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1. Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study.

Author

Auvinen, A, Cardis, E, Blettner, M, Moissonnier, M, Sadetzki, S, Giles, G, Johansen, C, Swerdlow, A, Cook, A, Fleming, S, Berg-Beckhoff, G, Iavarone, I, Parent, M-E, Woodward, A, Tynes, T, McBride, M, Krewski, D, Feychting, M, Takebayashi, T, Armstrong, B, Hours, M, Siemiatycki, J, Lagorio, S, Larsen, SB, Schoemaker, M, Klaeboe, L, Lönn, S, Schüz, J, INTERPHONE study group, Auvinen, A, Cardis, E, Blettner, M, Moissonnier, M, Sadetzki, S, Giles, G, Johansen, C, Swerdlow, A, Cook, A, Fleming, S, Berg-Beckhoff, G, Iavarone, I, Parent, M-E, Woodward, A, Tynes, T, McBride, M, Krewski, D, Feychting, M, Takebayashi, T, Armstrong, B, Hours, M, Siemiatycki, J, Lagorio, S, Larsen, SB, Schoemaker, M, Klaeboe, L, Lönn, S, Schüz, J, and INTERPHONE study group

Abstract

BACKGROUND: Exposure to high doses of ionizing radiation is among the few well-established brain tumour risk factors. We used data from the Interphone study to evaluate the effects of exposure to low-dose radiation from diagnostic radiological examinations on glioma, meningioma and acoustic neuroma risk. METHODS: Brain tumour cases (2644 gliomas, 2236 meningiomas, 1083 neuromas) diagnosed in 2000-02 were identified through hospitals in 13 countries, and 6068 controls (population-based controls in most centres) were included in the analysis. Participation across all centres was 64% for glioma cases, 78% for meningioma cases, 82% for acoustic neuroma cases and 53% for controls. Information on previous diagnostic radiological examinations was obtained by interviews, including the frequency, timing and indication for the examinations. Typical brain doses per type of examination were estimated based on the literature. Examinations within the 5 years before the index date were excluded from the dose estimation. Adjusted odds ratios were estimated using conditional logistic regression. RESULTS: No materially or consistently increased odds ratios for glioma, meningioma or acoustic neuroma were found for any specific type of examination, including computed tomography of the head and cerebral angiography. The only indication of an elevated risk was an increasing trend in risk of meningioma with the number of isotope scans, but no such trends for other examinations were observed. No gradient was found in risk with estimated brain dose. Age at exposure did not substantially modify the findings. Sensitivity analyses gave results consistent with the main analysis. CONCLUSIONS: There was no consistent evidence for increased risks of brain tumours with X-ray examinations, although error from selection and recall bias cannot be completely excluded. A cautious interpretation is warranted for the observed association between isotope scans and meningioma.

Published
2022

2. Determinants of mobile phone output power in a multinational study: implications for exposure assessment

Author

Vrijheid, M, Mann, S, Vecchia, P, Wiart, J, Taki, M, Ardoino, L, Armstrong, B K, Auvinen, A, Bédard, D, Berg-Beckhoff, G, Brown, J, Chetrit, A, Collatz-Christensen, H, Combalot, E, Cook, A, Deltour, I, Feychting, M, Giles, G G, Hepworth, S J, Hours, M, Iavarone, I, Johansen, C, Krewski, D, Kurttio, P, Lagorio, S, Lönn, S, McBride, M, Montestrucq, L, Parslow, R C, Sadetzki, S, Schüz, J, Tynes, T, Woodward, A, and Cardis, E

Published
2009

3. Validation of Short Term Recall of Mobile Phone Use for the Interphone Study

Author

Interphone Study Group, Vrijheid, M., Cardis, E., Armstrong, B. K., Auvinen, A., Berg, G., Blaasaas, K. G., Brown, J., Carroll, M., Chetrit, A., Christensen, H. C., Deltour, I., Feychting, M., Giles, G. G., Hepworth, S. J., Hours, M., Iavarone, I., Johansen, C., Klæboe, L., Kurttio, P., Lagorio, S., Lönn, S., McKinney, P. A., Montestrucq, L., Parslow, R. C., Richardson, L., Sadetzki, S., Salminen, T., Schüz, J., Tynes, T., and Woodward, A.

Published
2006
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4. Radiazioni a radiofrequenze e tumori: sintesi delle evidenze scientifiche

Author

Lagorio S., Anglesio L., D'Amore G, Marino C, and Scarfì MR.

Subjects
Radiofrequenze, Tumori dell'ipofisi, Tumori delle ghiandole salivari, Onde radio, Campi elettromagnetici, Leucemia, Epidemiologia, Modelli animal, Telefono cellulare, Test di cancerogenicità, Valutazione del rischio, Radiazioni non-ionizzanti, Glioma, Meningioma, Neuroma acustico
Abstract

Le radiazioni a radiofrequenze (100 kHz-300 GHz) sono utilizzate nelle telecomunicazioni e in molte altre applicazioni biomediche e industriali, con esposizioni ubiquitarie negli ambienti di vita e di lavoro. Gli eventuali effetti nocivi di queste esposizioni, oggetto di un'intensa attività di ricerca, sono anche caratterizzati da una elevata percezione dei rischi da parte della popolazione, con conseguente richiesta di un'esauriente informazione. Questo rapporto, indirizzato agli operatori del Servizio Sanitario Nazionale e del Sistema Nazionale delle Agenzie di Protezione Ambientale, vuole fornire una descrizione delle caratteristiche dell'esposizione a campi elettromagnetici a radiofrequenze e una presentazione delle evidenze epidemiologiche e sperimentali sui rischi per la salute derivanti da queste esposizioni. Il rapporto è focalizzato in particolare sulla relazione tra le sorgenti che destano maggiore preoccupazione (telefoni cellulari, antenne radio-televisive, stazioni radio base e impianti WLAN/WiFi) e sugli effetti a lungo termine più rilevanti per la salute dell'uomo, i tumori.

