45 results on '"Kilci, Hakan"'
Search Results
2. The relation between left ventricular global longitudinal strain and troponin levels in patients hospitalized with COVID-19 pneumonia
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Balaban Kocas, Betul, Cetinkal, Gokhan, Ser, Ozgur Selim, Kilci, Hakan, Keskin, Kudret, Ozcan, Safiye Nur, Verdi, Yildiz, Zeren, Mustafa Ismet, and Kilickesmez, Kadriye
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- 2021
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3. Prognostic impact of infection in octogenarians with ST-segment elevation myocardial infarction
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Gürdal, Ahmet, Keskin, Kudret, Sümerkan, Mutlu Çağan, Çetinkal, Gökhan, Kilci, Hakan, Çetin, Şükrü, and Kılıçkesmez, Kadriye Orta
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- 2020
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4. Persistent smoking rate after coronary revascularization and factors related to smoking cessation in Turkey
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Keskin, Kudret, Yildiz, Süleyman Sezai, Çetinkal, Gökhan, Çetin, Şükrü, Siğirci, Serhat, Kilci, Hakan, Aksan, Gökhan, Helvaci, Füsun, Gürdal, Ahmet, Kocas, Betül Balaban, Arslan, Şükrü, and Kiliçkesmez, Kadriye Orta
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- 2018
5. A Novel Score for an Old Enemy: Atherogenic Plasma Index Predicts In-Stent Restenosis among Stable Angina Pectoris Patients.
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Ser, Ozgur Selim, Sigirci, Serhat, Keskin, Kudret, Cetinkal, Gokhan, Kocas, Betul Balaban, Kilci, Hakan, Dalgic, Yalcin, Kalender, Erol, and Kilickesmez, Kadriye
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BLOOD plasma ,SURGICAL stents ,CORONARY restenosis ,ANGINA pectoris ,LOGISTIC regression analysis - Abstract
Objectives: Although the association of Atherogenic index of plasma (AIP) with coronary artery disease (CAD) and atherosclerosis is known, the relationship between AIP and in-stent restenosis (ISR) remains unclear. We aimed to investigate the relationship between AIP and ISR in patients with stable angina pectoris (SAP) treated with drug-eluting stent (DES). Methods: Patients with a history of DES implantation following stable angina were evaluated between January 2015 and November 2019 in this observational and retrospective study. 608 eligible patients were dichotomized into ISR+ (n=241) and ISR-(n=367). ISR was defined as the presence of 50% or greater stenosis. AIP was defined as log [TG/HDL-C]. Results: AIP levels were significantly higher in patients who developed ISR compared with those who did not (0.33 [0.15-0.52] vs 0.06 [-0.08-0.21] respectively, p<0.001). The AUC value of AIP levels for predicting ISR was 0.746 (p<0.001). Multivariate logistic regression analysis revealed that AIP, diabetes mellitus, higher LDL-C levels and lower LVEF values were independently associated with ISR. Conclusion: Multivariate analysis revealed that AIP was strongly independently associated with ISR. Using this novel inexpensive and easily calculable index may provide early recognition of ISR in patients with SAP who were treated with DES. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Association Between Serum Irisin Levels and ST-Segment Elevation Myocardial Infarction
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Ozturk, Derya, primary, Melekoglu, Adem, additional, Altinbilek, Ertugrul, additional, Calik, Mustafa, additional, Kosem, Arzu, additional, Kilci, Hakan, additional, Misirlioglu, Naile Fevziye, additional, and Uzun, Hafize, additional
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- 2023
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7. The predictive value of stress hyperglycemia on thrombus burden in nondiabetic patients with ST-segment elevation myocardial infarction
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Sigirci, Serhat, Yildiz, Süleyman S., Keskin, Kudret, Cetinkal, Gokhan, Aksan, Gokhan, Gürdal, Ahmet, Çetin, Şükrü, Kilci, Hakan, and Kilickesmez, Kadriye O.
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- 2019
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8. Effects of Atrioventricular Blocks in Acute Coronary Syndrome: Long-Term Follow-Up.
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Sumerkan, Mutlu Cagan, Kalender, Erol, Kilci, Hakan, Gurdal, Ahmet, Keskin, Kudret, Sigirci, Serhat, and Alyan, Omer
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ATRIOVENTRICULAR node ,ACUTE coronary syndrome ,SYSTOLIC blood pressure ,PATIENTS' attitudes ,MORTALITY - Abstract
Objectives: Arrhythmias are the common, potentially lethal, and treatable complication of acute coronary syndrome (ACS). Arrhythmic findings of ischemic cardiac events are well-known, but long-term results have not been scrutinized. In the study, we aimed to analyze the long-term findings of the atrioventricular block (AVB) in ACS patients. Methods: This is a single-center and retrospective study of patients admitted with ACS and AVB. The primary endpoint has combined the outcome of major adverse cardiovascular events and mortality. Results: Seventy-six (89.4%) patients had 3rd-degree AVB. Fifty (58.8%) patients are needed for temporary ventricular pacing and 4 (4.7%) for a permanent pacemaker. Although no cardiac death occurred during the 5-year follow-up period, the in-hospital mortality ratio was 30.6%. Patients with older age and lower systolic blood pressure (SBP) levels had higher mortality rates (respectively, odds ratio [OR] 1.088, [p=0.003], OR 0.912, [p<0.001]). Even in ST-segment elevation myocardial infarction and complete AVB subgroup analyses, mortality rates were associated with SBP and age (respectively, OR: 0.917, [p<0.001], OR: 1.107 [p=0.002]), (respectively, OR: 0.917 [p<0.001], OR: 1.087 [p=0.004]). Conclusion: The study results are associated with a better long-term overall prognosis in patients with ACS with AVB, but lower SBP and older in-hospital follow-up are associated with poor prognosis. [ABSTRACT FROM AUTHOR]
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- 2023
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9. In-Hospital Bleeding in Elderly Patients With Acute Coronary Syndrome: Are Potent Antiplatelet Agents Safe?
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Keskin, Kudret, primary, Sığırcı, Serhat, additional, Gürdal, Ahmet, additional, Ser, Özgür S., additional, Kilci, Hakan, additional, Sümerkan, Mutlu Ç., additional, Er, Arzu, additional, and Alyan, Ömer, additional
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- 2022
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10. The relationship between renal functions and thrombolysis in myocardial infarction frame count in patients with slow coronary flow
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Koc, Fatih, Kalay, Nihat, Kilci, Hakan, Ceyhan, Koksal, Celik, Atac, Kadi, Hasan, Calapkorur, Bekir, Celik, Ahmet, and Onalan, Orhan
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- 2011
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11. Relation of a novel fibrosis marker and post-myocardial infarction left ventricular ejection fraction in revascularized patients
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Kilci, Hakan, primary, Altınbilek, Ertuğrul, additional, Çetinkal, Gökhan, additional, Sığırcı, Serhat, additional, Koçaş, Betül B, additional, Yıldız, Süleyman S, additional, and Kılıçkesmez, Kadriye Orta, additional
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- 2021
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12. Comparison of Sequential POT-Side-POT and Kissing Balloon Techniques in Patients with Coronary Bifurcation Lesions Treated with Single-Stent Strategy; Which One is Simple and Safe? Propensity Score Analysis.
