143 results on '"Kemal, O."'
Search Results
2. Seismic Soil Liquefaction Triggering Assessment of Gravelly Soil Case Histories
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Sahin, Arda, primary and Cetin, Kemal O., additional
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- 2024
- Full Text
- View/download PDF
3. Gravelly Liquefaction Case Histories after 2008 Wenchuan-China Earthquake Mw = 7.9.
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Sahin, Arda and Cetin, Kemal O.
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- 2023
- Full Text
- View/download PDF
4. Special issue on the Versatile Test Reactor (VTR)
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Pasamehmetoglu, Kemal O., primary and Ougouag, Abderrafi M., additional
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- 2022
- Full Text
- View/download PDF
5. Assessment of possible cycle lengths for fully encapsulated microstructure fueled light water reactor concepts
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Sen, R. Sonat, Pope, Michael A., Ougouag, Abderrafi M., and Pasamehmetoglu, Kemal O.
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- 2013
- Full Text
- View/download PDF
6. Special issue on the Versatile Test Reactor (VTR)
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Kemal O. Pasamehmetoglu and Abderrafi M. Ougouag
- Subjects
Nuclear Energy and Engineering - Published
- 2022
7. An Updated Shear Wave Velocity-Based Seismic Soil Liquefaction Triggering Database
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Makbule Ilgac, Robert E. Kayen, Clinton Wood, and Kemal O. Cetin
- Published
- 2022
8. Updated SPT-Based Seismic Soil Liquefaction Triggering Global Database
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Makbule Ilgac, Kemal O. Cetin, and Robert. E. Kayen
- Published
- 2022
9. An Updated Shear Wave Velocity-Based Seismic Soil Liquefaction Triggering Database
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Ilgac, Makbule, primary, Kayen, Robert E., additional, Wood, Clinton, additional, and Cetin, Kemal O., additional
- Published
- 2022
- Full Text
- View/download PDF
10. Updated SPT-Based Seismic Soil Liquefaction Triggering Global Database
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Ilgac, Makbule, primary, Cetin, Kemal O., additional, and Kayen, Robert. E., additional
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- 2022
- Full Text
- View/download PDF
11. LDRD Strategic R&D Fund – Fiscal Year 2018 Research Priorities
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Pillai, Rekha, primary, Gianotto, Anita, additional, Hartenstein, Steven, additional, Wagner, John, additional, Schoonen, David, additional, Meyer, Mitch, additional, Beierschmitt, Kelly J., additional, Pasamehmetoglu, Kemal O., additional, Hagood, Michael, additional, Tudor, Zachary, additional, Crone, Ronald A., additional, and O'Kelly, Sean, additional
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- 2017
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- View/download PDF
12. THE RELATIONSHIP BETWEEN VIABILITY AND ENGRAFTMENT IN AUTOLOGOUS TRANSPLANTATION OF PERIPHERAL BLOOD STEM CELLS: PH-AB174
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Salim, O., Toptas, T., Ekinci, D., Gocer, M., Yucel, Kemal O., Salim, Kivrak D., and Undar, L.
- Published
- 2014
13. An amino acid deletion inSZT2 in a family with non-syndromic intellectual disability.
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Michelle Falcone, Kemal O Yariz, David B Ross, Joseph Foster, Ibis Menendez, and Mustafa Tekin
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Medicine ,Science - Abstract
Autosomal recessive intellectual disability (ID) is characterized by extensive genetic heterogeneity. Recently, three mutations in SZT2 were reported in two unrelated children with unexplained infantile epileptic encephalopathy with severe ID. Here we report a European American family with three children having non-syndromic mild or moderate ID without seizures. Whole-exome sequencing of three affected siblings revealed a three base pair deletion (c.4202_4204delTTC) located in a 19 mb autozygous region on chromosome 1, leading to an amino acid deletion (p.Phe1401del) in SZT2. All three children were homozygous for the deletion and their parents were heterozygous as expected in autosomal recessive inheritance. SZT2 is highly expressed in neuronal tissues and regulates seizure threshold and neuronal excitation in mice. We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate ID without seizures.
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- 2013
- Full Text
- View/download PDF
14. Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy
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Ramser, Juliane, Ahearn, Mary Ellen, Lenski, Claus, Yariz, Kemal O., Hellebrand, Heide, Rhein, Michael von, Clark, Robin D., Schmutzler, Rita K., Lichtner, Peter, Hoffman, Eric P., Meindl, Alfons, and Baumbach-Reardon, Lisa
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Spinal muscular atrophy -- Genetic aspects ,Gene mutations -- Health aspects ,Gene mutations -- Research ,Nervous system -- Degeneration ,Nervous system -- Genetic aspects ,Biological sciences - Abstract
Large-scale mutation analysis is performed in genes located between markers DXS8080 and DXS7132 to identify the X-linked infantile spinal muscular atrophy (XL-SMA). It is indicated that XL-SMA is part of a growing list of neurodegenerative disorders associated with defects in the ubiquitin-proteasome pathway and that synonymous C ->T transitions have the potential to affect gene expression.
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- 2008
15. Occupational exposure to blood and body fluids among health care workers in Ankara, Turkey
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Azap, Alpay, Ergönül, Önder, Memikoğlu, Kemal O., Yeşilkaya, Aypegül, Altunsoy, Adalet, Bozkurt, Gülden-Yýlmaz, and Tekeli, Emil
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- 2005
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16. Human Papillomavirus in Laryngeal Cancer in Northern Region of Turkey
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Kemal, Y., primary, Kemal, O., additional, Kefeli, M., additional, Gün, S., additional, Bel, A., additional, Sahin, N., additional, Atmaca, S., additional, Koyuncu, M., additional, and Yucel, I., additional
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- 2018
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17. Wound and soft tissue infections of Serratia marcescens in patients receiving wound care: A health care–associated outbreak
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Us, Ebru, Kutlu, Huseyin H., Tekeli, Alper, Ocal, Duygu, Cirpan, Sevilay, and Memikoglu, Kemal O.
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- 2017
- Full Text
- View/download PDF
18. LDRD Strategic R&D Fund – Fiscal Year 2018 Research Priorities
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Kemal O. Pasamehmetoglu, Rekha S Pillai, Zachary Tudor, Michael Hagood, Anita K. Gianotto, David Schoonen, Sean O'Kelly, John Wagner, Ronald A. Crone, Kelly J. Beierschmitt, Steven Hartenstein, and Mitch Meyer
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Finance ,Fiscal year ,business.industry ,Political science ,business - Published
- 2017
19. Isolated sphenochoanal polyp: report of three cases
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Çeçen A, Kemal O, Atmaca S, ESRA KAVAZ, and Ondokuz Mayıs Üniversitesi
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surgical procedures, operative ,nasal endoscopy ,otorhinolaryngologic diseases ,excision ,magnetic resonance imaging ,Case Report ,nasal obstruction ,computed tomography ,pathological conditions, signs and symptoms ,Sphenochoanal polyp ,neoplasms ,digestive system diseases - Abstract
KAVAZ, ESRA/0000-0002-6297-6012 WOS: 000450408800008 PubMed: 30479479 Background: Choanal polyps constitute 3-6 % of all nasal polyps and are lesions which usually originate from the mucosa of the maxillary sinus and have a solitary growth pattern. Polyps originating from the sphenoid sinus are rarely seen and are known as sphenochoanal polyps. Surgical treatment of the sphenochoanal polyps is its complete excision together with the pedicle and the portion inside the sphenoid sinus. Cases report: We report the cases of three patients who were referred to the ENT outpatient department for a persistent unilateral nasal obstruction that was resistant to medical treatment. After their clinical and endoscopic examination and imaging evaluation, these patients underwent endoscopic excision of the sphenochoanal polyps which in histopathology were proven to be inflammatory polyps. Conclusion: Although rarely seen sphenochoanal polyps must be kept in mind in the differential diagnosis of unilateral sphenoid sinus and posterior nasal cavity masses.