Published
2019

5. Validation of short term recall of mobile phone use for the Interphone study

Author

Vrijheid, M, Cardis, E, Armstrong, B K, Auvinen, A, Berg, G, Blaasaas, K G, Brown, J, Carroll, M, Chetrit, A, Christensen, H C, Deltour, I, Feychting, M, Giles, G G, Hepworth, S J, Hours, M, Iavarone, I, Johansen, C, Klæboe, L, Kurttio, P, Lagorio, S, Lönn, S, McKinney, P A, Montestrucq, L, Parslow, R C, Richardson, L, Sadetzki, S, Salminen, T, Schüz, J, Tynes, T, and Woodward, A

Published
2006

6. Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study

Author

Miligi L, Benvenuti A, Salvan A, Tozzi GA, Ranucci A, Legittimo P, Bisanti L, Zambon P, Cannizzaro S, Kirchmayer U, Cocco P, Celentano E, Assennato G, Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa V, Lagorio S, Haupt R, Risica S, Polichetti A, SETIL Working Group, Magnani C., MATTIOLI, STEFANO, RONDELLI, ROBERTO, Miligi L, Benvenuti A, Mattioli S, Salvan A, Tozzi GA, Ranucci A, Legittimo P, Rondelli R, Bisanti L, Zambon P, Cannizzaro S, Kirchmayer U, Cocco P, Celentano E, Assennato G, Merlo DF, Mosciatti P, Minelli L, Cuttini M, Torregrossa V, Lagorio S, Haupt R, Risica S, Polichetti A, SETIL Working Group, Magnani C., Miligi, L., Benvenuti, A., Mattioli, S., Salvan, A., Tozzi, G., Ranucci, A., Legittimo, P., Rondelli, R., Bisanti, L., Zambon, P., Cannizzaro, S., Kirchmayer, U., Cocco, P., Celentano, E., Assennato, G., Merlo, D., Mosciatti, P., Minelli, L., Cuttini, M., Torregrossa, V., Lagorio, S., Haupt, R., Risica, S., Polichetti, A., and Magnani, C.

Subjects
Male, Toxicology, Economica, Pregnancy, hemic and lymphatic diseases, Epidemiology, Child, Multivariate Analysi, parental exposure, Incidence, Lymphoma, Non-Hodgkin, Incidence (epidemiology), Precursor Cell Lymphoblastic Leukemia-Lymphoma, Occupational exposure, Epidemiologic Studie, Italy, Maternal Exposure, Chemical Industry, Child, Preschool, Prenatal Exposure Delayed Effects, Solvent, Paternal Exposure, Female, Survival Analysi, HYDROCARBONS, Case-Control Studie, Risk assessment, Human, medicine.medical_specialty, Logistic Model, Adolescent, Socio-culturale, Context (language use), Risk Assessment, Prenatal Exposure Delayed Effect, Hazardous Substances, Age Distribution, Environmental health, medicine, Humans, Sex Distribution, Survival analysis, ACUTE LYMPHOBLASTIC-LEUKEMIA, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Ambientale, medicine.disease, Survival Analysis, Non-Hodgkin's lymphoma, Epidemiologic Studies, Logistic Models, solvents, Hazardous Substance, Case-Control Studies, Multivariate Analysis, business
Abstract

AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. RESULTS: 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.7) and mineral oils (OR 1.4)[corrected]. Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). CONCLUSIONS: We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.

Published
2013

7. Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy

Author

Magnani, C, Ranucci, A, Badaloni, C, Cesaroni, G, Ferrante, D, Miligi, L, Mattioli, S, Rondelli, R, Bisanti, L, Zambon, P, Cannizzaro, S, Michelozzi, P, Cocco, P, Celentano, E, Assennato, G, Merlo, D, Mosciatti, P, Minelli, L, Cuttini, M, Torregrossa, M, Lagorio, S, Haupt, R, Forastiere, F, Farioli, A, Salvan, A, Masera, G, Rizzari, C, Greco Veneto, A, Gafa, L, Luzzatto, L, Benvenuti, A, Kirchmayer, U, Galassi, C, Guarino, E, de Nichilo, G, Bocchini, V, Chiavarini, M, Casotto, V, Valenti, R, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Arico, M, Desalvo, G, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Pannelli, F, Sampietro, G, Schiliro, G, Pulsoni, A, Parodi, S, Magnani C., Ranucci A., Badaloni C., Cesaroni G., Ferrante D., Miligi L., Mattioli S., Rondelli R., Bisanti L., Zambon P., Cannizzaro S., Michelozzi P., Cocco P., Celentano E., Assennato G., Merlo D. F., Mosciatti P., Minelli L., Cuttini M., Torregrossa M. V., Lagorio S., Haupt R., Forastiere F., Farioli A., Salvan A., Masera G., Rizzari C., Greco Veneto A., Gafa L., Luzzatto L. L., Benvenuti A., Kirchmayer U., Galassi C., Guarino E., de Nichilo G., Bocchini V., Chiavarini M., Casotto V., Valenti R. M., Risica S., Polichetti A., Bochicchio F., Nuccetelli C., Biddau P., Arico M., DeSalvo G. L., Locatelli F., Pession A., Varotto S., Poggi V., Massaglia P., Monetti D., Targhetta R., Bernini G., Pannelli F., Sampietro G., Schiliro G., Pulsoni A., Parodi S., Magnani, C, Ranucci, A, Badaloni, C, Cesaroni, G, Ferrante, D, Miligi, L, Mattioli, S, Rondelli, R, Bisanti, L, Zambon, P, Cannizzaro, S, Michelozzi, P, Cocco, P, Celentano, E, Assennato, G, Merlo, D, Mosciatti, P, Minelli, L, Cuttini, M, Torregrossa, M, Lagorio, S, Haupt, R, Forastiere, F, Farioli, A, Salvan, A, Masera, G, Rizzari, C, Greco Veneto, A, Gafa, L, Luzzatto, L, Benvenuti, A, Kirchmayer, U, Galassi, C, Guarino, E, de Nichilo, G, Bocchini, V, Chiavarini, M, Casotto, V, Valenti, R, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Arico, M, Desalvo, G, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Pannelli, F, Sampietro, G, Schiliro, G, Pulsoni, A, Parodi, S, Magnani C., Ranucci A., Badaloni C., Cesaroni G., Ferrante D., Miligi L., Mattioli S., Rondelli R., Bisanti L., Zambon P., Cannizzaro S., Michelozzi P., Cocco P., Celentano E., Assennato G., Merlo D. F., Mosciatti P., Minelli L., Cuttini M., Torregrossa M. V., Lagorio S., Haupt R., Forastiere F., Farioli A., Salvan A., Masera G., Rizzari C., Greco Veneto A., Gafa L., Luzzatto L. L., Benvenuti A., Kirchmayer U., Galassi C., Guarino E., de Nichilo G., Bocchini V., Chiavarini M., Casotto V., Valenti R. M., Risica S., Polichetti A., Bochicchio F., Nuccetelli C., Biddau P., Arico M., DeSalvo G. L., Locatelli F., Pession A., Varotto S., Poggi V., Massaglia P., Monetti D., Targhetta R., Bernini G., Pannelli F., Sampietro G., Schiliro G., Pulsoni A., and Parodi S.

