1. KRIT1 as a possible new player in melanoma aggressiveness
- Author
-
Federica Finetti, Jasmine Ercoli, Lorenza Trabalzini, Giuseppe Valacchi, Giuseppe Belmonte, Clelia Miracco, and Brittany Woodby
- Subjects
0301 basic medicine ,Scaffold protein ,Adult ,Male ,Cell signaling ,Inflammation ,KRIT1 ,Melanoma ,N-cadherin ,Tumor suppressor ,β-catenin ,Biophysics ,Down-Regulation ,Biochemistry ,NO ,03 medical and health sciences ,Cell Movement ,Cell Line, Tumor ,Medicine ,Humans ,Molecular Biology ,KRIT1 Protein ,beta Catenin ,Aged ,Cell Proliferation ,Aged, 80 and over ,Cell Nucleus ,030102 biochemistry & molecular biology ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,030104 developmental biology ,Gene Knockdown Techniques ,Cutaneous melanoma ,Cancer research ,Melanocytes ,Female ,KRIT1, Melanoma, Tumor suppressor, N-cadherin, Inflammation, β-catenin ,Skin cancer ,medicine.symptom ,Signal transduction ,business - Abstract
Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective role against inflammation and oxidative stress. KRIT1 has been studied as a regulator of endothelial cell functions and represents a determinant in the pathogenesis of Cerebral Cavernous Malformation (CCM), a cerebrovascular disease characterized by the formation of clusters of abnormally dilated and leaky blood capillaries, which predispose to seizures, neurological deficits and intracerebral hemorrhage. Although KRIT1 is ubiquitously expressed, few studies have described its involvement in pathologies other than CCM including cancer. Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic propensity. Despite the numerous efforts made to define the signaling pathways activated during melanoma progression, the molecular mechanisms at the basis of melanoma growth, phenotype plasticity and resistance to therapies are still under investigation.
- Published
- 2020