30 results on '"Kool, D.R."'
Search Results
2. A history of loss of consciousness or post-traumatic amnesia in minor head injury: 'conditio sine qua non' or one of the risk factors?
- Author
-
Smits, M., Hunink, M.G.M., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, D.R., Hofman, P.A.M., Twijnstra, A., de Haan, G.G., Tanghe, H.L.J., and Dippel, D.W.J.
- Subjects
Loss of consciousness -- Risk factors ,Head injuries -- Complications and side effects ,Head injuries -- Care and treatment ,Amnesia -- Risk factors ,Amnesia -- Diagnosis ,Health ,Psychology and mental health - Published
- 2007
3. High D-dimer levels increase the likelihood of pulmonary embolism
- Author
-
Tick, L.W., Nijkeuter, M., Kramer, M.H.W., Hovens, M.M., Buller, H.R., Leebeek, F.W., Huisman, M.V., Halkes, C.J., Heggelman, B.G., Nix, M., Sohne, M., Bresser, P.J., Kool, D.R., Phoa, S.S., Rekke, B., Kaasjager, K.A., Kwakkel-van Erp, J.M., Grandjean, H.M., Kesselring, F.O.H.W., Mol, J.J., Ullmann, E.F., Guldener, C. van, Mijnsbergen, J.Y., Sturm, M.F., Swart, C. de, Kuijer, P.M., Schrama, J.G., Velde, A. van de, Huisman, P.M., Eerden, M.M. van der, Janssen, P.J., Jansen, R., Lobatto, S., Compier, E.A., Eikenboom, H.C., Roos, A. de, Belle, A. van, Prins, M.H., Snoep, G., Korte, H. de, Kos, C.B., Laterveer, L., Veldhuizen, W.C. van, Kamphuizen, P.W., Bredie, S.J.H., Die, C.E. van, Heijdra, Y.F., Lenders, J.W.M., Kruip, M.J., Jie, K.S., Kars, A.H., Meiracker, A.H. van den, Pattynama, P.M., Borst, J.M. de, Houten, A.A. van, Teng, H.T., ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, and Hematology
- Subjects
medicine.medical_specialty ,Health aging / healthy living [IGMD 5] ,Vascular medicine and diabetes [UMCN 2.2] ,Malignancy ,Sensitivity and Specificity ,Fibrin Fibrinogen Degradation Products ,Internal medicine ,D-dimer ,Internal Medicine ,medicine ,Humans ,In patient ,Cardiovascular diseases [NCEBP 14] ,business.industry ,Vascular disease ,Respiratory disease ,Middle Aged ,medicine.disease ,Surgery ,Pulmonary embolism ,Pathogenesis and modulation of inflammation [N4i 1] ,Management strategy ,Treatment Outcome ,Cardiology ,Female ,business ,Pulmonary Embolism ,Venous thromboembolism ,Tomography, Spiral Computed ,Algorithms ,Biomarkers - Abstract
Contains fulltext : 70029.pdf (Publisher’s version ) (Closed access) Objective. To determine the utility of high quantitative D-dimer levels in the diagnosis of pulmonary embolism. Methods. D-dimer testing was performed in consecutive patients with suspected pulmonary embolism. We included patients with suspected pulmonary embolism with a high risk for venous thromboembolism, i.e. hospitalized patients, patients older than 80 years, with malignancy or previous surgery. Presence of pulmonary embolism was based on a diagnostic management strategy using a clinical decision rule (CDR), D-dimer testing and computed tomography. Results. A total of 1515 patients were included with an overall pulmonary embolism prevalence of 21%. The pulmonary embolism prevalence was strongly associated with the height of the D-dimer level, and increased fourfold with D-dimer levels greater than 4000 ng mL(-1) compared to levels between 500 and 1000 ng mL(-1). Patients with D-dimer levels higher than 2000 ng mL(-1) and an unlikely CDR had a pulmonary embolism prevalence of 36%. This prevalence is comparable to the pulmonary embolism likely CDR group. When D-dimer levels were above 4000 ng mL(-1), the observed pulmonary embolism prevalence was very high, independent of CDR score. Conclusion. Strongly elevated D-dimer levels substantially increase the likelihood of pulmonary embolism. Whether this should translate into more intensive diagnostic and therapeutic measures in patients with high D-dimer levels irrespective of CDR remains to be studied.
- Published
- 2008
- Full Text
- View/download PDF
4. Is a pelvic fracture a predictor for thoracolumbar spine fractures after blunt trauma?
- Author
-
Pouw, M.H., Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Vugt, A.B. van, and Edwards, M.J.R.
- Subjects
musculoskeletal diseases ,Evaluation of complex medical interventions [NCEBP 2] ,Aetiology, screening and detection [ONCOL 5] ,musculoskeletal system - Abstract
Contains fulltext : 80078.pdf (Publisher’s version ) (Closed access) BACKGROUND: Discussion still remains which polytraumatized patients require radiologic thoracolumbar spine (TL spine) screening. The purpose of this study is to determine whether pelvic fractures are associated with TL spine fractures after a blunt trauma. Additionally, the sensitivity of conventional TL spine radiographs and pelvic radiographs (PXRs) is evaluated. METHODS: We prospectively studied 721 consecutive patients who had sustained a high-energy blunt trauma. The diagnostic workup in these patients included routine conventional radiographs of the pelvis and TL spine followed by a computed tomography (CT) analysis. All patients with pelvic fractures and TL spine fractures identified on conventional radiographs and CT were analyzed. A relative risk (RR) was calculated for the association between pelvic fractures and TL spine fractures. The sensitivity for conventional TL spine radiographs and PXRs in identifying fractures was calculated. RESULTS: Of the 721 patients studied, 620 were included in our diagnostic high-energy trauma protocol. Of these 620 included patients, 86 (14%) suffered a pelvic fracture and 126 (20%) suffered a TL spine fracture. Thirty-three patients (5%) suffered both a pelvic fracture and a TL spine fracture. The RR for a TL spine fracture in the presence of a pelvic fracture identified on PXR is 2.14 (95% confidence interval, 1.54-2.98) and identified on CT this RR is 2.20 (95% confidence interval, 1.59-3.05). However, this association diminishes to a nonsignificant level when the transverse process and spinous process fractures are excluded. Overall sensitivity for conventional TL spine radiographs and PXRs is 22% and 69%, respectively. CONCLUSION: Our data suggest that a pelvic fracture is not a predictor for clinically relevant TL spine fractures. Furthermore, our data confirm the superior sensitivity of CT for detecting TL spine injury and pelvic fractures.