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- 2017
20. Assessment of possible cycle lengths for fully encapsulated microstructure fueled light water reactor concepts
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Michael A. Pope, R. Sonat Sen, Abderrafi M. Ougouag, and Kemal O. Pasamehmetoglu
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Nuclear and High Energy Physics ,Engineering ,Engineering drawing ,Fissile material ,business.industry ,Mechanical Engineering ,Nuclear engineering ,Uranium dioxide ,Fluid mechanics ,Enriched uranium ,Atomic packing factor ,Thermal hydraulics ,Surface coating ,chemistry.chemical_compound ,Nuclear Energy and Engineering ,chemistry ,General Materials Science ,Light-water reactor ,Safety, Risk, Reliability and Quality ,business ,Waste Management and Disposal - Abstract
The use of TRISO-particle-based dispersion fuel within SiC matrix and cladding materials has the potential to allow the design of extremely safe LWRs with failure-proof fuel. This paper examines the feasibility of LWR-like cycle length for such fuel with the imposed constraint of strictly retaining the original geometry of the fuel pins and assemblies. The motivation for retaining the original geometry is to provide the ability to incorporate the fuel “as-is” into existing LWRs while retaining their thermal–hydraulic characteristics. Another mandatory constraint is use of low enriched uranium (at or below 20 w/o). The feasibility of using this fuel is assessed by looking at two factors: cycle lengths and fuel material failure rates. Other considerations (e.g., safety parameters such as reactivity coefficients, feedback, etc.) were not considered at this stage of the study. The study includes the examination of increases in the TRISO kernel sizes without changing the thickness of any of the coating layers. In addition, cases where the buffer layer thickness is allowed to vary are also considered. The study shows that a naive use of UO 2 (even up to 20 w/o enrichment) results in cycle lengths too short to be practical for existing LWR designs and operational demands. Increasing fissile inventory within the fuel compacts shows that acceptable cycle lengths can be achieved. The increase of fissile inventory can be accomplished through multiple means, including higher particle packing fraction, higher enrichment, larger fuel kernel sizes, and the use of higher density fuels (that contain a higher number of U atoms per unit volume). In this study, starting with the recognized highest packing fraction practically achievable (44%), combinations of the other means have been evaluated. The models demonstrate cycle lengths comparable to those of ordinary LWRs. As expected, TRISO particles with extremely large kernels are shown to fail under all considered scenarios. In contrast, the designs that do not depart too drastically from those of the nominal NGNP HTR fuel TRISO particles are shown to perform satisfactorily and display a high rates of survival under all considered scenarios.
- Published
- 2013
21. Randomized Phase II Trial of Letrozole plus Anti-MUC1 Antibody AS1402 in Hormone Receptor–Positive Locally Advanced or Metastatic Breast Cancer
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Kemal O. Yariz, Albert Chau, David R. Jones, Nuhad K. Ibrahim, Alexei Manikhas, Yaroslav Shparyk, James L. Murray, Fredrik Erlandsson, I. Bondarenko, Gary Acton, Mark D. Pegram, Volodymyr Komisarenko, Vladimir Semiglazov, Shai Senderovich, and Anna Alyasova
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Oncology ,Cancer Research ,medicine.medical_specialty ,Estrogen receptor ,Breast Neoplasms ,Antibodies, Monoclonal, Humanized ,Drug Administration Schedule ,Breast cancer ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,Nitriles ,medicine ,Clinical endpoint ,Humans ,Neoplasm Metastasis ,Aromatase ,Immunoglobulin Allotypes ,Neoplasm Staging ,biology ,Aromatase Inhibitors ,business.industry ,Letrozole ,Mucin-1 ,Receptors, IgG ,Antibodies, Monoclonal ,Cancer ,Middle Aged ,Triazoles ,medicine.disease ,Metastatic breast cancer ,Endocrinology ,Receptors, Estrogen ,Monoclonal ,biology.protein ,Female ,Receptors, Progesterone ,business ,medicine.drug - Abstract
Purpose: AS1402 is a humanized immunoglobulin G1 antibody that targets the aberrantly glycosylated antigen MUC1, which is overexpressed in 90% of breast tumors and contributes to estrogen-mediated growth and survival of breast cancer cells in vitro by modulating estrogen receptor (ER) activity. Aromatase inhibitors have been reported to enhance antibody-dependent cell-mediated cytotoxicity elicited by antibodies in vitro. We compared the outcomes of patients with breast cancer treated with letrozole with or without AS1402. Experimental Design: The study population included 110 patients with locally advanced or metastatic hormone receptor–positive breast cancer randomized to receive 2.5 mg letrozole only once daily or with a weekly 9 mg/kg AS1402 infusion. The primary endpoint was overall response rate. Secondary endpoints included progression-free survival, time to progression, and safety. AS1402 exposure and influence of allotypes of FcγRIIIa, FcγRIIa, and MUC1 were evaluated. Results: The study was stopped early because of a trend toward worse response rates and a higher rate of early disease progression in the AS1402 + letrozole arm. Final analysis revealed no significant difference in efficacy between the study arms. Evaluated gene polymorphisms did not define patient subgroups with improved outcomes. Addition of AS1402 to letrozole was associated with manageable toxicity. Conclusions: Because adding AS1402 to letrozole did not improve outcomes compared with letrozole only, blocking ER may be a better strategy for harnessing MUC1 modulation of the ER to a clinical advantage. FcγRIIIa, FcγRIIa, and MUC1 allotype did not predict outcome for patients treated with letrozole with or without AS1402. Clin Cancer Res; 17(21); 6822–30. ©2011 AACR.
- Published
- 2011
22. Cardiomyopathy with alopecia and palmoplantar keratoderma (CAPK) is caused by a JUP mutation
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T. Sayin, Aylin Okçu Heper, Kemal O. Yariz, H. Erken, C.T. Kaya, Duygu Duman, and Mustafa Tekin
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Adult ,Male ,Heterozygote ,Pathology ,medicine.medical_specialty ,Hyperkeratosis ,Mutation, Missense ,Cardiomyopathy ,Plakoglobin ,Dermatology ,medicine.disease_cause ,Germline mutation ,Keratoderma, Palmoplantar ,Desmosome ,Humans ,Medicine ,Keratoderma ,Genetics ,Mutation ,business.industry ,Alopecia ,Middle Aged ,medicine.disease ,Palmoplantar keratoderma ,medicine.anatomical_structure ,Desmoplakins ,gamma Catenin ,Cardiomyopathies ,business - Abstract
Inherited desmosomal cardiocutaneous syndromes are characterized by the quartet of woolly hair, palmoplantar keratoderma (PPK), skin fragility and cardiac abnormalities, which are caused by mutations in genes coding for desmosomal proteins. We describe a previously unrecognized autosomal recessive syndrome in a family with arrhythmogenic right ventricular cardiomyopathy associated with alopecia and PPK (named CAPK). Genetic investigation of the family led us to find a homozygous disease-causing mutation, p.R265H, in JUP which encodes plakoglobin, a well-described member of the desmosome complex. This study expands the clinical spectrum of disorders associated with germline mutations affecting desmosomal proteins by describing a novel phenotype.
