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1. Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Author

Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Gibb, Diana M., Noguera, Antoni, Luisa Navarro, Maria, Tomas Ramos, Jose, Galli, Luisa, Giaquinto, Carlo, Thorne, Claire, Santa Ansone, Marczynska, Magdalena, Okhonskaia, Liubov, de Tejada, Begona Martinez, Jourdain, Gonzague, Decker, Luc, Ene, Luminita, Hainaut, Marc, Van der Kelen, Evelyne, Delforge, Marc, de Martino, Maurizio, Tovo, Pier Angelo, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Lo Vecchio, Andrea, Rampon, Osvalda, Dona, Daniele, Romano, Amelia, Dodi, Icilio, Maccabruni, Anna, Consolini, Rita, Bernardi, Stefania, Kuekou, Hyppolite Tchidjou, Genovese, Orazio, Olmeo, Paolina, Cristiano, Letizia, Mazza, Antonio, Gabiano, Clara, Garazzino, Silvia, Pellegatta, Antonio, Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S., V, van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-de Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, P., Zaheri, S., Bezemer, D. O., van Sighem, A., I, Smit, C., Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, E., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, Jolanta, Pokorska-Spiewak, Maria, Oldakowska, Agnieszka, Zawadka, Konrad, Coupland, Urszula, Doroba, Malgorzata, Voronin, Evgeny, Miloenko, Milana, Labutina, Svetlana, Soler-Palacin, Pere, Antoinette Frick, Maria, Perez-Hoyos, Santiago, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia, Olga, Garcia, Lourdes, Coll, Maite, Pineda, Valenti, Rius, Neus, Rovira, Nuria, Duenas, Joaquin, Gamell, Anna, Fortuny, Claudia, Noguera-Julian, Antoni, Jose Mellado, Maria, Escosa, Luis, Garcia Hortelano, Milagros, Sainz, Talia, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Blazquez, Daniel, Prieto, Luis, Guillen, Sara, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Ruiz, Beatriz, Fernandez Mc Phee, Carolina, Jimenez de Ory, Santiago, Alvarez, Susana, Angel Roa, Miguel, Beceiro, Jose, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Montesdeoca, Abian, Mateo, Mercedes, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Antonio Couceiro, Jose, Perez, Amparo, Isabel Piqueras, Ana, Breton, Rafael, Segarra, Inmaculada, Gavilan, Cesar, Jareno, Enrique, Montesinos, Elena, Dapena, Marta, Alvarez, Cristina, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Isabel Menasalvas, Ana, de Miguel, Elisa, Naver, Lars, Soeria-Atmadja, Sandra, Hagas, Vendela, Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, M., Baumann, M., Bernasconi, E., Boni, J., Braun, D. L., Bucher, H. C., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C. A., Grawe, C., Gunthard, H. F., Haerry, D., Hasse, B., Hirsch, H. H., Hoffmann, M., Hosli, I, Huber, M., Kahlert, C. R., Kaiser, L., Keiser, O., Klimkait, T., Kottanattu, L., Kouyos, R. D., Kovari, H., Ledergerber, B., Martinetti, G., de Tejada, Martinez B., Marzolini, C., Metzner, K. J., Mueller, N., Nicca, D., Paioni, P., Pantaleo, G., Perreau, M., Polli, Ch, Rauch, A., Rudin, C., Scherrer, A. U., Schmid, P., Speck, R., Stockle, M., Tarr, P., Lecompte, Thanh M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C. A., Yerly, S., Wannarit, Pornpun, Techakunakorn, Pornchai, Hansudewechakul, Rawiwan, Wanchaitanawong, Vanichaya, Theansavettrakul, Sookchai, Nanta, Sirisak, Ngampiyaskul, Chaiwat, Phanomcheong, Siriluk, Hongsiriwon, Suchat, Karnchanamayul, Warit, Kwanchaipanich, Ratchanee, Kanjanavanit, Suparat, Kamonpakorn, Nareerat, Nantarukchaikul, Maneeratn, Layangool, Prapaisri, Mekmullica, Jutarat, Lucksanapisitkul, Paiboon, Watanayothin, Sudarat, Lertpienthum, Narong, Warachit, Boonyarat, Hanpinitsak, Sansanee, Potchalongsin, Sathit, Thanasiri, Pimpraphai, Krikajornkitti, Sawitree, Attavinijtrakarn, Pornsawan, Srirojana, Sakulrat, Bunjongpak, Suthunya, Puangsombat, Achara, Na-Rajsima, Sathaporn, Ananpatharachai, Pornchai, Akarathum, Noppadon, Lawtongkum, Weerasak, An, Prapawan Kheunj, Suriyaboon, Thitiporn, Saipanya, Airada, Than-in-at, Kanchana, Jaisieng, Nirattiya, Suaysod, Rapeepan, Chailoet, Sanuphong, Naratee, Naritsara, Kawilapat, Suttipong, Lyall, Hermione, Bamford, Alasdair, Butler, Karim, Doherty, Conor, Foster, Caroline, Francis, Kate, Harrison, Ian, Kenny, Julia, Klein, Nigel, Letting, Gillian, McMaster, Paddy, Murau, Fungai, Nsangi, Edith, Peters, Helen, Prime, Katia, Riordan, Andrew, Shackley, Fiona, Shingadia, Delane, Storey, Sharon, Tudor-Williams, Gareth, Turkova, Anna, Welch, Steve, Collins, Intira Jeannie, Cook, Claire, Dobson, Donna, Fairbrother, Keith, Harper, Lynda, Le Prevost, Marthe, Van Looy, Nadine, Butler, K., Walsh, A., Thrasyvoulou, L., Welch, S., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Sloper, K., Fidler, K., Hague, R., Price, V, Clapson, M., Flynn, J., Abou-Rayyah, A. Cardoso M., Klein, N., Shingadia, D., Gurtin, D., Yeadon, S., Segal, S., Ball, C., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Clough, S., Anguvaa, L., Conway, S., Flood, T., Pickering, A., Murphy, P. McMaster C., Daniels, J., Lees, Y., Thompson, F., Williams, B., Pope, S., Cliffe, L., Smyth, A., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Clarke, D. Rogahn L., Jones, L., Offerman, B., Greenberg, M., Benson, C., Riordan, A., Ibberson, L., Shackley, F., Faust, S. N., Hancock, J., Doerholt, K., Prime, K., Sharland, M., Storey, S., Lyall, H., Monrose, C., Seery, P., Tudor-Williams, G., Menson, E., Callaghan, A., Bridgwood, A., McMaster, P., Evans, J., Blake, E., Yannoulias, A., European Pregnancy Paediat HIV Coh, Microbes in Health and Disease (MHD), Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University [Cambridge]-Chiang Mai University (CMU), Pediatrics, and Virology

