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Your search keyword '"Kolb, H. C."' showing total 31 results
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31 results on '"Kolb, H. C."'

2. ChemInform Abstract: Total Synthesis of the Anthelmintic Macrolide Avermectin B1a.

Author

LEY, S. V., primary, ARMSTRONG, A., additional, DIEZ-MARTIN, D., additional, FORD, M. J., additional, GRICE, P., additional, KNIGHT, J. G., additional, KOLB, H. C., additional, MADIN, A., additional, MARBY, C. A., additional, MUKHERJEE, S., additional, SHAW, A. N., additional, SLAWIN, A. M. Z., additional, VILE, S., additional, WHITE, A. D., additional, WILLIAMS, D. J., additional, and WOODS, M., additional

Published
2010
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21. TOTAL SYNTHESIS OF THE ANTHELMINTIC MACROLIDE AVERMECTIN B1A

Author

Ley, S. V., Anthony Robert Armstrong, Diezmartin, D., Ford, M. J., Grice, P., Knight, J. G., Kolb, H. C., Madin, A., Marby, C. A., Mukherjee, S., Shaw, A. N., Alexandra Slawin, Vile, S., White, A. D., Williams, D. J., and Woods, M.

29. ChemInform Abstract: Exploration of β‐Turn Scaffolding Motifs as Components of Sialyl LexMimetics and Their Relevance to P‐Selectin.

Author

HANESSIAN, S., HUYNH, H. K., REDDY, G. V., MCNAUGHTON‐SMITH, G., ERNST, B., KOLB, H. C., MAGNANI, J., and SWEELEY, C.

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Published
1999
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30. Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.

Author

Hanessian S, Huynh HK, Reddy GV, McNaughton-Smith G, Ernst B, Kolb HC, Magnani J, and Sweeley C

Subjects
Binding, Competitive, Carbohydrate Conformation, Carbohydrate Sequence, E-Selectin metabolism, Indolizines chemistry, Molecular Sequence Data, Oligosaccharides chemistry, Sialyl Lewis X Antigen, Structure-Activity Relationship, Substrate Specificity, beta-Lactams chemistry, Indolizines chemical synthesis, Indolizines metabolism, Oligosaccharides chemical synthesis, Oligosaccharides metabolism, P-Selectin metabolism, beta-Lactams chemical synthesis, beta-Lactams metabolism
Abstract

Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.

Published
1998
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31. Sialyl Lewis(x) (sLe(x)) and an sLe(x) mimetic, CGP69669A, disrupt E-selectin-dependent leukocyte rolling in vivo.

Author

Norman KE, Anderson GP, Kolb HC, Ley K, and Ernst B

Subjects
Animals, Leukocytes physiology, Ligands, Male, Mice, Mice, Inbred C57BL, Oligosaccharides agonists, Sialyl Lewis X Antigen, Cell Movement drug effects, E-Selectin physiology, Leukocytes cytology, Oligosaccharides pharmacology
Abstract

Leukocyte rolling is the earliest observable even in their recruitment from the circulation to inflamed tissue. This rolling is mediated largely by interaction between the selectin family of adhesion molecules and their glycosylated ligands. Although the nature of these ligands and their interaction with the selectins is not fully understood, it is accepted that expression of fucosylated sialylated glycans such as sialyl Lewis(x) (sLe(x)) is required for function. Despite findings that sLe(x) inhibits binding of leukocytes to E-selectin in vitro, and has beneficial effects in inflammatory disease models, inhibition of E-selectin-dependent leukocyte rolling in vivo has not been described. Functional overlap between the selectins has been noted and reduction of rolling by E-selectin antibodies only occurs if P-selectin is absent or blocked. We demonstrate that leukocyte rolling velocity in tumor necrosis factor alpha (TNF alpha)-stimulated mouse cremaster is increased following treatment with either sLe(x) or the sLe(x)-mimetic CGP69669A and that rolling is dramatically reduced if CGP69669A is applied in the presence of anti-P-selectin antibody. These effects are characteristic of E-selectin antagonism. In contrast, surgically stimulated (L- or P-selectin-dependent) rolling is unaffected by either sLe(x) or CGP69669A. Our data demonstrate that CGP69669A is an effective and selective antagonist of E-selectin in vivo.

Published
1998

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