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Çetinkal, Gökhan, Koçaş, Betül Balaban, Keskin, Kudret, Kilci, Hakan, Ser, Özgür Selim, and Kılıçkesmez, Kadriye
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CORONARY disease ,INTRA-aortic balloon counterpulsation ,KISSING ,ACUTE kidney failure ,HOSPITAL mortality - Abstract
Background: It is unknown whether the novel POT-side-POT technique is more useful than the commonly preferred kissing balloon inflation in patients with non-complex coronary bifurcation lesions treated with a single-stent strategy. The aim of this study was to compare the efficacy of POT-side-POT and kissing balloon inflation techniques in onestent strategy for non-complex coronary bifurcation lesions. Methods: In this study, 283 patients were retrospectively analyzed (POT-side-POT group, n = 149; KBI group, n = 134). Primary endpoints of the study were defined as follows: inhospital and 30-day mortality, contrast-induced acute kidney injury, stent thrombosis, side branch dissection, and need for side-branch stenting. Characteristics of patients at baseline were balanced by using propensity score inverse probability weighting. Results: Procedure time (minute, 30.6 ± 8.5 vs. 34.3 ± 11.6; P = .003) and contrast volume (milliliter, 153.7 ± 42.4 vs. 171.1 ± 58.2; P = .004) were significantly lower in POT-side-POT group. Besides, side branch residual stenosis and number of patients with >50% side branch residual stenosis remained significantly higher in POT-side-POT group both in general and true bifurcation subgroup analysis (20.3 ± 19.8% vs. 16.5 ± 16.4%, P = .022; 11.9% vs. 5.7%, P = .013 and 24.1 ± 23.2% vs. 18.8 ± 18.7%, P = .033; 17.6% vs. 6.6%, P = .005; respectively). Combined clinical adverse outcomes were similar between groups. Side branch dissection (10.2% vs. 20.1%, P = .001) and need for side branch stenting (12.6% vs. 19%, P = .040) reached statistically significance in kissing balloon inflation group after adjustment. Conclusion: POT-side-POT may be a simple and safe technique with a shorter procedure time and lower incidence of adverse clinical events in non-complex coronary bifurcation lesions treated with single-stent strategy. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Interarm blood pressure differences and 2-year mortality in acute coronary syndrome patients
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Kilic, Ismail Dogu, primary, Kilci, Hakan, additional, Sevgican, Cihan Ilyas, additional, Kilinc, Mehmet, additional, Ozden Tok, Ozge, additional, Oguz, Ibrahim, additional, Ghilencea, Liviu, additional, Senol, Hande, additional, and Kilickesmez Orta, Kadriye, additional
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- 2021
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14. The relation between left ventricular global longitudinal strain and troponin levels in patients hospitalized with COVID-19 pneumonia
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Balaban Kocas, Betul, primary, Cetinkal, Gokhan, additional, Ser, Ozgur Selim, additional, Kilci, Hakan, additional, Keskin, Kudret, additional, Ozcan, Safiye Nur, additional, Verdi, Yildiz, additional, Zeren, Mustafa Ismet, additional, and Kilickesmez, Kadriye, additional
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- 2020
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15. The Utility of the Novel Hematologic Parameters for Predicting in Hospital Mortality in Patients with Acute Mesenteric İschemia
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YILDIZ, Süleyman Sezai, primary, AVŞAR, Murat, additional, ERCAN, Gülçin, additional, SIĞIRCI, Serhat, additional, AKSAN, Gökhan, additional, and KİLCİ, Hakan, additional
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- 2019
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16. Reply to the Letter to the Editor Entitled “Which Comes First in Contrast-Induced Nephropathy? Inflammation or Thrombus Formation?”
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Sigirci, Serhat, primary, Keskin, Kudret, additional, Yildiz, Suleyman Sezai, additional, Cetinkal, Gokhan, additional, Gurdal, Ahmet, additional, Kilci, Hakan, additional, Tezcan, Mehmet, additional, and Kilickesmez, Kadriye Orta, additional
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- 2019
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17. Lise öğrencilerinin beden eğitimi dersine ilişkin tutumlarının sağlıklı yaşam biçimi davranışları üzerine etkisi
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Kilci, Hakan, Demirdöken, Çisem, Ünlü, Çisem, and Beden Eğitimi ve Spor Ana Bilim Dalı
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Healthy Life ,Behavior ,Tutum ,Physical education and sports lesson ,Beden eğitimi ,High schools students ,Physical education and training ,Spor ,Davranış ,Attitude ,Attitudes ,Life style ,Physical Education ,Sağlıklı Yaşam ,Healthy life ,Sports - Abstract
Bu çalışmada, farklı okul türlerinde öğrenim gören lise öğrencilerinin beden eğitimi dersine yönelik tutumların sağlıklı yaşam biçimi davranışı üzerine etkisini araştırmak amacıyla yapılmıştır. İnsanın yapısı gereği bir olaya karşı duygu ve düşüncesi, ilerde yapacağı davranışları etkilemektedir. Bu araştırmada da tutumların davranış biçimlerine olan etkisi araştırılmıştır. Araştırmanın evrenini Çorum ilinde öğrenim gören lise öğrencileri oluşturmaktadır. Araştırmaya 1143 kadın ve 873 erkek olmak üzere 2016 öğrenci gönüllü olarak katılmıştır. Veri toplama aracı olarak üç bölümden oluşan anket formu uygulanmıştır. Anket içerisindeki bölümlerin ilkinde demografik özellikleri öğrenmek üzere araştırmacı tarafından hazırlanan 'Kişisel Bilgi Formu', ikinci bölümde Güllü ve Güçlü (2009) tarafından geliştirilen 'Beden Eğitimi Dersine Yönelik Tutum Ölçeği' ve son bölümde ise Bahar ve diğ. (2008) tarafından geliştirilen 'Sağlıklı Yaşam Biçimi Davranış Ölçeği II' yer almaktadır. Elde edilen veriler SPSS programı yardımı ile %95 güven düzeyinde test edilmiştir ve anlamlılık düzeyi 0,05 olarak belirlenmiştir. Yapılan normallik testleri neticesinde, veriler normal dağılımdan geldiğinden T-Testi ve Anova testi yapılmıştır. Aynı zamanda beden eğitimi dersine ilişkin tutumlarının sağlıklı yaşam biçimi davranışları üzerine etkisine korelasyon ve regresyon testleri ile bakılmıştır. Araştırmamızın sonucunda beden eğitimi dersine yönelik tutumların sağlıklı yaşam biçimi davranışları ile anlamlı bir farklılık göstermesi ve beden eğitimi dersine ilişkin tutumların sağlıklı yaşam davranışlarının gelişmesinde büyük bir etkiye sahip olmasıdır. Araştırmaya katılan öğrencilerin demografik özelliklerinin beden eğitimi dersine yönelik tutumlarında ve sağlıklı yaşam davranışlarında büyük etkiye sahip olduğu anlaşılmıştır. In this study, is applied fort he impact of the attitude of different high school students related to physical education on healthy lifestyle behaviours. Naturally, human beings feelings and opinions to a situation olso impact their future behaviours. In this study, it is researched the impacts of attitudes on behaviours. The Universe of the study consist of high school students in Çorum. 