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321 results on '"K., Umehara"'

2. Development of a low-cost-high-sensitivity Compton camera using CsI (Tl) scintillators (γI)

Author

Shohei Yanagita, Hideaki Katagiri, R. Hanafusa, Ryoji Enomoto, K. Umehara, Tatsuo Yoshida, Tomohisa Uchida, M. Kagaya, K. Satoh, Y. Itoh, Tohoru Takeda, M. Hosokawa, Manobu Tanaka, K. Nakayama, Hiroshi Muraishi, and Takara Watanabe

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, medicine.medical_specialty, Physics::Instrumentation and Detectors, business.industry, Detector, Gamma ray, Scintillator, Particle detector, Optics, Scintillation counter, medicine, Medical physics, Angular resolution, Nuclide, business, Instrumentation
Abstract

We have developed a novel low-cost gamma-ray imaging Compton camera γI that has a high detection efficiency. Our motivation for the development of this detector was to measure the arrival directions of gamma rays produced by radioactive nuclides that were released by the Fukushima Daiichi nuclear power plant accident in 2011. The detector comprises two arrays of inorganic scintillation detectors, which act as a scatterer and an absorber. Each array has eight scintillation detectors, each comprising a large CsI (Tl) scintillator cube of side 3.5 cm, which is inexpensive and has a good energy resolution. Energies deposited by the Compton scattered electrons and subsequent photoelectric absorption, measured by each scintillation counter, are used for image reconstruction. The angular resolution was found to be 3.5° after using an image-sharpening technique. With this angular resolution, we can resolve a 1 m 2 radiation hot spot that is located at a distance of 10 m from the detector with a wide field of view of 1 sr. Moreover, the detection efficiency 0.68 cps/MBq at 1 m for 662 keV (7.6 cps/μSv/h) is sufficient for measuring low-level contamination (i.e., less than 1 μSv/h) corresponding to typical values in large areas of eastern Japan. In addition to the laboratory tests, the imaging capability of our detector was verified in various regions with dose rates less than 1 μSv/h (e.g., Fukushima city).

Published
2015
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3. A retrospective survey of autotransplantation of teeth in dental clinics

Author

K, Yoshino, N, Kariya, D, Namura, I, Noji, K, Mitsuhashi, H, Kimura, A, Fukuda, I, Kikukawa, T, Hayashi, N, Yamazaki, M, Kimura, K, Tsukiyama, K, Yamamoto, A, Fukuyama, D, Hidaka, J, Shinoda, H, Mibu, Y, Shimakura, A, Saito, S, Ikumi, K, Umehara, F, Kamei, H, Fukuda, T, Toake, Y, Takahashi, Y, Miyata, S, Shioji, M, Toyoda, N, Hattori, H, Nishihara, R, Matsushima, M, Nishibori, O, Hokkedo, M, Nojima, T, Kimura, M, Fujiseki, S, Okudaira, K, Tanabe, M, Nakano, K, Ito, M, Kuroda, and T, Matsukubo

Subjects
Adult, Male, Adolescent, Dental Clinics, Oral Surgical Procedures, Middle Aged, Transplantation, Autologous, Young Adult, Treatment Outcome, Humans, Female, Tooth, Aged, Follow-Up Studies, Retrospective Studies
Abstract

The aim of this study was to investigate the usage of tooth autotransplantation in dental clinics which offer the treatment and evaluate its practicality. Participating dentists were requested to provide information on transplantations they had undertaken from 1 January 1990 to 31 December 2010. A total of 614 teeth from 552 patients (37 dentists) ranging in age from 17 to 79 (mean age: 44·1) were examined. Cumulative survival rate and mean survival time were calculated using the Kaplan-Meier method, and log rank test was used for analysis of factors. The mean number of autotransplantation patients per clinic per year was 1·4. Upper third molars constituted 36·8% of donor teeth, while 37·1% were lower third molars. The lower first molar region was the most common recipient site at 32·6%, followed by the lower second molar region (28·0%). Prosthodontic treatment of transplanted teeth involved coverage with a single crown (72·5%) and abutment of bridge (18·9%). A total of 102 transplanted teeth were lost owing to complications such as attachment loss (54·9%) and root resorption (25·7%). The cumulative survival rate in cases where donor teeth had complete root formation was 90·1% at 5 years, 70·5% at 10 years and 55·6% at 15 years. The mean survival time was 165·6 months. Older age was a significant risk factor (P0·05) for survival. In cases where suitable donor teeth are available, autotransplantation of teeth may be a plausible treatment option for dealing with missing teeth in dental clinics.