- Published
- 2009
5. Advanced Trauma Life Support. ABCDE from a radiological point of view
- Author
-
Kool, D.R. and Blickman, J.G.
- Subjects
hemic and lymphatic diseases ,Functional Imaging [UMCN 1.1] ,Functional imaging [CTR 1] - Abstract
Contains fulltext : 52332.pdf (Publisher’s version ) (Closed access) Accidents are the primary cause of death in patients aged 45 years or younger. In many countries, Advanced Trauma Life Support(R) (ATLS) is the foundation on which trauma care is based. We will summarize the principles and the radiological aspects of the ATLS, and we will discuss discrepancies with day to day practice and the radiological literature. Because the ATLS is neither thorough nor up-to-date concerning several parts of radiology in trauma, it should not be adopted without serious attention to defining the indications and limitations pertaining to diagnostic imaging.
- Published
- 2007
6. Thoracoabdominal computed tomography in trauma patients: a cost-consequences analysis
- Author
-
Vugt, R. van, Kool, D.R., Brink, M., Dekker, H.M., Deunk, J., Edwards, M.J.R., Vugt, R. van, Kool, D.R., Brink, M., Dekker, H.M., Deunk, J., and Edwards, M.J.R.
- Abstract
Contains fulltext : 139472.pdf (publisher's version ) (Open Access), BACKGROUND: CT is increasingly used during the initial evaluation of blunt trauma patients. In this era of increasing cost-awareness, the pros and cons of CT have to be assessed. OBJECTIVES: This study was performed to evaluate cost-consequences of different diagnostic algorithms that use thoracoabdominal CT in primary evaluation of adult patients with high-energy blunt trauma. MATERIALS AND METHODS: We compared three different algorithms in which CT was applied as an immediate diagnostic tool (rush CT), a diagnostic tool after limited conventional work-up (routine CT), and a selective tool (selective CT). Probabilities of detecting and missing clinically relevant injuries were retrospectively derived. We collected data on radiation exposure and performed a micro-cost analysis on a reference case-based approach. RESULTS: Both rush and routine CT detected all thoracoabdominal injuries in 99.1% of the patients during primary evaluation (n = 1040). Selective CT missed one or more diagnoses in 11% of the patients in which a change of treatment was necessary in 4.8%. Rush CT algorithm costed euro 2676 (US$ 3660) per patient with a mean radiation dose of 26.40 mSv per patient. Routine CT costed euro 2815 (US$ 3850) and resulted in the same radiation exposure. Selective CT resulted in less radiation dose (23.23 mSv) and costed euro 2771 (US$ 3790). CONCLUSIONS: Rush CT seems to result in the least costs and is comparable in terms of radiation dose exposure and diagnostic certainty with routine CT after a limited conventional work-up. However, selective CT results in less radiation dose exposure but a slightly higher cost and less certainty.
- Published
- 2014
7. An evidence based blunt trauma protocol
- Author
-
Vugt, R. van, Kool, D.R., Lubeek, S.F.K., Dekker, H.M., Brink, M., Deunk, J., Edwards, M.J.R., Vugt, R. van, Kool, D.R., Lubeek, S.F.K., Dekker, H.M., Brink, M., Deunk, J., and Edwards, M.J.R.
- Abstract
Item does not contain fulltext, OBJECTIVE: Currently CT is rapidly implemented in the evaluation of trauma patients. In anticipation of a large international multicentre trial, this study's aim was to evaluate the clinical feasibility of a new diagnostic protocol, used for the primary radiological evaluation in adult blunt high-energy trauma patients, especially for the use of CT. METHODS: An evidence-based flow chart was created with criteria based on trauma mechanism, physical examination and laboratory analyses to indicate appropriateness of conventional radiography (CR), sonography and CT of head, cervical spine and trunk. To evaluate this protocol, the authors prospectively included 81 consecutive patients. Collected data included protocol adherence and number and type of performed CR and CT scans. The authors also determined the time needed to perform radiological investigations, adverse events in the CT room and clinically relevant missed injuries after 1-month clinical follow-up. RESULTS: There was 99% adherence to the protocol concerning CT. Seventy-nine patients (98%) received one or more CT scans: 72 (89%) had thoracoabdominal, 78 (96%) cervical spine and 54 (67%) had cranial CT. In 30 patients, one or more CT scans of body regions could be omitted. In 38%, CR was wrongly omitted or performed incorrectly at a variance with the protocol. No major adverse events occurred in the CT room and no clinically relevant injuries were missed. CONCLUSIONS: The authors introduced a diagnostic protocol that seems feasible and safe for the evaluation of adult blunt high-energy trauma patients. Implementation of this protocol has the potential to reduce unnecessary radiological investigations, especially CT scans.