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- 2011
23. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss
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Adil Cinar Akkaynak, Hatice Akay, Mary Claire King, Kemal O. Yariz, Tom Walsh, Mustafa Tekin, and Duygu Duman
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Male ,Genotype ,Turkey ,Hearing loss ,Genes, Recessive ,Consanguinity ,Biology ,Polymorphism, Single Nucleotide ,Article ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,Hearing Loss ,Genetics (clinical) ,Truncating mutation ,Genetic heterogeneity ,Homozygote ,Intracellular Signaling Peptides and Proteins ,Phenotype ,Mutation ,Mutation (genetic algorithm) ,Female ,Allelic heterogeneity ,medicine.symptom - Abstract
Yariz KO, Walsh T, Akay H, Duman D, Akkaynak AC, King M-C, Tekin M. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Hereditary deafness is a genetically heterogeneous phenotype for which more than 100 genomic loci have been identified thus far. By analysis of a consanguineous Palestinian family, GPSM2 was recently discovered to be the cause of autosomal recessive non-syndromic hearing loss DFNB82. Here, we report a second truncating mutation, GPSM2 p.Q562X, identified via autozygosity mapping in a consanguineous Turkish family. This report provides evidence for allelic heterogeneity of GPSM2 and confirms its causative role for non-syndromic deafness.
- Published
- 2011
24. Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy
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Alfons Meindl, Rita K. Schmutzler, Michael von Rhein, Eric P. Hoffman, Kemal O. Yariz, Lisa Baumbach-Reardon, Peter Lichtner, Robin D. Clark, Juliane Ramser, Claus Lenski, Heide Hellebrand, and Mary Ellen Ahearn
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Male ,Silent mutation ,DNA Mutational Analysis ,Mutation, Missense ,Ubiquitin-Activating Enzymes ,Spinal Muscular Atrophies of Childhood ,Biology ,Exon ,Genes, X-Linked ,Report ,Genetics ,medicine ,Humans ,Point Mutation ,Missense mutation ,Genetics(clinical) ,Genetics (clinical) ,X chromosome ,Arthrogryposis ,Infant, Newborn ,Infant ,UBA1 ,Hypotonia ,Pedigree ,Female ,medicine.symptom ,Synonymous substitution - Abstract
X-linked infantile spinal muscular atrophy (XL-SMA) is an X-linked disorder presenting with the clinical features hypotonia, areflexia, and multiple congenital contractures (arthrogryposis) associated with loss of anterior horn cells and infantile death. To identify the XL-SMA disease gene, we performed large-scale mutation analysis in genes located between markers DXS8080 and DXS7132 (Xp11.3-Xq11.1). This resulted in detection of three rare novel variants in exon 15 of UBE1 that segregate with disease: two missense mutations (c.1617 G--T, p.Met539Ile; c.1639 A--G, p.Ser547Gly) present each in one XL-SMA family, and one synonymous C--T substitution (c.1731 C--T, p.Asn577Asn) identified in another three unrelated families. Absence of the missense mutations was demonstrated for 3550 and absence of the synonymous mutation was shown in 7914 control X chromosomes; therefore, these results yielded statistical significant evidence for the association of the synonymous substitution and the two missense mutations with XL-SMA (p = 2.416 x 10(-10), p = 0.001815). We also demonstrated that the synonymous C--T substitution leads to significant reduction of UBE1 expression and alters the methylation pattern of exon 15, implying a plausible role of this DNA element in developmental UBE1 expression in humans. Our observations indicate first that XL-SMA is part of a growing list of neurodegenerative disorders associated with defects in the ubiquitin-proteasome pathway and second that synonymous C--T transitions might have the potential to affect gene expression.
- Published
- 2008
25. An approach to fuel development and qualification
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Kemal O. Pasamehmetoglu, Steven L. Hayes, Douglas C. Crawford, David A. Petti, Douglas L. Porter, and Mitchell K. Meyer
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Nuclear and High Energy Physics ,Engineering ,Nuclear fuel ,GeneralLiterature_INTRODUCTORYANDSURVEY ,business.industry ,Reference design ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,Plan (drawing) ,Take over ,Energy technology ,Manufacturing engineering ,Development (topology) ,Nuclear Energy and Engineering ,Material selection ,General Materials Science ,Safety case ,business - Abstract
Some of the rationale for nuclear energy technology development in the US has been lost or forgotten over the past two decades with the lack of a focused reactor development program. But the emergence of new R&D programs points to a need to understand how best to plan for a long-term fuel development program. The rationale for such a program is not easily found in the literature, so the authors have suggested a structure and rationale. The approach is described as four phases, with emphasis on selecting a reference fuel concept, evaluating and improving the fuel to develop a fuel specification for a reference design, obtaining data to support a licensing safety case for the fuel, and final qualification of the fuel for a specific application. Because a fuel program requires long-lead-time irradiation testing, bringing a fuel design from the initial concept through licensing might take over 20 years.
- Published
- 2007
26. Effects of heterozygosity for the E180 splice mutation causing growth hormone receptor deficiency in Ecuador on IGF-I, IGFBP-3, and stature
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Kemal O. Yariz, Jaime Guevara-Aguirre, Jonathan J. Shuster, Lisa Baumbach, Arlan L. Rosenbloom, Marco Guevara-Aguirre, and Jeanette Saavedra
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Adult ,Male ,Heterozygote ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Population ,Dwarfism ,Context (language use) ,Growth hormone receptor ,Biology ,Loss of heterozygosity ,Endocrinology ,Internal medicine ,Genotype ,medicine ,Laron syndrome ,Humans ,splice ,Insulin-Like Growth Factor I ,Child ,education ,Genotyping ,Aged ,Aged, 80 and over ,education.field_of_study ,Infant ,Receptors, Somatotropin ,Middle Aged ,medicine.disease ,Body Height ,Laron Syndrome ,Pedigree ,Alternative Splicing ,Insulin-Like Growth Factor Binding Protein 3 ,Child, Preschool ,Mutation ,Female ,Ecuador ,hormones, hormone substitutes, and hormone antagonists - Abstract
Context & objective: The Ecuadorian GH receptor deficiency (GHRD)/Laron syndrome population is the only large cohort with a single GHR mutation (E180 splice), permitting identification of numerous carrier and noncarrier first-degree relatives, to ascertain effects of heterozygosity on GH-dependent IGF-I and IGFBP-3 concentrations and on growth. Design: First-degree relatives (n = 212) of GHRD patients had specimens taken for IGF-I, IGFBP-3, and GHR genotyping. Normal statured (n = 40) and short statured (n = 40) unrelated controls had measurement of IGF-I, IGFBP-3, and stature. Results: There were no significant differences between heterozygous and homozygous normal relatives in IGF-I or IGFBP-3 standard deviation scores (SDS). Heterozygous relatives had lower mean height SDS than did homozygous normals, but with extensive overlap between genotype groups in both child and adult relatives. Height SDS in general did not relate to IGF-I or IGFBP-3 concentrations. Conclusions: GH-dependent IGF-I and IGFBP-3 secretion is not affected by heterozygosity for the E180 splice mutation that causes GHRD/Laron syndrome in the Ecuadorian population. Heterozygosity is associated with reduction in mean statural SDS, but this is not sufficient to be clinically important and not mediated through measurable differences in circulating IGF-I or IGFBP-3 related to genotype. 2007 Elsevier Ltd. All rights reserved.
