
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- 2013
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19. Joint Association of Long-term Exposure to Both O3 and NO2 with Children’s Respiratory Health
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Janssen, Nicole A. H., Hoek, Gerard, Fischer, Paul H., Wijga, Alet H., Koppelman, Gerard, de Jongste, Johan J., Brunekreef, Bert, and Gehring, Ulrike
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- 2017
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20. Contrasts in Oxidative Potential and Other Particulate Matter Characteristics Collected Near Major Streets and Background Locations
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Boogaard, Hanna, Janssen, Nicole A. H., Fischer, Paul H., Kos, Gerard P.A., Weijers, Ernie P., Cassee, Flemming R., van der Zee, Saskia C., de Hartog, Jeroen J., Brunekreef, Bert, and Hoek, Gerard
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- 2012
21. Effects of Ambient Air Pollution on Hemostasis and Inflammation
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Rudež, Goran, Janssen, Nicole A. H., Kilinc, Evren, Leebeek, Frank W. G., Gerlofs-Nijland, Miriam E., Spronk, Henri M. H., Cate, Hugo ten, Cassee, Flemming R., and de Maat, Moniek P. M.
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- 2009
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22. Associations between ${\rm{PM}}_{2.5}$ and Heart Rate Variability Are Modified by Particle Composition and Beta-Blocker Use in Patients with Coronary Heart Disease
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de Hartog, Jeroen J., Lanki, Timo, Timonen, Kirsi L., Hoek, Gerard, Janssen, Nicole A. H., Ibald-Mulli, Angela, Peters, Annette, Heinrich, Joachim, Tarkiainen, Tuula H., van Grieken, Rene, van Wijnen, Joop H., Brunekreef, Bert, and Pekkanen, Juha
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- 2009
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23. Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis
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Strak, Maciej, primary, Weinmayr, Gudrun, additional, Rodopoulou, Sophia, additional, Chen, Jie, additional, de Hoogh, Kees, additional, Andersen, Zorana J, additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bekkevold, Terese, additional, Bellander, Tom, additional, Boutron-Ruault, Marie-Christine, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla Arthur, additional, Janssen, Nicole A H, additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette T, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O, additional, Lager, Anton, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter, additional, Magnusson, Patrik K E, additional, Mehta, Amar J, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, van der Schouw, Yvonne T, additional, Schramm, Sara, additional, Severi, Gianluca, additional, Sigsgaard, Torben, additional, Sørensen, Mette, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Verschuren, W M Monique, additional, Vienneau, Danielle, additional, Wolf, Kathrin, additional, Katsouyanni, Klea, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Samoli, Evangelia, additional
- Published
- 2021
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24. Green space, air pollution, traffic noise and mental wellbeing throughout adolescence: Findings from the PIAMA study
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Bloemsma, Lizan D, Wijga, Alet H, Klompmaker, Jochem O, Hoek, Gerard, Janssen, Nicole A H, Lebret, Erik, Brunekreef, Bert, Gehring, Ulrike, IRAS OH Epidemiology Chemical Agents, IRAS OH Epidemiology Microbial Agents, IRAS OH Epidemiology Chemical Agents, and IRAS OH Epidemiology Microbial Agents
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MHI-5 ,Adult ,Air Pollutants ,Traffic-Related Pollution ,Adolescent ,NDVI ,Parks, Recreational ,Environmental exposures ,Environmental Exposure ,Adolescents ,Young Adult ,Environmental Science(all) ,Air Pollution ,Humans ,Particulate Matter ,Child ,General Environmental Science - Abstract
BACKGROUND: Green space, air pollution and traffic noise exposure may be associated with mental health in adolescents. We assessed the associations of long-term exposure to residential green space, ambient air pollution and traffic noise with mental wellbeing from age 11 to 20 years. METHODS: We included 3059 participants of the Dutch PIAMA birth cohort who completed the five-item Mental Health Inventory (MHI-5) at ages 11, 14, 17 and/or 20 years. We estimated exposure to green space (the average Normalized Difference Vegetation Index (NDVI) and percentages of green space in circular buffers of 300 m, 1000 m and 3000 m), ambient air pollution (particulate matter (PM10 and PM2.5), nitrogen dioxide, PM2.5 absorbance and the oxidative potential of PM2.5) and road traffic and railway noise (Lden) at the adolescents' home addresses at the times of completing the MHI-5. Associations with poor mental wellbeing (MHI-5 score ≤ 60) were assessed by generalized linear mixed models with a logit link, adjusting for covariates. RESULTS: The odds of poor mental wellbeing at age 11 to 20 years decreased with increasing exposure to green space in a 3000 m buffer (adjusted odds ratio (OR) 0.78 [95% CI 0.68-0.88] per IQR increase in the average NDVI; adjusted OR 0.77 [95% CI 0.67-0.88] per IQR increase in the total percentage of green space). These associations persisted after adjustment for air pollution and road traffic noise. Relationships between mental wellbeing and green space in buffers of 300 m and 1000 m were less consistent. Higher air pollution exposure was associated with higher odds of poor mental wellbeing, but these associations were strongly attenuated after adjustment for green space in a buffer of 3000 m, traffic noise and degree of urbanization. Traffic noise was not related to mental wellbeing throughout adolescence. CONCLUSIONS: Residential exposure to green space may be associated with a better mental wellbeing in adolescents.