- Published
- 2013
8. Effects on mortality, treatment, and time management as a result of routine use of total body computed tomography in blunt high-energy trauma patients.
- Author
-
Vugt, R. van, Kool, D.R., Deunk, J., Edwards, M.J.R., Vugt, R. van, Kool, D.R., Deunk, J., and Edwards, M.J.R.
- Abstract
1 maart 2012, Item does not contain fulltext, BACKGROUND: Currently, total body computed tomography (TBCT) is rapidly implemented in the evaluation of trauma patients. With this review, we aim to evaluate the clinical implications-mortality, change in treatment, and time management-of the routine use of TBCT in adult blunt high-energy trauma patients compared with a conservative approach with the use of conventional radiography, ultrasound, and selective computed tomography. METHODS: A literature search for original studies on TBCT in blunt high-energy trauma patients was performed. Two independent observers included studies concerning mortality, change of treatment, and/or time management as outcome measures. For each article, relevant data were extracted and analyzed. In addition, the quality according to the Oxford levels of evidence was assessed. RESULTS: From 183 articles initially identified, the observers included nine original studies in consensus. One of three studies described a significant difference in mortality; four described a change of treatment in 2% to 27% of patients because of the use of TBCT. Five studies found a gain in time with the use of immediate routine TBCT. Eight studies scored a level of evidence of 2b and one of 3b. CONCLUSION: Current literature has predominantly suboptimal design to prove terminally that the routine use of TBCT results in improved survival of blunt high-energy trauma patients. TBCT can give a change of treatment and improves time intervals in the emergency department as compared with its selective use.
- Published
- 2012
9. Influence of routine computed tomography on predicted survival from blunt thoracoabdominal trauma
- Author
-
Vugt, R. van, Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Vugt, A.B. van, Edwards, M.J.R., Vugt, R. van, Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Vugt, A.B. van, and Edwards, M.J.R.
- Abstract
Item does not contain fulltext, INTRODUCTION: Many scoring systems have been proposed to predict the survival of trauma patients. This study was performed to evaluate the influence of routine thoracoabdominal computed tomography (CT) on the predicted survival according to the trauma injury severity score (TRISS). PATIENTS AND METHODS: 1,047 patients who had sustained a high-energy blunt trauma over a 3-year period were prospectively included in the study. All patients underwent physical examination, conventional radiography of the chest, thoracolumbar spine and pelvis, abdominal sonography, and routine thoracoabdominal CT. From this group with routine CT, we prospectively defined a selective CT (sub)group for cases with abnormal physical examination and/or conventional radiography and/or sonography. Type and extent of injuries were recorded for both the selective and the routine CT groups. Based on the injuries found by the two different CT algorithms, we calculated the injury severity scores (ISS) and predicted survivals according to the TRISS methodology for the routine and the selective CT algorithms. RESULTS: Based on injuries detected by the selective CT algorithm, the mean ISS was 14.6, resulting in a predicted mortality of 12.5%. Because additional injuries were found by the routine CT algorithm, the mean ISS increased to 16.9, resulting in a predicted mortality of 13.7%. The actual observed mortality was 5.4%. CONCLUSION: Routine thoracoabdominal CT in high-energy blunt trauma patients reveals more injuries than a selective CT algorithm, resulting in a higher ISS. According to the TRISS, this results in higher predicted mortalities. Observed mortality, however, was significantly lower than predicted. The predicted survival according to MTOS seems to underestimate the actual survival when routine CT is used.
- Published
- 2011
10. Minor head injury: CT-based strategies for management--a cost-effectiveness analysis.
- Author
-
Smits, M., Dippel, D.W., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, D.R., Rijssel, D.A. van, Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., Hunink, M.G.M., Smits, M., Dippel, D.W., Nederkoorn, P.J., Dekker, H.M., Vos, P.E., Kool, D.R., Rijssel, D.A. van, Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., and Hunink, M.G.M.
- Abstract
1 februari 2010, Contains fulltext : 88949.pdf (publisher's version ) (Closed access), PURPOSE: To compare the cost-effectiveness of using selective computed tomographic (CT) strategies with that of performing CT in all patients with minor head injury (MHI). MATERIALS AND METHODS: The internal review board approved the study; written informed consent was obtained from all interviewed patients. Five strategies were evaluated, with CT performed in all patients with MHI; selectively according to the New Orleans criteria (NOC), Canadian CT head rule (CCHR), or CT in head injury patients (CHIP) rule; or in no patients. A decision tree was used to analyze short-term costs and effectiveness, and a Markov model was used to analyze long-term costs and effectiveness. n-Way and probabilistic sensitivity analyses and value-of-information (VOI) analysis were performed. Data from the multicenter CHIP Study involving 3181 patients with MHI were used. Outcome measures were first-year and lifetime costs, quality-adjusted life-years, and incremental cost-effectiveness ratios. RESULTS: Study results showed that performing CT selectively according to the CCHR or the CHIP rule could lead to substantial U.S. cost savings ($120 million and $71 million, respectively), and the CCHR was the most cost-effective at reference-case analysis. When the prediction rule had lower than 97% sensitivity for the identification of patients who required neurosurgery, performing CT in all patients was cost-effective. The CHIP rule was most likely to be cost-effective. At VOI analysis, the expected value of perfect information was $7 billion, mainly because of uncertainty about long-term functional outcomes. Conclusion: Selecting patients with MHI for CT renders cost savings and may be cost-effective, provided the sensitivity for the identification of patients who require neurosurgery is extremely high. Uncertainty regarding long-term functional outcomes after MHI justifies the routine use of CT in all patients with these injuries.