Subjects
0301 basic medicine, Male, Pediatrics, puberty, [SDV]Life Sciences [q-bio], humanos, Human immunodeficiency virus (HIV), adolescente, LETTONIE, CHILDREN, HIV Infections, medicine.disease_cause, GRECE, desarrollo del niño, Cohort Studies, 0302 clinical medicine, Child Development, CHILD_DEVELOPMENT, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, ADOLESCENTS, Immunology and Allergy, Pooled data, 030212 general & internal medicine, SUEDE, Child, estudios de cohortes, ESPAGNE, 11 Medical and Health Sciences, Anthropometry, THAILANDE, Europe, growth, height, HIV, perinatal, Thailand, Adolescent, Anti-Retroviral Agents, Child, Preschool, Female, Humans, Infant, Puberty, virus diseases, Growth spurt, PAYS BAS, 3. Good health, 17 Psychology and Cognitive Sciences, AIDS, antirretrovirales, Infectious Diseases, POLOGNE, BELGIQUE, Life Sciences & Biomedicine, medicine.medical_specialty, Pediatric hiv, Epidemiology and Social, ROYAUME UNI, Immunology, MASS, European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, medicine, pubertad, Preschool, lactante, ROUMANIE, Science & Technology, business.industry, 06 Biological Sciences, VELOCITY, SUISSE, Regimen, 030104 developmental biology, VIRAL LOAD, antropometría, infecciones por VIH, BODY_HEIGHT, business, IRLANDE, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group., [Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age., This work has been partially funded by the Fundación para la Investigación y Prevención de SIDA en España (FIPSE) (FIPSE 3608229/09, FIPSE 240800/09, FIPSE 361910/10), Red Temática de Investigación en SIDA (RED RIS) supported by Instituto de Salud Carlos III (ISCIII) (RD12/0017/0035 and RD12/0017/0037), project as part of the Plan R+D+I and cofinanced by ISCIII- Subdirección General de Evaluación and Fondo Europeo de Desarrollo Regional (FEDER),Mutua Madrileña 2012/0077, Gilead Fellowship 2013/0071, FIS PI15/00694,CoRISpe (RED RIS RD06/0006/0035 y RD06/0006/0021).