Abstract

Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. Aim of the study We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic. Methods We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic–ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls. Information on traffic exposure was collected from questionnaire interviews and from the geocoding of house addresses, for all periods of life of the children. Results We observed an increase in risk for AnLL, and at a lower extent for ALL, with indicators of exposure to traffic pollutants. In particular, the risk was associated to the report of closeness of the house to traffic lights and to the passage of trucks (OR: 1.76; 95% CI 1.03–3.01 for ALL and 6.35; 95% CI 2.59–15.6 for AnLL). The association was shown also in the analyses limited to AML and in the stratified analyses and in respect to the house in different period of life. Conclusions Results from the SETIL study provide some support to the association of traffic related exposure and risk for AnLL, but at a lesser extent for ALL. Our conclusion highlights the need for leukemia type specific analyses in future studies. Results support the need of controlling exposure from traffic pollution, even if knowledge is not complete.

Published
2016

8. Adapted Physical Activity for the Promotion of Health and the Prevention of Multifactorial Chronic Diseases: the Erice Charter

Author

Spica V. R., Macini P., Galeone D., Liguori G., Signorelli C., Marensi L., Vagali P., Guberti E., Goletti M., Mammina C., Tabacchi G., Izzotti A., Cinquetti S., Pellizzari B., Beltrami P., Alonzo E., Gradilone A., Leoni E., Buono P., Brandi G., Di Rosa E., Parisi A., Capolongo S., Fantuzzi G., Aggazzotti G., Grillo C., Borella P., Manzoli L., Fabiani L., Faggiano F., Mete R., Privitera G., Coniglio M. A., Frangella C., Rossi D., Lagorio S., Pasquarella M. L., Isabella A., Tripi F., Franceschetti R., Commare A. L., Galle F., Brandimarte M. A., Savino G., Di Onofrio V., Tortorella F., Gabriele M., Monreale V., Abrignani M., Ferreri G., Cacciapuoti A., Valeriani F., Raffo M., Matarese M., Ripani M., Altana V., Antonioni S., Anzalone C., Astorino G., Azzollini A., Belfiore P., Valentini F. B., Bragazzi N. L., Calaciura A., Casano D., Ciulla A., Cono O. E., Contrisciani R., Cosenza B., D'Aloisio F., Antonino D. F., Marchis A. D., Francesco D. N., Fabri S., Famiglietti E., Gandolfi A., Genovese C., Genovesi A., Gianfredi V., Gigante S., Gigliotti A., Iacona C., Innocenzi L., Laurita V., Maratea F., Meletti L., Memmini S., Messana M. A., Morelli C., Nappi M. R., Nucci D., Orlandi P., Palamara M. A. R., Patti A., Persi Y., Polisano B., Roccaro D., Ricchiuti R., Sanclemente L., Scanavini S., Sirtori M. D., Soncini F., Stelitano G. I., Valenzano A. A., Veicsteinas A., Fara G. M., Giammanco G., Romano-Spica V., Spica V.R., Macini P., Galeone D., Liguori G., Signorelli C., Marensi L., Vagali P., Guberti E., Goletti M., Mammina C., Tabacchi G., Izzotti A., Cinquetti S., Pellizzari B., Beltrami P., Alonzo E., Gradilone A., Leoni E., Buono P., Brandi G., Di Rosa E., Parisi A., Capolongo S., Fantuzzi G., Aggazzotti G., Grillo C., Borella P., Manzoli L., Fabiani L., Faggiano F., Mete R., Privitera G., Coniglio M.A., Frangella C., Rossi D., Lagorio S., Pasquarella M.L., Isabella A., Tripi F., Franceschetti R., Commare A.L., Galle F., Brandimarte M.A., Savino G., Di Onofrio V., Tortorella F., Gabriele M., Monreale V., Abrignani M., Ferreri G., Cacciapuoti A., Valeriani F., Raffo M., Matarese M., Ripani M., Altana V., Antonioni S., Anzalone C., Astorino G., Azzollini A., Belfiore P., Valentini F.B., Bragazzi N.L., Calaciura A., Casano D., Ciulla A., Cono O.E., Contrisciani R., Cosenza B., D'Aloisio F., Antonino D.F., Marchis A.D., Francesco D.N., Fabri S., Famiglietti E., Gandolfi A., Genovese C., Genovesi A., Gianfredi V., Gigante S., Gigliotti A., Iacona C., Innocenzi L., Laurita V., Maratea F., Meletti L., Memmini S., Messana M.A., Morelli C., Nappi M.R., Nucci D., Orlandi P., Palamara M.A.R., Patti A., Persi Y., Polisano B., Roccaro D., Ricchiuti R., Sanclemente L., Scanavini S., Sirtori M.D., Soncini F., Stelitano G.I., Valenzano A.A., Veicsteinas A., Fara G.M., Giammanco G., and Romano-Spica V.

Subjects
Biomedical Research, Prevention parole chiave, Adapted physical activity, Health Promotion, Motor Activity, Health promotion, Prevention, Primary Prevention, Attività fisica adattata, Prevenzione, Italy, Physician, Promozione della salute, Chronic Disease, Public Health, Human, Specialization
Abstract

The Erice Charter was unanimously approved at the conclusion of the 47th Residential Course "Adapted Physical Activity in Sport, Wellness and Fitness: New Challenges for Prevention and Health Promotion", held on 20-24 April 2015 in Erice, Italy, at the "Ettore Majorana" Foundation and Centre for Scientific Culture, and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group on Movement Sciences for Health of the Italian Society of Hygiene, Preventive Medicine and Public Health. After an intense discussion the participants identified the main points associated with the relevance of physical activity for Public Health, claiming the pivotal role of the Department of Prevention in coordinating and managing preventive actions. The participants underlined the importance of the physicians specialized in Hygiene, Preventive Medicine and Public Health. The contribution of other operators such as physicians specialized in Sport Medicine was stressed. Further, the holders of the new degree in Human Movement and Sport Sciences were considered fundamental contributors for the performance of physical activity and their presence was seen as a promising opportunity for the Departments of Prevention. Primary prevention based on recreational physical activities should become easily accessible for the population, avoiding obstacles such as certification steps or complex bureaucracy. The Sport Doctor is recognized as the principal referent for preliminary physical evaluation and clinical monitoring in secondary and tertiary prevention actions based on adapted physical activities. Developing research in the field is essential as well as implementing higher education on physical activity management in Schools of Public Health.