Published
2012

4. Introducing the CTA concept

Author

A. Mathieu, R. G. Wagner, K. Panagiotidis, S Rosier Lees, Julien Rousselle, M. Gómez Berisso, Michela Uslenghi, Stephen Maxfield, R. C. Shellard, Ivica Puljak, T. Le Flour, Thomas Schanz, Tobias C. Walther, Juanan Aguilar, Pierre Colin, M. Chikawa, N. Fouque, Mosè Mariotti, G. Fontaine, Merja Tornikoski, V. Diez-Blanco, Enrico Giro, A. Krepps, G. Koss, J. M. Martin, Sergio Billotta, E. de Oña Wilhelmi, Keitaro Takahashi, S. Buson, P. Brook, S. Steiner, M. Dyrda, Joseph Silk, Sera Markoff, P. Lubinski, U. Schwanke, Sauvik Bhattacharyya, J. Ripken, T. Haubold, C. Zurbach, H. Wetteskind, R. Hermel, J. Darling, J. Nicolau-Kukliński, Konstancja Satalecka, M. Videla, Stefan Funk, P. Conconi, S. Bajtlik, Lukasz Stawarz, J. M. Paredes, K. Reitberger, Stefan Wagner, Teresa Mineo, David Kieda, G. Pareschi, Shigeto Kabuki, Makoto Sawada, Antonio Stamerra, Rodolfo Canestrari, N. Baby, G. Crimi, P. Kostka, J. Grube, R. Zanin, I. K. Kominis, L. Mc Comb, R. Sternberger, M. Fesquet, M. Tokarz, David Fink, Daniela Dorner, N. Hamer Heras, A. Moralejo Olaizola, M. de Naurois, Diego F. Torres, Claes Fransson, K. Nishijima, Yutaka Fujita, L. Fresnillo, B. García, R. Kossakowski, A. Masserot, H. von Gunten, Alkiviadis F. Bais, Ciro Bigongiari, A. Saggion, G. Papyan, I. Mrusek, K. Farakos, J. Michałowski, A. Franckowiak, Fernando Martinez, M. Doert, R. Wawrzaszek, Michele Doro, L. Sapozhnikov, Claudia Lavalley, D. Thuermann, A.A. Zdziarski, Cristina Knapic, Karen Byrum, N. Neyroud, Petr Schovanek, W. Domainko, D. Kastana, E. Birsin, Adrian Biland, F. Sánchez, Alexandre Marcowith, M. Errando, R. L. C. Starling, J. Schultze, A. Weinstein, B. B. Singh, Yassir Moudden, Jelena Aleksić, C. L. Naumann, V. Waegebaert, M. Shayduk, U. F. Katz, Gianpiero Tagliaferri, M. Schroedter, A. Vollhardt, O. Reimann, Hideyuki Ohoka, Vincenzo Testa, C. Jablonski, Tsuguya Naito, J. Schäfer, Stavros Maltezos, A. Wierzcholska, P. Wawer, L. Nellen, F. Mirabel, Tatsuo Yoshida, P. H. Carton, Nina Nowak, L. Platos, Riccardo Rando, P. P. Krueger, R. Wischnewski, W. Romaszkan, E. Fede, Martino Marisaldi, Markus Gaug, Richard Willingale, J. H. Buckley, U. De AlmeidaBarres, J. Knapp, Saverio Lombardi, D. della Volpe, A. Herrero, A. Bottani, E. Delagnes, Martin J. Hardcastle, C. Morello, Anna Lipniacka, T. Greenshaw, M. Renaud, Giancarlo Cusumano, Jonathan Biteau, M. Sowiński, J. R. T. de Mello Neto, T. B. Humensky, Michael G. Richer, G. Parks, G. Grasseau, H. Baba, Gino Tosti, Damir Lelas, H. Krawzcynski, David Paneque, M. Barcelo, R. Dickherber, P. Ferrando, Shinji Hara, D. Florin, Hideaki Katagiri, T. Shibata, Fuyuki Tokanai, N. A. McCubbin, J. Gomez-Ortega, D. Nakajima, A. Liolios, P. Laporte, Orjan Dale, A. Sillanpää, Dainis Dravins, Timothée Grégoire, Nu. Komin, A. Mihailidis, L. Sidoli, Shiu-Hang Lee, A. W. Chen, J. M. Illa, A. Kuznetsov, P. Munar-Adrover, D. Dominis Prester, Marcos Daniel Actis, Abraham D. Falcone, L. Journet, D. Hadasch, N. Galante, A. Murphy, C. J. Todero Peixoto, S. Wiesand, A. Aravantinos, A. C. Rovero, J. L. Dournaux, P. Romano, M. Hrabovsky, R. de los Reyes Lopez, M. Ostrowski, J. Pallota, Geza Gyuk, Petar Temnikov, R. Dubois, Jan Ebr, R. Koul, David J. Smith, S. Schwarzburg, P. Manigot, Chad Finley, Tarek M. Hassan, Giuseppe Sottile, Evgeni Ovcharov, P. J. Rajda, F. Krennrich, Peter L. Moore, W. B. Focke, W. Bednarek, Elena Amato, Kazunori Kohri, J. Gamez-Garcia, I. Oya, A. Shibuya, German Hermann, William H. Lee, Dorota Sobczyńska, X. Zhou, C. Balkowski, G. Vallejo, M. Hayashida, M. Bitossi, Loukas Vlahos, H. Lockart, N. Geffroy, L. Tibaldo, Marek Jamrozy, Luke O'c. Drury, Pratik Majumdar, P. Sutcliffe, S. Schlenstedt, M. Palatka, Christophe Champion, H. Ueno, M. Rupiński, P. Giommi, J. Schwarz, G. Pühlhofer, Takashi Saito, W. van Driel, C. van Eldik, Q. Xiong, Yasuo Fukui, A. Donat, A. Ibarra, R. S. Warwick, Michiko Ohishi, A. W. Smith, J.-P. Lenain, Aion Viana, Terry Ashton, Guillaume Dubus, Jacek Niemiec, K. Kodani, Luis Ángel Tejedor, A. Wörnlein, Takanori Yoshikoshi, Masahiro Teshima, W. Gäbele, Ll. Font, Olaf Reimer, J. F. Valdés-Galicia, Lucy Fortson, J. P. Osborne, Mattia Fornasa, Keith Bechtol, Masayuki Tanaka, Shigehiro Nagataki, M. Rataj, M. Ribordy, Emmanuel Moulin, I. de la Calle, K. Winiarski, C. Jeanney, I. Mognet, I. Vegas, C. Juffroy, Yutaka Ohira, A. Jacholkowska, Matthew Wood, A. E. Suárez, J. Bähr, K. M. Schure, J. Maya, M. Dafonseca, J. Tasan, R. Sugawara, M. Bourgeat, A. Mancilla, D. Pelat, Olga Botner, D. Nedbal, G. Depaola, Robert Wagner, T. Okuda, H. Arnaldi, Josep Martí, P. Corona, T. Bonev, D. Yelos, J. Sieiro, V. Scalzotto, Jacco Vink, D. Languignon, Marco Ajello, J. Vandenbrouke, Philipp Mertsch, M. Mordalska, P. Wegner, P. Ziółkowski, P. T. O'Brien, A. Nozato, Robert D. Preece, B. Huber, Matteo Balbo, J.R. Bogart, R. Kankanyan, K. Mori, T. Jogler, Seth Digel, Claudio Vuerli, Hiromitsu Takahashi, Thomas Lohse, K. Saito, A. W. Borgland, Elisa Prandini, Helene Sol, Ryan Heller, M. Bogdan, D. Dumas, M. Stodulski, Y. Awane, Piercarlo Bonifacio, Pedro L. Luque-Escamilla, Judith H. Croston, Fabio Pizzolato, P. M. Chadwick, M. K. Daniel, Riccardo Paoletti, Reiko Orito, Katsuaki Asano, R. Frei, G. Disset, Valerie Connaughton, Juhani Huovelin, Hiroyasu Tajima, S. Vercellone, F. Feinstein, G. Decerprit, Riccardo Smareglia, S. Spyrou, Gustavo E. Romero, J. Shi, J. Carr, N. Girard, Dirk L. Hoffmann, Andreas Zech, Markus Boettcher, Osvaldo Catalano, Akira Okumura, M. Dohmke, C. Föhr, Sabrina Casanova, R. A. Cameron, Jan Conrad, K. Umehara, K. K. Yadav, A. Paizis, John L. Quinn, L. Pogosyan, C. Farnier, William J. Potter, Domenico Impiombato, Tadashi Kifune, Jonathan Granot, Gernot Maier, M. Cieślar, S. Palanque, G.W. Fraser, J. Prast, R. Bose, Heidi Sandaker, G. Lamanna, Dusan Mandat, J.F. Glicenstein, J. Harris, D. Naumann, J. Ziolkowski, Michał Szanecki, C. Delgado, J. Kocot, W. Lustermann, Sabine Elles, J. Schmoll, L. Gérard, M. López, Norita Kawanaka, V. Gika, B. Lieunard, A. Pichel, Martin Pohl, Mariusz Sterzel, S. Vincent, Paolo De Coppi, J. Lande, O. Blanch Bigas, Gianluca Giavitto, Yusuke Konno, Julian Sitarek, M. Panter, P.-O. Petrucci, F. Henault, M. Prouza, Philip Kaaret, Josep Colomé, Luciano Nicastro, German Martinez, L. Gebremedhin, J. M. Yebras, Apostolos Mastichiadis, A. S. Madhavan, Thomas J. Maccarone, K. Berger, R. Buehler, P. Jean, N. Sartore, F. Toussenel, Aris Karastergiou, W. Kluźniak, A. Djannati-Ataï, S. J. Fegan, Louis Antonelli, A. González Muñoz, J. Berdugo, S. S. Upadhya, M. Sidz, F. Mottez, Patrick Vogler, F. Di Pierro, Wystan Benbow, B. Sacco, L. Chiappetti, J. Dumm, R. Firpo Curcoll, David Gascon, V. Boccone, J. Krause, J. P. Avernet, B. Peyaud, B. De Lotto, Ana Babić, T. O. B. Schmidt, I. M. McHardy, T. Schweizer, S. P. Wakely, Daniel Gall, Frank M. Rieger, E. Sant'Ambrogio, M. Kagaya, P. Vincent, R. C. Rannot, Sandro Mereghetti, A. De Angelis, M. Scarcioffolo, R. White, G. H. Sembroski, Takeshi Nakamori, C. Medina, M. A. De Oliveira Leigui, Subir Sarkar, A. Marszałek, Reshmi Mukherjee, K. Nakayama, A. Fiasson, S. Giarrusso, T. Bernardino, J. P. Finley, D. Neise, L. O. Takalo, F. Grañena, Nikola Godinovic, H. Sasaki, P. Zychowski, Francesco Dazzi, B. Courty, A. Basili, Vitaly Neustroev, B. Khélifi, T. Glanzman, M. Trifoglio, Regis Terrier, R. A. Ong, E. M. Santos, M. Minuti, Thomas Bretz, R. Moderski, J. Kushida, S. Royer, Emilio Molinari, Etienne Lyard, J. Houles, Juan Abel Barrio, T. Lerch, S. Rivoire, T. Kishimoto, M. Cailles, M. Casiraghi, Nikolaos Stergioulas, J. Gaweda, S. Koyama, Ingomar Allekotte, E. Ismailova, Elina Giannakaki, S. Schwemmer, Ryo Yamazaki, G. Fasola, Christoph Deil, Jose Luis Contreras, T. Bird, Miguel A. Sánchez-Conde, J. Dick, E. Edy, D. Parsons, R. Pyzioł, R. Mirzoyan, Manjuli R. Sharma, J. Borkowski, Jonathan S. Lapington, Cameron B Rulten, Rino Bandiera, Volker Beckmann, Jun Kakuwa, Dimitris Balis, Kenji Toma, Anna Barnacka, Andrea Santangelo, L. Padilla, Peter Eger, G. Decock, Karol Seweryn, N. Sakaki, Darko Veberič, Andrea Bulgarelli, B. Rudak, M. Pérez, H. Koppel, Felix Spanier, M. I. Martínez, D. Horville, Marco Molinaro, R. Walter, P. Ramon, S. Brau-Nogue, J. Camprecios, K. Kärcher, John H. Seiradakis, S. Criswell, D. J. Leopold, V. J. Guarino, R. Gredig, S. Vorobiov, Viktor Gruev, Gareth Hughes, Daniele Spiga, Quirin Weitzel, N. Håkansson, Susumu Inoue, U. Straumann, Juan Cortina, B. Behera, Jürgen Knödlseder, Daniel Nieto, Tomasz Szepieniec, H. Prokoph, Jerzy Grygorczuk, G. De La Vega, Jim Hinton, E. Chabanne, M. Mahabir, R. Krobot, M. Capalbi, Miroslav Pech, C. Díaz, J. Ludwin, F. Gianotti, Garret Cotter, Claudio Melioli, Hiroaki Yamamoto, C. Veyssiere, Kunihito Ioka, S. Sun, J. M. Parraud, L. Rob, Felix Aharonian, G. Maneva, D. Melkumyan, T. Schwab, J. Kasperek, J. M. Huet, E. Lorenz, S. Tanaka, Y. A. Gallant, S. Couturier, B.W. Favill, J. Boix Gargallo, Andrea Tiengo, Leszek Bogacz, Andreu Sanuy, Christian Fruck, J. Sykes, C. Martens, A. Yoshida, Marek Sikora, E. Racero, G. Rouaix, N. Bhat, A. Salini, A. S. Barber, Mauro Ghigo, Jan Ridky, K. Kosack, Konrad Bernlöhr, C. Tenzer, Alice Allafort, M. Torres, Catherine Boisson, Grzegorz Kowal, M. Karczewski, G. Agnetta, Victor Stamatescu, Anthony H. Gonzalez, S. Rousselle, Giovanni Bonanno, A. Zajczyk, A. Gadola, P. Martin, V. Zitelli, I. Manthos, N. Maragos, A. Dettlaff, F. Profeti, S. Colonges, S. Gunji, S. Cazaux, S. Colafrancesco, M. Paz Arribas, Rika Hagiwara, Darell Engelhaupt, Nestor Mirabal, Johann Cohen-Tanugi, S. Grunewald, Abby M. Green, I. D. Davids, D. Nosek, T. Yamamoto, Gagik Tovmassian, R. Sakonaka, Miguel Alcubierre, C. Baixeras, T. L. Usher, Kazufumi Torii, H. Lüdecke, L. Wiśniewski, B. Kellner-Leidel, P. Demange, F. Gonzalez, B. Moal, V. De Caprio, V. Golev, K. Katarzyński, V. Bugaev, A. Reimer, J. Koziol, G. Pojmanski, Alessandro Carosi, J. Bolmont, A. Nikolaidis, R. J. García López, V. A. Kudryavtsev, C. Stegmann, J.-P. Ernenwein, M. Fiorini, Ivone F. M. Albuquerque, Marco Tavani, P. Korohoda, A. Giuliani, E. Carmona, C. Bauer, Kostas D. Kokkotas, O. Tibolla, G. Deleglise, Pierre Brun, Dinko Dimitrov, I. Jung, R. Steenkamp, Marc Ribó, Kathrin Egberts, P. Reardon, Adriano Ghedina, Stefan Rosén, N. Hidaka, Trygve Buanes, A. Segreto, H. Huan, Juri Poutanen, Ruben Lopez-Coto, S. Cavazzani, Massimiliano Belluso, A. Kretzschmann, F. De Frondat, A. Riviere, J. F. Olive, Tsunefumi Mizuno, Serena Mattiazzo, M. González, D. Fantinel, Matteo Cerruti, S. Vergani, Sabrina Einecke, N. La Palombara, Reinhard Schlickeiser, P. Antoranz, Pol Bordas, D. Paillot, V. de Souza, Yasushi Fukazawa, Phil Evans, Werner Hofmann, Hugh Dickinson, F. Roy, Yvonne Becherini, E. O. Angüner, D. Corti, T. C. Arlen, Francesco Russo, V. R. Chitnis, D. Ross, R. Gabriele, Massimo Persic, E. Fokitis, A. Bonardi, D. Garrido, A. Niedźwiecki, L. Cossio, Hidetoshi Kubo, Y. de Oliveira, F. Mattana, Anna Szostek, M. Compin, S. Blake, F. Lucarelli, Petter Hofverberg, Felix Ryde, M. Gougerot, C. Boutonnet, Dimitrios Emmanoulopoulos, A. Mangano, P. Vallania, Jose Miguel Miranda, A. Manalaysay, M. Raue, A. Bouvier, Shohei Yanagita, Nektarios Vlahakis, Joni Tammi, M. Naumann-Godo, Kohta Murase, E. Fillin-Martino, Jiri Chudoba, K. Hatanaka, A. Lopatin, N. Otte, G. Rojas, Tomonori Totani, K. S. Gothe, J. P. Vialle, D. Kolitzus, K. Warda, Hironori Matsumoto, J. Rico, P. Ringegni, James Chiang, R. McKay, A. Bobkov, Aya Bamba, H. Takami, B. Giebels, O. Grimm, S. Basso, F. Dubois, Victor Zabalza, A. Förster, Pasquale Blasi, Alexandros Papayannis, A. G. Akhperjanian, Eckhard Kendziorra, James A. Anderson, Giuseppe Malaguti, R. Welsing, S. Pita, A. Ozieblo, Heide Costantini, D. Tezier, J.-H. Köhne, M. Tluczykont, Ll. Garrido, Alexander Varón Sandoval, Matthew R. Orr, Dominique Durand, F. Chollet, O. Luz, E. O. Saemann, Jun Kataoka, M. Proyetti, C. Barbier, Jürgen Barnstedt, L. Bouchet, Hiroshi Muraishi, Anton N. Baushev, L. A. Otero, Denis Bastieri, S. Incorvaia, Tihomir Surić, V. La Parola, Nathan Smith, Karl-Heinz Sulanke, F. Bernard, Luca Stringhetti, S. Paiano, S. Federici, Hector Flores, Karl Mannheim, Michael S. Briggs, Giovanna Pedaletti, E. M. de Gouveia Dal Pino, J. D. Smith, G. La Rosa, Alicia López-Oramas, M. Janiak, Gary Drake, G. Talbot, Petr Travnicek, Elisabetta Bissaldi, Mario Meucci, R. Northrop, V. Scapin, Vito Conforti, J. D. Ponz, T. Aghajani, J. J. Jimenez, A. D. Supanitsky, Hernán Asorey, M. Werner, Brian Reville, A. Haupt, C. Skole, Gilles Henri, Daniele Gardiol, V. Vassiliev, R. Platzer, Y. Saito, A. La Barbera, Allan Hallgren, C. Eleftheriadis, S. Cantu, G. Maurin, K. Lacombe, A. Le Padellec, F. Stinzing, T. Hayakawa, A. Cillis, M. Suchenek, I. Monteiro, V. Sahakian, A. Di Paola, Grzegorz Madejski, A. De Luca, Andreas Quirrenbach, P. A. Caraveo, N. A. Webb, Michael Zacharias, J. Vanderwalt, Dario Hrupec, K. Ziȩtara, T. Armstrong, A. Lorca, T. Krähenbühl, A. Etchegoyen, Stefano Covino, C. Kalkuhl, K. Kitamoto, Tomasz Bulik, R. Rohlfs, D. Allan, A. Zhao, Luisa Arrabito, B. S. Acharya, T. Johnson, C. Schultz, G. Vasileiadis, Eleen Shum, Daniel Ferenc, Paola Grandi, Maria Concetta Maccarone, E. Strazzeri, H. Kelly, E. J. Quel, H. Vankov, Ruben Alfaro, I. Telezhinsky, J. Becker Tjus, C. Dufour, F. Köck, Ilana M. Braun, Jamie Holder, Ryoji Enomoto, Luigi Lessio, Michael Punch, Stefano Gabici, I. Puerto-Gimenez, S. Karkar, P. Nayman, M. Grudzińska, E. Aliu, Yoshiyuki Inoue, Elina Lindfors, J. Becerra, Daniel Mazin, Yukikatsu Terada, André Schulz, Teresa Montaruli, G. Bonnoli, S. Renner, Dieter Horns, J. Dyks, V. Pelassa, Mark I. Wilkinson, Ricardo Graciani, I. Troyano, P. Ristori, Thomas Kihm, P. Micolon, S. J. Nolan, Torsten Bringmann, David A. Williams, Joachim Hahn, L. Brunetti, U. Roeser, Wolfgang Rhode, Kanaris Tsinganos, Stefan Ohm, J. L. Panazol, G. Busetto, B. S., Acharya, M., Acti, T., Aghajani, G., Agnetta, J., Aguilar, F., Aharonian, M., Ajello, A., Akhperjanian, M., Alcubierre, J., Aleksic, R., Alfaro, E., Aliu, A. J., Allafort, D., Allan, I., Allekotte, E., Amato, J., Anderson, E. O., Anguener, L. A., Antonelli, P., Antoranz, A., Aravantino, T., Arlen, T., Armstrong, H., Arnaldi, L., Arrabito, K., Asano, T., Ashton, H. G., Asorey, Y., Awane, H., Baba, A., Babic, N., Baby, J., Baehr, A., Bai, C., Baixera, S., Bajtlik, M., Balbo, D., Bali, C., Balkowski, A., Bamba, R., Bandiera, A., Barber, C., Barbier, M., Barcelo, A., Barnacka, J., Barnstedt, U. B., De, J. A., Barrio, A., Basili, S., Basso, D., Bastieri, C., Bauer, A., Baushev, J., Becerra, Y., Becherini, K. C., Bechtol, J. B., Tju, V., Beckmann, W., Bednarek, B., Behera, M., Belluso, W., Benbow, J., Berdugo, K., Berger, F., Bernard, T., Bernardino, K., Bernloehr, N., Bhat, S., Bhattacharyya, C., Bigongiari, A., Biland, S., Billotta, T., Bird, E., Birsin, Bissaldi, Elisabetta, J., Biteau, M., Bitossi, S., Blake, O. B., Biga, P., Blasi, A., Bobkov, V., Boccone, M., Boettcher, L., Bogacz, J., Bogart, M., Bogdan, C., Boisson, J. B., Gargallo, J., Bolmont, G., Bonanno, A., Bonardi, T., Bonev, P., Bonifacio, G., Bonnoli, P., Borda, A., Borgland, J., Borkowski, R., Bose, O., Botner, A., Bottani, L., Bouchet, M., Bourgeat, C., Boutonnet, A., Bouvier, S., Brau Nogue, I., Braun, T., Bretz, M., Brigg, T., Bringmann, P., Brook, P., Brun, L., Brunetti, T., Buane, J., Buckley, R., Buehler, V., Bugaev, A., Bulgarelli, T., Bulik, G., Busetto, S., Buson, K., Byrum, M., Caille, R., Cameron, J., Camprecio, R., Canestrari, S., Cantu, M., Capalbi, P., Caraveo, E., Carmona, A., Carosi, J., Carr, P. . ., H., S., Casanova, M., Casiraghi, O., Catalano, S., Cavazzani, S., Cazaux, M., Cerruti, E., Chabanne, P., Chadwick, C., Champion, A., Chen, J., Chiang, L., Chiappetti, M., Chikawa, V. R., Chitni, F., Chollet, J., Chudoba, M., Cieslar, A., Cilli, J., Cohen Tanugi, S., Colafrancesco, P., Colin, J., Calome, S., Colonge, M., Compin, P., Conconi, V., Conforti, V., Connaughton, J., Conrad, J. 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M., Yebra, D., Yelo, A., Yoshida, T., Yoshida, T., Yoshikoshi, V., Zabalza, M., Zacharia, A., Zajczyk, R., Zanin, A., Zdziarski, A., Zech, A., Zhao, X., Zhou, K., Zietara, J., Ziolkowski, P., Ziolkowski, V., Zitelli, C., Zurbach, P., Zychowski, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), APC - Astrophysique des Hautes Energies (APC - AHE), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CTA, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Laboratoire d'Annecy de Physique des Particules (LAPP), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), and High Energy Astrophys. & Astropart. Phys (API, FNWI)

