9 results on '"Katherine J Nash"'
Search Results
2. Lack of association between feline AB blood groups and retroviral status: a multicenter, multicountry study
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Eva Spada, Hyein Jung, Daniela Proverbio, Roberta Perego, Luciana Baggiani, Silvia Ciuti, Claire R Sharp, Katherine J Nash, Mark Westman, Philippa JP Lait, and Elizabeth B Davidow
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Leukemia Virus, Feline ,Immunodeficiency Virus, Feline ,Cat Diseases ,Feline Acquired Immunodeficiency Syndrome ,Leukemia, Feline ,Blood Group Antigens ,Cats ,Animals ,Humans ,Settore VET/05 - Malattie Infettive degli Animali Domestici ,Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria ,Small Animals ,Settore VET/08 - Clinica Medica Veterinaria ,Retrospective Studies ,Retroviridae Infections - Abstract
Objectives The relationship between blood group antigens and disease has been studied in humans. Blood types have been associated with both decreased and increased rates of various infections. In addition, blood group expression has been shown to vary with some cancers and gastrointestinal diseases. The objective of this study was to explore whether there is a relationship between blood type and retroviral infections in cats. Methods Case records from a veterinary research laboratory, veterinary teaching hospitals and veterinary blood banks were retrospectively searched for cats where both blood type and retroviral status (feline leukemia [FeLV], feline immunodeficiency virus [FIV] or both) were listed (part 1). In addition, a sample of 33 cats with confirmed FIV infection was genotyped to determine blood groups (part 2). Results In part 1, 709 cats were identified, 119 of which were positive for retroviral infection. Among all cases, 621 were type A (87.6%), 68 were type B (9.6%) and 20 were type AB (2.8%). There was no relationship between overall retroviral status (positive/negative) and blood type ( P = 0.43), between FeLV status and blood type ( P = 0.86) or between FIV status and blood type ( P = 0.94). There was no difference in the distribution of blood types between cats that were healthy and typed as possible blood donors vs sick cats that were typed prior to a possible transfusion ( P = 0.13). In part 2, of the 33 FIV-infected cats, all blood group genotypes were identified, although this test did not discriminate type A from type AB. Conclusions and relevance No relationship was identified between feline retroviral status and blood type in this study. The relationship between blood type and other disease states requires further study in veterinary patients.
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- 2022
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3. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS) Part 2: Prevention and monitoring
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Adesola Odunayo, Shauna L. Blois, Karen Humm, Claire R. Sharp, Elizabeth B. Davidow, Eva Spada, Lauren Harris, Isabelle Goy-Thollot, Sarah Musulin, Jenny Walton, John M. Thomason, K. Jane Wardrop, and Katherine J Nash
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Veterinary Medicine ,medicine.medical_specialty ,Consensus ,040301 veterinary sciences ,Population ,Specialty ,MEDLINE ,Cat Diseases ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Transfusion reaction ,medicine ,Animals ,Dog Diseases ,Intensive care medicine ,education ,Blood type ,education.field_of_study ,General Veterinary ,Transfusion Medicine ,business.industry ,Transfusion Reaction ,030208 emergency & critical care medicine ,Transfusion medicine ,04 agricultural and veterinary sciences ,Evidence-based medicine ,Veterinary hematology ,Practice Guidelines as Topic ,Cats ,business - Abstract
Objective To systematically review available evidence to develop guidelines for the prevention of transfusion reactions and monitoring of transfusion administration in dogs and cats.Design Evidence evaluation of the literature (identified through Medline searches through Pubmed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. Evidence was evaluated using PICO (Population, Intervention, Comparison, Outcome) questions generated for each reaction type. Evidence was categorized by level of evidence (LOE) and quality (Good, Fair, or Poor). Guidelines for prevention and monitoring were generated based on the synthesis of the evidence. Consensus on the final recommendations and a proposed transfusion administration monitoring form was achieved through Delphi-style surveys. Draft recommendations and the monitoring form were made available through veterinary specialty listservs and comments were incorporated.Results Twenty-nine guidelines and a transfusion administration monitoring form were formulated from the evidence review with a high degree of consensusConclusions This systematic evidence evaluation process yielded recommended prevention and monitoring guidelines and a proposed transfusion administration form. However, significant knowledge gaps were identified, demonstrating the need for additional research in veterinary transfusion medicine.