- Published
- 2010
11. Criteria for the selective use of chest computed tomography in blunt trauma patients.
- Author
-
Brink, M., Deunk, J., Dekker, H.M., Edwards, M.J.R., Kool, D.R., Vugt, A.B. van, Kuijk, C. van, Blickman, J.G., Brink, M., Deunk, J., Dekker, H.M., Edwards, M.J.R., Kool, D.R., Vugt, A.B. van, Kuijk, C. van, and Blickman, J.G.
- Abstract
1 april 2010, Contains fulltext : 87857.pdf (publisher's version ) (Closed access), PURPOSE: The purpose of this study was to derive parameters that predict which high-energy blunt trauma patients should undergo computed tomography (CT) for detection of chest injury. METHODS: This observational study prospectively included consecutive patients (>or=16 years old) who underwent multidetector CT of the chest after a high-energy mechanism of blunt trauma in one trauma centre. RESULTS: We included 1,047 patients (median age, 37; 70% male), of whom 508 had chest injuries identified by CT. Using logistic regression, we identified nine predictors of chest injury presence on CT (age >or=55 years, abnormal chest physical examination, altered sensorium, abnormal thoracic spine physical examination, abnormal chest conventional radiography (CR), abnormal thoracic spine CR, abnormal pelvic CR or abdominal ultrasound, base excess <-3 mmol/l and haemoglobin <6 mmol/l). Of 855 patients with >or=1 positive predictors, 484 had injury on CT (95% of all 508 patients with injury). Of all 192 patients with no positive predictor, 24 (13%) had chest injury, of whom 4 (2%) had injuries that were considered clinically relevant. CONCLUSION: Omission of CT in patients without any positive predictor could reduce imaging frequency by 18%, while most clinically relevant chest injuries remain adequately detected.
- Published
- 2010
12. Emergency radiology; more than just trauma.
- Author
-
Kool, D.R. and Kool, D.R.
- Abstract
1 april 2010, Item does not contain fulltext
- Published
- 2010
13. Emergency department radiology: reality or luxury? An international comparison.
- Author
-
Kool, D.R., Blickman, J.G., Kool, D.R., and Blickman, J.G.
- Abstract
1 april 2010, Contains fulltext : 88729.pdf (publisher's version ) (Closed access), Changes in society and developments within emergency care affect imaging in the emergency department. It is clear that radiologists have to be pro-active to even survive. High quality service is the goal, and if we are to add value to the diagnostic (and therapeutic) chain of healthcare, sub-specialization is the key, and, although specifically patient-oriented and not organ-based, emergency and trauma imaging is well suited for that. The development of emergency radiology in Europe and the United States is compared with emphasis on how different healthcare systems and medical cultures affect the utilization of Acute Care imaging.
- Published
- 2010
14. The clinical outcome of occult pulmonary contusion on multidetector-row computed tomography in blunt trauma patients.
- Author
-
Deunk, J., Poels, T.C., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, Edwards, M.J.R., Deunk, J., Poels, T.C., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, and Edwards, M.J.R.
- Abstract
1 februari 2010, Contains fulltext : 88962.pdf (publisher's version ) (Closed access), BACKGROUND: Multidetector-row computed tomography (MDCT) is a more sensitive modality as compared with conventional radiography (CR) in detecting pulmonary injuries. MDCT often detects pulmonary contusion that is not visualized by CR, defined as occult pulmonary contusion (OPC). The aim of this study was to investigate whether OPC on MDCT has implications for the outcome in blunt trauma patients. METHODS: We used prospectively collected data from 1,040 adult high-energy blunt trauma patients who were primarily presented at our emergency department and who underwent CR and MDCT of the chest. All patients with pulmonary contusion were identified and divided into two groups: The "CR/computed tomography (CT) group" consisted of patients with pulmonary contusion visible on both CR and MDCT. The "CT-only" group consisted of patients with OPC, visible exclusively on MDCT. The control group consisted of blunt trauma patients without pulmonary contusion. These groups were compared with respect to difference in mortality and other outcome measures. In addition, a multivariate analysis was performed. RESULTS: Two hundred fifty-five patients suffered pulmonary contusion: The CT-only group consisted of 157 and the CR/CT group of 98 patients. The CT-only group did not differ from the control group with respect to mortality rate and other outcome measures. However, compared with the CR/CT group, mortality rate was significantly lower (8% versus 16%, p = 0.039) and most other outcome measures were significantly better in the CT-only group. CONCLUSION: OPC on MDCT is not associated with a worse outcome as compared with patients without pulmonary contusion. OPC has a better outcome as compared with pulmonary contusion visible on both CR and MDCT.
- Published
- 2010
15. Predictors for the selection of patients for abdominal CT after blunt trauma: a proposal for a diagnostic algorithm.
- Author
-
Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, Edwards, M.J.R., Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, and Edwards, M.J.R.