Published
2015

10. Air pollution and childhood leukaemia: a nationwide case-control study in Italy

Author

Badaloni, C., Ranucci, A., Cesaroni, G., Zanini, G., Vienneau, D., Al Aidrous, F., De Hoogh, K., Magnani, C., Forastiere, F., Mattioli, Stefano, Miligi, L., Rondelli, R., Salvan, A., Masera, G., Rizzari, C., Bisanti, L., Zambon, P., Greco, A., Cannizzaro, S., Gafa, L., Luzzatto, L. L., Benvenuti, A., Michelozzi, P., Kirchmayer, U., Cocco, P., Galassi, C., Celentano, E., Guarino, E., Assennato, G., de Nichilo, G., Merlo, D. F., Bocchini, V., Mosciatti, P., Minelli, L., Chiavarini, M., Cuttini, M., Casotto, V., Torregrossa, M. V., Valenti, R. M., Haupt, R., Lagorio, S., Risica, S., Polichetti, A., Bochicchio, F., Nuccetelli, C., Biddau, P., Arico, M., De Salvo, G. L., Locatelli, F., Pession, Andrea, Varotto, S., Poggi, V., Massaglia, P., Monetti, D., Targhetta, R., Bernini, G., Pannelli, F., Sampietro, G., Schiliro, G., Pulsoni, A., Badaloni, C., Ranucci, A., Cesaroni, G., Zanini, G., Vienneau, D., Al-Aidrous, F., De Hoogh, K., Magnani, C., Forastiere, F., C. Badaloni, A. Ranucci, G. Cesaroni, G. Zanini, D. Vienneau, F. Al-Aidrou, K. De Hoogh, C. Magnani, F. Forastiere, S. Mattioli, L. Miligi, R. Rondelli, A. Salvan, G. Masera, C. Rizzari, L. Bisanti, P. Zambon, A. Greco, S. Cannizzaro, L. Gafa, L. L. Luzzatto, A. Benvenuti, P. Michelozzi, U. Kirchmayer, P. Cocco, C. Galassi, E. Celentano, E. Guarino, G. Assennato, G. de Nichilo, D. F. Merlo, V. Bocchini, P. Mosciatti, L. Minelli, M. Chiavarini, M. Cuttini, V. Casotto, M. V. Torregrossa, R. M. Valenti, R. Haupt, S. Lagorio, S. Risica, A. Polichetti, F. Bochicchio, C. Nuccetelli, P. Biddau, M. Arico, G. L. De Salvo, F. Locatelli, A. Pession, S. Varotto, V. Poggi, P. Massaglia, D. Monetti, R. Targhetta, G. Bernini, F. Pannelli, G. Sampietro, G. Schiliro, and A. Pulsoni

Subjects
Male, Pediatrics, Air pollution, NO2, Land use Regression Model, Logistic regression, medicine.disease_cause, Economica, Residence Characteristics, USE REGRESSION-MODELS, Medicine, Child, Children, Vehicle Emissions, General Environmental Science, USE REGRESSION-MODELS, RESIDENTIAL TRAFFIC DENSITY, MAGNETIC-FIELDS, POOLED ANALYSIS, RISK-FACTOR, CANCER, EXPOSURE, CHILDREN, NO2, ASSOCIATION, Leukemia, Incidence, Incidence (epidemiology), ASSOCIATION, CANCER, Childhood leukaemia, Italy, Child, Preschool, Female, Case-Control Studie, Human, medicine.medical_specialty, Socio-culturale, MAGNETIC-FIELDS, POOLED ANALYSIS, RISK-FACTOR, Air Pollution, Occupational Exposure, Environmental health, Traffic Indicator, Humans, EXPOSURE, RESIDENTIAL TRAFFIC DENSITY, Exposure assessment, Vehicle Emission, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Ambientale, Infant, Carcinogens, Environmental, Automobile, Case-Control Studies, Residence Characteristic, Dispersion Model, Etiology, General Earth and Planetary Sciences, Particulate Matter, Residence, business, Automobiles
Abstract

Objectives Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leukaemia because of chronic exposure to several potential carcinogens. Methods The Italian SETIL study (Study on the aetiology of lymphohematopoietic malignancies in children) was conducted in 14 Italian regions. All incident cases of leukaemia in children aged ≤10 years from these regions (period 1998–2001) were eligible for enrolment. Two controls per case, matched on birth date, gender and region of residence were randomly selected from the local population registries. Exposure assessment at birth residence included traffic indicators (distance to main roads and length of main roads within 100 m) and estimates of pollutants concentrations (particulate matter -PM 2.5 and PM 10 - and gases -NO 2 and O 3 -) from national dispersion model and land use regression models. The association between the exposure variables and leukaemia was assessed by logistic regression analyses. Results Participation rates were 91.4% among cases and 69.2% in controls; 620 cases (544 acute lymphocytic and 76 acute non-lymphocytic leukaemia) and 957 controls were included. Overall, when considering the residence at birth, 35.6% of cases and 42.4% of controls lived along busy roads, and the mean annual PM 10 levels were 33.3 (SD=6.3) and 33.4 µg/m 3 (SD=6.5), respectively. No association was found, and all ORs, independent of the method of assessment and the exposure windows, were close to the null value. Conclusions Using various exposure assessment strategies, air pollution appears not to affect the incidence of childhood leukaemia.

Published
2013

12. Italian multicentricepidemiological case control strudy on risk factors for childhood leukemia,non hodgkin limphoma and neuroblastoma:study population and prevalence of risk factors in Italy

Author

Magnani, C, Mattioli, S, Miligi, L, Ranucci, A, Rondelli, R, Salvan, A, Bisanti, L, Masera, G, Rizzari, C, Zambon, P, Cannizzaro, S, Gafà, L, Luzzatto, LL, Benvenuti, A, Michelozzi, P, Kirchmayer, U, Cocco, P, Biddau, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, Nichilo, GD, Merlo, DF, Bocchini, V, Pannelli, F, Mosciatti, P, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Forastiere, F, Haupt, R, Lagorio, S, Risica, S, Polichetti, A., TORREGROSSA, Maria Valeria, VALENTI, Rosalia Maria, Magnani, C, Mattioli, S, Miligi, L, Ranucci, A, Rondelli, R, Salvan, A, Bisanti, L, Masera, G, Rizzari, C, Zambon, P, Cannizzaro, S, Gafà, L, Luzzatto, LL, Benvenuti, A, Michelozzi, P, Kirchmayer, U, Cocco, P, Biddau, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, Nichilo, GD, Merlo, DF, Bocchini, V, Pannelli, F, Mosciatti, P, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Torregrossa, MV, Valenti, RM, Forastiere, F, Haupt, R, Lagorio, S, Risica, S, and Polichetti, A

Subjects
Settore MED/42 - Igiene Generale E Applicata, childhood leukemia, childhood neoplasm
Abstract

