26 results on '"Jinghui, Ren"'
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2. RBS-YOLO: a vehicle detection algorithm based on multi-scale feature extraction.
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Jinghui Ren, Jingmin Yang, Wenjie Zhang 0003, and Kunhui Cai
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- 2024
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3. Porous Co2VO4 Nanodisk as a High-Energy and Fast-Charging Anode for Lithium-Ion Batteries
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Jinghui Ren, Zhenyu Wang, Peng Xu, Cong Wang, Fei Gao, Decheng Zhao, Shupei Liu, Han Yang, Di Wang, Chunming Niu, Yusong Zhu, Yutong Wu, Xiang Liu, Zhoulu Wang, and Yi Zhang
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Lithium-ion batteries ,Anode ,Fast-charging ,High-energy ,Cobalt vanadate oxide ,Technology - Abstract
Abstract High-energy–density lithium-ion batteries (LIBs) that can be safely fast-charged are desirable for electric vehicles. However, sub-optimal lithiation potential and low capacity of commonly used LIBs anode cause safety issues and low energy density. Here we hypothesize that a cobalt vanadate oxide, Co2VO4, can be attractive anode material for fast-charging LIBs due to its high capacity (~ 1000 mAh g−1) and safe lithiation potential (~ 0.65 V vs. Li+/Li). The Li+ diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15 × 10–10 cm2 s−1, proving Co2VO4 a promising anode in fast-charging LIBs. A hexagonal porous Co2VO4 nanodisk (PCVO ND) structure is designed accordingly, featuring a high specific surface area of 74.57 m2 g−1 and numerous pores with a pore size of 14 nm. This unique structure succeeds in enhancing Li+ and electron transfer, leading to superior fast-charging performance than current commercial anodes. As a result, the PCVO ND shows a high initial reversible capacity of 911.0 mAh g−1 at 0.4 C, excellent fast-charging capacity (344.3 mAh g−1 at 10 C for 1000 cycles), outstanding long-term cycling stability (only 0.024% capacity loss per cycle at 10 C for 1000 cycles), confirming the commercial feasibility of PCVO ND in fast-charging LIBs.
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- 2021
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4. Effect of inorganic silicate sealing treatment on corrosion behaviour for HVAF sprayed Fe-based amorphous coatings
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Jinghui Ren, Tianrun Li, Suode Zhang, Min Xu, and Jianqiang Wang
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Materials Chemistry ,Surfaces and Interfaces ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
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5. Lychee seed-derived microporous carbon for high-performance sodium-sulfur batteries
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Decheng Zhao, Shan Jiang, Sheng Yu, Jinghui Ren, Zhen Zhang, Shupei Liu, Xiang Liu, Zhoulu Wang, Yutong Wu, and Yi Zhang
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General Materials Science ,General Chemistry - Published
- 2023
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6. Core–Shell Co2VO4/Carbon Composite Anode for Highly Stable and Fast-Charging Sodium-Ion Batteries
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Di Wang, Cong Wang, Fei Gao, Yutong Wu, Hao Tang, Weishen Chu, Peng Xu, Chunming Niu, Han Yang, Xiangan Yue, Zhenyu Wang, Yi Zhang, Zhoulu Wang, Jinghui Ren, Xiang Liu, Shupei Liu, and Decheng Zhao
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Battery (electricity) ,Materials science ,chemistry ,Chemical engineering ,Composite number ,chemistry.chemical_element ,General Materials Science ,Electrochemistry ,Current density ,Carbon ,Energy storage ,Anode ,Ion - Abstract
Sodium-ion batteries (SIBs) are promising candidates for large-scale energy storage systems due to the abundance and wide distribution of sodium resources. Various solutions have been successfully applied to revolve the large-ion-size-induced battery issues at the mid-to-low current density range. However, the fast-charging properties of SIBs are still in high demand to accommodate the increasing energy needs at large to grid scales. Herein, a core-shell Co2VO4/carbon composite anode is designed to tackle the fast-charging problem of SIBs. The synergetic effect from the stable spinel structure of Co2VO4, the size of the nanospheres, and the carbon shell provide enhanced Na+ ion diffusion and electron transfer rates and outstanding electrochemical performance. With an ultrahigh current density of 5 A g-1, the Co2VO4@C anode achieved a capacity of 135.1 mAh g-1 and a >98% capacity retention after 2000 cycles through a pseudocapacitive dominant process. This study provides insights for SIB fast-charging material design and other battery systems such as lithium-ion batteries.