Published
2019

2. Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand

Author

Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Muñoz, Maria José, Grande, Ana, Romero, Francisco Jose, Wensing, A. M. J., Scholvinck, E. H., Mazza, Antonio, Pérez, Carlos, Jiménez de Ory, Santiago, Henriet, S. S., V, Couceiro, José, Bakker, Y., Zaaijer, H. L., de Tejada, Begona Martinez, Wolfs, T. F. W., Lillo, Miguel, Marczynska, Magdalena, Bezemer, M., Santos, Mar, de Jong, A., Losada, Begoña, Cornelissen, M. T. E., van der Meer, R., Niesters, H. G. M., El Berkaoui, A., Gavilán, César, Gloria Andres, Ana, Rius, Neus, Zaheri, S., Marugan, Victor, Neth, Olaf, Piqueras, Ana I., Ochoa, Carlos, Munjishvili, L., Schnorr, P., Breton, Rafael, Strik-Albers, R., Martínez, Jorge, Grivell, S., Delforge, Marc, Wit, F. W. M. N., Bezemer, D. O., Tuijn, E., de Martino, Maurizio, Paling, E., de Groot-de Jonge, H., Koops, J., Lipreri, Rita, Muñoz-Fernández, María Ángeles, Noguera-Julián, Antoni, Tovo, Pier Angelo, van de Sande, L., Patrizia, Osimani, Saavedra-Lozano, Jesús, Di Biagio, Antonio, Montesinos, Elena, Soler-Palacín, Pere, Berkhout, B., Meijering, R., van der Vliet, S., van Aerde, K., Antoinette Frick, Maria, Salvini, Filippo, Verduyn-Lunel, F., Tagliabue, Claudia, Geerlinks, J., Garrote, Elisa, Rovira, Nuria, Tuk, B., Bergsma, D., Pineda, Valentí, Coupland, Urszula, Tomás Ramos, José, Cellini, Monica, Dueñas, Joaquin, Pellegatta, Antonio, Bustillo Alonso, Matilde, Navarro, Maria Luisa, Pajkrt, D., Badolato, Raffaele, Terol, Pedro, Scherpbier, H. J., Garcia Hortelano, Milagros, Beceiro, Jose, Bernardi, Stefania, Weijsenfeld, A. M., Pocheville, Itziar, López, Núria, Doroba, Malgorzata, Schinkel, C. J., Ruiz, Beatriz, Wolthers, K. C., Fraaij, P. L. A., Fernandez Mc Phee, Carolina, Sainz, Talia, Zawadka, Konrad, van Rossum, A. M. C., Romano, Amelia, Fortuny, Claudia, Peeck, B., Mur, Antonio, Gibb, Diana M., Santa Ansone, Vermont, C. L., Alfayate, Santiago, Apilanez, Miren, Kruijne, E., Okhonskaia, Liubov, van der Knaap, L. C., Méndez, María José, Rojo, Pablo, van Leer-Buter, C. C., Rahamat-Langendoen, J., Angulo, Raquel, Ruggeri, Maurizio, Álvarez, Susana, Knoester, M., Back, N. K. T., Lisi, Catiuscia, Bont, L. J., Guerrero, Carmelo, Larovere, Domenico, Mellado, Maria Jose, Herranz, Mercedes, Colino, Elena, Raethke, M., Badillo, Katie, Roa, Miguel Angel, Collado, Pilar, Rutkens, T., Gonzalez-Tome, Maria I., Lo Vecchio, Andrea, Pas, S. D., Falcón Neyra, Lola, Venturini, Elisabetta, de Groot, L., Jareno, Enrique, van den Akker, M., Olmeo, Paolina, Lucas, E., Decker, Luc, Segarra, Inmaculada, Gomez Sirvent, Jorge, Perez, Amparo, Thorne, Claire, Menasalvas, Ana