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Objective: To report case series evaluated for congenital syphilitic hepatitis. Method: Study conducted at Maternity Santa Isabel from December 2021 to May 2022. We evaluated newborns with congenital syphilis using data taken from the pregnant woman’s card, the child’s card, the anamnesis and exams performed in the follow-up consultations of these families. Complete medical records of infants who presented the criteria for the diagnosis of congenital syphilis of the Ministry of Health and the Center for Disease Transmission Control were included. Results: The review was 15 of which were selected that fit all the inclusion criteria. The babies were born with good vitality, term, one had low birth weight, six hepatomegaly, all treated with penicillin, nine had altered liver biochemical tests. At ultrasonography, Doppler was normal for all, one case of hepatosplenomegaly and one with splenomegaly. Two mothers who were diagnosed at the time of delivery had fewer than six consultations, their babies had neurosyphilis and presented developmental alertness. The child who had microcephaly and low birth weight also presented altered neurodevelopment. Of the pregnant women, three were over 30 years old, one was white, five had studied less than 8 years, thirteen were not working, family income of 1 minimum wage or less in twelve families. Eight were inadequately treated. Of the parents, eleven had studied less than 8 years and eleven were inadequately treated. Conclusion: The children with syphilis were born vigorous and had adequate treatment. Nine had altered hepatic biochemical exams, two had ultrasonographic alterations, however, without alterations in the Doppler. The children of untreated mothers had neurosyphilis and neurodevelopmental changes.

No Brasil, existe a atração turística de interagir com cavalos-marinhos, que ocorre por meio de passeios de jangada, durante os quais os animais são capturados e expostos em recipientes de vidro para serem fotografados e filmados pelos turistas. Foram monitoradas duas unidades de conservação marinhas federais onde essa atividade ocorre, o Parque Nacional de Jericoacoara (área monitorada de 600 m2), no estado do Ceará, e a Área de Proteção Ambiental (APA) Delta do Parnaíba (área monitorada de 547 m 2), no estado do Piauí. Entre 2011 e 2015, em ambas as áreas protegidas, a busca ativa de animais foi realizada por snorkeling durante a maré baixa, e a única espécie encontrada foi Hippocampus reidi, com 1286 avistamentos no Parque Nacional e 602 na APA. Resultados como a altura média na formação da bolsa incubadora do macho (11,35 e 11,52 cm na APA e Parque Nacional, respectivamente), o tamanho na primeira maturidade sexual (14,2 e 14,7 cm, respectivamente) e o período reprodutivo ao longo do ano foram muito semelhantes entre as populações das duas áreas marinhas protegidas. Todos os sítios em ambas áreas protegidas sofreram uma redução significativa na população de cavalos-marinhos durante o estudo, exceto o sítio P2, na APA, onde os números de cavalos-marinhos permaneceram estáveis ao longo do estudo. In Brazil, there is the tourist attraction of interacting with seahorses, which occurs through raft rides, during which the animals are captured and displayed in glass containers to be photographed and filmed by tourists. Two federal protected marine areas where this activity takes place were monitored, Jericoacoara National Park (monitored area of 600 m 2), in the state of Ceará, and Environmental Protection Area (EPA) Delta do Parnaíba (monitored area of 547 m2), in the stateof Piauí. Between 2011 and 2015, in both PMAs, the active search for animals was carried out by snorkeling during low tide, and the only species found was Hippocampus reidi, with 1286 sightings of seahorses in the National Park and 602 in the EPA. Results such as the mean height at formation of the male brood pouch (11.35 and 11.52 cm at EPA and National Park, respectively), size at first sexual maturity (14.2 and 14.7 cm, respectively) and reproductive period throughout the year were very similar between the populations of the two protected areas. All sites in both PMAs suffered a significant reduction in seahorse population during the study, except for the site P2 in EPA where the seahorse numbers remained stable throughout the study. En Brasil, existe el atractivo de los turistas interactuaren con los caballitos de mar durante los paseos en canoa, en los que estos animales son capturados y expuestos en recipientes de vidrio para ser fotografiados y filmados. En este estudio fueron analizados parámetros de población de los caballitos del mar en dos Unidades Federales de Conservación Marina en Brasil donde ocurre esta actividad: el Parque Nacional Jericoacoara, en Ceará (área analizada = 600 m 2), y el Área de Protección Ambiental (APA) Delta do Parnaíba, en Piauí (área analizada = 547 m 2). Entre 2011 y 2015 se realizó una búsqueda activa de caballitos de mar en ambas AMP durante la bajamar mediante buceo con esnórquel. La única especie encontrada fue Hippocampus reidi, con 1286 avistamientos en el Parque Nacional y 602 en la APA. Fueron observados resultados similares en las dos áreas protegidas en algunos parámetros investigados, como la altura media de la bolsa de cría delos machos (APA = 11,35 y Parque Nacional = 11,52 cm), la altura de los individuos en la primeramadurez sexual (APA = 14,2 y Parque Nacional = 14,7 cm) y el período reproductivo durante el año.Todos los locales en ambas áreas protegidas tuvieron una reducción significativa en la población decaballitos de mar durante el estudio, excepto un local en el APA en el cual el número de caballitos demar se mantuvo estable durante todo el estudio.