1143 women and 873 men have joined the study as voluntarily. A questionnaire consisting of 3 sections was used as a data collection tool. In the questionnaire the first part is ''Personal Information Form'' to learn the demographic properties; the second part is ''The scale of Attitude to Physical Education'' developed by Güllü and Güçlü (2009) and the last part is ''The Scale of Healthy Lifestyle Behaviour II'' developed by Bahar and her friends (2008). The gathered data is tested by SPSS program with %95 accuracy and mentioned the significance level as 0,05. After normality tests, because the data was distributed normally, T-test and Anova test was applied. Also, it has been taken in hand the attitude of high school students related to physical education on healthy lifestyle behaviours by Correlation and Regression Tests. The result of the study, it is seen that there is a signicant difference in impact of the attitude of high school students related to physical education on healthy lifestyle behaviours and there is a great impact to develope the attitude of high school students related to physical education on healthy lifestyle behaviours. It is seen that student demographic properties, joined the study, have a great impact on the attitude related to physical education and impact on healthy lifestyle behaviours. İÇİNDEKİLER Sayfa KABUL VE ONAY -- iii ETİK BEYANNAMESİ -- iv ÖNSÖZ -- v İÇİNDEKİLER -- vi KISALTMALAR VE SEMBOLLER -- viii ÇİZELGELER LİSTESİ -- ix ŞEKİLLER LİSTESİ -- xii ÖZET -- xiii SUMMARY -- xiv 1. GİRİŞ -- 1 1.1 Çalışmanın Amacı ve Önemi -- 2 1.2 Problemler -- 3 1.3 Hipotezler -- 7 1.4 Sınırlılıkları -- 11 1.5 Sayıltılar -- 11 2. GENEL BİLGİLER -- 12 2.1 Beden Eğitimi ve Spor -- 12 2.1.1 Beden eğitimi dersinin amaç ve önemi -- 15 2.1.2 Beden eğitimi öğretim stilleri -- 17 2.1.3 Beden eğitimi ve sporun genel amacı -- 18 2.1.3.1 Kişisel yönden -- 18 2.1.3.2 Toplumsal açıdan -- 19 2.1.3.3 Ekonomik yararlılık -- 19 2.1.4 Milli Eğitim Bakanlığı ve beden eğitimi dersi -- 20 2.2 Tutum -- 21 2.2.1 Tutumun ögeleri -- 25 2.2.2 Tutumun oluşumu -- 26 2.2.3 Tutum ve davranış arasındaki ilişki -- 27 2.2.4 Beden eğitimine karşı tutumlar -- 28 2.3 Sağlıklı Yaşam -- 28 2.3.1 Sporun yaşamımızdaki yeri -- 31 2.3.1.1 Duygusal ve sosyal gelişim -- 32 2.3.1.2 Organik gelişim -- 34 2.3.1.3 Zihinsel gelişim -- 34 2.3.2 Stres yönetimi -- 34 2.3.3 Sağlıklı yaşam için bireylere düşen sorumluluklar -- 36 3. MATERYAL VE YÖNTEM -- 38 3.1 Araştırmanın Ön Kabulleri -- 38 3.2 Araştırmaya Alınma ve Araştırmadan Dışlanma Kriterleri -- 38 vii 3.2.1 Araştıramaya dahil edilme kriterleri -- 38 3.2.2 Araştırmanın dışlanma kriterleri -- 38 3.3 Araştırmanın Evreni ve Örneklem Yöntemi -- 39 3.4 Araştırmanın Yöntemi -- 40 3.5 Araştırmanın Veri Toplama Aracı -- 40 3.5.1 Bölüm 1: Kişisel bilgi formu -- 40 3.5.2 Bölüm 2: Ortaöğretim öğrencileri için beden eğitimi dersi tutum ölçeği . 41 3.5.3 Bölüm 3: Sağlıklı yaşam biçimi davranışları ölçeği II -- 41 3.6 Verilerin Toplanması -- 42 3.7 Verilerin Değerlendirilmesi -- 43 3.8 Araştırmanın Etik Yönü -- 43 4. BULGULAR -- 44 5. TARTIŞMA -- 76 6. SONUÇ VE ÖNERİLER -- 87 KAYNAKLAR -- 90 EKLER -- 94 ÖZGEÇMİŞ -- 10
- Published
- 2019
18. Siyasal Krizler Karşısında Liderlerin Davranışları ve Ekonomiye Etkileri
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KANTAR, Gökmen, GÜLAY, İhsan, and KILCI, Hakan
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Social ,Siyasal kriz,liderlik,kriz yönetimi,ekonomik kriz ,Political crisis leadership,crisis management,economic crisis ,Sosyal - Abstract
We see that the level of development in the countriesaround the world is related to the economy, when we examine welfare levels. Themoney of countries with strong economies is more valuable than the money ofother countries. In addition, according to the economic value of the moneycountries, other countries will have influence or remain under the influence.In the process of becoming an economic power, there are many dynamic factorsfrom production to technology, marketing to raw material. One of the processesof generating economic value is related to how the country is governed.Politicians, bureaucrats and leaders who govern the country have a great shareof the economy of that country, good or bad. Fluctuations or crises may occurin the economies of the country over time. The reason for these fluctuationscan be social and social as well as political developments can be effective. Anumber of positive or negative developments in the political sphere lead to thegood or bad economy of the country. Crises have a very dynamic impact on thecountry's economies. The successful management of these crises ensures that theeconomy of the country is overcome without being adversely affected. In theface of these crises, the rulers of the country, together with their owncapabilities, combine their knowledge and experience to form an effectivemanagement. In this study, following the negative politicaldevelopments in our close political history in Turkey, the behavior of theleaders, the forms of administration against these crises, and theirreflections on the economy were investigated., Dünya üzerinde bulunan ülkelerin, refah düzeyleriniincelediğimiz de gelişme seviye oranlarının, ekonomi ile ilişkili olduğunugörürüz. Ekonomisi güçlü olan ülkelerin parası, diğer ülke paralarına göre dahadeğerlidir. Ayrıca parasının ekonomik değerine göre ülkeler, diğer ülkelerüzerinde nüfuz sahibi olur veya etkisi altında kalır. Bu ekonomik güç olmasürecinde üretimden-teknolojiye, pazarlamadan-hammaddeye kadar birçok dinamikfaktör iktisaden söz konusudur. Ekonomik değer üretme süreçlerinden birisi deülkenin nasıl yönetildiği ile ilişkilidir. Ülkeyi yöneten, politikacılar,bürokratlar ve liderler o ülkenin ekonomisine; iyi veya kötü büyük payasahiptirler. Zaman içinde ülke ekonomilerinde dalgalanmalar veya krizleryaşanabilir. Bu dalgalanmaların sebebi, sosyal ve toplumsal olabileceği gibisiyasal gelişmeler de etkili olabilir. Siyasal alanda yaşanan bir takım olumluya da olumsuz gelişmeler, ülke ekonomisinin iyi veya kötü gitmesine yol açar.Krizler ülke ekonomileri üzerinde, çok dinamik bir etkiye sahiptir. Bukrizlerin başarıyla yönetilmesi, ülke ekonomisinin olumsuz anlamda, çok dahafazla etkilenmeden aşılmasını sağlar. Bu krizler karşısında ülkeyi yönetenler,kendi yetenekleri ile beraber; bilgi ve tecrübelerini birleştirerek etkin biryönetim biçimi ortaya koyarlar. Bu çalışmada Türkiye’de yakın siyasitarihimizde, meydana gelen olumsuz siyasi gelişmelerin ardından; liderlerindavranışları, bu krizler karşısındaki yönetim biçimleri ve bu tutumların,ekonomiye olan yansımaları araştırılmıştır.
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- 2018
19. Presence of fragmented QRS may be associated with complex ventricular arrhythmias in patients with essential hypertension
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Bekar, Lütfü, primary, Kalçık, Macit, additional, Kilci, Hakan, additional, Çelik, Oğuzhan, additional, Yetim, Mucahit, additional, Doğan, Tolga, additional, and Önalan, Orhan, additional
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- 2019
- Full Text
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20. Reply to the Letter to the Editor Entitled “What Are the Essential Risk Factors for Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?”