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- 2021
25. Green space, air pollution, traffic noise and saliva cortisol in children: The PIAMA study
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Bloemsma, Lizan D, Wijga, Alet H, Klompmaker, Jochem O, Hoek, Gerard, Janssen, Nicole A H, Oldenwening, Marieke, Koppelman, Gerard H, Lebret, Erik, Brunekreef, Bert, Gehring, Ulrike, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, Dep IRAS, IRAS OH Epidemiology Microbial Agents, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, Dep IRAS, IRAS OH Epidemiology Microbial Agents, and Groningen Research Institute for Asthma and COPD (GRIAC)
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endocrine system ,Global and Planetary Change ,Evening ,Cortisol awakening response ,Epidemiology ,business.industry ,Health, Toxicology and Mutagenesis ,Stressor ,Traffic noise ,Public Health, Environmental and Occupational Health ,Air pollution ,medicine.disease_cause ,Pollution ,Environmental health ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Medicine ,Chronic stress ,Circadian rhythm ,Original Research Article ,business ,Morning - Abstract
Supplemental Digital Content is available in the text., Background: Green space, air pollution, and traffic noise exposure may be associated with stress levels in children. A flattened diurnal cortisol slope (the decline in cortisol concentrations from awakening to evening) is an indicator of chronic stress. We examined associations of green space, ambient air pollution, and traffic noise with the diurnal cortisol slope in children 12 years of age. Methods: At age 12 years, 1,027 participants of the Dutch PIAMA birth cohort collected three saliva samples during 1 day. We estimated residential exposure to green space (i.e., the average Normalized Difference Vegetation Index [NDVI] and percentages of green space in circular buffers of 300 m and 3,000 m), air pollution, and traffic noise. Associations of these exposures with the diurnal cortisol slope (in nmol/L per hour) were assessed by multiple linear regression, adjusting for potential confounders. Results: Higher average NDVI and total percentage of green space in a 3,000 m buffer were associated with a larger diurnal decrease in cortisol levels (adjusted difference [95% confidence interval] = −0.11 nmol/L/hr [−0.21, 0.00 nmol/L/hr] per interquartile range increase in the average NDVI; −0.13 nmol/L/hr [−0.26, 0.00 nmol/L/hr] per interquartile range increase in the total percentage of green space). These associations were largely driven by associations with the percentage of agricultural green space and by associations in children living in nonurban areas. We observed no relationships between air pollution or traffic noise and the diurnal cortisol slope. Conclusions: Residential exposure to green space in a buffer of 3,000 m may be associated with lower stress levels in children 12 years of age.
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- 2021
26. Mass Concentration and Elemental Composition of PM10 in Classrooms
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Janssen, Nicole A. H., Hoek, Gerard, Brunekreef, Bert, and Harssema, Hendrik
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- 1999
27. Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis
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Strak, Maciej Weinmayr, Gudrun Rodopoulou, Sophia Chen, Jie and de Hoogh, Kees Andersen, Zorana J. Atkinson, Richard and Bauwelinck, Mariska Bekkevold, Terese Bellander, Tom and Boutron-Ruault, Marie-Christine Brandt, Jorgen Cesaroni, Giulia and Concin, Hans Fecht, Daniela Forastiere, Francesco and Gulliver, John Hertel, Ole Hoffmann, Barbara Hvidtfeldt, Ulla Arthur Janssen, Nicole A. H. Jockel, Karl-Heinz and Jorgensen, Jeanette Ketzel, Matthias Klompmaker, Jochem and Lager, Anton Leander, Karin Liu, Shuo Ljungman, Petter and Magnusson, Patrik K. E. Mehta, Amar J. Nagel, Gabriele and Oftedal, Bente Pershagen, Goran Peters, Annette and Raaschou-Nielsen, Ole Renzi, Matteo Rizzuto, Debora van der Schouw, Yvonne T. Schramm, Sara Severi, Gianluca Sigsgaard, Torben Sorensen, Mette Stafoggia, Massimo Tjonneland, Anne and Verschuren, W. M. Monique Vienneau, Danielle Wolf, Kathrin and Katsouyanni, Klea Brunekreef, Bert Hoek, Gerard Samoli, Evangelia
- Abstract
OBJECTIVE To investigate the associations between air pollution and mortality, focusing on associations below current European Union, United States, and World Health Organization standards and guidelines. DESIGN Pooled analysis of eight cohorts. SETTING Multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) in six European countries. PARTICIPANTS 325 367 adults from the general population recruited mostly in the 1990s or 2000s with detailed lifestyle data. Stratified Cox proportional hazard models were used to analyse the associations between air pollution and mortality. Western Europe-wide land use regression models were used to characterise residential air pollution concentrations of ambient fine particulate matter (PM2.5), nitrogen dioxide, ozone, and black carbon. MAIN OUTCOME MEASURES Deaths due to natural causes and cause specific mortality. RESULTS Of 325 367 adults followed-up for an average of 19.5 years, 47 131 deaths were observed. Higher exposure to PM2.5, nitrogen dioxide, and black carbon was associated with significantly increased risk of almost all outcomes. An increase of 5 mu g/m(3) in PM2.5 was associated with 13% (95% confidence interval 10.6% to 15.5%) increase in natural deaths; the corresponding figure for a 10 mu g/m(3) increase in nitrogen dioxide was 8.6% (7% to 10.2%). Associations with PM2.5, nitrogen dioxide, and black carbon remained significant at low concentrations. For participants with exposures below the US standard of 12 mu g/m(3) an increase of 5 mu g/m(3) in PM2.5 was associated with 29.6% (14% to 47.4%) increase in natural deaths. CONCLUSIONS Our study contributes to the evidence that outdoor air pollution is associated with mortality even at low pollution levels below the current European and North American standards and WHO guideline values. These findings are therefore an important contribution to the debate about revision of air quality limits, guidelines, and standards, and future assessments by the Global Burden of Disease.