There is not a described method to count the core label of c-Fos-positive neurons, avoiding false-positive and false-negative results. The aim of this manuscript is to provide guidelines for a secure and accurate method to calculate a threshold to select which core of c-Fos-positive neurons marked by immunofluorescence has to be scored. A background percentage was calculated by dividing the intensity value (0 to 255) of the core of c-Fos-positive neurons by its surrounding background from the 8-bit images obtained in a previous study. Using the background percentage from 20% up to 98%, raising 2% once for each score, as threshold to choose which core has to be counted, a script was written for the R program to count the number of the c-Fos-positive neurons and the comparison between control and experimental groups. The differences of the average number of the core counted c-Fos-positive neurons between control and experimental groups, at all thresholds studied, showed a rising value related to an increase of the background percentage threshold as well as a decrease of its p value related to an increase of the threshold of background percentage. For the smallest thresholds (high intensity of label), the differences between groups are suppressed (false negative). However, for the biggest thresholds (nonspecific label), these differences are always the same (false positive). Therefore, to avoid the false-negative and the false-positive values, it was chosen as the threshold of 62% the inflection point of the linear regression, which is equally different from the biggest and smallest values of the differences between groups.

Objetivo: Avaliar a qualidade de vida de pessoas com diabetes mellitus seis meses após o término da participação em programa educativo. Método: estudo descritivo de abordagem quantitativa desenvolvido com 32 pessoas com diabetes mellitus acompanhadas no ambulatório de um hospital universitário de Sergipe. Para a coleta de dados foram utilizados três instrumentos, um para a caracterização sociodemográfica e clínica e dois para avaliação da qualidade de vida, o Whoqol-bref e o B-PAID. Resultados: Houve declínio da qualidade de vida, sobretudo nos domínios Relações sociais e Ambiente e aumento do sofrimento em viver com o diabetes. Foi observada correlação positiva e estatisticamente significativa entre o sexo e a medida de qualidade de vida WhoqoL-bref, com os homens tendo apresentado melhor avaliação. Conclusão: O declínio da qualidade de vida e o aumento do sofrimento em viver com o diabetes podem estar associados ao término das atividades do programa de educação em saúde.

The NOVA classification is not yet widely understood by the entire population and studies evaluating knowledge about the degree of food processing in university students are still scarce. In addition, it is unclear whether there is a difference in knowledge about the degree of food processing between academic areas in universities. Knowing that less knowledge can be a risk factor for risky eating habits, this study aims to assess the knowledge about food processing grade among university students. A cross-sectional study with 977 students. The questionnaire assessed knowledge about the degree of food processing (in natura, minimally processed, processed and ultra-processed). A linear regression analysis was used to demonstrate an association between overall knowledge about the degree of food processing and sociodemographic variables, academic areas and initial knowledge about the Brazilian food guide. The overall knowledge mean about the degree of food processing was 2.57 (1.37). The linear regression showed an association between age (p