- Published
- 2007
27. X-linked infantile spinal muscular atrophy: Clinical definition and molecular mapping
- Author
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Devin Dressman, Kemal O. Yariz, Brunhilde Wirth, Francesc Palau, Hugo Basterrecha, Mary Ellen Ahearn, Francisco Martínez, Eric P. Hoffman, Alfons Meindl, Lisa Baumbach-Reardon, M. Michael Barmada, and Robin D. Clark
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Genetic Linkage ,Single-nucleotide polymorphism ,Locus (genetics) ,Spinal Muscular Atrophies of Childhood ,Genetic linkage ,Microsatellite Repeat ,medicine ,Humans ,SNP ,Family ,Genetics (clinical) ,Arthrogryposis ,Genetics ,Chromosomes, Human, X ,business.industry ,Infant, Newborn ,Chromosome Mapping ,Infant ,DNA ,Hypotonia ,Pedigree ,Female ,medicine.symptom ,Candidate Disease Gene ,business ,Microsatellite Repeats - Abstract
Purpose: X-linked infantile spinal-muscular atrophy (XL-SMA) is a rare disorder, which presents with the clinical characteristics of hypotonia, areflexia, and multiple congenital contractures (arthrogryposis) associated with loss of anterior horn cells and death in infancy. We have previously reported a single family with XL-SMA that mapped to Xp11.3-q11.2. Here we report further clinical description of XL-SMA plus an additional seven unrelated (XL-SMA) families from North America and Europe that show linkage data consistent with the same region. Methods: We first investigated linkage to the candidate disease gene region using microsatellite repeat markers. We further saturated the candidate disease gene region using polymorphic microsatellite repeat markers and single nucleotide polymorphisms in an effort to narrow the critical region. Two-point and multipoint linkage analysis was performed using the Allegro software package. Results: Linkage analysis of all XL-SMA families displayed linkage consistent with the original XL-SMA region. Conclusion: The addition of new families and new markers has narrowed the disease gene interval for a XL-SMA locus between SNP FLJ22843 near marker DXS 8080 and SNP ARHGEF9 which is near DXS7132 (Xp11.3-Xq11.1).
- Published
- 2007
28. A homozygous SIX6 mutation is associated with optic disc anomalies and macular atrophy and reduces retinal ganglion cell differentiation
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Elif Funda Sener, Hatice Akay, X. Jin, Kemal O. Yariz, Yildirim Bayezit Sakalar, Amjad Farooq, M.N. Özbek, Jeffrey L. Goldberg, Jonathan Hertz, and Mustafa Tekin
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Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,Adolescent ,Biology ,Macular Degeneration ,Text mining ,Ophthalmology ,Optic Nerve Diseases ,Genetics ,medicine ,Humans ,Child ,Genetics (clinical) ,Homeodomain Proteins ,business.industry ,Homozygote ,Macular atrophy ,Cell Differentiation ,medicine.anatomical_structure ,Retinal ganglion cell ,Child, Preschool ,Mutation ,Mutation (genetic algorithm) ,Trans-Activators ,Female ,Atrophy ,business ,Optic disc - Published
- 2015
29. Inert matrix fuel neutronic, thermal-hydraulic, and transient behavior in a light water reactor
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Kemal O. Pasamehmetoglu, W.J. Carmack, Michael Todosow, and Mitch Meyer
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Inert ,Nuclear and High Energy Physics ,Fissile material ,Nuclear fuel ,Chemistry ,Nuclear engineering ,Nuclear reactor ,Spent nuclear fuel ,law.invention ,Nuclear Energy and Engineering ,law ,General Materials Science ,Light-water reactor ,MOX fuel ,Transuranium element ,Nuclear chemistry - Abstract
Currently, commercial power reactors in the United States operate on a once-through or open cycle, with the spent nuclear fuel eventually destined for long-term storage in a geologic repository. Since the fissile and transuranic (TRU) elements in the spent nuclear fuel present a proliferation risk, limit the repository capacity, and are the major contributors to the long-term toxicity and dose from the repository, methods and systems are needed to reduce the amount of TRU that will eventually require long-term storage. An option to achieve a reduction in the amount, and modify the isotopic composition of TRU requiring geological disposal is ‘burning’ the TRU in commercial light water reactors (LWRs) and/or fast reactors. Fuel forms under consideration for TRU destruction in light water reactors (LWRs) include mixed-oxide (MOX), advanced mixed-oxide, and inert matrix fuels. Fertile-free inert matrix fuel (IMF) has been proposed for use in many forms and studied by several researchers. IMF offers several advantages relative to MOX, principally it provides a means for reducing the TRU in the fuel cycle by burning the fissile isotopes and transmuting the minor actinides while producing no new TRU elements from fertile isotopes. This paper will present and discuss the results of amore » four-bundle, neutronic, thermal-hydraulic, and transient analyses of proposed inert matrix materials in comparison with the results of similar analyses for reference UOX fuel bundles. The results of this work are to be used for screening purposes to identify the general feasibility of utilizing specific inert matrix fuel compositions in existing and future light water reactors. Compositions identified as feasible using the results of these analyses still require further detailed neutronic, thermal-hydraulic, and transient analysis study coupled with rigorous experimental testing and qualification.« less
- Published
- 2006
30. Idaho National Laboratory Mission Accomplishments
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James Herzog, Mark Henry, Kelly Estes, Steven Hartenstein, Kemal O. Pasamehmetoglu, Dan Ogden, and Anita K. Gianotto
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Idaho National Laboratory ,Engineering ,business.industry ,business ,Archaeology - Published
- 2014
31. Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations
- Author
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Suat Fitoz, Ibis Menéndez, Asli Subasioglu, Susan H. Blanton, Levent Sennaroglu, Kemal O. Yariz, Akeem O. Lasisi, Paola Montenegro, Germania Moreta, Guney Bademci, Armagan Incesulu, Rodrigo Vinueza, Mustafa Tekin, and Rosario Paredes
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Male ,Models, Molecular ,medicine.medical_specialty ,Biology ,Deafness ,Cohort Studies ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,Sequencing ,Genetics(clinical) ,Mutation detection ,Inner ear ,Gene ,Mutation Detection ,Genetics (clinical) ,X-linked deafness ,Cytogenetics ,Genetic Diseases, X-Linked ,Molecular Diagnosis ,Human genetics ,3. Good health ,Pedigree ,Protein Structure, Tertiary ,POU3F4 ,medicine.anatomical_structure ,Child, Preschool ,POU Domain Factors ,Female ,sense organs ,Research Article - Abstract
Background Mutations in the POU3F4 gene cause X-linked deafness type 3 (DFN3), which is characterized by inner ear anomalies. Methods Three Turkish, one Ecuadorian, and one Nigerian families were included based on either inner ear anomalies detected in probands or X-linked family histories. Exome sequencing and/or Sanger sequencing were performed in order to identify the causative DNA variants in these families. Results Four novel, c.707A>C (p.(Glu236Ala)), c.772delG (p.(Glu258ArgfsX30)), c.902C>T (p.(Pro301Leu)), c.987T>C (p.(Ile308Thr)), and one previously reported mutation c.346delG (p.(Ala116ProfsX26)) in POU3F4, were identified. All mutations identified are predicted to affect the POU-specific or POU homeo domains of the protein and co-segregated with deafness in all families. Conclusions Expanding the spectrum of POU3F4 mutations in different populations along with their associated phenotypes provides better understanding of their clinical importance and will be helpful in clinical evaluation and counseling of the affected individuals. Electronic supplementary material The online version of this article (doi:10.1186/s12881-015-0149-2) contains supplementary material, which is available to authorized users.