Isabel, Ree, C., Hillebregt, M., Regtop, R., Nauta, N., Faldella, Giacomo, Jourdain, Gonzague, Moreno-Pérez, David, Taramasso, Lucia, Álvarez, Cristina, Reiss, Peter, Ruijs, Y., Baldi, Francesco, Voronin, Evgeny, Boucher, C. A. B., Galli, Luisa, Miguel, E. de, Wisse, A., Miloenko, Milana, Giacomet, Vania, Labutina, Svetlana, Witte, E. C., Consolini, Rita, Smit, C., Hainaut, Marc, Mayol, Lluis, Rampon, Osvalda, Vallmanya, Teresa, Giaquinto, Carlo, Dona, Daniele, Erba, Paola, Dapena, Marta, Calavia, Olga, Veenenberg, L., Montagnani, Carlotta, van de Flier, M., Schuurman, R., Bruzzese, Eugenia, García, Lourdes, Geelen, S. P. M., Coll, María T., Oldakowska, Agnieszka, de Boer, C. G., Genovese, Orazio, Van der Kelen, Evelyne, Blázquez-Gamero, Daniel, Escosa-García, Luis, Jurriaans, S., Dodi, Icilio, Santos, Juan Luis, Prieto, Luís, Perez-Hoyos, Santiago, Lodewijk, C., Guillén, Sara, Koopmans, M. P. G., Ene, Luminita, Visser, E. G., Gabiano, Clara, Garzon, Monica, Kuekou, Hyppolite Tchidjou, Maccabruni, Anna, van Kampen, J. J. A., Roman, Vicente, Esposito, Susanna, Schoorl, M., Gamell, Anna, Cristiano, Letizia, Montesdeoca, Abián, Stelma, F. F., Mateo, Mercedes, Pokorska-Spiewak, Maria, van Sighem, A., I, Woudstra, T., Popielska, Jolanta, Garazzino, Silvia, Lendinez, Francisco, Fundación Investigación y Educación en Sida, Instituto de Salud Carlos III, European Commission, Fundación Mutua Madrileña, Crichton, Siobhan, Belfrage, Eric, Collins, Intira Jeanne, Doerholt, Katja, Judd, Ali, Le Coeur, Sophie, Spoulou, Vana, Goodall, Ruth, Scherpbier, Henriette, Smit, Colette, Goetghebuer, Tessa, Muñoz, Maria José, Grande, Ana, Romero, Francisco Jose, Wensing, A. M. J., Scholvinck, E. H., Mazza, Antonio, Pérez, Carlos, Jiménez de Ory, Santiago, Henriet, S. S., V, Couceiro, José, Bakker, Y., Zaaijer, H. L., de Tejada, Begona Martinez, Wolfs, T. F. W., Lillo, Miguel, Marczynska, Magdalena, Bezemer, M., Santos, Mar, de Jong, A., Losada, Begoña, Cornelissen, M. T. E., van der Meer, R., Niesters, H. G. M., El Berkaoui, A., Gavilán, César, Gloria Andres, Ana, Rius, Neus, Zaheri, S., Marugan, Victor, Neth, Olaf, Piqueras, Ana I., Ochoa, Carlos, Munjishvili, L., Schnorr, P., Breton, Rafael, Strik-Albers, R., Martínez, Jorge, Grivell, S., Delforge, Marc, Wit, F. W. M. N., Bezemer, D. O., Tuijn, E., de Martino, Maurizio, Paling, E., de Groot-de Jonge, H., Koops, J., Lipreri, Rita, Muñoz-Fernández, María Ángeles, Noguera-Julián, Antoni, Tovo, Pier Angelo, van de Sande, L., Patrizia, Osimani, Saavedra-Lozano, Jesús, Di Biagio, Antonio, Montesinos, Elena, Soler-Palacín, Pere, Berkhout, B., Meijering, R., van der Vliet, S., van Aerde, K., Antoinette