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- 2021
28. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project
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Liu, Shuo Jorgensen, Jeanette Therming Ljungman, Petter and Pershagen, Goran Bellander, Tom Leander, Karin Magnusson, Patrik K. E. Rizzuto, Debora Hvidtfeldt, Ulla A. Nielsen, Ole Raaschou Wolf, Kathrin Hoffmann, Barbara Brnekree, Bert and Strak, Maciej Chen, Jie Mehta, Amar Atkinson, Richard W. and Bauwelrick, Mariska Varraso, Raphaelle Boutron-Ruault, Marie-Christine Brandt, Jorgen Cesaroni, Giulia Forastiere, Francesco Fecht, Daniela Gulliver, John Herte, Ole de Hoogh, Kees Janssen, Nicole A. H. Katsouyanni, Klea Ketzel, Matthias Klompmaker, Jochem O. Nagel, Gabriele Oftedal, Bente Peters, Annette Tjonneland, Anne Rodopoulou, Sophia P. and Samoli, Evangelia Kristoffersen, Doris Tove Sigsgaard, Torben Stafoggia, Massimo Vienneau, Danielle Weinmayr, Gudrun Hoek, Gerard Andersen, Zorana Jovanovic
- Abstract
Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter
- Published
- 2021
29. The Impact of Short-Term Exposure to Air Pollution on the Exhaled Breath of Healthy Adults
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Lammers, Ariana, primary, Neerincx, Anne H., additional, Vijverberg, Susanne J. H., additional, Longo, Cristina, additional, Janssen, Nicole A. H., additional, Boere, A. John F., additional, Brinkman, Paul, additional, Cassee, Flemming R., additional, and van der Zee, Anke H. Maitland, additional
- Published
- 2021
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30. Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project
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Chen, Jie, primary, Rodopoulou, Sophia, additional, de Hoogh, Kees, additional, Strak, Maciej, additional, Andersen, Zorana J., additional, Atkinson, Richard, additional, Bauwelinck, Mariska, additional, Bellander, Tom, additional, Brandt, Jørgen, additional, Cesaroni, Giulia, additional, Concin, Hans, additional, Fecht, Daniela, additional, Forastiere, Francesco, additional, Gulliver, John, additional, Hertel, Ole, additional, Hoffmann, Barbara, additional, Hvidtfeldt, Ulla Arthur, additional, Janssen, Nicole A. H., additional, Jöckel, Karl-Heinz, additional, Jørgensen, Jeanette, additional, Katsouyanni, Klea, additional, Ketzel, Matthias, additional, Klompmaker, Jochem O., additional, Lager, Anton, additional, Leander, Karin, additional, Liu, Shuo, additional, Ljungman, Petter, additional, MacDonald, Conor J., additional, Magnusson, Patrik K.E., additional, Mehta, Amar, additional, Nagel, Gabriele, additional, Oftedal, Bente, additional, Pershagen, Göran, additional, Peters, Annette, additional, Raaschou-Nielsen, Ole, additional, Renzi, Matteo, additional, Rizzuto, Debora, additional, Samoli, Evangelia, additional, van der Schouw, Yvonne T., additional, Schramm, Sara, additional, Schwarze, Per, additional, Sigsgaard, Torben, additional, Sørensen, Mette, additional, Stafoggia, Massimo, additional, Tjønneland, Anne, additional, Vienneau, Danielle, additional, Weinmayr, Gudrun, additional, Wolf, Kathrin, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional
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- 2021
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31. Childhood Exposure to PM10: Relation between Personal, Classroom, and Outdoor Concentrations
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Janssen, Nicole A. H., Hoek, Gerad, Harssema, Hendrik, and Brunekreef, Bert
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- 1997
32. Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air-liquid interface
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He, Rui-Wen, Gerlofs-Nijland, Miriam E, Boere, John, Fokkens, Paul, Leseman, Daan, Janssen, Nicole A H, Cassee, Flemming R, Dep IRAS, IRAS OH Toxicology, dIRAS RA-1, Dep IRAS, IRAS OH Toxicology, and dIRAS RA-1
- Subjects
0301 basic medicine ,Aircraft ,Airports ,Road traffic emission ,Cell Survival ,UFPs ,Cell Culture Techniques ,Bronchi ,Air–liquid interface ,Toxicology ,International airport ,Cell Line ,03 medical and health sciences ,0302 clinical medicine ,Calu-3 cell ,Ultrafine particle ,Humans ,Airport emission ,Road traffic ,Vehicle Emissions ,Air Pollutants ,Air liquid interface ,Cloud systems ,Interleukin-6 ,BMD analysis ,Cell model ,Interleukin-8 ,In vitro exposure ,High cell ,Epithelial Cells ,General Medicine ,030104 developmental biology ,030220 oncology & carcinogenesis ,Environmental chemistry ,Environmental science ,Particulate Matter ,human activities - Abstract
Relatively high concentrations of ultrafine particles (UFPs) have been observed around airports, in which aviation and road traffic emissions are the major sources. This raises concerns about the potential health impacts of airport UFPs, particularly in comparison to those emitted by road traffic. UFPs mainly derived from aviation or road traffic emissions were collected from a location near a major international airport, Amsterdam-Schiphol airport (AMS), depending on the wind direction, along with UFPs from an aircraft turbine engine at low and full thrust. Human bronchial epithelial cells (Calu-3) model in combination with an air-liquid interface (ALI) cloud system was used for the in vitro exposure to UFPs at low doses ranging from 0.09 to 2.07 μg/cm2. Particle size distribution was measured. Cell viability, cytotoxicity and inflammatory potential (interleukin (IL) 6 and 8 secretion) on Calu-3 cells were assessed after exposure for 24 h. The biological measurements on Calu-3 cells confirm that pro-inflammatory responses still can be activated at the high cell viability (> 80%) and low cytotoxicity. By the Benchmark Dose (BMD) analysis, Airport and Non-Airport (road traffic) UFPs as well as UFPs samples from a turbine engine have similar toxic properties. Our results suggest that UFPs from aviation and road traffic in airport surroundings may have similar adverse effects on public health.