- Published
- 2014
32. The U.S. accelerator transmutation of waste program
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Gregory J. Van Tuyle, Deborah Bennett, Ning Li, Phillip Fink, James J. Laidler, Kimberly W. Thomas, Kemal O. Pasamehmetoglu, Denis Beller, G.P. Lawrence, and David L. Hill
- Subjects
Product (business) ,Physics ,Fiscal year ,Nuclear and High Energy Physics ,Engineering management ,Appropriation ,Nuclear transmutation ,Software deployment ,Working group ,Dispose pattern ,Instrumentation ,Spent nuclear fuel - Abstract
A national project to develop a future capability to separate actinides and long-lived fission products from spent fuel, to transmute them, and to dispose off the remaining waste in optimal waste forms has begun in the United States. This project is based on the Accelerator-driven Transmutation of Waste (ATW) program developed during the 1990s at Los Alamos National Laboratory, and has its technological roots in several technologies that have been developed by the multi-mission laboratories of the U.S. Department of Energy (DOE). In the Fiscal Year 1999 Energy and Water Appropriation Act, the U.S. Congress directed the DOE to study ATW and by the end of FY99 to prepare a “roadmap” for developing this technology. DOE convened a steering committee, assembled four technical working groups consisting of members from many national laboratories, and consulted with several individual international and national experts. The finished product, “A Roadmap for Developing ATW Technology – A Report to Congress,” recommends a five-year, $281 M, science-based, technical-risk-reduction program. This paper provides an overview of the U.S. Roadmap for developing ATW technology, the organization of the national ATW Project, the critical issues in subsystems and technological options, deployment scenarios, institutional challenges, and academic and international collaboration.
- Published
- 2001
33. Thermal-Hydraulic Design of the Accelerator Production of Tritium Tungsten Neutron Source
- Author
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Gordon Willcutt, Donald A. Siebe, Jay S. Elson, and Kemal O. Pasamehmetoglu
- Subjects
Nuclear and High Energy Physics ,Materials science ,Critical heat flux ,020209 energy ,Nuclear engineering ,Flow (psychology) ,Reynolds number ,02 engineering and technology ,Condensed Matter Physics ,Coolant ,Subcooling ,Nuclear physics ,Thermal hydraulics ,symbols.namesake ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Nuclear Energy and Engineering ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,Neutron source ,Nucleate boiling - Abstract
The thermal-hydraulic design of the accelerator production of tritium (APT) tungsten neutron source is presented. A carefully engineered thermal-hydraulic design is required to remove the deposited power effectively during normal operations and remove the decay power during plant shutdown and postulated accidents. For steady-state operations and operational and anticipated transients, the design criterion is to maintain single-phase flow conditions with a margin to onset of nucleate boiling. The margin is determined based on phenomenological and geometric uncertainties associated with the design. A large margin to thermal excursion limits, such as critical heat flux and onset of flow instability, also is maintained during normal operations. In general, a very robust thermal-hydraulic design can be accomplished using the traditional models and correlations available in the engineering literature. However, two issues require further attention: maintaining adequate flows in a parallel network of flow channels and minimizing the volume fraction of heavy water to maximize tritium production.The design uses ladderlike structures that contain clad tungsten cylinders in the rungs that have coolant supplied and removed by the vertical ladder rails. Because the power density drops in the beam direction, the thickness of the tungsten cylinders is increased with increasing beam penetration length. The coolingmore » requirement is determined using a conservative criterion where the minimum wall subcooling inside the rungs is at least 40 deg. C and the minimum Reynolds number is 6000. Initial flow distribution tests were conducted with a full-scale model of an APT ladder assembly based on a preliminary design. Flow distributions can be made more even by using a larger riser than downcomer and also by increasing the flow resistance across each rung. The calculations discussed assume nominal dimensions, even though the power deposition and removal use a conservative approach. The effect of manufacturing tolerances will be investigated in future research. Also, the applicability of the critical heat flux and onset of flow instability models to small coolant channels is being verified experimentally. Further design optimization will be possible when these studies are completed.« less
- Published
- 2000
34. Modeling of heat and mass transfer in accelerator targets during postulated accidents
- Author
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Kemal O. Pasamehmetoglu, Cetin Unal, and William R. Bohl
- Subjects
Convection ,Nuclear and High Energy Physics ,Molecular diffusion ,Materials science ,Mechanical Engineering ,Nuclear engineering ,chemistry.chemical_element ,Tungsten ,Thermal conduction ,Control volume ,Nuclear physics ,Nuclear Energy and Engineering ,chemistry ,Mass transfer ,Heat transfer ,General Materials Science ,Diffusion (business) ,Safety, Risk, Reliability and Quality ,Waste Management and Disposal - Abstract
The modeling of thermal-chemical behavior of targets used in accelerator applications is an important part of safety analysis. Tungsten is considered as a target material to produce tritium in a linear proton accelerator. The prediction of the chemical reactivity of tungsten in a steam flow at high temperatures is the most important part of a safety analysis of target design. The oxidation and volatilization of tungsten in steam at high temperatures is a complex phenomenon that involves various mechanisms (depending on the temperature), steam pressure, and steam velocity. A simple diffusion model that considers chemical equilibrium at the reaction interface and effective diffusion thickness, including the boundary and oxide layers, is proposed for predicting the volatilization rate. The proposed simple model predicts the available data reasonably well. The proposed model is implemented into a computer program that is developed to predict the radiological releases during postulated loss-of-coolant accidents (LOCAs). The computer program models heat production, heat transfer, and oxidation reactions in the multiple radiation enclosures representing the accelerator target elements. It treats each element of the radiation enclosures as a lumped control volume, or heat structure. Each heat structure may generate or lose heat by conduction, convection, or radiation and is subject to mass loss as a result of oxidation, melting, and volatilization. Postulated beyond-design-basis LOCAs are simulated with this computer program for the accelerator-production-of-tritium target. Sample calculations demonstrate oxidation/volatilization model capabilities and sensitivity to the assumptions selected.