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- 2021
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4. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) transfusion reaction small animal consensus statement (TRACS). Part 3: Diagnosis and treatment
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Elizabeth B. Davidow, Sarah Musulin, Katherine J Nash, Jenny Walton, Lauren Harris, Adesola Odunayo, Isabelle Goy-Thollot, K. Jane Wardrop, John M. Thomason, Karen Humm, Eva Spada, Shauna L. Blois, and Claire R. Sharp
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Veterinary Medicine ,medicine.medical_specialty ,040301 veterinary sciences ,Population ,Specialty ,MEDLINE ,Cat Diseases ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Transfusion reaction ,Small animal ,medicine ,Animals ,Dog Diseases ,Intensive care medicine ,education ,education.field_of_study ,General Veterinary ,Transfusion Medicine ,business.industry ,Transfusion Reaction ,030208 emergency & critical care medicine ,Transfusion medicine ,04 agricultural and veterinary sciences ,Evidence-based medicine ,Veterinary hematology ,Practice Guidelines as Topic ,Cats ,business - Abstract
Objective To systematically review available evidence to develop guidelines for diagnosis and treatment of transfusion-associated reactions in dogs and cats.Design Standardized and systemic evaluation of the literature (identified through Medline via PubMed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. The available evidence was evaluated using PICO (Population, Intervention, Comparison, Outcome) questions generated for each reaction type. The evidence was categorized by level of evidence (LOE) and quality (Good, Fair, or Poor). Guidelines, diagnostic, and treatment algorithms were generated based on the evaluation of the evidence. Consensus on the final guidelines was achieved through Delphi-style surveys. Draft recommendations were disseminated through veterinary specialty listservs for review and comments, which were evaluated and integrated prior to final publication.Results Medline via PubMed and Google Scholar databases were searched. There were 14 Population Intervention Comparison Outcome questions identified and corresponding worksheets were developed focusing on the diagnosis and treatment of transfusion-associated reactions in dogs and cats. Fourteen guidelines and four algorithms were developed with a high degree of consensus.Conclusions This systematic evidence evaluation process yielded recommended diagnostic and treatment algorithms for use in practice. However, significant knowledge gaps were identified, demonstrating the need for additional research in veterinary transfusion medicine.
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- 2021
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5. Review for 'Transient thrombocytopenia in a cat following G‐CSF treatment'
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null Katherine J. Nash
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- 2021
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6. Review for 'A case of canine Salmonella spp . osteomyelitis with secondary fracture following dog bite'
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Katherine J. Nash
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Salmonella ,business.industry ,Fracture (mineralogy) ,Osteomyelitis ,medicine ,Dentistry ,business ,medicine.disease ,medicine.disease_cause ,Dog bite - Published
- 2021
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7. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs
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Claire R. Sharp, Sarah Musulin, Jenny Walton, Karen Humm, Elizabeth B. Davidow, Katherine J Nash, Lauren Harris, Adesola Odunayo, Eva Spada, K. Jane Wardrop, Isabelle Goy-Thollot, John M. Thomason, and Shauna L. Blois
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Veterinary Medicine ,medicine.medical_specialty ,Consensus ,General Veterinary ,business.industry ,Transfusion Medicine ,Specialty ,Transfusion Reaction ,Transfusion medicine ,Cat Diseases ,Dogs ,Transfusion reaction ,Small animal ,Veterinary hematology ,Practice Guidelines as Topic ,medicine ,Cats ,Animals ,Dog Diseases ,Intensive care medicine ,business - Abstract
Objective To use a systematic, evidence-based consensus process to develop definitions for transfusion reactions in dogs and cats.Design Evidence evaluation of the literature was carried out for identified transfusion reaction types in dogs and cats. Reaction definitions were generated based on synthesis of human and veterinary literature. Consensus on the definitions was achieved through Delphi-style surveys. Draft recommendations were made available through industry specialty listservs and comments were incorporated.Results Definitions with imputability criteria were developed for 14 types of transfusion reactions.Conclusions The evidence review and consensus process resulted in definitions that can be used to facilitate future veterinary transfusion reaction research.