Frick, Maria, Salvini, Filippo, Verduyn-Lunel, F., Tagliabue, Claudia, Geerlinks, J., Garrote, Elisa, Rovira, Nuria, Tuk, B., Bergsma, D., Pineda, Valentí, Coupland, Urszula, Tomás Ramos, José, Cellini, Monica, Dueñas, Joaquin, Pellegatta, Antonio, Bustillo Alonso, Matilde, Navarro, Maria Luisa, Pajkrt, D., Badolato, Raffaele, Terol, Pedro, Scherpbier, H. J., Garcia Hortelano, Milagros, Beceiro, Jose, Bernardi, Stefania, Weijsenfeld, A. M., Pocheville, Itziar, López, Núria, Doroba, Malgorzata, Schinkel, C. J., Ruiz, Beatriz, Wolthers, K. C., Fraaij, P. L. A., Fernandez Mc Phee, Carolina, Sainz, Talia, Zawadka, Konrad, van Rossum, A. M. C., Romano, Amelia, Fortuny, Claudia, Peeck, B., Mur, Antonio, Gibb, Diana M., Santa Ansone, Vermont, C. L., Alfayate, Santiago, Apilanez, Miren, Kruijne, E., Okhonskaia, Liubov, van der Knaap, L. C., Méndez, María José, Rojo, Pablo, van Leer-Buter, C. C., Rahamat-Langendoen, J., Angulo, Raquel, Ruggeri, Maurizio, Álvarez, Susana, Knoester, M., Back, N. K. T., Lisi, Catiuscia, Bont, L. J., Guerrero, Carmelo, Larovere, Domenico, Mellado, Maria Jose, Herranz, Mercedes, Colino, Elena, Raethke, M., Badillo, Katie, Roa, Miguel Angel, Collado, Pilar, Rutkens, T., Gonzalez-Tome, Maria I., Lo Vecchio, Andrea, Pas, S. D., Falcón Neyra, Lola, Venturini, Elisabetta, de Groot, L., Jareno, Enrique, van den Akker, M., Olmeo, Paolina, Lucas, E., Decker, Luc, Segarra, Inmaculada, Gomez Sirvent, Jorge, Perez, Amparo, Thorne, Claire, Menasalvas, Ana Isabel, Ree, C., Hillebregt, M., Regtop, R., Nauta, N., Faldella, Giacomo, Jourdain, Gonzague, Moreno-Pérez, David, Taramasso, Lucia, Álvarez, Cristina, Reiss, Peter, Ruijs, Y., Baldi, Francesco, Voronin, Evgeny, Boucher, C. A. B., Galli, Luisa, Miguel, E. de, Wisse, A., Miloenko, Milana, Giacomet, Vania, Labutina, Svetlana, Witte, E. C., Consolini, Rita, Smit, C., Hainaut, Marc, Mayol, Lluis, Rampon, Osvalda, Vallmanya, Teresa, Giaquinto, Carlo, Dona, Daniele, Erba, Paola, Dapena, Marta, Calavia, Olga, Veenenberg, L., Montagnani, Carlotta, van de Flier, M., Schuurman, R., Bruzzese, Eugenia, García, Lourdes, Geelen, S. P. M., Coll, María T., Oldakowska, Agnieszka, de Boer, C. G., Genovese, Orazio, Van der Kelen, Evelyne, Blázquez-Gamero, Daniel, Escosa-García, Luis, Jurriaans, S., Dodi, Icilio, Santos, Juan Luis, Prieto, Luís, Perez-Hoyos, Santiago, Lodewijk, C., Guillén, Sara, Koopmans, M. P. G., Ene, Luminita, Visser, E. G., Gabiano, Clara, Garzon, Monica, Kuekou, Hyppolite Tchidjou, Maccabruni, Anna, van Kampen, J. J. A., Roman, Vicente, Esposito, Susanna, Schoorl, M., Gamell, Anna, Cristiano, Letizia, Montesdeoca, Abián, Stelma, F. F., Mateo, Mercedes, Pokorska-Spiewak, Maria, van Sighem, A., I, Woudstra, T., Popielska, Jolanta, Garazzino, Silvia, and Lendinez, Francisco