- Abstract
1 maart 2010, Contains fulltext : 89655.pdf (publisher's version ) (Closed access), OBJECTIVE: To select parameters that can predict which patients should receive abdominal computed tomography (CT) after high-energy blunt trauma. SUMMARY BACKGROUND DATA: Abdominal CT accurately detects injuries of the abdomen, pelvis, and lumbar spine, but has important disadvantages. More evidence for an appropriate patient selection for CT is required. METHODS: A prospective observational study was performed on consecutive adult high-energy blunt trauma patients. All patients received primary and secondary surveys according to the advanced trauma life support, sonography (focused assessment with sonography for trauma [FAST]), conventional radiography (CR) of the chest, pelvis, and spine and routine abdominal CT. Parameters from prehospital information, physical examination, laboratory investigations, FAST, and CR were prospectively recorded for all patients. Independent predictors for the presence of > or =1 injuries on abdominal CT were determined using a multivariate logistic regression analysis. RESULTS: A total of 1040 patients were included, 309 had injuries on abdominal CT. Nine parameters were independent predictors for injuries on CT: abnormal CR of the pelvis (odds ratio [OR], 46.8), lumbar spine (OR, 16.2), and chest (OR, 2.37), abnormal FAST (OR, 26.7), abnormalities in physical examination of the abdomen/pelvis (OR, 2.41) or lumbar spine (OR 2.53), base excess <-3 (OR, 2.39), systolic blood pressure <90 mm Hg (OR, 3.81), and long bone fractures (OR, 1.61). The prediction model based on these predictors resulted in a R of 0.60, a sensitivity of 97%, and a specificity of 33%. A diagnostic algorithm was subsequently proposed, which could reduce CT usage with 22% as compared with a routine use. CONCLUSIONS: Based on parameters from physical examination, laboratory, FAST, and CR, we created a prediction model with a high sensitivity to select patients for abdominal CT after blunt trauma. A diagnostic algorithm was proposed.
- Published
- 2010
16. Management of Thyroid Gland Hemorrhage After Blunt Trauma: Case report and Review of Literature
- Author
-
Schipper, E., Kool, D.R., Wobbes, T., Geeraedts, L.M.G., Schipper, E., Kool, D.R., Wobbes, T., and Geeraedts, L.M.G.
- Abstract
Contains fulltext : 79896.pdf (publisher's version ) (Open Access)
- Published
- 2009
17. Routine versus selective multidetector-row computed tomography (MDCT) in blunt trauma patients: level of agreement on the influence of additional findings on management.
- Author
-
Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, Edwards, M.J.R., Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Blickman, J.G., Vugt, A.B. van, and Edwards, M.J.R.
- Abstract
Contains fulltext : 81609.pdf (publisher's version ) (Closed access), INTRODUCTION: This study was performed to determine the agreement between and within surgeons concerning the influence on treatment plan of routine versus selective multidetector-row computed tomography (MDCT) findings in blunt trauma patients. PATIENTS: For this study, 50 patients were randomly selected from a customized database that was originally used to compare a diagnostic algorithm with a selective use of MDCT with an algorithm with routine MDCT of the spine, chest, and abdomen within the same population. In all 50 patients, routine MDCT found additional diagnoses as compared with the selective MDCT algorithm. Of all patients, paper cases were created with detailed information on clinical parameters, findings by physical examination, and radiologic findings. The cases were independently presented to three different trauma surgeons. First, the surgeons were asked for their treatment plan based upon diagnoses found by physical examination, conventional radiography, and selective MDCT alone. Subsequently they were asked for their treatment plan with knowledge of the injuries additionally found by routine MDCT. This procedure was repeated after 3 months. The agreement between and within surgeons was determined for the change of patient management because of additional findings by routine MDCT. RESULTS: The agreement on the influence of routine MDCT findings on patient management between surgeons was moderate ([kappa] = 0.46) in the first procedure and substantial in the second ([kappa] = 0.67). The agreement within surgeons ranged from moderate ([kappa] = 0.60) to excellent ([kappa] = 0.87). CONCLUSION: All surgeons agreed that the traumatic injuries additionally found by routine MDCT, frequently resulted in a change of treatment plan. There was a moderate-to-excellent agreement between and within surgeons that these additional findings resulted in a change of treatment plan.
- Published
- 2009
18. Routine versus selective computed tomography of the abdomen, pelvis, and lumbar spine in blunt trauma: a prospective evaluation.
- Author
-
Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Kuijk, C. van, Blickman, J.G., Vugt, A.B. van, Edwards, M.J.R., Deunk, J., Brink, M., Dekker, H.M., Kool, D.R., Kuijk, C. van, Blickman, J.G., Vugt, A.B. van, and Edwards, M.J.R.
- Abstract
Contains fulltext : 81608.pdf (publisher's version ) (Closed access), BACKGROUND: Discussion still remains whether computed tomography (CT) of the abdomen, pelvis, and lumbar spine should be performed routinely after blunt trauma with high energy impact or only in restricted situations. The purpose of this study was to evaluate the additional value of a routine CT algorithm as compared with a more restricted, selective CT algorithm. MATERIALS: This prospective study consisted of 465 patients that met the inclusion criteria of our high-energy trauma protocol. All patients underwent physical examination, abdominal ultrasound (AUS), and conventional radiography (CR) of the pelvis and lumbar spine and subsequently routine CT of the abdomen, pelvis, and lumbar spine. Before CT, a subgroup of patients with abnormal physical examination or CR or AUS was prospectively defined as the selective CT group. Type and extent of injuries and impact on treatment were recorded for both the routine CT group and the selective CT subgroup. RESULTS: Of all patients, 42 received selective CT of the abdomen, 71 of the pelvis, and 48 of the lumbar spine. Compared with the algorithm with selective CT, routine CT revealed additional traumatic injuries in 15% of the patients in the abdomen, in 2.4% in the pelvis and in 8.2% in the lumbar spine. This resulted in an overall change of treatment in 6.4% (95% confidence interval, 3.7-9.0) of the patients who would not have received CT in a selective CT algorithm. CONCLUSIONS: Compared with an algorithm with selective CT, an algorithm with routine CT finds substantially more clinically relevant diagnoses, even in patients with unsuspicious clinical examination, normal CR, and normal AUS.
- Published
- 2009
19. Added value of routine chest MDCT after blunt trauma: evaluation of additional findings and impact on patient management.
- Author
-
Brink, M., Deunk, J., Dekker, H.M., Kool, D.R., Edwards, M.J.R., Vugt, A.B. van, Blickman, J.G., Brink, M., Deunk, J., Dekker, H.M., Kool, D.R., Edwards, M.J.R., Vugt, A.B. van, and Blickman, J.G.