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- 2020
33. Application of biological monitoring for exposure assessment following chemical incidents: A procedure for decision making
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Scheepers, Paul T J, Bos, Peter M J, Konings, Joke, Janssen, Nicole A H, and Grievink, Linda
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- 2011
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34. Challenges of exposure assessment for health studies in the aftermath of chemical incidents and disasters
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Bongers, Sim, Janssen, Nicole A H, Reiss, B, Grievink, L, Lebret, E, and Kromhout, H
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- 2008
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35. Determinants of personal and indoor PM2.5 and absorbance among elderly subjects with coronary heart disease
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Lanki, Timo, Ahokas, Anne, Alm, Sari, Janssen, Nicole A H, Hoek, Gerard, De Hartog, Jeroen J, Brunekreef, Bert, and Pekkanen, Juha
- Published
- 2007
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36. Surrounding green, air pollution, traffic noise exposure and non-accidental and cause-specific mortality
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Klompmaker, Jochem O, Hoek, Gerard, Bloemsma, Lizan D, Marra, Marten, Wijga, Alet H, van den Brink, Carolien, Brunekreef, Bert, Lebret, Erik, Gehring, Ulrike, Janssen, Nicole A H, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), IRAS OH Epidemiology Microbial Agents, Dep IRAS, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-I&I RA, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), IRAS OH Epidemiology Microbial Agents, and Dep IRAS
- Subjects
Adult ,Male ,Traffic-Related Pollution ,010504 meteorology & atmospheric sciences ,NDVI ,PM(2.5) ,Noise/adverse effects ,Air pollution ,NO(2) ,Netherlands/epidemiology ,PM2.5 ,010501 environmental sciences ,Environment ,medicine.disease_cause ,NO2 ,01 natural sciences ,Normalized Difference Vegetation Index ,Environmental health ,80 and over ,medicine ,Air Pollutants/adverse effects ,Humans ,Mortality ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,Netherlands ,Aged ,lcsh:GE1-350 ,Aged, 80 and over ,Air Pollutants ,Traffic-Related Pollution/adverse effects ,Air pollutant concentrations ,business.industry ,Hazard ratio ,Traffic noise ,Cause specific mortality ,Neurodegenerative Diseases ,Environmental Exposure ,Particulates ,Middle Aged ,Accidental ,Female ,Particulate Matter ,business ,Noise ,Environmental Exposure/adverse effects - Abstract
Background: Most previous studies that investigated associations of surrounding green, air pollution or traffic noise with mortality focused on single exposures. Objectives: The aim of this study was to evaluate combined associations of long-term residential exposure to surrounding green, air pollution and traffic noise with total non-accidental and cause-specific mortality. Methods: We linked a national health survey (Public Health Monitor, PHM) conducted in 2012 to the Dutch longitudinal mortality database. Subjects of the survey who were 30 years or older on 1 January 2013 (n = 339,633) were followed from 1 January 2013 till 31 December 2017. We used Cox proportional hazard models to evaluate associations of residential surrounding green (including the average Normalized Difference Vegetation Index (NDVI) in buffers of 300 m and 1000 m), annual average air pollutant concentrations (including particulate matter (PM10, PM2.5), nitrogen dioxide (NO2)) and traffic noise with non-accidental, circulatory disease, respiratory disease, lung cancer and neurodegenerative disease mortality. Results: We observed 26,886 non-accidental deaths over 1.627.365 person-years of follow-up. Surrounding green, air pollution and traffic noise exposure were not significantly associated with non-accidental or cause-specific mortality. For non-accidental mortality, we found a hazard ratio (HR) of 0.99 (0.98, 1.01) per IQR increase in NDVI 300 m, a HR of 0.99 (95% CI: 0.97, 1.01) per IQR increase in NO2, a HR of 0.98 (0.97, 1.00) per IQR increase in PM2.5 and a HR of 0.99 (95% CI: 0.97, 1.01) per IQR increase in road-traffic noise. Analyses restricted to non-movers or excluding subjects aged 85+ years did not change the findings. Conclusion: We found no evidence for associations of long-term residential exposures to surrounding green, air pollution and traffic noise with non-accidental or cause-specific mortality in a large population based survey in the Netherlands, possibly related to the relatively short follow-up period. Keywords: NDVI, NO2, PM2.5, Traffic noise, Mortality
- Published
- 2020
37. Green space definition affects associations of green space with overweight and physical activity
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Klompmaker, Jochem O, Hoek, Gerard, Bloemsma, Lizan D, Gehring, Ulrike, Strak, Maciej, Wijga, Alet H, van den Brink, Carolien, Brunekreef, Bert, Lebret, Erik, Janssen, Nicole A H, dIRAS RA-2, One Health Chemisch, Sub RIVM, dIRAS RA-I&I RA, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, dIRAS RA-2, One Health Chemisch, Sub RIVM, dIRAS RA-I&I RA, LS IRAS EEPI ME (Milieu epidemiologie), and Dep IRAS
- Subjects
Adult ,Male ,Distance to park ,Emigrants and Immigrants ,Environment ,010501 environmental sciences ,Overweight ,Space (commercial competition) ,Logistic regression ,01 natural sciences ,Biochemistry ,Normalized Difference Vegetation Index ,Odds ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Residence Characteristics ,medicine ,Humans ,030212 general & internal medicine ,Exercise ,Aged ,Netherlands ,Surrounding greenness ,0105 earth and related environmental sciences ,General Environmental Science ,Aged, 80 and over ,Physical activity ,Confounding ,Odds ratio ,Middle Aged ,Cross-Sectional Studies ,Geography ,Population study ,Female ,medicine.symptom ,Green space exposure ,Demography - Abstract
Introduction In epidemiological studies, exposure to green space is inconsistently associated with being overweight and physical activity, possibly because studies differ widely in their definition of green space exposure, inclusion of important confounders, study population and data analysis. Objectives We evaluated whether the association of green space with being overweight and physical activity depended upon definition of greenspace. Methods We conducted a cross-sectional study using data from a Dutch national health survey of 387,195 adults. Distance to the nearest park entrance and surrounding green space, based on the Normalized Difference Vegetation Index (NDVI) or a detailed Dutch land-use database (TOP10NL), was calculated for each residential address. We used logistic regression analyses to study the association of green space exposure with being overweight and being moderately or vigorously physically active outdoors at least 150 min/week (self-reported). To study the shape of the association, we specified natural splines and quintiles. Results The distance to the nearest park entrance was not associated with being overweight or outdoor physical activity. Associations of surrounding green space with being overweight or outdoor physical activity were highly non-linear. For NDVI surrounding greenness, we observed significantly decreased odds of being overweight [300 m buffer, odds ratio (OR) = 0.88; 95% CI: 0.86, 0.91] and increased odds for outdoor physical activity [300 m buffer, OR = 1.14; 95% CI: 1.10, 1.17] in the highest quintile compared to the lowest quintile. For TOP10NL surrounding green space, associations were mostly non-significant. Associations were generally stronger for subjects living in less urban areas and for the smaller buffers. Conclusion Associations of green space with being overweight and outdoor physical activity differed considerably between different green space definitions. Associations were strongest for NDVI surrounding greenness.