Background Aetiology of childhood leukaemia and childhood neoplasm is poorly understood. Information on the prevalence of risk factors in the childhood population is limited. SETIL is a population based case/control study on childhood leukaemia, conducted with two companion studies on non-Hodgkin Lymphoma (NHL) and neuroblastoma. The study relies on questionnaire interviews and 50 Hz magnetic field (ELF-MF) indoor measurements. This paper discusses the SETIL study design and includes descriptive information. Methods The study was carried out in 14 Italian regions (78.3% of Italian population aged 0?10). It included leukaemia, NHL and neuroblastoma cases incident in 0?10 year olds in 1998-2001,registered by the Italian Association of Paediatric Haematology and Oncology (AIEOP)(accrual over 95% of estimated incidence). Two controls for each leukaemia case were randomly sampled from the Local Health Authorities rolls, matched by gender, birthdate and residence. The same controls were used in NHL and neuroblastoma studies. Parents were interviewed at home on: physical agents (ELF-MF and ionizing radiation), chemicals (smoking, solvents, traffic, insecticides), occupation, medical and personal history of children and parents, infectious diseases, immunizations and associated factors. Occupational exposure was collected using job specific modules. ELF-MF was measured in the main rooms (spot measurement) and close to child?s bed (48 hours measurement). Results The study included: 683 leukaemia cases (87% ALL, 13% AnLL), 97 NHL, 155 neuroblastomas, and 1044 controls.ELF-MF long term measurements were obtained for 61.1% of controls and 81.6% of leukaemia cases; 8.8% of controls were exposed at over 0.1 microTesla (μT), 3.5% and 2.1% at respectively over 0.2 and 0.3 μT. 25% of controls? fathers had smoked over 10 cigarettes/day during the year of conception, varying according to education and region. Maternal smoking was less common (71.4% did not smoke in pregnancy). Maternal passive smoking during pregnancy was reported by 31.2% of controls; the child?s passive smoking for 28.6%. Occupational exposure to solvents was estimated in 18.3% of controls? fathers and 7.7% of mothers. Contact with public was more frequent among mothers (36.1%) than fathers (23.4%). Conclusions SETIL represents a data source on exposure of Italian children to a broad array of potential carcinogenic factors.

Published
2014

13. Risk of neuroblastoma, maternal characteristics and perinatal exposures: the SETIL study

Author

Parodi S, Merlo DF, Ranucci A, Miligi L, Benvenuti A, Rondelli R, Magnani C, Haupt R, Mattioli S, Salvan A, Masera G, Rizzari C, Bisanti L, Zambon P, Greco Veneto A, Cannizzaro S, Gafà L, Luzzatto LL, Michelozzi P, Kirchmayer U, Cocco P, Galassi C, Celentano E, Guarino E, Assennato G, de Nichilo G, Bocchini V, Mosciatti P, Pubblica S, Minelli L, Chiavarini M, Cuttini M, Casotto V, Torregrossa MV, Valenti RM, Forastiere F, Lagorio S, Risica S, Polichetti A, Bochicchio F, Nuccetelli C, Biddau P, Aricò M, DeSalvo GL, Locatelli F, Pession A, Varotto S, Poggi V, Massaglia P, Monetti D, Targhetta R, Bernini G, Lippi A, Nardi M, Acquaviva A, Pannelli F, Tumori R, Sampietro G, Schilirò G, Pulsoni A, Legittimo P, Barone Adesi F, Cavariani F, Belletti I, Troeschel L, Calisti R, Marche C, Silvestri S, Sommani L, Farioli A, Tozzi GA, Terracini B, Paolucci G, Andreuccetti D, Anglesio L, Bertolotti M, Bevitori P, Biancotto R, Biggeri A, Bucci S, Comba P, Crosignani P, d'Amore G, Duglio E, Erna M, Ferrante D, Gelli L, Gilardetti M, Guidotti P, Lombardi M, Loomis D, Magnoni M, Merletti F, Miceli G, Mozzo P, Poggi A, Pons O, Rasulo A, Roletti S, Rosa M, Mestre V, Ru O, Russo G, Sgorbati G, Simonato L, Sivo D, Stievano B, Tofani S, Troti F, Tumino R, Valle M, Vecchia P, Erminio G, Galleni B., PANICO, SALVATORE, Parodi, Stefano, Merlo, Domenico Franco, Ranucci, Alessandra, Miligi, Lucia, Benvenuti, Alessandra, Rondelli, Roberto, Magnani, Corrado, Haupt, Riccardo, [ .., Mattioli, Stefano, ], Parodi, S, Merlo, Df, Ranucci, A, Miligi, L, Benvenuti, A, Rondelli, R, Magnani, C, Haupt, R, Mattioli, S, Salvan, A, Masera, G, Rizzari, C, Bisanti, L, Zambon, P, Greco Veneto, A, Cannizzaro, S, Gafà, L, Luzzatto, Ll, Michelozzi, P, Kirchmayer, U, Cocco, P, Galassi, C, Celentano, E, Guarino, E, Assennato, G, de Nichilo, G, Bocchini, V, Mosciatti, P, Pubblica, S, Minelli, L, Chiavarini, M, Cuttini, M, Casotto, V, Torregrossa, Mv, Valenti, Rm, Forastiere, F, Lagorio, S, Risica, S, Polichetti, A, Bochicchio, F, Nuccetelli, C, Biddau, P, Aricò, M, Desalvo, Gl, Locatelli, F, Pession, A, Varotto, S, Poggi, V, Massaglia, P, Monetti, D, Targhetta, R, Bernini, G, Lippi, A, Nardi, M, Acquaviva, A, Pannelli, F, Tumori, R, Sampietro, G, Schilirò, G, Pulsoni, A, Legittimo, P, Barone Adesi, F, Cavariani, F, Belletti, I, Troeschel, L, Calisti, R, Marche, C, Silvestri, S, Sommani, L, Farioli, A, Tozzi, Ga, Terracini, B, Paolucci, G, Andreuccetti, D, Anglesio, L, Bertolotti, M, Bevitori, P, Biancotto, R, Biggeri, A, Bucci, S, Comba, P, Crosignani, P, D'Amore, G, Duglio, E, Erna, M, Ferrante, D, Gelli, L, Gilardetti, M, Guidotti, P, Lombardi, M, Loomis, D, Magnoni, M, Merletti, F, Miceli, G, Mozzo, P, Panico, Salvatore, Poggi, A, Pons, O, Rasulo, A, Roletti, S, Rosa, M, Mestre, V, Ru, O, Russo, G, Sgorbati, G, Simonato, L, Sivo, D, Stievano, B, Tofani, S, Troti, F, Tumino, R, Valle, M, Vecchia, P, Erminio, G, and Galleni, B.