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- 2021
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7. Design, Synthesis and Activity Evaluation of New Phthalazinone PARP Inhibitors
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Tu Tang, Jinghui Ren, Zhenyong Yang, Xixi Chen, Jin Cai, Yuhong Wang, Huang Mingqi, Min Ji, Jia Yang, and Xiaojing Li
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Cell Survival ,Poly ADP ribose polymerase ,Poly (ADP-Ribose) Polymerase-1 ,Poly(ADP-ribose) Polymerase Inhibitors ,Piperazines ,Olaparib ,Structure-Activity Relationship ,chemistry.chemical_compound ,PARP1 ,In vivo ,Cell Line, Tumor ,Drug Discovery ,Humans ,Polymerase ,Binding Sites ,biology ,General Chemistry ,General Medicine ,In vitro ,Molecular Docking Simulation ,Biochemistry ,chemistry ,Drug Design ,PARP inhibitor ,biology.protein ,Phthalazines ,Lead compound - Abstract
Poly(ADP-ribose)polymerase (PARP) is a significant therapeutic target for the treatment of numerous human diseases. Olaparib has been approved as a PARP inhibitor. In this paper, a series of new compounds were designed and synthesized with Olaparib as the lead compound. In order to evaluate the inhibitory activities against PARP1 of the synthesized compounds, in vitro PARP1 inhibition assay and intracellular PARylation assay were conducted. The results showed that the inhibitory activities of the derivatives were related to the type of substituent and the length of alkyl chain connecting the aromatic ring. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT)-based assay also proved that these compounds demonstrating strong inhibition to PARP1 also have high anti-proliferative activities against BRCA2-deficient cell line (Capan-1). Analysis of the entire results suggest that compound 23 with desirable inhibitory efficiency may hold promise for further in vivo exploration of PARP inhibition.
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- 2021
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8. Performance Evaluation of NIPT in Detection of Chromosomal Copy Number Variants Using Low-Coverage Whole-Genome Sequencing of Plasma DNA.
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Hongtai Liu, Ya Gao, Zhiyang Hu, Linhua Lin, Xuyang Yin, Jun Wang, Dayang Chen, Fang Chen, Hui Jiang, Jinghui Ren, and Wei Wang
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Medicine ,Science - Abstract
The aim of this study was to assess the performance of noninvasively prenatal testing (NIPT) for fetal copy number variants (CNVs) in clinical samples, using a whole-genome sequencing method.A total of 919 archived maternal plasma samples with karyotyping/microarray results, including 33 CNVs samples and 886 normal samples from September 1, 2011 to May 31, 2013, were enrolled in this study. The samples were randomly rearranged and blindly sequenced by low-coverage (about 7M reads) whole-genome sequencing of plasma DNA. Fetal CNVs were detected by Fetal Copy-number Analysis through Maternal Plasma Sequencing (FCAPS) to compare to the karyotyping/microarray results. Sensitivity, specificity and were evaluated.33 samples with deletions/duplications ranging from 1 to 129 Mb were detected with the consistent CNV size and location to karyotyping/microarray results in the study. Ten false positive results and two false negative results were obtained. The sensitivity and specificity of detection deletions/duplications were 84.21% and 98.42%, respectively.Whole-genome sequencing-based NIPT has high performance in detecting genome-wide CNVs, in particular >10Mb CNVs using the current FCAPS algorithm. It is possible to implement the current method in NIPT to prenatally screening for fetal CNVs.