- Published
- 2018
38. Development of Europe-Wide Models for Particle Elemental Composition Using Supervised Linear Regression and Random Forest
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Chen, Jie, primary, de Hoogh, Kees, additional, Gulliver, John, additional, Hoffmann, Barbara, additional, Hertel, Ole, additional, Ketzel, Matthias, additional, Weinmayr, Gudrun, additional, Bauwelinck, Mariska, additional, van Donkelaar, Aaron, additional, Hvidtfeldt, Ulla A., additional, Atkinson, Richard, additional, Janssen, Nicole A. H., additional, Martin, Randall V., additional, Samoli, Evangelia, additional, Andersen, Zorana J., additional, Oftedal, Bente M., additional, Stafoggia, Massimo, additional, Bellander, Tom, additional, Strak, Maciej, additional, Wolf, Kathrin, additional, Vienneau, Danielle, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional
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- 2020
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39. Effects of short-term exposures to ultrafine particles near an airport in healthy adults
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Lammers, Ariana, primary, Janssen, Nicole A H, additional, Boere, A John F, additional, Berger, Marieke, additional, Longo, Cristina, additional, Vijverberg, Susanne J H, additional, Neerincx, Anne H, additional, Maitland-Van Der Zee, Anke-Hilse, additional, and Cassee, Flemming R, additional
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- 2020
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40. Photometrically measured continuous personal PM2.5 exposure: Levels and correlation to a gravimetric method
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LANKI, TIMO, ALM, SARI, RUUSKANEN, JUHANI, JANSSEN, NICOLE A H, JANTUNEN, MATTI, and PEKKANEN, JUHA
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- 2002
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41. Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project.
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Jie Chen, Rodopoulou, Sophia, de Hoogh, Kees, Strak, Maciej, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, Concin, Hans, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Arthur Hvidtfeldt, Ulla, Janssen, Nicole A. H., Jöckel, Karl-Heinz, and Jørgensen, Jeanette
- Subjects
PARTICULATE matter ,CAUSES of death ,ENVIRONMENTAL health ,DESCRIPTIVE statistics ,ENVIRONMENTAL exposure ,ALGORITHMS ,LONGITUDINAL method - Abstract
BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameter =2.5 μm [fine particulate matter (PM
2.5 )] components and mortality have been reported, partly related to challenges in exposure assessment. OBJECTIVES: We investigated the associations between long-term exposure to PM2.5 ) elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 ) components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms. METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985–2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 × 100m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2 ) separately. RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2 . HRs only remained (almost) significant for RF-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m³, adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models. CONCLUSION: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RF than SLR in two-pollutant models. [ABSTRACT FROM AUTHOR]- Published
- 2021
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42. Personal Exposure to Fine Particles in Children Correlates Closely with Ambient Fine Particles
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JANSSEN, NICOLE A. H., HOEK, GERARD, HARSSEMA, HENDRIK, and BRUNEKREEF, BERT
- Published
- 1999
43. Associations of Combined Exposures to Surrounding Green, Air Pollution, and Road Traffic Noise with Cardiometabolic Diseases
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Klompmaker, Jochem O., primary, Janssen, Nicole A. H., additional, Bloemsma, Lizan D., additional, Gehring, Ulrike, additional, Wijga, Alet H., additional, van den Brink, Carolien, additional, Lebret, Erik, additional, Brunekreef, Bert, additional, and Hoek, Gerard, additional
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- 2019
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44. Air Pollution and Mortality in Seven Million Adults: The Dutch Environmental Longitudinal Study (DUELS)
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Fischer, Paul H, Marra, Marten, Ameling, Caroline B, Hoek, Gerard, Beelen, Rob, de Hoogh, Kees, Breugelmans, Oscar, Kruize, Hanneke, Janssen, Nicole A H, Houthuijs, Danny, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA2
- Subjects