Subjects
Cancer Research, Pediatrics, medicine.medical_specialty, Epidemiology, Socio-culturale, ELF magnetic fields, ELF magnetic field, Nervous System Malformation, Neuroblastoma, Economica, Work related exposure, parental occupation, male, Pregnancy, Risk Factors, maternal exposure, medicine, Parental occupation, Maternal characteristic, Neurofibromatosis, humans, Neurofibromatosi, neurofibromatosis, business.industry, Risk Factor, Incidence (epidemiology), case-control studies, Ambientale, Congenital malformations, nervous system malformations, Odds ratio, medicine.disease, Pregnancy Complication, Pregnancy Complications, female, Oncology, congenital malformations, maternal characteristics, neuroblastoma, incidence, Etiology, Congenital malformation, Case-Control Studie, business, Human
Abstract

Purpose: Neuroblastoma (NB) is the most common extra-cranial paediatric solid tumour. Incidence peaks in infancy, suggesting a role of in-utero and neonatal exposures but its aetiology is largely unknown. The aim of the present study is to evaluate the association between maternal characteristics and perinatal factors with the risk of NB, using data from the SETIL database. Methods: SETIL is a large Italian population-based case-control study established to evaluate several potential cancer risk factors in 0-10 year olds. Information about maternal characteristics, reproductive history, environmental and occupational exposures during pregnancy, as well as newborns' characteristics were obtained using a structured questionnaire. Extremely low frequency magnetic field (ELF-MF) home exposure was measured. The study included 1044 healthy controls and 153 NB cases, diagnosed between 1998 and 2001. Results: A twofold risk was associated to exposure in pregnancy to chemical products for domestic work and to hair dye. The risk associated with the latter was higher among 0-17 month old children (OR. =. 5.5, 95%CI: 1.0-29.3). Risk was increased for children whose mothers had suffered work related exposure in the preconception period to solvents (OR. =. 2.0 95%CI: 1.0-4.1) and in particular to aromatic hydrocarbons (OR. =. 9.2, 95%CI: 2.4-34.3). No association was observed with ELF-MF exposure. A higher risk was found among children with congenital malformations (OR. =. 4.9, 95%CI: 1.8-13.6) or neurofibromatosis (2 cases and 0 controls, p=. 0.016). Conclusions: Our study suggests maternal exposure to hair dyes and aromatic hydrocarbons plays a role and deserves further investigation. The association with congenital malformations might also be explained by over-diagnosis.External exposure, in particular during and before pregnancy might contribute to NB occurrence.

Published
2014

14. Adapted physical activity for the promotion of health and the prevention of multifactorial chronic diseases: The Erice Charter

Author

Spica, V. R., Macini, P., Galeone, D., Liguori, G., Signorelli, C., Marensi, L., Vagali, P., Guberti, E., Goletti, M., Mammina, C., Tabacchi, G., Izzotti, A., Cinquetti, S., Pellizzari, B., Beltrami, P., Alonzo, E., Gradilone, A., Leoni, E., Buono, P., Brandi, G., Di Rosa, E., Parisi, A., Capolongo, S., Fantuzzi, G., Aggazzotti, G., Grillo, C., Borella, P., Manzoli, L., Fabiani, L., Faggiano, F., Mete, R., Privitera, G., Coniglio, M. A., Frangella, C., Rossi, D., Lagorio, S., Pasquarella, M. L., Isabella, A., Tripi, F., Franceschetti, R., Commare, A. L., Galle, F., Brandimarte, M. A., Savino, G., Di Onofrio, V., Tortorella, F., Gabriele, M., Monreale, V., Abrignani, M., Ferreri, G., Cacciapuoti, A., Valeriani, F., Raffo, M., Matarese, M., Ripani, M., Altana, V., Antonioni, S., Anzalone, C., Astorino, G., Azzollini, A., Belfiore, P., Valentini, F. B., Bragazzi, N. L., Calaciura, A., Casano, D., Ciulla, A., Cono, O. E., Contrisciani, R., Cosenza, B., D'Aloisio, F., Antonino, D. F., Marchis, A. D., Francesco, D. N., Fabri, S., Famiglietti, E., Gandolfi, A., Genovese, C., Genovesi, A., Gianfredi, V., Gigante, S., Gigliotti, A., Iacona, C., Innocenzi, L., Laurita, V., Maratea, F., Meletti, L., Memmini, S., Messana, M. A., Morelli, C., Nappi, M. R., Nucci, D., Orlandi, P., Palamara, M. A. R., Patti, A., Persi, Y., Polisano, B., Roccaro, D., Ricchiuti, R., Sanclemente, L., Scanavini, S., Sirtori, M. D., Soncini, F., Stelitano, G. I., Valenzano, A. A., Veicsteinas, A., Fara, G. M., Giammanco, G., and Romano-Spica, V.

Subjects
Biomedical Research, Prevention, Adapted physical activity, Health Promotion, Motor Activity, Primary Prevention, Attività fisica adattata, Italy, Physicians, Chronic Disease, Humans, Public Health, Adapted physical activity, Attività fisica adattata, Health promotion, Prevention, Biomedical Research, Chronic Disease, Health Promotion, Humans, Italy, Motor Activity, Physicians, Primary Prevention, Specialization, Public Health, Specialization
Published
2015

15. Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy

Author

Magnani, C., Ranucci, A., Badaloni, C., Cesaroni, G., Ferrante, D., Miligi, L., Mattioli, S., Rondelli, R., Bisanti, L., Zambon, P., Cannizzaro, S., Michelozzi, P., Cocco, P., Celentano, E., Assennato, G., Merlo, D. F., Mosciatti, P., Minelli, L., Cuttini, M., Torregrossa, M. V., Lagorio, S., Haupt, R., Forastiere, F., Farioli, A., Salvan, A., Masera, G., Rizzari, C., Greco Veneto, A., Gafa, L., Luzzatto, L. L., Benvenuti, A., Kirchmayer, U., Galassi, C., Guarino, E., de Nichilo, G., Bocchini, V., Chiavarini, M., Casotto, V., Valenti, R. M., Risica, S., Polichetti, A., Bochicchio, F., Nuccetelli, C., Biddau, P., Arico, M., Desalvo, G. L., Locatelli, Franco, Pession, A., Varotto, S., Poggi, V., Massaglia, P., Monetti, D., Targhetta, R., Bernini, G., Pannelli, F., Sampietro, G., Schiliro, G., Pulsoni, A., Parodi, S., Locatelli F. (ORCID:0000-0002-7976-3654), Magnani, C., Ranucci, A., Badaloni, C., Cesaroni, G., Ferrante, D., Miligi, L., Mattioli, S., Rondelli, R., Bisanti, L., Zambon, P., Cannizzaro, S., Michelozzi, P., Cocco, P., Celentano, E., Assennato, G., Merlo, D. F., Mosciatti, P., Minelli, L., Cuttini, M., Torregrossa, M. V., Lagorio, S., Haupt, R., Forastiere, F., Farioli, A., Salvan, A., Masera, G., Rizzari, C., Greco Veneto, A., Gafa, L., Luzzatto, L. L., Benvenuti, A., Kirchmayer, U., Galassi, C., Guarino, E., de Nichilo, G., Bocchini, V., Chiavarini, M., Casotto, V., Valenti, R. M., Risica, S., Polichetti, A., Bochicchio, F., Nuccetelli, C., Biddau, P., Arico, M., Desalvo, G. L., Locatelli, Franco, Pession, A., Varotto, S., Poggi, V., Massaglia, P., Monetti, D., Targhetta, R., Bernini, G., Pannelli, F., Sampietro, G., Schiliro, G., Pulsoni, A., Parodi, S., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Background The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. Aim of the study We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic. Methods We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic–ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls. Information on traffic exposure was collected from questionnaire interviews and from the geocoding of house addresses, for all periods of life of the children. Results We observed an increase in risk for AnLL, and at a lower extent for ALL, with indicators of exposure to traffic pollutants. In particular, the risk was associated to the report of closeness of the house to traffic lights and to the passage of trucks (OR: 1.76; 95% CI 1.03–3.01 for ALL and 6.35; 95% CI 2.59–15.6 for AnLL). The association was shown also in the analyses limited to AML and in the stratified analyses and in respect to the house in different period of life. Conclusions Results from the SETIL study provide some support to the association of traffic related exposure and risk for AnLL, but at a lesser extent for ALL. Our conclusion highlights the need for leukemia type specific analyses in future studies. Results support the need of controlling exposure from traffic pollution, even if knowledge is not complete.