- Abstract
Contains fulltext : 69546.pdf (publisher's version ) (Closed access), OBJECTIVE: The objective of our study was to evaluate the added value of a low-threshold routine thoracic MDCT algorithm compared with a selective MDCT algorithm in adult blunt trauma patients. SUBJECTS AND METHODS: A prospective cohort study was conducted in 464 consecutive blunt trauma patients who met criteria indicative of severe blunt trauma (66% male; age range, 16-93 years; median injury severity score, 13). After clinical evaluation and conventional radiography of the chest and thoracic spine, all patients underwent routine thoracic MDCT with an IV contrast agent (routine MDCT algorithm). Within this routine MDCT group, a subgroup was prospectively defined with abnormal or inconclusive clinical or conventional radiography evaluation (selective MDCT group). Two investigators determined the type, extent, and clinical impact of additional injuries found on MDCT as compared to conventional radiography for both MDCT groups. RESULTS: Of all 464 patients within the routine MDCT group, 164 patients underwent selective MDCT, which resulted in detection of additional diagnoses compared with conventional radiography in 97 (59%) patients. The routine MDCT algorithm detected additional diagnoses compared with conventional radiography in 201 of 464 patients (43%). Compared with the selective MDCT algorithm, this was an absolute increase of 104 of 464 (22%) extra patients, resulting in a change in patient management in 34 (7%; 95% CI, 5-9.7%), mostly because of additional findings of pulmonary and mediastinal injury. CONCLUSION: Routine MDCT has relatively lower, though still substantial, added diagnostic value compared with selective MDCT of the chest.
- Published
- 2008
20. Outcome after complicated minor head injury.
- Author
-
Smits, M., Hunink, M.G.M., Rijssel, D.A. van, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., Dippel, D.W., Smits, M., Hunink, M.G.M., Rijssel, D.A. van, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., and Dippel, D.W.
- Abstract
Contains fulltext : 71531.pdf (publisher's version ) (Closed access), BACKGROUND AND PURPOSE: Functional outcome in patients with minor head injury with neurocranial traumatic findings on CT is largely unknown. We hypothesized that certain CT findings may be predictive of poor functional outcome. Materials and METHODS: All patients from the CT in Head Injury Patients (CHIP) study with neurocranial traumatic CT findings were included. The CHIP study is a prospective, multicenter study of consecutive patients, > or =16 years of age, presenting within 24 hours of blunt head injury, with a Glasgow Coma Scale (GCS) score of 13-14 or a GCS score of 15 and a risk factor. Primary outcome was functional outcome according to the Glasgow Outcome Scale (GOS). Other outcome measures were the modified Rankin Scale (mRS), the Barthel Index (BI), and number and severity of postconcussive symptoms. The association between CT findings and outcome was assessed by using univariable and multivariable regression analysis. RESULTS: GOS was assessed in 237/312 patients (76%) at an average of 15 months after injury. There was full recovery in 150 patients (63%), moderate disability in 70 (30%), severe disability in 7 (3.0%), and death in 10 (4.2%). Outcome according to the mRS and BI was also favorable in most patients, but 82% of patients had postconcussive symptoms. Evidence of parenchymal damage was the only independent predictor of poor functional outcome (odds ratio = 1.89, P = .022). CONCLUSION: Patients with neurocranial complications after minor head injury generally make a good functional recovery, but postconcussive symptoms may persist. Evidence of parenchymal damage on CT was predictive of poor functional outcome.
- Published
- 2008
21. Arm raising at exposure-controlled multidetector trauma CT of thoracoabdominal region: higher image quality, lower radiation dose.
- Author
-
Brink, M., Lange, F. de, Oostveen, L.J., Dekker, H.M., Kool, D.R., Deunk, J., Edwards, M.J.R., Kuijk, C. van, Kamman, R.L, Blickman, J.G., Brink, M., Lange, F. de, Oostveen, L.J., Dekker, H.M., Kool, D.R., Deunk, J., Edwards, M.J.R., Kuijk, C. van, Kamman, R.L, and Blickman, J.G.
- Abstract
Contains fulltext : 69921.pdf (publisher's version ) (Closed access), PURPOSE: To evaluate the effect of arm position on image quality and effective radiation dose in an automatic exposure-controlled (AEC) multidetector thoracoabdominal computed tomography (CT) protocol in trauma patients. MATERIALS AND METHODS: This retrospective study of the data of 177 trauma patients (117 male; median age, 39 years) was approved by the institutional ethics board, with informed patient consent waived. Patients underwent scanning by using an AEC 16-detector thoracoabdominal CT protocol in which both arms were raised above the shoulder region (standard-position group, 132 patients), one arm was raised and the other was down (one-arm group, 27 patients), or both arms were down (two-arm group, 18 patients). Objective and subjective image quality was assessed. Individual effective radiation dose was calculated from the effective tube current-time product per exposed section. For this purpose, section location-dependent conversion factors were derived by using a CT dosimetry calculator. The effect of arm position on effective dose was quantified by using linear regression analysis with correction for patient volume and attenuation. RESULTS: Compared with the image quality in the standard-position group, the image quality in the one- and two-arm groups was decreased but within acceptable diagnostic limits. The median corrected effective dose in the standard-position group was 18.6 mSv; the dose in the one-arm group was 18% (95% confidence interval: 11%, 25%) higher than this, and that in the two-arm group was 45% (95% confidence interval: 34%, 57%) higher. CONCLUSION: Omitting arm raising results in lower but acceptable image quality and a substantially higher effective radiation dose. Hence, effort should be made to position the arms above the shoulder when scanning trauma patients. Clinical trial registration no. NCT00228111.