Abstract

[Objective]: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. [Design]: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. [Methods]: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1–10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. [Results]: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and −1.2 (IQR: −2.3 to −0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20–0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21–1.78) years later in those starting with HAZ less than −3 compared with HAZ at least −1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than −1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least −1, there was no association with age. Girls and boys who initiated ART with HAZ at least −1 maintained a similar height to the WHO reference mean. [Conclusion]: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least −1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age.

Published
2019

5. Early highly active antiretroviral therapy enhances B-cell longevity: a 5 year follow up

Author

Paolo Palma, Emma Concetta Manno, Stefania Bernardi, Angela Aquilani, Carlo Giaquinto, Paola Zangari, Nicola Cotugno, Nadia Mora, Kuekou Hyppolite Tchidjou, Veronica Santilli, Stefano Rinaldi, Alberto Cagigi, and Paolo Giorgi Rossi

Subjects
Microbiology (medical), Male, Pediatrics, medicine.medical_specialty, Enzyme-Linked Immunospot Assay, 5 year follow up, Time Factors, Adolescent, Cell Survival, media_common.quotation_subject, Enzyme-Linked Immunosorbent Assay, HIV Infections, Early initiation, Antibodies, Young Adult, Immunity, Antiretroviral Therapy, Highly Active, medicine, Humans, Young adult, Child, B cell, media_common, B-Lymphocytes, Vaccines, business.industry, Longevity, Flow Cytometry, Antiretroviral therapy, Vaccination, Infectious Diseases, medicine.anatomical_structure, Anti-Retroviral Agents, Pediatrics, Perinatology and Child Health, Immunology, Female, business, Follow-Up Studies
Abstract

We have previously reported that an early initiation of highly active antiretroviral therapy (HAART) in HIV-1 vertically infected children enhanced the function of memory B-cells gained during childhood routine vaccinations. On the other hand, a significant waning of immunity was observed for patients with a late treatment. In this follow-up study, we report data from a sample of patients in our cohort including late-treated patients being revaccinated with routine childhood vaccines.The levels of serum antibodies and cellular immunity were measured by antigen-specific enzyme-linked immunosorbent assay and B-cell ELISpot. Moreover, flow cytometry on the frequencies of mature-activated (CD10-CD21-) and double-negative (CD27-IgD-) B-cells as hallmarks of immune activation and immune senescence, respectively, was performed for all patients.Reduced protective humoral immunity and cellular immunity to routine childhood vaccines was observed in late-treated patients. Moreover, we found that timing of HAART related with the frequencies of mature activated and double negative.Altogether the data presented in this follow-up study reenforce the importance for an early start of HAART in HIV-1 vertically infected individuals and suggest that timing of HAART is a fundamental factor to take into account for vaccination design in this population.

Published
2014

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