Published
2016

16. Carta delle volontà anticipate

Author

Borsellino, P, Fucci, F, Gallucci, M, Pocar, V, Di Mola, G, Mori, M, Lagorio, S, BORSELLINO, PATRIZIA, Lagorio, S., Borsellino, P, Fucci, F, Gallucci, M, Pocar, V, Di Mola, G, Mori, M, Lagorio, S, BORSELLINO, PATRIZIA, and Lagorio, S.

Published
2008

17. Mortality from cancer and other causes in commercial airline crews: A joint analysis of cohorts from 10 countries

Author

Hammer, G.P. Auvinen, A. De Stavola, B.L. Grajewski, B. Gundestrup, M. Haldorsen, T. Hammar, N. Lagorio, S. Linnersjö, A. Pinkerton, L. Pukkala, E. Rafnsson, V. Dos-Santos-Silva, I. Storm, H.H. Strand, T.-E. Tzonou, A. Zeeb, H. Blettner, M.

Subjects
health care facilities, manpower, and services, education, technology, industry, and agriculture
Abstract

Background: Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. Methods: This study analyses mortality in a pooled cohort of 93 771 crew members from 10 countries. The cohort was followed for a mean of 21.7 years (2.0 million person-years), during which 5508 deaths occurred. Results: The overall mortality was strongly reduced in male cockpit (SMR 0.56) and female cabin crews (SMR 0.73). The mortality from radiation-related cancers was also reduced in male cockpit crew (SMR 0.73), but not in female or male cabin crews (SMR 1.01 and 1.00, respectively). The mortality from female breast cancer (SMR 1.06), leukaemia and brain cancer was similar to that of the general population. The mortality from malignant melanoma was elevated, and significantly so in male cockpit crew (SMR 1.57). The mortality from cardiovascular diseases was strongly reduced (SMR 0.46). On the other hand, the mortality from aircraft accidents was exceedingly high (SMR 33.9), as was that from AIDS in male cabin crew (SMR 14.0). Conclusions: This large study with highly complete follow-up shows a reduced overall mortality in male cockpit and female cabin crews, an increased mortality of aircraft accidents and an increased mortality in malignant skin melanoma in cockpit crew. Further analysis after longer follow-up is recommended.

Published
2014

18. Carta delle volontà anticipate

Author

BORSELLINO, PATRIZIA, Fucci, F, Gallucci, M, Pocar, V, Di Mola, G, Mori, M, Lagorio, S., Borsellino, P, Fucci, F, Gallucci, M, Pocar, V, Di Mola, G, Mori, M, and Lagorio, S

Subjects
volontà anticipate, scelte, autodeterminazione, cure, fine vita
Published
2008

19. Setil:Italian multicentric epidemiological study on risk factors for childhood leukemia, non Hodgkin lymphoma and neuroblastoma

Author

Magnani,C, TORREGROSSA, Maria Valeria, V, Assennato,G, Bisanti,L, Cannizzaro,S, Celentano,E, Cocco,L, Cuttini,M, DeSalvo,G, Forastiere,F, Haupt,R, Lagorio,S, Mattioli,S, Merlo,F, Michelozzi,P, Miligi,L, Magnani,C, Torregrossa,M,V, Assennato,G, Bisanti,L, Cannizzaro,S, Celentano,E, Cocco,L, Cuttini,M, DeSalvo,G, Forastiere,F, Haupt,R, Lagorio,S, Mattioli,S, Merlo,F, Michelozzi,P, and Miligi,L

Subjects
epidemiology, risk factors, leukemia, Settore MED/42 - Igiene Generale E Applicata
Published
2008

20. Alla fine della vita

Author

BORSELLINO, PATRIZIA, Da Col, D, Di Mola, G., Fucci, G, Gallucci, M, Lagorio, S, Mori, M, Pocar, V, Tomamichel, M., Borsellino, P, Da Col, D, Di Mola, G, Fucci, G, Gallucci, M, Lagorio, S, Mori, M, Pocar, V, and Tomamichel, M

Subjects
fine vita, casi, etica
Published
2002

21. Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study

Author

Cardis, E., Deltour, I., Vrijheid, M., Combalot, E., Moissonnier, M., Tardy, H., Armstrong, B., Giles, G., Brown, J., Siemiatycki, J., Parent, M. E., Nadon, L., Krewski, D., McBride, M. L., Johansen, C., Collatz, Christensen H., Auvinen, A., Kurttio, P., Lahkola, A., Salminen, T., Hours, M., Bernard, M., Montestruq, L., Schuez, J., Berg-Beckhoff, Gabriele, Schlehofer, B., Blettner, M., Sadetzki, S., Chetrit, A., Jarus-Hakak, A., Lagorio, S., Iavarone, I., Takebayashi, T., Yamaguchi, N., Woodward, A., Cook, A., Pearce, N., Tynes, T., Blaasaas, K. G., Klaeboe, L., Feychting, M., Loenn, S., Ahlbom, A., McKinney, P. A., Hepworth, S. J., Muir, K. R., Swerdlow, A. J., Schoemaker, M. J., Center for Research in Environmental Epidemiology (CREAL), and Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Pathology, Relation (database), Epidemiology, Mobile telephone, Meningioma, 03 medical and health sciences, Electromagnetic Fields, 0302 clinical medicine, Glioma, Internal medicine, Odds Ratio, medicine, Humans, 030212 general & internal medicine, neoplasms, mobile phones, Brain Neoplasms, business.industry, Brain tumours, Case-control study, General Medicine, Middle Aged, medicine.disease, 3. Good health, nervous system diseases, Increased risk, Case-Control Studies, 030220 oncology & carcinogenesis, Cellular Phone, Medicine, Female, radiofrequency fields, business, Cell Phone
Abstract