Subjects
Next generation Cherenkov telescopes, Ciencias Físicas, 01 natural sciences, 7. Clean energy, TeV GAMMA-RAY ASTRONOMY, Observatory, Air showers, HESS, Cherenkov Telescopes, 010303 astronomy & astrophysics, MISSION, SUPERNOVA REMNANT W44, TELESCOPE, ASTRONOMY, EMISSION, Physics, ta213, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Settore FIS/01 - Fisica Sperimentale, Astrophysics::Instrumentation and Methods for Astrophysics, TeV gamma-ray astronomy, ddc:540, CIENCIAS NATURALES Y EXACTAS, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Air shower, AIR SHOWERS, Astrophysics::High Energy Astrophysical Phenomena, 0103 physical sciences, Preparatory phase, ta115, TeV gamma-ray astronomy Air showers Cherenkov Telescopes, 010308 nuclear & particles physics, business.industry, CHERENKOV TELESCOPES, Física, Astronomy, Institut für Physik und Astronomie, Astronomy and Astrophysics, ASTROFÍSICA, Cherenkov Telescope Array, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astronomía, Design study, Telecommunications, business
Abstract

The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project., La lista completa de autores puede consultarse en el documento o en la página web de la revista., Facultad de Ingeniería

Published
2013
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5. The Large Size Telescope of the Cherenkov Telescope Array

Author

N. Geffroy, Victor Stamatescu, Manabu Tanaka, T. Shibata, Pratik Majumdar, Luis Ángel Tejedor, S. Podkladkin, Yutaka Ohira, Yoshiyuki Inoue, D. Paneque, Akira Okumura, Abelardo Moralejo, David Gascon, Daniel Mazin, Yukikatsu Terada, Y. Awane, Takashi Saito, M. Kagaya, S. Rosier-Lees, Hideaki Katagiri, T. Le Flour, R. Colin, A. Fiasson, H. Tajima, David Fink, F. Grañena, Juan Abel Barrio, S. Shu, Andreu Sanuy, J. M. Paredes, Nicola Giglietto, Reiko Orito, Masatoshi Ohishi, R. Sakonaka, Ricardo Garcia, Tokonatsu Yamamoto, Kunihito Ioka, S. Gunji, Marc Ribó, G. Pauletta, M. Chikawa, Tatsuo Yoshida, T. Schweizer, Hajime Takami, C. Jablonski, Hidetoshi Kubo, Robert Wagner, D. Nakajima, R. Paoletti, Shigehiro Nagataki, U. Barres de Almeida, K. Saito, Francesco Giordano, H. Baba, Aya Bamba, J. Prast, M. Barcelo, Koji Noda, Y. Saito, Tomonori Totani, K. Nishijima, K. Kodani, Takanori Yoshikoshi, Masahiro Teshima, E. Chabanne, J. Boix, M. López-Moya, K. Umehara, N. Fouque, Kouichi Hirotani, Takeshi Nakamori, Kazunori Kohri, J. L. Panazol, N. Hamer, Jose Miguel Miranda, Yusuke Konno, R. Rebolo Lopez, A. De Angelis, O. Reimann, Hideyuki Ohoka, A. Nozato, Y. Hanabata, A. Gadola, C. Delgado, R. Mirzoyan, N. Sakaki, G. Martinez, H. Ueno, E. Carmona, H. Sasaki, Ryo Yamazaki, S. Schultz, Francesco Dazzi, A. Manalaysay, Kohta Murase, K. Hatanaka, Javier Sieiro, S. Koyama, Giovanni Lamanna, G. Deleglise, O. Blanch Bigas, Mosè Mariotti, Makoto Sawada, Lluis Freixas, V. Scalzotto, J. Kushida, Jose Luis Contreras, Juan Cortina, C. Díaz, I. Monteiro, A. Yoshida, Rika Hagiwara, E. Lorenz, S. Tanaka, G. Ambrosi, Miriam Lucio Martinez, R. Rando, S. Steiner, Tarek M. Hassan, H. Wetteskind, R. Sugawara, A. Vollhardt, T. Kishimoto, Susumu Inoue, U. Straumann, Christian Fruck, and L. Brunetti

Subjects
media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, law.invention, Telescope, law, Imaging Atmospheric Cherenkov Telescope, CTA, gamma-rays, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering, 010303 astronomy & astrophysics, Cherenkov radiation, media_common, Astroparticle physics, Physics, 010308 nuclear & particles physics, Applied Mathematics, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Computer Science Applications1707 Computer Vision and Pattern Recognition, Threshold energy, Cherenkov Telescope Array, Condensed Matter Physics, Sky, Electrónica, Física nuclear, Electricidad, Gamma-ray burst, Electronic, Optical and Magnetic Materials
Abstract

The Cherenkov Telescope Array (CTA) project aims to implement the world’s largest next generation of Very High Energy gamma-ray Imaging Atmospheric Cherenkov Telescopes devoted to the observation from a few tens of GeV to more than 100 TeV. To view the whole sky, two CTA sites are foreseen, one for each hemisphere. The sensitivity at the lowest energy range will be dominated by four Large Size Telescopes, LSTs, located at the center of each array and designed to achieve observations of high red-shift objects with the threshold energy of 20 GeV. The LST is optimized also for transient low energy sources, such as Gamma Ray Bursts (GRB), which require fast repositioning of the telescope. The overall design and the development status of the first LST telescope will be discussed.