Introdução: A esquistossomose causada pelo verme Schistosoma mansoni é uma doença de evolução grave se não tratada. Atualmente existem poucos fármacos disponíveis para o tratamento da infecção, e essa escassez compromete os objetivos de erradicação da doença. Com isso, as ferramentas in sílico têm se mostrado cada vez mais pertinentes no auxílio de descobertas de novas drogas com potencial terapêutico. Objetivo: Nessa perspectiva, o presente trabalho objetivou predizer fármacos com propriedade anti-Schistosoma e que possam ser reposicionados para o tratamento da esquistossomose mansoni. Metodologia: Foi empregado a ferramenta computacional QSAR-2D através do software Knime Analitics Platform para predizer fármacos com propriedades anti-esquistossomôticas. Essa abordagem dispõe da capacidade de aprendizado de máquina a qual realiza uma comparação entre estruturas químicas conhecidas e moléculas químicas presentes num banco de dados previamente fornecido e que são, originalmente, aplicadas ao tratamento de outras doenças. No banco de dados ChEMBL foram coletados 50 fármacos com ação anti-parasitária, utilizados para treinar o algoritmo. Para o conjunto teste, foram investigados 347 moléculas químicas com potencial terapêutico para o parasito. O modelo preditivo foi dividido em dois subconjuntos, um com validação externa (30%) e o segundo sendo o grupo teste (70%). As análises foram baseadas no modelo de regressão de Pearson por meio da aprendizagem de máquina Tree Ensemble Learner (regression), sendo considerado relevante a predição com cut-off de r2>|0,7|. Resultados: O presente modelo obteve um cut-off de r2=0,707, demonstrando relevância aceitável da predição e três fármacos demonstraram ser mais promissores. A niclosamida, o ácido meclofenâmico e o ácido flufenâmico foram apontados como compostos de potencial anti-esquistossomôtico. Dentre eles, o primeiro apresenta ação moluscicida conhecida contra os vetores do S. mansoni, o segundo contra o parasito em modelo murinho, isso demonstra confiabilidade à predição do presente modelo, e o terceiro ainda não foi testado contra o verme. Os ácidos meclofenâmico e flufenâmico são anti-inflamatórios não esteroidais (AINEs) ambos indicados no alívio de distúrbios reumáticos. Conclusão: Assim, tornar- se-á instigante testar in vitro e in vivo o ácido flufenâmico, considerando o potencial anti-esquistossomôtico que alguns outros AINEs apresentam frente ao S. mansoni visando reposicionamento de fármacos.

Background\ud Detailed information on how socio-economic characteristics are related to COVID-19 incident cases and maternal deaths is needed. We investigated the spatial distribution of COVID-19 cases and maternal deaths in Brazil and their association with social determinants of health.\ud Methods\ud This was a population-based ecological study with a spatial analysis of all cases and deaths of COVID-19 in the obstetric population. Data on COVID-19 cases and deaths in the obstetric population, social vulnerability, health inequities, and health system capacity at the municipal level were obtained from several publicly sources in Brazil. A Bayesian empirical local model was used to identify fluctuations of the indicators. Spatial statistic tests were used to identity the spatial clusters and measure the municipalities’ risk of COVID-19 in the obstetric population. Beta regression was used to characterise the association between socio-economic indicators and the burden of COVID-19.\ud Findings\ud A total of 13,858 cases and 1,396 deaths due to COVID-19 were recorded in Brazil from March 2020 to June 2021. There was a variation in the number of cases per municipality, with 105 municipalities with rates from 2,210 to 3,884 cases and 45 municipalities with rates from 3,884 to 7,418 cases per 100,000 live births. The maternal mortality ratio also varied widely across municipalities. There was a spatial dependence on smoothed maternal mortality rates (I Moran 0·10; P = 0·010), and 15 municipalities had higher risk of maternal deaths. Municipalities characterized by lower health resources and higher socioeconomic inequalities presented the highest rates of incidence and maternal mortality by COVID-19.\ud Interpretation\ud In Brazil, COVID-19 cases and deaths in the obstetric population had a heterogeneous geographical distribution, with well-defined spatial clusters mostly located in the countryside. Municipalities with a high degree of socioeconomic dissimilarities showed higher maternal mortality rates than areas with better social and infrastructure indicators.

