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Your search keyword '"Jiang-Shan Guo"' showing total 2 results
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2 results on '"Jiang-Shan Guo"'

1. Metal-free oxidative C(sp3)–H functionalization: a facile route to quinoline formaldehydes from methyl-azaheteroarenes

Author

Jiang-Shan Guo, Li-Qun Song, Tian-Qi Shao, Qing-Guo Meng, Yuan-Yuan Sun, Wei-Zhao Weng, Kai-Xuan Liu, and Yan-Ping Zhu

Subjects
chemistry.chemical_compound, Metal free, Chemistry, Organic Chemistry, Quinoline, Surface modification, General Chemistry, Oxidative phosphorylation, Combinatorial chemistry, Catalysis
Abstract

A facile protocol for the synthesis of quinoline formaldehydes via direct oxidative C–H bonds functionalization of methyl-azaheteroarenes in the presence of I2–DMSO has been described. This method is metal-free and easy to operate. This reaction provided a convenient route for the preparation of a range of important quinoline formaldehydes.

Published
2020
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2. Facile synthesis of 1,3,4-oxadiazoles via iodine promoted oxidative annulation of methyl-azaheteroarenes and hydrazides

Author

Jiang-Shan Guo, Yan-Ping Zhu, Zhi‐Hao Shang, Zeng-Jing Li, Ji-Na Sun, Zhen-Xiao Zhang, Yuan-Yuan Sun, and Wei-Zhao Weng

Subjects
Annulation, 010405 organic chemistry, Organic Chemistry, Quinoline, chemistry.chemical_element, Substrate (chemistry), Oxidative phosphorylation, 010402 general chemistry, Iodine, 01 natural sciences, Biochemistry, Medicinal chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Functional group
Abstract

An oxidative sp3 C–H bond of methyl-azaheteroarenes protocol was reported for the synthesis of 1,3,4-oxadiazoles via [4 + 1] annulation with hydrazides. This protocol enables 1,3,4-oxadiazole and quinoline linked diheterocycles via selective oxidation of sp3 C–H bond of methyl-azaheteroarenes in the presence of I2-DMSO. The reaction has a broad substrate scope and good functional group tolerance for methyl-azaheteroarenes and hydrazides.

Published
2020
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