1. Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening
- Author
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Teresa Téllez, Cristina Abitei, María del Carmen Padilla-Ruiz, Francisco Rivas-Ruiz, Rafael Fúnez, Teresa Pereda, Isabel Rodrigo, Julia Alcaide, María Luisa Baré, María Manuela Morales Suárez-Varela, Iñaki Zabalza, Matilde Sánchez del Charco, Juan José Borrero Martín, Raimundo García del Moral, Antonio Escobar, José María Quintana, Urko Aguirre, Maximino Redondo, José María Quintana Lopez, Marisa Baré Mañas, Maximino Redondo Bautista, Eduardo Briones Pérez de la Blanca, Nerea Fernández de Larrea Baz, Cristina Sarasqueta Eizaguirre, Antonio Escobar Martínez, Francisco Rivas Ruiz, María M. Morales-Suárez-Varela, Juan Antonio Blasco Amaro, Isabel del Cura Gonzalez, Inmaculada Arostegui Madariaga, Amaia Bilbao González, Nerea González Hernandez, Susana García-Gutiérrez, Iratxe Lafuente Guerrero, Urko Aguirre Larracoechea, Miren Orive Calzada, Josune Martin Corral, Ane Anton-Ladislao, Nuria Torà, Marina Pont, María Purificación Martínez del Prado, Alberto Loizate Totorikaguena, Ignacio Zabalza Estevez, José Errasti Alustiza, Antonio Z. Gimeno García, Santiago Lázaro Aramburu, Mercè Comas Serrano, José María Enríquez Navascues, Carlos Placer Galan, Amaia Perales, Iñaki Urkidi Valmaña, José María Erro Azkárate, Enrique Cormenzana Lizarribar, Adelaida Lacasta Muñoa, Pep Piera Pibernat, Elena Campano Cuevas, Ana Isabel Sotelo Gómez, Segundo Gómez Abril, F. Medina-Cano, Arturo Del Rey-Moreno, Manuel Jesús Alcántara, Rafael Campo, Alex Casalots, Carles Pericay, María José Gil, Miquel Pera, Pablo Collera, Josep Alfons Espinàs, Mercedes Martínez, Mireia Espallargues, Caridad Almazán, Paula Dujovne Lindenbaum, José María Fernández-Cebrián, Rocío Anula Fernández, Julio Ángel Mayol Martínez, Ramón Cantero Cid, Héctor Guadalajara Labajo, María Heras Garceau, Damián García Olmo, Mariel Morey Montalvo, Javier Mar, European Commission, Instituto de Salud Carlos III, and Red de Investigación en Servicios de Salud en Enfermedades Crónicas (España)
- Subjects
Male ,medicine.medical_specialty ,Survival ,Colorectal cancer ,Perineural invasion ,Asymptomatic ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biomarkers, Tumor ,Humans ,Mass Screening ,Medicine ,Prospective Studies ,Colorectal carcinomas ,030212 general & internal medicine ,Stage (cooking) ,Prospective cohort study ,Early Detection of Cancer ,Aged ,Neoplasm Staging ,Biological markers ,business.industry ,Incidence ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Survival Rate ,Oncology ,Spain ,030220 oncology & carcinogenesis ,Cohort ,Screening ,T-stage ,Female ,Surgery ,medicine.symptom ,Colorectal Neoplasms ,business ,Body mass index ,Follow-Up Studies - Abstract
REDISSEC-CARESS/CCR group., [Introduction] Few studies have been conducted to establish the relationship between colorectal cancer screening programmes and survival adjusting by stage and, to determine whether there are differences, at a biological level, between the tumours of asymptomatic and symptomatic patients. Accordingly, the aim of this study is to evaluate clinical, biological and survival differences between symptomatic colorectal tumours and those detected by screening., [Study method] A prospective cohort study was performed of patients subjected to surgical intervention during the period 2010–2012, at different hospitals in Spain. In every case, clinical, pathological, biological and survival-related variables were obtained., [Results] A total of 2634 patients from the CARESS-CCR cohort were analysed; of these, 220 were diagnosed through screening. The asymptomatic patients were younger, had a higher Body Mass Index (BMI), a lower degree of perineural invasion and a less advanced T stage and nodular stage, and the tumour was frequently located on the right side of the colon. All of these differences were statistically significant. The serum tumour marker carbohydrate antigen 19.9 (CA 19.9) was found more frequently in the symptomatic patients (p, [Conclusions] The detection method employed influenced the survival of patients with colorectal cancer and there were no significant biological differences between the study groups., This research was partially supported by grants from REDISSEC (RD12/0001/0010 and RD16/0001/0006), Instituto de Salud Carlos III (PI 09/00910, PI 13/00013, PI 18/01181) and the European Regional Development Fund.
- Published
- 2019