Published
2014

6. Development of the camera for the large size telescopes of the Cherenkov Telescope array

Author

Andreu Sanuy, T. Haubold, T. Le Flour, N. Geffroy, Victor Stamatescu, Manabu Tanaka, M. L. Knoetig, H. Baba, Takanori Yoshikoshi, Masahiro Teshima, R. Hermel, Akira Okumura, D. Nakajima, Pratik Majumdar, Luis Ángel Tejedor, J. Hose, David Gascon, T. Toyama, Riccardo Rando, Y. Ohira, M. Kagaya, David Paneque, M. Barcelo, Y. Awane, Y. Tsubone, T. Schweizer, S. Masuda, Tatsuo Yoshida, D. Hugh, O. Blanch Bigas, H. Tajima, Ryo Yamazaki, Koji Noda, Yoshiyuki Inoue, Tokonatsu Yamamoto, J. Kushida, Daniel Mazin, Aya Bamba, Yukikatsu Terada, Robert Wagner, Kouichi Hirotani, K. Umehara, Giovanni Lamanna, Jose Luis Contreras, David Fink, Yusuke Konno, U. Menzel, Miriam Lucio Martinez, Takeshi Nakamori, A. Vollhardt, C. Jablonski, G. Deleglise, Francesco Dazzi, Juan Cortina, O. Reimann, Hideyuki Ohoka, Tarek M. Hassan, S. Steiner, J. L. Panazol, J. M. Paredes, K. Kohri, F. Grañena, Juan Abel Barrio, Ricardo Garcia, K. Kodani, K. Nishijima, S. Koyama, Shigehiro Nagataki, R. Sugawara, Francesco Giordano, M. Hayashida, A. Yoshida, Lluis Freixas, H. Wetteskind, M. Ogino, Kunihito Ioka, H. Ueno, D. Herranz, A. Nozato, Mosè Mariotti, A. Deangelis, Rika Hagiwara, G. Ambrosi, G. Pauletta, C. Díaz, I. Monteiro, J. Prast, E. Lorenz, S. Tanaka, Makoto Sawada, S. Tsujimoto, T. Shibata, C. Delgado, R. Sakonaka, Marc Ribó, J. Boix, S. Rosier-Lees, Hidetoshi Kubo, N. Cho, A. Fiasson, S. Ono, E. Chabanne, Abelardo Moralejo, Hideaki Katagiri, Y. Hanabata, Jun Kataoka, S. Podkladkin, N. Fouque, M. Takahashi, H. Takami, Shuichi Gunji, Y. Umetsu, Y. Tomono, Riccardo Paoletti, V. Scalzotto, K. Saito, Y. Inome, Marcos López-Moya, T. Nagayoshi, Jose Miguel Miranda, Javier Sieiro, N. Sakaki, Michiyuki Chikawa, T. Kishimoto, Susumu Inoue, U. Straumann, Takashi Saito, Y. Saito, Reiko Orito, U. Barres de Almeida, S. Shu, Nicola Giglietto, Christian Fruck, L. Brunetti, Pierre Colin, Y. Tsuchiya, Masatoshi Ohishi, Tomonori Totani, R. Rebolo Lopez, S. Schultz, Shunsuke Matsuoka, A. Manalaysay, Kohta Murase, K. Hatanaka, Hanna Kellermann, N. Hamer, German Martinez, A. Gadola, T. Kojima, R. Mirzoyan, F. Dubois, and E. Carmona

Subjects
Photon, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, law.invention, Optics, law, Electronic, Optical and Magnetic Materials, Electronics, Electrical and Electronic Engineering, Physics, CTA, business.industry, Applied Mathematics, Gamma-rays, Imaging Atmospheric Cherenkov Telescope, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Cherenkov Telescope Array, Cardinal point, Development (differential geometry), Electrónica, Física nuclear, Electricidad, business, Large size
Abstract

The Large Size Telescopes, LSTs, located at the center of the Cherenkov Telescope Array, CTA, will be sensitive for low energy gamma-rays. The camera on the LST focal plane is optimized to detect low energy events based on a high photon detection efficiency and high speed electronics. Also the trigger system is designed to detect low energy showers as much as possible. In addition, the camera is required to work stably without maintenance in a few tens of years. In this contribution we present the design of the camera for the first LST and the status of its development and production.

Published
2014

7. Effect of iodine intercalation on structural and physical properties of misfit cobaltates

Author

Kazuyoshi Yoshimura, Ken Hirota, Y. Goto, K. Umehara, and Masaki Kato

Subjects
Crystallography, Materials science, chemistry, Intercalation (chemistry), chemistry.chemical_element, Partial pressure, Condensed Matter Physics, Iodine, Electronic, Optical and Magnetic Materials
Abstract

We have studied the synthesis and physical properties of misfit cobaltates compounds intercalated by the iodine. The iodine atoms was successfully intercalated into the misfit cobaltates by the heat treatment at a constant iodine partial pressure. In the case of Bi(Pb)–Sr–Co–O system, I α Bi 2 - x Pb x Sr 2 Co 2 O y , it was found that the c -axis drastically increased by the intercalation. The iodine content α was determined to be 0.97 for Pb content x = 0 , and 0.81–0.85 for x > 0.4 . From magnetic and electric measurements for these compounds, it was suggested that the intra-layer couplings between CoO 2 layers are probably reduced by the iodine intercalation.

Published
2007
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8. Metabolism of 1-(3,4-dichlorobenzyl)-5- octylbiguanide in the dog

Author

M Odomi, S Morita, K Umehara, S. Kudo, M Uchida, and Gohachiro Miyamoto

Subjects
Male, Radioisotope Dilution Technique, medicine.drug_class, Health, Toxicology and Mutagenesis, Metabolite, Biguanides, Urine, Spectrometry, Mass, Fast Atom Bombardment, Pharmacology, Biology, Hydroxylation, Toxicology, Biochemistry, Feces, Subcutaneous injection, chemistry.chemical_compound, Dogs, Pharmacokinetics, Antiseptic, medicine, Animals, Carbon Radioisotopes, Biotransformation, Chromatography, High Pressure Liquid, Antibacterial agent, Hexanoic acid, Molecular Structure, Biguanide, General Medicine, chemistry, Anti-Infective Agents, Local
Abstract

1. The biotransformation of 1-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045), a new potent biguanide antiseptic, was investigated in male beagle dogs. Urinary and faecal excretion of unchanged compound and metabolites were studied following a single subcutaneous injection of 14C-labeled compound at a dose of 1 mg/kg. 2. Four urinary metabolites were structually identified using synthetic standards and/or spectral data as 3,4-dichlorobenzoic acid, 6-[5-(3,4-dichlorobenzyl)-1-biguanidino] hexanoic acid (DM-210), 4-[5-(3,4-dichlorobenzl)-1-biguanidino] butanoic acid (DM-212) and 5-[5-(3,4-dichlorobenzyl)-1-biguanidino] pentanoic acid (DM-213). 3. The predominant radioactive substances in the excreta were DM-213 and DM-210 at 26.1% and 25.5%, respectively, of the dose. No unchanged compound was detected in the urine, and in the faeces it was only 2% of the dose.

Published
1998
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9. B. レーザー装置

Author

Masahiro Sakai, Shinji Nagai, Akihiro Kono, Toshio Goto, Hideo Furuhashi, Yoshiyuki Uchida, W. Sasaki, Y. Kometani, J. Kawanaka, S. Kubodera, M. Kaku, H. Tanaka, H. Shimada, F. Wani, M. Endo, S. Takeda, K. Nanri, T. Fujioka, T. Kawano, D. Sugimoto, M. Kawakami, S. Nagatomo, K. Umehara, K. Sunago, Y. Tokura, M. Nakazawa, S. Fukuda, M. Kusaba, Y. Tsunawaki, N Ohigashi, M. Fujita, K Imasaki, K. Mima, K. Ohkubo, H. Furukawa, S. Nakai, C. Yamanaka, Y. Okuda, A. Ohta, K. Naokawa, M. Kiyochi, Hidehiro Tanaka, Prabir Kumar Roy, Ahsa Moon, Eisaku Sano, Naoya Nakao, Taro KUTSUKAKE, Masanori KINUGASA, Shigeru YAMAGUCHI, N. Uehigashi, M. Yamanaka, K. Wada, Yashuhiro Naito, Hiroshi Nagano, Toru Hasuike, Manabu Taniwaki, Kouki Shimizu, Shunichi Sato, Youichi Takashima, Michio Nakayama, Hiroshi Yuasa, Katsuhiko Tsuno, Minoru TAKIZATA, Yasushi KONISHIA, Shigeo HATAKEYAMAA, Deyuan Shen, Anping Liu, Ken-ichi Ueda, H. Kiriyama, K. Nishida, N. Hiura, T. Ichii, H. Matsui, Y. Izawa, T. Yamanaka, U. Kubo, T. Kanzaki, H. Miyajima, M. Miyamoto, H. Kan, Kazunori Okino, Hirofumi Imai, Hitoki Yoneda, Akitoshi UEDA, S. Monma, N. Saito, K. Akagawa, Y. Urata, S. Wada, H. Tashiro, Corinne Droz, H. Kouta, Y. Kuwano, K. Matsubara, U. Tanaka, H. Imajo, K. Hayasaka, R. Ohmukai, M. Watanabe, S. Urabe, J. Kobayashi, H. Nishioka, and N. Takei

Published
1998
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10. A CMOS image sensor with analog two-dimensional DCT-based compression circuits for one-chip cameras

Author

D. Miyazaki, Akira Matsuzawa, S. Doushou, Masaaki Sasaki, K. Umehara, M. Yoshida, Yoshiaki Tadokoro, Shoji Kawahito, and K. Murata

Subjects
Computer science, Quantization (signal processing), ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Data_CODINGANDINFORMATIONTHEORY, Analog image processing, CMOS, Discrete cosine transform, Electronic engineering, Electrical and Electronic Engineering, Image sensor, Quantization (image processing), Analog device, Image compression, Data compression
Abstract

This paper presents a CMOS image sensor with on-chip compression using an analog two-dimensional discrete cosine transform (2-D DCT) processor and a variable quantization level analog-to-digital converter (ADC). The analog 2-D DCT processor is essentially suitable for the on-sensor image compression, since the analog image sensor signal can be directly processed. The small and low-power nature of the analog design allows us to achieve low-power, low-cost, one-chip digital video cameras. The 8/spl times/8-point analog 2-D DCT processor is designed with fully differential switched-capacitor circuits to obtain sufficient precision for video compression purposes. An imager array has a dedicated eight-channel parallel readout scheme for direct encoding with the analog 2-D DCT processor. The variable level quantization after the 2-D DCT can be performed by the ADC at the same time. A prototype CMOS image sensor integrating these core circuits for compression is implemented based on triple-metal double-polysilicon 0.35-/spl mu/m CMOS technology. Image encoding using the implemented analog 2-D DCT processor to the image captured by the sensor is successfully performed. The maximum peak signal-to-noise ratio (PSNR) is 36.7 dB.