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- 2020
8. In vitro effect of blood cell counts on multiple-electrode impedance aggregometry in dogs
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Pete W. Christopherson, Katherine J Nash, Elizabeth Spangler, and Lenore M. Bacek
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Blood Platelets ,Male ,Platelet Aggregation ,Platelet Function Tests ,040301 veterinary sciences ,Reference range ,030204 cardiovascular system & hematology ,0403 veterinary science ,Andrology ,Blood cell ,03 medical and health sciences ,chemistry.chemical_compound ,Leukocyte Count ,0302 clinical medicine ,Dogs ,In vivo ,Reference Values ,hemic and lymphatic diseases ,Sodium citrate ,medicine ,Electric Impedance ,Animals ,Platelet ,Electrodes ,Leukopenia ,General Veterinary ,Platelet Count ,Area under the curve ,04 agricultural and veterinary sciences ,General Medicine ,In vitro ,Blood Cell Count ,medicine.anatomical_structure ,chemistry ,Area Under Curve ,Female ,medicine.symptom - Abstract
OBJECTIVE To assess the effect of decreased platelet and WBC counts on platelet aggregation as measured by a multiple-electrode impedance aggregometer in dogs. ANIMALS 24 healthy dogs. PROCEDURES From each dog, 9 mL of blood was collected into a 10-mL syringe that contained 1 mL of 4% sodium citrate solution to yield a 10-mL sample with a 1:9 citrate-to-blood ratio. Each sample was then divided into unmanipulated and manipulated aliquots with progressively depleted buffy-coat fractions such that 2 to 3 blood samples were evaluated per dog. The Hct for manipulated aliquots was adjusted with autologous plasma so that it was within 2% of the Hct for the unmanipulated aliquot for each dog. All samples were analyzed in duplicate with a multiple-electrode impedance aggregometer following the addition of ADP as a platelet agonist. The respective effects of platelet count, plateletcrit, Hct, and WBC count on platelet aggregation area under the curve (AUC), aggregation, and velocity were analyzed with linear mixed models. RESULTS WBC count was positively associated with platelet AUC, aggregation, and velocity; blood samples with leukopenia had a lower AUC, aggregation, and velocity than samples with WBC counts within the reference range. Platelet count, plateletcrit, and Hct did not have an independent effect on AUC, aggregation, or velocity. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that WBC count was positively associated with platelet aggregation when ADP was used to activate canine blood samples for impedance aggregometry. That finding may be clinically relevant and needs to be confirmed by in vivo studies.
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- 2017
9. A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs
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Georgina B. F. Hall, Rachael Birkbeck, Benjamin M. Brainard, Fernanda Camacho, Elizabeth B. Davidow, Dana N. LeVine, Andrew Mackin, Taylor Moss, Katherine J. Nash, Giacomo Stanzani, Daria Starybrat, David Q. Stoye, Carolyn Tai, John Thomason, Julie M. Walker, K. Jane Wardrop, Helen Wilson, Virginie A. Wurlod, and Karen Humm
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AHTR ,dog ,FNHTR ,leukoreduction ,storage lesion ,TACO ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Reported incidence of blood transfusion reactions (TR) varies greatly. Objective To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors associated with TRs. Animals Dogs (n = 858) administered allogenic blood products (n = 1542) between March and November 2022. Methods Prospective, multicenter surveillance study occurring in referral hospitals in the United States, United Kingdom, and Australia recording TRs in dogs administered blood products as defined by the consensus guidelines published by The Association of Veterinary Hematology and Transfusion Medicine in 2021. Results The incidence of acute TR was 8.9% (95% CI 7.0‐11.1) for packed red blood cells (pRBCs) and 4.5% (95% CI 2.9‐6.6) for plasma products. The most frequently reported TRs were febrile nonhemolytic TRs (FNHTR; 4%, 95% CI 2.8‐5.5) when administering pRBCs and allergic TRs (3.2%, 95% CI 1.80‐5.10) when administering plasma products. A higher dose of pRBC (adjusted odds ratio [aOR] 1.04 [95% CI 1.00‐1.08]) was associated with a higher odds of TR. Administration of pRBCs stored for longer than 28 days was associated with higher odds of FNHTR (aOR 4.10 [95% CI 1.58‐10.65]) and acute hemolytic TR (AHTR; OR 15.2 [95% CI 3.35‐68.70]) when compared with pRBCs stored for 14 days or fewer. Leukoreduction of pRBC was not associated with lower odds of developing a TR (OR 1.47 [95% CI 0.89‐2.42]). Conclusions and Clinical Importance Clinicians should be mindful of the age and dose of pRBC prescribed to dogs.
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- 2024
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