- Published
- 2008
22. Minor head injury: guidelines for the use of CT--a multicenter validation study.
- Author
-
Smits, M., Dippel, D.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., Hunink, M.G.M., Smits, M., Dippel, D.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., and Hunink, M.G.M.
- Abstract
Contains fulltext : 51429.pdf (publisher's version ) (Closed access), PURPOSE: To prospectively and externally validate published national and international guidelines for the indications of computed tomography (CT) in patients with a minor head injury. MATERIALS AND METHODS: The study protocol was institutional review board approved. All patients implicitly consented to use of their deidentified data for research purposes. Between February 2002 and August 2004, data were collected in consecutive adult patients with blunt minor head injury (Glasgow Coma Scale score of 13-14 or 15) and a risk factor for neurocranial traumatic complications at presentation at four Dutch university hospitals. Primary outcome was any neurocranial traumatic CT finding. Secondary outcomes were clinically relevant traumatic CT findings and neurosurgical intervention. Sensitivity and specificity of each guideline for all outcomes and the number of patients needed to scan to detect one outcome (ie, the number of patients needed to undergo CT to find one patient with a neurocranial traumatic CT finding, a clinically relevant traumatic CT finding, or a CT finding that required neurosurgical intervention) were estimated. RESULTS: Data were available for 3181 patients. Only the European Federation of Neurological Societies guidelines reached a sensitivity of 100% for all outcomes. Specificity was 0.0%-0.5%. The Dutch guidelines had the lowest sensitivity (76.5%) for neurosurgical interventions. The best specificities for traumatic CT findings and neurosurgical interventions were reached with the criteria proposed by the United Kingdom National Institute for Clinical Excellence (NICE) (46.1% and 43.6%, respectively), albeit at relatively low sensitivities (82.1% and 94.1%, respectively). The number of patients needed to scan ranged from six to 13 for traumatic CT findings and from 79 to 193 for neurosurgical interventions. CONCLUSION: All validated guidelines demonstrated a trade-off between sensitivity and specificity. The lowest number of patients needed to scan
- Published
- 2007
23. Predicting intracranial traumatic findings on computed tomography in patients with minor head injury: the CHIP prediction rule.
- Author
-
Smits, M., Dippel, D.W., Steyerberg, E.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., Hunink, M.G.M., Smits, M., Dippel, D.W., Steyerberg, E.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., and Hunink, M.G.M.
- Abstract
Contains fulltext : 51516.pdf (publisher's version ) (Closed access), BACKGROUND: Prediction rules for patients with minor head injury suggest that the use of computed tomography (CT) may be limited to certain patients at risk for intracranial complications. These rules apply only to patients with a history of loss of consciousness, which is frequently absent. OBJECTIVE: To develop a prediction rule for the use of CT in patients with minor head injury, regardless of the presence or absence of a history of loss of consciousness. DESIGN: Prospective, observational study. SETTING: 4 university hospitals in the Netherlands that participated in the CT in Head Injury Patients (CHIP) study. PATIENTS: Consecutive adult patients with minor head injury (> or =16 years of age) with a Glasgow Coma Scale (GCS) score of 13 to 14 or with a GCS score of 15 and at least 1 risk factor. MEASUREMENTS: Outcomes were any intracranial traumatic CT finding and neurosurgical intervention. The authors performed logistic regression analysis by using variables from existing prediction rules and guidelines, with internal validation by using bootstrapping. RESULTS: 3181 patients were included (February 2002 to August 2004): 243 (7.6%) had intracranial traumatic CT findings and 17 (0.5%) underwent neurosurgical intervention. A detailed prediction rule was developed from which a simple rule was derived. Sensitivity of both rules was 100% for neurosurgical interventions, with an associated specificity of 23% to 30%. For intracranial traumatic CT findings, sensitivity and specificity were 94% to 96% and 25% to 32%, respectively. Potential CT reduction by implementing the prediction rule was 23% to 30%. Internal validation showed slight optimism for the model's performance. LIMITATION: External validation of the prediction model will be required. CONCLUSION: The authors propose the highly sensitive CHIP prediction rule for the selective use of CT in patients with minor head injury with or without loss of consciousness.
- Published
- 2007
24. A history of loss of consciousness or post-traumatic amnesia in minor head injury: 'conditio sine qua non' or one of the risk factors?
- Author
-
Smits, M. (Marion), Twijnstra, A. (Albert), Hofman, P.A.M. (Paul), Haan, G.G. (Gijs) de, Tanghe, H.L.J. (Hervé), Dippel, D.W.J. (Diederik), Hunink, M.G.M. (Myriam), Nederkoorn, P.J. (Paul), Dekker, H.M. (Heleen), Vos, P.E. (Pieter), Kool, D.R. (Digna), Smits, M. (Marion), Twijnstra, A. (Albert), Hofman, P.A.M. (Paul), Haan, G.G. (Gijs) de, Tanghe, H.L.J. (Hervé), Dippel, D.W.J. (Diederik), Hunink, M.G.M. (Myriam), Nederkoorn, P.J. (Paul), Dekker, H.M. (Heleen), Vos, P.E. (Pieter), and Kool, D.R. (Digna)
- Abstract
OBJECTIVE: A history of loss of consciousness (LOC) or post-traumatic amnesia (PTA) is commonly considered a prerequisite for minor head injury (MHI), although neurocranial complications also occur when LOC/PTA are absent, particularly in the presence of other risk factors. The purpose of this study was to evaluate whether known risk factors for complications after MHI in the absence of LOC/PTA have the same predictive value as when LOC/PTA are present. METHODS: A prospective multicentre study was performed in four university hospitals between February 2002 and August 2004 of consecutive blunt head injury patients (> or = 16 years) presenting with a normal level of consciousness and a risk factor. Outcome measures were any neurocranial traumatic CT finding and neurosurgical intervention. Common odds ratios (OR) were estimated for each of the risk factors and tested for homogeneity. RESULTS: 2462 patients were included: 1708 with and 754 without LOC/PTA. Neurocranial traumatic findings on CT were present in 7.5% and were more common when LOC/PTA was present (8.7%). Neurosurgical intervention was required in 0.4%, irrespective of the presence of LOC/PTA. ORs were comparable across the two subgroups (p>0.05), except for clinical evidence of a skull