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Sigirci, Serhat, primary, Keskin, Kudret, additional, Yildiz, Suleyman Sezai, additional, Cetinkal, Gokhan, additional, Gurdal, Ahmet, additional, Kilci, Hakan, additional, Tezcan, Mehmet, additional, and Kilickesmez, Kadriye Orta, additional
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- 2019
- Full Text
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21. Can Thrombus Burden Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?
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Sigirci, Serhat, primary, Keskin, Kudret, additional, Yildiz, Süleyman Sezai, additional, Cetinkal, Gökhan, additional, Gurdal, Ahmet, additional, Kilci, Hakan, additional, Tezcan, Mehmet, additional, and Kilickesmez, Kadriye Orta, additional
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- 2019
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22. THE ROLE AND IMPORTANCE OF PUBLIC LIGHTNING AND TRANSPARENCY IN CORPORATE GOVERNANCE
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KILCI, Hakan
- Subjects
Kamuyu Aydınlatma,Denetim,Kurumsal Yönetim ,Lighting public,Auditing,Corporate Governance - Abstract
Kurumsal yönetim işletmelerde yaşanan büyük boyutlardaki yolsuzluklar nedeniyle iflas eden işletmelerin paydaşlar, pay sahipleri, kamu ve devleti çok fazla ilgilendiren bir konu olması nedeniyle yönetim biliminde fazlaca araştırma yapılan bir alan olmaya başlamıştır. İşletmelerin iflasa sürüklenmesinden önce bazen yönetim kurullarının dahi farkına varamadığı, icracıların yönetim kurulundan dahi gizli tutmayı başarabildiği bazı faaliyet ve rakamların hiç beklenmedik bir anda ortaya çıkıp işletmeyi çıkmazlara sürükleyip iflas ettikleri görülmektedir. Çalışan sayısı ve sektörde edindiği önemli yer nedeniyle tüm ülke ekonomisini etkileyecek kadar büyük işletmelerin iflas etmeleri elbette ki sadece işletme sahiplerini ( büyük pay sahipleri) değil işletme ile ilgili tüm çıkar gruplarını (hisse senedi sahipleri, iş görenler, devlet, kamuoyu, tedarikçiler, dağıtıcılar vb) yakinen ilgilendirmektedir. Bu araştırma da geçmişte yaşanan iflas olaylarında kurumsal yönetimin dört ilkesinden biri olan kamuyu aydınlatma ve şeffaflık ilkesini ihlal etmenin ne gibi sonuçlar doğurduğu, ihlallerin ne şekilde yapıldığı ve manipülasyonların (farklı göstermelerin) ne şekilde yürütüldüğü açıklanmaya çalışılmıştır. İşletmelerin yayınlaması gereken ve iş sırrı olmayan belgelerin ve bilgilerin yayınlanması işletmenin kurumsal yönetiminde çok önemli bir işleve sahiptir. Zira kamuoyu bu bilgiler sayesinde işletmenin gidişatı ve faaliyetleri hakkında bilgi sahibi olmakta ve önemli kararlarını bu bilgiler vasıtasıyla vermektedir. Ayrıca işletmelerde yönetim kurulları tarafından oluşturulan denetim komitelerinin şeffaflık ve kamuoyunu aydınlatma ilkesini ihlal eden yönetim kurulu ve icracı yöneticilerin denetlenmesine ve ihlallerin engellenmesine yardımcı olacağı açıktır. Bu araştırmada ilgili komitelerin de yürüttükleri faaliyetler ve yapıları açıklanmaya çalışılmıştır, Corporate governance has become an area of much research in management science beause to the large scale companies’ corruption it is a topic that interests stakeholders, shareholders, the public and the state. Before the entities are dragged into business it is seen that some operations and figures, which sometimes have not even noticed by the board of directors, and that even the executives have been able to keep secrets even from the board of directors, have unexpectedly dragged into bankruptcy. Of course, the bankruptcies of large enterprises that affect the entire country's economy because of the number of employees and the important place in the sector, of course, are not limited to only business owners (large shareholders), but all business interest groups (shareowners, employees, state, public opinion, suppliers, ) very closely related. This research has tried to explain the consequences of violating the principle of transparency and transparency, which is one of the four principles of corporate governance in the past bankruptcy incidents, how the violations are made and how the manipulations (different manifestations) are carried out. Publishing documents and information that businesses need to publish and which are not business secrets has a very important role in the enterprise management of the business. Because of this information, the public is informed about the direction and activities of the business and makes important decisions through this information. It is also clear that auditing committees established by management boards in the enterprises will help to control the board and executive managers who violate the principle of transparency and public disclosure and to prevent violations. In this research, the related committees also tried to explain the activities and the activities they carried out
- Published
- 2017
23. Usefulness of Serum Omentin-1 Levels for the Prediction of Adverse Cardiac Events in Patients with Hypertrophic Cardiomyopathy
- Author
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Yıldız, Suleyman Sezai, primary, Sahin, Irfan, additional, Cetinkal, Gokhan, additional, Aksan, Gokhan, additional, Kucuk, Suat Hayri, additional, Keskin, Kudret, additional, Cetin, Sukru, additional, Sigirci, Serhat, additional, Avcı, İlhan İlker, additional, Kilci, Hakan, additional, and Kiliçkesmez, Kadriye, additional
- Published
- 2018
- Full Text
- View/download PDF
24. Persistent smoking rate after coronary revascularization and factors related to smoking cessation in Turkey
- Author
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Keskin, Kudret, primary, Sezai Yıldız, Süleyman, additional, Çetinkal, Gökhan, additional, Çetin, Şükrü, additional, Sığırcı, Serhat, additional, Kilci, Hakan, additional, Aksan, Gökhan, additional, Helvacı, Füsun, additional, Gürdal, Ahmet, additional, Balaban Kocaş, Betül, additional, Arslan, Şükrü, additional, and Orta Kılıçkesmez, Kadriye, additional
- Published
- 2017
- Full Text
- View/download PDF
25. The Utility of the Novel Hematologic Parameters for Predicting in Hospital Mortality in Patients with Acute Mesenteric Ischemia
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YILDIZ, Suleyman Sezai, primary, AVSAR, Murat, additional, ERCAN, Gulcin, additional, SIGIRCI, Serhat, additional, AKSAN, Gokhan, additional, and KILCI, Hakan, additional
- Published
- 2017
- Full Text
- View/download PDF
26. Tekirdağ İl ve İlçelerinde Kadın Girişimcilik Kültürü ve Makro Ekonomiye Etkileri ve Sonuçları; Alınması Gereken Tedbirler ve Çözüm Önerileri
- Author
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BAKKAL, Muharrem, BAKKAL, Süreyya, KILCI, Hakan, and AKARÇAY, Nermin
- Subjects
Girişimcilik,Kadın Girişimcilik,Makro Ekonomi,Gayri Safi Milli Hasıla,Tekirdağ İli - Abstract
Girişimcilik ülke ekonomisine, bireylerin ekonomik faaliyetlerine katkıda bulunan ekonomik hayatın en önemli faaliyetlerindendir. Özellikle ekonominin en önemli göstergelerinden biri olan gayri safi milli hâsılanın arttırılması ekonomik büyüme olarak bilinmektedir ve bunu sağlamanın yolu girişimciliktir. Girişimcilik aracılığıyla işletmeler daha fazla mal ve hizmet üreterek ekonominin büyümesine katkıda bulunurlar. Bu yüzden girişimciliğin teşvik edilmesi, girişimcilik ruhuna ve potansiyeline sahip bireylerin cesaretlendirilmesi ve projelerini hayata geçirme konusunda desteklenmesi çok önemli bir konudur.Kadın girişimcilik konusu ülkemizde kadınların iş hayatına girmeleri konusunu ele almaktadır. Dünya genelinde birçok ülkede kadınların iş hayatına girmesi konusunda teşvikler bulunmaktadır. Batı Avrupa ülkeleri ve Amerika kültüründe kadının iş hayatında aktif olarak rol alması Asya ve İslam ülkelerine göre daha fazladır. Ülkemizde tipik bir İslam ülkesi olarak kadın müteşebbisliğin çok gelişmemiş olduğu bir ülke olarak kabul edilebilir. Ekonomistlerin, sosyologların bir sorun olarak düşündükleri bu durumun değiştirilmesi ve kadınların girişimci olarak iş hayatında yer alması istenilmektedir.Bu çalışmada özellikle kadın girişimcilik konusunun üzerinde durulmuş Tekirdağ ilinde faaliyet gösteren kadın girişimcilerin sorunları incelenmiş ve çözüm önerilerinde bulunulmuştur.