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- 2016
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9. Fe2VO4 nanoparticles on rGO as anode material for high-rate and durable lithium and sodium ion batteries
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Decheng Zhao, Zhen Zhang, Jinghui Ren, Yuanyuan Xu, Xiangyu Xu, Jian Zhou, Fei Gao, Hao Tang, Shupei Liu, Zhoulu Wang, Di Wang, Yutong Wu, Xiang Liu, and Yi Zhang
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
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10. Porous Co2VO4 Nanodisk as a High-Energy and Fast-Charging Anode for Lithium-Ion Batteries
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Di Wang, Chunming Niu, Shupei Liu, Xiang Liu, Jinghui Ren, Peng Xu, Cong Wang, Yutong Wu, Yusong Zhu, Decheng Zhao, Zhenyu Wang, Han Yang, Fei Gao, Yi Zhang, and Zhoulu Wang
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Lithium-ion batteries ,Technology ,Materials science ,Cobalt vanadate oxide ,Diffusion ,Oxide ,chemistry.chemical_element ,Anode ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,High-energy ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Specific surface area ,Lithium ,Electrical and Electronic Engineering ,Porosity ,Capacity loss ,Cobalt ,Fast-charging - Abstract
High-energy–density lithium-ion batteries (LIBs) that can be safely fast-charged are desirable for electric vehicles. However, sub-optimal lithiation potential and low capacity of commonly used LIBs anode cause safety issues and low energy density. Here we hypothesize that a cobalt vanadate oxide, Co2VO4, can be attractive anode material for fast-charging LIBs due to its high capacity (~ 1000 mAh g−1) and safe lithiation potential (~ 0.65 V vs. Li+/Li). The Li+ diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15 × 10–10 cm2 s−1, proving Co2VO4 a promising anode in fast-charging LIBs. A hexagonal porous Co2VO4 nanodisk (PCVO ND) structure is designed accordingly, featuring a high specific surface area of 74.57 m2 g−1 and numerous pores with a pore size of 14 nm. This unique structure succeeds in enhancing Li+ and electron transfer, leading to superior fast-charging performance than current commercial anodes. As a result, the PCVO ND shows a high initial reversible capacity of 911.0 mAh g−1 at 0.4 C, excellent fast-charging capacity (344.3 mAh g−1 at 10 C for 1000 cycles), outstanding long-term cycling stability (only 0.024% capacity loss per cycle at 10 C for 1000 cycles), confirming the commercial feasibility of PCVO ND in fast-charging LIBs. Highlights: 1 The Li+ diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15 × 10–10 cm2 s−1, theoretically proving Co2VO4 a promising anode in fast-charging lithium-ion batteries.2 A hexagonal porous Co2VO4 nanodisk (PCVO ND) structure is designed, featuring a high specific surface area of 74.57 m2 g−1 and numerous pores with a pore size of 14 nm.3 The PCVO ND shows excellent fast-charging performance (a high average capacity of 344.3 mAh g−1 at 10 C for 1000 cycles with only 0.024% capacity loss per cycle for 1000 cycles).
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- 2021
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11. Rational design of ZnMn2O4 nanoparticles on carbon nanotubes for high-rate and durable aqueous zinc-ion batteries
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Fei Gao, Bing Mei, Xiangyu Xu, Jinghui Ren, Decheng Zhao, Zhen Zhang, Zhoulu Wang, Yutong Wu, Xiang Liu, and Yi Zhang
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2022
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12. Porous Co
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Jinghui, Ren, Zhenyu, Wang, Peng, Xu, Cong, Wang, Fei, Gao, Decheng, Zhao, Shupei, Liu, Han, Yang, Di, Wang, Chunming, Niu, Yusong, Zhu, Yutong, Wu, Xiang, Liu, Zhoulu, Wang, and Yi, Zhang
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High-energy ,Lithium-ion batteries ,Cobalt vanadate oxide ,Article ,Anode ,Fast-charging - Abstract
The Li+ diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15 × 10–10 cm2 s−1, theoretically proving Co2VO4 a promising anode in fast-charging lithium-ion batteries.A hexagonal porous Co2VO4 nanodisk (PCVO ND) structure is designed, featuring a high specific surface area of 74.57 m2 g−1 and numerous pores with a pore size of 14 nm.The PCVO ND shows excellent fast-charging performance (a high average capacity of 344.3 mAh g−1 at 10 C for 1000 cycles with only 0.024% capacity loss per cycle for 1000 cycles). Supplementary Information The online version contains supplementary material available at 10.1007/s40820-021-00758-5., High-energy–density lithium-ion batteries (LIBs) that can be safely fast-charged are desirable for electric vehicles. However, sub-optimal lithiation potential and low capacity of commonly used LIBs anode cause safety issues and low energy density. Here we hypothesize that a cobalt vanadate oxide, Co2VO4, can be attractive anode material for fast-charging LIBs due to its high capacity (~ 1000 mAh g−1) and safe lithiation potential (~ 0.65 V vs. Li+/Li). The Li+ diffusion coefficient of Co2VO4 is evaluated by theoretical calculation to be as high as 3.15 × 10–10 cm2 s−1, proving Co2VO4 a promising anode in fast-charging LIBs. A hexagonal porous Co2VO4 nanodisk (PCVO ND) structure is designed accordingly, featuring a high specific surface area of 74.57 m2 g−1 and numerous pores with a pore size of 14 nm. This unique structure succeeds in enhancing Li+ and electron transfer, leading to superior fast-charging performance than current commercial anodes. As a result, the PCVO ND shows a high initial reversible capacity of 911.0 mAh g−1 at 0.4 C, excellent fast-charging capacity (344.3 mAh g−1 at 10 C for 1000 cycles), outstanding long-term cycling stability (only 0.024% capacity loss per cycle at 10 C for 1000 cycles), confirming the commercial feasibility of PCVO ND in fast-charging LIBs. Supplementary Information The online version contains supplementary material available at 10.1007/s40820-021-00758-5.