Background Monitoring the characteristics and associated factors for death among pregnant and postpartum women with coronavirus disease 19 (COVID-19) is necessary. We investigated the clinical characteristics and risk factors associated with maternal deaths in a nationwide cohort of Brazil. Methods This was a population-based cohort of all pregnant and postpartum women hospitalised with COVID-19 notified to the Sistema de Informação de Vigilância Epidemiológica da Gripe of Brazil (SIVEP-Gripe), from February 2020 to September 2021. The primary outcome was time to in-hospital death, with risk factors analysed with univariable and multivariable Cox proportional hazards regression models. Results Cumulative observation time was 248 821 person-days from hospital admission to the end of follow-up for 15 105 individuals. There were 1858 deaths (12.3%) for a maternal mortality rate of 7.5 (95% CI 7.1–7.8) per 1000 patients-days. The cumulative mortality increased over time. Black/Brown ethnicity had a higher risk of death than women self-identifying as White. Women in the North, Northeast, Central-West and Southeast regions had higher risk of death than women in the South region. The characteristics independently associated with death were a postpartum status on admission [adjusted hazard ratio, HR 1.4 (95% confidence interval, CI 1.2–1.6)], pre-existing clinical conditions [adjusted HRs 1.2 (95%CI 1.1–1.3) for one and 1.3 (95%CI 1.1–1.5) for two comorbidities], hypoxaemia on admission [adjusted HR 1.2 (95%CI 1.1–1.4)] and requiring non-invasive [adjusted HR 2.6 (95%CI 2.1–3.3)] or invasive ventilatory support [adjusted HR 7.1 (95%CI 5.6–9.2)]. Conclusion In Brazil, the in-hospital maternal mortality rate due to COVID-19 is high and the risk of death increases with the length of hospitalisation. Socio-demographic and biological factors are associated with an increased risk of maternal death. The presence of respiratory signs and symptoms should be considered early markers of disease severity and an adequate management is necessary. Our findings reinforce the need for vaccination of pregnant and postpartum women against COVID-19.

RESUMO O objetivo deste estudo foi identificar o uso de dispositivos metodológicos para mudanças de comportamento e a prática de educação em saúde aos indivíduos com Diabetes Mellitus (DM). Estudo descritivo, exploratório, de abordagem transversal, desenvolvido no município de Aracaju, Sergipe, com 138 profissionais, médicos e enfermeiros da Estratégia Saúde da Família, utilizando entrevista estruturada, tendo como referencial teórico-metodológico o Modelo de Atenção à Condição Crônica. Os resultados mostraram que a maioria dos profissionais referiu desenvolver atividades de educação em saúde, sendo os temas mais referidos: alimentação saudável e exercício físico. Com relação ao uso de abordagens para mudança de comportamento dos usuários, a mais utilizada foi a entrevista motivacional, seguida do Modelo Transteórico de Mudança (MTT). Todos os profissionais que utilizam o MTT concordam com sua aplicabilidade. Conclui-se que a prática de educação em saúde para pessoas com DM é desenvolvida, enquanto o uso de dispositivos metodológicos para mudanças de comportamento ainda é subutilizado, sobretudo o Grupo Operativo. ABSTRACT The objective of this study was to identify the use of methodological devices for behavioral changes and practice of health education for individuals with Diabetes Mellitus (DM). A descriptive, exploratory, cross-sectional study developed in the city of Aracaju, Sergipe, Brazil, with 138 professionals, doctors and nurses of the Family Health Strategy, using a structured interview, having as a theoretical-methodological reference the Model of Care to Chronic Conditions. The results showed that most of the professionals referred to developing health education activities, with the most mentioned themes being: healthy eating and physical exercise. Regarding the use of approaches to change the behavior of users, the most used was the motivational interview, followed by the Transtheoretical Model of Change (MTT). All professionals who use MTT agree with its applicability. It is concluded that the practice of health education for people with DM is developed, while the use of methodological devices for behavior changes is still underutilized, especially the Operative Group.