- Published
- 2014
27. Incidental Right Atrial Thrombus in an 18-Year-Old Female Patient.
- Author
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Kilci, Hakan, Keskin, Kudret, Aksan, Gökhan, Yıldız, Süleyman Sezai, and Kılıçkesmez, Kadriye Orta
- Subjects
- *
HEMODIALYSIS patients , *CARDIAC magnetic resonance imaging , *THROMBOSIS , *RIGHT heart atrium , *WOMEN patients , *DIALYSIS catheters - Abstract
Thrombus formation in the right atrium has been quite rare and is generally associated with venous thromboembolism and foreign bodies in the right heart chambers. However, as more permanent hemodialysis catheters are implanted into patients with an end-stage renal disease, the incidence of right heart thrombus tends to increase. Unfortunately, despite its high mortality rate, there is no consensus on its treatment. In our case, a right atrial mass in an 18-year-old asymptomatic female patient who has been on peritoneal dialysis for many years due to end-stage renal disease was incidentally found. Her medical history included the placement of a jugular hemodialysis catheter due to peritonitis. During patient’s diagnostic workup, cardiac magnetic resonance imaging was performed where the features of the mass were consistent with thrombus. After a 3-month course of anticoagulation, the thrombus resolved completely. Cardiac magnetic resonance imaging with its high sensitivity and specificity plays a pivotal role in identifying thrombi of rare locations. Anticoagulation in the absence of absolute contraindication may be the first option in catheter-related thrombus cases. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
28. Kronik obstrüktif akciğer hastalığında sağ ventrikül diyastolik fonksiyonun değerlendirilmesi
- Author
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Yemenici, Hasibe, Yılmaz, Ayşe Aslı Şahin, Kilci, Hakan, Ceyhan, Köksal, Etikan, İlker, Doruk, Sibel, Önalan, Orhan, Gaziosmanpaşa Üniversitesi, and 0-Belirlenecek
- Subjects
Solunum Sistemi ,Genel ve Dahili Tıp - Abstract
Amaç: Kronik obstrüktif akciğer hastalığı (KOAH) tam olarak geri dönüşümü olmayan havayolu kısıtlılığı ile karakterize sistemik bir hastalıktır. Pulmoner hipertansiyona (PH) ikincil gelişen sağ ventrikül hipertrofisi ve/veya dilatasyonu olarak tanımlanan kor pulmonale KOAH’ın takibinde önemli bir prognostik faktördür. KOAH olgularında, sağ ventrikül diyastolik fonksiyonlarının değerlendirilmesi ve buna etki eden faktörlerin belirlenmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya, 40 KOAH’lı hasta ve 24 sağlıklı kontrol grubu alındı. Tüm olgulara solunum fonksiyon testi ve doku doppler ekokardiyografi yapıldı. Bulgular: Hasta ve kontrol grubu arasında triküspit annuler sistolik hız (S), triküspit annulus erken diastolik hız (E) ve triküspit annulus geç diastolik hız (A) açısından anlamlı fark saptanmadı (p>0.05). E/A oranı, İVRT değeri açısından gruplar arasında anlamlı farklılık saptandı (sırasıyla, p=0.05, p=0.0001). FEV1 ile E/A arasındaki korelasyon pozitif yönde anlamlı idi (r=0.409, p=0.009). Diğer EKO parametreleri ile SFT değerleri ve AKG analizi arasındaki karşılaştırmalarda anlamlı korelasyon saptanmadı. SatO2?%90 olan KOAH olgularında, SatO2>%90 olan hastalara göre E değerinde ve E/A oranında azalma anlamlıydı (her ikisi için p=0.002). PH (PABsis>30 mmHg) olan KOAH olgularında, PH olmayanlara göre E ve E/A oranındaki azalma anlamlıydı (sırasıyla, p=0.016, p=0.01). PABsis ile FEV1 ve FEV1/ FVC değeri arasındaki korelasyon anlamlı değildi. PABsis ile pO2 değeri arasında negatif yönde, pCO2 değeri arasında pozitif yönde anlamlı korelasyon bulundu (sırasıyla, p=0.006, p=0.029). FEV1 ile satO2 ve pO2 arasında pozitif yönde anlamlı korelasyon saptandı (sırasıyla, p=0.018, p=0.001). Sonuç: KOAH’lı olgularda sağ kalp fonksiyonlarının açısından yalnızca sistolik değil diyastolik fonksiyonların da değerlendirilmesini önemlidir. (Turk Toraks Derg 2012; 13: 152-7) Objective: Chronic obstructive lung disease (COPD) is a systemic disease characterised by airflow limitation that is not fully reversible. Right ventricular diastolic function (rvdf) was investigated in COPD. Material and Methods: Study groups consisted of 40 patients with COPD and 24 healthy controls. All subjects performed respiratory function test and doppler echocardiography. Results: There was no statistical difference between patient and control groups with respect to tricuspid annular systolic velocity (S), tricuspid annulus early diastolic filling velocity (E) and tricuspid annulus late diastolic velocity (A) (p>0.05). For E/A ratio and İVRT, there was a statistical difference between groups (p=0.05, p=0.0001). There was a positive correlation between FEV1 and E/A ratio (r=0.409, p=0.009). There was no statistically significant correlation between other parameters of Echocardiography (Echo), RFT and arterial blood gas (ABG) analysis comparisons. Decrease in E and E/A ratio in COPD whose SatO2≤%90 was statistically significant compared to patients with SatO2>%90 (p=0.002). Decreases in E and E/A rates were significant between COPD cases with PH (pulmonary artery pressure PABsis>30 mmHg), and those without PH (p=0.016, p=0.01). There was no statistically significant correlation between PABsis and FEV1 and FEV1/FVC. There was a negative correlation between PABsis and pO2, and positive correlation between PABsis and pCO2 (p=0.006, p=0.029). There was a positive correlation between FEV1, pO2 and satO2 (p=0.018, p=0.001). Conclusion: As a result, we concluded that, in order to evulate right ventricular functions in COPD cases, we must not only consider systolic functions but also examining the diastolic functions is important. Doppler-Echo proved to be favorable in evaluating rvdf in all COPD patients. (Turk Toraks Derg 2012; 13: 152-7)
- Published
- 2012
29. Acute pancreatitis and pseudomyocardial infarction
- Author
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Bekar, Lütfü, Önalan, Orhan, Kilci, Hakan, Altunkaş, Fatih, Burucu, Turgay, Gaziosmanpaşa Üniversitesi, and 0-Belirlenecek
- Subjects
Tıbbi Araştırmalar Deneysel ,cardiovascular diseases - Abstract
Akut pankreatit olgularında nadiren akut miyokard enfarktüsünü andıran EKG değişiklikleri gözlenebilir. Bu hastalarda trombolitik tedavinin ölümcül seyredebileceği bildirilmiştir. Biz burada göğüs ağrısı ile başvuran ve akut miyokard enfarktüsünü düşündüren EKG değişiklikleri olan akut pankreatitli bir hastayı sunduk. Electrocardiographic changes in acute pancreatitis may mimic acute coronary syndromes. Thrombolytic therapy has been reported to be fatal in such patients. Here we present a case of acute pancreatitis presented with chest pain and ECG changes suggesting acute myocardial infarction.