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- 2021
13. Hierarchically Porous Carbon from Lychee Seed as Cathode Host for Fast‐Charging and High Area Capacity Li–Se Batteries
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Peng Xu, Decheng Zhao, Shupei Liu, Jinghui Ren, Jian Zhou, Ning Wang, Zhoulu Wang, Xiang Liu, Yutong Wu, and Yi Zhang
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General Energy - Published
- 2022
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14. Research Reflections on SPOC Based Teaching Model and Practice in Chinese College English Education (2014-2020)
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Jinghui Ren
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College English ,Terminal (electronics) ,Computer science ,business.industry ,Big data ,Mathematics education ,Teaching mode ,Turning point ,Diversification (marketing strategy) ,business - Abstract
This research takes a systematic investigation about recent publications on domestic SPOC based teaching models and practice in Chinese College English Education from 2014 to 2020. It discovers that the year of 2018 was supposed to be a turning point and the year of 2019 made both quantitative and qualitative changes. Plus, non-empirical studies have widened the gap with empirical researches since 2015. In addition, the research area showed a tendency of diversification, such as blended teaching, design of teaching mode, movable terminal, and learners’ factor.
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- 2020
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15. Covalent Bonding of Si Nanoparticles on Graphite Nanosheets as Anodes for Lithium-Ion Batteries Using Diazonium Chemistry
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Yi Zhang, Yusong Zhu, Jinghui Ren, Tao Xu, Guanglei Wu, Ailing Feng, Nengfei Yu, Zhengyong Huang, Yingbin Xia, and Kai Hu
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anode ,Silicon ,graphite nanosheets ,General Chemical Engineering ,Composite number ,chemistry.chemical_element ,Nanoparticle ,silicon ,Electrochemistry ,Article ,Anode ,Chemical engineering ,chemistry ,General Materials Science ,Lithium ,diazotization reaction ,Graphite ,Carbon - Abstract
Silicon/carbon (Si/C) composite has been proven to be an effective method of enhancing the electrochemical performance of Si-based anodes for lithium-ion batteries (LIBs). However, the practical application of Si/C materials in LIBs is difficult because of the weak interaction between Si and C. In this study, we applied two-step diazotization reactions to modify graphite nanosheets (GNs) and Si nanoparticles (Si NPs), yielding a stable Si&ndash, Ar&ndash, GNs composite. Owing to aryl (Ar) group bonding, Si NPs were dispersed well on the GNs. The as-prepared Si&ndash, GNs composite delivered an initial reversible capacity of 1174.7 mAh·, g&minus, 1 at a current density of 100 mAh·, 1. Moreover, capacity remained at 727.3 mAh·, 1 after 100 cycles, showing improved cycling performance. This synthesis strategy can be extended to prepare other Si/C anode materials of LIBs.
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- 2019
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16. A sandwich-like Si/SiC/nanographite sheet as a high performance anode for lithium-ion batteries
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Zhengyong Huang, Kai Hu, Guanglei Wu, Yi Zhang, Zirui Jia, Nengfei Yu, Ailing Feng, Jinghui Ren, and Yuping Wu
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Nanocomposite ,Materials science ,Silicon ,010405 organic chemistry ,Nanoparticle ,chemistry.chemical_element ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,Anode ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Silicon carbide ,Lithium ,Carbon - Abstract
Silicon/carbon (Si/C) nanocomposite anodes have attracted great interest for their use in lithium-ion batteries (LIBs). However, Si nanoparticles are difficult to stabilize on a carbon surface. Herein, we solve this stabilization problem by designing a Si/silicon carbide/nanographite sheet (Si/SiC/NanoG) nanocomposite. The Si/SiC/NanoG nanocomposite is synthesized by the magnesium thermal reduction of a mixture of silica (SiO2) nanoparticles and NanoG at low temperature, which results in a sandwich-like structure in which the middle SiC layer serves as a linker to stabilize the Si nanoparticles on the surface of NanoGs. Electrochemical characterization shows that the Si/SiC/NanoG nanocomposite anode exhibits outstanding electrochemical performance (an initial reversible capacity of 1135.4 mA h g−1 and 80.4% capacity retention after 100 cycles at 100 mA g−1). This high capacity retention is due to the strong connection between Si and NanoG through the interfacial SiC layer, which buffers the volume changes during the Li–Si alloying–dealloying process. This research will contribute to the design of advanced Si/C anode materials of LIBs.