Adult ,Male ,Longitudinal study ,Pediatrics ,medicine.medical_specialty ,Lung Neoplasms ,Health, Toxicology and Mutagenesis ,Nitrogen Dioxide ,Respiratory Tract Diseases ,Population ,Air pollution ,medicine.disease_cause ,Cohort Studies ,Air pollutants ,Air Pollution ,Environmental health ,medicine ,Humans ,Longitudinal Studies ,education ,Aged ,Netherlands ,Air Pollutants ,education.field_of_study ,Research ,Incidence ,Incidence (epidemiology) ,Public Health, Environmental and Occupational Health ,Middle Aged ,Geography ,Cardiovascular Diseases ,Regression Analysis ,Female ,Particulate Matter ,Cohort study - Abstract
Background Long-term exposure to air pollution has been associated with mortality in urban cohort studies. Few studies have investigated this association in large-scale population registries, including non-urban populations. Objectives The aim of the study was to evaluate the associations between long-term exposure to air pollution and nonaccidental and cause-specific mortality in the Netherlands based on existing national databases. Methods We used existing Dutch national databases on mortality, individual characteristics, residence history, neighborhood characteristics, and national air pollution maps based on land use regression (LUR) techniques for particulates with an aerodynamic diameter ≤ 10 μm (PM10) and nitrogen dioxide (NO2). Using these databases, we established a cohort of 7.1 million individuals ≥ 30 years of age. We followed the cohort for 7 years (2004–2011). We applied Cox proportional hazard models adjusting for potential individual and area-specific confounders. Results After adjustment for individual and area-specific confounders, for each 10-μg/m3 increase, PM10 and NO2 were associated with nonaccidental mortality [hazard ratio (HR) = 1.08; 95% CI: 1.07, 1.09 and HR = 1.03; 95% CI: 1.02, 1.03, respectively], respiratory mortality (HR = 1.13; 95% CI: 1.10, 1.17 and HR = 1.02; 95% CI: 1.01, 1.03, respectively), and lung cancer mortality (HR = 1.26; 95% CI: 1.21, 1.30 and HR = 1.10 95% CI: 1.09, 1.11, respectively). Furthermore, PM10 was associated with circulatory disease mortality (HR = 1.06; 95% CI: 1.04, 1.08), but NO2 was not (HR = 1.00; 95% CI: 0.99, 1.01). PM10 associations were robust to adjustment for NO2; NO2 associations remained for nonaccidental mortality and lung cancer mortality after adjustment for PM10. Conclusions Long-term exposure to PM10 and NO2 was associated with nonaccidental and cause-specific mortality in the Dutch population of ≥ 30 years of age. Citation Fischer PH, Marra M, Ameling CB, Hoek G, Beelen R, de Hoogh K, Breugelmans O, Kruize H, Janssen NA, Houthuijs D. 2015. Air pollution and mortality in seven million adults: the Dutch Environmental Longitudinal Study (DUELS). Environ Health Perspect 123:697–704; http://dx.doi.org/10.1289/ehp.1408254
- Published
- 2015
45. The impact of particle filtration on indoor air quality in a classroom near a highway
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van der Zee, Saskia C, Strak, Maciej, Dijkema, Marieke B A, Brunekreef, Bert, Janssen, Nicole A H, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, and LS IRAS EEPI ME (Milieu epidemiologie)
- Subjects
Environmental Engineering ,010504 meteorology & atmospheric sciences ,medicine.medical_treatment ,education ,Particle (ecology) ,Pilot Projects ,010501 environmental sciences ,01 natural sciences ,complex mixtures ,law.invention ,Indoor air quality ,Soot ,law ,medicine ,Humans ,Filtration ,0105 earth and related environmental sciences ,Vehicle Emissions ,Mechanical ventilation ,Air Pollutants ,Schools ,Public Health, Environmental and Occupational Health ,Environmental engineering ,Building and Construction ,Intervention studies ,Ventilation ,Filter (video) ,Air Pollution, Indoor ,Ventilation (architecture) ,Environmental science ,Particulate Matter - Abstract
A pilot study was performed to investigate whether the application of a new mechanical ventilation system with a fine F8 (MERV14) filter could improve indoor air quality in a high school near the Amsterdam ring road. PM10, PM2.5 and black carbon (BC) concentrations were measured continuously inside an occupied intervention classroom and outside the school during three sampling periods in the winter of 2013/2014. Initially, three weeks of baseline measurements were performed, with the existing ventilation system and normal ventilation habits. Next, an intervention study was performed. A new ventilation system was installed in the classroom, and measurements were performed during 8 school weeks, in alternating 2-week periods with and without the filter in the ventilation system under otherwise identical ventilation conditions. Indoor/outdoor ratios measured during the weeks with filter were compared with those measured without filter to evaluate the ability of the F8 filter to improve indoor air quality. During teaching hours, the filter reduced BC exposure by, on average, 36%. For PM10 and PM2.5, a reduction of 34% and 30% was found, respectively. This implies that application of a fine filter can reduce the exposure of schoolchildren to traffic exhaust at hot spot locations by about one-third. This article is protected by copyright. All rights reserved.