- Published
- 2010
30. Plasma adhesion molecules in patients with atrial fibrillation
- Author
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Kilci, Hakan, Ceyhan, Köksal, and Kardiyoloji Ana Bilim Dalı
- Subjects
Kardiyoloji ,Arrhythmia-cardiac ,Rheumatic diseases ,Heart diseases ,Adhession moleculs ,Heart valve diseases ,Cardiology ,Atrial fibrillation ,Rheumatic heart disease - Abstract
Atrial fibrilasyon (AF) klinik pratikte en sık karşılaşılan sürekli aritmi biçimidir. Nonvalvüler atriyal fibrilasyonu (NVAF) olan hastalarda inme riski yaklaşık 5 kat, valvüler atriyal fibrilasyonu (VAF) olan hastalarda ise 17 kat artmıştır. Endotelyal adezyon moleküllerinin AF olgularında atriyal thrombüs gelişim sürecinde önemli rolleri olabilir. Biz bu çalışmada AF hastalarında plazma VCAM-1 (vascular cell adhesion molecule-1 ) ve ICAM-1 (intercellular adhesion molecule-1 ) düzeylerini araştırmayı amaçladık. Hem VAF hem de NVAF hastaları çalışmaya dahil edildi. Kontrol grubuna anjiyografik olarak koroner damarları normal ve kalp ritmi sinüs olan bireyler alındı. Çalışma grubuna 45?i kontrol (ortalama yaş: 51±8, %36 erkek) ve 44?ü AF hastası (ortalama yaş: 62±10, %34 erkek) olmak üzere toplam 89 kişi alındı. İki grup arasında cinsiyet dağılımı benzer (p=0.885) ancak yaş AF grubunda kontrol grubunna göre belirgin olarak daha yüksekti (p
- Published
- 2010
31. Serum oxidized low-density lipoprotein level as a marker of oxidative stress in patients undergoing hyperbaric oxygen therapy.
- Author
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Keskin, Kudret, Kilci, Hakan, Aksan, Gökhan, Çetinkal, Gökhan, Yıldız, Süleyman Sezai, Türk, Füsun Kocaman, and Bingöl, Gülsüm
- Abstract
Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
32. Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease.
- Author
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Bekar, Lütfü, Katar, Muzaffer, Yetim, Mücahit, Çelik, Oğuzhan, Kilci, Hakan, and Önalan, Orhan
- Abstract
Copyright of Archives of the Turkish Society of Cardiology / Türk Kardiyoloji Derneği Arşivi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2016
- Full Text
- View/download PDF
33. Assesment of Right Ventricular Diastolic Function in Chronic Obstructive Lung Disease
- Author
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Yemenici, Hasibe, primary, Yilmaz, Ayse, additional, Kilci, Hakan, additional, Ceyhan, Koksal, additional, Etikan, Ilker, additional, Doruk, Sibel, additional, Onalan, Orhan, additional, and Inonu, Handan, additional
- Published
- 2013
- Full Text
- View/download PDF
34. Successful percutaneous coronary angioplasty in a patient with anomalous origin of the right coronary artery from the left anterior descending artery
- Author
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Ocal, Arslan, Kilci, Hakan, Altunkas, Fatih, and Tumuklu, Mustafa M.
- Published
- 2008
- Full Text
- View/download PDF
35. Assesment of Right Ventricular Diastolic Function in Chronic Obstructive Lung Disease.
- Author
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Yemenici, Hasibe, Yılmaz, Ayşe, Kilci, Hakan, Ceyhan, Köksal, Etikan, İlker, Doruk, Sibel, Önalan, Orhan, İnönü, Handan, Çelikel, Serhat, and Seyfikli, Zehra
- Abstract
Objective: Chronic obstructive lung disease (COPD) is a systemic disease characterised by airflow limitation that is not fully reversible. Right ventricular diastolic function (rvdf) was investigated in COPD.Material and Methods: Study groups consisted of 40 patients with COPD and 24 healthy controls. All subjects performed respiratory function test and doppler echocardiography.Results: There was no statistical difference between patient and control groups with respect to tricuspid annular systolic velocity (S), tricuspid annulus early diastolic filling velocity (E)and tricuspid annulus late diastolic velocity (A) (p>0.05). ForE/A ratio and İVRT, there was a statistical difference between groups (p=0.05, p=0.0001). There was a positive correlation between FEV
1 and E/A ratio (r=0.409, p=0.009). There was no statistically significant correlation between other parameters of Echocardiography (Echo), RFT and arterial blood gas (ABG)analysis comparisons. Decrease in E and E/A ratio in COPD whose SatO2 ≤% 90 was statistically significant compared to patients with SatO2 >%90 (p=0.002). Decreases in E and E/A rates were significant between COPD cases with PH (pulmonary artery pressure PABsis >30 mmHg), and those without PH (p=0.016, p=0.01). There was no statistically significant correlation between PABsis and FEV1 and FEV1 /FVC. There was a negative correlation between PABsis and pO2 , and positive correlation between PABsis and pCO2 (p=0.006, p=0.029). There was a positive correlation between FEV1 , pO2 and satO2 (p=0.018, p=0.001).Conclusion: As a result, we concluded that, in order to evaluate right ventricular functions in COPD cases, we must not only consider systolic functions but also examining the diastolic functions is important. Doppler-Echo proved to be favorable in evaluating vdf in all COPD patients. (Turk Toraks Derg 2012; 13: 152-7) [ABSTRACT FROM AUTHOR]- Published
- 2012
- Full Text
- View/download PDF
36. Reply to the Letter to the Editor Entitled "Which Comes First in Contrast-Induced Nephropathy? Inflammation or Thrombus Formation?".
- Author
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Sigirci, Serhat, Keskin, Kudret, Yildiz, Suleyman Sezai, Cetinkal, Gokhan, Gurdal, Ahmet, Kilci, Hakan, Tezcan, Mehmet, and Kilickesmez, Kadriye Orta
- Subjects
INFLAMMATION ,KIDNEY diseases ,THROMBOSIS ,CONTRAST media - Published
- 2020
- Full Text
- View/download PDF
37. Evaluation of the Atherogenic Index of Plasma to Predict All-Cause Mortality in Elderly With Acute Coronary Syndrome: A Long-Term Follow-Up.