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- 2019
17. Design, synthesis and biological evaluation of hypolipidemic compounds based on BRD4 inhibitor RVX-208
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Ning Yao, Min Ji, Yu Ping, Liu Wenjing, Jin Cai, Jinghui Ren, Hu Xinyi, Huang Mingqi, Wang Yingying, and Lili Wei
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BRD4 ,Clinical Biochemistry ,Pharmaceutical Science ,Cell Cycle Proteins ,RVX 208 ,Pharmacology ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Drug Discovery ,medicine ,Humans ,Molecular Biology ,Biological evaluation ,Hypolipidemic Agents ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Cancer ,medicine.disease ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Design synthesis ,Molecular Medicine ,Pharmacophore ,Hypolipidemic Drugs ,Transcription Factors - Abstract
Bromodomain-containing protein 4 (BRD4) is a new therapeutic target for the treatment of diseases including cardiovascular diseases, cancer, inflammation and central nervous system (CNS) disorders. In this study, we introduced the pharmacophore of fibrates to a BRD4 inhibitor, RVX-208, to design dual-active hypolipidemic compounds, and found that some of new analogues showed favorable hypolipidemic activities. Synthetic accessibility towards this class of compounds optimized RVX-208 as well as would supply more thoughts on hypolipidemic drugs.
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- 2019
18. Design, synthesis and evaluation of a novel metal chelator as multifunctional agents for the treatment of Alzheimer's disease
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Jinghui Ren, Ning Yao, Wang Yingying, Yang Yue, Jin Cai, Kwon Ho Hong, Min Ji, and Yu Ping
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Models, Molecular ,Antioxidant ,Cell Survival ,medicine.medical_treatment ,Pharmacology ,01 natural sciences ,Biochemistry ,Metal Chelator ,PC12 Cells ,chemistry.chemical_compound ,Structure-Activity Relationship ,Picrates ,Alzheimer Disease ,Coordination Complexes ,Drug Discovery ,medicine ,Animals ,Chelation ,Cytotoxicity ,Molecular Biology ,Cholinesterase ,Chelating Agents ,Amyloid beta-Peptides ,biology ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Organic Chemistry ,Biphenyl Compounds ,Free Radical Scavengers ,Hydrogen Peroxide ,Acetylcholinesterase ,In vitro ,0104 chemical sciences ,Rats ,010404 medicinal & biomolecular chemistry ,Neuroprotective Agents ,chemistry ,Tacrine ,Drug Design ,biology.protein ,Cattle ,Cholinesterase Inhibitors ,medicine.drug - Abstract
A series of compounds following the lead compounds including deferasirox and tacrine were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease (AD). In vitro studies showed that most synthesized compounds exhibited good multifunctional activities in inhibiting acetylcholinesterase (bAChE), and chelating metal ions. Especially, compound TDe demonstrated significant metal chelating property, a moderate acetylcholinesterase (AChE) inhibitory activity and an antioxidant activity. Results from the molecular modeling indicated that TD compounds were mixed-type inhibitor, binding simultaneously to the catalytic anionic site (CAS) and the peripheral anionic site (PAS) of TcAChE. Moreover, TDe showed a low cytotoxicity but a good protective activity against the injury caused by H2O2. These results suggest that TD compounds might be considered as attractive multi-target cholinesterase inhibitor and will play important roles in the treatment of AD.