- Published
- 2000
35. Modeling of radiation heat transport in complex ladder-like structures placed in rectangular enclosures
- Author
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William R. Bohl, Cetin Unal, and Kemal O. Pasamehmetoglu
- Subjects
Radiation transport ,Nuclear and High Energy Physics ,Materials science ,Mechanical Engineering ,Thermodynamics ,Radiosity (computer graphics) ,Mechanics ,Nuclear Energy and Engineering ,Thermal radiation ,Heat transfer ,Emissivity ,General Materials Science ,Decay heat ,Safety, Risk, Reliability and Quality ,Waste Management and Disposal ,Smoothing - Abstract
Complex ladder-like structures recently have been considered as the target design for accelerator applications. The decay heat, during a postulated beyond design-basis loss-of-coolant accident in the target where all normal and emergency cooling fails, is removed mainly by radiation heat transfer. Modeling of the radiation transport in complex ladder-like structures has several challenges and limitations when the standard net-radiation model is used. This paper proposes a simplified lumped, or ‘hot-rung’ model, that considers the worst elements and utilizes the standard net-radiation method. The net-radiation model would under-predict structure temperatures if surfaces were subject to non-uniform radiosity. The proposed model was assessed to suggest corrections to account for the non-uniform radiosity. The non-uniform radiosity effect causes the proposed hot-rung model to under-predict the center-rung temperatures by ≈4–74°C when all parametrics, including temperatures up to 1500°C, were considered. These temperatures are small. The proposed model predicted that an important effect of decreasing the emissivity was smoothing of non-isothermal effects. The radiosity effects are more pronounced when there are strong temperature gradients. Uniform rung temperatures tend to decrease the radiosity effects. We concluded that a relatively simple model that is conservative with respect to radiosity effects could be developed.
- Published
- 1999
36. Prognostic value of mean platelet volume on tinnitus
- Author
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Kemal, O, primary, Müderris, T, additional, Başar, F, additional, Kutlar, G, additional, and Gül, F, additional
- Published
- 2015
- Full Text
- View/download PDF
37. Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss
- Author
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Alexandra A. DeSmidt, Kemal O. Yariz, Celia Zazo Seco, Zheng-Yi Chen, Susan H. Blanton, Zhongmin Lu, Ozlem Konukseven, Na Lu, Suna Tokgoz-Yilmaz, Oscar Diaz-Horta, Hashem Shahin, Mustafa Tekin, Mingqian Huang, Theo A. Peters, Moien Kanaan, Margit Schraders, Ronald J.E. Pennings, Hannie Kremer, Xue Zhong Liu, Juan I. Young, Anne M.M. Oonk, Isaac Skromne, Julia E. Dallman, Duygu Duman, Asli Sirmaci, Jaap Oostrik, Semra Atalay, Lisette Hetterschijt, Yvonne J. K. Edwards, and Huawei Li
- Subjects
Male ,Protein family ,Adolescent ,Genetics and epigenetic pathways of disease [NCMLS 6] ,Hearing loss ,Hearing Loss, Sensorineural ,DCN PAC - Perception action and control ,Biology ,Compound heterozygosity ,Polymorphism, Single Nucleotide ,Article ,Frameshift mutation ,03 medical and health sciences ,Mice ,0302 clinical medicine ,INDEL Mutation ,medicine ,Genetics ,otorhinolaryngologic diseases ,Animals ,Humans ,Inner ear ,Genetics(clinical) ,Exome ,Genetics (clinical) ,Cochlea ,Zebrafish ,030304 developmental biology ,Vestibular system ,Chromosome Aberrations ,0303 health sciences ,Gene Expression Profiling ,Membrane Proteins ,medicine.disease ,Genetics and epigenetic pathways of disease Plasticity and memory [NCMLS 6] ,Molecular biology ,Rats ,Genetics and epigenetic pathways of disease DCN MP - Plasticity and memory [NCMLS 6] ,medicine.anatomical_structure ,Child, Preschool ,Gene Knockdown Techniques ,Mutation ,Sensorineural hearing loss ,sense organs ,medicine.symptom ,030217 neurology & neurosurgery - Abstract
Item does not contain fulltext Hereditary hearing loss is characterized by a high degree of genetic heterogeneity. Here we present OTOGL mutations, a homozygous one base pair deletion (c.1430 delT) causing a frameshift (p.Val477Glufs( *)25) in a large consanguineous family and two compound heterozygous mutations, c.547C>T (p.Arg183( *)) and c.5238+5G>A, in a nonconsanguineous family with moderate nonsyndromic sensorineural hearing loss. OTOGL maps to the DFNB84 locus at 12q21.31 and encodes otogelin-like, which has structural similarities to the epithelial-secreted mucin protein family. We demonstrate that Otogl is expressed in the inner ear of vertebrates with a transcription level that is high in embryonic, lower in neonatal, and much lower in adult stages. Otogelin-like is localized to the acellular membranes of the cochlea and the vestibular system and to a variety of inner ear cells located underneath these membranes. Knocking down of otogl with morpholinos in zebrafish leads to sensorineural hearing loss and anatomical changes in the inner ear, supporting that otogelin-like is essential for normal inner ear function. We propose that OTOGL mutations affect the production and/or function of acellular structures of the inner ear, which ultimately leads to sensorineural hearing loss.
- Published
- 2012
38. Heat transfer from a high temperature safety rod placed in a perforated guide tube and surrounded by an array of cold tubes
- Author
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Kemal O. Pasamehmetoglu and Cetin Unal
- Subjects
Nuclear and High Energy Physics ,Materials science ,Natural convection ,business.industry ,Mechanical Engineering ,Structural engineering ,Mechanics ,Guide tube ,Thermal conductivity ,Nuclear Energy and Engineering ,Heat transfer ,General Materials Science ,Tube (fluid conveyance) ,Safety, Risk, Reliability and Quality ,business ,Waste Management and Disposal ,Test data - Abstract
In this paper, a simple natural convection heat-transfer model for a safety rod placed in a perforated guide tube is proposed. The geometry is typical of the Savannah River K reactor. The proposed model for the rod and the perforated guide-tube assembly is benchmarked against prototypical test data obtained by Idaho National Engineering Laboratory. The results showed that the proposed model was in good agreement with the experimental data except at very high temperatures where the model slightly underpredicted the rod and tube temperatures. By evaluating the thermal conductivity of the fluid (air) at the wall temperature, the prediction of the high temperature natural convection data was further improved.