The aim of this study was to investigate the quality of the diets consumed by patients with acute coronary syndrome (ACS) who received public and private health care.This observational, prospective, longitudinal cohort study evaluated patients with ACS who attended three private and one public cardiology reference hospitals. Information about dietary parameters during the 6 mo before the acute ACS event was collected at admission and 180 d later using a semiquantitative food frequency questionnaire. Diet quality was assessed using the Alternative Healthy Eating Index (2010), and a multilinear regression model was developed to evaluate the associated variables.The 581 volunteers included in this study comprised 325 (55.9%) and 256 (44.1%) patients treated at private and public hospitals, respectively. Although the dietary index increased significantly after ACS (P0001), diet quality remained unsatisfactory, particularly in terms of reductions in the consumption of cardioprotective components (vegetables, fruits, and eicosapentaenoic and docosahexaenoic fatty acids). Compared with patients receiving private health care, those attending a public hospital reported lower dietary quality (P0.001). The best diet quality was found to correlate with female sex (P0.001), receipt of dietary guidance at hospital discharge (P0.001), private health care (P0.001), a stable relationship status (P, 0.016), and older age (P0.001).The overall post-ACS diet quality remained unsatisfactory, especially in terms of cardioprotective components and among patients receiving public health care. Sociodemographic factors and the assistance model/quality were determinants of the observed differences in dietary quality.

Background Acute myocardial infarction (AMI), with and without ST-segment elevation (STEMI and NSTEMI, respectively), is the principal cause of cardiovascular morbidity and mortality in Brazil and around the world. Modifiable risk factors (RF) and quality of life (QOL) may correlate with the type of AMI. Objective To evaluate the influence of QOL and RF on the type of AMI and in-hospital cardiovascular events in STEMI and NSTEMI patients. Methods This was an observational, cross-sectional study. Patients with AMI attending four referral hospitals (three private and one public) for cardiovascular disease treatment were assessed for QOL using the Brazilian version of the 36-item short form survey. A p < 0.05 was considered statistically significant. Results We evaluated 480 volunteers; 51% were treated in one of the private hospitals. In total, 55.6% presented with STEMI, and 44.4% with NSTEMI. Patients from the public hospital were 8.56 times more likely to have STEMI compared to those from the private hospitals. There was a higher prevalence of smokers in STEMI (p < 0.028) patients. QOL was not associated with the type of AMI. A negative patient perception of the physical health and pain domains was observed. Although a significant difference between the physical and the mental health domains was not observed, individual domains were correlated with some in-hospital outcomes. Conclusion There was a higher prevalence of smokers among individuals with STEMI. Domains of QOL showed a statistically significant relationship with the occurrence of in-hospital cardiovascular events, with no difference between the types of AMI.

All data used in the work were made available by The Institute for Health Metrics and Evaluation (IHME), accessed through the website http://www.healthdata.org/covid/data-downloads, on August 15, 2020

Objetivo: avaliar a qualidade de vida relacionada à saúde de pacientes antes e depois de sua participação em um programa de perda de peso. Método: estudo observacional e comparativo, cuja amostra foi não probabilística por conveniência, constituída por 35 pacientes atendidos em um serviço de endocrinologia de uma universidade pública de Sergipe. A coleta de dados foi realizada antes e depois da inclusão dos participantes em um programa de redução de peso por meio de um questionário sociodemográfico e o Impact of Weight on Quality of Life-Lite (IWQOL-Lite). Resultados: houve predominância do sexo feminino (91,4%); média de idade 42 anos; cor da pele não branca (71,4%); baixa escolaridade (57,1%) e baixa renda (97,1%). A comorbidade mais frequente foi a hipertensão arterial sistêmica (72,4%). A redução do peso e o IMC apresentaram correlação com os domínios função física, vida sexual, trabalho e dificuldades em locais públicos. Conclusão: Pacientes do programa obtiveram redução de peso; aumento na função física, vida sexual, capacidade de trabalho e redução das dificuldades em locais públicos, alcançando melhoria da qualidade de vida.