- Author
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Ser, Özgür Selim, Keskin, Kudret, Çetinkal, Gökhan, Balaban Kocaş, Betül, Kilci, Hakan, Kalender, Erol, Dolap, Furkan, Celbiş Geçit, Tümay, Kocaş, Cüneyt, and Kılıçkesmez, Kadriye
- Abstract
The Atherogenic Index of Plasma (AIP) is associated with coronary artery disease (CAD) and acute coronary syndrome (ACS), but the relationship between AIP and ACS in elderly patients remains unclear. We investigated the prognostic capability of AIP for in-hospital and long-term mortality in elderly patients with ACS undergoing coronary angiography (CA). We analyzed 627 patients with ACS over 75 years of age who were admitted to our clinic between April 2015 and December 2022 and underwent CA. The primary clinical endpoints were in-hospital, 30-day, 1-year, and long-term mortality. The median follow-up time was 27 months. AIP was defined as log (triglyceride/high-density lipoprotein cholesterol). In-hospital mortality rates for patients with AIP ≤.1 and AIP >.1 were 4.7% and 17.6% (
P < .001), 30-day mortality rates were 8.7% and 32.2% (P = .01), 1-year mortality rates were 12.1% and 45.1% (P < .001), and long-term mortality rates were 47.3% and 67.5% (P < .001), respectively. Multivariate Cox regression analysis revealed AIP, age, left ventricle ejection fraction (LVEF), admission creatinine, and Killip ≥2 as independent predictors for long-term mortality. AIP can predict in-hospital and long-time all-cause mortality in elderly patients with ACS undergoing CA. Age, LVEF, admission creatinine, and Killip ≥2 are additional factors that predict long-term all-cause mortality. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
38. PREVALENCE AND ASSOCIATION OF FRAGMENTED QRS WITH VENTRICULAR ARRHYTHMIAS IN HYPERTENSIVE PATIENTS
- Author
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Onalan, Orhan, Bekar, Lutfi, Ceyhan, Koksal, Kadi, Hasan, Kilci, Hakan, Koc, Fatih, and Celik, Atac
- Published
- 2011
- Full Text
- View/download PDF
39. Comparison of Sequential POT-Side-POT and Kissing Balloon Techniquesin Patientswith Coronary Bifurcation Lesions Treatedwith Single-Stent Strategy; Which One is Simple and Safe? Propensity Score Analysis.
- Author
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Çetinkal G, Balaban Koçaş B, Keskin K, Kilci H, Ser ÖS, and Kılıçkesmez K
- Subjects
- Constriction, Pathologic epidemiology, Humans, Propensity Score, Retrospective Studies, Stents, Angioplasty, Balloon, Coronary adverse effects, Angioplasty, Balloon, Coronary methods, Coronary Artery Disease surgery
- Abstract
Background: It is unknown whether the novel POT-side-POT technique is more useful than the commonly preferred kissing balloon inflation in patients with non-complex coro- nary bifurcation lesions treated with a single-stent strategy. The aim of this study was to compare the efficacy of POT-side-POT and kissing balloon inflation techniques in one- stent strategy for non-complex coronary bifurcation lesions., Methods: In this study, 283 patients were retrospectively analyzed (POT-side-POT group, n = 149; KBI group, n = 134). Primary endpoints of the study were defined as follows: in- hospital and 30-day mortality, contrast-induced acute kidney injury, stent thrombosis, side branch dissection, and need for side-branch stenting. Characteristics of patients at baseline were balanced by using propensity score inverse probability weighting., Results: Procedure time (minute, 30.6 ± 8.5 vs. 34.3 ± 11.6; P = .003) and contrast volume (milliliter, 153.7 ± 42.4 vs. 171.1 ± 58.2; P = .004) were significantly lower in POT-side-POT group. Besides, side branch residual stenosis and number of patients with >50% side branch residual stenosis remained significantly higher in POT-side-POT group both in general and true bifurcation subgroup analysis (20.3 ± 19.8% vs. 16.5 ± 16.4%, P=.022; 11.9% vs. 5.7%, P = .013 and 24.1 ± 23.2% vs. 18.8 ± 18.7%, P = .033; 17.6% vs. 6.6%, P = .005; respectively). Combined clinical adverse outcomes were similar between groups. Side branch dissection (10.2% vs. 20.1%, P = .001) and need for side branch stenting (12.6% vs. 19%, P=.040) reached statistically significance in kissing balloon inflation group after adjustment., Conclusion: POT-side-POT may be a simple and safe technique with a shorter procedure time and lower incidence of adverse clinical events in non-complex coronary bifurcationlesions treated with single-stent strategy.
- Published
- 2022
- Full Text
- View/download PDF
40. The Association between Chronic Use of Renin-Angiotensin-Aldosterone System Blockers and in-Hospital Adverse Events among COVID-19 Patients with Hypertension.
- Author
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Cetinkal G, Kocas BB, Ser OS, Kilci H, Yildiz SS, Ozcan SN, Verdi Y, Altinay M, and Kilickesmez K
- Abstract
Objectives: The effects of chronic renin-angiotensin-aldosterone system (RAAS) blockers usage on adverse outcomes and disease severity remain uncertain in COVID-19 patients with hypertension. In this study, we aimed to determine the relationship between chronic use of RAAS inhibitors and in-hospital adverse events among hypertensive patients hospitalized with COVID-19., Methods: In this retrospective single-center study, we enrolled 349 consecutive hypertensive patients diagnosed with COVID-19 infection. All patients were chronically on angiotensin-converting enzyme inhibitors (ACEI)/ angiotensin II receptor blockers (ARB) or other antihypertensive therapies before hospital admission. Adverse clinical events were defined as in-hospital mortality, admission to intensive care unit, need for high-flow oxygen and intubation., Results: Patients were categorized into two groups according to the type of antihypertensive therapy. (ACEI/ARBs users, N=201; ACEI/ARB nonusers, N=148) There was no statistically significant difference between ACEI/ARBs users and ACEI/ARBs nonusers concerning adverse clinical events, such as in-hospital mortality (29 (14.4%) vs. 20 (13.5%), p=0.81), ICU admission (45(22.4%) vs. 27 (18.2%), p=0.34), need for high-flow oxygen (97 (48.3%) vs. 68 (45.9%), p=0.67) and need for intubation (32(15.9%) vs. 23(15.5%), p=0.92), respectively. Also, the severity of infection did not differ among groups. The logistic regression multivariate analysis showed that age, neutrophil-lymphocyte ratio, procalcitonin and ferritin levels were independent predictors of in-hospital mortality., Conclusion: Our results suggest that chronic use of ACEI/ARBs did not increase in-hospital adverse outcomes of hypertensive patients hospitalized with COVID-19. Although the recent data are contradictory, chronic ACEI/ARB therapy is not recommended to be discontinued in hypertensive patients during their hospitalization for COVID-19., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2020 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2020
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41. The Association of Plasma Apelin Levels with Plaque Vulnerability.
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Keskin K, Yıldız SS, Çetinkal G, Kilci H, Çalışkan N, Keskin EB, and Kılıçkesmez KO
- Abstract
Objectives: Apelin is a recently discovered peptide that is expressed in many tissues particularly in the cardiovascular system and exerts several actions, most of which are vasodilatory and positive inotropic effects. Based on this, an apelin deficiency is believed to play a significant role in the development of hypertension and heart failure. However, the association of apelin with the pathogenesis of atherosclerosis and especially plaque vulnerability remains unestablished. Thus, to contribute to the literature, in this study, we sought to determine the association of apelin concerning plaque vulnerability in the setting of the acute coronary syndrome., Methods: In this study, we prospectively enrolled a total of 80 patients; 40 with acute coronary syndrome and 40 patients with stable chronic ischemic heart disease. Plasma apelin levels were measured in all patients along with other routine biochemical parameters, and all patients underwent a transthoracic echocardiographic examination., Results: Plasma apelin levels were significantly lower in patients with the acute coronary syndrome (221.2±66.7 vs 254.3±77.9 p=0.04). However, there was no correlation between plasma apelin levels and serum inflammatory markers or coronary artery disease severity., Conclusion: Low plasma apelin levels may create a tendency towards vulnerable plaque and acute coronary syndrome., Competing Interests: Conflict of interest: None declared., (Copyright: © 2019 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2019
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42. In-hospital Outcomes of Patients with ST-segment Elevation Myocardial Infarction who were Intubated before Primary Percutaneous Intervention: Experience of a tertiary center.