International audience; Background: The rapid increase in mobile telephone use has generated concern about possible health risks related to radiofrequency electromagnetic fields from this technology. Methods: An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol. Results: A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma (OR 0.81, 95% confidence interval (CI): 0.70, 0.94) and meningioma (OR 0.79; 95% CI 0.68, 0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed 10 or more years after first phone use (glioma: OR 0.98, 95% CI 0.76, 1.26; meningioma: OR 0.83, 95% CI 0.61, 1.14). Odds ratios were below 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the tenth decile of recalled cumulative call time, 1640 hours or longer, the odds ratio was 1.40 (95% CI 1.03, 1.89) for glioma, and 1.15 (95% CI 0.81, 1.62) for meningioma; but there are implausible values of reported use in this group. Odds ratios for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the confidence intervals around the lobe-specific estimates were wide. Odds ratios for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side. Conclusions: Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation.

Published
2010

28. Location of Gliomas in Relation to Mobile Telephone Use: A Case-Case and Case-Specular Analysis

Author

Larjavaara, S., primary, Schuz, J., additional, Swerdlow, A., additional, Feychting, M., additional, Johansen, C., additional, Lagorio, S., additional, Tynes, T., additional, Klaeboe, L., additional, Tonjer, S. R., additional, Blettner, M., additional, Berg-Beckhoff, G., additional, Schlehofer, B., additional, Schoemaker, M., additional, Britton, J., additional, Mantyla, R., additional, Lonn, S., additional, Ahlbom, A., additional, Flodmark, O., additional, Lilja, A., additional, Martini, S., additional, Rastelli, E., additional, Vidiri, A., additional, Kahara, V., additional, Raitanen, J., additional, Heinavaara, S., additional, and Auvinen, A., additional

Published
2011
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29. [Exposure to benzene of service station employees and composition of benzene]

Author

Lagorio S, Fuselli S, Ivano Iavarone, Vanacore N, and Carere A

Subjects
Occupational Exposure, Humans, Regression Analysis, Benzene, Air Pollutants, Occupational, Seasons, Occupations, Automobiles, Gasoline
Abstract

The International Agency for Research on Cancer (IARC) classifies gasoline vapours and exhaust fumes from gasoline fueled automobiles as potential human carcinogens. Data on the chemical composition of gasoline marketed in Italy and especially on the concentration of benzene, are rather poor. Within the framework of an investigation aimed at assessing the mean annual level of exposure to aromatic hydrocarbons among gasoline pump attendants, made on a sample of attendants in Rome between December 1991 and November 1992, samples of gasoline were also collected so as to determine the benzene content of the gasoline over the investigation period, assess the variability of benzene concentration in the various gasolines and according to the season of the year, and take account of gasoline composition in analysing the factors determining individual exposure levels of pump attendants. Benzene exposure was measured via gas chromatography of air samples obtained with personal pumps in the breathing zone. The mean benzene exposure level (8 h TWA) of the 27 subjects under study was 1.73 mg/m3 (SD = 5.53). The benzene concentration in the samples of gasoline, which were collected on the same day as personal exposure monitoring was performed, was measured by means of high resolution gas chromatography (hr-GC). Mean benzene levels of 25.03 g/l (SD = 3.47), equivalent to 2.86% by volume, were measured in 24 samples of alkylated gasoline, and mean levels of 23.18 g/l (SD = 3.93), equivalent to 2.65% v/v, were measured in 10 samples of lead-free gasoline. Statistically significant associations were found between individual exposure to benzene and the quantity of gasoline pumped (r = 0.69) and the quantity of benzene present in the gasoline sold on the day monitoring was performed (r = 0.70). Using regression analysis, the estimated increase in the level of personal benzene exposure was 0.01 mg/m3 for every increase of 100 g in the benzene content of the total amount of gasoline sold. This estimation could be used to quantify the expected reduction in benzene exposure levels in service station attendants following a reduction in the benzene content of gasoline.

Published
1994

31. Alla fine della vita

Author

Borsellino, P, Da Col, D, Di Mola, G, Fucci, G, Gallucci, M, Lagorio, S, Mori, M, Pocar, V, Tomamichel, M, BORSELLINO, PATRIZIA, Di Mola, G., Tomamichel, M., Borsellino, P, Da Col, D, Di Mola, G, Fucci, G, Gallucci, M, Lagorio, S, Mori, M, Pocar, V, Tomamichel, M, BORSELLINO, PATRIZIA, Di Mola, G., and Tomamichel, M.

Published
2002

37. Oxidation processes and their effects on the magnetic remanence of Early Cretaceous subaerial basalts from Sierra Chica de Córdoba, Argentina

Author

Geuna, S. E., Lagorio, S. L., and Vizán, H.

Abstract

We carried out magnetic analyses on a sequence of Cretaceous alkaline–transitional subaerial basalts of Córdoba Province, Argentina, which have high-Ti magnetite as the main opaque phase. Three different groups are identified based on the degree of high-temperature oxidation during the lava extrusion, combined with superimposed maghemitization and hematization. In the first group, titanomagnetites are optically homogeneous or exhibit coarse intergrowths with ilmenite. The magnetic susceptibility and its variation with temperature and magnetic field point to Ti-poorer compositions than those indicated by electron microprobe, which is interpreted as due to low-temperature oxidation with subsolvus microexsolution. The second group of basalts suffered moderate high-temperature oxidation, with crowded exsolved ilmenite laths within a Ti-poor magnetitesshost, followed by maghemitization and hematite replacement. The third group shows a strongly advanced degree of low-temperature alteration, with the virtual disappearance of magnetite. Based on magnetic properties and field tests applied to the magnetic remanence, we interpret that maghemitization and hematization must have been responsible for the acquisition of a stable magnetic remanence, in the presence of hydrothermal fluids coeval with volcanism. The most advanced degree of alteration, typical of highly porous amygdaloidal lava flows and volcanic breccias, occurred later, probably due to weathering.

Published
2015
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41. Update of evidence on the association of childhood leukemia and 50/60 Hz magnetic field exposure.

Author

LOOMIS, D A N A, LAGORIO, S U S A N N A, SALVAN, A L B E R T O, and COMBA, P I E T R O

Subjects
*LEUKEMIA, *CHILDREN, *MAGNETIC fields
Abstract

Discusses that the United States National Research Council (NRC) conducted a review and meta-analysis of epidemiological studies of childhood leukemia and residential exposure to magnetic filds. Three indicators of exposures that were used to associate it with childhood leukemia; Reasons for selecting these indicators by NCR; Summary of the meta-analysis given by NCR.

Published
1999
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