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- 2018
19. Mechanical and Metallurgical Properties of Heavy Wall Grade X80 High Strain Line Pipe Steel
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Runsheng Zhang, lei Zhang, Weihua Sun, Ping Du, Zhigang Liu, Liwei Liu, Jinghui Ren, and Chaohai Guo
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business.product_category ,Materials science ,Bainite ,business.industry ,Metallurgy ,Welding ,engineering.material ,Microstructure ,law.invention ,Coating ,law ,Natural gas ,Ferrite (iron) ,Hardening (metallurgy) ,engineering ,Pipe ,Composite material ,business - Abstract
Mechanical and metallurgical properties of a 27mm thick Grade X80 steel plate and its UOE pipe are described in this paper. The steel is economically designed for its chemical compositions. Steel plates were produced by Thermal-mechanical processing (TMCP) with attentive reduction control during hot rolling stage. The microstructure is composed of multi-phases in which polygonal ferrite and granular bainite are the principal constituents. Line pipes of 1219mm outer diameter, which has strain based design for long distance natural gas transportation over the permafrost and seismic areas, were manufactured by the UOE process under a 0.8% expanding ratio on the pipe. Mechanical properties of the pipe and in the girth weld joints comply well with the pipeline construction requirement. Precipitation behaviors were analyzed in the steel materials, and a strengthening contribution at about 45.6 MPa is disclosed. Dislocation hardening in the pipe base materials after the simulating coating gives rise to 44.9 MPa.
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- 2015
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20. Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors
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Lijian Zhao, Jianhong Xie, Fuman Jiang, Yi Guo, Zhiying Gao, Hua Hu, Weipeng Wang, Yulin Zhou, Fang Chen, Jiansheng Xie, Wei Wang, Yali Li, Xiuqing Zhang, Xiaohong Zhang, Hefeng Huang, Weihua Zhao, Jun Wang, Tao Duan, Songgang Li, Shan Dan, Mei Zhong, Yue Su, Jinghui Ren, Linhua Lin, Haiyan Zhu, Jiangxia Cao, Hui Jiang, Qiufang Zhang, Jian Wang, Luming Sun, Shixiu Liao, Hongyun Zhang, Rong Qiang, Hong Yao, Yingrui Li, Tze Kin Lau, and Zhengfeng Xu
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Gynecology ,Fetus ,medicine.medical_specialty ,Pregnancy ,Massive parallel sequencing ,business.industry ,Obstetrics ,Maternal Serum Screening Tests ,Obstetrics and Gynecology ,medicine.disease ,Clinical trial ,Medicine ,Young adult ,business ,Trisomy ,Prospective cohort study ,Genetics (clinical) - Abstract
Objective To report the performance of massively parallel sequencing (MPS) based prenatal noninvasive fetal trisomy test based on cell-free DNA sequencing from maternal plasma in a routine clinical setting in China. Method The MPS-based test was offered as a prenatal screening test for trisomies 21 and 18 to pregnant women in 49 medical centers over 2years. A total of 11263 participants were recruited and the MPS-based test was performed in 11105 pregnancies. Fetal outcome data were obtained after the expected date of confinement. Results One hundred ninety cases were classified as positive, including 143 cases of trisomy 21 and 47 cases of trisomy 18. With the karyotyping results and the feed back of fetal outcome data, we observed one false positive case of trisomy 21, one false positive case of trisomy 18 and no false negative cases, indicating 100% sensitivity and 99.96% specificity for the detection of trisomies 21 and 18. Conclusion Our large-scale multicenter study proved that the MPS-based test is of high sensitivity and specificity in detecting fetal trisomies 21 and 18. The introduction of this screening test into a routine clinical setting could avoid about 98% of invasive prenatal diagnostic procedures. © 2012 John Wiley & Sons, Ltd. Supporting information may be found in the online version of this article.