- Author
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Yıldız SS, Sığırcı S, Gürdal A, Keskin K, Kilci H, Doğan GM, Hamit T, and Kılıçkesmez K
- Abstract
Objectives: ST-segment elevation myocardial infarction (STEMI) complicated by respiratory failure is associated with a greater number of in-hospital and out-of-hospital adverse cardiovascular events (CVEs). The aim of this study was to analyze in-hospital outcomes and the factors affecting the outcomes of intubated patients diagnosed with STEMI who underwent primary percutaneous coronary intervention (pPCI) at a single tertiary care center., Methods: The data of 592 patients diagnosed with acute STEMI who were admitted to the emergency department between May 2017 and January 2019 and subsequently underwent pPCI were retrospectively reviewed. Cardiovascular risk factors as well as biochemical and angiographic characteristics of patients who were intubated in the emergency room or ambulance due to cardiac arrest and those who were not intubated were compared. Adverse CVEs were defined as in-hospital death, cerebrovascular stroke, and acute stent thrombosis., Results: A total of 60 patients (70% male; mean age: 63.6±14.0 years) who were intubated and 532 non-intubated patients (81% male; mean age: 60.2±12.1 years) were included in the study. The angiographic features of the 2 groups were similar. An adverse CVE was experienced by 43.3% of the intubated patients and 3.6% of the non-intubated patients. Multivariate analysis indicated that age (odds ratio [OR]: 1.065; p<0.001), serum lactate level (OR: 1.308; p<0.001), and left ventricle ejection fraction (OR: 0.946; p<0.001) were independent predictors of in-hospital adverse CVE in the intubated patient group., Conclusion: The results of this single-center study showed that 1 in 10 patients hospitalized with STEMI were intubated, and approximately 4 in 10 intubated STEMI patients had an in-hospital CVE., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2019 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2019
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43. The Value of CHA 2 DS 2 VASC Score in Predicting All-Cause Mortality in Patients with ST-Segment Elevation Myocardial Infarction Who Have Undergone Primary Percutaneous Coronary Intervention.
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Keskin K, Sezai Yıldız S, Çetinkal G, Aksan G, Kilci H, Çetin Ş, Sığırcı S, and Kılıçkesmez K
- Abstract
Background: Acute coronary syndrome is the most common cause of cardiac morbidity and death. Various scoring systems have been developed in order to identify patients who are at risk for adverse outcome and may benefit from more aggressive and effective therapies., Objectives: This study was designed to evaluate the CHA
2 DS2 VASC score as a predictor of mortality inpatients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (p-PCI)., Methods: We evaluated 300 patients diagnosed with ST-elevation myocardial infarction who underwent p-PCI and calculated their CHA2 DS2 VASC scores. According to their CHA2 DS2 VASC scores, patients were divided into three groups. Group 1: 0-1 points (n = 101), Group 2: 2-3 points (n = 129), and Group 3: 4-9 points (n = 70). The mean, median and minimum duration of follow-up were 21.7 ± 9.4, 21, and 12 months, respectively. All-cause mortality was defined as the primary endpoint of the study., Results: All-cause mortality was 4% in Group 1, 8.5% in Group 2 and 27.1% in Group 3 respectively. Kaplan-Meier analysis showed that Group 3 (CHA2 DS2 VASC ≥ 4) had a significantly higher incidence of death [p (log-rank) < 0.001]. In ROC analysis, AUC values for in hospital, 12-month and long-term mortality were 0.88 (0.77-0.99 95% CI), 0.82 (0.73-0.92 95% CI) and 0.79 (0.69-0.88 95% CI), respectively., Conclusions: CHA2 DS2 VASC score can be used for predicting both in-hospital, 12-month and long-term mortality in patients with STEMI who have undergone p-PCI.- Published
- 2017
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44. Serum oxidized low-density lipoprotein level as a marker of oxidative stress in patients undergoing hyperbaric oxygen therapy.
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Keskin K, Kilci H, Aksan G, Çetinkal G, Yıldız SS, Kocaman Türk F, and Bingöl G
- Subjects
- Adult, Aged, Aged, 80 and over, Blindness blood, Blindness therapy, Cholesterol blood, Female, Hearing Loss, Sudden blood, Hearing Loss, Sudden therapy, Humans, Lipoproteins, LDL metabolism, Male, Middle Aged, Oxidation-Reduction, Peripheral Arterial Disease blood, Peripheral Arterial Disease therapy, Prospective Studies, Triglycerides blood, Varicose Ulcer blood, Varicose Ulcer therapy, Young Adult, Hyperbaric Oxygenation, Lipoproteins, LDL blood, Oxidative Stress
- Abstract
Objective: Oxidative stress (OS) is involved in the pathogenesis of atherosclerosis. Hyperbaric oxygen therapy (HBOT), in which 100% oxygen is inhaled under hyperbaric pressure, may create OS. Therefore, the aim of this research was to measure the serum oxidized low-density lipoprotein (oxLDL) level in patients undergoing HBOT., Methods: Twenty-nine patients who underwent HBOT to treat various diseases were enrolled in this study. The serum oxLDL level was measured at the beginning of the first and after the 10th therapy session., Results: There was no significant difference between the oxLDL level of patients before and after HBOT (4.96±0.1 vs. 4.94±0.1 U/mL; p=0.36)., Conclusion: HBOT seems to be safe in terms of oxLDL production up to 10 sessions. However, further large-scale studies investigating longer duration of HBOT treatment are required to understand the role of OS.
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- 2017
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45. Fragmented QRS complexes are a marker of myocardial fibrosis in hypertensive heart disease.
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Bekar L, Katar M, Yetim M, Çelik O, Kilci H, and Önalan O
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- Biomarkers blood, Electrocardiography, Female, Fibrosis blood, Fibrosis diagnosis, Fibrosis physiopathology, Humans, Hypertension, Male, Middle Aged, ROC Curve, Cardiomyopathies blood, Cardiomyopathies diagnosis, Cardiomyopathies physiopathology, Peptide Fragments blood, Procollagen blood
- Abstract
Objective: Carboxy-terminal propeptide of type 1 procollagen (PICP) is a marker of extracellular collagen synthesis. Fragmented QRS (fQRS) on a 12-lead electrocardiogram (ECG) has been demonstrated as a marker of myocardial fibrosis. The present objective was to investigate the association between serum PICP concentration and presence of fQRS on ECG in hypertensive patients., Methods: Consecutive patients with previously or newly diagnosed hypertension were included. fQRS was defined as the presence of additional R-wave (R'), or notching of R- or S-waves, or the presence of fragmentation in 2 contiguous ECG leads. Serum PICP levels were measured by ELISA method., Results: The study group consisted of 90 hypertensive patients (74% females, with a mean age of 54.7±8.5 years). Of these patients, 47 (52.2%) had fQRS on ECG. Age (p=0.121) and gender distribution (p=0.625) were similar in patients with or without fQRS. Receiver operating characteristic curve analysis yielded a strong predictive ability of PICP levels for the presence of fQRS (area under the curve: 0.850; 95% CI: 0.772-0.929; p<0.0001). In multivariate logistic regression analysis, PICP levels were strongly and independently associated with the presence of fQRS (OR: 1.938; 95% CI: 1.398-2.688)., Conclusion: Serum PICP level is a strong and independent predictor of fQRS. Discriminative performance of serum PICP levels for the presence of fQRS is high. The present results are the first to demonstrate that fQRS may indicate myocardial fibrosis in patients with hypertension.
- Published
- 2016
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