- Published
- 1994
39. NUMERICAL MODELING OF A NUCLEATE BOILING SURFACE
- Author
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Kemal O. Pasamehmetoglu
- Subjects
Physics::Fluid Dynamics ,Numerical Analysis ,Materials science ,Atmospheric pressure ,Boiling ,Bubble ,Heat transfer ,Nucleation ,Thermodynamics ,Heat transfer coefficient ,Condensed Matter Physics ,Thermal conduction ,Nucleate boiling - Abstract
A computer program developed to analyze nucleate boiling over a heated surface is described. The model solves the three-dimensional transient conduction equation within the heater. The conduction solution is coupled with closure relationships to mimic the bubble dynamics and the associated heat transfer coefficients. Sample problems are run using a copper surface subject to partial nucleate boiling in saturated water at atmospheric pressure. The results are shown to be in good qualitative agreement with the pertinent experimental observations.
- Published
- 1994
40. A numerical investigation of the effect of heating methods on saturated nucleate pool boiling
- Author
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Cetin Unal and Kemal O. Pasamehmetoglu
- Subjects
Materials science ,General Chemical Engineering ,chemistry.chemical_element ,Thermodynamics ,Radius ,Condensed Matter Physics ,Copper ,Atomic and Molecular Physics, and Optics ,Computer Science::Other ,Physics::Fluid Dynamics ,Nickel ,chemistry ,Heat flux ,Boiling ,Surface roughness ,Composite material ,Joule heating ,Nucleate boiling - Abstract
Using a numerical model, the effect of heating methods on saturated nucleate pool boiling is investigated parametrically for smooth and rough nickel and copper heater plates. The boiling curve moved right with decreasing thickness for the smooth and rough nickel and copper heaters in the constant-heat-flux heating method. This trend was reversed in the constant-temperature heating method; the boiling curved shifted left with decreasing heater thickness. However, the later trend was not affected by the heater material and thickness and the surface roughness (mean cavity radius). The boiling curves were identical for the constant internal generation rate and the constant-heat-flux heating method. The use of ac instead of dc resistive heating caused the boiling curve generally to move left. This behavior was not linear with the heat flux, heater material, or surface conditions. No hysterisis was found when the heat flux was increased and then decreased gradually to original values.
- Published
- 1994
41. Gravelly Liquefaction Case Histories after 2008 Wenchuan-China Earthquake Mw= 7.9
- Author
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Sahin, Arda and Cetin, Kemal O.
- Abstract
Gravelly soils were erroneously considered to be non-liquefiable due to their high capacity for pore pressure dissipation, resulting from their larger grain size. However, recent case studies have demonstrated that gravelly soils are susceptible to seismic liquefaction triggering. In particular, investigations performed in the Chengdu Plain following the 2008 Wenchuan earthquake (Mw= 7.9) provided evidence of seismic soil liquefaction in gravelly soil mixtures. Site investigations involved rotary and/or core drilling followed by dynamic cone penetration tests (DPT) and multiple channel analysis of the shear wave velocity (MASW) measurements. In 73 locations, 65 Vsmeasurements and 47 DPT-N120were taken. This paper introduces case histories with gravelly liquefiable critical layers and includes processing details. The assessment procedure includes identifying the critical layer susceptible to liquefaction, estimating the representative in-situ density state, groundwater table depth, intensity and duration parameters of seismic shaking, and gradation characteristics such as D50and D30. The resulting preliminary results were presented in the CSR vs N120and Vsdomains to enable comparisons with available liquefaction triggering methods.
- Published
- 2023
- Full Text
- View/download PDF
42. Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome
- Author
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Kemal O. Yariz, Asli Subasioglu Uzak, Duygu Duman, Mustafa Tekin, Tom Walsh, Gogsen Onalan, Michail Spiliopoulos, and Mary Claire King
- Subjects
Infertility ,Adult ,Models, Molecular ,endocrine system ,medicine.medical_specialty ,Heredity ,Protein Conformation ,Genetic counseling ,DNA Mutational Analysis ,Mutation, Missense ,Context (language use) ,Biology ,Chorionic Gonadotropin ,Article ,Structure-Activity Relationship ,Internal medicine ,medicine ,Missense mutation ,Humans ,Genetic Predisposition to Disease ,Ovarian Diseases ,Genetics ,Female infertility ,luteinizing hormone/choriogonadotropin receptor ,Homozygote ,Obstetrics and Gynecology ,Syndrome ,Receptors, LH ,medicine.disease ,Pedigree ,Endocrinology ,Fertility ,Phenotype ,Reproductive Medicine ,Mutation (genetic algorithm) ,Medical genetics ,Female ,Infertility, Female - Abstract
Objective To test by genomic analysis whether empty follicle syndrome (EFS) in a family with two affected sisters has a genetic basis. Design Whole-exome sequencing in the context of clinical genetics. Setting University hospital. Patient(s) Two women (36 and 32 years old at the time of the study) with EFS. Intervention(s) Genetic counseling based on autosomal recessive inheritance. Main Outcome Measure(s) Discovery of a mutation in the LH/choriogonadotropin receptor ( LHCGR ) as the cause of EFS. Result(s) A novel missense mutation in LHCGR , p.N400S, was homozygous in sisters with EFS and/or infertility, but not in their unaffected siblings or parents. The mutation was not present in 500 ancestry-matched control subjects. Asparagine at residue 400 is highly conserved and its substitution by serine predicted to alter critical interactions that stabilize LHCGR. Conclusion(s) We describe a genetic basis for EFS and provide strong evidence for the existence of genuine EFS in some patients. A mutation impairing the function of LHCGR explains the lack of response of these patients to repeated administration of β-hCG.
- Published
- 2011
43. Saturated pool nucleate boiling mechanisms at high heat fluxes
- Author
-
R. A. Nelson, Kemal O. Pasamehmetoglu, Padmanabha R. Chappidi, and Cetin Unal
- Subjects
Fluid Flow and Transfer Processes ,Materials science ,Vapor pressure ,Triple point ,Mechanical Engineering ,Evaporation ,Thermodynamics ,Condensed Matter Physics ,Physics::Fluid Dynamics ,Heat flux ,Closure (computer programming) ,Boiling ,Heat transfer ,Nucleate boiling - Abstract
A new model has been developed where the coupled transient two-dimensional conduction equation is solved for the heater and the liquid macrolayer, while allowing for the time-wise thinning of the macrolayer. The major conclusions are: (1) dominant evaporation occurs at the liquid-vapor-solid contact point (triple point) and is required to match boiling curve behavior quantitatively; (2) evaporation at the stem interface and bubble-macrolayer interface is negligible (except near critical heat flux); and (3) the results are sensitive to closure relationships, especially to the active site-density correlation.