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- 2012
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21. Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies
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Shengpei Chen, Hongyun Zhang, Jiansheng Xie, Baomin Yin, Hui Guo, Jun-Jun Wang, Hui-Hui Jiang, Yue Su, Wei-wei Wang, Xianghua Chai, Huakun Zhang, Zhongming Tian, Wei-Mou Zheng, Jianhong Xie, Songgang Li, Lifu Liu, Qiyun Li, Yuying Yuan, Shan Dan, Huifei Chen, Xiuqing Zhang, Wen Su, Yihan Li, Linhua Lin, Yuqiu Zhou, Jian Wang, Fang-Fang Chen, Fuman Jiang, Zhaoling Xuan, Yingrui Li, Chunlei Zhang, Xiaoyu Pan, Jinghui Ren, Lijian Zhao, Zhengyu Zhang, and Peipei Li
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Adult ,Quality Control ,Autosomal aneuploidies ,medicine.medical_specialty ,Down syndrome ,lcsh:Internal medicine ,Massively parallel sequencing ,lcsh:QH426-470 ,Ultrasound scan ,Aneuploidy ,Prenatal diagnosis ,Chromosome Disorders ,Sex chromosomal aneuploidies ,Biology ,Young Adult ,Fetus ,Bias ,Pregnancy ,Prenatal Diagnosis ,medicine ,Genetics ,Humans ,Genetics(clinical) ,lcsh:RC31-1245 ,Genetics (clinical) ,Base Composition ,Sex Chromosomes ,Obstetrics ,Noninvasive Fetal Trisomy (NIFTY) test ,Computational Biology ,DNA ,Sequence Analysis, DNA ,Middle Aged ,medicine.disease ,lcsh:Genetics ,Cell-free fetal DNA ,Technical Advance ,Female ,Down Syndrome ,Trisomy - Abstract
Background Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy. Methods We developed an advanced noninvasive prenatal diagnosis method based on massively parallel sequencing. The Noninvasive Fetal Trisomy (NIFTY) test, combines an optimized Student’s t-test with a locally weighted polynomial regression and binary hypotheses. We applied the NIFTY test to 903 pregnancies and compared the diagnostic results with those of full karyotyping. Results 16 of 16 trisomy 21, 12 of 12 trisomy 18, two of two trisomy 13, three of four 45, X, one of one XYY and two of two XXY abnormalities were correctly identified. But one false positive case of trisomy 18 and one false negative case of 45, X were observed. The test performed with 100% sensitivity and 99.9% specificity for autosomal aneuploidies and 85.7% sensitivity and 99.9% specificity for sex chromosomal aneuploidies. Compared with three previously reported z-score approaches with/without GC-bias removal and with internal control, the NIFTY test was more accurate and robust for the detection of both autosomal and sex chromosomal aneuploidies in fetuses. Conclusion Our study demonstrates a powerful and reliable methodology for noninvasive prenatal diagnosis.
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- 2011
22. Prenatal diagnosis and molecular cytogenetic analysis of a de novo isodicentric chromosome 18
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Yong Dai, Yanliang Zhang, Jinghui Ren, and Linqian Wang
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Genetics ,Adult ,congenital, hereditary, and neonatal diseases and abnormalities ,Derivative chromosome ,Marker chromosome ,Breakpoint ,Prenatal diagnosis ,Karyotype ,Case Report ,General Medicine ,Biology ,Molecular biology ,Ultrasonography, Prenatal ,Telomere ,Chromosome 18 ,Pregnancy ,Karyotyping ,Humans ,Abnormalities, Multiple ,Female ,Chromosomes, Human, Pair 18 ,Comparative genomic hybridization - Abstract
Isodicentric chromosome 18 [idic(18)] is rare structural aberration. We report on a prenatal case described by conventional and molecular cytogenetic analyses. The sonography at 24 weeks of gestation revealed multiple fetal anomalies; radial aplasia and ventricular septal defect were significant features. Routine karyotyping showed a derivative chromosome replacing one normal chromosome 18. The parental karyotypes were normal, indicating that the derivative chromosome was de novo. Array comparative genomic hybridization (array-CGH) revealed 18p11.21→qter duplication and 18p11.21→pter deletion for genomic DNA of the fetus. The breakpoint was located at 18p11.21 (between 12104527 bp and 12145199 bp from the telomere of 18p). Thus, the derivative chromosome was ascertained as idic(18)(qter→p11.21::p11.21→qter). Fluorescent in situ hybridization (FISH) confirmed that the derivative chromosome was idic(18). Our report describes a rare isodicentric chromosome 18 and demonstrates that array-CGH is a useful complementary tool to cytogenetic analysis for reliable identifying derivative chromosome.