- Published
- 2007
- Full Text
- View/download PDF
25. An abused five-month-old girl: Hangman's fracture or congenital arch defect?
- Author
-
Rijn, R.R. van, Kool, D.R., Witt-Hamer, P.C. de, Majoie, C.B., Rijn, R.R. van, Kool, D.R., Witt-Hamer, P.C. de, and Majoie, C.B.
- Abstract
Item does not contain fulltext, Hangman's fractures are a rare finding in childhood. In case of suspected or proven child abuse, differentiation with a congenital defect of the posterior arch of C2 is essential. We present the case of a 5-month-old girl, who had a history of being physically abused by one of her caretakers. On the lateral view of the cervical spine, a defect of the posterior elements of C2 and an anterolisthesis of C2 on C3 was seen. CT scan showed a bilateral defect in the posterior elements of C2. No soft-tissue swelling of hematoma was noted. MRI showed a normal signal intensity of the intervertebral disc C2-C3. No haematoma was noted. Clinical examination revealed a slight head lag and local tenderness; there were no neurological deficits. This case shows that the differentiation between a congenital C2 arch defect and a hangman's fracture is precarious. In this case the findings on MRI and CT scan were interpreted as a congenital posterior arch defect (spondylolysis).
- Published
- 2005
26. External validation of the Canadian CT Head Rule and the New Orleans Criteria for CT scanning in patients with minor head injury.
- Author
-
Smits, M., Dippel, D.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., Hunink, M.G.M., Smits, M., Dippel, D.W., Haan, G.G. de, Dekker, H.M., Vos, P.E., Kool, D.R., Nederkoorn, P.J., Hofman, P.A.M., Twijnstra, A., Tanghe, H.L., and Hunink, M.G.M.
- Abstract
Contains fulltext : 48470.pdf (publisher's version ) (Closed access), CONTEXT: Two decision rules for indications of computed tomography (CT) in patients with minor head injury, the Canadian CT Head Rule (CCHR) and the New Orleans Criteria (NOC), suggest that CT scanning may be restricted to patients with certain risk factors, which would lead to important reductions in the use of CT scans. OBJECTIVE: To validate and compare these 2 published decision rules in Dutch patients with head injuries. DESIGN, SETTING, AND PATIENTS: A prospective multicenter study conducted between February 11, 2002, and August 31, 2004, in 4 university hospitals in the Netherlands of 3181 consecutive adult patients with minor head injury who presented with a Glasgow Coma Scale (GCS) score of 13 to 14 or with a GCS score of 15 and at least 1 risk factor. MAIN OUTCOME MEASURES: Primary outcome was any neurocranial traumatic finding on CT scan. Secondary outcomes were neurosurgical intervention and clinically important CT findings. Sensitivity and specificity were estimated for each outcome for the CCHR and the NOC, using both rules as originally derived and also as adapted to apply to an expanded patient population. RESULTS: Of 3181 patients with a GCS score of 13 to 15, neurosurgical intervention was performed in 17 patients (0.5%); neurocranial traumatic CT findings were present in 312 patients (9.8%). Sensitivity for neurosurgical intervention was 100% for both the CCHR and the NOC. The NOC had a higher sensitivity for neurocranial traumatic findings and for clinically important findings (97.7%-99.4%) than did the CCHR (83.4%-87.2%). Specificities were very low for the NOC (3.0%-5.6%) and higher for the CCHR (37.2%-39.7%). The estimated potential reduction in CT scans for patients with minor head injury would be 3.0% for the adapted NOC and 37.3% for the adapted CCHR. CONCLUSIONS: For patients with minor head injury and a GCS score of 13 to 15, the CCHR has a lower sensitivity than the NOC for neurocranial traumatic or clinically important CT findings, but
- Published
- 2005
27. Emergency department radiology: Reality or luxury? An international comparison
- Author
-
Kool, D.R., primary and Blickman, J.G., additional
- Published
- 2010
- Full Text
- View/download PDF
28. Outcome after Complicated Minor Head Injury
- Author
-
Smits, M., primary, Hunink, M.G.M., additional, van Rijssel, D.A., additional, Dekker, H.M., additional, Vos, P.E., additional, Kool, D.R., additional, Nederkoorn, P.J., additional, Hofman, P.A.M., additional, Twijnstra, A., additional, Tanghe, H.L.J., additional, and Dippel, D.W.J., additional
- Published
- 2007
- Full Text
- View/download PDF
29. An abused five-month-old girl: Hangman’s fracture or congenital arch defect?
- Author
-
van Rijn, R.R., primary, Kool, D.R., additional, de Witt Hamer, P.C., additional, and Majoie, C.B., additional
- Published
- 2005
- Full Text
- View/download PDF
30. Isocaloric feeding and medium chain triglycerides fail to improve liver function tests in a patient with Crohn's disease and a high output stoma
- Author
-
Poldermans, D. and Kool, D.R.
- Published
- 1992
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.