A qualitative and quantitative analysis of the Sars-CoV-2 pandemic, verifying evidence of Misthanasia, even in territories with no lack of human and economic resources, due to the prioritizing of economic stabilization and the naturalization of deaths within the national public policies. As an observational territory, the United Kingdom has had its data produced and communicated in an official manner, in relation to the COVID-19 pandemic, analyzed according to analog and comparative criteria. It was possible to follow the pandemic phenomenon’s evolution through time, in virtue of regular collecting and executed under relatively standardized conditions, which allowed us to create an in-panel analytical exposition, having as a comparative model the data collected in Germany, during the same period. The origin of the data sources produced come from the Institute of Health Metrics and Evaluation (IHME); Worldometer Coronavirus. Therefore, it concludes that Misthanasia characterized the course of public policies and the attitudes of the UK’s government in sight of the Sars-CoV-2 contamination, exposing citizens to the risks of a disease that shows no class predilections and disrespects estates, and has a strong impact on those who are vulnerable. The naturalization of death configures itself on the primordial aspect of necropolitics and necropower, placing economy over health in different States, in the pandemic phenomenon of global scale.

To analyze trends, and the main socioeconomic and clinical factors related to treatment abandonment and the cure of leprosy in Sergipe. For the present study, data from all new cases of cure and abandonment of leprosy treatment notified by the health centers of the municipalities to the SINAN (Information System on Notifiable Diseases) in the state of Sergipe, Brazil, from 2007 to 2017, were used. This is an ecological study of cases of cure and abandonment of leprosy treatment, rates were calculated based on the "Guidelines for surveillance, care and elimination of leprosy as a public health problem".using time-series analysis and multivariate logistic regression. Concerning multivariate regression, the young age group presents a higher risk for quitting the treatment (p = 0.429; OR = 2.75). Blacks/browns/indigenous were more likely to abandon treatment (p = 0.482; OR = 1.69), as well as multibacillary individuals (p = 0.541; OR = 2.26). Regarding the cure, the young age group has less chances of cure (OR = 0.34). The same happens for the operational classification; the multibacillary patients have a lower chance of cure (OR = 0.35). Finally, individuals with grade 2 of physical disability are less likely to be cured (OR = 0.54). Health services are noticeably weak, especially when it comes to clinical factors associated with treatment abandonment and a low proportion of cure. Multibacillary (Borderline and Lepromatous) are responsible for the active transmission of leprosy. Analizar las tendencias y los principales factores socioeconómicos y clínicos relacionados con el abandono del tratamiento y la curación de la lepra en Sergipe. Para el presente estudio se utilizaron datos de todos los nuevos casos de curación y abandono del tratamiento de la lepra notificados por los centros de salud de los municipios al SINAN (Sistema de Información de Enfermedades Notificables) del estado de Sergipe, Brasil, de 2007 a 2007. 2017. Se trata de un estudio ecológico de casos de cura y abandono del tratamiento de la lepra, cuyas tasas se calcularon con base en las "Directrices para la vigilancia, atención y eliminación de la lepra como problema de salud pública", utilizando análisis de series de tiempo y regresión logística. multivariante. En relación con la regresión multivariante, el grupo de edad joven tiene mayor riesgo de abandonar el tratamiento (p = 0,429; OR = 2,75). Los negros / pardos / indios tuvieron más probabilidades de abandonar el tratamiento (p = 0,482; OR = 1,69), así como los multibaciliarios (p = 0,541; OR = 2,26). En cuanto a la cura, el grupo de edad joven tiene menos posibilidades de cura (OR = 0,34). Lo mismo ocurre con la clasificación operativa; es menos probable que se curen los multibaciliarios (OR = 0,35). Finalmente, las personas con grado 2 de discapacidad física tienen menos probabilidades de curarse (OR = 0,54). Los servicios de salud son visiblemente frágiles, especialmente cuando se trata de factores clínicos asociados con el abandono del tratamiento y una baja tasa de curación. Los multibacilarios (Borderline y Virchowian) son responsables de la transmisión activa de la lepra. Analisar as tendências e os principais fatores socioeconômicos e clínicos relacionados ao abandono do tratamento e à cura da hanseníase em Sergipe. Para o presente estudo, foram utilizados os dados de todos os casos novos de cura e abandono do tratamento da hanseníase notificados pelos centros de saúde dos municípios ao SINAN (Sistema de Informação de Agravos de Notificação) do estado de Sergipe, Brasil, de 2007 a 2017. . Trata-se de um estudo ecológico de casos de cura e abandono do tratamento da hanseníase, cujas taxas foram calculadas com base nas "Diretrizes para vigilância, atenção e eliminação da hanseníase como problema de saúde pública", utilizando análise de séries temporais e regressão logística multivariada. Em relação à regressão multivariada, a faixa etária jovem apresenta maior risco para abandono do tratamento (p = 0,429; OR = 2,75). Negros / pardos / indígenas apresentaram maior chance de abandonar o tratamento (p = 0,482; OR = 1,69), assim como multibacilares (p = 0,541; OR = 2,26). Em relação à cura, a faixa etária jovem tem menos chances de cura (OR = 0,34). O mesmo acontece para a classificação operacional; os multibacilares têm menor chance de cura (OR = 0,35). Por fim, indivíduos com grau 2 de incapacidade física têm menor probabilidade de cura (OR = 0,54). Os serviços de saúde são visivelmente frágeis, principalmente quando se trata de fatores clínicos associados ao abandono do tratamento e baixa proporção de cura. Os multibacilares (Borderline e virchowianos) são os responsáveis ​​pela transmissão ativa da hanseníase.