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- 2010
23. Mandibulofacial dysostosis, microtia, and limb anomalies in a newborn: a new form of acrofacial dysostosis syndrome?
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Yang Liu, Jinghui Ren, Ying Zhang, and Yong Dai
- Subjects
Genetics ,Candidate gene ,Comparative Genomic Hybridization ,Craniofacial Dysostosis ,Microtia ,Infant, Newborn ,Limb Deformities, Congenital ,Dysostosis ,Ear ,Syndrome ,Biology ,medicine.disease ,Dysostoses ,Gene dosage ,Congenital Abnormalities ,Miller syndrome ,medicine ,Humans ,Abnormalities, Multiple ,Copy-number variation ,Genetics (clinical) ,Mandibulofacial Dysostosis ,Comparative genomic hybridization ,Congenital Microtia - Abstract
The acrofacial dysostoses (AFDs) are a heterogeneous group of disorders involving craniofacial dysostosis and limb anomalies. Depending on the type of limb defects, two major groups have been defined: Nager syndrome with predominant preaxial anomalies and Miller syndrome with postaxial malformations. Genomic copy number variation, a common type of genomic variability, can influence gene expression by disrupting coding sequences, perturbing long-range gene regulation, or altering gene dosage, and these effects could contribute to phenotypic variations or disease risk. We present a distinct AFD case with mandibulofacial dysostosis, microtia and limb malformations but without limb defects, which may represent a new form of AFD. To investigate the etiology of the phenotype, whole genomic high-resolution array comparative genomic hybridization analysis was carried out, revealing two cryptic duplications, 1p36.33 and 1q21.3-q22 duplications. Two genes, VWA1 and PYGO2, contained in the two duplications, respectively, are likely to be the candidate genes for the phenotype of our patient.
- Published
- 2010
24. [A recurrent rhodopsin gene missense mutation in a Chinese family with autosomal dominant retinitis pigmentosa]
- Author
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Shayan, Wang, Ruanzhang, Zhang, Zhilin, Shi, Lili, Ren, and Jinghui, Ren
- Subjects
Adult ,Family Health ,Male ,China ,Rhodopsin ,Adolescent ,Base Sequence ,DNA Mutational Analysis ,Mutation, Missense ,Middle Aged ,Polymerase Chain Reaction ,Pedigree ,Humans ,Female ,Retinitis Pigmentosa - Abstract
To detect mutation in the rhodopsin gene (RHO) in a Chinese family with autosomal dominant retinitis pigmentosa (ADRP).A total of 25 family members from a Chinese family were investigated. All the subjects were examined clinically by direct funduscopy, perimetry and vision test. Evaluation of the proband included electroretinography (ERG). Genomic DNA was extracted using standard method. The complete coding regions of RHO were amplified by polymerase chain reaction (PCR) and the PCR products were subjected to automatic DNA sequencing.512 CT (P171L), a recurrent missense mutation was detected in the proband. All 12 affected subjects in the family were heterozygous for the mutation. The affected individuals had night blindness at the age of 5-6 years. They had relatively severe impairment of visual acuity and suffered a gradual loss of peripheral visual field at the age of 20-30 years. And they went blind at the age of 40-50 years. Rod and cone ERG were not detectable in the proband.A recurrent missense mutation, 512CT (P171L), was detected in a Chinese family with ADRP.
- Published
- 2005
25. Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies.
- Author
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Fuman Jiang, Jinghui Ren, Fang Chen, Yuqiu Zhou, Jiansheng Xie, Shan Dan, Yue Su, Jianhong Xie, Baomin Yin, Wen Su, Huakun Zhang, Wei Wang, Xianghua Chai, Linhua Lin, Hui Guo, Qiyun Li, Peipei Li, Yuying Yuan, Xiaoyu Pan, and Yihan Li
- Subjects
- *
HYPOTHESIS , *DIAGNOSIS , *TRISOMY , *CHROMOSOMES , *PRENATAL diagnosis - Abstract
Background: Conventional prenatal screening tests, such as maternal serum tests and ultrasound scan, have limited resolution and accuracy. Methods: We developed an advanced noninvasive prenatal diagnosis method based on massively parallel sequencing. The Noninvasive Fetal Trisomy (NIFTY) test, combines an optimized Student's t-test with a locally weighted polynomial regression and binary hypotheses. We applied the NIFTY test to 903 pregnancies and compared the diagnostic results with those of full karyotyping. Results: 16 of 16 trisomy 21, 12 of 12 trisomy 18, two of two trisomy 13, three of four 45, X, one of one XYY and two of two XXY abnormalities were correctly identified. But one false positive case of trisomy 18 and one false negative case of 45, X were observed. The test performed with 100% sensitivity and 99.9% specificity for autosomal aneuploidies and 85.7% sensitivity and 99.9% specificity for sex chromosomal aneuploidies. Compared with three previously reported z-score approaches with/without GC-bias removal and with internal control, the NIFTY test was more accurate and robust for the detection of both autosomal and sex chromosomal aneuploidies in fetuses. Conclusion: Our study demonstrates a powerful and reliable methodology for noninvasive prenatal diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
26. Mining Lexical Co-occurrence Features Based Research On Construction Engineering English.
- Author
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Jinghui Ren
- Published
- 2019
- Full Text
- View/download PDF
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