- Published
- 1993
44. Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations
- Author
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Bademci, Guney, primary, Lasisi, Akeem O, additional, Yariz, Kemal O, additional, Montenegro, Paola, additional, Menendez, Ibis, additional, Vinueza, Rodrigo, additional, Paredes, Rosario, additional, Moreta, Germania, additional, Subasioglu, Asli, additional, Blanton, Susan, additional, Fitoz, Suat, additional, Incesulu, Armagan, additional, Sennaroglu, Levent, additional, and Tekin, Mustafa, additional
- Published
- 2015
- Full Text
- View/download PDF
45. The influence of surface radiation on laminar forced-convection film boiling
- Author
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F.S. Gunnerson, P.R. Chappidi, and Kemal O. Pasamehmetoglu
- Subjects
Fluid Flow and Transfer Processes ,Materials science ,Mechanical Engineering ,Thermodynamics ,Laminar flow ,Mechanics ,Condensed Matter Physics ,Leidenfrost effect ,Physics::Fluid Dynamics ,Subcooling ,Parasitic drag ,Thermal ,Heat transfer ,Shear stress ,Nucleate boiling - Abstract
A new approach to address the effect of surface radiation on a laminar film boiling flow over a horizontal flat plate is suggested. Previously developed approximate expressions of the thermal boundary-layer thickness and the wall shear stress of a moving surface in a flowing liquid are used to circumvent the complicated simultaneous solution of the vapor and liquid flow. Approximate closed-form expressions to predict the wall heat transfer and skin friction are obtained. For a water-steam system at atmospheric pressure within the wall temperature range considered (Tw
- Published
- 1991
46. Subcooled forced convection film boiling drag and heat transfer of awedge
- Author
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P.R. Chappidi, Kemal O. Pasamehmetoglu, and F.S. Gunnerson
- Subjects
Fluid Flow and Transfer Processes ,Buoyancy ,Materials science ,Mechanical Engineering ,Aerospace Engineering ,Thermodynamics ,Laminar flow ,Mechanics ,Heat transfer coefficient ,engineering.material ,Condensed Matter Physics ,Forced convection ,Space and Planetary Science ,Drag ,Parasitic drag ,Heat transfer ,engineering ,Pressure gradient - Abstract
Subcooled laminar forced convection film boiling flow on a wedge is analyzed considering the streamwise pressure gradient imposed on the flow and the streamwise buoyancy force acting on the vapor film. A twophase boundary-layer model is proposed, and the local similarity concept is applied to obtain an approximate solution of the governing equations. For a water-steam system at atmospheric pressure considered within this study, wall skin friction results display a strong dependency on the streamwise buoyancy force driving the vapor film and the external pressure gradient. Adverse streamwise buoyancy force acting on the vapor film, which is the case on the lower surface of a horizontally aligned wedge, may cause vapor flow separation. In contrast to wall skin friction dependency, the wall heat transfer parameter shows a secondary dependence on the streamwise pressure gradient and the buoyancy force.
- Published
- 1991
47. On the relationship between the macrolayer thickness and the vapor-stem diameter in the high-heat-flux, pool nucleate boiling region
- Author
-
Cetin Unal, P.R. Chappidi, R. A. Nelson, and Kemal O. Pasamehmetoglu
- Subjects
Materials science ,Heat flux ,Critical heat flux ,General Chemical Engineering ,Boiling ,Heat transfer ,Flux ,Thermodynamics ,Condensed Matter Physics ,Constant (mathematics) ,Atomic and Molecular Physics, and Optics ,Order of magnitude ,Nucleate boiling - Abstract
The authors consider the high-heat-flux, pool nucleate boiling region of a horizontal surface and propose a theoretical basis for estimating the constant of proportionality between the mean macrolayer thickness and the mean vapor-stem diameter at critical heat flux. This constant is found to be of the same order of magnitude (−10% difference) as that suggested by Gaertner [5]. While Gaertner's estimate is based on photographic evidence, the current approach uses a theoretical basis together with experimental data.
- Published
- 1991
48. Assessment of Startup Fuel Options for the GNEP Advanced Burner Reactor (ABR)
- Author
-
Kemal O. Pasamehmetoglu, Jon Carmack, and David Alberstein
- Subjects
Engineering ,Bearing (mechanical) ,Sodium-cooled fast reactor ,Nuclear transmutation ,Waste management ,Metal alloy ,law ,business.industry ,Nuclear engineering ,Combustor ,business ,Start up ,law.invention - Abstract
The Global Nuclear Energy Program (GNEP) includes a program element for the development and construction of an advanced sodium cooled fast reactor to demonstrate the burning (transmutation) of significant quantities of minor actinides obtained from a separations process and fabricated into a transuranic bearing fuel assembly. To demonstrate and qualify transuranic (TRU) fuel in a fast reactor, an Advanced Burner Reactor (ABR) prototype is needed. The ABR would necessarily be started up using conventional metal alloy or oxide (U or U, Pu) fuel. Startup fuel is needed for the ABR for the first 2 to 4 core loads of fuel in the ABR. Following start up, a series of advanced TRU bearing fuel assemblies will be irradiated in qualification lead test assemblies in the ABR. There are multiple options for this startup fuel. This report provides a description of the possible startup fuel options as well as possible fabrication alternatives available to the program in the current domestic and international facilities and infrastructure.
- Published
- 2008
49. Transmutation Fuel Campaign Description and Status
- Author
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Kemal O. Pasamehmetoglu and Jon Carmack
- Subjects
Engineering ,Engineering management ,Work breakdown structure ,Nuclear transmutation ,business.industry ,Milestone (project management) ,Leadership team ,Execution plan ,Operations management ,Technology readiness level ,Schedule (project management) ,Technology development ,business - Abstract
This report contains a technical summary package in response to a Level 2 milestone in the transmutation fuel campaign (TFC) management work-package calling for input to the Secretarial decision. At present, the form of the Secretarial decision package is not fully defined, and it is not clear exactly what will be required from the TFC as a final input. However, it is anticipated that a series oftechnical and programmatic documents will need to be provided in support of a wider encompassing document on GNEP technology development activities. The TFC technical leadership team provides this report as initial input to the secretarial decision package which is being developed by the Technical Integration Office (TIO) in support of Secretarial decision. This report contains a summary of the TFC execution plan with a work breakdown structure, highlevel schedule, major milestones, and summary description of critical activities in support of campaign objectives. Supporting documents referenced in this report but provided under separate cover include: • An updated review of the state-of-the art for transmutation fuel development activities considering national as well as international fuel research and development testing activities. • A definition of the Technology Readiness Level (TRL) used to systematically define and execute the transmutation fuel development activities.
- Published
- 2008
50. Review of Transmutation Fuel Studies
- Author
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Jon Carmack and Kemal O. Pasamehmetoglu
- Subjects
Engineering ,Waste management ,business.industry ,Nuclear engineering ,Minor actinide ,Fuel element failure ,Spent nuclear fuel ,Thorium fuel cycle ,law.invention ,Nuclear reactor core ,law ,Uranium-233 ,business ,Liquid fluoride thorium reactor ,MOX fuel - Abstract
The technology demonstration element of the Global Nuclear Energy Partnership (GNEP) program is aimed at demonstrating the closure of the fuel cycle by destroying the transuranic (TRU) elements separated from spent nuclear fuel (SNF). Multiple recycle through fast reactors is used for burning the TRU initially separated from light-water reactor (LWR) spent nuclear fuel. For the initial technology demonstration, the preferred option to demonstrate the closed fuel cycle destruction of TRU materials is a sodium-cooled fast reactor (FR) used as burner reactor. The sodium-cooled fast reactor represents the most mature sodium reactor technology available today. This report provides a review of the current state of development of fuel systems relevant to the sodium-cooled fast reactor. This report also provides a review of research and development of TRU-metal alloy and TRU-oxide composition fuels. Experiments providing data supporting the understanding of minor actinide (MA)-bearing fuel systems are summarized and referenced.
- Published
- 2008
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