The present study aimed to analyze the spatial distribution and its temporal trend, and to identify areas of risk for the occurrence of congenital syphilis in Sergipe, Northeastern Brazil. An ecological study of time series and spatial analysis techniques was performed, with municipalities as units of analysis. Data were obtained from the Notifiable Diseases Information System and included all cases of congenital syphilis reported from 2007 to 2015 in Sergipe. The local empirical Bayesian method used to minimize the rate variance. Spatial autocorrelation was used to analyze spatial patterns. 2,381 new cases of congenital syphilis were recorded in the studied period. A unique trend was found to increase the incidence, ranging from 2.7 (2007) to 11 (2015) per 1,000 live births. The average incidence in the period was 7.63 cases per 1,000 live births. Moran's global index was I = 0.64 (p

This study aimed to analyze the performance of the Schistosomiasis Epidemiological Surveillance System in Sergipe, Brazil. This study used a mixed methodology, with a quantitative approach and the application of semi-structured interviews, directed to professionals of Health Surveillance and Primary Care in seven regional health departments headquarters in Sergipe, as well as information obtained in Sistema de Informação do Programa de Controle da Esquistossomose (SISPCE), Sistema de Informação sobre Mortalidade (SIM) and Sistema de Informação de Agravos de Notificação (SINAN). Interviews were applied from March to October 2018 and secondary data obtained in the information systems corresponded to the period between 2013 and 2018, when structure and process indicators were compared with result indicators. The main critical point was the lack of implementation of the Schistosomiasis Control Program (PCE) in the entire endemic area, lack of interaction between Epidemiological Surveillance and Primary Care, deficiencies in the management and execution of field actions. Failures in the implantation in the PCE, in the structure and process of the Surveillance System, in addition to the need for greater integration between the professionals of the Epidemiological Surveillance and other health sectors, negatively influence the results of the PCE, and may have similar causes and results in the others endemics of the state. Este estudio tuvo como objetivo analizar el desempeño del Sistema de Vigilancia Epidemiológica de la Esquistosomiasis en el estado de Sergipe. Para ello, se utilizó una metodología mixta, con un enfoque cuantitativo, con la aplicación de entrevistas semiestructuradas, dirigidas a profesionales de Vigilancia en Salud y Atención Primaria (AB) en las sedes de los siete departamentos regionales de salud del estado. De esta manera, se obtuvo información a través del Sistema de Información del Programa de Control de Esquistosomiasis (SISPCE), Sistema de Información de Mortalidad (SIM) y Sistema de Información de Enfermedades Notificables (SINAN). Las entrevistas fueron aplicadas entre los meses de marzo a octubre 2018 y los datos secundarios, obtenidos a partir de estos sistemas de información, corresponden