Published
1997
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12. Risk factors affecting third molar autotransplantation in males: a retrospective survey in dental clinics

Author

K, Yoshino, N, Kariya, D, Namura, I, Noji, K, Mitsuhashi, H, Kimura, A, Fukuda, I, Kikukawa, T, Hayashi, N, Yamazaki, M, Kimura, K, Tsukiyama, K, Yamamoto, A, Fukuyama, D, Hidaka, J, Shinoda, H, Mibu, Y, Shimakura, A, Saito, S, Ikumi, K, Umehara, F, Kamei, H, Fukuda, T, Toake, Y, Takahashi, Y, Miyata, S, Shioji, M, Toyoda, N, Hattori, H, Nishihara, R, Matsushima, M, Nishibori, O, Hokkedo, M, Nojima, T, Kimura, M, Fujiseki, S, Okudaira, K, Tanabe, M, Nakano, K, Ito, M, Kuroda, and T, Matsukubo

Subjects
Adult, Male, Tooth Ankylosis, Root Resorption, Dental Abutments, Dental Caries, Transplantation, Autologous, Tooth Fractures, Young Adult, Postoperative Complications, Sex Factors, Risk Factors, Periodontal Attachment Loss, Humans, Tooth Root, Tooth Socket, Periodontitis, Aged, Retrospective Studies, Crowns, Smoking, Age Factors, Middle Aged, Survival Analysis, Root Canal Therapy, Treatment Outcome, Tooth Extraction, Molar, Third, Follow-Up Studies
Abstract

The aim of this study was to investigate the risk factors affecting long-term prognosis of autotransplantation of third molars with complete root formation in males at dental clinics. Participating dentists were requested to provide information on transplantations they had undertaken from 1 January 1990 to 31 December 2010. Data on a total of 708 teeth from 637 patients were collected. After data screening and elimination, participants of this study consisted of 183 teeth of 171 males ranging from 20 to 72 years of age (mean age, 44·8 years). The cumulative survival rate was 86·0% at the 5-year mark, 59·1% at 10 years and 28·0% at 15 years. The mean survival time was 134·5 months, as calculated by the Kaplan-Meier method. Single factor analysis using the log-rank test showed that the following factors had significant influence (P0·05) on survival of transplanted teeth: periodontal disease as the reason for recipient site tooth extraction, fewer than 25 present teeth and Eichner index Groups B1 to C. Cox regression analysis examined five factors: age, smoking habit, recipient site extraction caused by periodontal disease, fewer than 25 present teeth and Eichner index. This analysis showed that two of these factors were significant: fewer than 25 present teeth was 2·63 (95% CI, 1·03-6·69) and recipient site extraction caused by periodontal disease was 3·80 (95% CI, 1·61-9·01). The results of this study suggest that long-term survival of transplanted teeth in males is influenced not only by oral bacterium but also by occlusal status.

Published
2012

13. Abstracts from the sixth meeting of the international association of pancreatology, November 2–4, 1994, Chicago, IL

Author

Michael Burdick, Tony Hollingsworth, S. Gansauge, F. Gansauge, K. H. Link, M. H. Schoenberg, B. Poch, H. G. Beger, A. C. C. Wagner, H. Steffen, B. Göke, H. Y. Gaisano, L. Sheu, J. K. Foskett, W. S. Trimble, Y. L. Lee, H. Y. Kwon, H. S. Park, S. M. Lee, H. J. Park, S. aguchi, G. M. Green, K. Mitamura, Y. Komatsu, I. Arai, H. Yamaura, OJ Wang, TE Adrian, S. Teyssen, W. Niebel, E. Niebergall, M. V. Singer, K Umehara, T Ohara, K Kataoka, H Okamura, M Kato, J Sakagami, A Ohta, M Murase, M Hosoda, Y Yamane, K Kashima, Y Ibata, Emil J. Balthazar, P. A. Banks, S. G. Garzof, R. E. Langevin, S. G. Silverman, G. T. Sica, C. Bassi, A. Benini, A. Muner, M. Falconi, H. Abbas, P. Pederzoli, R. Salvia, E. Bertazzoni Minelli, S. Shanmuga Shaskar, M. G. Shearer, C. W. Imrie, G. J. Brodmerkel, P. A. Reed, DL Carr-Locke, A Musa, DR Lichtenstein, J Van Dam, PA Banks, S. Eisele, M. Böchjer, Th. Foitzik, C. Fern’andez-del Castillo, D. W. Rattner, M. J. Ferraro, A. L. Warshaw, J. Schmidt, H. Hotz, H. J. Buhr, E. Klar, A. Heinisch, R. Kadow, U. Bioss, J. Schölmerich, H. Zimgibl, H. -G. Leser, G. Manes, P. G. Rabitti, M. Laccetti, A. Cavallera, L. Paceili, G. Gagiione, G. Uomo, A. Marinqhini, A. R. Zinsmeister, L. J. Melton, E. P. DiMagno, F. Marotta, D. H. Chui, G. Barbi, G. G. Zhong, H. Tajiri, O. Bellini, C McKay, J. N. Baxter, K. Mithöfer, C. Fern’andez-delCastillo, T. W. Frick, K. Lewandrowski, R. Pezzilli, P. Billi, R. Miniero, L. Gullo, B. Barakat, M. Migliuli, B. Rau, M. Schad, M. Schoenberg, F. Richter, R. Matthias, M Imoto, T Ashihara, D Schofield, NM Sharer, KM Heywood, HM Waters, JM Braganza, P Scott, D Bilton, D Deardon, S Lee, PM Taylor, RF McCloy, J. Shen, H. Shao, Z. P. Wu, J. J. Jin, N Shiel, O Cassidy, H Sharma, J. M. Braganza, F. Soöckmann, J. Ahrens, U. Leonhardt, J. Otto, U. Ritzel, G. Ramadori, Fuzhou Tian, JZ Hu, DR Huang, XH Wang, HW Lian, BY Zhang, JG Miao, Xu Li, HT Zhou, P. Esposico, F. Perrocti, M. Visconci, M. I. Vaccaro, M. A. Dagrosa, M. I. Mora, D. O. Sordelli, W. Vogt, H. MeOmann, A. Linseis, A. Holstege, M. R. Weiser, S. A. L. Gibbs, H. B. Hechcman, F. D. Moore, H. V. Worthington, L. P. Runt, R. F. HcCloy, I. A. KacLennan, J. M. Braqanza, D Heath, D Alexander, C Wilson, M Larvin, CW Imrie, MJ McMahon, J Ward, PJ Robinson, AG Chalmers, M Apte, J Wilson, G McCaughan, M Korsten, I Norton, R Piroia, D. Bimmler, G. A. Scheele, Dale E. Bockman, Markus Büchler, Hans G. Beger, G. Cavallini, M. P. Brunori, L. Rigo, P. Bovo, M. Filippini, B. Vaona, V. Di Francesco, L. Frulloni, M. Marcori, P. C. Farri, M. T. Laardini, Riaz Chowdhury, Koji Ochi, Takaaki Mizushima, Tetsuya Tsurumi, Hideo Harada, P. Laver, J. J. Hoist, M. v. d. Ohe, H. Goebell, A. Mi Zumoto, M. G. Sarr, R. Moore, C. F. Frey, H. T. Debas, S. J. Mulvihill, S. Onizuka, H. Kuroda, Y. Kuroda, H. Hongo, S. Matsuzaki, M. Ito, L. Sekine, T. Tsunoda, ’A. Pap, V. Hrisztov, E. Marosi, K. Simon, T. Tak’acs, A. Bonora, G. Talamini, R. Saivia, L. Benini, E. Caldiron, S. Vesentini, Isaac Raijman, Paul Kortan, Gregory B. Haber, H Ramesh, CJ Varghese, PM Kay, T Bottiglieri, S Uden, A Gut, I Segal, C Snehalatha, V Mohan, E. Silva, R. Ceneviva, M. A. L. Velludo, E. Silvan, B. Ruebner, J. E. S. Roselino, M. C. Foss, G. Talaraini, M. Falcaoi, L Frmlltai, V. K Fraacesca, M. Maxwi, B. Vaosa, P. Baro, C. Baxu, P. Pedercoli, G. Cavalliai, G. Taiamini, C. Iacano, M. Faicsai, L. Rige, A. Castagnisi, G. Angelini, P. Bom, B. Vaoss, I. Vantini, G. Sen, P. Pederzali, B Štimee, M Bulajič, T Milosavljevi’c, R Krsti’c, M Markovi’c, V Korneti, M Ugljcš’c, IL Abruzzesse, DB Evans, L Larry, T King, I Raijman, L Roubein, M Frazier, C. lacono, E. Faca, G. Falezza, E. Bonora, PP Aurola, G. Serio, N. Nicoli, G. C. Mansueto, M. Zicari, L. Marchiori, G. Mangiante, G. Seno, M. Imarnura, H. Yamauchi, M. Inoue, M. Onda, E. UchlDa, T. Almqtq, Y. Yamanaka, T. Kqbayashi, T. Yokqyama, K. Aida, K. Sasajima, T. Tajiri, K. Egami, K. Yamashita, Z. Naitq, G. Asano, K. B. Lewandrowski, R. E. Kirby, J. F. Southern, C. C. Compton, J Lip, L Strömmer, J Permert, J Larsson, E. V. Loftus, M. C. Adkins, B. Olivares-Pakzad, K. P. Batts, D. H. Stephens, M. B. Farnell, H. G. Sarr, G. B. Thompson, J. A. van Heerden, D. G. Kelly, L. J. Miller, R. K. Pearson, J. E. Clain, B. T. Petersen, Cancer S. Matsumoto, R. Chowdhury, T. Mizushima, K. Ochi, H. Harada, H. Miki, Hnsan Ozkan, Hiromitsu Saisho, Taketo Yarnaguchi, Takeshi Ishihara, Yasuharu Kikuchi, Toshio Tsuyuguchi, Masao Ohto, C. Pasqual, C. Sperti, G. Liesai, M. Guido, S. Pedrazzoli, C. Pasquali, E. Khajeturian, P. Guolo, H. Tadokoro, S. Watanabe, Y. Moriyoshi, K. Yoshida, K. Shiratori, T. Takeuchi, E. Uchida, T. Kobayashi, T. Aimoto, T. Yokoyama, Z. Naito, M. A. Valentich, B. Monis, N. N. Barotto, and P. Herrera

Subjects
medicine.medical_specialty, Endocrinology, Oncology, business.industry, Family medicine, Gastroenterology, medicine, business
Published
1994
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14. The first evidence of a deeply bound state of Xi--14N system

Author

Kazuma Nakazawa, Yoko Endo, S. Fukunaga, Hitoshi Takahashi, S. Ogawa, J. H. Kim, Kazunori Itonaga, Khin Than Tint, S. Kinbara, Kenichi Imai, K. Umehara, S. H. Hwang, K. Hoshino, Myint Kyaw Soe, T. Kanda, H. Shibuya, J. Yoshida, T. Takahashi, M. Kawasaki, Hiroki Ito, C. S. Yoon, Akihiro Mishina, Hidetaka Kobayashi, and T. Sugimura

Subjects
Nuclear physics, Physics, Science research, Bound state, General Physics and Astronomy, Humanities
Abstract

The first evidence of a deeply bound state of Xi−–14N system K. Nakazawa1,∗, Y. Endo1, S. Fukunaga2, K. Hoshino1, S. H. Hwang3, K. Imai3, H. Ito1, K. Itonaga1, T. Kanda1, M. Kawasaki1, J. H. Kim4, S. Kinbara1, H. Kobayashi1, A. Mishina1, S. Ogawa2, H. Shibuya2, T. Sugimura1, M. K. Soe1, H. Takahashi5, T. Takahashi5, K. T. Tint1, K. Umehara1, C. S. Yoon4, and J. Yoshida1 1Physics Department, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan 2Department of Physics, Toho University, Funabashi 274-8510, Japan 3Advanced Science Research Center, JAEA, Tokai 319-1195, Japan 4Department of Physics, Gyeongsang National University, Jinju 660-701, Korea 5Institute of Particle and Nuclear Studies, KEK, Tsukuba 305-0801, Japan ∗E-mail: nakazawa@gifu-u.ac.jp

Published
2015
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15. AM-coded spectral matching imager using correlation image sensor

Author

A. Fukui, Akira Kimachi, N. Sugita, Y. Kitajima, K. Umehara, and Y. Ishikawa

Subjects
Spectral power distribution, business.industry, Matched filter, Multispectral image, Frame rate, Signal, Amplitude modulation, Optics, Computer Science::Computer Vision and Pattern Recognition, Monochrome, Computer vision, Artificial intelligence, Image sensor, business, Mathematics
Abstract

In the previous report we proposed the spectral matching imager, which, using the correlation image sensor, detects an object having a particular spectral function out of a scene under a typical frame rate. In order to increase power efficiency of the illumination, this paper proposes a type of spectral matching imager that uses AM-coded multispectral illumination instead of the variable wavelength monochrome illumination used previously. The AM-coded multispectral illumination projects a white light each wavelength of which is amplitude-modulated with a different frequency. Using a reference signal created as a weighted average of the AM waveforms of the illumination in which the weights are the values of a reference spectral function sampled at corresponding wavelengths, the imager outputs pixelwise spectral correlation between the object and the reference, due to orthogonality of the sinusoidal AM waveforms. The theory and an implementation of the imager are described.