- Published
- 2017
46. Measurement of the oxidative potential of PM2.5 and its constituents: The effect of extraction solvent and filter type
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Yang, Aileen, Jedynska, Aleksandra, Hellack, Bryan, Rooter, Ingeborg, Hoek, Gerard, Brunekreef, Bert, Kuhlbusch, Thomas A. J., Cassee, Flemming R., Janssen, Nicole A. H., Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, IRAS RATIA-SIB, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, and IRAS RATIA-SIB
- Subjects
Atmospheric Science ,Diesel exhaust ,Earth & Environment ,Chemie ,Analytical chemistry ,LINING FLUID ANTIOXIDANTS ,Environment ,Dithiothreitol ,Ascorbate acid depletion ,chemistry.chemical_compound ,AMBIENT PM2.5 ,Urban Development ,Environmental Science(all) ,ABSORBENCY ,PARTICLES ,AEC - Applied Environmental Chemistry ,Molecule ,Reactivity (chemistry) ,Built Environment ,AIRBORNE PARTICULATE MATTER ,Oxidative potential ,Chemical composition ,ASSOCIATIONS ,ESR ,General Environmental Science ,DIESEL EXHAUST ,Chemistry ,Extraction (chemistry) ,AIR-POLLUTION ,Solvent ,Filter (video) ,HYDROXYL RADICAL GENERATION ,HEALTH ,EELS - Earth, Environmental and Life Sciences ,Particulate matter ,Reactive oxygen species ,DTT - Abstract
The capacity of Particulate Matter (PM) to oxidise target molecules, defined as its oxidative potential (OP), has been proposed as a biologically more relevant metric than PM mass. Different assays exist for measuring OP and their methodologies vary in the choice of extraction solvent and filter type. Little is known about the impact of extraction and filter type on reported OP. Four a-cellular assays; electron spin resonance (ESR), dithiothreitol (DTI'), ascorbate acid depletion (AA) and reductive acridinium triggering (CRAT) assay were chosen to evaluate whether these differences affect the OP measurement, the correlation between OP from different assays and the association with PM chemical composition. We analysed 15 urban 48-72 h PM2.5 samples collected on quartz and Teflon filters. The choice of extraction solvent had only a significant effect on OPDTT, while all OP measures for quartz filters were heavily attenuated. OP values derived from quartz were, however, highly correlated with those derived from Teflon. OPDTT correlated highly with OPCRAT, and OPESR correlated highly with OPAA. These correlations were affected by the choice of filter type. Correlations between OP and PM chemical composition were not affected by filter type and extraction solvent. These findings indicate that the measurement of relative OP reactivity is not greatly influenced by filter type and extraction solvent for the investigated assays. This robustness is also promising for exploratory use in monitoring and subsequent epidemiological studies. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
- Published
- 2014
47. Oxidative potential of particulate matter collected at sites with different source characteristics
- Author
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Janssen, Nicole A. H., Yang, Aileen, Strak, Maciej, Steenhof, Maaike, Hellack, Bryan, Gerlofs-Nijland, Miriam E., Kuhlbusch, Thomas, Kelly, Frank, Harrison, Roy M., Brunekreef, Bert, Hoek, Gerard, Cassee, Flemming, IRAS RATIA2, IRAS RATIA1, IRAS RATIA-SIB, LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, IRAS RATIA1, IRAS RATIA-SIB, LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI EHIA (Env.H.Imp.Assessm.), Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), and Risk Assessment of Toxic and Immunomodulatory Agents
- Subjects
STRESS ,Environmental Engineering ,Analytical chemistry ,Oxidative phosphorylation ,Animal science ,Air Pollution ,Urban background ,BACKGROUND LOCATIONS ,Traffic ,PARTICLES ,Environmental Chemistry ,Size fractions ,Particle Size ,Oxidative potential ,Waste Management and Disposal ,ESR ,Air Pollutants ,Measurement method ,Chemistry ,ELEMENTAL COMPOSITION ,Oxidation reduction ,AIR-POLLUTION ,IN-VITRO ,Particulates ,AA ,Ascorbic acid ,Pollution ,RAPTES PROJECT ,HYDROXYL RADICAL GENERATION ,Composition (visual arts) ,HEALTH ,Particulate matter ,Oxidation-Reduction ,SUBWAY ,Environmental Monitoring ,DTT - Abstract
Background: The oxidative potential (OP) of particulate matter (PM) has been proposed as a more health relevant metric than PM mass. Different assays exist for measuring OP and little is known about how the different assays compare. Aim: To assess the OP of PM collected at different site types and to evaluate differences between locations, size fractions and correlation with PM mass and PM composition for different measurement methods for OP. Methods: PM2.5 and PM10 was sampled at 5 sites: an underground station, a farm, 2 traffic sites and an urban background site. Three a-cellular assays; dithiothreitol (OPDTT), electron spin resonance (OPESR) and ascorbate depletion (OPAA) were used to characterize the OP of PM. Results: The highest OP was observed at the underground, where OP of PM10 was 30 (OPDTT) to >600 (OPESR) times higher compared to the urban background when expressed as OP/m(3) and 2-40 times when expressed as OP/mu g. For the outdoor sites, samples from the farm showed significantly lower OPESR and OPAA, whereas samples from the continuous traffic site showed the highest OP for all assays. Contrasts in OP between sites were generally larger than for PM mass and were lower for OPDTT compared to OPESR and OPAA. Furthermore, OPDTT/mu g was significantly higher in PM2.5 compared to PM10, whereas the reverse was the case for OPESR. OPESR and OPAA were highly correlated with traffic-related PM components (i.e. EC, Fe, Cu, PAHs), whereas OPDTT showed the highest correlation with PM mass and OC. Conclusions: Contrasts in OP between sites, differences in size fractions and correlation with PM composition depended on the specific OP assay used, with OPESR and OPAA showing the most similar results. This suggests that either OPESR or OPAA and OPDTT can complement each other in providing information regarding the oxidative properties of PM, which can subsequently be used to study its health effects. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
- Published
- 2014
48. Agreement of central site measurements and land use regression modeled oxidative potential of PM2.5 with personal exposure
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Yang, Aileen, Hoek, Gerard, Montagne, Denise, Leseman, Daan L A C, Hellack, Bryan, Kuhlbusch, Thomas A J, Cassee, Flemming R, Brunekreef, Bert, Janssen, Nicole A H, LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI Inhalatie Toxicologie, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA2
- Subjects
Quality Control ,Reference site ,Environmental Exposure ,Models, Theoretical ,Land use regression ,Atmospheric sciences ,Biochemistry ,Maschinenbau ,Environmental science ,Humans ,Regression Analysis ,Particulate Matter ,Oxidation-Reduction ,General Environmental Science ,Exposure assessment ,Netherlands - Abstract
Oxidative potential (OP) of ambient particulate matter (PM) has been suggested as a health-relevant exposure metric. In order to use OP for exposure assessment, information is needed about how well central site OP measurements and modeled average OP at the home address reflect temporal and spatial variation of personal OP. We collected 96-hour personal, home outdoor and indoor PM2.5 samples from 15 volunteers living either at traffic, urban or regional background locations in Utrecht, the Netherlands. OP was also measured at one central reference site to account for temporal variations. OP was assessed using electron spin resonance (OP(ESR)) and dithiothreitol (OP(DTT)). Spatial variation of average OP at the home address was modeled using land use regression (LUR) models. For both OP(ESR) and OP(DTT), temporal correlations of central site measurements with home outdoor measurements were high (R>0.75), and moderate to high (R=0.49-0.70) with personal measurements. The LUR model predictions for OP correlated significantly with the home outdoor concentrations for OP(DTT) and OP(ESR) (R=0.65 and 0.62, respectively). LUR model predictions were moderately correlated with personal OP(DTT) measurements (R=0.50). Adjustment for indoor sources, such as vacuum cleaning and absence of fume-hood, improved the temporal and spatial agreement with measured personal exposure for OP(ESR). OP(DTT) was not associated with any indoor sources. Our study results support the use of central site OP for exposure assessment of epidemiological studies focusing on short-term health effects.
