1. Multiagent therapy with pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab ('Pom‐PAD‐Dara') in relapsed/refractory multiple myeloma
- Author
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Zhou, Xiang, Steinhardt, Maximilian J., Grathwohl, Denise, Meckel, Katharina, Nickel, Katharina, Leicht, Hans‐Benno, Krummenast, Franziska, Einsele, Hermann, Rasche, Leo, and Kortüm, Klaus M.
- Subjects
Adult ,Male ,Neutropenia ,lcsh:RC254-282 ,Dexamethasone ,Drug Administration Schedule ,Pom‐PAD‐Dara ,Bortezomib ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,ddc:610 ,Original Research ,Aged ,Retrospective Studies ,Aged, 80 and over ,relapse ,Clinical Cancer Research ,Antibodies, Monoclonal ,Anemia ,Induction Chemotherapy ,Leukopenia ,Pneumonia ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Thrombocytopenia ,Progression-Free Survival ,Thalidomide ,multiple myeloma ,refractory ,Treatment Outcome ,Doxorubicin ,Female ,Neoplasm Recurrence, Local ,Stem Cell Transplantation - Abstract
Background Even in the era of novel immunotherapies for multiple myeloma (MM), treatment of late‐stage relapsed/refractory (RR) patients remains challenging. The aim of our study was to analyze the efficacy and safety of the five‐drug combination pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab (“Pom‐PAD‐Dara”) in RRMM. Methods We retrospectively analyzed data of 56 patients with RRMM who received Pom‐PAD‐Dara between September 2016 and May 2019. Results Patients were heavily pretreated with a median of four prior lines of therapy, including autologous and allogenic stem cell transplant in 50 (89%) and six (11%) patients, respectively. The overall response rate (ORR) was 78% and we observed partial remission, very good partial remission, and complete remission in 27 (48%), 13 (23%) and four (7%) patients, respectively. Median progression‐free survival was 7 months (95% CI, 3.3‐10.7) and the median overall survival was not reached at 24 months. Adverse events grade ≥ 3 were observed 41 (73%) patients and included neutropenia (n = 28, 50%), anemia (n = 22, 39%), thrombocytopenia (n = 21, 38%), and pneumonia (n = 6, 11%). Conclusion Pom‐PAD‐Dara represents a promising multiagent regimen in heavily pretreated RRMM patients with high ORR and an acceptable safety profile., We report on our single‐center experience with a novel five drug combination pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab (“Pom‐PAD‐Dara”). The retrospective analysis of 56 patients showed an impressive overall response rate of 78%, including penta‐refractory patients.
- Published
- 2020