Published
2003
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16. A compressed digital output CMOS image sensor with analog 2-D DCT processors and ADC/quantizer

Author

S. Kawahito, M. Yoshida, M. Sasaki, K. Umehara, Y. Tadokoro, K. Murata, S. Doushod, and A. Matsuzawa

Subjects
business.product_category, Computer science, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Image processing, Video camera, Data_CODINGANDINFORMATIONTHEORY, Analog image processing, law.invention, law, Digital image processing, Discrete cosine transform, Computer vision, Smart camera, Image sensor, Digital camera, Lossless compression, Signal processing, business.industry, Quantization (signal processing), Camera interface, Artificial intelligence, business, Encoder, Computer hardware, Image compression, Data compression
Abstract

Progress in CMOS-based image sensors is creating opportunities for a low-cost, low-power one-chip video camera with digitizing, signal processing and image compression. Such a smart camera head acquires compressed digital moving pictures directly into portable multimedia computers. Video encoders using a moving picture coding standard such as MPEG and H.26x are not always suitable for integration of image encoding on the image sensor, because of the complexity and the power dissipation. On-sensor image compression such as a CCD image sensor for lossless image compression and a CMOS image sensor with pixel-level interframe coding are reported. A one-chip digital camera with on-sensor video compression is shown in the block diagram. The chip contains a 128/spl times/128-pixel sensor, 8-channel parallel read-out circuits, an analog 2-dimensional discrete cosine transform (2D DCT) processor and a variable quantization-level ADC (ADC/Q).

Published
2002
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17. Posture control of moving object using two mechanical artificial feelers

Author

Y. Takahashi and K. Umehara

Subjects
Surface (mathematics), Engineering, business.industry, Control (management), Robot, Geodetic datum, Computer vision, Artificial intelligence, business, Object (computer science)
Abstract

The posture control of a moving object by using two mechanical artificial feelers is proposed. The moving object runs along a datum surface by controlling the distance and angle to the datum surface. The two mechanical feelers touch the datum surface as a L-shape guide. The distance and angle to the datum surface are calculated by the angles of the two mechanical feelers. An installation and an adjustment are easy. The posture of the moving object will be controlled by the proposed scheme. This paper describes the concept and design method of the proposed posture control. The validity of the proposed control scheme has been confirmed by the experimental results.

Published
2002
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18. In vitro characterization of the oxidative cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes

Author

K, Umehara, S, Kudo, Y, Hirao, S, Morita, T, Ohtani, M, Uchida, and G, Miyamoto

Subjects
Dogs, Anti-Infective Agents, Biguanides, Microsomes, Liver, Animals, Enzyme Inhibitors, In Vitro Techniques, Oxidation-Reduction, Biotransformation, Chromatography, High Pressure Liquid
Abstract

The metabolism of olanexidine [1-(3,4-dichlorobenzyl)-5-octylbiguanide], a new potent biguanide antiseptic, was investigated in dog liver microsomes to characterize the enzyme(s) catalyzing the biotransformation of olanexidine to C-C bond cleavage metabolites. Olanexidine was initially biotransformed to monohydroxylated metabolite 2-octanol (DM-215), and DM-215 was subsequently oxidized to diol derivatives threo-2,3-octandiol (DM-221) and erythro-2,3-octandiol (DM-222). Diols were further biotransformed to a ketol derivative and C-C bond cleavage metabolite (DM-210, hexanoic acid derivative), an in vivo end product, in the incubation with dog liver microsomes. The formations of DM-215, DM-221, DM-222, and DM-210 followed Michaelis-Menten kinetics, and Eadie-Hofstee analysis of the metabolite formation activity confirmed single-enzyme Michaelis-Menten kinetics. The K(m) and V(max) values for the formation of DM-210 appeared to be 2.42 microM and 26.6 pmol/min/mg in the oxidation of DM-221 and 2.48 microM and 30.2 pmol/min/mg in the oxidation of DM-222. The intrinsic clearance (V(max)/K(m)) of the C-C bond cleavage reactions was essentially the same with either DM-221 or DM-222 as substrate. These oxidative reactions were significantly inhibited by quinidine, a selective inhibitor of CYP2D subfamilies, indicating the metabolic C-C bond cleavage of the octyl side chain of olanexidine to likely be mediated via the CYP2D subfamily in dog liver microsomes. This aliphatic C-C bond cleavage by cytochrome P450s may play an important role in the metabolism of other drugs or endogenous compounds possessing aliphatic chains.

Published
2000

19. Oxidative cleavage of the octyl side chain of 1-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045) in rat and dog liver preparations

Author

K, Umehara, S, Kudo, Y, Hirao, S, Morita, M, Uchida, M, Odomi, and G, Miyamoto

Subjects
Chlorobenzoates, Male, Rats, Sprague-Dawley, Dogs, Liver, Species Specificity, Biguanides, Microsomes, Liver, Animals, In Vitro Techniques, Oxidation-Reduction, Chromatography, High Pressure Liquid, Rats
Abstract

The metabolism of 1-(3,4-dichlorobenzyl)-5-octylbiguanide (OPB-2045), a new potent biguanide antiseptic, was investigated using rat and dog liver preparations to elucidate the mechanism of OPB-2045 metabolite formation, in which the octyl side chain is reduced to four, five, or six carbon atoms. Chemical structures of metabolites were characterized by 1H NMR, fast atom bombardment/mass spectrometry, and liquid chromatography/electrospray ionization-tandem mass spectrometry. Three main metabolites were observed during incubation of OPB-2045 with rat liver S9: 2-octanol (M-1), 3-octanol (M-2), and 4-octanol (M-3). In the incubation of OPB-2045 with dog liver S9, eight metabolites were observed, seven of which being M-1, M-2, M-3, 2-octanone (M-4), threo-2,3-octandiol (M-5), erythro-2,3-octandiol (M-6), and 1,2-octandiol (M-7). M-5 and M-6 were further biotransformed to a ketol derivative and C-C bond cleavage metabolite (hexanoic acid derivative), an in vivo end product, in the incubation with dog liver microsomes. The reactions required NADPH as a cofactor and were significantly inhibited by the various inhibitors of cytochrome P450 (i.e., CO, n-octylamine, SKF 525-A, metyrapone, and alpha-naphthoflavone). The results indicate that the degraded products of OPB-2045 are produced by C-C bond cleavage after monohydroxylation, dihydroxylation, and ketol formation at the site of the octyl side chain with possible involvement of cytochrome P450 systems. This aliphatic C-C bond cleavage by sequential oxidative reactions may play an important role in the metabolism of other drugs or endogenous compounds that possess aliphatic chains.

Published
2000

20. Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation

Author

S, Kudo, K, Umehara, M, Hosokawa, G, Miyamoto, K, Chiba, and T, Satoh

Subjects
Isoenzymes, Kinetics, Dose-Response Relationship, Drug, Microsomes, Liver, Humans, Phenacetin, Enzyme Inhibitors, Carboxylic Ester Hydrolases, Flutamide
Abstract

Microsomal and cytosolic phenacetin deacetylase activities were examined in human liver and kidneys. Kinetic properties of the activities were also studied in human liver microsomes. Phenacetin deacetylase activity was predominantly localized in the liver microsomal fraction. The specific activities of phenacetin deacetylation in liver cytosol and in kidney microsomes and cytosol were all less than 5% of that in liver microsomes. In human liver microsomes, Eadie-Hofstee plots for phenacetin deacetylation were monophasic, indicating a single-enzyme catalytic reaction. The Michaelis-Menten parameters, K(m) and V(max), for the deacetylation were 4.7 mM and 5.54 nmol/min/mg of protein, respectively. The intrinsic clearance, calculated as V(max)/K(m), was 1.18 microl/min/mg of protein. Although the organophosphate bis(4-nitrophenyl)phosphoric acid markedly inhibited the reaction in human liver microsomes, the activity has a tolerance to the treatment of phenylmethylsulfonyl fluoride, a serine hydrolase inhibitor. Prazosin, a peripheral alpha(1)-adrenergic antagonist, noncompetitively inhibited the phenacetin deacetylation with a K(i) value of 19.0 microM. Flutamide, a nonsteroidal androgen receptor antagonist, stimulated the activity by up to 349%. This increase was accompanied by a decrease in the K(m) value and no change in the V(max) value, resulting in an increase in the intrinsic clearance by up to 700% of the control. These results suggest that the phenacetin deacetylase localized in human liver microsomes has not only a catalytic site but also a negative and/or positive modulation site or sites.

Published
2000

21. CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line

Author

Y, Nishii, M, Morishima, Y, Kakehi, K, Umehara, N, Kioka, Y, Terano, T, Amachi, and K, Ueda

Subjects
DNA, Complementary, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Molecular Sequence Data, Tumor Cells, Cultured, Humans, Nuclear Proteins, Amino Acid Sequence, RNA, Messenger, Cisplatin, DNA Primers
Abstract

A novel putative SR protein, designated cisplatin resistance-associated overexpressed protein (CROP), has been cloned from cisplatin-resistant cell lines by differential display. The N-half of the deduced amino acid sequence of 432 amino acids of CROP contains cysteine/histidine motifs and leucine zipper-like repeats. The C-half consists mostly of charged and polar amino acids: arginine (58 residues or 25%), glutamate (36 residues or 16%), serine (35 residues or 15%), lysine (30 residues, 13%), and aspartate (20 residues or 9%). The C-half is extremely hydrophilic and comprises domains rich in lysine and glutamate residues, rich in alternating arginine and glutamate residues, and rich in arginine and serine residues. The arginine/serine-rich domain is dominated by a series of 8 amino acid imperfect repetitive motif (consensus sequence, Ser-Arg-Ser-Arg-Asp/Glu-Arg-Arg-Arg), which has been found in RNA splicing factors. The RNase protection assay and Western blotting analysis indicate that the expression of CROP is about 2-3-fold higher in mRNA and protein levels in cisplatin-resistant ACHN/CDDP cells than in host ACHN cells. CROP is the human homologue of yeast Luc7p, which is supposed to be involved in 5'-splice site recognition and is essential for vegetative growth.