- Published
- 2015
49. A national fine spatial scale land-use regression model for ozone
- Author
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Kerckhoffs, Jules, Wang, Meng, Meliefste, Kees, Malmqvist, Ebba, Fischer, Paul, Janssen, Nicole A H, Beelen, Rob, Hoek, Gerard, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI ME (Milieu epidemiologie), and Dep IRAS
- Subjects
Quality Control ,Geographic information system ,Ozone ,Meteorology ,Epidemiology ,Atmospheric sciences ,Land use regression ,Biochemistry ,Exposure ,chemistry.chemical_compound ,Nitrogen dioxide ,General Environmental Science ,Pollutant ,Spatial variation ,business.industry ,Models, Theoretical ,chemistry ,Spatial ecology ,Geographic Information Systems ,Environmental science ,Regression Analysis ,Spatial variability ,Seasons ,business ,Scale (map) - Abstract
Uncertainty about health effects of long-term ozone exposure remains. Land use regression (LUR) models have been used successfully for modeling fine scale spatial variation of primary pollutants but very limited for ozone. Our objective was to assess the feasibility of developing a national LUR model for ozone at a fine spatial scale. Ozone concentrations were measured with passive samplers at 90 locations across the Netherlands (19 regional background, 36 urban background, 35 traffic). All sites were measured simultaneously during four 2-weekly campaigns spread over the seasons. LUR models were developed for the summer average as the primary exposure and annual average using predictor variables obtained with Geographic Information Systems. Summer average ozone concentrations varied between 32 and 61 µg/m(3). Ozone concentrations at traffic sites were on average 9 µg/m(3) lower compared to regional background sites. Ozone correlated highly negatively with nitrogen dioxide and moderately with fine particles. A LUR model including small-scale traffic, large-scale address density, urban green and a region indicator explained 71% of the spatial variation in summer average ozone concentrations. Land use regression modeling is a promising method to assess ozone spatial variation, but the high correlation with NO2 limits application in epidemiology.
- Published
- 2014
50. Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project
- Author
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Steenhof, Maaike, Janssen, Nicole A. H., Strak, Maciej, Hoek, Gerard, Gosens, Ilse, Mudway, Ian S., Kelly, Frank J., Harrison, Roy M., Pieters, Raymond H. H., Cassee, Flemming R., Brunekreef, Bert, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Sub IRAS Tox ITX (immunotoxicologie), LS IRAS EEPI Inhalatie Toxicologie, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1, IRAS RATIA2, IRAS RATIA-SIB, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Sub IRAS Tox ITX (immunotoxicologie), LS IRAS EEPI Inhalatie Toxicologie, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA1, IRAS RATIA2, and IRAS RATIA-SIB
- Subjects
Male ,Health, Toxicology and Mutagenesis ,Air pollution exposure ,SHORT-TERM EXPOSURE ,Air pollution ,Toxicology ,medicine.disease_cause ,ASTHMATIC VOLUNTEERS ,chemistry.chemical_compound ,Leukocyte Count ,MARKERS ,Leukocytes ,experimental exposure ,Volunteer ,NITROGEN-DIOXIDE ,Netherlands ,oxidative potential ,Air Pollutants ,Inhalation Exposure ,Particulates ,medicine.anatomical_structure ,Environmental chemistry ,Female ,Environmental Monitoring ,Adult ,white blood cells ,Nitrogen Dioxide ,Oxidative phosphorylation ,DIESEL-EXHAUST INHALATION ,Young Adult ,Animal science ,Ozone ,White blood cell ,medicine ,Humans ,Nitrogen dioxide ,CORONARY-HEART-DISEASE ,Particle Size ,AIRBORNE PARTICULATE MATTER ,particulate matter ,Pollutant ,INFLAMMATORY RESPONSE ,RATE-VARIABILITY ,LOS-ANGELES ,Oxidative Stress ,chemistry ,volunteers ,inflammation ,Particulate Matter ,cardiovascular effects - Abstract
Studies have linked air pollution exposure to cardiovascular health effects, but it is not clear which components drive these effects. We examined the associations between air pollution exposure and circulating white blood cell (WBC) counts in humans. To investigate independent contributions of particulate matter (PM) characteristics, we exposed 31 healthy volunteers at five locations with high contrast and reduced correlations amongst pollutant components: two traffic sites, an underground train station, a farm and an urban background site. Each volunteer visited at least three sites and was exposed for 5 h with intermittent exercise. Exposure measurements on-site included PM mass and number concentration, oxidative potential (OP), elemental- and organic carbon, metals, O-3 and NO2. Total and differential WBC counts were performed on blood collected before and 2 and 18 h post-exposure (PE). Changes in total WBC counts (2 and 18 h PE), number of neutrophils (2 h PE) and monocytes (18 h PE) were positively associated with PM characteristics that were high at the underground site. These time-dependent changes reflect an inflammatory response, but the characteristic driving this effect could not be isolated. Negative associations were observed for NO2 with lymphocytes and eosinophils. These associations were robust and did not change after adjustment for a large suite of PM characteristics, suggesting an independent effect of NO2. We conclude that short-term air pollution exposure at real-world locations can induce changes in WBC counts in healthy subjects. Future studies should indicate if air pollution exposure-induced changes in blood cell counts results in adverse cardiovascular effects in susceptible individuals.
- Published
- 2014
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