al período de 2013 y 2018 cuando la comparación de los indicadores de estructura y de proceso con los indicadores de resultados se llevó a cabo. Se encontró que los principales puntos críticos: la ausencia de actividades PCE en varios municipios de un área endémica; falta de interacción entre Vigilancia Epidemiológica (VE) y Atención Primaria; y las deficiencias en la gestión y ejecución de acciones de campo. Este estudo teve como objetivo analisar o desempenho do Sistema de Vigilância Epidemiológica da Esquistossomose em Sergipe, Brasil. Foi utilizada metodologia mista, com abordagem quantitativa e aplicação de entrevistas semiestruturadas, direcionadas aos profissionais da Vigilância em Saúde e Atenção Básica de sete regionais de saúde sediadas em Sergipe, bem como informações obtidas no Sistema de Informação do Programa de Controle da Esquistossomose (SISPCE), Sistema de Informação sobre Mortalidade (SIM) e Sistema de Informação de Agravos de Notificação (SINAN). As entrevistas foram aplicadas de março a outubro de 2018 e os dados secundários obtidos nos sistemas de informação corresponderam ao período de 2013 a 2018, quando foram comparados indicadores de estrutura e processo com indicadores de resultado. Foi demonstrado como ponto crítico principal, a ausência de implantação do Programa de Controle da Esquistossomose (PCE) na totalidade da área endêmica, falta de interação entre Vigilância Epidemiológica e Atenção Básica, deficiências na gestão e execução de ações de campo. Falhas na implantação no PCE, na estrutura e no processo do Sistema de Vigilância, além da necessidade de uma maior integração entre os profissionais da Vigilância Epidemiológica e demais setores da saúde, influenciam negativamente nos resultados do PCE, podendo ter causas e resultados semelhantes nas demais endemias do estado.

Specimens of Hippocampus patagonicus obtained in the bycatch of trawling in the states of Rio Grande do Sul (RS) and Rio de Janeiro (RJ) were collected in 2012 (n = 199) and 2014 (n = 157), respectively. Mean height of females of reproductive age in RS was 8.89 ± 1.9 cm, with the fecundity of 366 ± 195.8 eggs per clutch, and for males of reproductive age, height was 8.79 ± 1.86 cm and weight 2.3 ± 1.67 g, with 404 ± 99 embryos at each gestation. In RJ, height was 9.69 ± 1.05 cm and weight 2.9 ± 0.9 g, with the fecundity of 277 ± 95.06 eggs per clutch, and for males, height was 10.06 ± 1.02 cm and weight 3.68 ± 1.18 g, with the fecundity of 156.38 ± 66 embryos at each gestation. The equations obtained from the weight (W) to height (H) ratio were: W = 0.002 H 3.182 , R 2 = 0.947 (RS males); W = 0.004 H 2.914 , R 2 = 0.949 (RS females); W = 0.0050 H 2.838 , R 2 = 0.793 (RJ males); W = 0.014 H 2.355 , R 2 = 0.733 (RJ females). RS females produced more eggs (P = 0.023), and males incubated more embryos (P = 0.000) than those of RJ. The mean height of brood pouch formation in males was 4.69 ± 0.48 cm, 95% CI [4.53; 4.86], while the mean height at first sexual maturity was 8.34 cm (95% CI [7.481; 9.046]). Alternative strategies need to be developed for the conservation of H. patagonicus in Brazil.