Published
2000

22. A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression

Author

M, Ogawa, K, Umehara, W G, Yu, Y, Uekusa, C, Nakajima, T, Tsujimura, T, Kubo, H, Fujiwara, and T, Hamaoka

Subjects
Male, Mice, Inbred BALB C, Mice, Inbred C3H, T-Lymphocytes, Vascular Cell Adhesion Molecule-1, Neoplasms, Experimental, Intercellular Adhesion Molecule-1, Interleukin-12, Mice, Inbred C57BL, Mice, Cell Movement, Tumor Cells, Cultured, Animals, Female
Abstract

Interleukin (IL) 12 has been shown to elicit tumor regression when this cytokine induces the migration of T cells to tumor sites. The present study investigates the role of a peritumoral stromal reaction in IL-12-induced T-cell migration. In the CSA1M and OV-HM tumor models, IL-12 treatment induced tumor regression that is associated with T-cell migration. Neither T-cell migration nor tumor regression was observed in the Meth A and MCH-1-A1 models. Stromal tissue containing neovascular blood vessels developed at the peritumoral area of the former two IL-12-responsive tumors but not at the peritumoral area of the latter two IL-12-unresponsive tumors. The significance of stroma development was investigated using a pair of tumor models (CSA1M and a subline derived from CSA1M designated the CSA1M variant), both of which exhibit the same tumor immunogenicity. In contrast to the parental CSA1M cell line, the variant cell line was not responsive to IL-12, and neither stroma development nor T-cell migration was observed, even after IL-12 treatment. Histological analyses revealed that the parental cell line had peritumoral stroma with intrastromal vessels but only a few vessels in tumor parenchyma, whereas the variant cell line showed no stroma but had abundant vasculature in the tumor parenchyma. Most importantly, only stromal vessels in the parental tumors expressed detectable and enhanced levels of vascular cell adhesion molecule 1 (VCAM-1)/ intercellular adhesion molecule 1 (ICAM-1) before and after IL-12 treatment, respectively. In contrast, parenchymal vasculature in the variant cell line failed to express VCAM-1/ICAM-1 even after IL-12 treatment. When transferred into recipient tumor-bearing mice, IL-12-stimulated T cells from the parental CSA1M-bearing or the variant CSA1M-bearing mice migrated into the parental but not into the variant tumor mass. Together with our previous finding that T-cell migration depends on the VCAM-1/ICAM-1 adhesive interactions, the present results indicate a critical role for peritumoral stroma/stromal vasculature in the acceptance of tumor-infiltrating T cells that is a prerequisite for IL-12-induced tumor regression.

Published
1999

23. The Impact of High Cell Density Ceramic Substrates and Washcoat Properties on the Catalytic Activity of Three Way Catalysts

Author

Lothar Mussmann, D. Lindner, A. Kunz, M. Makino, Anton Waltner, K.P. Biehn, J.A.A. van den Tillaart, J. Schmidt, Wilfried Mueller, A. Wirth, K. Umehara, A. Hirschmann, Gunter Loose, and J. Gieshoff

Subjects
Materials science, Chemical engineering, visual_art, Three way, visual_art.visual_art_medium, High cell, Ceramic, Catalysis
Published
1999
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26. Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression

Author

M, Ogawa, W G, Yu, K, Umehara, M, Iwasaki, R, Wijesuriya, T, Tsujimura, T, Kubo, H, Fujiwara, and T, Hamaoka

Subjects
Male, Ovarian Neoplasms, Mice, Inbred BALB C, Neovascularization, Pathologic, Fibrosarcoma, T-Lymphocytes, Remission Induction, Antibodies, Monoclonal, Down-Regulation, Vascular Cell Adhesion Molecule-1, Antineoplastic Agents, Neoplasms, Experimental, Intercellular Adhesion Molecule-1, Interleukin-12, Rats, Mice, Inbred C57BL, Interferon-gamma, Mice, Cell Movement, Tumor Cells, Cultured, Animals, Female
Abstract

Administration of recombinant interleukin 12 (IL-12) induces tumor regression that is associated with T-cell infiltration in the OV-HM ovarian carcinoma and CSA1M fibrosarcoma models. After confirming the blocking of regression by injection of anti-IFN-gamma monoclonal antibody (mAb), we investigated the mechanisms underlying the requirement of IFN-gamma in T-cell migration and tumor regression. T-cell migration was inhibited by injection of anti-IFN-gamma mAb to OV-HM tumor-bearing mice prior to IL-12 treatment. We examined, using the lymphoid cell migration assay, whether IFN-gamma is required for enhancing the migratory capacity of T cells or the T cell-accepting potential of tumor masses during IL-12 treatment. Spleen cells from IL-12-treated or untreated OV-HM-bearing mice were stained in vitro with a fluorescein chemical and transferred i.v. into OV-HM-bearing mice that were not treated with IL-12. Migration of donor cells was quantitated by counting the number of fluorescent cells on cryostat sections of tumor masses from recipient mice. Compared to spleen cells from OV-HM-bearing mice that were not treated with IL-12, enhanced migration was observed for cells from IL-12-treated OV-HM-bearing mice. Anti-IFN-gamma pretreatment of donor mice before IL-12 treatment did not reduce the migratory capacity of T cells, whereas migration was markedly inhibited in recipient mice injected with anti-IFN-gamma. Anti-IFN-gamma pretreatment decreased vascular cell adhesion molecule-1 (VCAM-1)-/intercellular adhesion molecule-1 (ICAM-1)-positive blood vessels at tumor sites. Consistent with this, migration was also inhibited by treatment of recipient mice with either anti-VCAM-1 or anti-ICAM-1 mAb. In contrast to the OV-HM model, T-cell migration was not affected in the CSA1M model following preinjection of anti-IFN-gamma mAb. In this model, VCAM-1-/ICAM-1-positive blood vessels existed even after anti-IFN-gamma treatment, although tumor regression was completely inhibited. These results indicate that IFN-gamma plays two distinct roles in expressing the antitumor efficacy of IL-12: one is to support the T-cell acceptability of tumor masses, and the other is to mediate the antitumor effects of migrated T cells.

Published
1998

28. [Recent progress in the diagnosis of gastroesophageal varices]

Author

S, Matsutani, H, Maruyama, G, Sato, T, Suzuki, K, Umehara, and H, Saisho

Subjects
Gastroscopy, Hypertension, Portal, Angiography, Humans, Ultrasonography, Doppler, Esophagoscopy, Esophageal and Gastric Varices
Abstract

Recent advances in the diagnosis of gastroesophageal varices are reviewed in this paper. Endoscopy, angiography, ultrasound, and ultrasound Doppler are now employed in the diagnosis of varices. As for endoscopic diagnosis, new criteria for the evaluation of gastroesophageal varices have been applied. Angiography is now not only used to demonstrate the varices and collateral circulations in portal hypertension but also used in the embolization therapy for large gastric varices or intractable esophageal varices. Ultrasound and color Doppler are now widely used in the diagnosis of portal hypertension because of its noninvasiveness and conveniency. Furthermore, in its use in endoscopy, varical vessels and blood flow in the wall of the esophagus and the stomach can be directly demonstrated. Recent advances in these diagnostic modalities will made it possible to diagnose gastroesophageal varices and evaluate the pathophysiology in patients with portal hypertension more precisely.

Published
1996

29. [Localization of NADPH-diaphorase activity and NOS immunoreactivity in the pancreas of rat and dog]

Author

K, Umehara

Subjects
Male, Dogs, Species Specificity, NADPH Dehydrogenase, Animals, Nitric Oxide Synthase, Rats, Wistar, Nitric Oxide, Immunohistochemistry, Pancreas, Rats
Abstract

To clarify the role of nitric oxide (NO) in the pancreas, we investigate the localization of NADPH-diaphorase activity and neuronal nitric oxide synthase (nNOS) immunoreactivity in the pancreas of the rat and dog. NADPH-diaphorase activity and nNOS immunoreactivity were identical in the neuronal element of both species. NADPH-diaphorase activity and nNOS immunoreactivity were localized in neurons and endothelial cells of vascular system. Numerous NADPH-diaphorase positive and nNOS immunoreactive fibers were observed around pancreatic ducts and arteries. A moderate number of NADPH-diaphorase positive and nNOS immunoreactive fibers were observed surrounding the acini of dog pancreas, but there were few of these structures in rat pancreas. The islets of the rat pancreas contained a moderate number of NADPH-diaphorase positive and nNOS immunoreactive fibers. However in the dog, these positive fibers were not detected inside the islets. In the rat pancreas, 85% of the ganglion cells showed NADPH-diaphorase staining. In the dog, however, 30-50% of the ganglion cells demonstrated NADPH-diaphorase activity. Although NADPH-diaphorase histochemistry did not show any positive staining in the islet cells of pancreas in either species, NOS immunocytochemical method demonstrated weak positive staining in the rat islet cells. These results indicate that NO may play an important role for the neuronal regulation of pancreatic exocrine and endocrine activities in both species, but in the species-specific manner.

Published
1995

30. Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex

Author

R, Yamazaki, J, Sugatani, I, Fujii, M, Kuroyanagi, K, Umehara, A, Ueno, Y, Suzuki, and M, Miwa

Subjects
Male, Acetyltransferases, Plant Extracts, Biphenyl Compounds, Animals, Humans, Reproducibility of Results, In Vitro Techniques, Rats, Wistar, Lignans, Rats
Abstract

A method was developed for determining the activity of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (EC 2.3.1.67), a key enzyme in the biosynthesis of platelet-activating factor (PAF, 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine). The assay involves measurement of the radioactivity in the trichloroacetic acid (TCA)-precipitated complex of radioactive product and albumin after incubation of 1-alkyl-sn-glycero-3-phosphocholine and [3H]acetyl-CoA with rat spleen microsomes or membrane fractions of human polymorphonuclear leukocytes (PMNs). The radioactive product associated with the precipitate was identified as PAF using an ultrahigh-sensitivity TV camera system after extraction and separation by TLC. This TCA method was then used to screen the components of crude preparations that inhibited acetyltransferase activity. Major components from the cortex of Magnoliae (magnolol and honokiol), which have anti-inflammatory and anti-bacterial actions, inhibited the acetyltransferase activity in rat spleen microsomes (IC50, 150 and 150 microM, respectively) and membrane fractions of human PMNs (IC50, 70 and 60 microM, respectively). The inhibitory action of magnolol and honokiol was reversible, and similar to or higher than that of nordihydroguaiaretic acid. PAF production in human PMNs stimulated by the ionophore A23187 was also suppressed dose dependently by magnolol and honokiol. These activities may be relevant to the claimed therapeutic effects of the extract from Magnoliae cortex.

Published
1994

31. Biphenomycin A production by a mixed culture

Author

M Ezaki, T Komori, M Iwami, H Imanaka, K Umehara, and M Yamashita

Subjects
Applied Microbiology and Biotechnology, Microbiology, chemistry.chemical_compound, Biosynthesis, Pseudomonas, Streptomyces griseorubiginosus, Bacteriological Techniques, Ecology, biology, Streptomycetaceae, Dipeptides, biology.organism_classification, Streptomyces, Anti-Bacterial Agents, Biochemistry, chemistry, Evaluation Studies as Topic, Pseudomonadales, Actinomycetales, Peptides, Bacteria, Food Science, Biotechnology, Pseudomonadaceae, Antimicrobial Cationic Peptides, Research Article
Abstract

Production of biphenomycin A by Streptomyces griseorubiginosus 43708 was stimulated by a mixed culture with a partner strain, Pseudomonas maltophilia 1928. This stimulatory effect on biphenomycin A accumulation by the mixed culture was caused by the enzyme activity which strain 1928 possessed. It is suggested that in a mixed culture strain 43708 produces a precursor of biphenomycin A in culture broth and that strain 1928 converts the precursor to biphenomycin A.

Published
1992

33. Murine cytomegalovirus infection model in Balb/c mice. 3. Immunoglobulin production during infection

Author

W C, Leung, K, Hashimoto, K, Umehara, and J, Hata

Subjects
Male, Mice, Inbred BALB C, Time Factors, Cytomegalovirus, Immunoglobulins, Antibodies, Viral, Immunoglobulin A, Disease Models, Animal, Mice, Immunoglobulin M, Neutralization Tests, Immunoglobulin G, Cytomegalovirus Infections, Animals, Antibody-Producing Cells, Spleen
Abstract

In mice infected with a lethal dose of murine cytomegalovirus (MCMV) the serum immunoglobulin (Ig) levels and the Ig-bearing cells in the spleen dropped to barely detectable levels 2 days after infection. In mice with acute but non-lethal MCMV infection, the serum IgM was twice and the IgG 32 times that of the uninfected controls by Day 8 of infection; the numbers of spleen cells bearing IgM and the IgG subclasses (IgG1, IgG2a, IgG2b, IgG3) were also greatly increased. In the asymptomatically infected group, serum IgM remained unchanged but the IgG increased to 16 times that of uninfected controls by Day 11 of infection; the numbers of spleen cells bearing IgM and IgG subclasses were also increased, although to a lesser extent than in the acute, non-lethally infected mice. In the latter two groups, serum IgA and IgA-bearing cells in the spleen did not alter significantly. Complement-requiring neutralizing antibodies to MCMV were detected 8 days post infection.

Published
1991

34. Immunological responses in germfree mice infected with murine cytomegalovirus

Author

S, Tazume, K, Umehara, W C, Leung, K, Ando, T, Yoshida, and K, Hashimoto

Subjects
Killer Cells, Natural, Mice, Mice, Inbred ICR, Antibody Formation, Cytomegalovirus Infections, Animals, Germ-Free Life, Female, Lymphocyte Activation, Spleen, Specific Pathogen-Free Organisms
Abstract

The immunological response of spleen cells was examined during murine cytomegalovirus (MCMV) infection of germfree (GF) mice. GF mice were more susceptible to MCMV infection than specific pathogen-free (SPF) mice. Recovery from the acute phase of MCMV infection was delayed in GF mice as compared to SPF mice. During MCMV infection, the immune response of GF mice, measured in terms of mitogen and of antibody response to sheep erythrocytes, was more markedly depressed and the recovery from the depression was more delayed than in SPF mice. In MCMV-infected mice, natural killer (NK) cell activity was increased by day 1 and 2 post-infection, with similar kinetics in GF and SPF mice, suggesting that NK cells may be exerting the most potent antiviral effect during the early stage of MCMV infection.

Published
1990

35. Concurrent murine cytomegalovirus and Klebsiella pneumoniae infections in germfree mice

Author

S, Tazume, K, Umehara, W C, Leung, K, Ando, J, Hata, and K, Hashimoto

Subjects
Klebsiella pneumoniae, Mice, Mice, Inbred ICR, Cytomegalovirus Infections, Animals, Germ-Free Life, Female, Klebsiella Infections, Specific Pathogen-Free Organisms
Abstract

The effects of concurrent murine cytomegalovirus (MCMV) and Klebsiella pneumoniae infections were studied in germfree (GF) mice. The mice received sublethal doses, 5 x 10(5) pfu, of MCMV. K. pneumoniae was injected in doses of 40 to 100 cfu, which by itself killed 0-33% of GF mice. When K. pneumoniae was given to GF mice infected with MCMV, the mortality increased up to 100%, with distinct enhancement persisting until day 10 of the MCMV infection. The virus titer in various organs did not change after superinfection with K. pneumoniae, while the viable counts of K. pneumoniae in organs remained remarkably high until death, suggesting the cause of death to be severe generalized infection by the bacteria. When compared to specific pathogen-free (SPF) mice, GF mice were more susceptible to both MCMV and K. pneumoniae infection, had higher titers of the virus for longer periods in various organs, and showed extension in the duration of enhanced mortality by the bacteria. Histopathologically, the spleen and liver were found to be the most severely affected tissues, more so in GF than in SPF mice, with recovery from the changes being slower in the GF animals.

Published
1990

36. Method for Determining the Coefficient of Permeability of Clays

Author

L David Suits, TC Sheahan, T Moriwaki, and K Umehara

Subjects
Constant rate, Permeability (earth sciences), Pore water pressure, Materials science, Consolidation (soil), Soil test, Compressibility, Geotechnical engineering, Strain rate, Geotechnical Engineering and Engineering Geology, Porosity, complex mixtures
Abstract

A new method for directly determining the coefficient of permeability of clays from the constant rate of strain consolidation tests was proposed by Yoshikuni et al. (1995). In order to confirm the reliability of this method, the constant rate of strain consolidation tests under three kinds of strain rates were carried out on four kinds of clays in this study. The permeability tests using a flow pump and the conventional consolidation tests were also carried out on the same clays for comparing the coefficient of permeability obtained from each test. As the results, it was found that the coefficient of permeability obtained by the proposed method from the constant rate of strain consolidation tests agreed with the coefficient of permeability obtained from the permeability tests.

Published
2003
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37. Development of a high-definition 32-in. PDP

Author

N. Matsui, Tomokatsu Kishi, K. Ohira, K. Kariya, Hideaki Ohki, Fumihiro Namiki, Yuichiro Kimura, K. Umehara, Nobuhiro Iwase, Masaji Ishigaki, Katsuya Kawasaki-shi Irie, J. Okayasu, Takeo Masuda, S. Fujimoto, Tadayoshi Kosaka, Hiroshi Ohtaka, and M. Amatsu

Subjects
High-definition television, Computer science, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Luminance, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Color rendering index, CRTS, Filter (video), Power consumption, Color gel, Computer graphics (images), Electronic engineering, Electrical and Electronic Engineering, Luminous efficacy, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

We developed the world's smallest-profile 32-in. HDTV PDP. By improving the luminous efficiency, a luminance of 650 cd/m 2 and power consumption (discharge and driving circuit) of 200 W or less was achieved. Moreover, incorporating an advanced color compensating (ACC) filter improved the PDP's color-reproduction capability, better than that of CRTs.

Published
2002
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39. 49.1: Development of a Hi-Definition 32-in. PDP

Author

K. Umehara, Hiroshi Ohtaka, Tomokatsu Kishi, J. Okayasu, Hideaki Ohki, N. Matsui, M. Amatsu, Fumihiro Namiki, K. Kariya, Yuichiro Kimura, Masaji Ishigaki, Katsuya Fujitsu Limited Irie, S. Fujimoto, K. Ohira, Nobuhiro Iwase, Takeo Masuda, and Tadayoshi Kosaka

Subjects
Engineering, business.industry, Driving circuit, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Color reproduction, Luminance, CRTS, Power consumption, Filter (video), Electronic engineering, Luminous efficacy, business, Computer hardware, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

We developed the world's smallest 32-inch HDTV PDP. By improving the luminous efficiency, a luminance of 650 cd/m2 and power consumption (discharge and driving circuit) of 200 W or less was achieved. Moreover, incorporating an Advanced Color Compensating (ACC) filter improved the PDP's color reproduction capability, better than that of CRTs.

Published
2001
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41. Effect of bradykinin on pancreatic blood flow in experimental acute pancreatitis

Author

A. Ohta, Yukio Yamane, K. Kashima, J. Sakagami, M. Hosoda, M. Murase, K. Kataoka, T. Fukusima, K. Umehara, and M. Kato

Subjects
medicine.medical_specialty, business.industry, Bradykinin, medicine.disease, Gastroenterology, Pathology and Forensic Medicine, Pancreatic blood flow, chemistry.chemical_compound, chemistry, Physiology (medical), Internal medicine, medicine, Acute pancreatitis, business
Published
1994
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43. A Program of Training in Chemical Pathology for Residents in Pathology

Author

Mary K. Umehara, Edward T. Wong, and Rex E. Sterling

Subjects
Pathology, medicine.medical_specialty, Medical education, Pathology, Clinical, Laboratory management, business.industry, Internship and Residency, General Medicine, California, Hospitals, University, Chemistry, Clinical, Chemical pathology, Medicine, Hardware_CONTROLSTRUCTURESANDMICROPROGRAMMING, business
Abstract

We have developed a new program of instruction in chemical pathology for residents in pathology. The major features that differentiate this new program from its predecessor are: first, an emphasis on principles rather than technical details of biochemical analysis; second, didactic instruction and practical experience in laboratory management and administration; and, third, instruction in interpretation and selection of laboratory tests. The organization, content, instructional approaches and learning objectives are described.

Published
1982
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44. Improved Instrumentation for the Determination of Prothrombin Activity

Author

Rex E. Sterling, Alan A. Wilcox, Arnold G. Ware, and Mary K. Umehara

Subjects
Prothrombin time, Prothrombin.activity, medicine.diagnostic_test, Computer science, Technician, Biochemistry (medical), Clinical Biochemistry, Detector, medicine, Instrumentation (computer programming), Biomedical engineering
Abstract

The one-stage prothrombin method of Ware and Stragnell (2) has been semiautomated. This method employs an automatic pipetter-diluter and an end-point detector. These instruments materially increase the output per technician.

Published
1965
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45. An Automated Determination of Alkaline Phosphatase Utilizing p-Nitrophenol Phosphate

Author

Rex E. Sterling, Arnold G. Ware, Mary K. Umehara, and Alan A. Wilcox

Subjects
Chromatography, Chemistry, P-nitrophenol phosphate, Biochemistry (medical), Clinical Biochemistry, Alkaline phosphatase, Blood alkaline phosphatase, Serum alkaline phosphatase, Production rate
Abstract

A technic is described for the automated determination of serum alkaline phosphatase. This method permits a production rate of 60 determinations per hour on 0.2 ml. of serum per determination. Calculations are simplified since no serum blank is required.

Published
1964
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46. [Radiological diagnosis of spondylitis]

Author

T, Okuyama, H, Suzuki, I, Kuwabara, K, Umehara, S, Nakamoto, and S, Suzuki

Subjects
Adult, Male, Spinal Neoplasms, Adolescent, Middle Aged, Diagnosis, Differential, Child, Preschool, Humans, Female, Tuberculosis, Spinal, Child, Radionuclide Imaging, Tomography, X-Ray Computed, Aged, Spondylitis
Published
1983

48. Detection of antigenic substances in patients with IgA nephropathy

Author

Y, Tomino, H, Sakai, M, Miura, Y, Nomoto, K, Umehara, and K, Hashimoto

Subjects
Cell Extracts, Chlorocebus aethiops, Palatine Tonsil, Animals, Humans, Glomerulonephritis, IGA, Binding Sites, Antibody, Antigens, Cell Line, Immunoglobulin A
Published
1984

49. Trial of isolation of a virus from sera of patients with Kawasaki disease

Author

K, Umehara, H, Kuno-Sakai, H, Iwasaki, R, Takesue, N, Hoshi, T, Furukawa, K, Ikeda, Y, Yabe, M, Kimura, and W C, Leung

Subjects
Child, Preschool, Viruses, Humans, Infant, Viremia, Mucocutaneous Lymph Node Syndrome
Abstract

We tried to isolate pathogenic viruses from specimens of patients with Kawasaki disease. Blood clots and sera, spinal fluid, throat swabs, stool and urine from 24 patients with Kawasaki disease were studied. The specimens were inoculated into HEL cells and Vero cells. The cells were observed for one month, but no cytopathic effect (CPE) occurred. Blind passage was performed, but no degeneration of the second series of cells was observed. Fluorescent antibody indirect methods to determine viral antigens in cells inoculated with patients' specimens was also negative.

Published
1986

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